| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
physical |
20 |
6 |
16 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Co-purification, Co-fractionation, Co-fractionation, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Co-purification |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
11 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
11 |
4 |
8 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic |
| RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
10 |
4 |
8 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality |
| MRC1 |
YCL061C |
S-phase checkpoint protein required for DNA replication |
genetic |
10 |
4 |
7 |
Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
genetic |
9 |
2 |
8 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
8 |
2 |
6 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| POL3 |
YDL102W |
Catalytic subunit of DNA polymerase delta |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
7 |
2 |
6 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| PCH2 |
YBR186W |
Hexameric ring ATPase that remodels chromosome axis protein Hop1p |
genetic |
7 |
4 |
5 |
Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
physical |
7 |
3 |
5 |
Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Co-fractionation, Two-hybrid, Two-hybrid, Affinity Capture-Western |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
6 |
2 |
6 |
Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
6 |
3 |
5 |
Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
6 |
3 |
5 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
6 |
2 |
5 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
6 |
2 |
4 |
Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
6 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DMC1 |
YER179W |
Meiosis-specific recombinase required for double-strand break repair |
genetic |
5 |
3 |
5 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
5 |
3 |
4 |
Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Positive Genetic, Positive Genetic |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
4 |
3 |
4 |
Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| TEL1 |
YBL088C |
Protein kinase primarily involved in telomere length regulation |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect |
| CDC6 |
YJL194W |
Essential ATP-binding protein required for DNA replication |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| MCM2 |
YBL023C |
Protein involved in DNA replication |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| REV3 |
YPL167C |
Catalytic subunit of DNA polymerase zeta |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression |
| ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
3 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement |
| RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MCM7 |
YBR202W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PRI2 |
YKL045W |
Subunit of DNA primase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CDC8 |
YJR057W |
Nucleoside monophosphate and nucleoside diphosphate kinase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| POL1 |
YNL102W |
Catalytic subunit of the DNA polymerase I alpha-primase complex |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| PPH3 |
YDR075W |
Catalytic subunit of protein phosphatase PP4 complex |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| DDC1 |
YPL194W |
DNA damage checkpoint protein |
genetic |
2 |
2 |
2 |
Dosage Rescue, Dosage Growth Defect |
| APN1 |
YKL114C |
Major apurinic/apyrimidinic endonuclease |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
2 |
2 |
2 |
Positive Genetic, Synthetic Growth Defect |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Enhancement |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| POL30 |
YBR088C |
Proliferating cell nuclear antigen (PCNA) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DCD1 |
YHR144C |
Deoxycytidine monophosphate (dCMP) deaminase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NDT80 |
YHR124W |
Meiosis-specific transcription factor |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| HST4 |
YDR191W |
NAD(+)-dependent protein deacetylase |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| RAD17 |
YOR368W |
Checkpoint protein |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
| RTT106 |
YNL206C |
Histone chaperone |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Suppression |
| CSM4 |
YPL200W |
Protein required for accurate chromosome segregation during meiosis |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Growth Defect |
| PSF2 |
YJL072C |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SLD5 |
YDR489W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SLD3 |
YGL113W |
Protein involved in the initiation of DNA replication |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| POL31 |
YJR006W |
Subunit of DNA polymerase delta (polymerase III) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MSN2 |
YMR037C |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
| MSN4 |
YKL062W |
Stress-responsive transcriptional activator |
regulation |
1 |
1 |
1 |
RNA-sequencing evidence |
| YRR1 |
YOR162C |
Zn2-Cys6 zinc-finger transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSY2 |
YNL201C |
Subunit of protein phosphatase PP4 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HPR1 |
YDR138W |
Subunit of THO/TREX complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PEP1 |
YBL017C |
Type I transmembrane sorting receptor for multiple vacuolar hydrolases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| COX6 |
YHR051W |
Subunit VI of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MBP1 |
YDL056W |
Transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCM6 |
YGL201C |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEC1 |
YBR136W |
Genome integrity checkpoint protein and PI kinase superfamily member |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MLC1 |
YGL106W |
Essential light chain for Myo1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MYO4 |
YAL029C |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NUP116 |
YMR047C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST1 |
YJL002C |
Alpha subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
1 |
1 |
1 |
Dosage Lethality |
| DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MET18 |
YIL128W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP84 |
YDL116W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD1 |
YPL022W |
Single-stranded DNA endonuclease (with Rad10p) |
