| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
15 |
4 |
13 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
physical |
14 |
6 |
11 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, PCA |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
12 |
1 |
12 |
Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
9 |
5 |
8 |
Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Positive Genetic |
| ESP1 |
YGR098C |
Separase/separin, a caspase-like cysteine protease |
genetic |
7 |
6 |
5 |
Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect |
| SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
5 |
4 |
4 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic |
| CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
5 |
3 |
4 |
Phenotypic Enhancement, Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
5 |
3 |
4 |
Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
5 |
2 |
4 |
Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| CHK1 |
YBR274W |
Serine/threonine kinase and DNA damage checkpoint effector |
physical |
5 |
2 |
3 |
Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
4 |
4 |
4 |
Dosage Lethality, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
4 |
3 |
4 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
| SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
4 |
4 |
3 |
Phenotypic Suppression, Phenotypic Enhancement, Dosage Growth Defect, Synthetic Rescue |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
4 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Dosage Growth Defect |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
3 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
3 |
2 |
3 |
Negative Genetic, Negative Genetic, Phenotypic Suppression |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
3 |
2 |
2 |
Phenotypic Suppression, Negative Genetic, Negative Genetic |
| SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| RRM3 |
YHR031C |
DNA helicase involved in rDNA replication and Ty1 transposition |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| YDJ1 |
YNL064C |
Type I HSP40 co-chaperone |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SGT1 |
YOR057W |
Cochaperone protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
3 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
| NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| APC2 |
YLR127C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Synthetic Lethality |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Lethality |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Enhancement |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YBP2 |
YGL060W |
Central kinetochore associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DDI1 |
YER143W |
Aspartic-type endopeptidase |
genetic |
2 |
1 |
2 |
Dosage Rescue, Dosage Rescue |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| EPS1 |
YIL005W |
ER protein with chaperone and co-chaperone activity |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
| ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
| UGA3 |
YDL170W |
Transcriptional activator for GABA-dependent induction of GABA genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SWI6 |
YLR182W |
Transcription cofactor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF5 |
YLR175W |
Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP123 |
YER110C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC16 |
YKL022C |
Subunit of the anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
physical |
1 |
1 |
1 |
Two-hybrid |
| CMK1 |
YFR014C |
Calmodulin-dependent protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PDS1 |
YDR113C |
Securin |
physical |
1 |
1 |
1 |
Protein-peptide |
| SWI3 |
YJL176C |
Subunit of the SWI/SNF chromatin remodeling complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PTK2 |
YJR059W |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SNF1 |
YDR477W |
AMP-activated S/T protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TPK1 |
YJL164C |
cAMP-dependent protein kinase catalytic subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP12 |
YJL197W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP10 |
YNL186W |
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP3 |
YER151C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP2 |
YOR124C |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP1 |
YDL122W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP6 |
YFR010W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP14 |
YBR058C |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP8 |
YMR223W |
Ubiquitin-specific protease component of the SAGA acetylation complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP13 |
YBL067C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBI4 |
YLL039C |
Ubiquitin |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RAD23 |
YEL037C |
Protein with ubiquitin-like N terminus |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RAD24 |
YER173W |
Checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RED1 |
YLR263W |
Protein component of the synaptonemal complex axial elements |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YMR317W |
YMR317W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| QRI5 |
YLR204W |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SWS2 |
YNL081C |
Putative mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| VPS64 |
YDR200C |
Protein required for cytoplasm to vacuole targeting of proteins |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YLR154C-H |
YLR154C-H |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC97 |
YHR172W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRE10 |
YOR362C |
Alpha 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC29 |
YPL124W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS29A |
YLR388W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIO1 |
YOR119C |
Serine kinase involved in cell cycle regulation and rDNA integrity |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YEL1 |
YBL060W |
Guanine nucleotide exchange factor specific for Arf3p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNH1 |
YMR234W |
Ribonuclease H1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RNH202 |
YDR279W |
Ribonuclease H2 subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG1 |
YGL180W |
Protein serine/threonine kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENT3 |
YJR125C |
Protein containing an N-terminal epsin-like domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRE1 |
YHR079C |
Serine-threonine kinase and endoribonuclease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC27 |
YBL084C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DAL81 |
YIR023W |
Positive regulator of genes in multiple nitrogen degradation pathways |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCM1 |
YMR043W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EPS1 |
YIL005W |
ER protein with chaperone and co-chaperone activity |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUD2 |
YKL074C |
Protein involved in early pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OTU1 |
YFL044C |
Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCC1 |
YLR220W |
Vacuolar Fe2+/Mn2+ transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSS1 |
YMR023C |
Mitochondrial protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AZR1 |
YGR224W |
Plasma membrane transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PCH2 |
YBR186W |
Hexameric ring ATPase that remodels chromosome axis protein Hop1p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLB6 |
YGR109C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPI34 |
YOR114W |
Putative mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSH1 |
YHR120W |
DNA-binding protein of the mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
