AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
physical |
18 |
6 |
11 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Reconstituted Complex, PCA, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
physical |
10 |
6 |
6 |
Affinity Capture-Western, Co-localization, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Affinity Capture-MS, Protein-peptide, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS |
CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
physical |
8 |
4 |
5 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
physical |
7 |
2 |
7 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-crystal Structure, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
physical |
6 |
4 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS |
CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
5 |
4 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression |
AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
genetic |
5 |
2 |
4 |
Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic |
CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
physical |
5 |
2 |
4 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
physical |
4 |
2 |
4 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
HIR3 |
YJR140C |
Subunit of the HIR complex |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
TAP42 |
YMR028W |
Essential protein involved in the TOR signaling pathway |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
physical |
3 |
3 |
3 |
Affinity Capture-MS, Affinity Capture-Western, Two-hybrid |
MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
NKP1 |
YDR383C |
Central kinetochore protein and subunit of the Ctf19 complex |
physical |
3 |
2 |
3 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS |
NKP1 |
YDR383C |
Central kinetochore protein and subunit of the Ctf19 complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
CNN1 |
YFR046C |
Kinetochore protein |
genetic |
3 |
2 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
physical |
3 |
2 |
3 |
Affinity Capture-MS, Two-hybrid, Two-hybrid |
APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
3 |
3 |
2 |
Synthetic Growth Defect, Positive Genetic, Negative Genetic |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
3 |
2 |
2 |
Negative Genetic, Positive Genetic, Negative Genetic |
PRP4 |
YPR178W |
Splicing factor |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
3 |
2 |
2 |
Positive Genetic, Negative Genetic, Positive Genetic |
CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
physical |
3 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS |
DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
HHF2 |
YNL030W |
Histone H4 |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
physical |
2 |
2 |
2 |
Two-hybrid, Reconstituted Complex |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
APC2 |
YLR127C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-MS |
BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
INO2 |
YDR123C |
Transcription factor |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Rescue |
SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
physical |
2 |
2 |
2 |
Reconstituted Complex, Affinity Capture-MS |
RRP8 |
YDR083W |
Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase |
genetic |
2 |
2 |
2 |
Positive Genetic, Negative Genetic |
BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
KIP3 |
YGL216W |
Kinesin-related antiparallel sliding motor protein |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
2 |
1 |
2 |
DNA to cDNA expression microarray evidence, DNA to cDNA expression microarray evidence |
ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
KAP95 |
YLR347C |
Karyopherin beta |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CFT2 |
YLR115W |
Subunit of the mRNA cleavage and polyadenlylation factor (CPF) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HTA1 |
YDR225W |
Histone H2A |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
FUN30 |
YAL019W |
Snf2p family member with ATP-dependent chromatin remodeling activity |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GSP1 |
YLR293C |
Ran GTPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
KAP122 |
YGL016W |
Karyopherin beta |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
IPA1 |
YJR141W |
Protein implicated in pre-mRNA processing and proteasomal degradation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HIR2 |
YOR038C |
Subunit of HIR nucleosome assembly complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CNN1 |
YFR046C |
Kinetochore protein |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
physical |
2 |
1 |
2 |
Affinity Capture-MS, Affinity Capture-MS |
SUP35 |
YDR172W |
Translation termination factor eRF3 |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
PDS1 |
YDR113C |
Securin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPT1 |
YKL145W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TAD3 |
YLR316C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
ORC3 |
YLL004W |
Subunit of the origin recognition complex (ORC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWC3 |
YAL011W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
THR4 |
YCR053W |
Threonine synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PPM1 |
YDR435C |
Carboxyl methyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
SRB2 |
YHR041C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VRP1 |
YLR337C |
Verprolin, proline-rich actin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RRD2 |
YPL152W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CYK3 |
YDL117W |
SH3-domain protein located in the bud neck and cytokinetic actin ring |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
HUR1 |
YGL168W |
Protein with a role in DNA repair |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CEM1 |
YER061C |
Mitochondrial beta-keto-acyl synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DYN3 |
YMR299C |
Dynein light intermediate chain (LIC) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
RPS24A |
YER074W |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
HTA1 |
YDR225W |
Histone H2A |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
BOS1 |
YLR078C |
v-SNARE (vesicle specific SNAP receptor) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
NUP170 |
YBL079W |
Subunit of inner ring of nuclear pore complex (NPC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
PDE2 |
YOR360C |
High-affinity cyclic AMP phosphodiesterase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
ERG9 |
YHR190W |
Farnesyl-diphosphate farnesyl transferase (squalene synthase) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
1 |
1 |
1 |
ChEC-Seq experiments |
STP1 |
YDR463W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHD1 |
YER164W |
Chromatin remodeler that regulates various aspects of transcription |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC40 |
YDR364C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
GWT1 |
YJL091C |
Protein involved in the inositol acylation of GlcN-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
MES1 |
YGR264C |
Methionyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MAK21 |
YDR060W |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Positive Genetic |
LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
MED4 |
YOR174W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ABD1 |
YBR236C |
Methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ACC1 |
YNR016C |
Acetyl-CoA carboxylase, biotin containing enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARC40 |
YBR234C |
Subunit of the ARP2/3 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLP1 |
YOR250C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
physical |
1 |
1 |
1 |
Co-localization |
GCN3 |
YKR026C |
Alpha subunit of translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Positive Genetic |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
LAS17 |
YOR181W |
Actin assembly factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
KEL1 |
YHR158C |
Protein required for proper cell fusion and cell morphology |
genetic |
1 |
1 |
1 |
Positive Genetic |
COG3 |
YER157W |
Essential component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
physical |
1 |
1 |
1 |
Two-hybrid |
MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
genetic |
1 |
1 |
1 |
Positive Genetic |
GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NHP10 |
YDL002C |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
IES5 |
YER092W |
Non-essential INO80 chromatin remodeling complex subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
BLM10 |
YFL007W |
Proteasome activator |
genetic |
1 |
1 |
1 |
Positive Genetic |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
Reconstituted Complex |
GCN20 |
YFR009W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP85 |
YJR042W |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
MSH4 |
YFL003C |
Protein involved in meiotic recombination |
genetic |
1 |
1 |
1 |
Negative Genetic |
NEW1 |
YPL226W |
Translation termination and ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
1 |
1 |
1 |
Negative Genetic |
BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
1 |
1 |
1 |
Positive Genetic |
GET3 |
YDL100C |
Guanine nucleotide exchange factor for Gpa1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
DIA4 |
YHR011W |
Probable mitochondrial seryl-tRNA synthetase |
physical |
1 |
1 |
1 |
Two-hybrid |
LPL1 |
YOR059C |
Phospholipase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ABP1 |
YCR088W |
Actin-binding protein of the cortical actin cytoskeleton |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF20 |
YOR276W |
Phosphoprotein of the mRNA cap-binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
ASA1 |
YPR085C |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
IDH1 |
YNL037C |
Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Positive Genetic |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
EGD1 |
YPL037C |
Subunit beta1 of the nascent polypeptide-associated complex (NAC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ERG27 |
YLR100W |
3-keto sterol reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
DOP1 |
YDR141C |
Protein involved in vesicular transport at trans-Golgi network (TGN) |
genetic |
1 |
1 |
1 |
Positive Genetic |
AIP1 |
YMR092C |
Actin cortical patch component |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC37 |
YDR168W |
Essential Hsp90p co-chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Negative Genetic |
NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Positive Genetic |
CAC2 |
YML102W |
Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Dosage Lethality |
BEM4 |
YPL161C |
Protein involved in establishment of cell polarity and bud emergence |
genetic |
1 |
1 |
1 |
Negative Genetic |
HOM3 |
YER052C |
Aspartate kinase (L-aspartate 4-P-transferase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDH2 |
YOL126C |
Cytoplasmic malate dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
FKH2 |
YNL068C |
