Standard name Systematic name Name description Description
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase Ceramide-activated, type 2A-related serine-threonine phosphatase; functions in G1/S transition of mitotic cycle; controls lifespan, mitochondrial function, cell cycle progression by regulating HXK2 phosphorylation; regulator of COPII coat dephosphorylation; required for ER to Golgi traffic; interacts with Hrr25p kinase; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization; similar to human PP6
Visualize the interactome of SIT4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.919 NaN NaN
Mito 0.081 NaN NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 3970

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SIT4 2 1 0 3 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase physical 12 3 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 12 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
TAP42 YMR028W Essential protein involved in the TOR signaling pathway physical 9 4 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-MS
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase physical 6 2 4 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SNF1 YDR477W AMP-activated S/T protein kinase genetic 6 4 3 Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 5 2 5 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 5 3 4 Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue, Synthetic Rescue
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 5 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 4 3 4 Phenotypic Enhancement, Positive Genetic, Dosage Rescue, Dosage Rescue
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 4 2 4 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
SSD1 YDR293C Translational repressor genetic 4 3 3 Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 3 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue
MDS3 YGL197W Putative component of the TOR regulatory pathway physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 3 2 3 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NHA1 YLR138W Na+/H+ antiporter genetic 3 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue
IKI3 YLR384C Subunit of Elongator complex physical 3 3 2 Affinity Capture-Western, Co-fractionation, PCA
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 3 3 1 Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
YAK1 YJL141C Serine-threonine protein kinase genetic 2 2 2 Positive Genetic, Dosage Rescue
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
PTK2 YJR059W Serine/threonine protein kinase genetic 2 2 2 Positive Genetic, Dosage Rescue
SDS23 YGL056C Protein involved in cell separation during budding genetic 2 2 2 Dosage Rescue, Synthetic Rescue
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex regulation 2 1 2 qualitative western immunoblotting evidence, qualitative western immunoblotting evidence
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 2 1 2 Dosage Rescue, Dosage Rescue
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MRPL3 YMR024W Mitochondrial ribosomal protein of the large subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HRK1 YOR267C Protein kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 2 2 1 Synthetic Rescue, Dosage Rescue
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat physical 2 2 1 Reconstituted Complex, Biochemical Activity
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat physical 2 2 1 Reconstituted Complex, Biochemical Activity
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ATP2 YJR121W Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system regulation 1 1 1 qualitative western immunoblotting evidence
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Lethality
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Synthetic Lethality
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space physical 1 1 1 Affinity Capture-MS
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Lethality
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Dosage Rescue
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Dosage Rescue
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 1 1 1 Affinity Capture-MS
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Dosage Rescue
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase physical 1 1 1 Affinity Capture-MS
SWT21 YNL187W Protein involved in mRNA splicing physical 1 1 1 Affinity Capture-MS
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Dosage Rescue
YMR196W YMR196W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi physical 1 1 1 Biochemical Activity
TLG2 YOL018C Syntaxin-like t-SNARE physical 1 1 1 Biochemical Activity
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Co-purification
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-Western
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex physical 1 1 1 Affinity Capture-MS
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) physical 1 1 1 Affinity Capture-MS
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 1 1 1 Affinity Capture-MS
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Dosage Rescue
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Dosage Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Dosage Rescue
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Dosage Rescue
VHS2 YIL135C Regulator of septin dynamics genetic 1 1 1 Dosage Rescue
TRP1 YDR007W Phosphoribosylanthranilate isomerase genetic 1 1 1 Phenotypic Suppression
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 1 1 1 Negative Genetic
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YAP7 YOL028C Transcriptional repressor of nitric oxide oxidase genetic 1 1 1 Dosage Rescue
TPO2 YGR138C Polyamine transporter of the major facilitator superfamily genetic 1 1 1 Phenotypic Suppression
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Synthetic Rescue
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Synthetic Rescue
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Phenotypic Suppression
TPD3 YAL016W Regulatory subunit A of the heterotrimeric PP2A complex genetic 1 1 1 Synthetic Rescue
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Dosage Rescue
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Positive Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Lethality
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Dosage Rescue
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) physical 1 1 1 Affinity Capture-MS
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Enhancement
GCN2 YDR283C Protein kinase genetic 1 1 1 Positive Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Dosage Growth Defect
ATG18 YFR021W Phosphoinositide binding protein physical 1 1 1 Affinity Capture-MS
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor physical 1 1 1 Affinity Capture-MS
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RAI1 YGL246C Nuclear decapping endonuclease physical 1 1 1 Affinity Capture-MS
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Lethality
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Phenotypic Enhancement
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Reconstituted Complex
BGL2 YGR282C Endo-beta-1,3-glucanase physical 1 1 1 Affinity Capture-MS
AVT4 YNL101W Vacuolar transporter physical 1 1 1 Affinity Capture-MS
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Dosage Rescue
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-MS
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Phenotypic Enhancement
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Dosage Rescue
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex genetic 1 1 1 Synthetic Rescue
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Synthetic Lethality
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Dosage Rescue
DTD1 YDL219W D-Tyr-tRNA(Tyr) deacylase physical 1 1 1 Affinity Capture-MS
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Dosage Lethality
ADO1 YJR105W Adenosine kinase physical 1 1 1 Affinity Capture-MS
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 1 1 1 Affinity Capture-MS
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 Affinity Capture-MS
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
PKH2 YOL100W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
HRT3 YLR097C Putative SCF-ubiquitin ligase F-box protein physical 1 1 1 Affinity Capture-MS
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Dosage Rescue
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Phenotypic Suppression
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
NPA3 YJR072C Member of the conserved GPN-loop GTPase family physical 1 1 1 Affinity Capture-MS
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Affinity Capture-MS
PPE1 YHR075C Protein with carboxyl methyl esterase activity genetic 1 1 1 Positive Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p genetic 1 1 1 Dosage Rescue
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Dosage Rescue
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
HXT5 YHR096C Hexose transporter with moderate affinity for glucose physical 1 1 1 Affinity Capture-MS
NDE1 YMR145C Mitochondrial external NADH dehydrogenase physical 1 1 1 Affinity Capture-MS
RMT2 YDR465C Arginine N5 methyltransferase physical 1 1 1 Affinity Capture-MS
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
DUT1 YBR252W Deoxyuridine triphosphate diphosphatase (dUTPase) genetic 1 1 1 Positive Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Synthetic Rescue
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Dosage Rescue
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Synthetic Rescue
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Synthetic Lethality
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Lethality
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Positive Genetic
RIM11 YMR139W Protein kinase genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Phenotypic Suppression
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Negative Genetic
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Positive Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Phenotypic Suppression
LPP1 YDR503C Lipid phosphate phosphatase genetic 1 1 1 Negative Genetic
SAP4 YGL229C Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Dosage Rescue
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Synthetic Lethality
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides physical 1 1 1 Co-fractionation
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Synthetic Rescue
SER33 YIL074C 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase genetic 1 1 1 Phenotypic Suppression
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Phenotypic Suppression
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Phenotypic Suppression
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Phenotypic Suppression
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Phenotypic Suppression
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Reconstituted Complex
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Positive Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Negative Genetic
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Positive Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Lethality
HHT2 YNL031C Histone H3 genetic 1 1 1 Phenotypic Suppression
RPL11B YGR085C Ribosomal 60S subunit protein L11B physical 1 1 1 Affinity Capture-MS
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Dosage Rescue
HXK1 YFR053C Hexokinase isoenzyme 1 genetic 1 1 1 Positive Genetic
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Synthetic Rescue
GUT1 YHL032C Glycerol kinase genetic 1 1 1 Positive Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Phenotypic Suppression
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
SDS24 YBR214W Protein involved in cell separation during budding physical 1 1 1 Affinity Capture-MS
SDS24 YBR214W Protein involved in cell separation during budding genetic 1 1 1 Synthetic Rescue
ISF1 YMR081C Serine-rich, hydrophilic protein genetic 1 1 1 Synthetic Rescue
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 1 1 1 Synthetic Rescue
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 1 1 1 Synthetic Growth Defect
SCY1 YGL083W Putative kinase genetic 1 1 1 Positive Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Phenotypic Enhancement
FCY22 YER060W-A Putative purine-cytosine permease genetic 1 1 1 Phenotypic Suppression
LCB4 YOR171C Sphingoid long-chain base kinase genetic 1 1 1 Synthetic Rescue
GLC3 YEL011W Glycogen branching enzyme, involved in glycogen accumulation genetic 1 1 1 Phenotypic Suppression
CQD2 YLR253W Mitochondrial protein involved in lipid homeostasis genetic 1 1 1 Negative Genetic
ALK2 YBL009W Atypical protein kinase genetic 1 1 1 Positive Genetic
PHO3 YBR092C Constitutively expressed acid phosphatase similar to Pho5p genetic 1 1 1 Negative Genetic