Standard name Systematic name Name description Description
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit Spt4p/5p (DSIF) transcription elongation factor complex subunit; the Spt4/5 complex binds to ssRNA in a sequence-specific manner, and along with RNAP I and II has multiple roles regulating transcriptional elongation, RNA processing, quality control, and transcription-coupled repair; localizes to kinetochores and heterochromatin, influencing chromosomal dynamics and silencing; required for transcription through long trinucleotide repeats in ORFs and non-protein coding regions
Visualize the interactome of SPT4
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.403 0.452 0.475
Nucleus 0.891 0.871 0.851
Mito NaN NaN 0.071

GFP localization & abundance

GFP localization GFP abundance
nucleus 4490

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SPT4 9 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 17 5 13 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 8 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 6 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 5 2 5 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
RPB7 YDR404C RNA polymerase II subunit B16 physical 5 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
DST1 YGL043W General transcription elongation factor TFIIS genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality
BRE5 YNR051C Ubiquitin protease cofactor genetic 4 3 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 4 3 3 Negative Genetic, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 4 3 2 Synthetic Growth Defect, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 3 3 3 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 3 2 3 Synthetic Lethality, Dosage Rescue, Synthetic Lethality
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 3 2 2 Positive Genetic, Phenotypic Suppression, Phenotypic Suppression
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 3 2 2 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
RPB4 YJL140W RNA polymerase II subunit B32 physical 3 2 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPB11 YOL005C RNA polymerase II subunit B12.5 physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
ASF1 YJL115W Nucleosome assembly factor genetic 2 2 2 Negative Genetic, Synthetic Lethality
HHF1 YBR009C Histone H4 genetic 2 2 2 Negative Genetic, Phenotypic Suppression
HTZ1 YOL012C Histone variant H2AZ genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
HIR1 YBL008W Subunit of the HIR complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 2 2 2 Affinity Capture-Western, Biochemical Activity
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 2 2 2 Synthetic Lethality, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RPB5 YBR154C RNA polymerase subunit ABC27 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPB9 YGL070C RNA polymerase II subunit B12.6 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPO26 YPR187W RNA polymerase subunit ABC23 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SPT6 YGR116W Nucleosome remodeling protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
SUB1 YMR039C Transcriptional regulator genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
RTR1 YER139C Dual specificity protein phosphatase genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
RTT106 YNL206C Histone chaperone genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
DAS1 YJL149W Putative SCF ubiquitin ligase F-box protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
HIR1 YBL008W Subunit of the HIR complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PEF1 YGR058W Penta-EF-hand protein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPT6 YGR116W Nucleosome remodeling protein physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
SYS1 YJL004C Integral membrane protein of the Golgi genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
STE24 YJR117W Highly conserved zinc metalloprotease genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
UTH1 YKR042W Mitochondrial inner membrane protein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
VPS28 YPL065W Component of the ESCRT-I complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ELO3 YLR372W Elongase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PHO80 YOL001W Cyclin genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PEP8 YJL053W Vacuolar protein component of the retromer genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
OST5 YGL226C-A Zeta subunit of the oligosaccharyltransferase complex of the ER lumen genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SIL1 YOL031C Nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ERV14 YGL054C COPII-coated vesicle protein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CUE1 YMR264W Ubiquitin-binding protein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
HRD3 YLR207W ER membrane protein that plays a central role in ERAD genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG6 YOR002W ER-luminal alpha 1,3 glucosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
ILM1 YJR118C Protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG12 YNR030W Alpha-1,6-mannosyltransferase localized to the ER genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CCW12 YLR110C Cell wall mannoprotein genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SPC2 YML055W Subunit of signal peptidase complex genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
DIE2 YGR227W Dolichyl-phosphoglucose-dependent alpha-1,2-glucosyltransferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
MSC1 YML128C Protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
CNE1 YAL058W Calnexin genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
ALG8 YOR067C Glucosyl transferase genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SLP1 YOR154W Glycosylated integral ER membrane protein of unknown function genetic 2 1 1 Phenotypic Suppression, Phenotypic Suppression
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Synthetic Lethality
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Phenotypic Enhancement
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Synthetic Rescue
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Synthetic Lethality
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 1 1 1 Affinity Capture-MS
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Synthetic Lethality
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Phenotypic Suppression
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Synthetic Lethality
ABD1 YBR236C Methyltransferase physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Synthetic Rescue
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
NHP6B YBR089C-A High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 1 1 1 Affinity Capture-MS
HTA1 YDR225W Histone H2A genetic 1 1 1 Phenotypic Suppression
HTA2 YBL003C Histone H2A genetic 1 1 1 Positive Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Rescue
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 1 1 1 Synthetic Rescue
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Synthetic Rescue
RPB10 YOR210W RNA polymerase subunit ABC10-beta physical 1 1 1 Affinity Capture-MS
RPB8 YOR224C RNA polymerase subunit ABC14.5 physical 1 1 1 Affinity Capture-MS
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
MLH2 YLR035C Protein involved in mismatch repair and meiotic recombination genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation physical 1 1 1 Affinity Capture-MS
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) physical 1 1 1 Affinity Capture-MS
SPN1 YPR133C Protein involved in RNA polymerase II transcription physical 1 1 1 Affinity Capture-MS
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Synthetic Lethality
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) physical 1 1 1 Two-hybrid
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Synthetic Lethality
HTB1 YDR224C Histone H2B genetic 1 1 1 Phenotypic Suppression
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 1 1 1 Protein-peptide
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Synthetic Lethality
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Suppression
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Synthetic Growth Defect
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Biochemical Activity
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Synthetic Rescue
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Synthetic Growth Defect
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
CHZ1 YER030W Histone chaperone for Htz1p/H2A-H2B dimer genetic 1 1 1 Negative Genetic
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 PCA
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Rescue
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Synthetic Growth Defect
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes genetic 1 1 1 Synthetic Growth Defect
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Affinity Capture-MS
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
THI2 YBR240C Transcriptional activator of thiamine biosynthetic genes genetic 1 1 1 Synthetic Lethality
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
TEX1 YNL253W Protein involved in mRNA export genetic 1 1 1 Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Negative Genetic
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Positive Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Positive Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Positive Genetic
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Synthetic Rescue
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Rescue
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Phenotypic Suppression
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
TEN1 YLR010C Protein that regulates telomeric length genetic 1 1 1 Synthetic Growth Defect
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination genetic 1 1 1 Synthetic Rescue
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Synthetic Lethality
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Suppression
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Synthetic Lethality
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Negative Genetic
GAL10 YBR019C UDP-glucose-4-epimerase genetic 1 1 1 Synthetic Rescue
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Synthetic Growth Defect
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Negative Genetic
REC104 YHR157W Protein involved in early stages of meiotic recombination genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Positive Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Positive Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Positive Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 1 1 1 Positive Genetic
RTR1 YER139C Dual specificity protein phosphatase physical 1 1 1 Affinity Capture-MS
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Negative Genetic
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Synthetic Lethality
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Negative Genetic
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect