| ULP2 |
YIL031W |
Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins |
genetic |
11 |
3 |
6 |
Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
| PSE1 |
YMR308C |
Karyopherin/importin that interacts with the nuclear pore complex |
physical |
10 |
4 |
7 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
physical |
9 |
6 |
7 |
Co-crystal Structure, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Protein-peptide |
| SRP1 |
YNL189W |
Karyopherin alpha homolog |
physical |
9 |
5 |
7 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-MS, Reconstituted Complex, Co-crystal Structure |
| KAP95 |
YLR347C |
Karyopherin beta |
physical |
6 |
3 |
6 |
Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
6 |
3 |
5 |
Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Dosage Rescue |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
genetic |
5 |
4 |
4 |
Dosage Rescue, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
4 |
3 |
3 |
Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect |
| SRS2 |
YJL092W |
DNA helicase and DNA-dependent ATPase |
genetic |
4 |
3 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| RAD27 |
YKL113C |
5' to 3' exonuclease, 5' flap endonuclease |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue |
| WSS1 |
YHR134W |
SUMO-ligase and SUMO-targeted metalloprotease |
genetic |
4 |
3 |
2 |
Synthetic Lethality, Dosage Rescue, Synthetic Rescue, Dosage Rescue |
| RAD51 |
YER095W |
Strand exchange protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality |
| RAD50 |
YNL250W |
Subunit of MRX complex with Mre11p and Xrs2p |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| MRE11 |
YMR224C |
Nuclease subunit of the MRX complex with Rad50p and Xrs2p |
genetic |
3 |
1 |
3 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality |
| RAD52 |
YML032C |
Protein involved in homologous recombination |
genetic |
3 |
3 |
2 |
Synthetic Lethality, Synthetic Growth Defect, Dosage Rescue |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
3 |
3 |
2 |
Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement |
| MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
physical |
3 |
2 |
2 |
Two-hybrid, Two-hybrid, Affinity Capture-MS |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
3 |
2 |
2 |
Dosage Rescue, Negative Genetic, Negative Genetic |
| HDA1 |
YNL021W |
Catalytic subunit of class II HDA1 histone deacetylase complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SLX1 |
YBR228W |
Endonuclease involved in DNA recombination and repair |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| UBC4 |
YBR082C |
Ubiquitin-conjugating enzyme (E2) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MMS22 |
YLR320W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| ESC2 |
YDR363W |
Sumo-like domain protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MMS21 |
YEL019C |
Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
2 |
2 |
2 |
Affinity Capture-RNA, Affinity Capture-MS |
| RAD54 |
YGL163C |
DNA-dependent ATPase that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| RAD55 |
YDR076W |
Protein that stimulates strand exchange |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| GPP2 |
YER062C |
DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
genetic |
2 |
2 |
2 |
Dosage Rescue, Negative Genetic |
| LEU1 |
YGL009C |
Isopropylmalate isomerase |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
| GRX3 |
YDR098C |
Glutathione-dependent oxidoreductase |
physical |
2 |
2 |
2 |
PCA, Affinity Capture-MS |
| NOP12 |
YOL041C |
Nucleolar protein involved in pre-25S rRNA processing |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MOT1 |
YPL082C |
Essential protein involved in regulation of transcription |
genetic |
2 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue |
| HOS2 |
YGL194C |
Histone deacetylase and subunit of Set3 and Rpd3L complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UPS1 |
YLR193C |
Phosphatidic acid transfer protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MGR3 |
YMR115W |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| COQ2 |
YNR041C |
Para hydroxybenzoate polyprenyl transferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MMM1 |
YLL006W |
ER integral membrane protein, ERMES complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OAR1 |
YKL055C |
Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MSC6 |
YOR354C |
Multicopy suppressor of HER2 involved in mitochondrial translation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Synthetic Growth Defect |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
2 |
2 |
1 |
Positive Genetic, Negative Genetic |
| GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Two-hybrid |
| NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
2 |
2 |
1 |
Affinity Capture-Western, Reconstituted Complex |
| ESC1 |
YMR219W |
Protein involved in telomeric silencing |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Enhancement |
| TDP1 |
YBR223C |
Tyrosyl-DNA phosphodiesterase I |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Dosage Rescue |
| NSE1 |
YLR007W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSE3 |
YDR288W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC48 |
YDL126C |
AAA ATPase with protein-unfoldase activity |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| DNA2 |
YHR164C |
ATP-dependent 5'-flap endonuclease and DNA helicase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| RFC5 |
YBR087W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SET2 |
YJL168C |
Histone methyltransferase with a role in transcriptional elongation |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SWD1 |
YAR003W |
Subunit of the COMPASS (Set1C) complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| UBC9 |
YDL064W |
SUMO-conjugating enzyme involved in the Smt3p conjugation pathway |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| RTT109 |
YLL002W |
Histone acetyltransferase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
| INO1 |
YJL153C |
Inositol-3-phosphate synthase |
regulation |
1 |
1 |
1 |
quantitative reverse transcription polymerase chain reaction evidence |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
regulation |
1 |
1 |
1 |
qualitative western immunoblotting evidence |
| CDC73 |
YLR418C |
Component of the Paf1p complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CWC25 |
YNL245C |
Splicing factor required for the first step of pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POB3 |
YML069W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKB2 |
YOR039W |
Beta' regulatory subunit of casein kinase 2 (CK2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
physical |
1 |
1 |
1 |
PCA |
| ARP4 |
YJL081C |
Nuclear actin-related protein involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWC4 |
YGR002C |
Component of the Swr1p complex that incorporates Htz1p into chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HAS1 |
YMR290C |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRP19 |
YLL036C |
Splicing factor associated with the spliceosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POP3 |
YNL282W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE29 |
YER038C |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
physical |
1 |
1 |
1 |
PCA |
| NHP2 |
YDL208W |
Protein related to mammalian high mobility group (HMG) proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAT1 |
YCR077C |
Deadenylation-dependent mRNA-decapping factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPC40 |
YPR110C |
RNA polymerase subunit AC40 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPC19 |
YNL113W |
RNA polymerase subunit AC19 |
physical |
1 |
1 |
1 |
PCA |
| RPC25 |
YKL144C |
RNA polymerase III subunit C25 |
physical |
1 |
1 |
1 |
PCA |
| RPC34 |
YNR003C |
RNA polymerase III subunit C34 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPN2 |
YIL075C |
Subunit of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPN9 |
YDR427W |
Non-ATPase regulatory subunit of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UBP6 |
YFR010W |
Ubiquitin-specific protease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NIP1 |
YMR309C |
eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRT1 |
YOR361C |
eIF3b subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| AAH1 |
YNL141W |
Adenine deaminase (adenine aminohydrolase) |
physical |
1 |
1 |
1 |
PCA |
| BCP1 |
YDR361C |
Essential nuclear chaperone for ribosomal protein Rpl23p |
physical |
1 |
1 |
1 |
PCA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUS1 |
YPL212C |
tRNA:pseudouridine synthase |
physical |
1 |
1 |
1 |
PCA |
| THS1 |
YIL078W |
Threonyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSR2 |
YLR435W |
Protein with a potential role in pre-rRNA processing |
physical |
1 |
1 |
1 |
PCA |
| APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APL1 |
YJR005W |
Beta-adaptin |
physical |
1 |
1 |
1 |
PCA |
| ARC35 |
YNR035C |
Subunit of the ARP2/3 complex |
physical |
1 |
1 |
1 |
PCA |
| ARO1 |
YDR127W |
Pentafunctional arom protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASF1 |
YJL115W |
Nucleosome assembly factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CAR1 |
YPL111W |
Arginase, catabolizes arginine to ornithine and urea |
physical |
1 |
1 |
1 |
PCA |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
1 |
1 |
1 |
PCA |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
1 |
1 |
1 |
PCA |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
physical |
1 |
1 |
1 |
PCA |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COX5A |
YNL052W |
Subunit Va of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CPR1 |
YDR155C |
Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
1 |
1 |
1 |
PCA |
| CYR1 |
YJL005W |
Adenylate cyclase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCP1 |
YOL149W |
Subunit of the Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DCP2 |
YNL118C |
Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CIA2 |
YHR122W |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DPB3 |
YBR278W |
Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENO1 |
YGR254W |
Enolase I, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
PCA |
| ERG13 |
YML126C |
3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase |
physical |
1 |
1 |
1 |
PCA |
| FIP1 |
YJR093C |
Subunit of cleavage polyadenylation factor (CPF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FRS1 |
YLR060W |
Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GGA2 |
YHR108W |
Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HHF1 |
YBR009C |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| AEP1 |
YMR064W |
Protein required for expression of the mitochondrial OLI1 gene |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AEP2 |
YMR282C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHF2 |
YNL030W |
Histone H4 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| IPP1 |
YBR011C |
Cytoplasmic inorganic pyrophosphatase (PPase) |
physical |
1 |
1 |
1 |
PCA |
| KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
| KRR1 |
YCL059C |
Nucleolar protein required for rRNA synthesis and ribosomal assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FAP7 |
YDL166C |
Essential NTPase required for small ribosome subunit synthesis |
physical |
1 |
1 |
1 |
PCA |
| CRM1 |
YGR218W |
Nuclear export factor, exportin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ENO2 |
YHR174W |
Enolase II, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
PCA |
| CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| FBA1 |
YKL060C |
Fructose 1,6-bisphosphate aldolase |
physical |
1 |
1 |
1 |
PCA |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
PCA |
| MRM1 |
YOR201C |
Ribose methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL1 |
YDR116C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MRPL25 |
YGR076C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
physical |
1 |
1 |
1 |
Two-hybrid |
| MIS1 |
YBR084W |
Mitochondrial C1-tetrahydrofolate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NHP6B |
YBR089C-A |
High-mobility group (HMG) protein |
physical |
1 |
1 |
1 |
PCA |
| FPR4 |
YLR449W |
Peptidyl-prolyl cis-trans isomerase (PPIase) |
physical |
1 |
1 |
1 |
PCA |
| NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AHA1 |
YDR214W |
Co-chaperone that binds Hsp82p and activates its ATPase activity |
physical |
1 |
1 |
1 |
PCA |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDB1 |
YBR221C |
E1 beta subunit of the pyruvate dehydrogenase (PDH) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PGK1 |
YCR012W |
3-phosphoglycerate kinase |
physical |
1 |
1 |
1 |
PCA |
| BLM10 |
YFL007W |
Proteasome activator |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GLE2 |
YER107C |
RNA export factor associated with the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NRP1 |
YDL167C |
Putative RNA binding protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PUB1 |
YNL016W |
Poly (A)+ RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GPM1 |
YKL152C |
Tetrameric phosphoglycerate mutase |
physical |
1 |
1 |
1 |
PCA |
| PTI1 |
YGR156W |
Essential component of CPF (cleavage and polyadenylation factor) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFA1 |
YAR007C |
Subunit of heterotrimeric Replication Protein A (RPA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC2 |
YJR068W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFC1 |
YOR217W |
Subunit of heteropentameric Replication factor C (RF-C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
physical |
1 |
1 |
1 |
PCA |
| RPB8 |
YOR224C |
RNA polymerase subunit ABC14.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RCO1 |
YMR075W |
Essential component of the Rpd3S histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIL1 |
YGR086C |
Eisosome core component |
physical |
1 |
1 |
1 |
PCA |
| REA1 |
YLR106C |
Huge dynein-related AAA-type ATPase (midasin) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| NUP145 |
YGL092W |
Essential protein with distinct roles in two nuclear pore subcomplexes |
physical |
1 |
1 |
1 |
PCA |
| SEC21 |
YNL287W |
Gamma subunit of coatomer |
physical |
1 |
1 |
1 |
PCA |
| RPP2B |
YDR382W |
Ribosomal protein P2 beta |
physical |
1 |
1 |
1 |
PCA |
| SER3 |
YER081W |
3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SLC1 |
YDL052C |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PRP9 |
YDL030W |
Subunit of the SF3a splicing factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMD1 |
YGR074W |
Core Sm protein Sm D1 |
physical |
1 |
1 |
1 |
PCA |
| NAT1 |
YDL040C |
Subunit of protein N-terminal acetyltransferase NatA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF10 |
YDR167W |
Subunit (145 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF11 |
YML015C |
TFIID subunit (40 kDa) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPD3 |
YAL016W |
Regulatory subunit A of the heterotrimeric PP2A complex |
physical |
1 |
1 |
1 |
PCA |
| BCY1 |
YIL033C |
Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TPS1 |
YBR126C |
Synthase subunit of trehalose-6-P synthase/phosphatase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TRP2 |
YER090W |
Anthranilate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SDC1 |
YDR469W |
Subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP12 |
YPL012W |
Protein required for export of the ribosomal subunits |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| DIA4 |
YHR011W |
Probable mitochondrial seryl-tRNA synthetase |
physical |
1 |
1 |
1 |
Two-hybrid |
| GET4 |
YOR164C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FPR3 |
YML074C |
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) |
physical |
1 |
1 |
1 |
PCA |
| EGD2 |
YHR193C |
Alpha subunit of the nascent polypeptide-associated complex (NAC) |
physical |
1 |
1 |
1 |
PCA |
| CAR2 |
YLR438W |
L-ornithine transaminase (OTAse) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| BBC1 |
YJL020C |
Protein possibly involved in assembly of actin patches |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GND1 |
YHR183W |
6-phosphogluconate dehydrogenase (decarboxylating) |
physical |
1 |
1 |
1 |
PCA |
| PYC1 |
YGL062W |
Pyruvate carboxylase isoform |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PYC1 |
YGL062W |
Pyruvate carboxylase isoform |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADO1 |
YJR105W |
Adenosine kinase |
physical |
1 |
1 |
1 |
PCA |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ATG29 |
YPL166W |
Autophagy-specific protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPP1 |
YIL053W |
Constitutively expressed DL-glycerol-3-phosphate phosphatase |
physical |
1 |
1 |
1 |
PCA |
| CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
physical |
1 |
1 |
1 |
PCA |
| AHP1 |
YLR109W |
Thiol-specific peroxiredoxin |
physical |
1 |
1 |
1 |
PCA |
| ARO4 |
YBR249C |
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
physical |
1 |
1 |
1 |
PCA |
| POR1 |
YNL055C |
Mitochondrial porin (voltage-dependent anion channel) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
physical |
1 |
1 |
1 |
PCA |
| ESL2 |
YKR096W |
hEST1A/B (SMG5/6)-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| EGD1 |
YPL037C |
Subunit beta1 of the nascent polypeptide-associated complex (NAC) |
physical |
1 |
1 |
1 |
PCA |
| CDC9 |
YDL164C |
DNA ligase I found in nucleus and mitochondria |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADK1 |
YDR226W |
Adenylate kinase, required for purine metabolism |
physical |
1 |
1 |
1 |
PCA |
| COF1 |
YLL050C |
Cofilin, involved in pH-dependent actin filament depolarization |
physical |
1 |
1 |
1 |
PCA |
| TOP2 |
YNL088W |
Topoisomerase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEF3 |
YNL014W |
Translational elongation factor EF-3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| LIA1 |
YJR070C |
Deoxyhypusine hydroxylase |
physical |
1 |
1 |
1 |
PCA |
| MAE1 |
YKL029C |
Mitochondrial malic enzyme |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| APT1 |
YML022W |
Adenine phosphoribosyltransferase |
physical |
1 |
1 |
1 |
PCA |
| ACS2 |
YLR153C |
Acetyl-coA synthetase isoform |
physical |
1 |
1 |
1 |
PCA |
| ERG10 |
YPL028W |
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) |
physical |
1 |
1 |
1 |
PCA |
| RNQ1 |
YCL028W |
[PIN(+)] prion |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CAT5 |
YOR125C |
Protein required for ubiquinone (Coenzyme Q) biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ETP1 |
YHL010C |
Protein of unknown function required for growth on ethanol |
physical |
1 |
1 |
1 |
Two-hybrid |
| GRS1 |
YBR121C |
Cytoplasmic and mitochondrial glycyl-tRNA synthase |
physical |
1 |
1 |
1 |
PCA |
| RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
physical |
1 |
1 |
1 |
Two-hybrid |
| RAD18 |
YCR066W |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MET6 |
YER091C |
Cobalamin-independent methionine synthase |
physical |
1 |
1 |
1 |
PCA |
| CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRR1 |
YDR353W |
Cytoplasmic thioredoxin reductase |
physical |
1 |
1 |
1 |
PCA |
| TMA19 |
YKL056C |
Protein that associates with ribosomes |
physical |
1 |
1 |
1 |
PCA |
| TMA19 |
YKL056C |
Protein that associates with ribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRI1 |
YNL308C |
Essential nucleolar protein required for 40S ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KIN2 |
YLR096W |
S/T protein kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHT1 |
YBR010W |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LHS1 |
YKL073W |
Molecular chaperone of the endoplasmic reticulum lumen |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| SIS1 |
YNL007C |
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p |
physical |
1 |
1 |
1 |
PCA |
| SHS1 |
YDL225W |
Component of the septin ring that is required for cytokinesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCE1 |
YKL011C |
Mitochondrial cruciform cutting endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RGI1 |
YER067W |
Protein involved in energy metabolism under respiratory conditions |
physical |
1 |
1 |
1 |
PCA |
| MSS116 |
YDR194C |
Mitochondrial transcription elongation factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUP2 |
YLR335W |
Nucleoporin involved in nucleocytoplasmic transport |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APA1 |
YCL050C |
AP4A phosphorylase |
physical |
1 |
1 |
1 |
PCA |
| UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
physical |
1 |
1 |
1 |
PCA |
| DEF1 |
YKL054C |
RNAPII degradation factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MMS4 |
YBR098W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FCF1 |
YDR339C |
PINc domain endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDJ1 |
YFL016C |
Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ADH6 |
YMR318C |
NADPH-dependent medium chain alcohol dehydrogenase |
physical |
1 |
1 |
1 |
PCA |
| CYS3 |
YAL012W |
Cystathionine gamma-lyase |
physical |
1 |
1 |
1 |
PCA |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
physical |
1 |
1 |
1 |
PCA |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PEX29 |
YDR479C |
ER-resident protein involved in peroxisomal biogenesis |
physical |
1 |
1 |
1 |
Two-hybrid |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NDL1 |
YLR254C |
Homolog of nuclear distribution factor NudE |
physical |
1 |
1 |
1 |
Two-hybrid |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLU7 |
YDR088C |
RNA splicing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TOP1 |
YOL006C |
Topoisomerase I |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TVP18 |
YMR071C |
Integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| RBD2 |
YPL246C |
Possible rhomboid protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEX14 |
YGL153W |
Central component of the peroxisomal importomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THG1 |
YGR024C |
tRNAHis guanylyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
PCA |
| TDH2 |
YJR009C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 |
physical |
1 |
1 |
1 |
PCA |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| RLP24 |
YLR009W |
Essential protein required for ribosomal large subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NFI1 |
YOR156C |
SUMO E3 ligase |
physical |
1 |
1 |
1 |
Two-hybrid |
| NFI1 |
YOR156C |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL23B |
YER117W |
Ribosomal 60S subunit protein L23B |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NHP6A |
YPR052C |
High-mobility group (HMG) protein |
physical |
1 |
1 |
1 |
PCA |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCR1 |
YPL075W |
Transcriptional activator of genes involved in glycolysis |
physical |
1 |
1 |
1 |
Two-hybrid |
| MRS1 |
YIR021W |
Splicing protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GCD10 |
YNL062C |
Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HNT1 |
YDL125C |
Adenosine 5'-monophosphoramidase |
physical |
1 |
1 |
1 |
PCA |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MTR2 |
YKL186C |
mRNA transport regulator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SIZ1 |
YDR409W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SIP5 |
YMR140W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSA1 |
YAL005C |
ATPase involved in protein folding and NLS-directed nuclear transport |
physical |
1 |
1 |
1 |
PCA |
| TRX1 |
YLR043C |
Cytoplasmic thioredoxin isoenzyme |
physical |
1 |
1 |
1 |
PCA |
| UBA2 |
YDR390C |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p |
physical |
1 |
1 |
1 |
PCA |
| SMC4 |
YLR086W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC5 |
YDR166C |
Essential 107kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSA2 |
YLL024C |
HSP70 family ATP-binding protein |
physical |
1 |
1 |
1 |
PCA |
| MOB1 |
YIL106W |
Component of the mitotic exit network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRM8 |
YGL053W |
Pheromone-regulated protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC34 |
YKR037C |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
PCA |
| HCH1 |
YNL281W |
Heat shock protein regulator |
physical |
1 |
1 |
1 |
PCA |
| REC107 |
YJR021C |
Protein involved in early stages of meiotic recombination |
physical |
1 |
1 |
1 |
Two-hybrid |
| REC107 |
YJR021C |
Protein involved in early stages of meiotic recombination |
genetic |
1 |
1 |
1 |
Positive Genetic |
| GPR1 |
YDL035C |
Plasma membrane G protein coupled receptor (GPCR) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
physical |
1 |
1 |
1 |
PCA |
| NUP42 |
YDR192C |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| AZF1 |
YOR113W |
Zinc-finger transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNM1 |
YDR478W |
Ribonuclease MRP complex subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAM2 |
YDR502C |
S-adenosylmethionine synthetase |
physical |
1 |
1 |
1 |
PCA |
| RPL1A |
YPL220W |
Ribosomal 60S subunit protein L1A |
physical |
1 |
1 |
1 |
PCA |
| ATP10 |
YLR393W |
Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MNN11 |
YJL183W |
Subunit of a Golgi mannosyltransferase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SHE9 |
YDR393W |
Protein required for normal mitochondrial morphology |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP8 |
YOL144W |
Nucleolar protein required for 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL28 |
YGL103W |
Ribosomal 60S subunit protein L28 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PER33 |
YLR064W |
Protein that localizes to the endoplasmic reticulum |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOG1 |
YJR074W |
Conserved nuclear protein that interacts with GTP-Gsp1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL27B |
YDR471W |
Ribosomal 60S subunit protein L27B |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTR3 |
YFR029W |
Component of the SPS plasma membrane amino acid sensor system |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ATP18 |
YML081C-A |
Subunit of the mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ADE1 |
YAR015W |
N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase |
physical |
1 |
1 |
1 |
PCA |
| MMS1 |
YPR164W |
Subunit of E3 ubiquitin ligase complex involved in replication repair |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ESBP6 |
YNL125C |
Protein with similarity to monocarboxylate permeases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CFD1 |
YIL003W |
Highly conserved iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAM17 |
YKR065C |
Constituent of the TIM23 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRX2 |
YGR209C |
Cytoplasmic thioredoxin isoenzyme |
physical |
1 |
1 |
1 |
PCA |
| DAD3 |
YBR233W-A |
Essential subunit of the Dam1 complex (aka DASH complex) |
physical |
1 |
1 |
1 |
PCA |
| SWD3 |
YBR175W |
Essential subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOL2 |
YCR073W-A |
Protein with a possible role in tRNA export |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP40 |
YKR092C |
Nucleolar serine-rich protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GUK1 |
YDR454C |
Guanylate kinase |
physical |
1 |
1 |
1 |
PCA |
| BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MSS1 |
YMR023C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NOP19 |
YGR251W |
Ribosome biogenesis factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OCA4 |
YCR095C |
Cytoplasmic protein required for replication of Brome mosaic virus |
physical |
1 |
1 |
1 |
PCA |
| GRE3 |
YHR104W |
Aldose reductase |
physical |
1 |
1 |
1 |
PCA |
| IRC8 |
YJL051W |
Bud tip localized protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPP1A |
YDL081C |
Ribosomal stalk protein P1 alpha |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
physical |
1 |
1 |
1 |
PCA |
| SLX4 |
YLR135W |
Endonuclease involved in processing DNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC14 |
YMR079W |
Phosphatidylinositol/phosphatidylcholine transfer protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGR1 |
YCL044C |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GIS2 |
YNL255C |
Translational activator for mRNAs with internal ribosome entry sites |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SHM2 |
YLR058C |
Cytosolic serine hydroxymethyltransferase |
physical |
1 |
1 |
1 |
PCA |
| LEU9 |
YOR108W |
Alpha-isopropylmalate synthase II (2-isopropylmalate synthase) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| GLN4 |
YOR168W |
Glutamine tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NPT1 |
YOR209C |
Nicotinate phosphoribosyltransferase |
physical |
1 |
1 |
1 |
PCA |
| PTH2 |
YBL057C |
One of two mitochondrially-localized peptidyl-tRNA hydrolases |
physical |
1 |
1 |
1 |
PCA |
| SDD2 |
YMR074C |
Protein with homology to human PDCD5 |
physical |
1 |
1 |
1 |
PCA |
| SRP68 |
YPL243W |
Core component of the signal recognition particle (SRP) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ARO3 |
YDR035W |
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase |
physical |
1 |
1 |
1 |
PCA |
| SLM3 |
YDL033C |
tRNA-specific 2-thiouridylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URA2 |
YJL130C |
Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| YCR007C |
YCR007C |
Putative integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| YOL107W |
YOL107W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| YHB1 |
YGR234W |
Nitric oxide oxidoreductase |
physical |
1 |
1 |
1 |
PCA |
| YNL134C |
YNL134C |
NADH-dependent aldehyde reductase |
physical |
1 |
1 |
1 |
PCA |
| YDL124W |
YDL124W |
NADPH-dependent alpha-keto amide reductase |
physical |
1 |
1 |
1 |
PCA |
| URA1 |
YKL216W |
Dihydroorotate dehydrogenase |
physical |
1 |
1 |
1 |
PCA |
| YPR1 |
YDR368W |
NADPH-dependent aldo-keto reductase |
physical |
1 |
1 |
1 |
PCA |
| YMR099C |
YMR099C |
Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase) |
physical |
1 |
1 |
1 |
PCA |
| URA6 |
YKL024C |
Uridylate kinase |
physical |
1 |
1 |
1 |
PCA |
| YBL028C |
YBL028C |
Protein of unknown function that may interact with ribosomes |
physical |
1 |
1 |
1 |
PCA |
| URM1 |
YIL008W |
Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs |
physical |
1 |
1 |
1 |
PCA |
| YPT7 |
YML001W |
Rab family GTPase |
physical |
1 |
1 |
1 |
PCA |
| VPS21 |
YOR089C |
Endosomal Rab family GTPase |
physical |
1 |
1 |
1 |
PCA |
| YMR295C |
YMR295C |
Protein of unknown function that associates with ribosomes |
physical |
1 |
1 |
1 |
PCA |
| YPL225W |
YPL225W |
Protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
| YDL085C-A |
YDL085C-A |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
| YBL005W-B |
YBL005W-B |
Retrotransposon TYA Gag and TYB Pol genes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YHM2 |
YMR241W |
Citrate and oxoglutarate carrier protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YOR019W |
YOR019W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YPR015C |
YPR015C |
Putative zinc finger transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YPR148C |
YPR148C |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YRO2 |
YBR054W |
Protein with a putative role in response to acid stress |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YTA7 |
YGR270W |
Chromatin-binding ATPase that regulates histone gene expression |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| USO1 |
YDL058W |
Essential protein involved in vesicle-mediated ER to Golgi transport |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VTI1 |
YMR197C |
Protein involved in cis-Golgi membrane traffic |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP5 |
YDR398W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP9 |
YHR196W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UTP15 |
YMR093W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGL235W |
YGL235W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UPS2 |
YLR168C |
Mitochondrial intermembrane space protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBL086C |
YBL086C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YBR184W |
YBR184W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VVS1 |
YBR241C |
Putative transporter, member of the sugar porter family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YER039C-A |
YER039C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YIL089W |
YIL089W |
Protein of unknown function found in the ER and vacuole lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YKR070W |
YKR070W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VID22 |
YLR373C |
G-quadruplex (G4) DNA binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YLR412C-A |
YLR412C-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YMR272W-B |
YMR272W-B |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VPS4 |
YPR173C |
AAA-ATPase involved in multivesicular body (MVB) protein sorting |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IDI1 |
YPL117C |
Isopentenyl diphosphate:dimethylallyl diphosphate isomerase |
physical |
1 |
1 |
1 |
PCA |
| IRC5 |
YFR038W |
Putative ATPase containing the DEAD/H helicase-related sequence motif |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| STF2 |
YGR008C |
Protein involved in resistance to desiccation stress |
physical |
1 |
1 |
1 |
PCA |
| TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Two-hybrid |
| UAF30 |
YOR295W |
Subunit of UAF (upstream activation factor) complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PYP1 |
YNL010W |
Sugar alcohol phosphatase |
physical |
1 |
1 |
1 |
PCA |
| EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBX2 |
YML013W |
Bridging factor involved in ER-associated protein degradation (ERAD) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APE4 |
YHR113W |
Cytoplasmic aspartyl aminopeptidase with possible vacuole function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RSF1 |
YMR030W |
Protein required for respiratory growth |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JJJ3 |
YJR097W |
Iron-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RDL1 |
YOR285W |
Thiosulfate sulfurtransferase |
physical |
1 |
1 |
1 |
PCA |
| TVP15 |
YDR100W |
Integral membrane protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| MDM34 |
YGL219C |
Mitochondrial component of the ERMES complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COA1 |
YIL157C |
Mitochondrial inner membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KIP3 |
YGL216W |
Kinesin-related antiparallel sliding motor protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GRX3 |
YDR098C |
Glutathione-dependent oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCS7 |
YMR272C |
Sphingolipid alpha-hydroxylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COS7 |
YDL248W |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRT14 |
YIL127C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
| SQT1 |
YIR012W |
Specific assembly chaperone for ribosomal protein Rpl10p |
physical |
1 |
1 |
1 |
PCA |
| TPI1 |
YDR050C |
Triose phosphate isomerase, abundant glycolytic enzyme |
physical |
1 |
1 |
1 |
PCA |
| UIP3 |
YAR027W |
Putative integral membrane protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| RMR1 |
YGL250W |
Protein required for meiotic recombination and gene conversion |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHB17 |
YKR043C |
Sedoheptulose bisphosphatase involved in riboneogenesis |
physical |
1 |
1 |
1 |
PCA |
| GRX2 |
YDR513W |
Cytoplasmic glutaredoxin |
physical |
1 |
1 |
1 |
PCA |
| EMI1 |
YDR512C |
Non-essential protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TMA17 |
YDL110C |
Regulatory gamma subunit of fatty acid synthase (FAS) |
physical |
1 |
1 |
1 |
PCA |
| MTO1 |
YGL236C |
Mitochondrial protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TDH3 |
YGR192C |
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 |
physical |
1 |
1 |
1 |
PCA |
| MTC3 |
YGL226W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NCE103 |
YNL036W |
Carbonic anhydrase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| HOR7 |
YMR251W-A |
Protein of unknown function |
physical |
1 |
1 |
1 |
PCA |
| IGO2 |
YHR132W-A |
Protein required for initiation of G0 program |
physical |
1 |
1 |
1 |
PCA |
| CMC2 |
YBL059C-A |
Protein involved in respiratory chain complex assembly or maintenance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MDL2 |
YPL270W |
Mitochondrial inner membrane half-type ABC transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP2 |
YLR239C |
Lipoyl ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FLX1 |
YIL134W |
Mitochondrial flavin adenine dinucleotide transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TIF11 |
YMR260C |
Translation initiation factor eIF1A |
physical |
1 |
1 |
1 |
PCA |
| GCV1 |
YDR019C |
T subunit of the mitochondrial glycine decarboxylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AIM10 |
YER087W |
Protein with similarity to tRNA synthetases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NPR3 |
YHL023C |
Subunit of the Iml1p/SEACIT complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| RPL41A |
YDL184C |
Ribosomal 60S subunit protein L41A |
physical |
1 |
1 |
1 |
PCA |
| MTQ1 |
YNL063W |
S-adenosylmethionine-dependent methyltransferase |
physical |
1 |
1 |
1 |
PCA |
| SER2 |
YGR208W |
Phosphoserine phosphatase of the phosphoglycerate pathway |
physical |
1 |
1 |
1 |
PCA |
| SPR3 |
YGR059W |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
physical |
1 |
1 |
1 |
Two-hybrid |
| TMA10 |
YLR327C |
Protein of unknown function that associates with ribosomes |
physical |
1 |
1 |
1 |
PCA |
| CWP1 |
YKL096W |
Cell wall mannoprotein that localizes to birth scars of daughter cells |
physical |
1 |
1 |
1 |
PCA |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| PET117 |
YER058W |
Assembly factor that couples heme a synthesis to complex IV assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QRI7 |
YDL104C |
Protein involved in threonylcarbamoyl adenosine biosynthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTC6 |
YPL183W-A |
Protein involved in translation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEM4 |
YOR278W |
Uroporphyrinogen III synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THI7 |
YLR237W |
Plasma membrane transporter responsible for the uptake of thiamine |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MIN3 |
YMR182W-A |
Mitochondrial protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
