Standard name Systematic name Name description Description
SRP1 YNL189W Karyopherin alpha homolog Karyopherin alpha homolog; forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; involved in cotranslational protein degradation; binds ribosome-bound nascent polypeptides; Srp1p and Sts1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation
Visualize the interactome of SRP1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.556 0.427 0.794
ER 0.056 0.076 0.052
Golgi 0.065 0.064 NaN
Vac/Vac Memb 0.343 0.451 0.116

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nuclear periphery 2790

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SRP1 0 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 21 4 15 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
KAP95 YLR347C Karyopherin beta physical 20 5 17 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex physical 14 3 12 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex physical 13 3 10 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor physical 10 4 9 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Two-hybrid, Reconstituted Complex
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 9 5 7 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure
RRP6 YOR001W Nuclear exosome exonuclease component physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
STS1 YIR011C Protein required for localizing proteasomes to the nucleus physical 8 3 4 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 5 4 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Dosage Rescue
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 5 3 2 Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
DIS3 YOL021C Exosome core complex catalytic subunit physical 4 3 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue, Dosage Rescue
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 4 2 2 Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 3 2 3 Dosage Rescue, Negative Genetic, Dosage Rescue
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 3 2 3 Negative Genetic, Phenotypic Enhancement, Negative Genetic
PCT1 YGR202C Cholinephosphate cytidylyltransferase physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
NOP7 YGR103W Component of several different pre-ribosomal particles physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
THO2 YNL139C Subunit of the THO complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
HXK2 YGL253W Hexokinase isoenzyme 2 physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 3 2 1 Two-hybrid, Reconstituted Complex, Reconstituted Complex
MIG2 YGL209W Zinc finger transcriptional repressor physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
YRB1 YDR002W Ran GTPase binding protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) physical 2 2 2 Affinity Capture-MS, Two-hybrid
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 2 2 2 Proximity Label-MS, Affinity Capture-MS
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex physical 2 2 2 Affinity Capture-MS, Co-purification
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DIG2 YDR480W MAP kinase-responsive inhibitor of the Ste12p transcription factor physical 2 2 2 Affinity Capture-MS, Two-hybrid
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
ELP3 YPL086C Subunit of Elongator complex genetic 2 2 2 Phenotypic Suppression, Positive Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system physical 2 2 2 Reconstituted Complex, Two-hybrid
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RRP43 YCR035C Exosome non-catalytic core component physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 2 1 2 Reconstituted Complex, Reconstituted Complex
THI4 YGR144W Thiazole synthase physical 2 1 2 Two-hybrid, Two-hybrid
THR1 YHR025W Homoserine kinase physical 2 1 2 Two-hybrid, Two-hybrid
YPL088W YPL088W Putative aryl alcohol dehydrogenase physical 2 1 2 Two-hybrid, Two-hybrid
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FOL2 YGR267C GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis physical 2 1 2 Two-hybrid, Two-hybrid
GSP1 YLR293C Ran GTPase physical 2 1 2 Reconstituted Complex, Reconstituted Complex
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 2 1 2 Negative Genetic, Negative Genetic
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SPT2 YER161C Protein involved in negative regulation of transcription physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
CDD1 YLR245C Cytidine deaminase physical 2 1 2 Two-hybrid, Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 2 1 2 Two-hybrid, Two-hybrid
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
BNA6 YFR047C Quinolinate phosphoribosyl transferase physical 2 1 2 Two-hybrid, Two-hybrid
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FBP1 YLR377C Fructose-1,6-bisphosphatase physical 2 1 2 Two-hybrid, Two-hybrid
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
MET3 YJR010W ATP sulfurylase physical 2 1 2 Two-hybrid, Two-hybrid
PNC1 YGL037C Nicotinamidase that converts nicotinamide to nicotinic acid physical 2 1 2 Two-hybrid, Two-hybrid
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication physical 2 2 1 Reconstituted Complex, Protein-peptide
SRM1 YGL097W Nucleotide exchange factor for Gsp1p physical 2 2 1 Reconstituted Complex, Protein-peptide
HEH2 YDR458C Inner nuclear membrane (INM) protein physical 2 2 1 Co-crystal Structure, Reconstituted Complex
SRC1 YML034W Inner nuclear membrane protein physical 2 2 1 Co-crystal Structure, Reconstituted Complex
KAP123 YER110C Karyopherin beta physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
ARP2 YDL029W Essential component of the Arp2/3 complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex physical 1 1 1 Affinity Capture-MS
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex physical 1 1 1 Two-hybrid
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Biochemical Activity
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
HAS1 YMR290C ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis genetic 1 1 1 Negative Genetic
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P physical 1 1 1 Affinity Capture-MS
SMB1 YER029C Core Sm protein Sm B physical 1 1 1 Affinity Capture-MS
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA physical 1 1 1 Two-hybrid
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
AIR2 YDL175C RNA-binding subunit of the TRAMP nuclear RNA surveillance complex physical 1 1 1 Affinity Capture-MS
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-Western
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP4 YHR069C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP45 YDR280W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP42 YDL111C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP46 YGR095C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase physical 1 1 1 Affinity Capture-MS
HPR1 YDR138W Subunit of THO/TREX complexes physical 1 1 1 Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex physical 1 1 1 Affinity Capture-MS
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
SNP1 YIL061C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Dosage Rescue
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Two-hybrid
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Synthetic Rescue
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Affinity Capture-MS
YPR089W YPR089W Protein of unknown function physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 Affinity Capture-MS
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
URB2 YJR041C Protein required for normal metabolism of the rRNA primary transcript physical 1 1 1 Affinity Capture-MS
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
UBP2 YOR124C Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
TAN1 YGL232W Putative tRNA acetyltransferase physical 1 1 1 Affinity Capture-MS
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Biochemical Activity
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Co-localization
YBR137W YBR137W Protein with a role in ER delivery of tail-anchored membrane proteins physical 1 1 1 Two-hybrid
TVP15 YDR100W Integral membrane protein physical 1 1 1 Two-hybrid
TSA2 YDR453C Stress inducible cytoplasmic thioredoxin peroxidase physical 1 1 1 Two-hybrid
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Two-hybrid
THG1 YGR024C tRNAHis guanylyltransferase physical 1 1 1 Two-hybrid
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Two-hybrid
YJL218W YJL218W Mitochondrial protein, putative acetyltransferase physical 1 1 1 Two-hybrid
YJR056C YJR056C Protein of unknown function physical 1 1 1 Two-hybrid
YNK1 YKL067W Nucleoside diphosphate kinase physical 1 1 1 Two-hybrid
YIP3 YNL044W Protein localized to COPII vesicles physical 1 1 1 Two-hybrid
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes physical 1 1 1 Reconstituted Complex
YHR112C YHR112C Protein of unknown function physical 1 1 1 Two-hybrid
WTM2 YOR229W Transcriptional modulator physical 1 1 1 Two-hybrid
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 1 1 1 Reconstituted Complex
VPS75 YNL246W NAP family histone chaperone physical 1 1 1 Reconstituted Complex
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone physical 1 1 1 Affinity Capture-Western
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Synthetic Growth Defect
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
UBP15 YMR304W Ubiquitin-specific protease involved in protein deubiquitination physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Dosage Rescue
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Dosage Rescue
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Positive Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Positive Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Negative Genetic
TIM22 YDL217C Essential core component of mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
TFC8 YPL007C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
YRB30 YGL164C RanGTP-binding protein genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YGR127W YGR127W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
YKL162C YKL162C Putative protein of unknown function genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Negative Genetic
IMD2 YHR216W Inosine monophosphate dehydrogenase physical 1 1 1 Two-hybrid
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein physical 1 1 1 Affinity Capture-MS
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) genetic 1 1 1 Negative Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Synthetic Lethality
CAR1 YPL111W Arginase, catabolizes arginine to ornithine and urea physical 1 1 1 Two-hybrid
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p physical 1 1 1 Affinity Capture-MS
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor physical 1 1 1 Reconstituted Complex
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex physical 1 1 1 Affinity Capture-MS
ERO1 YML130C Thiol oxidase required for oxidative protein folding in the ER genetic 1 1 1 Positive Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) physical 1 1 1 Affinity Capture-MS
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-Western
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-Western
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MED2 YDL005C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
PAP1 YKR002W Poly(A) polymerase physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Two-hybrid
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor physical 1 1 1 Two-hybrid
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Phenotypic Suppression
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) physical 1 1 1 Two-hybrid
PRP4 YPR178W Splicing factor genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) physical 1 1 1 Affinity Capture-MS
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Positive Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex physical 1 1 1 Affinity Capture-MS
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex physical 1 1 1 Affinity Capture-MS
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex physical 1 1 1 Affinity Capture-MS
SKI6 YGR195W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Positive Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 1 1 1 Affinity Capture-Western
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Negative Genetic
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex physical 1 1 1 Two-hybrid
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-MS
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Positive Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex physical 1 1 1 Affinity Capture-MS
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Negative Genetic
SDH2 YLL041C Iron-sulfur protein subunit of succinate dehydrogenase genetic 1 1 1 Negative Genetic
NMD5 YJR132W Karyopherin genetic 1 1 1 Dosage Rescue
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Positive Genetic
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Two-hybrid
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Affinity Capture-MS
PDS1 YDR113C Securin physical 1 1 1 Affinity Capture-MS
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Two-hybrid
APE1 YKL103C Vacuolar aminopeptidase yscI physical 1 1 1 Two-hybrid
LSB1 YGR136W Negative regulator of actin nucleation-promoting factor activity physical 1 1 1 Two-hybrid
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
NUP49 YGL172W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Phenotypic Suppression
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Positive Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
ISN1 YOR155C Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase physical 1 1 1 Two-hybrid
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 1 1 1 Affinity Capture-MS
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Synthetic Rescue
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Biochemical Activity
ACS1 YAL054C Acetyl-coA synthetase isoform physical 1 1 1 Two-hybrid
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein physical 1 1 1 Affinity Capture-MS
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Negative Genetic
SAN1 YDR143C Ubiquitin-protein ligase physical 1 1 1 Affinity Capture-MS
FUB1 YCR076C Proteasome-binding protein physical 1 1 1 Two-hybrid
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 1 1 1 Affinity Capture-MS
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Positive Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PML1 YLR016C Subunit of the RES complex physical 1 1 1 Affinity Capture-MS
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
NMA1 YLR328W Nicotinic acid mononucleotide adenylyltransferase physical 1 1 1 Two-hybrid
CLN3 YAL040C G1 cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
ECM31 YBR176W Ketopantoate hydroxymethyltransferase physical 1 1 1 Two-hybrid
CUP2 YGL166W Copper-binding transcription factor physical 1 1 1 Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 1 1 1 Two-hybrid
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NIF3 YGL221C Protein of unknown function physical 1 1 1 Two-hybrid
HUA2 YOR284W Cytoplasmic protein of unknown function physical 1 1 1 Two-hybrid
HSP10 YOR020C Mitochondrial matrix co-chaperonin physical 1 1 1 Two-hybrid
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
PCL8 YPL219W Cyclin genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Positive Genetic
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
MCO14 YHL018W Putative 4a-hydroxytetrahydrobiopterin dehydratase physical 1 1 1 Two-hybrid
SAE2 YGL175C Endonuclease required for telomere elongation physical 1 1 1 Two-hybrid
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
NMA2 YGR010W Nicotinic acid mononucleotide adenylyltransferase physical 1 1 1 Two-hybrid
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
MCM1 YMR043W Transcription factor genetic 1 1 1 Positive Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease physical 1 1 1 Affinity Capture-MS
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Positive Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Positive Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Negative Genetic
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
FUS2 YMR232W Cell fusion regulator physical 1 1 1 Affinity Capture-Western
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Positive Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Positive Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
RLM1 YPL089C MADS-box transcription factor physical 1 1 1 Affinity Capture-MS
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Positive Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Positive Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
HPA2 YPR193C Tetrameric histone acetyltransferase physical 1 1 1 Two-hybrid
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
SNZ3 YFL059W Pyridoxal-5'-phosphate synthase physical 1 1 1 Two-hybrid
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Two-hybrid
CAT2 YML042W Carnitine acetyl-CoA transferase physical 1 1 1 Two-hybrid
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate physical 1 1 1 Two-hybrid
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine genetic 1 1 1 Negative Genetic
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
GLK1 YCL040W Glucokinase physical 1 1 1 Two-hybrid
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Negative Genetic
BUD23 YCR047C Ribosome biogenesis factor genetic 1 1 1 Synthetic Growth Defect
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 1 1 1 Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SQS1 YNL224C Protein that stimulates the ATPase and helicase activities of Prp43p physical 1 1 1 Affinity Capture-MS
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RDR1 YOR380W Transcriptional repressor involved in regulating multidrug resistance physical 1 1 1 Two-hybrid
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase physical 1 1 1 Two-hybrid
LIP1 YMR298W Ceramide synthase subunit genetic 1 1 1 Positive Genetic
CTA1 YDR256C Catalase A physical 1 1 1 Two-hybrid
HPA3 YEL066W D-Amino acid N-acetyltransferase that detoxifies D-amino acids physical 1 1 1 Two-hybrid
HEM2 YGL040C Aminolevulinate dehydratase physical 1 1 1 Two-hybrid
APE4 YHR113W Cytoplasmic aspartyl aminopeptidase with possible vacuole function physical 1 1 1 Two-hybrid
RIB3 YDR487C 3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase) physical 1 1 1 Two-hybrid
PNP1 YLR209C Purine nucleoside phosphorylase physical 1 1 1 Two-hybrid
AAD14 YNL331C Putative aryl-alcohol dehydrogenase physical 1 1 1 Two-hybrid
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
CGR1 YGL029W Protein involved in nucleolar integrity and processing of pre-rRNA genetic 1 1 1 Negative Genetic
FAD1 YDL045C Flavin adenine dinucleotide (FAD) synthetase genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Positive Genetic
PIG2 YIL045W Putative type-1 protein phosphatase targeting subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SNG1 YGR197C Protein involved in resistance to nitrosoguanidine and 6-azauracil genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic