Standard name Systematic name Name description Description
SHS1 YDL225W Component of the septin ring that is required for cytokinesis Component of the septin ring that is required for cytokinesis; present at the ends of rod-like septin hetero-oligomers; C-terminal extension is important for recruitment of Bni5p to the mother-bud neck, which in turn is required for Myo1p recruitment and cytokinesis; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
Visualize the interactome of SHS1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Bud 0.072 0.080 0.075
Budneck 0.299 0.335 0.219
Budsite 0.269 0.199 0.224
Cort. Patches 0.132 0.153 0.109
Cytoplasm 0.120 0.108 0.109
Mito 0.054 NaN NaN
Nucleolus 0.287 0.148 0.147
SpindlePole NaN 0.062 0.075
Peroxisome NaN NaN 0.134

GFP localization & abundance

GFP localization GFP abundance
bud neck, cell periphery 5620

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SHS1 0 3 3 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 15 6 12 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, FRET, Reconstituted Complex
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 12 5 10 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, PCA
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 9 2 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 9 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 7 5 7 Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring physical 6 3 5 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Affinity Capture-MS
BNI1 YNL271C Formin genetic 6 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 5 3 4 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 4 2 4 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck genetic 4 2 2 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Phenotypic Enhancement
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SMY1 YKL079W Kinesin-like myosin passenger-protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 3 3 2 Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression
RAD53 YPL153C DNA damage response kinase physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 3 2 2 Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 2 2 Synthetic Lethality, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 2 2 Phenotypic Enhancement, Dosage Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 2 2 2 Affinity Capture-MS, Biochemical Activity
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
AXL2 YIL140W Integral plasma membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 2 1 2 Negative Genetic, Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 2 1 2 Negative Genetic, Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 2 1 2 Negative Genetic, Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 2 1 2 Negative Genetic, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 1 2 Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 1 2 Negative Genetic, Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
MET6 YER091C Cobalamin-independent methionine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 2 1 2 Negative Genetic, Negative Genetic
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 2 1 2 Negative Genetic, Negative Genetic
TPA1 YER049W Prolyl hydroxylase genetic 2 1 2 Negative Genetic, Negative Genetic
SPI1 YER150W GPI-anchored cell wall protein involved in weak acid resistance genetic 2 1 2 Negative Genetic, Negative Genetic
SMT1 YJL147C Translational repressor of the mitochondrial ATP6/8 mRNA genetic 2 1 2 Negative Genetic, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Negative Genetic, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 2 1 2 Negative Genetic, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 2 1 2 Negative Genetic, Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 2 1 2 Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 2 1 2 Negative Genetic, Negative Genetic
SSO1 YPL232W Plasma membrane t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 2 Negative Genetic, Negative Genetic
FMP10 YER182W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 2 1 2 Negative Genetic, Negative Genetic
NBA1 YOL070C Protein involved in axial bud site selection genetic 2 1 2 Negative Genetic, Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 2 1 2 Positive Genetic, Positive Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 2 1 2 Negative Genetic, Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 1 2 Negative Genetic, Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 2 1 2 Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Negative Genetic, Negative Genetic
BCS1 YDR375C Protein translocase and chaperone required for Complex III assembly genetic 2 1 2 Negative Genetic, Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
NCW2 YLR194C GPI-anchored protein involved in cell wall remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 2 1 2 Positive Genetic, Positive Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 2 1 2 Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 2 1 2 Negative Genetic, Negative Genetic
PAU8 YAL068C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 2 1 2 Positive Genetic, Positive Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 2 1 2 Negative Genetic, Negative Genetic
COM2 YER130C Transcription factor that binds IME1 Upstream Activation Signal (UAS) genetic 2 1 2 Negative Genetic, Negative Genetic
CSI2 YOL007C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 2 1 2 Negative Genetic, Negative Genetic
MRX8 YDR336W Protein that associates with mitochondrial ribosome genetic 2 1 2 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 2 1 Positive Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 2 2 1 PCA, Reconstituted Complex
VHS2 YIL135C Regulator of septin dynamics genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
NIS1 YNL078W Protein involved in axial bud site selection physical 2 2 1 Affinity Capture-Western, Two-hybrid
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 2 1 Positive Genetic, Negative Genetic
EPO1 YMR124W Protein involved in septin-ER tethering physical 2 2 1 PCA, Reconstituted Complex
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
PHO2 YDL106C Homeobox transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Biochemical Activity
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Dosage Lethality
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Dosage Growth Defect
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Positive Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Positive Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Positive Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 1 1 1 Affinity Capture-MS
ARC35 YNR035C Subunit of the ARP2/3 complex physical 1 1 1 Affinity Capture-MS
ARP2 YDL029W Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Proximity Label-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Dosage Growth Defect
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Positive Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KGD2 YDR148C Dihydrolipoyl transsuccinylase physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis physical 1 1 1 Affinity Capture-MS
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
KCC4 YCL024W Protein kinase of the bud neck involved in the septin checkpoint physical 1 1 1 Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Negative Genetic
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
BGL2 YGR282C Endo-beta-1,3-glucanase physical 1 1 1 Affinity Capture-MS
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Positive Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Positive Genetic
FUN19 YAL034C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) physical 1 1 1 Biochemical Activity
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
GID7 YCL039W Subunit of GID Complex that binds directly to central component Vid30p physical 1 1 1 Affinity Capture-MS
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Lethality
LIA1 YJR070C Deoxyhypusine hydroxylase physical 1 1 1 Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
YHR033W YHR033W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SPA2 YLL021W Component of the polarisome physical 1 1 1 Two-hybrid
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Phenotypic Enhancement
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 1 1 1 PCA
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 1 1 1 PCA
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SIZ1 YDR409W SUMO E3 ligase physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
YDR222W YDR222W Protein of unknown function genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
ZRC1 YMR243C Vacuolar membrane zinc transporter genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Dosage Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Dosage Lethality
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Dosage Growth Defect
VHS1 YDR247W Cytoplasmic serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Positive Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Positive Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Positive Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Positive Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 1 1 1 Positive Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Positive Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
YIA6 YIL006W Mitochondrial NAD+ transporter genetic 1 1 1 Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Positive Genetic
MIH1 YMR036C Protein tyrosine phosphatase genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Synthetic Growth Defect
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Lethality
RRP3 YHR065C Protein involved in rRNA processing genetic 1 1 1 Negative Genetic
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 1 1 1 PCA
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Growth Defect
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Positive Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Negative Genetic
NBA1 YOL070C Protein involved in axial bud site selection physical 1 1 1 Affinity Capture-Western
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Positive Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Negative Genetic
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-Western
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
BUD4 YJR092W Anillin-like protein involved in bud-site selection physical 1 1 1 Affinity Capture-MS
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Synthetic Growth Defect
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
PRK1 YIL095W Ser/Thr protein kinase genetic 1 1 1 Dosage Growth Defect
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
MKC7 YDR144C GPI-anchored aspartyl protease genetic 1 1 1 Negative Genetic
IQG1 YPL242C Actin filament binding protein that enhances actin ring formation genetic 1 1 1 Synthetic Lethality
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Positive Genetic
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p physical 1 1 1 Biochemical Activity
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) physical 1 1 1 Affinity Capture-RNA
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Dosage Growth Defect
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Negative Genetic
LIP5 YOR196C Protein involved in biosynthesis of the coenzyme lipoic acid genetic 1 1 1 Negative Genetic
RGL1 YPL066W Regulator of Rho1p signaling, cofactor of Tus1p genetic 1 1 1 Negative Genetic
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
KTR6 YPL053C Probable mannosylphosphate transferase genetic 1 1 1 Negative Genetic
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
FRE8 YLR047C Protein with sequence similarity to iron/copper reductases genetic 1 1 1 Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Negative Genetic
EMI1 YDR512C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
LDO45 YMR147W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
CYT2 YKL087C Cytochrome c1 heme lyase genetic 1 1 1 Negative Genetic
DPI34 YOR114W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
EMP65 YER140W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
KCH1 YJR054W Potassium transporter that mediates K+ influx genetic 1 1 1 Positive Genetic
PUG1 YER185W Plasma membrane protein involved in protoprophyrin and heme transport genetic 1 1 1 Negative Genetic
FHN1 YGR131W Protein of unknown function genetic 1 1 1 Negative Genetic