physical |
1 |
1 |
1 |
Co-purification |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HEL2 |
YDR266C |
RING finger ubiquitin ligase (E3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PPQ1 |
YPL179W |
Protein phosphatase that regulates the mating response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PPZ2 |
YDR436W |
Serine/threonine protein phosphatase Z, isoform of Ppz1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GAC1 |
YOR178C |
Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MEK1 |
YOR351C |
Meiosis-specific serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| RAD14 |
YMR201C |
Subunit of Nucleotide Excision Repair Factor 1 (NEF1) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| FPK1 |
YNR047W |
Ser/Thr protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTC2 |
YER089C |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCM4 |
YPR019W |
Essential helicase component of heterohexameric MCM2-7 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIG1 |
YGL035C |
Transcription factor involved in glucose repression |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEC3 |
YLR288C |
DNA damage and meiotic pachytene checkpoint protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHR2 |
YKL078W |
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KKQ8 |
YKL168C |
Putative serine/threonine protein kinase with unknown cellular role |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DCK1 |
YLR422W |
Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUP2 |
YGL166W |
Copper-binding transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIR5 |
YJL160C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUR6 |
YER159C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDM12 |
YOL009C |
Mitochondrial outer membrane protein, ERMES complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YEL023C |
YEL023C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
physical |
1 |
1 |
1 |
Two-hybrid |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RTT105 |
YER104W |
Chaperone for Replication Protein A complex (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRF5 |
YNL299W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA2 |
YNL312W |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSC6 |
YCR052W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TDP1 |
YBR223C |
Tyrosyl-DNA phosphodiesterase I |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| UBC13 |
YDR092W |
E2 ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RNR4 |
YGR180C |
Ribonucleotide-diphosphate reductase (RNR) small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMC6 |
YLR383W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| UNG1 |
YML021C |
Uracil-DNA glycosylase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RUB1 |
YDR139C |
Ubiquitin-like protein with similarity to mammalian NEDD8 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| UBC12 |
YLR306W |
Enzyme that mediates the conjugation of Rub1p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TPP1 |
YMR156C |
DNA 3'-phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA3 |
YJL173C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAH11 |
YJR046W |
DNA replication licensing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ROF1 |
YHR177W |
Putative transcription factor containing a WOPR domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLL056C |
YLL056C |
NADH-dependent aldehyde reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMA2 |
YML066C |
Meiosis-specific prospore membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWS2 |
YNL081C |
Putative mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOP4 |
YJL192C |
ER-membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL8B |
YLL045C |
Ribosomal 60S subunit protein L8A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKU80 |
YMR106C |
Subunit of telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSK22 |
YCR073C |
MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UBP7 |
YIL156W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STN1 |
YDR082W |
Telomere end-binding and capping protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CST9 |
YLR394W |
SUMO E3 ligase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EMC1 |
YCL045C |
Member of conserved endoplasmic reticulum membrane complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| OSH3 |
YHR073W |
Member of an oxysterol-binding protein family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APN2 |
YBL019W |
Class II abasic (AP) endonuclease involved in repair of DNA damage |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| ASN1 |
YPR145W |
Asparagine synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ERV14 |
YGL054C |
COPII-coated vesicle protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NDJ1 |
YOL104C |
Protein that regulates meiotic SPB cohesion and telomere clustering |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GTB1 |
YDR221W |
Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EHT1 |
YBR177C |
Octanoyl-CoA:ethanol acyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP12 |
YFL014W |
Plasma membrane protein involved in maintaining membrane organization |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFS1 |
YCL017C |
Cysteine desulfurase involved in iron-sulfur cluster biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSI1 |
YDR026C |
RNA polymerase I termination factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MBR1 |
YKL093W |
Protein involved in mitochondrial functions and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CUP9 |
YPL177C |
Homeodomain-containing transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEM12 |
YDR047W |
Uroporphyrinogen decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HXT2 |
YMR011W |
High-affinity glucose transporter of the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI13 |
YLL031C |
ER membrane localized phosphoryltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLB6 |
YGR109C |
B-type cyclin involved in DNA replication during S phase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MNT2 |
YGL257C |
Mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIF1 |
YML061C |
DNA helicase, potent G-quadruplex DNA binder/unwinder |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| IRC21 |
YMR073C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MNL2 |
YLR057W |
Putative mannosidase involved in ER-associated protein degradation |
genetic |
1 |
1 |
1 |
Negative Genetic |
