Standard name Systematic name Name description Description
MOT3 YMR070W Transcriptional repressor, activator Transcriptional repressor, activator; role in cellular adjustment to osmotic stress including modulation of mating efficiency; involved in repression of subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, ergosterol biosynthetic genes in response to hyperosmotic stress; contributes to recruitment of Tup1p-Cyc8p general repressor to promoters; relocalizes to cytosol under hypoxia; forms [MOT3+] prion under anaerobic conditions
Visualize the interactome of MOT3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M/G1 182

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.066 NaN 0.167
Nucleolus 0.263 0.188 0.190
Nucleus 0.874 0.884 0.805

GFP localization & abundance

GFP localization GFP abundance
nucleus 1690

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MOT3 7 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
BRE5 YNR051C Ubiquitin protease cofactor genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 4 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 3 2 3 Negative Genetic, Negative Genetic, Positive Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
AGA1 YNR044W Anchorage subunit of a-agglutinin of a-cells regulation 3 3 2 chromatin immunoprecipitation-qPCR evidence, DNA to cDNA expression microarray evidence, northern blot evidence
ARO1 YDR127W Pentafunctional arom protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells regulation 2 2 2 DNA to cDNA expression microarray evidence, northern blot evidence
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane regulation 2 2 2 DNA to cDNA expression microarray evidence, northern blot evidence
MOT3 YMR070W Transcriptional repressor, activator physical 2 2 2 PCA, Reconstituted Complex
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 2 2 2 Protein-RNA, Affinity Capture-RNA
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 2 2 Negative Genetic, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 2 1 2 Negative Genetic, Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 2 1 2 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
LCB1 YMR296C Component of serine palmitoyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase genetic 2 1 2 Negative Genetic, Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 2 Negative Genetic, Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 2 1 2 Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 2 1 2 Negative Genetic, Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 2 1 2 Negative Genetic, Negative Genetic
ARE2 YNR019W Acyl-CoA:sterol acyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 2 1 2 Negative Genetic, Negative Genetic
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 2 1 2 Negative Genetic, Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
AKR1 YDR264C Palmitoyl transferase involved in protein palmitoylation genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Negative Genetic, Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 2 1 2 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 2 Positive Genetic, Positive Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 1 2 Negative Genetic, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 2 1 2 Negative Genetic, Negative Genetic
PSP1 YDR505C Asn and gln rich protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
UTR1 YJR049C ATP-NADH kinase genetic 2 1 2 Negative Genetic, Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 1 2 Negative Genetic, Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 1 2 Negative Genetic, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
MSG5 YNL053W Dual-specificity protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase genetic 2 1 2 Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 2 1 2 Negative Genetic, Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 2 1 2 Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 1 2 Negative Genetic, Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 2 Negative Genetic, Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 2 1 2 Negative Genetic, Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 2 Negative Genetic, Negative Genetic
GRE1 YPL223C Hydrophilin essential in desiccation-rehydration process regulation 2 2 1 chromatin immunoprecipitation-qPCR evidence, northern blot evidence
SIP18 YMR175W Phospholipid-binding hydrophilin regulation 2 2 1 chromatin immunoprecipitation-qPCR evidence, northern blot evidence
CRG1 YHR209W S-AdoMet-dependent methyltransferase involved in lipid homeostasis genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
GIS1 YDR096W Histone demethylase and transcription factor physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 1 Negative Genetic, Negative Genetic
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 2 1 1 Negative Genetic, Negative Genetic
MTC7 YEL033W Protein of unknown function genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 2 1 1 Negative Genetic, Negative Genetic
UTR5 YEL035C Protein of unknown function genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARO9 YHR137W Aromatic aminotransferase II regulation 1 1 1 DNA to cDNA expression microarray evidence
PDR11 YIL013C ATP-binding cassette (ABC) transporter regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
HMS1 YOR032C bHLH protein with similarity to myc-family transcription factors regulation 1 1 1 DNA to cDNA expression microarray evidence
NCE103 YNL036W Carbonic anhydrase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
DAN1 YJR150C Cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
TIR3 YIL011W Cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
CWP1 YKL096W Cell wall mannoprotein that localizes to birth scars of daughter cells regulation 1 1 1 DNA to cDNA expression microarray evidence
RRP36 YOR287C Component of 90S preribosomes regulation 1 1 1 DNA to cDNA expression microarray evidence
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing regulation 1 1 1 DNA to cDNA expression microarray evidence
ISU1 YPL135W Conserved protein of the mitochondrial matrix regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHO3 YBR092C Constitutively expressed acid phosphatase similar to Pho5p regulation 1 1 1 DNA to cDNA expression microarray evidence
CWP2 YKL096W-A Covalently linked cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
GIP3 YPL137C Cytoplasmic protein that regulates protein phosphatase 1 Glc7p regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YOL150C YOL150C Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
YHR140W YHR140W Endoplasmic reticulum protein regulation 1 1 1 northern blot evidence
FRE1 YLR214W Ferric reductase and cupric reductase regulation 1 1 1 DNA to cDNA expression microarray evidence
SIT1 YEL065W Ferrioxamine B transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
FIG1 YBR040W Integral membrane protein required for efficient mating regulation 1 1 1 northern blot evidence
PHM8 YER037W Lysophosphatidic acid (LPA) phosphatase, nucleotidase regulation 1 1 1 northern blot evidence
SED1 YDR077W Major stress-induced structural GPI-cell wall glycoprotein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FIT3 YOR383C Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes regulation 1 1 1 DNA to cDNA expression microarray evidence
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator regulation 1 1 1 DNA to cDNA expression microarray evidence
UTH1 YKR042W Mitochondrial inner membrane protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YJL218W YJL218W Mitochondrial protein, putative acetyltransferase regulation 1 1 1 northern blot evidence
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ATO3 YDR384C Plasma membrane protein, putative ammonium transporter regulation 1 1 1 northern blot evidence
AUS1 YOR011W Plasma membrane sterol transporter of the ATP-binding cassette family regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
GUP2 YPL189W Probable membrane protein regulation 1 1 1 DNA to cDNA expression microarray evidence
SPS100 YHR139C Protein required for spore wall maturation regulation 1 1 1 northern blot evidence
ASG7 YJL170C Protein that regulates signaling from G protein beta subunit Ste4p regulation 1 1 1 DNA to cDNA expression microarray evidence
SPL2 YHR136C Protein with similarity to cyclin-dependent kinase inhibitors regulation 1 1 1 DNA to cDNA expression microarray evidence
KNH1 YDL049C Protein with similarity to Kre9p regulation 1 1 1 DNA to cDNA expression microarray evidence
TIR2 YOR010C Putative cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
YHL044W YHL044W Putative integral membrane protein regulation 1 1 1 DNA to cDNA expression microarray evidence
YKL097C YKL097C Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YDL241W YDL241W Putative protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
YHR022C YHR022C Putative protein of unknown function regulation 1 1 1 northern blot evidence
CMS1 YLR003C Putative subunit of the 90S preribosome processome complex regulation 1 1 1 DNA to cDNA expression microarray evidence
RTN2 YDL204W Reticulon protein regulation 1 1 1 northern blot evidence
YIL082W YIL082W Retrotransposon TYA Gag gene co-transcribed with TYB Pol regulation 1 1 1 DNA to cDNA expression microarray evidence
YGR109W-A YGR109W-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol regulation 1 1 1 DNA to cDNA expression microarray evidence
HUG1 YML058W-A Ribonucleotide reductase inhibitor regulation 1 1 1 DNA to cDNA expression microarray evidence
AQY1 YPR192W Spore-specific water channel regulation 1 1 1 chromatin immunoprecipitation-qPCR evidence
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) regulation 1 1 1 DNA to cDNA expression microarray evidence
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth regulation 1 1 1 northern blot evidence
RPI1 YIL119C Transcription factor, allelic differences between S288C and Sigma1278b regulation 1 1 1 chromatin immunoprecipitation-chip evidence
KAR4 YCL055W Transcription factor required for response to pheromones regulation 1 1 1 DNA to cDNA expression microarray evidence
PRB1 YEL060C Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BTN2 YGR142W v-SNARE binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Dosage Rescue
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Positive Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
MDS3 YGL197W Putative component of the TOR regulatory pathway genetic 1 1 1 Positive Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Positive Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Positive Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 1 1 1 Negative Genetic
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Negative Genetic
LTP1 YPR073C Protein phosphotyrosine phosphatase of unknown cellular role genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Synthetic Lethality
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 PCA
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway physical 1 1 1 Two-hybrid
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ADE6 YGR061C Formylglycinamidine-ribonucleotide (FGAM)-synthetase genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
INO2 YDR123C Transcription factor genetic 1 1 1 Positive Genetic
LPP1 YDR503C Lipid phosphate phosphatase genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex physical 1 1 1 Two-hybrid
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Positive Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Positive Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Negative Genetic
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Negative Genetic
GFD2 YCL036W Protein of unknown function genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
EUC1 YMR111C Sequence-specific DNA binding protein genetic 1 1 1 Negative Genetic
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 1 1 1 Negative Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Lethality
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Positive Genetic
BIO2 YGR286C Biotin synthase physical 1 1 1 Two-hybrid
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 1 1 1 Negative Genetic
ECM22 YLR228C Sterol regulatory element binding protein physical 1 1 1 Affinity Capture-Western
CYC1 YJR048W Cytochrome c, isoform 1 genetic 1 1 1 Positive Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
TMN2 YDR107C Protein with a role in cellular adhesion and filamentous growth physical 1 1 1 Two-hybrid
ROG1 YGL144C Lipase with specificity for monoacylglycerol physical 1 1 1 Two-hybrid
SAY1 YGR263C Sterol deacetylase physical 1 1 1 Two-hybrid
ZEO1 YOL109W Peripheral membrane protein of the plasma membrane physical 1 1 1 Two-hybrid
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Dosage Rescue
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Lethality
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Dosage Rescue
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Dosage Rescue
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Phenotypic Enhancement
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
SVL3 YPL032C Protein of unknown function genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Positive Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Positive Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Positive Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Positive Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
YDR341C YDR341C Arginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
YGR153W YGR153W Putative protein of unknown function genetic 1 1 1 Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
TCD1 YHR003C tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
SFB3 YHR098C Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Negative Genetic
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
YAL037W YAL037W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Negative Genetic
RMD1 YDL001W Cytoplasmic protein required for sporulation genetic 1 1 1 Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Negative Genetic
NDE2 YDL085W Mitochondrial external NADH dehydrogenase genetic 1 1 1 Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Negative Genetic
PEX5 YDR244W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Negative Genetic
MSC3 YLR219W Protein of unknown function genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
ROY1 YMR258C GTPase inhibitor with similarity to F-box proteins genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
YNL165W YNL165W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Positive Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Positive Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Positive Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
SCD6 YPR129W Repressor of translation initiation genetic 1 1 1 Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Positive Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Negative Genetic
CRS5 YOR031W Copper-binding metallothionein genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Negative Genetic
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Positive Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic