Standard name Systematic name Name description Description
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase Membrane-embedded ubiquitin-protein ligase and retrotranslocase; ER and inner nuclear membrane localized RING-CH domain E3 ligase involved in ER-associated protein degradation (ERAD); aids Cdc48p in the extraction of faulty membrane proteins; targets misfolded cytosolic/nucleoplasmic domains of soluble and membrane embedded proteins (ERAD-C) and Sbh2p, a transmembrane domain-containing substrate (ERAD-M); C-terminal element, conserved in human ortholog MARCH6, determines substrate selectivity
Visualize the interactome of SSM4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.238 0.356 0.236
ER 0.501 0.547 0.529
Vac/Vac Memb 0.285 0.062 0.166
Cort. Patches NaN 0.060 NaN
Mito NaN 0.071 0.174
Cell Periphery NaN NaN 0.062

GFP localization & abundance

GFP localization GFP abundance
ER technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SSM4 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
UBC7 YMR022W Ubiquitin conjugating enzyme physical 9 4 7 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 7 2 7 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) physical 6 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 6 2 5 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD physical 5 4 4 Affinity Capture-Western, PCA, Biochemical Activity, Reconstituted Complex, Biochemical Activity
ERG25 YGR060W C-4 methyl sterol oxidase genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 5 3 3 Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 3 2 3 Positive Genetic, Phenotypic Enhancement, Positive Genetic
CUE1 YMR264W Ubiquitin-binding protein physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
STE24 YJR117W Highly conserved zinc metalloprotease genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
UBI4 YLL039C Ubiquitin physical 2 1 2 Biochemical Activity, Biochemical Activity
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 2 1 2 Biochemical Activity, Biochemical Activity
YDR124W YDR124W Mitochondrial protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
ARE2 YNR019W Acyl-CoA:sterol acyltransferase genetic 2 2 1 Phenotypic Enhancement, Synthetic Lethality
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 2 2 1 Phenotypic Enhancement, Synthetic Lethality
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 1 1 Negative Genetic, Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 1 1 Negative Genetic, Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes genetic 2 1 1 Positive Genetic, Positive Genetic
EMA17 YIL029C Protein involved in targeting mitochondrial membrane protein precursor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 2 1 1 Positive Genetic, Positive Genetic
DFM1 YDR411C Endoplasmic reticulum (ER) localized protein physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 1 Positive Genetic, Positive Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
PGC1 YPL206C Phosphatidylglycerol phospholipase C regulation 1 1 1 green fluorescent protein reporter gene assay evidence
SPS2 YDR522C Protein expressed during sporulation regulation 1 1 1 green fluorescent protein reporter gene assay evidence
CSM4 YPL200W Protein required for accurate chromosome segregation during meiosis regulation 1 1 1 green fluorescent protein reporter gene assay evidence
YDL241W YDL241W Putative protein of unknown function regulation 1 1 1 green fluorescent protein reporter gene assay evidence
FMP32 YFL046W Regulator of mitochondrial proline metabolism regulation 1 1 1 green fluorescent protein reporter gene assay evidence
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD regulation 1 1 1 green fluorescent protein reporter gene assay evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Positive Genetic
CDC40 YDR364C Pre-mRNA splicing factor physical 1 1 1 Affinity Capture-Western
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Protein-peptide
NAT3 YPR131C Catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Phenotypic Enhancement
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase physical 1 1 1 Protein-peptide
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA physical 1 1 1 Protein-peptide
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
HIS3 YOR202W Imidazoleglycerol-phosphate dehydratase genetic 1 1 1 Phenotypic Enhancement
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 1 1 1 Protein-peptide
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Protein-peptide
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Protein-peptide
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Synthetic Rescue
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PRO2 YOR323C Gamma-glutamyl phosphate reductase physical 1 1 1 Protein-peptide
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Phenotypic Enhancement
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Rescue
SEC13 YLR208W Structural component of 3 complexes physical 1 1 1 Protein-peptide
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Synthetic Rescue
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Phenotypic Enhancement
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Protein-peptide
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Protein-peptide
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Synthetic Rescue
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
LAP2 YNL045W Leucyl aminopeptidase yscIV with epoxide hydrolase activity physical 1 1 1 Protein-peptide
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis physical 1 1 1 Protein-peptide
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen physical 1 1 1 Protein-peptide
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 1 1 1 Negative Genetic
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Protein-peptide
ADH2 YMR303C Glucose-repressible alcohol dehydrogenase II physical 1 1 1 Protein-peptide
PYC1 YGL062W Pyruvate carboxylase isoform physical 1 1 1 Protein-peptide
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Phenotypic Suppression
GSP1 YLR293C Ran GTPase physical 1 1 1 Protein-peptide
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein physical 1 1 1 Protein-peptide
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Positive Genetic
OYE3 YPL171C Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) physical 1 1 1 Protein-peptide
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism physical 1 1 1 Protein-peptide
PDI1 YCL043C Protein disulfide isomerase physical 1 1 1 Protein-peptide
HSP104 YLL026W Disaggregase physical 1 1 1 Protein-peptide
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
AIP1 YMR092C Actin cortical patch component physical 1 1 1 Protein-peptide
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
PDC5 YLR134W Minor isoform of pyruvate decarboxylase physical 1 1 1 Protein-peptide
ERG20 YJL167W Farnesyl pyrophosphate synthetase physical 1 1 1 Protein-peptide
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
MET6 YER091C Cobalamin-independent methionine synthase genetic 1 1 1 Negative Genetic
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Protein-peptide
CTF4 YPR135W Chromatin-associated protein physical 1 1 1 Protein-peptide
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Phenotypic Enhancement
LYS1 YIR034C Saccharopine dehydrogenase (NAD+, L-lysine-forming) physical 1 1 1 Protein-peptide
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Affinity Capture-Western
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Phenotypic Enhancement
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 1 1 1 Proximity Label-MS
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 Protein-peptide
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
BNA5 YLR231C Kynureninase physical 1 1 1 Protein-peptide
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis physical 1 1 1 Affinity Capture-Western
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Positive Genetic
MVP1 YMR004W Protein required for sorting proteins to the vacuole physical 1 1 1 Protein-peptide
FMP40 YPL222W Mitochondrial AMPylator in the pseudokinase selenoprotein-O family physical 1 1 1 Protein-peptide
CUB1 YPL260W Conserved fungal gene linked to DNA repair and proteasome function genetic 1 1 1 Negative Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Positive Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase physical 1 1 1 Protein-peptide
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO3 YLR372W Elongase genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) physical 1 1 1 Two-hybrid
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-Western
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs genetic 1 1 1 Synthetic Rescue
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Phenotypic Suppression
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Protein-peptide
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Phenotypic Suppression
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 1 1 1 Dosage Growth Defect
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Phenotypic Enhancement
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
CQD1 YPL109C UbiB family mitochondrial protein genetic 1 1 1 Negative Genetic
PBI2 YNL015W Cytosolic inhibitor of vacuolar proteinase B (PRB1) genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
ASN1 YPR145W Asparagine synthetase genetic 1 1 1 Negative Genetic
ABZ1 YNR033W Para-aminobenzoate (PABA) synthase physical 1 1 1 Protein-peptide
MLS1 YNL117W Malate synthase, enzyme of the glyoxylate cycle physical 1 1 1 Protein-peptide
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
HMG1 YML075C HMG-CoA reductase genetic 1 1 1 Dosage Lethality
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
FMO1 YHR176W Flavin-containing monooxygenase genetic 1 1 1 Negative Genetic
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
MET12 YPL023C Protein with MTHFR activity in vitro physical 1 1 1 Protein-peptide
ARA2 YMR041C NAD-dependent arabinose dehydrogenase physical 1 1 1 Protein-peptide
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism physical 1 1 1 Protein-peptide
ADE12 YNL220W Adenylosuccinate synthase physical 1 1 1 Protein-peptide
SOL1 YNR034W Protein with a possible role in tRNA export physical 1 1 1 Protein-peptide
NPT1 YOR209C Nicotinate phosphoribosyltransferase physical 1 1 1 Protein-peptide
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
IDP3 YNL009W Peroxisomal NADP-dependent isocitrate dehydrogenase physical 1 1 1 Protein-peptide
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Negative Genetic
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Protein-peptide
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase physical 1 1 1 Protein-peptide
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Protein-peptide
PAN5 YHR063C 2-dehydropantoate 2-reductase physical 1 1 1 Protein-peptide
ERR2 YPL281C Enolase, a phosphopyruvate hydratase physical 1 1 1 Protein-peptide
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
YJR096W YJR096W Xylose and arabinose reductase physical 1 1 1 Protein-peptide
TDA3 YHR009C Putative oxidoreductase involved in late endosome to Golgi transport physical 1 1 1 Protein-peptide
YCR016W YCR016W Putative protein of unknown function physical 1 1 1 Protein-peptide
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Protein-peptide
THI80 YOR143C Thiamine pyrophosphokinase physical 1 1 1 Protein-peptide
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Protein-peptide
YJL218W YJL218W Mitochondrial protein, putative acetyltransferase physical 1 1 1 Protein-peptide
YIL060W YIL060W Mitochondrial protein of unknown function physical 1 1 1 Protein-peptide
TUM1 YOR251C Rhodanese domain sulfur transferase physical 1 1 1 Protein-peptide
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Protein-peptide
YLR460C YLR460C Member of the quinone oxidoreductase family physical 1 1 1 Protein-peptide
YPT6 YLR262C Rab family GTPase physical 1 1 1 Protein-peptide
TES1 YJR019C Peroxisomal acyl-CoA thioesterase physical 1 1 1 Protein-peptide
YHR112C YHR112C Protein of unknown function physical 1 1 1 Protein-peptide
YGR111W YGR111W Putative protein of unknown function physical 1 1 1 Protein-peptide
STR3 YGL184C Peroxisomal cystathionine beta-lyase physical 1 1 1 Protein-peptide
YGL039W YGL039W Aldehyde reductase physical 1 1 1 Protein-peptide
YER152C YER152C Protein with 2-aminoadipate transaminase activity physical 1 1 1 Protein-peptide
YDL086W YDL086W Putative carboxymethylenebutenolidase physical 1 1 1 Protein-peptide
THR4 YCR053W Threonine synthase physical 1 1 1 Protein-peptide
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Synthetic Rescue
VPH2 YKL119C Integral membrane protein required for V-ATPase function physical 1 1 1 Affinity Capture-Western
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Proximity Label-MS
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Positive Genetic
STP2 YHR006W Transcription factor genetic 1 1 1 Positive Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Phenotypic Enhancement
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p genetic 1 1 1 Phenotypic Enhancement
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Negative Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Positive Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
YPR127W YPR127W Putative pyridoxine 4-dehydrogenase genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
MRX18 YBR056W Putative glycoside hydrolase of the mitochondrial intermembrane space physical 1 1 1 Protein-peptide
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Positive Genetic
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins genetic 1 1 1 Negative Genetic
MSP1 YGR028W Highly-conserved N-terminally anchored AAA-ATPase genetic 1 1 1 Phenotypic Enhancement
SHR5 YOL110W Palmitoyltransferase subunit genetic 1 1 1 Phenotypic Suppression
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
PCA1 YBR295W Cadmium transporting P-type ATPase physical 1 1 1 Affinity Capture-Western
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger physical 1 1 1 PCA
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Positive Genetic
MAL32 YBR299W Maltase (alpha-D-glucosidase) physical 1 1 1 Protein-peptide
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
IMA1 YGR287C Major isomaltase (alpha-1,6-glucosidase/alpha-methylglucosidase) physical 1 1 1 Protein-peptide
POF1 YCL047C Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT) physical 1 1 1 Protein-peptide
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER physical 1 1 1 PCA
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Synthetic Lethality
PDR18 YNR070W Transporter of the ATP-binding cassette (ABC) family physical 1 1 1 PCA
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
SLP1 YOR154W Glycosylated integral ER membrane protein of unknown function genetic 1 1 1 Phenotypic Suppression
MMO1 YKL044W Protein of unknown function genetic 1 1 1 Negative Genetic