Standard name Systematic name Name description Description
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response; single DOT1 gene produces two Dot1p isoforms from alternative translation start sites as a result of leaky scanning by the ribosome
Visualize the interactome of DOT1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1/S 44

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.273 NaN NaN
Nucleus 0.909 0.926 NaN
Vac/Vac Memb NaN 0.083 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 2160

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
DOT1 9 0 0 6 0

Enzyme information

Catalyzed reactions in Yeast8
r_4193 (S-Adenosyl-L-methionine:histone-L-lysine N6-methyltransferase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HHT1 YBR010W Histone H3 physical 10 4 9 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Co-crystal Structure
HHT2 YNL031C Histone H3 physical 9 3 8 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex
POL32 YJR043C Third subunit of DNA polymerase delta genetic 8 3 5 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 6 5 5 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 6 3 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
SLX4 YLR135W Endonuclease involved in processing DNA genetic 5 2 5 Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 4 4 4 Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
HHF1 YBR009C Histone H4 physical 4 4 3 Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Biochemical Activity
DPB11 YJL090C DNA replication initiation protein genetic 4 3 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FRK1 YPL141C Protein kinase of unknown cellular role genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SIR3 YLR442C Silencing protein genetic 3 3 3 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 3 3 3 Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement
REV1 YOR346W Deoxycytidyl transferase genetic 3 2 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 3 2 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
AKL1 YBR059C Ser/Thr protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 3 2 Synthetic Rescue, Positive Genetic, Phenotypic Suppression
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TGL4 YKR089C Multifunctional lipase/hydrolase/phospholipase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DLD1 YDL174C Major mitochondrial D-lactate dehydrogenase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 2 Synthetic Haploinsufficiency, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
HHF2 YNL030W Histone H4 physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
HTB1 YDR224C Histone H2B physical 2 2 2 Reconstituted Complex, Co-crystal Structure
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 2 2 Negative Genetic, Phenotypic Suppression
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CDC21 YOR074C Thymidylate synthase genetic 2 1 2 Dosage Rescue, Dosage Rescue
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 2 1 2 Co-localization, Co-localization
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RIF1 YBR275C Protein involved in control of DNA replication genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 2 1 2 Negative Genetic, Negative Genetic
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 2 1 2 Negative Genetic, Negative Genetic
FAT3 YKL187C Protein required for fatty acid uptake genetic 2 1 2 Negative Genetic, Negative Genetic
YOR008C-A YOR008C-A Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 2 1 2 Negative Genetic, Negative Genetic
TEX1 YNL253W Protein involved in mRNA export genetic 2 1 2 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
HOP1 YIL072W Meiosis-specific protein required for chromosome synapsis genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin physical 2 2 1 Far Western, Affinity Capture-Western
RAD53 YPL153C DNA damage response kinase genetic 2 2 1 Synthetic Growth Defect, Dosage Growth Defect
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex genetic 2 1 1 Negative Genetic, Negative Genetic
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT genetic 2 1 1 Negative Genetic, Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 2 1 1 Negative Genetic, Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 2 1 1 Negative Genetic, Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 2 1 1 Negative Genetic, Negative Genetic
QCR10 YHR001W-A Subunit of the ubiqunol-cytochrome c oxidoreductase complex genetic 2 1 1 Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 2 1 1 Negative Genetic, Negative Genetic
DPI35 YMR130W Putative mitochondrial protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 1 Negative Genetic, Negative Genetic
TOM70 YNL121C Component of the TOM (translocase of outer membrane) complex genetic 2 1 1 Negative Genetic, Negative Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 2 1 1 Negative Genetic, Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 2 1 1 Negative Genetic, Negative Genetic
DCR2 YLR361C Protein phosphatase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response regulation 1 1 1 DNA to cDNA expression microarray evidence
ARN1 YHL040C ARN family transporter for siderophore-iron chelates regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
SIT1 YEL065W Ferrioxamine B transporter regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
PHO5 YBR093C Repressible acid phosphatase regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Rescue
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
COX4 YGL187C Subunit IV of cytochrome c oxidase genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Dosage Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Positive Genetic
CWC24 YLR323C General splicing factor genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Synthetic Rescue
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Synthetic Rescue
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
BNR1 YIL159W Formin genetic 1 1 1 Negative Genetic
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Two-hybrid
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Growth Defect
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Growth Defect
SIR3 YLR442C Silencing protein physical 1 1 1 Co-localization
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-MS
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 Affinity Capture-MS
IMH1 YLR309C Protein involved in vesicular transport physical 1 1 1 Affinity Capture-MS
INP52 YNL106C Polyphosphatidylinositol phosphatase physical 1 1 1 Affinity Capture-MS
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Rescue
HHF2 YNL030W Histone H4 genetic 1 1 1 Phenotypic Suppression
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex physical 1 1 1 Affinity Capture-Western
HTA1 YDR225W Histone H2A physical 1 1 1 Reconstituted Complex
