Standard name Systematic name Name description Description
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes Subunit (17 kDa) of TFIID and SAGA complexes; involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3
Visualize the interactome of TAF9
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.362 0.46 0.368
Nucleus 0.930 0.90 0.902
Mito NaN NaN 0.068

GFP localization & abundance

GFP localization GFP abundance
nucleus 6580

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
TAF9 5 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 21 6 15 Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Co-purification, Co-purification
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes physical 19 5 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Co-purification
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex physical 18 3 16 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Co-purification
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 18 4 15 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Co-localization, Affinity Capture-MS, Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes physical 16 5 12 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-localization, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Co-purification
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 15 4 9 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Co-purification, Co-purification
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes physical 12 4 12 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Co-purification, Affinity Capture-MS, Co-localization, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 11 4 8 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 10 4 8 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-purification
ADA2 YDR448W Transcription coactivator physical 10 3 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes physical 9 4 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Co-purification
TAF4 YMR005W TFIID subunit (48 kDa) physical 9 3 7 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
TAF13 YML098W TFIID subunit (19 kDa) physical 8 1 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
TAF11 YML015C TFIID subunit (40 kDa) physical 8 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SPT15 YER148W TATA-binding protein (TBP) physical 8 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-localization, Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 7 3 7 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 7 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex physical 6 2 5 Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 6 2 5 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SWC5 YBR231C Component of the SWR1 complex genetic 6 4 4 Negative Genetic, Phenotypic Enhancement, Positive Genetic, Synthetic Lethality, Synthetic Lethality, Positive Genetic
TAF3 YPL011C TFIID subunit (47 kDa) physical 6 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes physical 5 2 5 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Co-purification
TAF2 YCR042C TFIID subunit (150 kDa) physical 5 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 5 2 4 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 5 2 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes physical 5 3 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 5 3 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 5 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 5 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 4 2 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex
TAF8 YML114C TFIID subunit (65 kDa) physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 4 3 2 Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 3 3 2 Negative Genetic, Phenotypic Enhancement, Synthetic Lethality
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 2 2 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 3 2 2 Positive Genetic, Synthetic Lethality, Synthetic Lethality
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
FYV4 YHR059W Protein of unknown function genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
HTZ1 YOL012C Histone variant H2AZ genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SWI6 YLR182W Transcription cofactor genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 2 2 2 Dosage Rescue, Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 2 1 2 Positive Genetic, Positive Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
BLM10 YFL007W Proteasome activator genetic 2 1 2 Positive Genetic, Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 2 1 2 Positive Genetic, Positive Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 2 1 2 Positive Genetic, Positive Genetic
OM45 YIL136W Mitochondrial outer membrane protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 2 1 2 Negative Genetic, Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 2 1 2 Positive Genetic, Positive Genetic
YCR090C YCR090C Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
YLR287C YLR287C Putative protein of unknown function genetic 2 1 2 Positive Genetic, Positive Genetic
YOL162W YOL162W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Positive Genetic, Positive Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 2 1 2 Positive Genetic, Positive Genetic
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
EHT1 YBR177C Octanoyl-CoA:ethanol acyltransferase genetic 2 1 2 Positive Genetic, Positive Genetic
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 2 1 2 Negative Genetic, Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 2 1 2 Positive Genetic, Positive Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 2 1 2 Negative Genetic, Negative Genetic
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 2 1 2 Positive Genetic, Positive Genetic
SHE1 YBL031W Mitotic spindle protein genetic 2 1 2 Positive Genetic, Positive Genetic
PRY1 YJL079C Lipid binding protein genetic 2 1 2 Positive Genetic, Positive Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 2 1 2 Positive Genetic, Positive Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 2 1 2 Positive Genetic, Positive Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
IKI3 YLR384C Subunit of Elongator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPL27A YHR010W Ribosomal 60S subunit protein L27A genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NPL3 YDR432W RNA-binding protein genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPB4 YJL140W RNA polymerase II subunit B32 genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
BDF1 YLR399C BET family transcriptional regulator genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DOA4 YDR069C Ubiquitin hydrolase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
REF2 YDR195W RNA-binding protein genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MRPL6 YHR147C Mitochondrial ribosomal protein of the large subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPB9 YGL070C RNA polymerase II subunit B12.6 genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 1 1 Negative Genetic, Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 2 1 1 Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DSS1 YMR287C 3'-5' exoribonuclease genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
IBA57 YJR122W Protein involved in incorporating iron-sulfur clusters into proteins genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MSN5 YDR335W Karyopherin genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
TAF8 YML114C TFIID subunit (65 kDa) genetic 2 1 1 Negative Genetic, Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VAN1 YML115C Component of the mannan polymerase I genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VAC14 YLR386W Enzyme regulator genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
YNG1 YOR064C Subunit of the NuA3 histone acetyltransferase complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ZAP1 YJL056C Zinc-regulated transcription factor genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 2 1 1 Negative Genetic, Negative Genetic
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MET1 YKR069W S-adenosyl-L-methionine uroporphyrinogen III transmethylase genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
KRE28 YDR532C Subunit of a kinetochore-microtubule binding complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FYV6 YNL133C Protein of unknown function genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RIM13 YMR154C Calpain-like cysteine protease genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ILM1 YJR118C Protein of unknown function genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 2 1 1 Negative Genetic, Negative Genetic
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes regulation 1 1 1 DNA to cDNA expression microarray evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Affinity Capture-MS
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 physical 1 1 1 Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Positive Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 1 1 1 Affinity Capture-MS
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes physical 1 1 1 Affinity Capture-MS
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog physical 1 1 1 Affinity Capture-MS
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme physical 1 1 1 Affinity Capture-MS
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Two-hybrid
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Positive Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking physical 1 1 1 Affinity Capture-MS
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Negative Genetic
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Positive Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex physical 1 1 1 PCA
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase physical 1 1 1 Affinity Capture-MS
MOT1 YPL082C Essential protein involved in regulation of transcription physical 1 1 1 Affinity Capture-Western
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 Affinity Capture-MS
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Positive Genetic
NPL4 YBR170C Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Positive Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Positive Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A physical 1 1 1 Affinity Capture-MS
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
PCI8 YIL071C Possible shared subunit of Cop9 signalosome (CSN) and eIF3 genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 Affinity Capture-MS
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
RPP2B YDR382W Ribosomal protein P2 beta physical 1 1 1 Affinity Capture-MS
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Positive Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Positive Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Synthetic Lethality
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Affinity Capture-MS
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Positive Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Positive Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
GYP6 YJL044C GTPase-activating protein (GAP) for yeast Rab family member Ypt6p genetic 1 1 1 Negative Genetic
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
MLH3 YPL164C Protein involved in DNA mismatch repair and meiotic recombination physical 1 1 1 Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Affinity Capture-MS
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Positive Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Dosage Rescue
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Positive Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Negative Genetic
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
BOP2 YLR267W Protein of unknown function genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Positive Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
NOP53 YPL146C Nucleolar protein genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Positive Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Negative Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Positive Genetic
BIT2 YBR270C Subunit of TORC2 membrane-associated complex physical 1 1 1 Two-hybrid
ADE2 YOR128C Phosphoribosylaminoimidazole carboxylase physical 1 1 1 Two-hybrid
CIT2 YCR005C Citrate synthase, peroxisomal isozyme involved in glyoxylate cycle genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Positive Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Two-hybrid
RRN6 YBL014C Component of the core factor (CF) rDNA transcription factor complex physical 1 1 1 Affinity Capture-MS
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex physical 1 1 1 Affinity Capture-MS
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Positive Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex physical 1 1 1 Affinity Capture-MS
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex physical 1 1 1 Affinity Capture-MS
IKI1 YHR187W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex physical 1 1 1 Affinity Capture-MS
HTL1 YCR020W-B Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Positive Genetic
SAC3 YDR159W mRNA export factor physical 1 1 1 Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 1 1 1 Synthetic Lethality
RPP1 YHR062C Subunit of both RNase MRP and nuclear RNase P physical 1 1 1 Affinity Capture-MS
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family physical 1 1 1 Affinity Capture-MS
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
YLR157C-B YLR157C-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p physical 1 1 1 Affinity Capture-MS
TUB2 YFL037W Beta-tubulin physical 1 1 1 Affinity Capture-MS
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
TIF6 YPR016C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 physical 1 1 1 Affinity Capture-MS
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Affinity Capture-MS
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Negative Genetic
TGL2 YDR058C Triacylglycerol lipase that is localized to the mitochondria genetic 1 1 1 Negative Genetic
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Positive Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Positive Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Positive Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 1 1 1 Positive Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Positive Genetic
VHT1 YGR065C High-affinity plasma membrane H+-biotin (vitamin H) symporter genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
YOS9 YDR057W ER quality-control lectin genetic 1 1 1 Negative Genetic
YGL176C YGL176C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YIL161W YIL161W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
YOR105W YOR105W Protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
NRG2 YBR066C Transcriptional repressor genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Positive Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Positive Genetic
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Affinity Capture-MS
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Dosage Rescue
RPL1A YPL220W Ribosomal 60S subunit protein L1A physical 1 1 1 Affinity Capture-MS
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Positive Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 1 1 1 Affinity Capture-MS
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
AUA1 YFL010W-A Protein required for the negative regulation by ammonia of Gap1p genetic 1 1 1 Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
ATP14 YLR295C Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
HRD3 YLR207W ER membrane protein that plays a central role in ERAD genetic 1 1 1 Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Positive Genetic
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
ECM3 YOR092W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
SFB2 YNL049C Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 1 1 1 Positive Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 1 1 1 Positive Genetic
RPP2A YOL039W Ribosomal protein P2 alpha physical 1 1 1 Affinity Capture-MS
IPT1 YDR072C Inositolphosphotransferase genetic 1 1 1 Positive Genetic
RPL34A YER056C-A Ribosomal 60S subunit protein L34A physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
AIM11 YER093C-A Protein of unknown function genetic 1 1 1 Positive Genetic
PYP1 YNL010W Sugar alcohol phosphatase genetic 1 1 1 Positive Genetic
MDM38 YOL027C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A physical 1 1 1 Affinity Capture-MS
RDL1 YOR285W Thiosulfate sulfurtransferase genetic 1 1 1 Positive Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
PTR2 YKR093W Integral membrane peptide transporter genetic 1 1 1 Positive Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
MRL1 YPR079W Membrane protein physical 1 1 1 Affinity Capture-MS
NNR2 YKL151C Widely-conserved NADHX dehydratase genetic 1 1 1 Negative Genetic
MSN1 YOL116W Transcriptional activator genetic 1 1 1 Positive Genetic
HAL9 YOL089C Putative transcription factor containing a zinc finger genetic 1 1 1 Negative Genetic
DIT1 YDR403W Sporulation-specific enzyme required for spore wall maturation physical 1 1 1 Affinity Capture-MS
NCW1 YMR122W-A Protein of unknown function genetic 1 1 1 Negative Genetic
QCR9 YGR183C Subunit 9 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
MTC3 YGL226W Protein of unknown function genetic 1 1 1 Positive Genetic
LDS2 YOL047C Protein Involved in spore wall assembly genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
GAS4 YOL132W 1,3-beta-glucanosyltransferase genetic 1 1 1 Negative Genetic
SVL3 YPL032C Protein of unknown function genetic 1 1 1 Negative Genetic
MRX19 YDL183C Protein that may form an active mitochondrial KHE system genetic 1 1 1 Negative Genetic
RIB2 YOL066C Bifunctional DRAP deaminase tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
RPS30B YOR182C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
OPI10 YOL032W Protein with a possible role in phospholipid biosynthesis genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Positive Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 1 1 1 Negative Genetic
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Negative Genetic
FRE7 YOL152W Putative ferric reductase with similarity to Fre2p genetic 1 1 1 Positive Genetic
MMO1 YKL044W Protein of unknown function genetic 1 1 1 Negative Genetic