Forkhead family transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
LOS1 |
YKL205W |
Nuclear pore protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
DCS2 |
YOR173W |
m(7)GpppX pyrophosphatase regulator |
genetic |
1 |
1 |
1 |
Positive Genetic |
EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
DAD2 |
YKR083C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADE8 |
YDR408C |
Phosphoribosyl-glycinamide transformylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ATG1 |
YGL180W |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCM10 |
YIL150C |
Essential chromatin-associated protein |
physical |
1 |
1 |
1 |
Two-hybrid |
GDS1 |
YOR355W |
Protein involved in histone H4 acetylation at ribosomal protein genes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Positive Genetic |
CAK1 |
YFL029C |
Cyclin-dependent kinase-activating kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
OCA2 |
YNL056W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
genetic |
1 |
1 |
1 |
Negative Genetic |
CUB1 |
YPL260W |
Conserved fungal gene linked to DNA repair and proteasome function |
genetic |
1 |
1 |
1 |
Positive Genetic |
APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CEP3 |
YMR168C |
Essential kinetochore protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
physical |
1 |
1 |
1 |
Two-hybrid |
NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
AMD1 |
YML035C |
AMP deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIF2 |
YKL089W |
Centromeric CDEIII region binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELO2 |
YCR034W |
Fatty acid elongase, involved in sphingolipid biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
IOC2 |
YLR095C |
Subunit of the Isw1b complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
IOC4 |
YMR044W |
Member of a complex (Isw1b) with Isw1p and Ioc2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Negative Genetic |
MPS1 |
YDL028C |
Dual-specificity kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
CBF2 |
YGR140W |
Essential kinetochore protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
NMD2 |
YHR077C |
Protein involved in the nonsense-mediated mRNA decay (NMD) pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
1 |
1 |
1 |
Negative Genetic |
CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
ADY4 |
YLR227C |
Structural component of the meiotic outer plaque |
genetic |
1 |
1 |
1 |
Negative Genetic |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
KEX2 |
YNL238W |
Kexin, a subtilisin-like protease (proprotein convertase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
HPA2 |
YPR193C |
Tetrameric histone acetyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
CLB3 |
YDL155W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Negative Genetic |
MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
genetic |
1 |
1 |
1 |
Positive Genetic |
STE5 |
YDR103W |
Pheromone-responsive MAPK scaffold protein |
physical |
1 |
1 |
1 |
Two-hybrid |
PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOR342C |
YOR342C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PKP2 |
YGL059W |
Mitochondrial protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
physical |
1 |
1 |
1 |
Two-hybrid |
ZDS2 |
YML109W |
Protein with a role in regulating Swe1p-dependent polarized growth |
physical |
1 |
1 |
1 |
Two-hybrid |
YBP2 |
YGL060W |
Central kinetochore associated protein |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
YBP2 |
YGL060W |
Central kinetochore associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
physical |
1 |
1 |
1 |
Two-hybrid |
OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
TOR2 |
YKL203C |
PIK-related protein kinase and rapamycin target |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
PDB1 |
YBR221C |
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
YBR238C |
YBR238C |
Mitochondrial membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
VBA2 |
YBR293W |
Permease of basic amino acids in the vacuolar membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGF29 |
YCL010C |
Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Positive Genetic |
TIF2 |
YJL138C |
Translation initiation factor eIF4A |
genetic |
1 |
1 |
1 |
Positive Genetic |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
POL12 |
YBL035C |
B subunit of DNA polymerase alpha-primase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
YRB1 |
YDR002W |
Ran GTPase binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAB1 |
YER165W |
Poly(A) binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPI1 |
YFR003C |
Regulatory subunit of the type I protein phosphatase (PP1) Glc7p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA15 |
YGL044C |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TSC10 |
YBR265W |
3-ketosphinganine reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLU7 |
YDR088C |
RNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPC19 |
YDR201W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
SRP101 |
YDR292C |
Signal recognition particle (SRP) receptor alpha subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
UTP13 |
YLR222C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSC9 |
YML127W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAT1 |
YOR048C |
Nuclear 5' to 3' single-stranded RNA exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SGT1 |
YOR057W |
Cochaperone protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
TOA1 |
YOR194C |
TFIIA large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
SUA7 |
YPR086W |
Transcription factor TFIIB |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMP1 |
YLR145W |
Subunit of RNase MRP |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCS4 |
YLR272C |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMD2 |
YLR275W |
Core Sm protein Sm D2 |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TIF34 |
YMR146C |
eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSU72 |
YNL222W |
Phosphatase and transcription/RNA-processing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
WRS1 |
YOL097C |
Cytoplasmic tryptophanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
YTH1 |
YPR107C |
Essential RNA-binding component of cleavage and polyadenylation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
TCM62 |
YBR044C |
Protein involved in assembly of the succinate dehydrogenase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YCL002C |
YCL002C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
genetic |
1 |
1 |
1 |
Negative Genetic |
UFD2 |
YDL190C |
Ubiquitin (Ub) chain assembly factor (E4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPS2 |
YDR074W |
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA14 |
YDR156W |
RNA polymerase I subunit A14 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT103 |
YDR289C |
Protein involved in transcription termination by RNA polymerase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
YFT2 |
YDR319C |
Protein needed for ER membrane biosynthesis in response to ER stress |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
1 |
1 |
1 |
Negative Genetic |
XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAD1 |
YGL243W |
tRNA-specific adenosine deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PCI8 |
YIL071C |
Possible shared subunit of Cop9 signalosome (CSN) and eIF3 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS21B |
YJL136C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPO77 |
YLR341W |
Meiosis-specific protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
TSR2 |
YLR435W |
Protein with a potential role in pre-rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
YOX1 |
YML027W |
Homeobox transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
URA10 |
YMR271C |
Minor orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPP2A |
YOL039W |
Ribosomal protein P2 alpha |
genetic |
1 |
1 |
1 |
Negative Genetic |
ZEO1 |
YOL109W |
Peripheral membrane protein of the plasma membrane |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHR5 |
YOL110W |
Palmitoyltransferase subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS68 |
YOL129W |
Vacuolar membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SFL1 |
YOR140W |
Transcriptional repressor and activator |
genetic |
1 |
1 |
1 |
Negative Genetic |
SER1 |
YOR184W |
3-phosphoserine aminotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU66 |
YOR308C |
Component of the U4/U6.U5 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPL257W |
YPL257W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
THI22 |
YPR121W |
Protein with similarity to hydroxymethylpyrimidine phosphate kinases |
genetic |
1 |
1 |
1 |
Negative Genetic |
SCD6 |
YPR129W |
Repressor of translation initiation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
1 |
1 |
1 |
Negative Genetic |
YDL218W |
YDL218W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
PUS2 |
YGL063W |
Mitochondrial tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
OSH7 |
YHR001W |
Oxysterol-binding phosphatidylserine transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC22 |
YLR268W |
R-SNARE protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
YMR001C-A |
YMR001C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT21 |
YMR179W |
Protein with a role in transcriptional silencing |
genetic |
1 |
1 |
1 |
Negative Genetic |
SFB2 |
YNL049C |
Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat |
genetic |
1 |
1 |
1 |
Negative Genetic |
VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNC2 |
YOR327C |
Vesicle membrane receptor protein (v-SNARE) |
genetic |
1 |
1 |
1 |
Negative Genetic |
VTC3 |
YPL019C |
Regulatory subunit of the vacuolar transporter chaperone (VTC) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
RET2 |
YFR051C |
Delta subunit of the coatomer complex (COPI) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Positive Genetic |
PEX22 |
YAL055W |
Putative peroxisomal membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTC2 |
YBR147W |
Putative vacuolar membrane transporter for cationic amino acids |
genetic |
1 |
1 |
1 |
Positive Genetic |
RVS161 |
YCR009C |
Amphiphysin-like lipid raft protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
1 |
1 |
1 |
Positive Genetic |
QRI1 |
YDL103C |
UDP-N-acetylglucosamine pyrophosphorylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPP2B |
YDR382W |
Ribosomal protein P2 beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPS26B |
YER131W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
SKN7 |
YHR206W |
Nuclear response regulator and transcription factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
STS1 |
YIR011C |
Protein required for localizing proteasomes to the nucleus |
genetic |
1 |
1 |
1 |
Positive Genetic |
SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR011C |
YJR011C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
YJR124C |
YJR124C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
TEF4 |
YKL081W |
Gamma subunit of translational elongation factor eEF1B |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAP190 |
YKR028W |
