Standard name Systematic name Name description Description
CDC5 YMR001C Polo-like kinase required for mitotic exit Polo-like kinase required for mitotic exit; regulates mitotic spindle assembly, nuclear shape, and protein localization to the nucleolus and SPBs; controls targeting and activation of Rho1p at the division site via Rho1p-GEFs; role in adaptation to DNA damage promotes genome instability during replicative senescence; regulates meiotic spindle assembly, chiasmata formation, resolution of recombination intermediates and SC disassembly; human homologs PLK1 and PLK3 complement cdc5 mutants
Visualize the interactome of CDC5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 106

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.644 0.662 0.749
Endosome 0.074 NaN NaN
Nucleolus 0.104 NaN NaN
SpindlePole 0.092 NaN 0.068
Vac/Vac Memb 0.092 0.099 NaN
Mito NaN 0.116 NaN
Nucleus NaN 0.085 0.068

GFP localization & abundance

GFP localization GFP abundance
bud neck, nucleus 1480

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CDC5 0 10 0 1 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 11 5 9 Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex physical 11 7 7 Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Affinity Capture-MS, Two-hybrid, Two-hybrid, Protein-peptide, Two-hybrid, Co-crystal Structure, Reconstituted Complex, Two-hybrid
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 11 4 7 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p physical 9 3 8 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Two-hybrid, Biochemical Activity
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 9 3 8 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
SPC72 YAL047C Gamma-tubulin small complex (gamma-TuSC) receptor physical 9 7 7 Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Protein-peptide, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Two-hybrid
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 9 4 7 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 9 4 6 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Co-localization, Biochemical Activity, Two-hybrid, Two-hybrid
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex physical 8 4 8 Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, Co-purification, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western
BUB2 YMR055C Mitotic exit network regulator genetic 7 3 6 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 6 3 6 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 6 3 4 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Phenotypic Suppression
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 6 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 5 4 5 Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
REC8 YPR007C Meiosis-specific component of the sister chromatid cohesion complex physical 5 4 4 Co-localization, Biochemical Activity, Affinity Capture-MS, Co-purification, Affinity Capture-MS
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 5 3 4 Biochemical Activity, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
RAD53 YPL153C DNA damage response kinase physical 5 2 4 Affinity Capture-Western, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
SPO12 YHR152W Nucleolar protein of unknown function genetic 5 3 3 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 4 4 4 Two-hybrid, Co-localization, Affinity Capture-Western, Biochemical Activity
MPS3 YJL019W Nuclear envelope protein physical 4 3 4 Two-hybrid, Two-hybrid, Affinity Capture-MS, Proximity Label-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 4 3 3 Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 4 3 3 Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Lethality
CSE4 YKL049C Centromeric histone H3-like protein physical 4 3 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) physical 4 2 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 3 3 3 Biochemical Activity, Affinity Capture-MS, Two-hybrid
CSA1 YPR174C Protein of unknown function physical 3 3 3 Two-hybrid, Proximity Label-MS, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 3 2 3 Affinity Capture-MS, Biochemical Activity, Biochemical Activity
NET1 YJL076W Core subunit of the RENT complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein physical 3 2 3 Biochemical Activity, Biochemical Activity, Reconstituted Complex
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 2 3 Dosage Lethality, Dosage Lethality, Phenotypic Enhancement
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 3 2 3 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 3 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 3 1 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 3 3 2 Affinity Capture-Western, Two-hybrid, Proximity Label-MS
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 3 2 2 Dosage Lethality, Dosage Lethality, Dosage Rescue
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 3 2 2 Dosage Lethality, Dosage Lethality, Dosage Rescue
BBP1 YPL255W Protein required for the spindle pole body (SPB) duplication physical 3 2 2 Reconstituted Complex, Two-hybrid, Reconstituted Complex
CSE4 YKL049C Centromeric histone H3-like protein regulation 3 3 1 co-immunoprecipitation evidence, protein kinase assay evidence, qualitative western immunoblotting evidence
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 3 3 1 Two-hybrid, Co-localization, Biochemical Activity
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease physical 3 3 1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 3 2 1 Dosage Lethality, Dosage Lethality, Synthetic Rescue
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
NET1 YJL076W Core subunit of the RENT complex physical 2 2 2 Biochemical Activity, Proximity Label-MS
SLK19 YOR195W Kinetochore-associated protein physical 2 2 2 Biochemical Activity, Affinity Capture-Western
CNM67 YNL225C Component of the spindle pole body outer plaque physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Dosage Lethality, Synthetic Growth Defect
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 2 2 2 Dosage Rescue, Synthetic Rescue
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 2 2 2 Biochemical Activity, Affinity Capture-MS
AMN1 YBR158W Modulator of cell separation and mitotic exit genetic 2 1 2 Dosage Lethality, Dosage Lethality
IRR1 YIL026C Subunit of the cohesin complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
KAP95 YLR347C Karyopherin beta physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SRP1 YNL189W Karyopherin alpha homolog physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 2 1 2 Co-localization, Co-localization
MIH1 YMR036C Protein tyrosine phosphatase physical 2 1 2 Biochemical Activity, Biochemical Activity
RSC2 YLR357W Component of the RSC chromatin remodeling complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
MYO1 YHR023W Type II myosin heavy chain genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NDT80 YHR124W Meiosis-specific transcription factor genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
NDT80 YHR124W Meiosis-specific transcription factor regulation 2 2 1 northern blot evidence, RNA-sequencing evidence
FKH2 YNL068C Forkhead family transcription factor physical 2 2 1 Reconstituted Complex, Biochemical Activity
SPO13 YHR014W Meiotic regulator physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 2 2 1 Synthetic Rescue, Dosage Rescue
SAE2 YGL175C Endonuclease required for telomere elongation physical 2 2 1 Two-hybrid, Reconstituted Complex
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication physical 2 2 1 Affinity Capture-Western, Biochemical Activity
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 2 2 1 Dosage Rescue, Synthetic Lethality
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
BNS1 YGR230W Protein of unknown function genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) regulation 1 1 1 qualitative western immunoblotting evidence
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication regulation 1 1 1 protein kinase assay evidence
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex regulation 1 1 1 phosphatase assay evidence
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity regulation 1 1 1 protein kinase assay evidence
NDD1 YOR372C Transcriptional activator essential for nuclear division regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Affinity Capture-MS
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Synthetic Lethality
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Reconstituted Complex
BOI2 YER114C Protein involved in polar growth physical 1 1 1 Proximity Label-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 1 1 1 Two-hybrid
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Rescue
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) physical 1 1 1 Biochemical Activity
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Suppression
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Dosage Rescue
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
NOP13 YNL175C Nucleolar protein found in preribosomal complexes physical 1 1 1 Affinity Capture-MS
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Phenotypic Suppression
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Affinity Capture-Western
MAM1 YER106W Monopolin physical 1 1 1 Co-localization
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 1 1 1 Biochemical Activity
CMR3 YPR013C Putative zinc finger protein physical 1 1 1 Biochemical Activity
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
PTC1 YDL006W Type 2C protein phosphatase (PP2C) physical 1 1 1 Biochemical Activity
SWC5 YBR231C Component of the SWR1 complex physical 1 1 1 Biochemical Activity
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
IRC8 YJL051W Bud tip localized protein of unknown function physical 1 1 1 Biochemical Activity
RGC1 YPR115W Putative regulator of the Fps1p glycerol channel physical 1 1 1 Biochemical Activity
YMC1 YPR058W Secondary mitochondrial inner membrane glycine transporter physical 1 1 1 Biochemical Activity
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Biochemical Activity
NDD1 YOR372C Transcriptional activator essential for nuclear division physical 1 1 1 Biochemical Activity
NUD1 YOR373W Mitotic exit network (MEN) scaffold protein genetic 1 1 1 Dosage Rescue
GTT3 YEL017W Protein of unknown function may be involved in glutathione metabolism physical 1 1 1 Two-hybrid
IKS1 YJL057C Protein kinase of unknown cellular role physical 1 1 1 Two-hybrid
NBP1 YLR457C Spindle pole body (SPB) component physical 1 1 1 Two-hybrid
PRM3 YPL192C Protein required for nuclear envelope fusion during karyogamy physical 1 1 1 Two-hybrid
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Dosage Growth Defect
MPS1 YDL028C Dual-specificity kinase physical 1 1 1 Affinity Capture-Western
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Phenotypic Enhancement
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex physical 1 1 1 Affinity Capture-Western
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Synthetic Rescue
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Affinity Capture-Western
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Affinity Capture-Western
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Phenotypic Suppression
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family physical 1 1 1 Biochemical Activity
YOR192C-A YOR192C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Two-hybrid
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-Western
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Phenotypic Suppression
YDL186W YDL186W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit physical 1 1 1 Affinity Capture-MS
LDS1 YAL018C Protein Involved in spore wall assembly physical 1 1 1 Affinity Capture-MS
GIP1 YBR045C Meiosis-specific regulatory subunit of the Glc7p protein phosphatase physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
PEP4 YPL154C Vacuolar aspartyl protease (proteinase A) physical 1 1 1 Affinity Capture-MS
PAL2 YHR097C Protein involved in clathrin-mediated endocytosis physical 1 1 1 Affinity Capture-MS
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
HBT1 YDL223C Shmoo tip protein, substrate of Hub1p ubiquitin-like protein physical 1 1 1 Affinity Capture-MS
MIP6 YHR015W Putative RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex physical 1 1 1 Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-MS
DON1 YDR273W Meiosis-specific component of the spindle pole body physical 1 1 1 Affinity Capture-MS
TUB1 YML085C Alpha-tubulin physical 1 1 1 Affinity Capture-MS
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SSP1 YHR184W Protein involved in the control of meiotic nuclear division physical 1 1 1 Affinity Capture-MS
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 1 1 1 Affinity Capture-Western
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 1 1 1 Affinity Capture-Western
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Suppression
PDS5 YMR076C Cohesion maintenance factor physical 1 1 1 Affinity Capture-MS
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) physical 1 1 1 Affinity Capture-Western
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization genetic 1 1 1 Synthetic Growth Defect
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SEC4 YFL005W Rab family GTPase physical 1 1 1 Biochemical Activity
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage physical 1 1 1 Affinity Capture-Western
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 1 1 1 Biochemical Activity
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis physical 1 1 1 Affinity Capture-Western
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination physical 1 1 1 Affinity Capture-Western
HHF1 YBR009C Histone H4 physical 1 1 1 Biochemical Activity
PFY1 YOR122C Profilin physical 1 1 1 Proximity Label-MS
PRS1 YKL181W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Proximity Label-MS
YCP4 YCR004C Protein of unknown function physical 1 1 1 Proximity Label-MS
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Proximity Label-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis physical 1 1 1 Proximity Label-MS
FDO1 YMR144W Protein involved in directionality of mating type switching physical 1 1 1 Proximity Label-MS
GSH2 YOL049W Glutathione synthetase physical 1 1 1 Proximity Label-MS
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Proximity Label-MS
RPB9 YGL070C RNA polymerase II subunit B12.6 physical 1 1 1 Proximity Label-MS
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Proximity Label-MS
VTC1 YER072W Regulatory subunit of the vacuolar transporter chaperone (VTC) complex physical 1 1 1 Proximity Label-MS
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) physical 1 1 1 Proximity Label-MS
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation physical 1 1 1 Proximity Label-MS
UTP6 YDR449C Nucleolar protein physical 1 1 1 Proximity Label-MS
DTD1 YDL219W D-Tyr-tRNA(Tyr) deacylase physical 1 1 1 Proximity Label-MS
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Dosage Rescue
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Dosage Rescue
RSR1 YGR152C Ras-type GTPase genetic 1 1 1 Dosage Rescue
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Dosage Rescue
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
GIC1 YHR061C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Lethality
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Synthetic Lethality
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Synthetic Lethality
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Dosage Lethality
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Phenotypic Enhancement
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Dosage Lethality
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Dosage Lethality
RCF1 YML030W Cytochrome c oxidase subunit genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 1 1 1 Negative Genetic
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Positive Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Positive Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Phenotypic Enhancement
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Dosage Rescue
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Synthetic Rescue
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Dosage Rescue
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Dosage Rescue
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Dosage Lethality
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog genetic 1 1 1 Positive Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Positive Genetic
PLM2 YDR501W Putative transcription factor, contains Forkhead Associated domain genetic 1 1 1 Positive Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Positive Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Synthetic Growth Defect
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
PRT1 YOR361C eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Growth Defect
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 1 1 1 Synthetic Growth Defect
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 1 1 1 Dosage Rescue
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Synthetic Rescue
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Synthetic Rescue
YEN1 YER041W Holliday junction resolvase genetic 1 1 1 Synthetic Growth Defect
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Synthetic Lethality
LCD1 YDR499W Essential protein required for the DNA integrity checkpoint pathways genetic 1 1 1 Phenotypic Suppression
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Phenotypic Suppression
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
BUB2 YMR055C Mitotic exit network regulator physical 1 1 1 Affinity Capture-Western
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Synthetic Lethality
BEM3 YPL115C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Reconstituted Complex
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Biochemical Activity
ARF2 YDL137W ADP-ribosylation factor physical 1 1 1 Proximity Label-MS
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Suppression
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Biochemical Activity
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Affinity Capture-MS
AMA1 YGR225W Activator of meiotic anaphase promoting complex (APC/C) genetic 1 1 1 Phenotypic Suppression
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Negative Genetic
ACM1 YPL267W Pseudosubstrate inhibitor of the APC/C genetic 1 1 1 Phenotypic Enhancement