NPL3 |
YDR432W |
RNA-binding protein |
physical |
15 |
6 |
13 |
Two-hybrid, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Biochemical Activity, PCA, Biochemical Activity, Reconstituted Complex, Biochemical Activity |
HMT1 |
YBR034C |
Nuclear SAM-dependent mono- and asymmetric methyltransferase |
physical |
8 |
6 |
5 |
Co-crystal Structure, Reconstituted Complex, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Reconstituted Complex |
HRP1 |
YOL123W |
Subunit of cleavage factor I |
physical |
6 |
3 |
6 |
Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, PCA |
NPL3 |
YDR432W |
RNA-binding protein |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue |
DBP3 |
YGL078C |
RNA-Dependent ATPase, member of DExD/H-box family |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
STO1 |
YMR125W |
Large subunit of the nuclear mRNA cap-binding protein complex |
genetic |
4 |
2 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic |
CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
4 |
3 |
3 |
Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic |
HHF1 |
YBR009C |
Histone H4 |
physical |
4 |
2 |
3 |
Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Biochemical Activity |
NAB2 |
YGL122C |
Nuclear polyadenylated RNA-binding protein |
physical |
4 |
2 |
3 |
Biochemical Activity, Biochemical Activity, Biochemical Activity, PCA |
MUD2 |
YKL074C |
Protein involved in early pre-mRNA splicing |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
TGS1 |
YPL157W |
Trimethyl guanosine synthase, conserved nucleolar methyl transferase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
MTR10 |
YOR160W |
Nuclear import receptor |
genetic |
4 |
1 |
2 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue |
DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
physical |
4 |
3 |
1 |
Affinity Capture-Western, PCA, PCA, Biochemical Activity |
NOP1 |
YDL014W |
Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus |
physical |
3 |
1 |
3 |
Biochemical Activity, Biochemical Activity, Biochemical Activity |
CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-RNA |
HHF2 |
YNL030W |
Histone H4 |
physical |
3 |
2 |
2 |
Biochemical Activity, Affinity Capture-Western, Biochemical Activity |
YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
physical |
3 |
3 |
1 |
Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity |
SCD6 |
YPR129W |
Repressor of translation initiation |
physical |
3 |
3 |
1 |
Two-hybrid, Affinity Capture-Western, Reconstituted Complex |
PPH22 |
YDL188C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
3 |
2 |
1 |
Affinity Capture-Western, PCA, PCA |
ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
HHT1 |
YBR010W |
Histone H3 |
physical |
2 |
2 |
2 |
Affinity Capture-Western, Biochemical Activity |
BFR1 |
YOR198C |
Component of mRNP complexes associated with polyribosomes |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-RNA |
CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
2 |
2 |
2 |
Positive Genetic, Dosage Growth Defect |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
2 |
2 |
2 |
Biochemical Activity, Affinity Capture-MS |
SNP1 |
YIL061C |
Component of U1 snRNP required for mRNA splicing via spliceosome |
physical |
2 |
2 |
2 |
Two-hybrid, Biochemical Activity |
VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Positive Genetic |
RIM13 |
YMR154C |
Calpain-like cysteine protease |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
RSC2 |
YLR357W |
Component of the RSC chromatin remodeling complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
VPS17 |
YOR132W |
Subunit of the membrane-associated retromer complex |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
GWT1 |
YJL091C |
Protein involved in the inositol acylation of GlcN-PI |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
GAR1 |
YHR089C |
Protein component of the H/ACA snoRNP pseudouridylase complex |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
CDC23 |
YHR166C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
NSR1 |
YGR159C |
Nucleolin, nucleolar protein that binds nuclear localization sequences |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
KCH1 |
YJR054W |
Potassium transporter that mediates K+ influx |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Synthetic Growth Defect |
BRE5 |
YNR051C |
Ubiquitin protease cofactor |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
SSD1 |
YDR293C |
Translational repressor |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
MTR4 |
YJL050W |
RNA duplex-sensing translocase |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Synthetic Growth Defect |
RXT2 |
YBR095C |
Component of the histone deacetylase Rpd3L complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Synthetic Growth Defect |
SAP30 |
YMR263W |
Component of Rpd3L histone deacetylase complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Synthetic Growth Defect |
RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Enhancement |
CDC36 |
YDL165W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
physical |
2 |
1 |
1 |
Affinity Capture-Western, Affinity Capture-Western |
TIM13 |
YGR181W |
Mitochondrial intermembrane space protein |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
MED6 |
YHR058C |
Subunit of the RNA polymerase II mediator complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SEN1 |
YLR430W |
ATP-dependent 5' to 3' RNA/DNA and DNA helicase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SGV1 |
YPR161C |
Cyclin (Bur2p)-dependent protein kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
SFP1 |
YLR403W |
Regulates transcription of ribosomal protein and biogenesis genes |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
SPT20 |
YOL148C |
Subunit of the SAGA transcriptional regulatory complex |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
XBP1 |
YIL101C |
Transcriptional repressor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
SRB5 |
YGR104C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
RPC31 |
YNL151C |
RNA polymerase III subunit C31 |
regulation |
1 |
1 |
1 |
in vitro methylation assay evidence |
ESF1 |
YDR365C |
Nucleolar protein involved in pre-rRNA processing |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DBP9 |
YLR276C |
DEAD-box protein required for 27S rRNA processing |
physical |
1 |
1 |
1 |
PCA |
ARX1 |
YDR101C |
Nuclear export factor for the ribosomal pre-60S subunit |
physical |
1 |
1 |
1 |
PCA |
HCR1 |
YLR192C |
eIF3j component of translation initiation factor 3 (eIF3) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALA1 |
YOR335C |
Cytoplasmic and mitochondrial alanyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC39 |
YCR093W |
Subunit of the CCR4-NOT1 core complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BMS1 |
YPL217C |
GTPase required for ribosomal subunit synthesis and rRNA processing |
genetic |
1 |
1 |
1 |
Negative Genetic |
APC1 |
YNL172W |
Largest subunit of the Anaphase-Promoting Complex/Cyclosome |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARD1 |
YHR013C |
Subunit of protein N-terminal acetyltransferase NatA |
genetic |
1 |
1 |
1 |
Negative Genetic |
BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Negative Genetic |
ASC1 |
YMR116C |
G-protein beta subunit and guanine dissociation inhibitor for Gpa2p |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CAF130 |
YGR134W |
Subunit of the CCR4-NOT transcriptional regulatory complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
1 |
1 |
1 |
Negative Genetic |
BNI1 |
YNL271C |
Formin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
BNI1 |
YNL271C |
Formin |
genetic |
1 |
1 |
1 |
Negative Genetic |
CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
1 |
1 |
1 |
Positive Genetic |
ENO1 |
YGR254W |
Enolase I, a phosphopyruvate hydratase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HIS4 |
YCL030C |
Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ADA2 |
YDR448W |
Transcription coactivator |
genetic |
1 |
1 |
1 |
Negative Genetic |
AFG2 |
YLR397C |
ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
HMO1 |
YDR174W |
Chromatin associated high mobility group (HMG) family member |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DOA4 |
YDR069C |
Ubiquitin hydrolase |
genetic |
1 |
1 |
1 |
Negative Genetic |
DEP1 |
YAL013W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADE3 |
YGR204W |
Cytoplasmic trifunctional enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR1 |
YPR057W |
snRNP protein component of spliceosomal snRNPs |
physical |
1 |
1 |
1 |
Biochemical Activity |
HFI1 |
YPL254W |
Adaptor protein required for structural integrity of the SAGA complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRE2 |
YLR015W |
Subunit of COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DIA4 |
YHR011W |
Probable mitochondrial seryl-tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Negative Genetic |
FPR3 |
YML074C |
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
EGD2 |
YHR193C |
Alpha subunit of the nascent polypeptide-associated complex (NAC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
AKL1 |
YBR059C |
Ser/Thr protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GRR1 |
YJR090C |
F-box protein component of an SCF ubiquitin-ligase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
FDO1 |
YMR144W |
Protein involved in directionality of mating type switching |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
APM3 |
YBR288C |
Mu3-like subunit of the clathrin associated protein complex (AP-3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DUN1 |
YDL101C |
Cell-cycle checkpoint S/T protein kinase |
physical |
1 |
1 |
1 |
PCA |
ARG4 |
YHR018C |
Argininosuccinate lyase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
COS111 |
YBR203W |
Protein required for antifungal drug ciclopirox olamine resistance |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CDC60 |
YPL160W |
Cytosolic leucyl tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GRS1 |
YBR121C |
Cytoplasmic and mitochondrial glycyl-tRNA synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
GLE1 |
YDL207W |
Cytoplasmic nucleoporin required for polyadenylated mRNA export |
physical |
1 |
1 |
1 |
PCA |
CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Negative Genetic |
FRS2 |
YFL022C |
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
CHS1 |
YNL192W |
Chitin synthase I |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
AIR1 |
YIL079C |
Zinc knuckle protein |
physical |
1 |
1 |
1 |
Reconstituted Complex |
CIA1 |
YDR267C |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADE2 |
YOR128C |
Phosphoribosylaminoimidazole carboxylase |
physical |
1 |
1 |
1 |
PCA |
EBS1 |
YDR206W |
Protein involved in translation inhibition and nonsense-mediated decay |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARG81 |
YML099C |
Zinc finger transcription factor involved in arginine-responsive genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
GTR1 |
YML121W |
Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DON1 |
YDR273W |
Meiosis-specific component of the spindle pole body |
physical |
1 |
1 |
1 |
PCA |
CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
physical |
1 |
1 |
1 |
PCA |
ERC1 |
YHR032W |
Member of the multi-drug and toxin extrusion (MATE) family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
FIS1 |
YIL065C |
Protein involved in mitochondrial fission and peroxisome abundance |
genetic |
1 |
1 |
1 |
Positive Genetic |
APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
CDC27 |
YBL084C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
ELP3 |
YPL086C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DOC1 |
YGL240W |
Processivity factor |
physical |
1 |
1 |
1 |
Two-hybrid |
CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Negative Genetic |
ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
DAL81 |
YIR023W |
Positive regulator of genes in multiple nitrogen degradation pathways |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
BDP1 |
YNL039W |
Essential subunit of RNA polymerase III transcription factor (TFIIIB) |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
CSE4 |
YKL049C |
Centromeric histone H3-like protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Positive Genetic |
ELO3 |
YLR372W |
Elongase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EXO1 |
YOR033C |
5'-3' exonuclease and flap-endonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
GCD10 |
YNL062C |
Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p |
physical |
1 |
1 |
1 |
PCA |
GLN3 |
YER040W |
Transcriptional activator in nitrogen catabolite repression system |
genetic |
1 |
1 |
1 |
Negative Genetic |
GAL10 |
YBR019C |
UDP-glucose-4-epimerase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
GYP1 |
YOR070C |
Cis-golgi GTPase-activating protein (GAP) for yeast Rabs |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
LSM8 |
YJR022W |
Lsm (Like Sm) protein |
physical |
1 |
1 |
1 |
Two-hybrid |
HRB1 |
YNL004W |
Poly(A+) RNA-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
NPP2 |
YEL016C |
Nucleotide pyrophosphatase/phosphodiesterase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NKP2 |
YLR315W |
Central kinetochore protein and subunit of the Ctf19 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
genetic |
1 |
1 |
1 |
Positive Genetic |
MRPS35 |
YGR165W |
Mitochondrial ribosomal protein of the small subunit |
physical |
1 |
1 |
1 |
Two-hybrid |
RPN1 |
YHR027C |
Non-ATPase base subunit of the 19S RP of the 26S proteasome |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
1 |
1 |
1 |
Positive Genetic |
TBF1 |
YPL128C |
Telobox-containing general regulatory factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PNG1 |
YPL096W |
Conserved peptide N-glycanase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SRO9 |
YCL037C |
Cytoplasmic RNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SNF2 |
YOR290C |
Catalytic subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MLH1 |
YMR167W |
Protein required for mismatch repair in mitosis and meiosis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RTN1 |
YDR233C |
Reticulon protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YJU3 |
YKL094W |
Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MRP10 |
YDL045W-A |
Mitochondrial ribosomal protein of the small subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VPS13 |
YLL040C |
Lipid transport protein involved in prospore membrane morphogenesis |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RGC1 |
YPR115W |
Putative regulator of the Fps1p glycerol channel |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MDS3 |
YGL197W |
Putative component of the TOR regulatory pathway |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NRP1 |
YDL167C |
Putative RNA binding protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PGI1 |
YBR196C |
Glycolytic enzyme phosphoglucose isomerase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MDY2 |
YOL111C |
Protein involved in inserting tail-anchored proteins into ER membranes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IRA1 |
YBR140C |
GTPase-activating protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PMA2 |
YPL036W |
Plasma membrane H+-ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBP13 |
YBL067C |
Ubiquitin-specific protease that cleaves Ub-protein fusions |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRB1 |
YEL060C |
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRB1 |
YEL060C |
Vacuolar proteinase B (yscB) with H3 N-terminal endopeptidase activity |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
NUP100 |
YKL068W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MDH1 |
YKL085W |
Mitochondrial malate dehydrogenase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTB1 |
YDR224C |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PEP1 |
YBL017C |
Type I transmembrane sorting receptor for multiple vacuolar hydrolases |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RBH2 |
YJR030C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SET3 |
YKR029C |
Defining member of the SET3 histone deacetylase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOM70 |
YNL121C |
Component of the TOM (translocase of outer membrane) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VIP1 |
YLR410W |
Bifunctional inositol pyrophosphate kinase and phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAS2 |
YNL098C |
GTP-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SND1 |
YDR186C |
Protein involved in SRP-independent targeting of substrates to the ER |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HOF1 |
YMR032W |
F-BAR protein that regulates actin cytoskeleton organization |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBX4 |
YMR067C |
UBX domain-containing protein that interacts with Cdc48p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YLR225C |
YLR225C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PYP1 |
YNL010W |
Sugar alcohol phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SPR28 |
YDR218C |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IRA2 |
YOL081W |
GTPase-activating protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YHR214C-C |
YHR214C-C |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
XRS2 |
YDR369C |
FHA domain-containing component of the Mre11 complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PCA1 |
YBR295W |
Cadmium transporting P-type ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PIP2 |
YOR363C |
Autoregulatory, oleate-activated transcription factor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SIP1 |
YDR422C |
One of three alternate beta-subunits of the Snf1p kinase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PRP2 |
YNR011C |
RNA-dependent DExD/H-box ATPase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
LAP2 |
YNL045W |
Leucyl aminopeptidase yscIV with epoxide hydrolase activity |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SEC7 |
YDR170C |
Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
IQG1 |
YPL242C |
Actin filament binding protein that enhances actin ring formation |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RTG1 |
YOL067C |
Transcription factor (bHLH) involved in interorganelle communication |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPO21 |
YDL140C |
RNA polymerase II largest subunit B220 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TIF4632 |
YGL049C |
Translation initiation factor eIF4G and scaffold protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RAD52 |
YML032C |
Protein involved in homologous recombination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SWI6 |
YLR182W |
Transcription cofactor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MSH4 |
YFL003C |
Protein involved in meiotic recombination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YHR131C |
YHR131C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
RPC82 |
YPR190C |
RNA polymerase III subunit C82 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MVP1 |
YMR004W |
Protein required for sorting proteins to the vacuole |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PPA2 |
YMR267W |
Mitochondrial inorganic pyrophosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
VPS74 |
YDR372C |
Golgi PI4K effector, PtdIns4P sensor, and retention receptor |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HTB2 |
YBL002W |
Histone H2B |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
NVJ2 |
YPR091C |
Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HXT7 |
YDR342C |
High-affinity glucose transporter |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ISN1 |
YOR155C |
Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
PSD2 |
YGR170W |
Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
TOF1 |
YNL273W |
Subunit of a replication-pausing checkpoint complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
UTP14 |
YML093W |
Subunit of U3-containing Small Subunit (SSU) processome complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
YML020W |
YML020W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SNG1 |
YGR197C |
Protein involved in resistance to nitrosoguanidine and 6-azauracil |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SNG1 |
YGR197C |
Protein involved in resistance to nitrosoguanidine and 6-azauracil |
genetic |
1 |
1 |
1 |
Negative Genetic |
RTT102 |
YGR275W |
Component of both the SWI/SNF and RSC chromatin remodeling complexes |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
MCO10 |
YOR020W-A |
Mitochondrial protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
SSB2 |
YNL209W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
1 |
1 |
1 |
Co-purification |
RPS2 |
YGL123W |
Protein component of the small (40S) subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
RNH70 |
YGR276C |
3'-5' exoribonuclease |
physical |
1 |
1 |
1 |
PCA |
RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
physical |
1 |
1 |
1 |
PCA |
RPL14B |
YHL001W |
Ribosomal 60S subunit protein L14B |
physical |
1 |
1 |
1 |
PCA |
LEU1 |
YGL009C |
Isopropylmalate isomerase |
physical |
1 |
1 |
1 |
PCA |
RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
physical |
1 |
1 |
1 |
PCA |
RNA14 |
YMR061W |
Component of the cleavage and polyadenylation factor I (CF I) |
genetic |
1 |
1 |
1 |
Positive Genetic |
NEM1 |
YHR004C |
Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme |
physical |
1 |
1 |
1 |
PCA |
PKH3 |
YDR466W |
Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p |
physical |
1 |
1 |
1 |
PCA |
PKH2 |
YOL100W |
Serine/threonine protein kinase |
physical |
1 |
1 |
1 |
PCA |
TRA1 |
YHR099W |
Subunit of SAGA and NuA4 histone acetyltransferase complexes |
physical |
1 |
1 |
1 |
PCA |
TRA1 |
YHR099W |
Subunit of SAGA and NuA4 histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UBA2 |
YDR390C |
Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p |
physical |
1 |
1 |
1 |
PCA |
PIB2 |
YGL023C |
Phosphatidylinositol 3-phosphate binding protein |
physical |
1 |
1 |
1 |
PCA |
LAM1 |
YHR155W |
Putative sterol transfer protein |
physical |
1 |
1 |
1 |
PCA |
RRP45 |
YDR280W |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
PCA |
RPA12 |
YJR063W |
RNA polymerase I subunit A12.2 |
physical |
1 |
1 |
1 |
PCA |
RAD5 |
YLR032W |
DNA helicase/Ubiquitin ligase |
physical |
1 |
1 |
1 |
PCA |
TRP3 |
YKL211C |
Indole-3-glycerol-phosphate synthase |
physical |
1 |
1 |
1 |
PCA |
YFL040W |
YFL040W |
Putative transporter |
physical |
1 |
1 |
1 |
PCA |
STB2 |
YMR053C |
Protein that interacts with Sin3p in a two-hybrid assay |
physical |
1 |
1 |
1 |
PCA |
VTS1 |
YOR359W |
Flap-structured DNA-binding and RNA-binding protein |
physical |
1 |
1 |
1 |
PCA |
SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
physical |
1 |
1 |
1 |
PCA |
SCD6 |
YPR129W |
Repressor of translation initiation |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
PUF2 |
YPR042C |
PUF family mRNA-binding protein |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
HTS1 |
YPR033C |
Cytoplasmic and mitochondrial histidine tRNA synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
MPP10 |
YJR002W |
Component of the SSU processome and 90S preribosome |
physical |
1 |
1 |
1 |
Biochemical Activity |
MRD1 |
YPR112C |
Essential conserved small ribosomal subunit (40s) synthesis factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
NUG1 |
YER006W |
GTPase that associates with nuclear 60S pre-ribosomes |
physical |
1 |
1 |
1 |
Biochemical Activity |
PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
physical |
1 |
1 |
1 |
Biochemical Activity |
RPA43 |
YOR340C |
RNA polymerase I subunit A43 |
physical |
1 |
1 |
1 |
Biochemical Activity |
RRP43 |
YCR035C |
Exosome non-catalytic core component |
physical |
1 |
1 |
1 |
Biochemical Activity |
SPP381 |
YBR152W |
mRNA splicing factor, component of U4/U6.U5 tri-snRNP |
physical |
1 |
1 |
1 |
Biochemical Activity |
UTP4 |
YDR324C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
physical |
1 |
1 |
1 |
Biochemical Activity |
PUF4 |
YGL014W |
Member of the PUF protein family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
PHO4 |
YFR034C |
Basic helix-loop-helix (bHLH) transcription factor of the myc-family |
physical |
1 |
1 |
1 |
Biochemical Activity |
SNU56 |
YDR240C |
Component of U1 snRNP required for mRNA splicing via spliceosome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
UBI4 |
YLL039C |
Ubiquitin |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRM7 |
YBR061C |
2'-O-ribose methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRM1 |
YOR201C |
Ribose methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSK1 |
YNL073W |
Mitochondrial lysine-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRM3 |
YDL112W |
2'-O-ribose methyltransferase |
genetic |
1 |
1 |
1 |
Positive Genetic |
LOT5 |
YKL183W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
RNH201 |
YNL072W |
Ribonuclease H2 catalytic subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
TEF2 |
YBR118W |
Translational elongation factor EF-1 alpha |
genetic |
1 |
1 |
1 |
Positive Genetic |
SUI2 |
YJR007W |
Alpha subunit of the translation initiation factor eIF2 |
genetic |
1 |
1 |
1 |
Positive Genetic |
THP3 |
YPR045C |
Protein that may have a role in transcription elongation |
genetic |
1 |
1 |
1 |
Positive Genetic |
SRP101 |
YDR292C |
Signal recognition particle (SRP) receptor alpha subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
VOA1 |
YGR106C |
ER protein that functions in assembly of the V0 sector of V-ATPase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HST3 |
YOR025W |
Sirtuin, histone H3 deacetylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ICP55 |