Protein that forms a complex with the Sit4p protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
YSR3 |
YKR053C |
Dihydrosphingosine 1-phosphate phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Positive Genetic |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Positive Genetic |
TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Positive Genetic |
RFC4 |
YOL094C |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
STI1 |
YOR027W |
Evolutionarily-conserved Hsp90 cochaperone |
genetic |
1 |
1 |
1 |
Positive Genetic |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
1 |
1 |
1 |
Negative Genetic |
OST2 |
YOR103C |
Epsilon subunit of the oligosaccharyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
genetic |
1 |
1 |
1 |
Positive Genetic |
PPQ1 |
YPL179W |
Protein phosphatase that regulates the mating response |
genetic |
1 |
1 |
1 |
Positive Genetic |
RTC6 |
YPL183W-A |
Protein involved in translation |
genetic |
1 |
1 |
1 |
Positive Genetic |
PAN1 |
YIR006C |
Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p |
genetic |
1 |
1 |
1 |
Positive Genetic |
SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SRN2 |
YLR119W |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SLA1 |
YBL007C |
Cytoskeletal protein binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE7 |
YBL041W |
Beta 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRS23 |
YDR246W |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRI1 |
YIR008C |
Subunit of DNA primase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS24 |
YKL041W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEM1 |
YDR363W-A |
19S proteasome regulatory particle lid subcomplex component |
genetic |
1 |
1 |
1 |
Negative Genetic |
SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
POL32 |
YJR043C |
Third subunit of DNA polymerase delta |
genetic |
1 |
1 |
1 |
Negative Genetic |
PAM16 |
YJL104W |
Subunit of the import motor (PAM complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
genetic |
1 |
1 |
1 |
Dosage Lethality |
YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
BSC6 |
YOL137W |
Protein of unknown function with 8 putative transmembrane segments |
genetic |
1 |
1 |
1 |
Negative Genetic |
MXR1 |
YER042W |
Methionine-S-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BTT1 |
YDR252W |
Heterotrimeric nascent polypeptide-associated complex beta3 subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
1 |
1 |
1 |
Positive Genetic |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
BPH1 |
YCR032W |
Protein homologous to Chediak-Higashi syndrome and Beige proteins |
genetic |
1 |
1 |
1 |
Dosage Rescue |
NTH1 |
YDR001C |
Neutral trehalase, degrades trehalose |
genetic |
1 |
1 |
1 |
Negative Genetic |
AIM22 |
YJL046W |
Lipoate-protein ligase |
genetic |
1 |
1 |
1 |
Positive Genetic |
MVB12 |
YGR206W |
ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALD2 |
YMR170C |
Cytoplasmic aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
MRS2 |
YOR334W |
Mitochondrial inner membrane Mg(2+) channel |
genetic |
1 |
1 |
1 |
Negative Genetic |
IRC25 |
YLR021W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALT1 |
YLR089C |
Alanine transaminase (glutamic pyruvic transaminase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ERP3 |
YDL018C |
Protein with similarity to Emp24p and Erv25p |
physical |
1 |
1 |
1 |
Two-hybrid |
ACL4 |
YDR161W |
Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRX18 |
YBR056W |
Putative glycoside hydrolase of the mitochondrial intermembrane space |
genetic |
1 |
1 |
1 |
Negative Genetic |
LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
1 |
1 |
1 |
Negative Genetic |
MDM32 |
YOR147W |
Mitochondrial inner membrane protein with similarity to Mdm31p |
genetic |
1 |
1 |
1 |
Negative Genetic |
COS7 |
YDL248W |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
COX7 |
YMR256C |
Subunit VII of cytochrome c oxidase (Complex IV) |
genetic |
1 |
1 |
1 |
Positive Genetic |
KRE9 |
YJL174W |
Glycoprotein involved in cell wall beta-glucan assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
ARO7 |
YPR060C |
Chorismate mutase |
genetic |
1 |
1 |
1 |
Negative Genetic |
IRC24 |
YIR036C |
Putative benzil reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
FEX2 |
YPL279C |
Protein involved in fluoride export |
genetic |
1 |
1 |
1 |
Negative Genetic |
AVT5 |
YBL089W |
Putative transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
MHF2 |
YDL160C-A |
Component of the heterotetrameric MHF histone-fold complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MSC1 |
YML128C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
GRX7 |
YBR014C |
Cis-golgi localized monothiol glutaredoxin |
genetic |
1 |
1 |
1 |
Negative Genetic |
MCH4 |
YOL119C |
Protein with similarity to mammalian monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Negative Genetic |
APS3 |
YJL024C |
Small subunit of the clathrin-associated adaptor complex AP-3 |
genetic |
1 |
1 |
1 |
Positive Genetic |
MCT1 |
YOR221C |
Predicted malonyl-CoA:ACP transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HIM1 |
YDR317W |
Protein of unknown function involved in DNA repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
ALD3 |
YMR169C |
Cytoplasmic aldehyde dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMS2 |
YJR147W |
Protein with similarity to heat shock transcription factors |
physical |
1 |
1 |
1 |
Two-hybrid |
MLO1 |
YMR252C |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Positive Genetic |
MAN2 |
YNR073C |
Mannitol dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |