Standard name Systematic name Name description Description
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; regulates levels of DNA Polymerase-{alpha} to promote efficient and accurate DNA replication
Visualize the interactome of MOT2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.989 0.958 1.0

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 4280

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MOT2 7 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 19 7 15 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Co-purification, PCA, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 12 5 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-RNA, Co-purification, Affinity Capture-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 12 3 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 9 5 9 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 9 4 9 Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 7 4 7 Affinity Capture-Western, Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 7 4 7 Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 6 4 6 Affinity Capture-Western, PCA, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 5 3 5 PCA, Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
UBC5 YDR059C Ubiquitin-conjugating enzyme physical 5 2 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex physical 4 3 4 Two-hybrid, Affinity Capture-MS, Co-purification, Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 4 3 2 Biochemical Activity, Co-fractionation, Affinity Capture-Western, Biochemical Activity
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 3 2 3 Dosage Rescue, Dosage Rescue, Synthetic Lethality
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 3 2 3 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 3 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 3 3 2 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 3 2 2 Dosage Rescue, Synthetic Lethality, Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 3 3 1 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
DEF1 YKL054C RNAPII degradation factor physical 2 2 2 PCA, Affinity Capture-MS
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex physical 2 2 2 Affinity Capture-Western, Biochemical Activity
UBP6 YFR010W Ubiquitin-specific protease genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Negative Genetic, Dosage Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
JHD2 YJR119C JmjC domain family histone demethylase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
DOA4 YDR069C Ubiquitin hydrolase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
ECM29 YHL030W Scaffold protein genetic 2 2 1 Synthetic Lethality, Phenotypic Suppression
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
ARF1 YDL192W ADP-ribosylation factor genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) physical 2 2 1 Two-hybrid, Affinity Capture-Western
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 2 2 1 Affinity Capture-Western, Biochemical Activity
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
YOR302W YOR302W CPA1 uORF genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DST1 YGL043W General transcription elongation factor TFIIS physical 2 1 1 Reconstituted Complex, Reconstituted Complex
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 2 1 1 Reconstituted Complex, Reconstituted Complex
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
JHD2 YJR119C JmjC domain family histone demethylase regulation 1 1 1 ubiquitination assay evidence
SPT2 YER161C Protein involved in negative regulation of transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPN1 YPR133C Protein involved in RNA polymerase II transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NHP6A YPR052C High-mobility group (HMG) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein physical 1 1 1 PCA
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Growth Defect
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Synthetic Rescue
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Lethality
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-Western
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Dosage Growth Defect
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Synthetic Rescue
ECM29 YHL030W Scaffold protein physical 1 1 1 Affinity Capture-Western
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Synthetic Growth Defect
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity genetic 1 1 1 Phenotypic Enhancement
BLM10 YFL007W Proteasome activator genetic 1 1 1 Synthetic Growth Defect
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Lethality
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
LTV1 YKL143W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Synthetic Growth Defect
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
CAF120 YNL278W Part of the CCR4-NOT transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
CAF120 YNL278W Part of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Synthetic Growth Defect
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
GUF1 YLR289W Mitochondrial matrix GTPase genetic 1 1 1 Synthetic Lethality
ATG7 YHR171W Autophagy-related protein and dual specificity member of the E1 family genetic 1 1 1 Synthetic Growth Defect
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Synthetic Lethality
HSL7 YBR133C Protein arginine N-methyltransferase genetic 1 1 1 Synthetic Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Lethality
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Positive Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Synthetic Lethality
IGO1 YNL157W Protein required for initiation of G0 program physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
JSN1 YJR091C Member of the Puf family of RNA-binding proteins physical 1 1 1 PCA
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Negative Genetic
BMT2 YBR141C Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
IKI1 YHR187W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Synthetic Growth Defect
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Lethality
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage physical 1 1 1 PCA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 PCA
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 PCA
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects physical 1 1 1 PCA
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Affinity Capture-Western
SKI6 YGR195W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-Western
RRP42 YDL111C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-Western
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Two-hybrid
SAM1 YLR180W S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
SAM2 YDR502C S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Reconstituted Complex
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor physical 1 1 1 Affinity Capture-Western
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-RNA
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Growth Defect
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Biochemical Activity
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Affinity Capture-Western
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Biochemical Activity
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Synthetic Growth Defect
STE4 YOR212W G protein beta subunit genetic 1 1 1 Synthetic Rescue
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Rescue
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Suppression
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
NHP6B YBR089C-A High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
PIB1 YDR313C RING-type ubiquitin ligase of the endosomal and vacuolar membranes genetic 1 1 1 Synthetic Lethality
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Synthetic Lethality
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Synthetic Lethality
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Synthetic Lethality
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Synthetic Lethality
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) genetic 1 1 1 Synthetic Lethality
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Synthetic Lethality
PPN1 YDR452W Dual endo- and exopolyphosphatase with a role in phosphate metabolism genetic 1 1 1 Synthetic Lethality
YKR005C YKR005C Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
NNT1 YLR285W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Synthetic Growth Defect
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Growth Defect
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Synthetic Growth Defect
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Synthetic Lethality
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Lethality
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
YMR085W YMR085W Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Synthetic Lethality
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Negative Genetic
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
MSS18 YPR134W Nuclear encoded protein needed for splicing of mitochondrial intron genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Positive Genetic
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Positive Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Positive Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Positive Genetic
NOC4 YPR144C Nucleolar protein genetic 1 1 1 Positive Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Positive Genetic
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Growth Defect
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Dosage Growth Defect
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Dosage Growth Defect
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Dosage Growth Defect
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Dosage Growth Defect
TDA9 YML081W Transcription factor that regulates acetate production genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
RPL13B YMR142C Ribosomal 60S subunit protein L13B genetic 1 1 1 Synthetic Growth Defect
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Synthetic Growth Defect
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Enhancement
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Synthetic Rescue
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Phenotypic Enhancement
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Rescue
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
JHD2 YJR119C JmjC domain family histone demethylase physical 1 1 1 Biochemical Activity
AEP3 YPL005W Peripheral mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Phenotypic Enhancement
LOT5 YKL183W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Synthetic Growth Defect
MAK32 YCR019W Protein necessary for stability of L-A dsRNA-containing particles genetic 1 1 1 Negative Genetic
MOD5 YOR274W Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase genetic 1 1 1 Positive Genetic