Standard name Systematic name Name description Description
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex Component of the Mcm2-7 hexameric helicase complex; MCM complex is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase
Visualize the interactome of MCM5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 18

CYCLoPs localization & abundance

WT1 WT2 WT3
no data no data no data

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MCM5 2 0 0 0 4

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MCM3 YEL032W Protein involved in DNA replication physical 23 6 17 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Co-localization, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
CDC45 YLR103C DNA replication initiation factor physical 18 5 15 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-fractionation, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Co-purification, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 16 4 13 Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 15 3 14 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
MCM2 YBL023C Protein involved in DNA replication physical 12 6 12 Affinity Capture-Western, Co-localization, Co-fractionation, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 12 5 11 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex physical 12 5 8 Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Two-hybrid, Co-purification, Affinity Capture-MS, Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 7 5 6 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein physical 7 4 6 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Co-localization, Affinity Capture-Western
MCM2 YBL023C Protein involved in DNA replication genetic 6 4 5 Phenotypic Enhancement, Synthetic Rescue, Dosage Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue
MCM6 YGL201C Protein involved in DNA replication physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-purification, Affinity Capture-MS, Affinity Capture-MS
TAH11 YJR046W DNA replication licensing factor physical 6 2 5 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
MCM3 YEL032W Protein involved in DNA replication genetic 5 4 5 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic
CTF4 YPR135W Chromatin-associated protein physical 5 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 5 2 4 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Negative Genetic, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication physical 5 2 3 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-fractionation, Reconstituted Complex
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 4 4 4 Phenotypic Enhancement, Negative Genetic, Phenotypic Suppression, Synthetic Rescue
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 4 3 4 Reconstituted Complex, Reconstituted Complex, Co-purification, Affinity Capture-Western
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 4 3 3 Dosage Lethality, Dosage Growth Defect, Negative Genetic, Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 4 3 3 Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic, Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 3 3 3 Phenotypic Enhancement, Dosage Growth Defect, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Co-purification
CDC6 YJL194W Essential ATP-binding protein required for DNA replication physical 3 2 3 Co-localization, Co-localization, Affinity Capture-Western
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 3 3 2 Biochemical Activity, Two-hybrid, Affinity Capture-Western
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 3 2 2 Dosage Lethality, Negative Genetic, Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 2 2 2 Co-purification, Affinity Capture-Western
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 2 2 Co-localization, Two-hybrid
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 2 2 Synthetic Lethality, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
CHL1 YPL008W Probable DNA helicase genetic 2 2 2 Dosage Growth Defect, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 2 Negative Genetic, Negative Genetic
PSF3 YOL146W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 2 1 2 Reconstituted Complex, Reconstituted Complex
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 2 1 2 Negative Genetic, Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 2 1 2 Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Negative Genetic, Negative Genetic
SLD2 YKL108W Single-stranded DNA origin-binding and annealing protein physical 2 1 1 Reconstituted Complex, Reconstituted Complex
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 1 1 Negative Genetic, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 1 Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Negative Genetic, Negative Genetic
PDS1 YDR113C Securin genetic 2 1 1 Negative Genetic, Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 2 1 1 Negative Genetic, Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 2 1 1 Negative Genetic, Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 2 1 1 Negative Genetic, Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 1 1 Negative Genetic, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 2 1 1 Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 1 1 Negative Genetic, Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 1 Negative Genetic, Negative Genetic
HTA2 YBL003C Histone H2A physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 1 1 Negative Genetic, Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 1 1 Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 1 1 Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 1 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 1 Negative Genetic, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 2 1 1 Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 1 1 Negative Genetic, Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YOX1 YML027W Homeobox transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Affinity Capture-MS
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Positive Genetic
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 1 1 1 Affinity Capture-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Co-purification
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex physical 1 1 1 Co-purification
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-Western
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Dosage Rescue
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
MLC1 YGL106W Essential light chain for Myo1p physical 1 1 1 Affinity Capture-MS
MYO1 YHR023W Type II myosin heavy chain physical 1 1 1 Affinity Capture-MS
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Positive Genetic
MYO4 YAL029C Type V myosin motor involved in actin-based transport of cargos physical 1 1 1 Affinity Capture-MS
MYO5 YMR109W One of two type I myosin motors physical 1 1 1 Affinity Capture-MS
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Affinity Capture-MS
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Phenotypic Suppression
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 1 1 1 Affinity Capture-MS
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 1 1 1 Affinity Capture-MS
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
TOP2 YNL088W Topoisomerase II physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-MS
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Two-hybrid
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Reconstituted Complex
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
ORC5 YNL261W Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-Western
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Growth Defect
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-Western
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
ORC2 YBR060C Subunit of the origin recognition complex (ORC) physical 1 1 1 Reconstituted Complex
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Co-purification
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Affinity Capture-Western
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-Western
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-Western
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Rescue
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Dosage Rescue
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Phenotypic Suppression
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Positive Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
UTP6 YDR449C Nucleolar protein genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
SFG1 YOR315W Nuclear protein putative transcription factor genetic 1 1 1 Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Negative Genetic
MIX23 YBL107C Mitochondrial intermembrane space protein of unknown function genetic 1 1 1 Negative Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
MIC10 YCL057C-A Conserved component of the MICOS complex genetic 1 1 1 Negative Genetic
POL4 YCR014C DNA polymerase IV genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
PRS2 YER099C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Negative Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
SET4 YJL105W Chromatin-associated protein involved in control of stress response genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
PIR3 YKL163W O-glycosylated covalently-bound cell wall protein genetic 1 1 1 Negative Genetic
TRM2 YKR056W tRNA methyltransferase genetic 1 1 1 Negative Genetic
URA4 YLR420W Dihydroorotase genetic 1 1 1 Negative Genetic
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
MRM1 YOR201C Ribose methyltransferase genetic 1 1 1 Negative Genetic
RFM1 YOR279C Component of the Sum1p-Rfm1p-Hst1p complex genetic 1 1 1 Negative Genetic
YPR159C-A YPR159C-A Protein of unknown function genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Positive Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
PRP8 YHR165C Component of U4/U6-U5 snRNP complex genetic 1 1 1 Positive Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin physical 1 1 1 Affinity Capture-MS
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Negative Genetic
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 1 1 1 Affinity Capture-MS
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Phenotypic Suppression
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Negative Genetic
ESL2 YKR096W hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
CMK1 YFR014C Calmodulin-dependent protein kinase physical 1 1 1 Biochemical Activity
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
BUD32 YGR262C Protein kinase genetic 1 1 1 Dosage Growth Defect
HSL7 YBR133C Protein arginine N-methyltransferase genetic 1 1 1 Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Positive Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network physical 1 1 1 Proximity Label-MS
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein physical 1 1 1 Reconstituted Complex
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Negative Genetic
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis physical 1 1 1 Biochemical Activity
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Affinity Capture-Western
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Phenotypic Suppression
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-Western
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Lethality
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex physical 1 1 1 Reconstituted Complex
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
CDC19 YAL038W Pyruvate kinase physical 1 1 1 Affinity Capture-MS
GYL1 YMR192W Putative GTPase activating protein (GAP) with a role in exocytosis physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
HPA2 YPR193C Tetrameric histone acetyltransferase genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Positive Genetic
DFG16 YOR030W Probable multiple transmembrane protein genetic 1 1 1 Negative Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Positive Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Lethality
CRS5 YOR031W Copper-binding metallothionein genetic 1 1 1 Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Positive Genetic