YER078C |
Mitochondrial aminopeptidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
JEM1 |
YJL073W |
DnaJ-like chaperone required for nuclear membrane fusion during mating |
genetic |
1 |
1 |
1 |
Positive Genetic |
KRE28 |
YDR532C |
Subunit of a kinetochore-microtubule binding complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
LDB16 |
YCL005W |
Protein involved in lipid droplet (LD) assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
LDB7 |
YBL006C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
LYS1 |
YIR034C |
Saccharopine dehydrogenase (NAD+, L-lysine-forming) |
genetic |
1 |
1 |
1 |
Negative Genetic |
MAL12 |
YGR292W |
Maltase (alpha-D-glucosidase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
MEF2 |
YJL102W |
Mitochondrial elongation factor involved in translational elongation |
genetic |
1 |
1 |
1 |
Positive Genetic |
MGM1 |
YOR211C |
Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
MIP6 |
YHR015W |
Putative RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL10 |
YNL284C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL13 |
YKR006C |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL35 |
YDR322W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MRPL51 |
YPR100W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSN1 |
YOL116W |
Transcriptional activator |
genetic |
1 |
1 |
1 |
Positive Genetic |
MSN5 |
YDR335W |
Karyopherin |
genetic |
1 |
1 |
1 |
Negative Genetic |
NGG1 |
YDR176W |
Subunit of chromatin modifying histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
NGL3 |
YML118W |
3'-5' exonuclease specific for poly-A RNAs |
genetic |
1 |
1 |
1 |
Positive Genetic |
NOT5 |
YPR072W |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
genetic |
1 |
1 |
1 |
Positive Genetic |
NUT1 |
YGL151W |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
OCH1 |
YGL038C |
Mannosyltransferase of the cis-Golgi apparatus |
genetic |
1 |
1 |
1 |
Negative Genetic |
PEP12 |
YOR036W |
Target membrane receptor (t-SNARE) |
genetic |
1 |
1 |
1 |
Negative Genetic |
PEX14 |
YGL153W |
Central component of the peroxisomal importomer complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
1 |
1 |
1 |
Negative Genetic |
PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Negative Genetic |
PML39 |
YML107C |
Protein required for nuclear retention of unspliced pre-mRNAs |
genetic |
1 |
1 |
1 |
Positive Genetic |
POC4 |
YPL144W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
POS5 |
YPL188W |
Mitochondrial NADH kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE9 |
YGR135W |
Alpha 3 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAD51 |
YER095W |
Strand exchange protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
RAD6 |
YGL058W |
Ubiquitin-conjugating enzyme (E2) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIB1 |
YBL033C |
GTP cyclohydrolase II |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM101 |
YHL027W |
Cys2His2 zinc-finger transcriptional repressor |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM20 |
YOR275C |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RIM8 |
YGL045W |
Protein involved in proteolytic activation of Rim101p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RMD6 |
YEL072W |
Protein required for sporulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL19A |
YBR084C-A |
Ribosomal 60S subunit protein L19A |
genetic |
1 |
1 |
1 |
Positive Genetic |
RPL31A |
YDL075W |
Ribosomal 60S subunit protein L31A |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPL9A |
YGL147C |
Ribosomal 60S subunit protein L9A |
genetic |
1 |
1 |
1 |
Negative Genetic |
RXT3 |
YDL076C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SEC28 |
YIL076W |
Epsilon-COP subunit of the coatomer |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGF73 |
YGL066W |
Subunit of DUBm module of SAGA and SLIK |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SLM5 |
YCR024C |
Mitochondrial asparaginyl-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNF6 |
YHL025W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNF7 |
YLR025W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNZ1 |
YMR096W |
Subunit of a two-component pyridoxal-5'-phosphate synthase |
genetic |
1 |
1 |
1 |
Positive Genetic |
SOH1 |
YGL127C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SPO13 |
YHR014W |
Meiotic regulator |
genetic |
1 |
1 |
1 |
Negative Genetic |
SPT2 |
YER161C |
Protein involved in negative regulation of transcription |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSN8 |
YNL025C |
Cyclin-like component of RNA polymerase II holoenzyme |
genetic |
1 |
1 |
1 |
Positive Genetic |
STE50 |
YCL032W |
Adaptor protein for various signaling pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI3 |
YJL176C |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TFB5 |
YDR079C-A |
Component of RNA polymerase II general transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA1 |
YDL185W |
Subunit A of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
THR1 |
YHR025W |
Homoserine kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
TPD3 |
YAL016W |
Regulatory subunit A of the heterotrimeric PP2A complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TRP1 |
YDR007W |
Phosphoribosylanthranilate isomerase |
genetic |
1 |
1 |
1 |
Positive Genetic |
TVP18 |
YMR071C |
Integral membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBP14 |
YBR058C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Positive Genetic |
UMP1 |
YBR173C |
Chaperone required for correct maturation of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA5 |
YKL080W |
Subunit C of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA7 |
YGR020C |
Subunit F of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VMA8 |
YEL051W |
Subunit D of the V1 peripheral membrane domain of V-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS16 |
YPL045W |
Subunit of the HOPS and the CORVET complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
VPS20 |
YMR077C |
Myristoylated subunit of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
WHI5 |
YOR083W |
Repressor of G1 transcription |
genetic |
1 |
1 |
1 |
Positive Genetic |
YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Positive Genetic |
YGK3 |
YOL128C |
Protein kinase related to mammalian GSK-3 glycogen synthase kinases |
genetic |
1 |
1 |
1 |
Positive Genetic |
YGL159W |
YGL159W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YHI9 |
YHR029C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YIP5 |
YGL161C |
Protein that interacts with Rab GTPases |
genetic |
1 |
1 |
1 |
Negative Genetic |
YJR011C |
YJR011C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
YPR063C |
YPR063C |
ER-localized protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPR071W |
YPR071W |
Putative membrane protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
YPR084W |
YPR084W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
YRB30 |
YGL164C |
RanGTP-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
SDS3 |
YIL084C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UME1 |
YPL139C |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
YKU70 |
YMR284W |
Subunit of the telomeric Ku complex (Yku70p-Yku80p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
TTI1 |
YKL033W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Positive Genetic |
POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
STP22 |
YCL008C |
Component of the ESCRT-I complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
SOM1 |
YEL059C-A |
Subunit of the mitochondrial inner membrane peptidase (IMP) |
genetic |
1 |
1 |
1 |
Positive Genetic |
UBC1 |
YDR177W |
Ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Negative Genetic |
UTP8 |
YGR128C |
Nucleolar protein required for export of tRNAs from the nucleus |
genetic |
1 |
1 |
1 |
Negative Genetic |
KOG1 |
YHR186C |
Subunit of TORC1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAO3 |
YIL129C |
Component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
SSC1 |
YJR045C |
Hsp70 family ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
MSL5 |
YLR116W |
Component of commitment complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRP39 |
YML046W |
U1 snRNP protein involved in splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RRP5 |
YMR229C |
RNA binding protein involved in synthesis of 18S and 5.8S rRNAs |
genetic |
1 |
1 |
1 |
Negative Genetic |
RNA1 |
YMR235C |
GTPase activating protein (GAP) for Gsp1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAP1 |
YNL216W |
Essential DNA-binding transcription regulator that binds many loci |
genetic |
1 |
1 |
1 |
Negative Genetic |
KRI1 |
YNL308C |
Essential nucleolar protein required for 40S ribosome biogenesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
SEC12 |
YNR026C |
Guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPB11 |
YOL005C |
RNA polymerase II subunit B12.5 |
genetic |
1 |
1 |
1 |
Negative Genetic |
RAT1 |
YOR048C |
Nuclear 5' to 3' single-stranded RNA exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
SWI1 |
YPL016W |
Subunit of the SWI/SNF chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPN7 |
YPR108W |
Essential non-ATPase regulatory subunit of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
SNU23 |
YDL098C |
Component of the U4/U6.U5 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
TAF6 |
YGL112C |
Subunit (60 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
genetic |
1 |
1 |
1 |
Negative Genetic |
KRE9 |
YJL174W |
Glycoprotein involved in cell wall beta-glucan assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
PRE2 |
YPR103W |
Beta 5 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
LEA1 |
YPL213W |
Component of U2 snRNP complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
RSM26 |
YJR101W |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
RPS6B |
YBR181C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
STE7 |
YDL159W |
Signal transducing MAP kinase kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
LYS4 |
YDR234W |
Homoaconitase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
IES1 |
YFL013C |
Subunit of the INO80 chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ZRT1 |
YGL255W |
High-affinity zinc transporter of the plasma membrane |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
YGR122W |
YGR122W |
Protein that may be involved in pH regulation |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
JJJ1 |
YNL227C |
Co-chaperone that stimulates the ATPase activity of Ssa1p |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
VPS5 |
YOR069W |
Nexin-1 homolog |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
VAM6 |
YDL077C |
Guanine nucleotide exchange factor for the GTPase Gtr1p |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
VPS53 |
YJL029C |
Component of the GARP (Golgi-associated retrograde protein) complex |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
YPT7 |
YML001W |
Rab family GTPase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
URA5 |
YML106W |
Major orotate phosphoribosyltransferase (OPRTase) isozyme |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
MAC1 |
YMR021C |
Copper-sensing transcription factor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
VAM10 |
YOR068C |
Protein involved in vacuole morphogenesis |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
RAM1 |
YDL090C |
Beta subunit of the CAAX farnesyltransferase (FTase) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
TMA7 |
YLR262C-A |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
MIR1 |
YJR077C |
Mitochondrial phosphate carrier |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
SIR3 |
YLR442C |
Silencing protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
VPS9 |
YML097C |
Guanine nucleotide exchange factor (GEF) and ubiquitin receptor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Positive Genetic |
SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
1 |
1 |
1 |
Positive Genetic |
CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HHT2 |
YNL031C |
Histone H3 |
physical |
1 |
1 |
1 |
Biochemical Activity |
BCS1 |
YDR375C |
Protein translocase and chaperone required for Complex III assembly |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
HBT1 |
YDL223C |
Shmoo tip protein, substrate of Hub1p ubiquitin-like protein |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERG28 |
YER044C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
FMP27 |
YLR454W |
Protein with structural similarity to lipid transport protein Vps13p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HMG1 |
YML075C |
HMG-CoA reductase |
genetic |
1 |
1 |
1 |
Positive Genetic |
ADE1 |
YAR015W |
N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
CSF1 |
YLR087C |
Protein with structural similarity to lipid transport protein Vps13p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
HEM14 |
YER014W |
Protoporphyrinogen oxidase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARI1 |
YGL157W |
NADPH-dependent aldehyde reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BUL2 |
YML111W |
Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARG56 |
YER069W |
Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
HIS6 |
YIL020C |
Enzyme that catalyzes the fourth step in the histidine pathway |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
CAJ1 |
YER048C |
Nuclear type II J heat shock protein of the E. coli dnaJ family |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GSH1 |
YJL101C |
Gamma glutamylcysteine synthetase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
DOS2 |
YDR068W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ARO2 |
YGL148W |
Bifunctional chorismate synthase and flavin reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EST2 |
YLR318W |
Reverse transcriptase subunit of the telomerase holoenzyme |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
COX11 |
YPL132W |
Protein required for delivery of copper to Cox1p |
genetic |
1 |
1 |
1 |
Positive Genetic |
CHS2 |
YBR038W |
Chitin synthase II |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
ERP4 |
YOR016C |
Member of the p24 family involved in ER to Golgi transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
COS7 |
YDL248W |
Endosomal protein involved in turnover of plasma membrane proteins |
genetic |
1 |
1 |
1 |
Negative Genetic |
ADK2 |
YER170W |
Mitochondrial adenylate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
BRR6 |
YGL247W |
Essential nuclear envelope integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
EDS1 |
YBR033W |
Putative zinc cluster protein, predicted to be a transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
EFM5 |
YGR001C |
S-adenosylmethionine-dependent lysine methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
EMC10 |
YDR056C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
BIO4 |
YNR057C |
Dethiobiotin synthetase |
physical |
1 |
1 |
1 |
PCA |
HMI1 |
YOL095C |
Mitochondrial inner membrane localized ATP-dependent DNA helicase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
GPI11 |
YDR302W |
ER membrane protein involved in a late step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
ALP1 |
YNL270C |
Arginine transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
GRX8 |
YLR364W |
Glutaredoxin that employs a dithiol mechanism of catalysis |
genetic |
1 |
1 |
1 |
Negative Genetic |
ECM12 |
YHR021W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |