Standard name Systematic name Name description Description
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains SIR protein involved in assembly of silent chromatin domains; silent information regulator (SIR) along with SIR2 and SIR3; involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; some SIR4 alleles prolong lifespan; required for Ku-mediated telomerase recruitment, telomere lengthening, and telomere hypercluster formation in quiescent yeast cells
Visualize the interactome of SIR4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 91

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.066 0.078 0.090
Endosome 0.500 0.300 0.090
Nuc Periphery 0.082 NaN NaN
Nucleolus 0.082 NaN NaN
Nucleus 0.135 0.171 0.108
SpindlePole 0.253 0.081 0.225
Vac/Vac Memb 0.184 0.282 NaN
Mito NaN 0.275 0.514

GFP localization & abundance

GFP localization GFP abundance
nuclear periphery technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SIR4 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 34 6 27 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Reconstituted Complex, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Co-purification, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
SIR3 YLR442C Silencing protein physical 30 7 24 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Co-localization, Two-hybrid, Co-localization, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Co-localization, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Co-purification, Affinity Capture-Western, Far Western, Reconstituted Complex
ESC1 YMR219W Protein involved in telomeric silencing physical 9 5 6 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Affinity Capture-MS
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 8 3 7 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR physical 7 2 6 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 7 4 5 Two-hybrid, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 7 4 5 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 6 3 5 Two-hybrid, Two-hybrid, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Two-hybrid
HHF1 YBR009C Histone H4 physical 5 3 5 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Biochemical Activity, Reconstituted Complex
SIR3 YLR442C Silencing protein genetic 5 3 5 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) physical 5 2 4 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
SAN1 YDR143C Ubiquitin-protein ligase genetic 4 3 3 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement
HHT1 YBR010W Histone H3 physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 3 2 3 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
NUP157 YER105C Subunit of the inner ring of the nuclear pore complex (NPC) physical 3 2 3 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
RAD53 YPL153C DNA damage response kinase genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 3 3 2 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
SAN1 YDR143C Ubiquitin-protein ligase physical 3 2 2 Two-hybrid, Affinity Capture-MS, Two-hybrid
MPS3 YJL019W Nuclear envelope protein physical 3 2 2 Affinity Capture-Western, Two-hybrid, Two-hybrid
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 3 1 2 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) physical 3 1 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 2 2 2 Affinity Capture-Western, Biochemical Activity
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth physical 2 2 2 Two-hybrid, Reconstituted Complex
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 2 2 1 Dosage Rescue, Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 2 2 1 Two-hybrid, Reconstituted Complex
GSP1 YLR293C Ran GTPase physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 2 2 1 Affinity Capture-MS, Reconstituted Complex
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 2 2 1 Affinity Capture-Western, Co-localization
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein physical 2 2 1 Affinity Capture-MS, Reconstituted Complex
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RTT106 YNL206C Histone chaperone physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HTB1 YDR224C Histone H2B genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase regulation 1 1 1 RNA-sequencing evidence
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase regulation 1 1 1 RNA-sequencing evidence
SER1 YOR184W 3-phosphoserine aminotransferase regulation 1 1 1 RNA-sequencing evidence
ADI1 YMR009W Acireductone dioxygenease involved in methionine salvage pathway regulation 1 1 1 RNA-sequencing evidence
MET14 YKL001C Adenylylsulfate kinase regulation 1 1 1 RNA-sequencing evidence
AGA2 YGL032C Adhesion subunit of a-agglutinin of a-cells regulation 1 1 1 RNA-sequencing evidence
YPC1 YBR183W Alkaline ceramidase regulation 1 1 1 RNA-sequencing evidence
CAR1 YPL111W Arginase, catabolizes arginine to ornithine and urea regulation 1 1 1 RNA-sequencing evidence
ARO9 YHR137W Aromatic aminotransferase II regulation 1 1 1 RNA-sequencing evidence
BAR1 YIL015W Aspartyl protease secreted to periplasmic space of mating type a cell regulation 1 1 1 RNA-sequencing evidence
MET3 YJR010W ATP sulfurylase regulation 1 1 1 RNA-sequencing evidence
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase regulation 1 1 1 RNA-sequencing evidence
SUN4 YNL066W Cell wall protein related to glucanases localized in birth scars regulation 1 1 1 RNA-sequencing evidence
MHF2 YDL160C-A Component of the heterotetrameric MHF histone-fold complex regulation 1 1 1 RNA-sequencing evidence
TOS1 YBR162C Covalently-bound cell wall protein of unknown function regulation 1 1 1 RNA-sequencing evidence
CYB5 YNL111C Cytochrome b5 regulation 1 1 1 RNA-sequencing evidence
CYT1 YOR065W Cytochrome c1 regulation 1 1 1 RNA-sequencing evidence
CYC1 YJR048W Cytochrome c, isoform 1 regulation 1 1 1 RNA-sequencing evidence
CYC7 YEL039C Cytochrome c isoform 2, expressed under hypoxic conditions regulation 1 1 1 RNA-sequencing evidence
COA2 YPL189C-A Cytochrome oxidase assembly factor regulation 1 1 1 RNA-sequencing evidence
HUA2 YOR284W Cytoplasmic protein of unknown function regulation 1 1 1 RNA-sequencing evidence
ERG6 YML008C Delta(24)-sterol C-methyltransferase regulation 1 1 1 RNA-sequencing evidence
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis regulation 1 1 1 RNA-sequencing evidence
RDH54 YBR073W DNA-dependent ATPase regulation 1 1 1 RNA-sequencing evidence
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) regulation 1 1 1 RNA-sequencing evidence
YNL337W YNL337W Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
YCL076W YCL076W Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
YFL063W YFL063W Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
YCR097W-A YCR097W-A Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
YCL065W YCL065W Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
YGR182C YGR182C Dubious open reading frame regulation 1 1 1 RNA-sequencing evidence
COS1 YNL336W Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 RNA-sequencing evidence
COS4 YFL062W Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 RNA-sequencing evidence
COS6 YGR295C Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 RNA-sequencing evidence
COS8 YHL048W Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 RNA-sequencing evidence
COS7 YDL248W Endosomal protein involved in turnover of plasma membrane proteins regulation 1 1 1 RNA-sequencing evidence
YNR064C YNR064C Epoxide hydrolase regulation 1 1 1 RNA-sequencing evidence
HMX1 YLR205C ER localized heme oxygenase regulation 1 1 1 RNA-sequencing evidence
STE14 YDR410C Farnesyl cysteine-carboxyl methyltransferase regulation 1 1 1 RNA-sequencing evidence
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle regulation 1 1 1 RNA-sequencing evidence
STE4 YOR212W G protein beta subunit regulation 1 1 1 RNA-sequencing evidence
STE18 YJR086W G protein gamma subunit regulation 1 1 1 RNA-sequencing evidence
SST2 YLR452C GTPase-activating protein for Gpa1p regulation 1 1 1 RNA-sequencing evidence
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone regulation 1 1 1 RNA-sequencing evidence
YGL193C YGL193C Haploid-specific gene repressed by a1-alpha2 regulation 1 1 1 RNA-sequencing evidence
HPF1 YOL155C Haze-protective mannoprotein regulation 1 1 1 RNA-sequencing evidence
ROX1 YPR065W Heme-dependent repressor of hypoxic genes regulation 1 1 1 RNA-sequencing evidence
MMP1 YLL061W High-affinity S-methylmethionine permease regulation 1 1 1 RNA-sequencing evidence
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane regulation 1 1 1 RNA-sequencing evidence
MPC3 YGR243W Highly conserved subunit of the mitochondrial pyruvate carrier (MPC) regulation 1 1 1 RNA-sequencing evidence
IMD2 YHR216W Inosine monophosphate dehydrogenase regulation 1 1 1 RNA-sequencing evidence
AXL2 YIL140W Integral plasma membrane protein regulation 1 1 1 RNA-sequencing evidence
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase regulation 1 1 1 RNA-sequencing evidence
BNA5 YLR231C Kynureninase regulation 1 1 1 RNA-sequencing evidence
BNA4 YBL098W Kynurenine 3-monooxygenase regulation 1 1 1 RNA-sequencing evidence
DLD1 YDL174C Major mitochondrial D-lactate dehydrogenase regulation 1 1 1 RNA-sequencing evidence
MFA2 YNL145W Mating pheromone a-factor regulation 1 1 1 RNA-sequencing evidence
MFA1 YDR461W Mating pheromone a-factor regulation 1 1 1 RNA-sequencing evidence
YLR460C YLR460C Member of the quinone oxidoreductase family regulation 1 1 1 RNA-sequencing evidence
PAU4 YLR461W Member of the seripauperin multigene family regulation 1 1 1 RNA-sequencing evidence
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate regulation 1 1 1 RNA-sequencing evidence
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase regulation 1 1 1 RNA-sequencing evidence
NDE1 YMR145C Mitochondrial external NADH dehydrogenase regulation 1 1 1 RNA-sequencing evidence
CRC1 YOR100C Mitochondrial inner membrane carnitine transporter regulation 1 1 1 RNA-sequencing evidence
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase regulation 1 1 1 RNA-sequencing evidence
PRX1 YBL064C Mitochondrial peroxiredoxin with thioredoxin peroxidase activity regulation 1 1 1 RNA-sequencing evidence
SFC1 YJR095W Mitochondrial succinate-fumarate transporter regulation 1 1 1 RNA-sequencing evidence
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating regulation 1 1 1 RNA-sequencing evidence
AMN1 YBR158W Modulator of cell separation and mitotic exit regulation 1 1 1 RNA-sequencing evidence
IME4 YGL192W mRNA N6-adenosine methyltransferase regulation 1 1 1 RNA-sequencing evidence
DDR2 YOL052C-A Multi-stress response protein regulation 1 1 1 RNA-sequencing evidence
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase regulation 1 1 1 RNA-sequencing evidence
ADH7 YCR105W NADPH-dependent medium chain alcohol dehydrogenase regulation 1 1 1 RNA-sequencing evidence
MTH1 YDR277C Negative regulator of the glucose-sensing signal transduction pathway regulation 1 1 1 RNA-sequencing evidence
YAR075W YAR075W Non-functional protein with homology IMP dehydrogenase regulation 1 1 1 RNA-sequencing evidence
IMD1 YAR073W Nonfunctional protein with homology to IMP dehydrogenase regulation 1 1 1 RNA-sequencing evidence
GTO3 YMR251W Omega class glutathione transferase regulation 1 1 1 RNA-sequencing evidence
PLN1 YKR046C Perilipin, involved in formation and stability of lipid droplets regulation 1 1 1 RNA-sequencing evidence
VBA2 YBR293W Permease of basic amino acids in the vacuolar membrane regulation 1 1 1 RNA-sequencing evidence
VBA3 YCL069W Permease of basic amino acids in the vacuolar membrane regulation 1 1 1 RNA-sequencing evidence
STE5 YDR103W Pheromone-responsive MAPK scaffold protein regulation 1 1 1 RNA-sequencing evidence
ERG8 YMR220W Phosphomevalonate kinase regulation 1 1 1 RNA-sequencing evidence
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter regulation 1 1 1 RNA-sequencing evidence
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization regulation 1 1 1 RNA-sequencing evidence
JID1 YPR061C Probable Hsp40p co-chaperone regulation 1 1 1 RNA-sequencing evidence
YDR018C YDR018C Probable membrane protein with three predicted transmembrane domains regulation 1 1 1 RNA-sequencing evidence
PUT4 YOR348C Proline permease regulation 1 1 1 RNA-sequencing evidence
NCA3 YJL116C Protein involved in mitochondrion organization regulation 1 1 1 RNA-sequencing evidence
NSG2 YNL156C Protein involved in regulation of sterol biosynthesis regulation 1 1 1 RNA-sequencing evidence
THI5 YFL058W Protein involved in synthesis of the thiamine precursor HMP regulation 1 1 1 RNA-sequencing evidence
YER053C-A YER053C-A Protein of unknown function regulation 1 1 1 RNA-sequencing evidence
SNO3 YFL060C Protein of unknown function regulation 1 1 1 RNA-sequencing evidence
ICS2 YBR157C Protein of unknown function regulation 1 1 1 RNA-sequencing evidence
ICY1 YMR195W Protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YKR075C YKR075C Protein of unknown function regulation 1 1 1 RNA-sequencing evidence
CMC4 YMR194C-B Protein that localizes to the mitochondrial intermembrane space regulation 1 1 1 RNA-sequencing evidence
YPS5 YGL259W Protein with similarity to GPI-anchored aspartic proteases regulation 1 1 1 RNA-sequencing evidence
GEX1 YCL073C Proton:glutathione antiporter regulation 1 1 1 RNA-sequencing evidence
PDH1 YPR002W Putative 2-methylcitrate dehydratase regulation 1 1 1 RNA-sequencing evidence
AAD15 YOL165C Putative aryl-alcohol dehydrogenase regulation 1 1 1 RNA-sequencing evidence
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein regulation 1 1 1 RNA-sequencing evidence
DPI8 YJL133C-A Putative mitochondrial protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YJL047C-A YJL047C-A Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YCL068C YCL068C Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YFR057W YFR057W Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YGL258W-A YGL258W-A Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YIL014C-A YIL014C-A Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YDR042C YDR042C Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YMR206W YMR206W Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YPR027C YPR027C Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
YJR115W YJR115W Putative protein of unknown function regulation 1 1 1 RNA-sequencing evidence
STE2 YFL026W Receptor for alpha-factor pheromone regulation 1 1 1 RNA-sequencing evidence
YDR034C-D YDR034C-D Retrotransposon TYA Gag and TYB Pol genes regulation 1 1 1 RNA-sequencing evidence
YDR170W-A YDR170W-A Retrotransposon TYA Gag gene regulation 1 1 1 RNA-sequencing evidence
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly regulation 1 1 1 RNA-sequencing evidence
REX3 YLR107W RNA exonuclease regulation 1 1 1 RNA-sequencing evidence
HMRA1 YCR097W Silenced copy of a1 at HMR regulation 1 1 1 RNA-sequencing evidence
HMRA2 YCR096C Silenced copy of a2 at HMR regulation 1 1 1 RNA-sequencing evidence
HMLALPHA1 YCL066W Silenced copy of ALPHA1 at HML regulation 1 1 1 RNA-sequencing evidence
HMLALPHA2 YCL067C Silenced copy of ALPHA2 at HML regulation 1 1 1 RNA-sequencing evidence
HO YDL227C Site-specific endonuclease regulation 1 1 1 RNA-sequencing evidence
RSB1 YOR049C Sphingoid long-chain base (LCB) efflux transporter regulation 1 1 1 RNA-sequencing evidence
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) regulation 1 1 1 RNA-sequencing evidence
QCR6 YFR033C Subunit 6 of the ubiquinol cytochrome-c reductase complex regulation 1 1 1 RNA-sequencing evidence
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) regulation 1 1 1 RNA-sequencing evidence
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) regulation 1 1 1 RNA-sequencing evidence
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) regulation 1 1 1 RNA-sequencing evidence
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase regulation 1 1 1 RNA-sequencing evidence
COX26 YDR119W-A Subunit of cytochrome C oxidase complex regulation 1 1 1 RNA-sequencing evidence
GPA1 YHR005C Subunit of G protein involved in pheromone response regulation 1 1 1 RNA-sequencing evidence
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase regulation 1 1 1 RNA-sequencing evidence
QCR10 YHR001W-A Subunit of the ubiqunol-cytochrome c oxidoreductase complex regulation 1 1 1 RNA-sequencing evidence
COX5A YNL052W Subunit Va of cytochrome c oxidase regulation 1 1 1 RNA-sequencing evidence
COX7 YMR256C Subunit VII of cytochrome c oxidase (Complex IV) regulation 1 1 1 RNA-sequencing evidence
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) regulation 1 1 1 RNA-sequencing evidence
AHP1 YLR109W Thiol-specific peroxiredoxin regulation 1 1 1 RNA-sequencing evidence
HAP4 YKL109W Transcription factor regulation 1 1 1 RNA-sequencing evidence
ATG39 YLR312C Transmembrane receptor with a role in nucleophagy regulation 1 1 1 RNA-sequencing evidence
TGL2 YDR058C Triacylglycerol lipase that is localized to the mitochondria regulation 1 1 1 RNA-sequencing evidence
BNA2 YJR078W Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase regulation 1 1 1 RNA-sequencing evidence
UBX6 YJL048C UBX (ubiquitin regulatory X) domain-containing protein regulation 1 1 1 RNA-sequencing evidence
RME1 YGR044C Zinc finger protein involved in control of meiosis regulation 1 1 1 RNA-sequencing evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Phenotypic Enhancement
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Two-hybrid
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs physical 1 1 1 Two-hybrid
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Phenotypic Suppression
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
NSE3 YDR288W Component of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly physical 1 1 1 Two-hybrid
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p physical 1 1 1 Two-hybrid
LSM6 YDR378C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Two-hybrid
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
HST1 YOL068C NAD(+)-dependent histone deacetylase physical 1 1 1 Affinity Capture-Western
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 1 1 1 Phenotypic Suppression
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Two-hybrid
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Phenotypic Enhancement
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-Western
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Reconstituted Complex
BLM10 YFL007W Proteasome activator physical 1 1 1 Affinity Capture-MS
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-Western
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Phenotypic Enhancement
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Rescue
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes physical 1 1 1 Affinity Capture-Western
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-Western
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Two-hybrid
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Rescue
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Growth Defect
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-Western
GSP1 YLR293C Ran GTPase genetic 1 1 1 Synthetic Growth Defect
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
ACS2 YLR153C Acetyl-coA synthetase isoform physical 1 1 1 Affinity Capture-MS
ETP1 YHL010C Protein of unknown function required for growth on ethanol physical 1 1 1 Two-hybrid
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Rescue
DIA2 YOR080W Origin-binding F-box protein physical 1 1 1 Biochemical Activity
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Synthetic Rescue
CHZ1 YER030W Histone chaperone for Htz1p/H2A-H2B dimer physical 1 1 1 Co-localization
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-Western
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-Western
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Phenotypic Suppression
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Two-hybrid
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Phenotypic Suppression
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 1 1 1 Two-hybrid
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Phenotypic Enhancement
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
YLR278C YLR278C Zinc-cluster protein physical 1 1 1 Affinity Capture-MS
VPS71 YML041C Nucleosome-binding component of the SWR1 complex physical 1 1 1 Affinity Capture-MS
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes physical 1 1 1 Two-hybrid
SRC1 YML034W Inner nuclear membrane protein physical 1 1 1 Affinity Capture-Western
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-Western
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 1 1 1 Two-hybrid
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm physical 1 1 1 Affinity Capture-MS
YRB2 YIL063C Protein of unknown function physical 1 1 1 Affinity Capture-MS
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Rescue
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Phenotypic Suppression
YCR041W YCR041W Protein of unknown function genetic 1 1 1 Phenotypic Suppression
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Rescue
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation physical 1 1 1 Two-hybrid
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Synthetic Rescue
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Phenotypic Enhancement
NMA2 YGR010W Nicotinic acid mononucleotide adenylyltransferase physical 1 1 1 Two-hybrid
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Dosage Rescue
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Affinity Capture-Western
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Synthetic Growth Defect
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping physical 1 1 1 Affinity Capture-MS
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
KAR3 YPR141C Minus-end-directed microtubule motor physical 1 1 1 Two-hybrid
SAS2 YMR127C Histone acetyltransferase (HAT) catalytic subunit of the SAS complex genetic 1 1 1 Synthetic Rescue
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Synthetic Rescue
GAL4 YPL248C DNA-binding transcription factor required for activating GAL genes physical 1 1 1 PCA
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Synthetic Rescue
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Phenotypic Suppression
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p physical 1 1 1 Two-hybrid
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-Western
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-Western
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Two-hybrid
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Rescue
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex physical 1 1 1 Affinity Capture-Western
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family physical 1 1 1 Affinity Capture-MS
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Phenotypic Suppression
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Synthetic Rescue
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-Western
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 1 1 1 Two-hybrid
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Dosage Rescue
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Two-hybrid
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Phenotypic Enhancement
ARR1 YPR199C Transcriptional activator of the basic leucine zipper (bZIP) family physical 1 1 1 Two-hybrid
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Phenotypic Suppression