HTA2 YBL003C Histone H2A physical 1 1 1 Reconstituted Complex
HTB2 YBL002W Histone H2B physical 1 1 1 Reconstituted Complex
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Synthetic Lethality
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Lethality
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Phenotypic Enhancement
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Phenotypic Enhancement
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
RAD24 YER173W Checkpoint protein genetic 1 1 1 Synthetic Growth Defect
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Rescue
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Rescue
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Synthetic Rescue
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Synthetic Rescue
SUA5 YGL169W Protein involved in threonylcarbamoyl adenosine biosynthesis genetic 1 1 1 Phenotypic Enhancement
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Phenotypic Enhancement
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Phenotypic Enhancement
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Phenotypic Enhancement
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Phenotypic Enhancement
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
TCB1 YOR086C Lipid-binding ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Positive Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Synthetic Growth Defect
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Synthetic Rescue
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Phenotypic Suppression
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Dosage Growth Defect
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Synthetic Growth Defect
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 1 1 1 Phenotypic Suppression
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Synthetic Growth Defect
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Positive Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein genetic 1 1 1 Positive Genetic
ECM4 YKR076W S-glutathionyl-(chloro)hydroquinone reductase (GS-HQR) genetic 1 1 1 Positive Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 1 1 1 Positive Genetic
MIX17 YMR002W Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
ERR1 YOR393W Putative phosphopyruvate hydratase genetic 1 1 1 Positive Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
FMT1 YBL013W Methionyl-tRNA formyltransferase genetic 1 1 1 Negative Genetic
SEF1 YBL066C Putative transcription factor genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
MET8 YBR213W Bifunctional dehydrogenase and ferrochelatase genetic 1 1 1 Negative Genetic
SLX1 YBR228W Endonuclease involved in DNA recombination and repair genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDR061W YDR061W Protein with similarity to ABC transporter family members genetic 1 1 1 Negative Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
RKM4 YDR257C Ribosomal lysine methyltransferase genetic 1 1 1 Negative Genetic
PPE1 YHR075C Protein with carboxyl methyl esterase activity genetic 1 1 1 Negative Genetic
LAC1 YKL008C Ceramide synthase component genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
LDO16 YMR148W Protein of unknown function with possible role in spore wall assembly genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
DSE1 YER124C Daughter cell-specific protein genetic 1 1 1 Negative Genetic
YER152C YER152C Protein with 2-aminoadipate transaminase activity genetic 1 1 1 Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function genetic 1 1 1 Negative Genetic
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Negative Genetic
FAU1 YER183C 5,10-methenyltetrahydrofolate synthetase genetic 1 1 1 Negative Genetic
RPO41 YFL036W Mitochondrial RNA polymerase genetic 1 1 1 Negative Genetic
YMR31 YFR049W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase genetic 1 1 1 Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
PEF1 YGR058W Penta-EF-hand protein genetic 1 1 1 Negative Genetic
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 genetic 1 1 1 Negative Genetic
PEX21 YGR239C Peroxin required for peroxisomal matrix protein targeting genetic 1 1 1 Negative Genetic
RIM4 YHL024W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
TCD1 YHR003C tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
YSC83 YHR017W Non-essential mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
SMN1 YHR202W Putative AMP hydrolase genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 1 1 1 Negative Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YJR120W YJR120W Protein of unknown function genetic 1 1 1 Negative Genetic
YJR151W-A YJR151W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
SMY1 YKL079W Kinesin-like myosin passenger-protein genetic 1 1 1 Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Negative Genetic
GLG1 YKR058W Glycogenin glucosyltransferase genetic 1 1 1 Negative Genetic
SKG1 YKR100C Transmembrane protein with a role in cell wall polymer composition genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
FRE1 YLR214W Ferric reductase and cupric reductase genetic 1 1 1 Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
MOT3 YMR070W Transcriptional repressor, activator genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase genetic 1 1 1 Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
MPD2 YOL088C Member of the protein disulfide isomerase (PDI) family genetic 1 1 1 Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily genetic 1 1 1 Negative Genetic
YNG1 YOR064C Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
TRS33 YOR115C Core component of TRAPP complexes I, II and IV genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p genetic 1 1 1 Negative Genetic
MRX21 YPR011C Mitochondrial transporter genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Suppression
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Phenotypic Suppression
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Dosage Growth Defect
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Rescue
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Rescue
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Rescue
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Synthetic Rescue
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Phenotypic Enhancement
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Rescue
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
DDR48 YMR173W DNA damage-responsive protein genetic 1 1 1 Positive Genetic
CSA1 YPR174C Protein of unknown function genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Phenotypic Enhancement
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 1 1 1 Negative Genetic
CSS3 YOL159C Protein of unknown function, secreted when constitutively expressed genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Negative Genetic