Standard name Systematic name Name description Description
SSF1 YHR066W Constituent of 66S pre-ribosomal particles Constituent of 66S pre-ribosomal particles; required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family; SSF1 has a paralog, SSF2, that arose from the whole genome duplication
Visualize the interactome of SSF1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.185 NaN 0.059
Nucleolus 0.705 0.667 0.825
Nucleus 0.289 0.403 0.122
SpindlePole NaN NaN 0.069

GFP localization & abundance

GFP localization GFP abundance
nucleolus, nucleus 8150

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SSF1 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
NOG1 YPL093W Putative GTPase physical 10 2 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
NOP7 YGR103W Component of several different pre-ribosomal particles physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
MAK21 YDR060W Constituent of 66S pre-ribosomal particles physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 7 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 7 1 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
HAS1 YMR290C ATP-dependent RNA helicase physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SSF2 YDR312W Protein required for ribosomal large subunit maturation genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 5 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NSA1 YGL111W Constituent of 66S pre-ribosomal particles physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPL35A YDL191W Ribosomal 60S subunit protein L35A physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RRP15 YPR143W Nucleolar protein physical 4 2 3 Affinity Capture-MS, Two-hybrid, Two-hybrid, Two-hybrid
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RSA3 YLR221C Protein with a likely role in ribosomal maturation genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
ERB1 YMR049C Constituent of 66S pre-ribosomal particles physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
NOP2 YNL061W rRNA m5C methyltransferase physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPF1 YHR088W Protein involved in assembly and export of the large ribosomal subunit physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Co-purification
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CIC1 YHR052W Essential protein that interacts with proteasome components physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PUF6 YDR496C Pumilio-homology domain protein physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
NOP16 YER002W Constituent of 66S pre-ribosomal particles genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NOC2 YOR206W Protein involved in ribosome biogenesis physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MTR4 YJL050W RNA duplex-sensing translocase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EUC1 YMR111C Sequence-specific DNA binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARO3 YDR035W 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL26B YGR034W Ribosomal 60S subunit protein L26B genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
REX4 YOL080C Putative RNA exonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 2 2 2 PCA, Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
STE4 YOR212W G protein beta subunit genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
MAK5 YBR142W Essential nucleolar protein physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Rescue, Positive Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NOP4 YPL043W Nucleolar protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSF1 YHR066W Constituent of 66S pre-ribosomal particles physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
URB1 YKL014C Protein required for the normal accumulation of 25S and 5.8S rRNAs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 2 1 2 Positive Genetic, Positive Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 1 2 Negative Genetic, Negative Genetic
YLR407W YLR407W Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 2 Negative Genetic, Negative Genetic
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Positive Genetic, Positive Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 2 1 2 Negative Genetic, Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 2 1 2 Positive Genetic, Positive Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 2 1 2 Positive Genetic, Positive Genetic
ATG3 YNR007C E2-like enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Positive Genetic, Positive Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 2 1 2 Negative Genetic, Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RPL35B YDL136W Ribosomal 60S subunit protein L35B physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
AIM39 YOL053W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 2 1 2 Positive Genetic, Positive Genetic
MSN1 YOL116W Transcriptional activator genetic 2 1 2 Negative Genetic, Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 2 1 1 Negative Genetic, Negative Genetic
ECM2 YBR065C Pre-mRNA splicing factor genetic 2 1 1 Negative Genetic, Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 2 1 1 Negative Genetic, Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
DIS3 YOL021C Exosome core complex catalytic subunit genetic 2 1 1 Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 1 1 Negative Genetic, Negative Genetic
MAK5 YBR142W Essential nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 1 Positive Genetic, Positive Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 2 1 1 Negative Genetic, Negative Genetic
SAM2 YDR502C S-adenosylmethionine synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 2 1 1 Negative Genetic, Negative Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Positive Genetic
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
BRX1 YOL077C Nucleolar protein physical 1 1 1 Affinity Capture-MS
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase genetic 1 1 1 Negative Genetic
NOP16 YER002W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
NOP4 YPL043W Nucleolar protein genetic 1 1 1 Negative Genetic
NSA1 YGL111W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 physical 1 1 1 Affinity Capture-MS
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Positive Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
RPL17A YKL180W Ribosomal 60S subunit protein L17A physical 1 1 1 Affinity Capture-MS
RPL27A YHR010W Ribosomal 60S subunit protein L27A physical 1 1 1 Affinity Capture-MS
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
RPL32 YBL092W Ribosomal 60S subunit protein L32 physical 1 1 1 Affinity Capture-MS
RPL38 YLR325C Ribosomal 60S subunit protein L38 physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
SSF2 YDR312W Protein required for ribosomal large subunit maturation physical 1 1 1 Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Dosage Rescue
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Positive Genetic
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
YNG1 YOR064C Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Positive Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Positive Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
YAL064W YAL064W Protein of unknown function genetic 1 1 1 Positive Genetic
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm genetic 1 1 1 Negative Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJR056C YJR056C Protein of unknown function genetic 1 1 1 Negative Genetic
YKL096C-B YKL096C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSP120 YLR250W Protein packaged into COPII vesicles for ER to Golgi trafficking genetic 1 1 1 Negative Genetic
YMR030W-A YMR030W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL146W YNL146W Putative protein of unknown function genetic 1 1 1 Negative Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
KAP123 YER110C Karyopherin beta physical 1 1 1 Affinity Capture-MS
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-Western
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Negative Genetic
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes genetic 1 1 1 Negative Genetic
NAF1 YNL124W RNA-binding protein required for the assembly of box H/ACA snoRNPs genetic 1 1 1 Negative Genetic
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
LOC1 YFR001W Nucleolar protein involved in the asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-Western
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Positive Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Negative Genetic
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP45 YDR280W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
NPL6 YMR091C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing physical 1 1 1 Affinity Capture-Western
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Phenotypic Suppression
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) physical 1 1 1 Affinity Capture-MS
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Phenotypic Suppression
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
DBP10 YDL031W Putative ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Negative Genetic
NSA2 YER126C Protein constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-Western
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs physical 1 1 1 Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Positive Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Positive Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor genetic 1 1 1 Positive Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-Western
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Positive Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Dosage Rescue
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Positive Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
NMD5 YJR132W Karyopherin genetic 1 1 1 Positive Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Positive Genetic
LCP5 YER127W Essential protein involved in maturation of 18S rRNA genetic 1 1 1 Positive Genetic
PXR1 YGR280C Essential protein involved in rRNA and snoRNA maturation physical 1 1 1 Affinity Capture-Western
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
ADH4 YGL256W Alcohol dehydrogenase isoenzyme type IV genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-Western
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 physical 1 1 1 Affinity Capture-Western
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
DIA2 YOR080W Origin-binding F-box protein physical 1 1 1 Affinity Capture-MS
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Phenotypic Enhancement
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
AIR1 YIL079C Zinc knuckle protein genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Positive Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
RPL5 YPL131W Ribosomal 60S subunit protein L5 physical 1 1 1 Affinity Capture-Western
RPL5 YPL131W Ribosomal 60S subunit protein L5 genetic 1 1 1 Positive Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
ATG13 YPR185W Regulatory subunit of the Atg1p signaling complex genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase genetic 1 1 1 Negative Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Positive Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Positive Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Positive Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
ATG8 YBL078C Ub-like protein genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
GAD1 YMR250W Glutamate decarboxylase genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Dosage Rescue
RPL1B YGL135W Ribosomal 60S subunit protein L1B physical 1 1 1 Affinity Capture-Western
ADY4 YLR227C Structural component of the meiotic outer plaque genetic 1 1 1 Negative Genetic
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Positive Genetic
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
ERT1 YBR239C Transcriptional regulator genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Positive Genetic
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Positive Genetic
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Positive Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family physical 1 1 1 Affinity Capture-MS
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
MRP35 YNL122C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
RRP15 YPR143W Nucleolar protein genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Negative Genetic
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
ABZ2 YMR289W Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase) genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SDD3 YOL098C Putative metalloprotease genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-Western
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-Western
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 1 1 1 Negative Genetic
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
HVG1 YER039C Protein of unknown function genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Negative Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Negative Genetic
PRY1 YJL079C Lipid binding protein genetic 1 1 1 Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 1 1 1 Positive Genetic
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
SET6 YPL165C SET domain protein of unknown function genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
RPL33A YPL143W Ribosomal 60S subunit protein L33A genetic 1 1 1 Negative Genetic
EFM4 YIL064W Lysine methyltransferase genetic 1 1 1 Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
MOD5 YOR274W Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Positive Genetic
PEX9 YMR018W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic