| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
10 |
3 |
7 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
10 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| KIP3 |
YGL216W |
Kinesin-related antiparallel sliding motor protein |
genetic |
9 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
8 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| ARP1 |
YHR129C |
Actin-related protein of the dynactin complex |
physical |
8 |
2 |
5 |
Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
8 |
2 |
5 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
physical |
8 |
3 |
4 |
Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Two-hybrid, Two-hybrid |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
physical |
7 |
2 |
6 |
Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western |
| BNI1 |
YNL271C |
Formin |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
7 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CLB4 |
YLR210W |
B-type cyclin involved in cell cycle progression |
genetic |
7 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| DNM1 |
YLL001W |
Dynamin-related GTPase involved in mitochondrial organization |
genetic |
7 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
7 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
6 |
2 |
5 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BOI2 |
YER114C |
Protein involved in polar growth |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| TUB3 |
YML124C |
Alpha-tubulin |
genetic |
6 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
6 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
5 |
3 |
4 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CAP1 |
YKL007W |
Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SSD1 |
YDR293C |
Translational repressor |
genetic |
5 |
2 |
4 |
Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| EAF7 |
YNL136W |
Subunit of the NuA4 histone acetyltransferase complex |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
5 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
5 |
2 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| VAM3 |
YOR106W |
Syntaxin-like vacuolar t-SNARE |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
genetic |
4 |
2 |
3 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| FIS1 |
YIL065C |
Protein involved in mitochondrial fission and peroxisome abundance |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| LDB18 |
YLL049W |
Component of the dynactin complex |
genetic |
4 |
1 |
3 |
Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic |
| YPT7 |
YML001W |
Rab family GTPase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| PSK2 |
YOL045W |
PAS-domain containing serine/threonine protein kinase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| LTE1 |
YAL024C |
Protein similar to GDP/GTP exchange factors |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Positive Genetic, Negative Genetic |
| ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| UBP9 |
YER098W |
Ubiquitin-specific protease that cleaves ubiquitin-protein fusions |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| PET8 |
YNL003C |
S-adenosylmethionine transporter of the mitochondrial inner membrane |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
physical |
3 |
1 |
3 |
Two-hybrid, Two-hybrid, Two-hybrid |
| SEY1 |
YOR165W |
Dynamin-like GTPase that mediates homotypic ER fusion |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
3 |
2 |
2 |
Positive Genetic, Positive Genetic, Negative Genetic |
| RPS6A |
YPL090C |
Protein component of the small (40S) ribosomal subunit |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Positive Genetic, Positive Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| BCK1 |
YJL095W |
MAPKKK acting in the protein kinase C signaling pathway |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CIN4 |
YMR138W |
GTP-binding protein involved in beta-tubulin (Tub2p) folding |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| INO2 |
YDR123C |
Transcription factor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
| RTG3 |
YBL103C |
bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| TOR1 |
YJR066W |
PIK-related protein kinase and rapamycin target |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SRP40 |
YKR092C |
Nucleolar serine-rich protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RPS29A |
YLR388W |
Protein component of the small (40S) ribosomal subunit |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MDV1 |
YJL112W |
Peripheral protein of cytosolic face of mitochondrial outer membrane |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PHO80 |
YOL001W |
Cyclin |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SET6 |
YPL165C |
SET domain protein of unknown function |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| KIP2 |
YPL155C |
Kinesin-related motor protein involved in mitotic spindle positioning |
genetic |
3 |
1 |
2 |
Positive Genetic, Positive Genetic, Positive Genetic |
| VAM7 |
YGL212W |
Vacuolar SNARE protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| DGK1 |
YOR311C |
Diacylglycerol kinase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HMI1 |
YOL095C |
Mitochondrial inner membrane localized ATP-dependent DNA helicase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ARP10 |
YDR106W |
Component of the dynactin complex |
physical |
3 |
2 |
1 |
Two-hybrid, Two-hybrid, Affinity Capture-Western |
| FAB1 |
YFR019W |
1-phosphatidylinositol-3-phosphate 5-kinase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| TPS2 |
YDR074W |
Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| PAC2 |
YER007W |
Microtubule effector required for tubulin heterodimer formation |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CRN1 |
YLR429W |
Coronin |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| BOI1 |
YBL085W |
Protein involved in polar growth, functionally redundant with Boi2p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| GIS4 |
YML006C |
CAAX box containing protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPL16B |
YNL069C |
Ribosomal 60S subunit protein L16B |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPN12 |
YFR052W |
Subunit of the 19S regulatory particle of the 26S proteasome lid |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LSM3 |
YLR438C-A |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| KIP1 |
YBL063W |
Kinesin-related motor protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NCL1 |
YBL024W |
S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIF2 |
YBR103W |
WD40 repeat-containing subunit of Set3C histone deacetylase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PHO2 |
YDL106C |
Homeobox transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| VPS41 |
YDR080W |
Subunit of the HOPS endocytic tethering complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PLP1 |
YDR183W |
Protein that interacts with CCT (chaperonin containing TCP-1) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| OSW7 |
YFR039C |
Protein involved in outer spore wall assembly |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PAN2 |
YGL094C |
Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OCA5 |
YHL029C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TMA22 |
YJR014W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YET1 |
YKL065C |
Endoplasmic reticulum transmembrane protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MNR2 |
YKL064W |
Vacuolar membrane protein required for magnesium homeostasis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MDM35 |
YKL053C-A |
Mitochondrial intermembrane space protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| RPS25B |
YLR333C |
Protein component of the small (40S) ribosomal subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MDM30 |
YLR368W |
F-box component of an SCF ubiquitin protein ligase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SNU66 |
YOR308C |
Component of the U4/U6.U5 snRNP complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SFG1 |
YOR315W |
Nuclear protein putative transcription factor |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
2 |
1 |
2 |
Positive Genetic, Positive Genetic |
| AIM39 |
YOL053W |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CIS1 |
YLR346C |
Protein of unknown function found in mitochondria |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Synthetic Growth Defect |
| HRR25 |
YPL204W |
Conserved casein kinase, monopolin subunit |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| COF1 |
YLL050C |
Cofilin, involved in pH-dependent actin filament depolarization |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ERG6 |
YML008C |
Delta(24)-sterol C-methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
physical |
2 |
1 |
1 |
Two-hybrid, Two-hybrid |
| TRM3 |
YDL112W |
2'-O-ribose methyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| SPE1 |
YKL184W |
Ornithine decarboxylase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TMA19 |
YKL056C |
Protein that associates with ribosomes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RFU1 |
YLR073C |
Protein that inhibits Doa4p deubiquitinating activity |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TML25 |
YLR118C |
Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| OCA2 |
YNL056W |
Protein of unknown function |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| TLG2 |
YOL018C |
Syntaxin-like t-SNARE |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| LGE1 |
YPL055C |
Protein involved in histone H2B ubiquitination |
genetic |
2 |
1 |
1 |
Positive Genetic, Positive Genetic |
| OPI3 |
YJR073C |
Methylene-fatty-acyl-phospholipid synthase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RIC1 |
YLR039C |
Protein involved in retrograde transport to the cis-Golgi network |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| LSM7 |
YNL147W |
Lsm (Like Sm) protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AOS1 |
YPR180W |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BDF1 |
YLR399C |
BET family transcriptional regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATP11 |
YNL315C |
Molecular chaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BUD31 |
YCR063W |
Component of the SF3b subcomplex of the U2 snRNP |
genetic |
1 |
1 |
1 |
Positive Genetic |
| AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP1 |
YOL149W |
Subunit of the Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EMP24 |
YGL200C |
Component of the p24 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GTR2 |
YGR163W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AEP2 |
YMR282C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IRR1 |
YIL026C |
Subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| IMG1 |
YCR046C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IMG2 |
YCR071C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG18 |
YFR021W |
Phosphoinositide binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCT2 |
YIL142W |
Subunit beta of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAM1 |
YPL048W |
One of two isoforms of the gamma subunit of eEF1B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FIN1 |
YDR130C |
Spindle pole body-related intermediate filament protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| CSR2 |
YPR030W |
Nuclear ubiquitin protein ligase binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APM3 |
YBR288C |
Mu3-like subunit of the clathrin associated protein complex (AP-3) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CAT5 |
YOR125C |
Protein required for ubiquinone (Coenzyme Q) biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FHL1 |
YPR104C |
Regulator of ribosomal protein (RP) transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EST1 |
YLR233C |
TLC1 RNA-associated factor involved in telomere length regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EAP1 |
YKL204W |
eIF4E-associated protein, competes with eIF4G for binding to eIF4E |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSC1 |
YLR241W |
Calcium permeable gated cation channel |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EXO70 |
YJL085W |
Subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNA5 |
YLR231C |
Kynureninase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ATP20 |
YPR020W |
Subunit g of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IPK1 |
YDR315C |
Inositol 1,3,4,5,6-pentakisphosphate 2-kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ELP6 |
YMR312W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELP4 |
YPL101W |
Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DOC1 |
YGL240W |
Processivity factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE5 |
YNR051C |
Ubiquitin protease cofactor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HPC2 |
YBR215W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FIG4 |
YNL325C |
Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| JNM1 |
YMR294W |
Component of the yeast dynactin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
physical |
1 |
1 |
1 |
Two-hybrid |
| MDM36 |
YPR083W |
Mitochondrial protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RPN5 |
YDL147W |
Subunit of the CSN and 26S proteasome lid complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
physical |
1 |
1 |
1 |
Two-hybrid |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
physical |
1 |
1 |
1 |
Two-hybrid |
| SNX41 |
YDR425W |
Sorting nexin |
physical |
1 |
1 |
1 |
Two-hybrid |
| NST1 |
YNL091W |
Translational inhibitor and suppressor of proteasome-assembly defects |
physical |
1 |
1 |
1 |
Two-hybrid |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
physical |
1 |
1 |
1 |
Two-hybrid |
| NCA2 |
YPR155C |
Protein that regulates expression of Fo-F1 ATP synthase subunits |
physical |
1 |
1 |
1 |
Two-hybrid |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LAM4 |
YHR080C |
Sterol-binding protein that localizes to puncta in the cortical ER |
physical |
1 |
1 |
1 |
Two-hybrid |
| MDM1 |
YML104C |
PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs |
physical |
1 |
1 |
1 |
Two-hybrid |
| MPD2 |
YOL088C |
Member of the protein disulfide isomerase (PDI) family |
physical |
1 |
1 |
1 |
Two-hybrid |
| UBP2 |
YOR124C |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Two-hybrid |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SGF29 |
YCL010C |
Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RRP6 |
YOR001W |
Nuclear exosome exonuclease component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| STT4 |
YLR305C |
Phosphatidylinositol-4-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPA34 |
YJL148W |
RNA polymerase I subunit A34.5 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RCY1 |
YJL204C |
F-box protein involved in recycling endocytosed proteins |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS16A |
YMR143W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TDA1 |
YMR291W |
Protein kinase of unknown cellular role |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YMR295C |
YMR295C |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRC1 |
YMR297W |
Vacuolar carboxypeptidase Y (proteinase C, CPY) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS19B |
YNL302C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL20A |
YMR242C |
Ribosomal 60S subunit protein L20A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRPL33 |
YMR286W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NGL2 |
YMR285C |
Protein involved in 5.8S rRNA processing |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MGS1 |
YNL218W |
Protein with DNA-dependent ATPase and ssDNA annealing activities |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SHE4 |
YOR035C |
Protein containing a UCS (UNC-45/CRO1/SHE4) domain |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TUM1 |
YOR251C |
Rhodanese domain sulfur transferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PFA4 |
YOL003C |
Palmitoyltransferase with autoacylation activity |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS24A |
YER074W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC28 |
YIL076W |
Epsilon-COP subunit of the coatomer |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| QDR2 |
YIL121W |
Plasma membrane transporter of the major facilitator superfamily |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TCD1 |
YHR003C |
tRNA threonylcarbamoyladenosine dehydratase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MGA1 |
YGR249W |
Protein similar to heat shock transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YGR237C |
YGR237C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MTG1 |
YMR097C |
Putative GTPase peripheral to the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LPD1 |
YFL018C |
Dihydrolipoamide dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MEH1 |
YKR007W |
Subunit of the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL2A |
YFR031C-A |
Ribosomal 60S subunit protein L2A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YPK1 |
YKL126W |
S/T protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| OCT1 |
YKL134C |
Mitochondrial intermediate peptidase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS21A |
YKR057W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SDH1 |
YKL148C |
Flavoprotein subunit of succinate dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TOP3 |
YLR234W |
DNA Topoisomerase III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MCR1 |
YKL150W |
Mitochondrial NADH-cytochrome b5 reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS27A |
YKL156W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LIP2 |
YLR239C |
Lipoyl ligase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TPO5 |
YKL174C |
Protein involved in excretion of putrescine and spermidine |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PDR3 |
YBL005W |
Transcriptional activator of the pleiotropic drug resistance network |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PIM1 |
YBL022C |
ATP-dependent Lon protease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRPL36 |
YBR122C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LDB16 |
YCL005W |
Protein involved in lipid droplet (LD) assembly |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL35B |
YDL136W |
Ribosomal 60S subunit protein L35B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRPL7 |
YDR237W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PMP3 |
YDR276C |
Small plasma membrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL12B |
YDR418W |
Ribosomal 60S subunit protein L12B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRO1 |
YDR300C |
Gamma-glutamyl kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MRPL28 |
YDR462W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YGL081W |
YGL081W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| VPS73 |
YGL104C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPS2 |
YDR522C |
Protein expressed during sporulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MET13 |
YGL125W |
Major isozyme of methylenetetrahydrofolate reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PMC1 |
YGL006W |
Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL9A |
YGL147C |
Ribosomal 60S subunit protein L9A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RCK1 |
YGL158W |
Protein kinase involved in oxidative stress response |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UBR1 |
YGR184C |
E3 ubiquitin ligase (N-recognin) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YIA6 |
YIL006W |
Mitochondrial NAD+ transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF8 |
YML114C |
TFIID subunit (65 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LRE1 |
YCL051W |
Protein involved in control of cell wall structure and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL17B |
YJL177W |
Ribosomal 60S subunit protein L17B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNS1 |
YJR131W |
Alpha-1,2-mannosidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL36A |
YMR194W |
Ribosomal 60S subunit protein L36A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR196W |
YMR196W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA1 |
YNL099C |
Putative protein tyrosine phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET22 |
YOL064C |
Bisphosphate-3'-nucleotidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFM1 |
YOR279C |
Component of the Sum1p-Rfm1p-Hst1p complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE3 |
YPR069C |
Spermidine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QCR2 |
YPR191W |
Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC3 |
YAL011W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAC11 |
YDR488C |
Dynein intermediate chain, microtubule motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PCP1 |
YGR101W |
Mitochondrial serine protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KTI12 |
YKL110C |
Protein that plays a role in modification of tRNA wobble nucleosides |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMD8 |
YML038C |
Putative nucleotide sugar transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TAF1 |
YGR274C |
TFIID subunit, involved in RNA pol II transcription initiation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TPK3 |
YKL166C |
cAMP-dependent protein kinase catalytic subunit |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TEM1 |
YML064C |
GTPase involved in initiation of Mitotic Exit Network (MEN) |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPB10 |
YOR210W |
RNA polymerase subunit ABC10-beta |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRS6 |
YOR370C |
Rab escort protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| OMS1 |
YDR316W |
Protein integral to the mitochondrial membrane |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRM2 |
YGL136C |
Mitochondrial 2' O-ribose methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RUD3 |
YOR216C |
Golgi matrix protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCB2 |
YDR397C |
Subunit of a heterodimeric NC2 transcription regulator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPI1 |
YFR003C |
Regulatory subunit of the type I protein phosphatase (PP1) Glc7p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OLE1 |
YGL055W |
Delta(9) fatty acid desaturase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL28 |
YGL103W |
Ribosomal 60S subunit protein L28 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SUA5 |
YGL169W |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VHT1 |
YGR065C |
High-affinity plasma membrane H+-biotin (vitamin H) symporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THS1 |
YIL078W |
Threonyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP25 |
YIL091C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAO3 |
YIL129C |
Component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SQT1 |
YIR012W |
Specific assembly chaperone for ribosomal protein Rpl10p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIM54 |
YJL054W |
Component of the mitochondrial TIM22 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URB2 |
YJR041C |
Protein required for normal metabolism of the rRNA primary transcript |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP2 |
YNR011C |
RNA-dependent DExD/H-box ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| WRS1 |
YOL097C |
Cytoplasmic tryptophanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF5 |
YBR198C |
Subunit (90 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRR1 |
YCL059C |
Nucleolar protein required for rRNA synthesis and ribosomal assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SYF1 |
YDR416W |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSP5 |
YER125W |
NEDD4 family E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAD1 |
YFR005C |
Conserved zinc-finger domain protein involved in pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP18 |
YGR006W |
Splicing factor and component of snRNP U5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MES1 |
YGR264C |
Methionyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC97 |
YHR172W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF4 |
YMR005W |
TFIID subunit (48 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTH2 |
YBL057C |
One of two mitochondrially-localized peptidyl-tRNA hydrolases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RVS167 |
YDR388W |
Calmodulin-binding actin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RML2 |
YEL050C |
Mitochondrial ribosomal protein of the large subunit (L2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YER079W |
YER079W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL159W |
YGL159W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNT3 |
YIL014W |
Alpha-1,3-mannosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL34B |
YIL052C |
Ribosomal 60S subunit protein L34B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PML39 |
YML107C |
Protein required for nuclear retention of unspliced pre-mRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNF5 |
YBR289W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA6 |
YDR067C |
Cytoplasmic protein required for replication of Brome mosaic virus |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDR444W |
YDR444W |
Putative hydrolase acting on ester bonds |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUP1 |
YGR055W |
High affinity methionine permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT102 |
YGR275W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIM4 |
YHL024W |
Putative RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TDA4 |
YJR116W |
Protein distantly similar to ceramide synthases, Lag1p and Lac1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFG1 |
YLR042C |
Cell wall protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL31B |
YLR406C |
Ribosomal 60S subunit protein L31B |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPE2 |
YOL052C |
S-adenosylmethionine decarboxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OYE3 |
YPL171C |
Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAC7 |
YNL054W |
Integral vacuolar membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLA2 |
YNL243W |
Adaptor protein that links actin to clathrin and endocytosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSB3 |
YNL293W |
Rab GTPase-activating protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRP8 |
YHR165C |
Component of U4/U6-U5 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAP42 |
YMR028W |
Essential protein involved in the TOR signaling pathway |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATC1 |
YDR184C |
Nuclear protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FUS1 |
YCL027W |
Membrane protein localized to the shmoo tip |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ALG5 |
YPL227C |
UDP-glucose:dolichyl-phosphate glucosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BET4 |
YJL031C |
Alpha subunit of Type II geranylgeranyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ECM21 |
YBL101C |
Alpha-arrestin, ubiquitin ligase adaptor for Rsp5p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HLR1 |
YDR528W |
Protein involved in regulation of cell wall composition and integrity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CFD1 |
YIL003W |
Highly conserved iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ACB1 |
YGR037C |
Acyl-CoA-binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IRC3 |
YDR332W |
Double-stranded DNA-dependent helicase of the DExH/D-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| IMP21 |
YIL154C |
Transcriptional activator involved in maintenance of ion homeostasis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLO11 |
YIR019C |
GPI-anchored cell surface glycoprotein (flocculin) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GEM1 |
YAL048C |
Outer mitochondrial membrane GTPase, subunit of the ERMES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DOS2 |
YDR068W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AVT3 |
YKL146W |
Vacuolar transporter |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DEG1 |
YFL001W |
tRNA:pseudouridine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ICS2 |
YBR157C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC50 |
YCR094W |
Endosomal protein that interacts with phospholipid flippase Drs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GUT2 |
YIL155C |
Mitochondrial glycerol-3-phosphate dehydrogenase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GOT1 |
YMR292W |
Homodimeric protein that is packaged into COPII vesicles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HER2 |
YMR293C |
Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AVL9 |
YLR114C |
Conserved protein involved in exocytic transport from the Golgi |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALK1 |
YGL021W |
Atypical protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COX12 |
YLR038C |
Subunit VIb of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CBP4 |
YGR174C |
Mitochondrial protein required for assembly of cytochrome bc1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CHM7 |
YJL049W |
Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum |
physical |
1 |
1 |
1 |
Two-hybrid |
| AGP1 |
YCL025C |
Broad-specificity, low-affinity amino acid permease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FEN2 |
YCR028C |
Plasma membrane H+-pantothenate symporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EXO5 |
YBR163W |
Mitochondrial 5'-3' exonuclease and sliding exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DBR1 |
YKL149C |
RNA lariat debranching enzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAX4 |
YGR036C |
Dolichyl pyrophosphate (Dol-P-P) phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
