| ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
physical |
17 |
3 |
15 |
Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
| MTR2 |
YKL186C |
mRNA transport regulator |
physical |
12 |
4 |
10 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
10 |
5 |
6 |
Affinity Capture-Western, Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
physical |
9 |
3 |
8 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western |
| NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
9 |
5 |
7 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Co-purification, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
physical |
9 |
2 |
7 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
physical |
9 |
5 |
4 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, FRET, Affinity Capture-MS |
| LSG1 |
YGL099W |
Putative GTPase involved in 60S ribosomal subunit biogenesis |
physical |
8 |
2 |
7 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| SLX9 |
YGR081C |
Protein required for pre-rRNA processing |
genetic |
8 |
4 |
5 |
Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue, Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic |
| NMD3 |
YHR170W |
Protein involved in nuclear export of the large ribosomal subunit |
physical |
7 |
2 |
6 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
| NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
6 |
2 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
6 |
2 |
6 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| NPL3 |
YDR432W |
RNA-binding protein |
physical |
6 |
3 |
4 |
Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
genetic |
5 |
3 |
5 |
Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement |
| NSP1 |
YJL041W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
5 |
4 |
4 |
Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, FRET, Affinity Capture-MS |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
5 |
3 |
4 |
Negative Genetic, Dosage Rescue, Negative Genetic, Synthetic Rescue, Synthetic Rescue |
| NUP1 |
YOR098C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
5 |
3 |
4 |
Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
5 |
2 |
4 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
genetic |
5 |
4 |
3 |
Dosage Rescue, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
physical |
5 |
3 |
3 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
4 |
2 |
4 |
Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
physical |
4 |
2 |
4 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
genetic |
4 |
4 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Dosage Rescue, Negative Genetic |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
physical |
4 |
3 |
3 |
Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| NMD3 |
YHR170W |
Protein involved in nuclear export of the large ribosomal subunit |
genetic |
4 |
3 |
3 |
Dosage Rescue, Synthetic Lethality, Dosage Rescue, Negative Genetic |
| BUD20 |
YLR074C |
C2H2-type zinc finger protein required for ribosome assembly |
physical |
4 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS |
| ECM1 |
YAL059W |
Pre-ribosomal factor involved in 60S ribosomal protein subunit export |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| MTR2 |
YKL186C |
mRNA transport regulator |
genetic |
4 |
2 |
3 |
Dosage Rescue, Dosage Rescue, Dosage Rescue, Negative Genetic |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| POM34 |
YLR018C |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| POM152 |
YMR129W |
Glycoprotein subunit of transmembrane ring of nuclear pore complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
| IOC4 |
YMR044W |
Member of a complex (Isw1b) with Isw1p and Ioc2p |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Synthetic Rescue |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality |
| NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
| SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
| SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| RPL25 |
YOL127W |
Ribosomal 60S subunit protein L25 |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
genetic |
3 |
2 |
3 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression |
| PAB1 |
YER165W |
Poly(A) binding protein |
physical |
3 |
3 |
2 |
Reconstituted Complex, Co-purification, Affinity Capture-MS |
| YVH1 |
YIR026C |
Dual specificity protein phosphatase |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| GBP2 |
YCL011C |
Poly(A+) RNA-binding protein |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
physical |
3 |
1 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| DBP2 |
YNL112W |
ATP-dependent RNA helicase of the DEAD-box protein family |
genetic |
3 |
3 |
1 |
Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect |
| HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| YRA2 |
YKL214C |
Member of the REF (RNA and export factor binding proteins) family |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS |
| NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| UBI4 |
YLL039C |
Ubiquitin |
physical |
2 |
2 |
2 |
Reconstituted Complex, FRET |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-MS |
| SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
| NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-MS |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
| MFT1 |
YML062C |
Subunit of the THO complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
| SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
2 |
2 |
2 |
Dosage Growth Defect, Negative Genetic |
| RNA15 |
YGL044C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| RPT2 |
YDL007W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Rescue |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Growth Defect |
| ALB1 |
YJL122W |
Shuttling pre-60S factor |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| KAP95 |
YLR347C |
Karyopherin beta |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| BUD20 |
YLR074C |
C2H2-type zinc finger protein required for ribosome assembly |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| KAP114 |
YGL241W |
Karyopherin, responsible for nuclear import of specific proteins |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ASM4 |
YDL088C |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| YHR127W |
YHR127W |
Protein of unknown function |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP192 |
YJL039C |
Essential subunit of inner ring of nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP157 |
YER105C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NIC96 |
YFR002W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP82 |
YJL061W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| POM34 |
YLR018C |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
| NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POT1 |
YIL160C |
3-ketoacyl-CoA thiolase with broad chain length specificity |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SUB1 |
YMR039C |
Transcriptional regulator |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SAM37 |
YMR060C |
Component of the Sorting and Assembly Machinery (SAM) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ABZ2 |
YMR289W |
Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ISR1 |
YPR106W |
Predicted protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HPM1 |
YIL110W |
AdoMet-dependent methyltransferase |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Affinity Capture-RNA |
| CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| SWD2 |
YKL018W |
Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
regulation |
1 |
1 |
1 |
quantitative western immunoblotting evidence |
| UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
regulation |
1 |
1 |
1 |
quantitative western immunoblotting evidence |
| GUS1 |
YGL245W |
Glutamyl-tRNA synthetase (GluRS) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAK21 |
YDR060W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DED1 |
YOR204W |
ATP-dependent DEAD-box RNA helicase with strand-annealing activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CSL4 |
YNL232W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCP1 |
YDR361C |
Essential nuclear chaperone for ribosomal protein Rpl23p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARC15 |
YIL062C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARP3 |
YJR065C |
Essential component of the Arp2/3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP11 |
YNL315C |
Molecular chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CEG1 |
YGL130W |
Guanylyltransferase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP1 |
YOL149W |
Subunit of the Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM1 |
YAL059W |
Pre-ribosomal factor involved in 60S ribosomal protein subunit export |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ENP1 |
YBR247C |
Protein associated with U3 and U14 snoRNAs |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| DPB4 |
YDR121W |
Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| IOC3 |
YFR013W |
Subunit of the Isw1a complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| ISW2 |
YOR304W |
ATP-dependent DNA translocase involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRS1 |
YDR037W |
Lysyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LSM2 |
YBL026W |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED11 |
YMR112C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DBP2 |
YNL112W |
ATP-dependent RNA helicase of the DEAD-box protein family |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| CDC25 |
YLR310C |
Membrane bound guanine nucleotide exchange factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAM1 |
YPL048W |
One of two isoforms of the gamma subunit of eEF1B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LTV1 |
YKL143W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAR2 |
YLR438W |
L-ornithine transaminase (OTAse) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| GSP1 |
YLR293C |
Ran GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHO1 |
YPL127C |
Histone H1, linker histone with roles in meiosis and sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDH2 |
YOL126C |
Cytoplasmic malate dehydrogenase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HAP3 |
YBL021C |
Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAL1 |
YDR021W |
Nucleolar protein required for maturation of 18S rRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAS2 |
YHR024C |
Alpha subunit of the mitochondrial processing protease (MPP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FUB1 |
YCR076C |
Proteasome-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTR1 |
YPR124W |
High-affinity copper transporter of plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LOS1 |
YKL205W |
Nuclear pore protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP7 |
YKL016C |
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FMN1 |
YDR236C |
Riboflavin kinase, produces riboflavin monophosphate (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM4 |
YBR194W |
Protein proposed to be associated with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM1 |
YMR043W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTK2 |
YJL006C |
Beta subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| IOC2 |
YLR095C |
Subunit of the Isw1b complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSP1 |
YJL041W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIP6 |
YHR015W |
Putative RNA-binding protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRO3 |
YER023W |
Delta 1-pyrroline-5-carboxylate reductase |
physical |
1 |
1 |
1 |
Two-hybrid |
| MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP82 |
YJL061W |
Linker nucleoporin component of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRT4 |
YKL009W |
Protein involved in mRNA turnover and ribosome assembly |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SKM1 |
YOL113W |
Member of the PAK family of serine/threonine protein kinases |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PMA1 |
YGL008C |
Plasma membrane P2-type H+-ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SDA1 |
YGR245C |
Protein required for actin organization and passage through Start |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RIO2 |
YNL207W |
Essential serine kinase involved in the processing of 20S pre-rRNA |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RIO2 |
YNL207W |
Essential serine kinase involved in the processing of 20S pre-rRNA |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL24A |
YGL031C |
Ribosomal 60S subunit protein L24A |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RPL16A |
YIL133C |
Ribosomal 60S subunit protein L16A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS3 |
YNL178W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RPL35A |
YDL191W |
Ribosomal 60S subunit protein L35A |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| NOC4 |
YPR144C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| NOG1 |
YPL093W |
Putative GTPase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SEC61 |
YLR378C |
Conserved ER protein translocation channel |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS0A |
YGR214W |
Ribosomal 40S subunit protein S0A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS1A |
YLR441C |
Ribosomal protein of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS7A |
YOR096W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS9A |
YPL081W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS10A |
YOR293W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS12 |
YOR369C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS13 |
YDR064W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS15 |
YOL040C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS17A |
YML024W |
Ribosomal protein 51 (rp51) of the small (40s) subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS18A |
YDR450W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS19A |
YOL121C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS20 |
YHL015W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS22A |
YJL190C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL26A |
YLR344W |
Ribosomal 60S subunit protein L26A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPS14A |
YCR031C |
Protein component of the small (40S) ribosomal subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| POM152 |
YMR129W |
Glycoprotein subunit of transmembrane ring of nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NDC1 |
YML031W |
Subunit of the transmembrane ring of the nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| THO2 |
YNL139C |
Subunit of the THO complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| THO2 |
YNL139C |
Subunit of the THO complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| THP2 |
YHR167W |
Subunit of the THO and TREX complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MFT1 |
YML062C |
Subunit of the THO complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RIF1 |
YBR275C |
Protein involved in control of DNA replication |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TMA16 |
YOR252W |
Protein of unknown function that associates with ribosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MTF1 |
YMR228W |
Mitochondrial RNA polymerase specificity factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ZDS1 |
YMR273C |
Protein with a role in regulating Swe1p-dependent polarized growth |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSK1 |
YNL073W |
Mitochondrial lysine-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIF35 |
YDR429C |
eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRM9 |
YML014W |
tRNA methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUS1 |
YPL212C |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNY1 |
YPL123C |
Vacuolar RNase of the T(2) family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SAN1 |
YDR143C |
Ubiquitin-protein ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PAN2 |
YGL094C |
Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PAN3 |
YKL025C |
Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SPT6 |
YGR116W |
Nucleosome remodeling protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MFM1 |
YPL060W |
Mitochondrial inner membrane magnesium transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD7 |
YJR052W |
Nucleotide excision repair (NER) protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NAM7 |
YMR080C |
ATP-dependent RNA helicase of the SFI superfamily |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YRB2 |
YIL063C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC65 |
YML105C |
Subunit of the signal recognition particle (SRP) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| POP3 |
YNL282W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PDC2 |
YDR081C |
Transcription factor for thiamine-regulated genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPB7 |
YDR404C |
RNA polymerase II subunit B16 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ZPR1 |
YGR211W |
Essential protein with two zinc fingers |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RGR1 |
YLR071C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YAR029W |
YAR029W |
Member of DUP240 gene family but contains no transmembrane domains |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YGR018C |
YGR018C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YIA6 |
YIL006W |
Mitochondrial NAD+ transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SAC1 |
YKL212W |
Phosphatidylinositol phosphate phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SND2 |
YLR065C |
Protein involved in SRP-independent targeting of substrates to the ER |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SIW14 |
YNL032W |
Inositol phosphatase involved in inositol pyrophosphate metabolism |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MKT1 |
YNL085W |
Protein similar to nucleases that forms a complex with Pbp1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YGK3 |
YOL128C |
Protein kinase related to mammalian GSK-3 glycogen synthase kinases |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SEC17 |
YBL050W |
Alpha-SNAP cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC18 |
YBR080C |
AAA ATPase and SNARE disassembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFS1 |
YCL017C |
Cysteine desulfurase involved in iron-sulfur cluster biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDI1 |
YCL043C |
Protein disulfide isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP42 |
YDL111C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP45 |
YDR280W |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTR3 |
YGR158C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPT4 |
YOR259C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA190 |
YOR341W |
RNA polymerase I largest subunit A190 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE7 |
YBL041W |
Beta 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB5 |
YBR154C |
RNA polymerase subunit ABC27 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP7 |
YBR167C |
Subunit of RNase MRP, nuclear RNase P and telomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QRI1 |
YDL103C |
UDP-N-acetylglucosamine pyrophosphorylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPI1 |
YDR050C |
Triose phosphate isomerase, abundant glycolytic enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RHO3 |
YIL118W |
Non-essential small GTPase of the Rho/Rac family of Ras-like proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE3 |
YJL001W |
Beta 1 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHS1 |
YJL097W |
Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP21 |
YJL203W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUI2 |
YJR007W |
Alpha subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC4 |
YKR008W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NBP1 |
YLR457C |
Spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF7 |
YMR227C |
TFIID subunit (67 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAT1 |
YOR048C |
Nuclear 5' to 3' single-stranded RNA exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFC8 |
YPL007C |
Subunit of RNA polymerase III transcription initiation factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YSA1 |
YBR111C |
Nudix hydrolase family member with ADP-ribose pyrophosphatase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR219C |
YBR219C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL036W |
YGL036W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR096W |
YJR096W |
Xylose and arabinose reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YJR154W |
YJR154W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RMA1 |
YKL132C |
Putative dihydrofolate synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDH2 |
YLL041C |
Iron-sulfur protein subunit of succinate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPZ1 |
YML016C |
Serine/threonine protein phosphatase Z, isoform of Ppz2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCH1 |
YMR034C |
Negative regulator of cytosolic calcium homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA2 |
YNL056W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNL140C |
YNL140C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDH5 |
YOL071W |
Protein required for flavinylation of Sdh1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR238C |
YBR238C |
Mitochondrial membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSS2 |
YDL107W |
Peripherally bound inner membrane protein of the mitochondrial matrix |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEP7 |
YDR323C |
Adaptor protein involved in vesicle-mediated vacuolar protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NHX1 |
YDR456W |
Na+/H+ and K+/H+ exchanger |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPF1 |
YEL031W |
P-type ATPase, ion transporter of the ER membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS45 |
YGL095C |
Protein of the Sec1p/Munc-18 family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL25 |
YGR076C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PHO86 |
YJL117W |
Endoplasmic reticulum (ER) resident protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIS11 |
YLR136C |
mRNA-binding protein expressed during iron starvation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLM2 |
YNL047C |
Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MON2 |
YNL297C |
Protein with a role in endocytosis and vacuole integrity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS27 |
YNR006W |
Endosomal protein that forms a complex with Hse1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP120 |
YPL125W |
Karyopherin responsible for the nuclear import of Rpf1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EPO1 |
YMR124W |
Protein involved in septin-ER tethering |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG1 |
YBR110W |
Mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCH2 |
YKR027W |
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERG7 |
YHR072W |
Lanosterol synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EHT1 |
YBR177C |
Octanoyl-CoA:ethanol acyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUD23 |
YCR047C |
Ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COQ10 |
YOL008W |
Coenzyme Q (ubiquinone) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAB4 |
YGR277C |
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEF1 |
YLR069C |
Mitochondrial elongation factor involved in translational elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ARV1 |
YLR242C |
Cortical ER protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI12 |
YMR281W |
ER membrane protein involved in the second step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP1 |
YMR298W |
Ceramide synthase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COX7 |
YMR256C |
Subunit VII of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDS1 |
YBR029C |
Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALG2 |
YGL065C |
Mannosyltransferase in the N-linked glycosylation pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APT2 |
YDR441C |
Potential adenine phosphoribosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AGC1 |
YPR021C |
Mitochondrial amino acid transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPI1 |
YGR216C |
Membrane protein involved in the synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BCD1 |
YHR040W |
Essential protein required for the accumulation of box C/D snoRNA |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DPA10 |
YLR307C-A |
Putative mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAT3 |
YKL187C |
Protein required for fatty acid uptake |
genetic |
1 |
1 |
1 |
Negative Genetic |