| PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
physical |
9 |
2 |
9 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
7 |
3 |
7 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS |
| PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
physical |
5 |
2 |
5 |
Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| PRE6 |
YOL038W |
Alpha 4 subunit of the 20S proteasome |
genetic |
5 |
2 |
3 |
Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
5 |
2 |
3 |
Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SCL1 |
YGL011C |
Alpha 1 subunit of the 20S proteasome |
genetic |
4 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic |
| PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
4 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic |
| PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| PRE6 |
YOL038W |
Alpha 4 subunit of the 20S proteasome |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| PRE8 |
YML092C |
Alpha 2 subunit of the 20S proteasome |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
physical |
3 |
1 |
3 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| PUP2 |
YGR253C |
Alpha 5 subunit of the 20S proteasome |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RNT1 |
YMR239C |
Nuclear dsRNA-specific ribonuclease (RNase III) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RPL11B |
YGR085C |
Ribosomal 60S subunit protein L11B |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| IRC25 |
YLR021W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
3 |
2 |
1 |
Positive Genetic, Negative Genetic, Negative Genetic |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
3 |
2 |
1 |
Positive Genetic, Negative Genetic, Negative Genetic |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
| PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| PRE3 |
YJL001W |
Beta 1 subunit of the 20S proteasome |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| RPN10 |
YHR200W |
Proteasome polyubiquitin receptor |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SCL1 |
YGL011C |
Alpha 1 subunit of the 20S proteasome |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| SEC61 |
YLR378C |
Conserved ER protein translocation channel |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SRC1 |
YML034W |
Inner nuclear membrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SSP2 |
YOR242C |
Sporulation specific protein that localizes to the spore wall |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| PGM1 |
YKL127W |
Phosphoglucomutase, minor isoform |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MMR1 |
YLR190W |
Phosphorylated protein of the mitochondrial outer membrane |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PRE5 |
YMR314W |
Alpha 6 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| PRE3 |
YJL001W |
Beta 1 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| PRE8 |
YML092C |
Alpha 2 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PUP1 |
YOR157C |
Beta 2 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPT2 |
YDL007W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPT3 |
YDR394W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| RPN8 |
YOR261C |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PUP3 |
YER094C |
Beta 3 subunit of the 20S proteasome |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RPL9B |
YNL067W |
Ribosomal 60S subunit protein L9B |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ARO1 |
YDR127W |
Pentafunctional arom protein |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| MGA2 |
YIR033W |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ISU1 |
YPL135W |
Conserved protein of the mitochondrial matrix |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PAM16 |
YJL104W |
Subunit of the import motor (PAM complex) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| GPI2 |
YPL076W |
Protein involved in the synthesis of GlcNAc-PI |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| ABF1 |
YKL112W |
DNA binding protein with possible chromatin-reorganizing activity |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| GWT1 |
YJL091C |
Protein involved in the inositol acylation of GlcN-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| AXL2 |
YIL140W |
Integral plasma membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRR2 |
YER172C |
RNA-dependent ATPase RNA helicase (DEIH box) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE29 |
YER038C |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARL1 |
YBR164C |
Soluble GTPase with a role in regulation of membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MES1 |
YGR264C |
Methionyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP56 |
YLR197W |
Essential evolutionarily-conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK21 |
YDR060W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DED1 |
YOR204W |
ATP-dependent DEAD-box RNA helicase with strand-annealing activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAB1 |
YER165W |
Poly(A) binding protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP9 |
YMR033W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MED7 |
YOL135C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
physical |
1 |
1 |
1 |
Two-hybrid |
| SSK22 |
YCR073C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
physical |
1 |
1 |
1 |
Two-hybrid |
| PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUP2 |
YGR253C |
Alpha 5 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUP1 |
YOR157C |
Beta 2 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TAF14 |
YPL129W |
Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes |
physical |
1 |
1 |
1 |
PCA |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| TOM1 |
YDR457W |
E3 ubiquitin ligase of the hect-domain class |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TTI2 |
YJR136C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YCG1 |
YDR325W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SRP102 |
YKL154W |
Signal recognition particle (SRP) receptor beta subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YNL140C |
YNL140C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STP22 |
YCL008C |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SET3 |
YKR029C |
Defining member of the SET3 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIN4 |
YNL236W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC20 |
YDR498C |
Membrane glycoprotein v-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC53 |
YFL045C |
Phosphomannomutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP18 |
YGR006W |
Splicing factor and component of snRNP U5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRN3 |
YKL125W |
Protein required for transcription of rDNA by RNA polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIM50 |
YPL063W |
Essential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC62 |
YPL094C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIB5 |
YBR256C |
Riboflavin synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPP41 |
YDR464W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPB4 |
YFL002C |
Putative ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URB2 |
YJR041C |
Protein required for normal metabolism of the rRNA primary transcript |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URA6 |
YKL024C |
Uridylate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPF2 |
YKR081C |
Essential protein involved in rRNA maturation and ribosomal assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL15A |
YLR029C |
Ribosomal 60S subunit protein L15A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEN2 |
YLR105C |
Subunit of the tRNA splicing endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC8 |
YPR055W |
Essential 121 kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSH1 |
YBR283C |
Subunit of the Ssh1 translocon complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCR090C |
YCR090C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMD1 |
YDL001W |
Cytoplasmic protein required for sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP1 |
YDL122W |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP1B |
YDL130W |
Ribosomal protein P1 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD30 |
YDR419W |
DNA polymerase eta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL27B |
YDR471W |
Ribosomal 60S subunit protein L27B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YER084W |
YER084W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YRB30 |
YGL164C |
RanGTP-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF6 |
YHL025W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL8A |
YHL033C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKL075C |
YKL075C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR053C |
YLR053C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAM1 |
YLR180W |
S-adenosylmethionine synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL37A |
YLR185W |
Ribosomal 60S subunit protein L37A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL31B |
YLR406C |
Ribosomal 60S subunit protein L31B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBX4 |
YMR067C |
UBX domain-containing protein that interacts with Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS16A |
YMR143W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL36A |
YMR194W |
Ribosomal 60S subunit protein L36A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO1 |
YNL012W |
Meiosis-specific prospore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS28A |
YOR167C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRO7 |
YPR032W |
Effector of Rab GTPase Sec4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE3 |
YPR069C |
Spermidine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR221W-A |
YBR221W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDL124W |
YDL124W |
NADPH-dependent alpha-keto amide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC8 |
YEL013W |
Vacuole-specific Myo2p receptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL34A |
YER056C-A |
Ribosomal 60S subunit protein L34A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL242C |
YGL242C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS23A |
YGR118W |
Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YIL089W |
YIL089W |
Protein of unknown function found in the ER and vacuole lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS21A |
YKR057W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLL032C |
YLL032C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRT15 |
YLR162W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS28B |
YLR264W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS1A |
YLR441C |
Ribosomal protein of the small (40S) subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRM9 |
YML014W |
tRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UNG1 |
YML021C |
Uracil-DNA glycosylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPK2 |
YMR104C |
AGC-type S/T protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPG5 |
YMR191W |
Protein required for proteasome assembly during quiescence |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRF5 |
YNL299W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR011W-A |
YOR011W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL33B |
YOR234C |
Ribosomal 60S subunit protein L33B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUT4 |
YOR348C |
Proline permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPL060C-A |
YPL060C-A |
TyA Gag protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL13A |
YDL082W |
Ribosomal 60S subunit protein L13A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF11 |
YML015C |
TFIID subunit (40 kDa) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP4 |
YPR178W |
Splicing factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YML108W |
YML108W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR085C-A |
YBR085C-A |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALA1 |
YOR335C |
Cytoplasmic and mitochondrial alanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP1 |
YOL149W |
Subunit of the Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FPR1 |
YNL135C |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCN1 |
YGL195W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCN3 |
YKR026C |
Alpha subunit of translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAP2 |
YGL237C |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ECM29 |
YHL030W |
Scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| KGD2 |
YDR148C |
Dihydrolipoyl transsuccinylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LST8 |
YNL006W |
Protein required for the transport of Gap1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MAK3 |
YPR051W |
Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAL12 |
YGR292W |
Maltase (alpha-D-glucosidase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH2 |
YOL090W |
Protein that binds to DNA mismatches |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NHP6B |
YBR089C-A |
High-mobility group (HMG) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG18 |
YFR021W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAS2 |
YPL231W |
Alpha subunit of fatty acid synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH22 |
YDL188C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| BLM10 |
YFL007W |
Proteasome activator |
physical |
1 |
1 |
1 |
Protein-peptide |
| PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HTA1 |
YDR225W |
Histone H2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAB3 |
YPL190C |
RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCN20 |
YFR009W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MKT1 |
YNL085W |
Protein similar to nucleases that forms a complex with Pbp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FYV8 |
YGR196C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAS6 |
YGR232W |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DAL3 |
YIR032C |
Ureidoglycolate lyase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BET5 |
YML077W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GET3 |
YDL100C |
Guanine nucleotide exchange factor for Gpa1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAR11 |
YNL127W |
Protein involved in recovery from cell cycle arrest |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMS2 |
YGL087C |
Ubiquitin-conjugating enzyme variant |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC53 |
YDL132W |
Cullin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GSF2 |
YML048W |
Endoplasmic reticulum (ER) localized integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD13 |
YGL174W |
Subunit of the RES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| COF1 |
YLL050C |
Cofilin, involved in pH-dependent actin filament depolarization |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FAR10 |
YLR238W |
Protein involved in recovery from arrest in response to pheromone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA1 |
YNL099C |
Putative protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBA1 |
YLR199C |
Protein involved in 20S proteasome assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HOM3 |
YER052C |
Aspartate kinase (L-aspartate 4-P-transferase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LSM8 |
YJR022W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAL1 |
YDR021W |
Nucleolar protein required for maturation of 18S rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUB1 |
YCR076C |
Proteasome-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| FUB1 |
YCR076C |
Proteasome-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEH1 |
YKR007W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DUT1 |
YBR252W |
Deoxyuridine triphosphate diphosphatase (dUTPase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FCF1 |
YDR339C |
PINc domain endonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KKQ8 |
YKL168C |
Putative serine/threonine protein kinase with unknown cellular role |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ATP5 |
YDR298C |
Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NAS2 |
YIL007C |
Evolutionarily conserved 19S regulatory particle assembly-chaperone |
physical |
1 |
1 |
1 |
Two-hybrid |
| DID4 |
YKL002W |
Class E Vps protein of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC43 |
YGL155W |
Beta subunit of geranylgeranyltransferase type I |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CIN4 |
YMR138W |
GTP-binding protein involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIT2 |
YCR005C |
Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FAR3 |
YMR052W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMN1 |
YDR236C |
Riboflavin kinase, produces riboflavin monophosphate (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP157 |
YER105C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Two-hybrid |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPG1 |
YNR032W |
Serine protein phosphatase involved in formation of FAR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG4 |
YPR105C |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAM18 |
YLR008C |
Subunit of the import motor (PAM complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FIG4 |
YNL325C |
Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IQG1 |
YPL242C |
Actin filament binding protein that enhances actin ring formation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC19 |
YAL038W |
Pyruvate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET28 |
YIR017C |
bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KEX2 |
YNL238W |
Kexin, a subtilisin-like protease (proprotein convertase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAC1 |
YFL031W |
Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ERG5 |
YMR015C |
C-22 sterol desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM44 |
YPL158C |
Regulator of Cdc42p and Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IDS2 |
YJL146W |
Protein involved in modulation of Ime2p activity during meiosis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBN1 |
YCL052C |
Component of glycosylphosphatidylinositol-mannosyltransferase I |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BTS1 |
YPL069C |
Geranylgeranyl diphosphate synthase (GGPPS) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NDJ1 |
YOL104C |
Protein that regulates meiotic SPB cohesion and telomere clustering |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRC7 |
YFR055W |
Cysteine desulphydrase, enables growth on cysteine as nitrogen source |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFS1 |
YCL017C |
Cysteine desulfurase involved in iron-sulfur cluster biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMT5 |
YDL093W |
Protein O-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM22 |
YJL046W |
Lipoate-protein ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUE3 |
YGL110C |
Subunit of ribosome-associated quality control trigger complex (RQT) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACB1 |
YGR037C |
Acyl-CoA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP12 |
YJL180C |
Assembly factor for F1 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE28 |
YDR532C |
Subunit of a kinetochore-microtubule binding complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COA3 |
YJL062W-A |
Mitochondrial protein required for cytochrome c oxidase assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PHB2 |
YGR231C |
Subunit of the prohibitin complex (Phb1p-Phb2p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| APJ1 |
YNL077W |
Hsp40 chaperone with a role in SUMO-mediated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CMK2 |
YOL016C |
Calmodulin-dependent protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NMT1 |
YLR195C |
N-myristoyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALO1 |
YML086C |
D-Arabinono-1,4-lactone oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASP1 |
YDR321W |
Cytosolic L-asparaginase, involved in asparagine catabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PNP1 |
YLR209C |
Purine nucleoside phosphorylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NEO1 |
YIL048W |
Phospholipid translocase (flippase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ALG7 |
YBR243C |
UDP-N-acetyl-glucosamine-1-P transferase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BIG1 |
YHR101C |
Integral membrane protein of the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PET18 |
YCR020C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM14 |
YGL160W |
NADPH oxidase localized to the perinuclear ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTS1 |
YPR033C |
Cytoplasmic and mitochondrial histidine tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBP4 |
YGR174C |
Mitochondrial protein required for assembly of cytochrome bc1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI10 |
YGL142C |
Integral membrane protein involved in GPI anchor synthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LCL2 |
YLR104W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DIT2 |
YDR402C |
N-formyltyrosine oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSS2 |
YDL107W |
Peripherally bound inner membrane protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LDO16 |
YMR148W |
Protein of unknown function with possible role in spore wall assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENV9 |
YOR246C |
Conserved oxidoreductase involved in lipid droplet morphology |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAR1 |
YNL240C |
Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ICT1 |
YLR099C |
Lysophosphatidic acid acyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DBR1 |
YKL149C |
RNA lariat debranching enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEM4 |
YOR278W |
Uroporphyrinogen III synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
