Standard name Systematic name Name description Description
MCM2 YBL023C Protein involved in DNA replication Protein involved in DNA replication; component of the Mcm2-7 hexameric helicase complex that binds chromatin as a part of the pre-replicative complex; relative distribution to the nucleus increases upon DNA replication stress
Visualize the interactome of MCM2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 26

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.193 0.306 0.249
Nucleolus 0.092 NaN 0.143
Nucleus 0.679 0.582 0.534
Vac/Vac Memb NaN 0.067 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1690

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MCM2 1 0 0 0 4

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 27 7 22 Co-localization, Co-localization, Co-fractionation, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC45 YLR103C DNA replication initiation factor physical 25 5 19 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
MCM3 YEL032W Protein involved in DNA replication physical 18 5 14 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
MCM6 YGL201C Protein involved in DNA replication physical 17 6 13 Co-localization, Co-fractionation, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 16 3 14 Affinity Capture-Western, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
MCM10 YIL150C Essential chromatin-associated protein physical 16 5 10 Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Co-purification, Reconstituted Complex, Co-localization
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 12 6 12 Affinity Capture-Western, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
TAH11 YJR046W DNA replication licensing factor physical 12 2 10 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 10 4 10 Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex physical 9 4 6 Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 8 2 8 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex physical 8 6 7 Co-localization, Co-fractionation, Co-purification, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SLD3 YGL113W Protein involved in the initiation of DNA replication physical 8 3 6 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 7 4 5 Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 6 2 6 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 6 4 5 Phenotypic Enhancement, Synthetic Rescue, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue
CDC6 YJL194W Essential ATP-binding protein required for DNA replication physical 6 3 5 Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 6 4 4 Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Growth Defect
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 5 1 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 5 3 3 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 5 2 3 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 5 2 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ORC5 YNL261W Subunit of the origin recognition complex (ORC) physical 4 3 4 Co-fractionation, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
CSM3 YMR048W Replication fork associated factor physical 4 1 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
MCM3 YEL032W Protein involved in DNA replication genetic 4 4 3 Dosage Lethality, Synthetic Lethality, Phenotypic Enhancement, Dosage Growth Defect
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 4 3 3 Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein physical 4 3 3 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 4 3 3 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 4 3 3 Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
HHT1 YBR010W Histone H3 physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
MCM10 YIL150C Essential chromatin-associated protein genetic 4 3 2 Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality
CTF4 YPR135W Chromatin-associated protein genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 3 3 3 Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) physical 3 3 3 Co-fractionation, Affinity Capture-Western, Reconstituted Complex
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 3 2 3 Synthetic Rescue, Negative Genetic, Negative Genetic
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
HHF1 YBR009C Histone H4 physical 3 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
HTA1 YDR225W Histone H2A physical 3 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
HTA2 YBL003C Histone H2A physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
MCM2 YBL023C Protein involved in DNA replication physical 3 2 2 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
DPB11 YJL090C DNA replication initiation protein physical 3 2 2 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HTB2 YBL002W Histone H2B physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
HHT2 YNL031C Histone H3 physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Co-fractionation
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 2 2 Synthetic Rescue, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
CTF4 YPR135W Chromatin-associated protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 2 1 2 Negative Genetic, Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex physical 2 1 2 Reconstituted Complex, Reconstituted Complex
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 2 1 2 Reconstituted Complex, Reconstituted Complex
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RAD53 YPL153C DNA damage response kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
HHF2 YNL030W Histone H4 physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
CHL1 YPL008W Probable DNA helicase genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion physical 2 2 1 Two-hybrid, Reconstituted Complex
BMH2 YDR099W 14-3-3 protein, minor isoform physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SKN1 YGR143W Protein involved in sphingolipid biosynthesis genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Negative Genetic, Negative Genetic
PDS1 YDR113C Securin genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
BUD23 YCR047C Ribosome biogenesis factor genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Synthetic Lethality
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes physical 1 1 1 Co-fractionation
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Affinity Capture-MS
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Lethality
CTF18 YMR078C Subunit of a complex with Ctf8p physical 1 1 1 Affinity Capture-Western
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Phenotypic Enhancement
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B physical 1 1 1 Two-hybrid
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Rescue
HHF2 YNL030W Histone H4 genetic 1 1 1 Synthetic Rescue
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
MBP1 YDL056W Transcription factor genetic 1 1 1 Synthetic Rescue
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) physical 1 1 1 Affinity Capture-MS
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-Western
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
PRP3 YDR473C Splicing factor physical 1 1 1 Two-hybrid
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone physical 1 1 1 Two-hybrid
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
PRI1 YIR008C Subunit of DNA primase physical 1 1 1 Affinity Capture-Western
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes physical 1 1 1 Co-fractionation
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) physical 1 1 1 Reconstituted Complex
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 1 1 1 Two-hybrid
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex physical 1 1 1 Affinity Capture-Western
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Lethality
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Synthetic Lethality
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Rescue
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase genetic 1 1 1 Synthetic Rescue
RAD2 YGR258C Single-stranded DNA endonuclease genetic 1 1 1 Synthetic Rescue
PDR15 YDR406W Plasma membrane ATP binding cassette (ABC) transporter genetic 1 1 1 Synthetic Rescue
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis genetic 1 1 1 Synthetic Rescue
YHP1 YDR451C Homeobox transcriptional repressor genetic 1 1 1 Synthetic Rescue
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Rescue
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Synthetic Rescue
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Rescue
SIP18 YMR175W Phospholipid-binding hydrophilin genetic 1 1 1 Synthetic Rescue
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Synthetic Rescue
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Positive Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Positive Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
YJL163C YJL163C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SPO1 YNL012W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
MNE1 YOR350C Protein involved in splicing Group I aI5-beta intron from COX1 mRNA genetic 1 1 1 Negative Genetic
MXR1 YER042W Methionine-S-sulfoxide reductase genetic 1 1 1 Negative Genetic
YJL136W-A YJL136W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Phenotypic Suppression
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
KIN1 YDR122W S/T protein kinase physical 1 1 1 Two-hybrid
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Dosage Lethality
KIN2 YLR096W S/T protein kinase physical 1 1 1 Two-hybrid
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Biochemical Activity
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Biochemical Activity
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating physical 1 1 1 Biochemical Activity
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Biochemical Activity
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Positive Genetic
CHL1 YPL008W Probable DNA helicase physical 1 1 1 Affinity Capture-Western
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase physical 1 1 1 Affinity Capture-MS
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Affinity Capture-MS
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 1 1 1 Synthetic Rescue
ETT1 YOR051C Nuclear protein that inhibits replication of Brome mosaic virus genetic 1 1 1 Synthetic Rescue
FAF1 YIL019W Protein required for pre-rRNA processing genetic 1 1 1 Negative Genetic
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Lethality
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
AIM39 YOL053W Protein of unknown function genetic 1 1 1 Negative Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
FAD1 YDL045C Flavin adenine dinucleotide (FAD) synthetase genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells genetic 1 1 1 Negative Genetic
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Negative Genetic