Standard name Systematic name Name description Description
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) Subunit of telomeric Ku complex (Yku70p-Yku80p); involved in telomere length maintenance, structure and telomere position effect; required for localization of telomerase ribonucleoprotein via interaction with TLC1 guide RNA; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair; colocalizes with quiescent cell telomere hyperclusters
Visualize the interactome of YKU80
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.240 NaN NaN
Nucleus 0.760 0.849 0.984
Vac/Vac Memb 0.133 0.146 NaN
Cytoplasm NaN 0.052 NaN

GFP localization & abundance

GFP localization GFP abundance
nucleus 358

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YKU80 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) physical 14 4 11 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 12 7 9 Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 9 5 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 8 4 7 Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 7 4 6 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 7 4 5 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
RAD52 YML032C Protein involved in homologous recombination genetic 6 3 6 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression
DIA2 YOR080W Origin-binding F-box protein genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement
EST3 YIL009C-A Component of the telomerase holoenzyme genetic 4 3 3 Dosage Growth Defect, Dosage Lethality, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 4 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 3 3 3 Phenotypic Enhancement, Dosage Lethality, Dosage Growth Defect
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
CDC73 YLR418C Component of the Paf1p complex genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 2 2 2 Dosage Lethality, Phenotypic Enhancement
PHO85 YPL031C Cyclin-dependent kinase physical 2 2 2 Affinity Capture-MS, Biochemical Activity
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Phenotypic Suppression, Positive Genetic
SAC3 YDR159W mRNA export factor genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
HHT2 YNL031C Histone H3 physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
TRM2 YKR056W tRNA methyltransferase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
NPL3 YDR432W RNA-binding protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
YPT31 YER031C Rab family GTPase genetic 2 1 2 Negative Genetic, Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 2 1 2 Negative Genetic, Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 2 2 1 Affinity Capture-MS, Co-fractionation
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SUA5 YGL169W Protein involved in threonylcarbamoyl adenosine biosynthesis genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MOT3 YMR070W Transcriptional repressor, activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Phenotypic Enhancement
FUN12 YAL035W Translation initiation factor eIF5B physical 1 1 1 Affinity Capture-MS
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Phenotypic Enhancement
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Positive Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Phenotypic Enhancement
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Phenotypic Enhancement
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Phenotypic Enhancement
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Phenotypic Enhancement
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Phenotypic Enhancement
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
NOG2 YNR053C Putative GTPase physical 1 1 1 Affinity Capture-MS
AVO1 YOL078W Component of the membrane-bound TORC2 complex physical 1 1 1 Affinity Capture-MS
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Phenotypic Enhancement
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Phenotypic Enhancement
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Phenotypic Enhancement
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 1 1 1 Phenotypic Enhancement
HTB2 YBL002W Histone H2B physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
LST8 YNL006W Protein required for the transport of Gap1p physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Phenotypic Enhancement
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Phenotypic Enhancement
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Phenotypic Suppression
LYS12 YIL094C Homo-isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Phenotypic Enhancement
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Phenotypic Enhancement
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Phenotypic Enhancement
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Phenotypic Enhancement
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Positive Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Phenotypic Enhancement
HTA1 YDR225W Histone H2A physical 1 1 1 Affinity Capture-MS
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase physical 1 1 1 Affinity Capture-MS
RAD51 YER095W Strand exchange protein genetic 1 1 1 Phenotypic Enhancement
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Phenotypic Enhancement
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Phenotypic Enhancement
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Phenotypic Enhancement
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Phenotypic Enhancement
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Phenotypic Enhancement
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Phenotypic Enhancement
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Phenotypic Enhancement
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase physical 1 1 1 Affinity Capture-MS
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex physical 1 1 1 Affinity Capture-MS
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Growth Defect
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) physical 1 1 1 Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Phenotypic Enhancement
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Phenotypic Enhancement
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Phenotypic Enhancement
SAW1 YAL027W 5'- and 3'-flap DNA binding protein genetic 1 1 1 Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Phenotypic Enhancement
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Phenotypic Enhancement
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-MS
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen physical 1 1 1 Affinity Capture-MS
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor physical 1 1 1 Affinity Capture-MS
ATP3 YBR039W Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
LAM5 YFL042C Putative sterol transfer protein genetic 1 1 1 Phenotypic Enhancement
FOL2 YGR267C GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis physical 1 1 1 Affinity Capture-MS
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) physical 1 1 1 Affinity Capture-MS
PST2 YDR032C FMN-dependent NAD(P)H:quinone oxidoreductase physical 1 1 1 Affinity Capture-MS
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
FKH1 YIL131C Forkhead family transcription factor genetic 1 1 1 Phenotypic Suppression
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Phenotypic Enhancement
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Phenotypic Enhancement
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Dosage Lethality
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Phenotypic Enhancement
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Phenotypic Enhancement
SOD2 YHR008C Mitochondrial manganese superoxide dismutase physical 1 1 1 Affinity Capture-MS
DSS1 YMR287C 3'-5' exoribonuclease physical 1 1 1 Affinity Capture-MS
TSA2 YDR453C Stress inducible cytoplasmic thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
YHR033W YHR033W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 1 1 1 Affinity Capture-MS
YML020W YML020W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YPR003C YPR003C Putative sulfate permease physical 1 1 1 Affinity Capture-MS
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Phenotypic Enhancement
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex physical 1 1 1 Affinity Capture-MS
APT1 YML022W Adenine phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
NPA3 YJR072C Member of the conserved GPN-loop GTPase family physical 1 1 1 Affinity Capture-MS
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) physical 1 1 1 Two-hybrid
GAL7 YBR018C Galactose-1-phosphate uridyl transferase physical 1 1 1 Affinity Capture-MS
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex physical 1 1 1 Affinity Capture-MS
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) physical 1 1 1 Affinity Capture-MS
RAD24 YER173W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Phenotypic Enhancement
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Phenotypic Enhancement
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Phenotypic Enhancement
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 1 1 1 Two-hybrid
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
MKK2 YPL140C MAPKK involved in the protein kinase C signaling pathway physical 1 1 1 Affinity Capture-MS
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Phenotypic Enhancement
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Phenotypic Enhancement
ILV2 YMR108W Acetolactate synthase physical 1 1 1 Affinity Capture-MS
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase physical 1 1 1 Affinity Capture-MS
SEC4 YFL005W Rab family GTPase genetic 1 1 1 Phenotypic Enhancement
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Phenotypic Enhancement
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Dosage Rescue
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Synthetic Growth Defect
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Rescue
LIF1 YGL090W Component of the DNA ligase IV complex genetic 1 1 1 Phenotypic Enhancement
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Phenotypic Enhancement
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
HFL1 YKR051W Vacuole membrane protein that interacts with Atg8p physical 1 1 1 Affinity Capture-MS
RRP3 YHR065C Protein involved in rRNA processing physical 1 1 1 Affinity Capture-MS
MET16 YPR167C 3'-phosphoadenylsulfate reductase physical 1 1 1 Affinity Capture-MS
YBT1 YLL048C Transporter of the ATP-binding cassette (ABC) family physical 1 1 1 Affinity Capture-MS
YGR266W YGR266W Protein of unknown function physical 1 1 1 Affinity Capture-MS
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 Affinity Capture-MS
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit physical 1 1 1 Affinity Capture-MS
CMG1 YLR271W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
MRX1 YER077C Protein that associates with mitochondrial ribosome physical 1 1 1 Affinity Capture-MS
SLX1 YBR228W Endonuclease involved in DNA recombination and repair physical 1 1 1 Affinity Capture-MS
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Phenotypic Enhancement
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Phenotypic Enhancement
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Negative Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Phenotypic Enhancement
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Phenotypic Enhancement
SIR3 YLR442C Silencing protein genetic 1 1 1 Synthetic Growth Defect
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Enhancement
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Phenotypic Enhancement
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Phenotypic Enhancement
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Phenotypic Enhancement
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Phenotypic Enhancement
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Phenotypic Enhancement
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Phenotypic Enhancement
CSM3 YMR048W Replication fork associated factor genetic 1 1 1 Phenotypic Enhancement
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Dosage Growth Defect
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Phenotypic Enhancement
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Enhancement
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Phenotypic Enhancement
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Phenotypic Enhancement
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Phenotypic Enhancement
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Phenotypic Enhancement
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Phenotypic Enhancement
RSC1 YGR056W Component of the RSC chromatin remodeling complex physical 1 1 1 Two-hybrid
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Phenotypic Enhancement
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-Western
MSN2 YMR037C Stress-responsive transcriptional activator genetic 1 1 1 Phenotypic Suppression
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Phenotypic Enhancement
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Phenotypic Enhancement
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Phenotypic Enhancement
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Phenotypic Enhancement
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Phenotypic Enhancement
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Phenotypic Enhancement
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Phenotypic Enhancement
SEC6 YIL068C Essential 88kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Enhancement
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Phenotypic Enhancement
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Phenotypic Enhancement
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Phenotypic Enhancement
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Phenotypic Enhancement
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Phenotypic Enhancement
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Phenotypic Enhancement
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Phenotypic Enhancement
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Phenotypic Enhancement
SEC5 YDR166C Essential 107kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Enhancement
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Phenotypic Enhancement
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Phenotypic Enhancement
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Phenotypic Enhancement
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Phenotypic Enhancement
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Phenotypic Enhancement
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Synthetic Rescue
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Phenotypic Suppression
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 1 1 1 Affinity Capture-MS
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Phenotypic Enhancement
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Phenotypic Enhancement
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Phenotypic Enhancement
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Phenotypic Enhancement
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Phenotypic Enhancement
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Phenotypic Enhancement
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-Western
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Phenotypic Enhancement
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Phenotypic Enhancement
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Phenotypic Enhancement
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Phenotypic Enhancement
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
FCY21 YER060W Putative purine-cytosine permease genetic 1 1 1 Phenotypic Enhancement
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Phenotypic Enhancement
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Phenotypic Suppression
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Phenotypic Enhancement
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Synthetic Growth Defect
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Phenotypic Enhancement
YGR130C YGR130C Component of the eisosome with unknown function genetic 1 1 1 Negative Genetic
RTR1 YER139C Dual specificity protein phosphatase genetic 1 1 1 Phenotypic Enhancement
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Phenotypic Enhancement
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Phenotypic Enhancement
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Phenotypic Suppression
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Phenotypic Enhancement
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Phenotypic Enhancement
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
THO1 YER063W Conserved nuclear RNA-binding protein genetic 1 1 1 Phenotypic Enhancement
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Phenotypic Enhancement
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme physical 1 1 1 Affinity Capture-Western
HVG1 YER039C Protein of unknown function genetic 1 1 1 Negative Genetic
MPS3 YJL019W Nuclear envelope protein genetic 1 1 1 Phenotypic Suppression
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Phenotypic Enhancement
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
DAL2 YIR029W Allantoicase genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Phenotypic Enhancement
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Phenotypic Enhancement
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Phenotypic Enhancement
YEA4 YEL004W Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter genetic 1 1 1 Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Positive Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Synthetic Growth Defect
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase physical 1 1 1 Affinity Capture-MS
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Phenotypic Enhancement
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Phenotypic Enhancement
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Phenotypic Enhancement
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Negative Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Phenotypic Enhancement
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic