Standard name Systematic name Name description Description
SEC4 YFL005W Rab family GTPase Rab family GTPase; essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane; exocyst association is negatively regulated via phosphorylation by Cdc5p during cytokinesis
Visualize the interactome of SEC4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SEC4 2 1 2 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 14 6 11 Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Biochemical Activity, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Co-crystal Structure, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-MS, Two-hybrid
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 12 4 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, PCA, Two-hybrid, Two-hybrid, Affinity Capture-Western
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 9 3 7 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic
GDI1 YER136W GDP dissociation inhibitor physical 8 5 8 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Two-hybrid, PCA, Co-crystal Structure, Two-hybrid, Two-hybrid
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 8 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue
EXO70 YJL085W Subunit of the exocyst complex genetic 8 3 7 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 8 4 6 Dosage Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex physical 8 4 6 Affinity Capture-Western, Two-hybrid, Co-fractionation, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 8 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 8 3 6 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Dosage Rescue
DSS4 YPR017C Guanine nucleotide dissociation stimulator for Sec4p genetic 7 4 6 Dosage Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SEC3 YER008C Subunit of the exocyst complex genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion genetic 7 3 6 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SRO7 YPR032W Effector of Rab GTPase Sec4p physical 7 3 4 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 6 4 6 Synthetic Growth Defect, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
SMY1 YKL079W Kinesin-like myosin passenger-protein genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Rescue
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 6 3 4 Synthetic Lethality, Synthetic Lethality, Dosage Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 6 3 4 Dosage Rescue, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic
MSO1 YNR049C Lipid-interacting protein in SNARE complex assembly machinery genetic 5 3 5 Synthetic Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic
DSS4 YPR017C Guanine nucleotide dissociation stimulator for Sec4p physical 5 3 3 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Two-hybrid
MRS6 YOR370C Rab escort protein physical 4 3 4 Affinity Capture-Western, PCA, PCA, Affinity Capture-MS
CDC42 YLR229C Small rho-like GTPase genetic 4 2 3 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly genetic 4 2 3 Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue
GDI1 YER136W GDP dissociation inhibitor genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 3 2 3 Dosage Growth Defect, Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 3 2 3 Phenotypic Suppression, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MSB3 YNL293W Rab GTPase-activating protein physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
MSO1 YNR049C Lipid-interacting protein in SNARE complex assembly machinery physical 3 3 2 Affinity Capture-Western, PCA, Reconstituted Complex
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
MRS6 YOR370C Rab escort protein genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
YIF1 YNL263C Integral membrane protein physical 3 2 2 Reconstituted Complex, Two-hybrid, Two-hybrid
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SEC9 YGR009C t-SNARE protein required for secretory vesicle-plasma membrane fusion physical 2 2 2 Affinity Capture-Western, PCA
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 2 2 2 Dosage Growth Defect, Negative Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 2 2 2 Synthetic Lethality, Dosage Rescue
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 2 2 2 Negative Genetic, Phenotypic Suppression
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 1 2 Negative Genetic, Negative Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 2 1 2 Negative Genetic, Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 2 1 2 Negative Genetic, Negative Genetic
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 2 1 2 Negative Genetic, Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 2 1 2 Negative Genetic, Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 1 2 Negative Genetic, Negative Genetic
MDR1 YGR100W Cytoplasmic GTPase-activating protein physical 2 1 2 Biochemical Activity, Biochemical Activity
ERG25 YGR060W C-4 methyl sterol oxidase genetic 2 1 2 Negative Genetic, Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 2 1 2 Negative Genetic, Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 2 2 1 Affinity Capture-MS, Two-hybrid
LAS17 YOR181W Actin assembly factor physical 2 2 1 Reconstituted Complex, PCA
YIP3 YNL044W Protein localized to COPII vesicles physical 2 2 1 Affinity Capture-Western, Two-hybrid
IRC6 YFR043C Clathrin coat accessory factor physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
GWT1 YJL091C Protein involved in the inositol acylation of GlcN-PI genetic 2 1 1 Negative Genetic, Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 2 1 1 Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 2 1 1 Negative Genetic, Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 1 Negative Genetic, Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 1 1 Negative Genetic, Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 1 Negative Genetic, Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Negative Genetic, Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 2 1 1 Negative Genetic, Negative Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
PFY1 YOR122C Profilin genetic 2 1 1 Negative Genetic, Negative Genetic
GUK1 YDR454C Guanylate kinase genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Synthetic Rescue
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase physical 1 1 1 Co-fractionation
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Dosage Growth Defect
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
PTA1 YAL043C Subunit of holo-CPF genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I physical 1 1 1 Affinity Capture-MS
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Dosage Rescue
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Synthetic Lethality
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Dosage Growth Defect
BOI2 YER114C Protein involved in polar growth physical 1 1 1 Two-hybrid
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Lethality
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain genetic 1 1 1 Phenotypic Suppression
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Phenotypic Suppression
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
ACK1 YDL203C Protein that functions in the cell wall integrity pathway genetic 1 1 1 Positive Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 Affinity Capture-Western
ATG18 YFR021W Phosphoinositide binding protein physical 1 1 1 Affinity Capture-MS
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Negative Genetic
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC physical 1 1 1 Affinity Capture-MS
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SEC13 YLR208W Structural component of 3 complexes physical 1 1 1 Affinity Capture-MS
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
CRN1 YLR429W Coronin genetic 1 1 1 Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
ATG9 YDL149W Transmembrane protein involved in forming Cvt and autophagic vesicles physical 1 1 1 Affinity Capture-MS
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Negative Genetic
SEC3 YER008C Subunit of the exocyst complex physical 1 1 1 Affinity Capture-Western
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p physical 1 1 1 PCA
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 1 1 1 Biochemical Activity
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
KIN1 YDR122W S/T protein kinase genetic 1 1 1 Dosage Rescue
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Positive Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Growth Defect
KIN2 YLR096W S/T protein kinase genetic 1 1 1 Dosage Rescue
YPT1 YFL038C Rab family GTPase physical 1 1 1 Affinity Capture-MS
YOP1 YPR028W Reticulon-interacting protein physical 1 1 1 Affinity Capture-Western
YIP4 YGL198W Protein that interacts with Rab GTPases physical 1 1 1 Reconstituted Complex
YIP1 YGR172C Integral membrane protein physical 1 1 1 Two-hybrid
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Synthetic Lethality
SED5 YLR026C cis-Golgi t-SNARE syntaxin physical 1 1 1 Co-purification
TLG2 YOL018C Syntaxin-like t-SNARE physical 1 1 1 Co-purification
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 1 1 1 Affinity Capture-RNA
VPS16 YPL045W Subunit of the HOPS and the CORVET complexes physical 1 1 1 Two-hybrid
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) physical 1 1 1 Affinity Capture-Western
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 1 1 1 Affinity Capture-MS
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting physical 1 1 1 Affinity Capture-MS
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 PCA
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 Affinity Capture-MS
SMY1 YKL079W Kinesin-like myosin passenger-protein physical 1 1 1 Affinity Capture-Western
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 1 1 1 Dosage Rescue
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p genetic 1 1 1 Dosage Rescue
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Phenotypic Enhancement
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
YPT31 YER031C Rab family GTPase genetic 1 1 1 Negative Genetic
SSO1 YPL232W Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 1 1 1 Negative Genetic
YAP1802 YGR241C Protein of the AP180 family, involved in clathrin cage assembly genetic 1 1 1 Phenotypic Suppression
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Synthetic Growth Defect
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
UTR5 YEL035C Protein of unknown function genetic 1 1 1 Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 1 1 1 Negative Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
YKL162C YKL162C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
YBR221W-A YBR221W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Negative Genetic
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
YIL134C-A YIL134C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Phenotypic Enhancement
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
GBP2 YCL011C Poly(A+) RNA-binding protein genetic 1 1 1 Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
ATG1 YGL180W Protein serine/threonine kinase physical 1 1 1 Affinity Capture-MS
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Phenotypic Enhancement
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
LDB17 YDL146W Protein involved in the regulation of endocytosis genetic 1 1 1 Phenotypic Suppression
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Growth Defect
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Negative Genetic
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
ATG23 YLR431C Peripheral membrane protein required for autophagy and CVT physical 1 1 1 Affinity Capture-MS
ATG8 YBL078C Ub-like protein physical 1 1 1 Affinity Capture-MS
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Phenotypic Suppression
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) physical 1 1 1 Affinity Capture-Western
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
CCP1 YKR066C Mitochondrial cytochrome-c peroxidase genetic 1 1 1 Phenotypic Suppression
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs physical 1 1 1 Biochemical Activity
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein physical 1 1 1 PCA
PEX11 YOL147C Peroxisomal protein required for medium-chain fatty acid oxidation physical 1 1 1 PCA
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p physical 1 1 1 Affinity Capture-Western
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 1 1 1 PCA
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 1 1 1 Affinity Capture-MS
ARK1 YNL020C Ser/Thr protein kinase genetic 1 1 1 Negative Genetic
MSB3 YNL293W Rab GTPase-activating protein genetic 1 1 1 Dosage Rescue
MSB4 YOL112W GTPase-activating protein of the Ras superfamily physical 1 1 1 Biochemical Activity
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Positive Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
IDS2 YJL146W Protein involved in modulation of Ime2p activity during meiosis genetic 1 1 1 Negative Genetic
EPO1 YMR124W Protein involved in septin-ER tethering physical 1 1 1 PCA
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Affinity Capture-MS
GDA1 YEL042W Guanosine diphosphatase located in the Golgi genetic 1 1 1 Negative Genetic
BPL1 YDL141W Biotin:apoprotein ligase physical 1 1 1 Affinity Capture-MS
BPH1 YCR032W Protein homologous to Chediak-Higashi syndrome and Beige proteins genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Dosage Rescue
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
OPY2 YPR075C Integral membrane protein that acts as a membrane anchor for Ste50p genetic 1 1 1 Negative Genetic
ORM1 YGR038W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
OSH7 YHR001W Oxysterol-binding phosphatidylserine transferase genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
MNN2 YBR015C Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase physical 1 1 1 PCA
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 PCA
MAM1 YER106W Monopolin genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Positive Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
GYP8 YFL027C GTPase-activating protein for yeast Rab family members physical 1 1 1 Biochemical Activity
HMI1 YOL095C Mitochondrial inner membrane localized ATP-dependent DNA helicase genetic 1 1 1 Negative Genetic