Standard name Systematic name Name description Description
ERG11 YHR007C Lanosterol 14-alpha-demethylase Lanosterol 14-alpha-demethylase; catalyzes C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in ergosterol biosynthesis pathway; transcriptionally down-regulated when ergosterol is in excess; member of cytochrome P450 family; associated and coordinately regulated with the P450 reductase Ncp1p; human CYP51A1 functionally complements the lethality of the erg11 null mutation
Visualize the interactome of ERG11
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.084 0.123 0.050
ER 0.853 0.869 0.883
Cell Periphery NaN 0.070 0.119
Golgi NaN NaN 0.138

GFP localization & abundance

GFP localization GFP abundance
ER 73200

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
ERG11 2 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_0317 (cytochrome P450 lanosterol 14-alpha-demethylase (NADP))

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
DAP1 YPL170W Heme-binding protein genetic 5 3 5 Synthetic Lethality, Dosage Rescue, Negative Genetic, Dosage Rescue, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 4 3 4 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
ERG3 YLR056W C-5 sterol desaturase genetic 4 3 4 Synthetic Rescue, Synthetic Growth Defect, Positive Genetic, Positive Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
ERG28 YER044C Endoplasmic reticulum membrane protein physical 4 3 2 Two-hybrid, Affinity Capture-Western, PCA, PCA
CUE1 YMR264W Ubiquitin-binding protein genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 3 2 2 Positive Genetic, Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
ERG25 YGR060W C-4 methyl sterol oxidase physical 3 1 2 PCA, PCA, PCA
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
INO2 YDR123C Transcription factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
URA2 YJL130C Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 3 2 1 Positive Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 2 2 2 PCA, Affinity Capture-MS
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 2 2 Synthetic Lethality, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 2 2 2 Synthetic Lethality, Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 2 2 2 Synthetic Lethality, Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 2 2 2 Synthetic Lethality, Positive Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 2 2 2 Synthetic Lethality, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPC17 YJL011C RNA polymerase III subunit C17 genetic 2 2 2 Synthetic Lethality, Negative Genetic
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 2 2 2 Synthetic Lethality, Negative Genetic
CRS1 YNL247W Cysteinyl-tRNA synthetase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ARV1 YLR242C Cortical ER protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
ASI1 YMR119W Subunit of the inner nuclear membrane Asi ubiquitin ligase complex physical 2 2 2 Affinity Capture-Western, Biochemical Activity
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 2 1 2 Negative Genetic, Negative Genetic
ERG11 YHR007C Lanosterol 14-alpha-demethylase physical 2 1 2 PCA, PCA
PKR1 YMR123W V-ATPase assembly factor genetic 2 1 2 Negative Genetic, Negative Genetic
LAC1 YKL008C Ceramide synthase component physical 2 1 2 PCA, PCA
STE24 YJR117W Highly conserved zinc metalloprotease physical 2 1 2 PCA, PCA
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 2 1 2 Negative Genetic, Negative Genetic
PPR1 YLR014C Zinc finger transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
URA4 YLR420W Dihydroorotase genetic 2 1 2 Negative Genetic, Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
PHO80 YOL001W Cyclin genetic 2 1 2 Negative Genetic, Negative Genetic
ATG1 YGL180W Protein serine/threonine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
ARO7 YPR060C Chorismate mutase genetic 2 1 2 Negative Genetic, Negative Genetic
EMC3 YKL207W Member of conserved ER transmembrane complex genetic 2 1 2 Negative Genetic, Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 2 2 1 Positive Genetic, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 1 Positive Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 1 Positive Genetic, Negative Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 2 1 1 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 1 1 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Negative Genetic, Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 1 Positive Genetic, Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Positive Genetic, Positive Genetic
GPI17 YDR434W Transmembrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 2 1 1 PCA, PCA
ERG27 YLR100W 3-keto sterol reductase physical 2 1 1 PCA, PCA
ERG7 YHR072W Lanosterol synthase physical 2 1 1 PCA, PCA
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MAK5 YBR142W Essential nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 2 1 1 Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 2 1 1 Negative Genetic, Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 2 1 1 Negative Genetic, Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 2 1 1 Negative Genetic, Negative Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 2 1 1 Negative Genetic, Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 2 1 1 Negative Genetic, Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 2 1 1 Negative Genetic, Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 2 1 1 Negative Genetic, Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 2 1 1 Negative Genetic, Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 2 1 1 Negative Genetic, Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 2 1 1 Negative Genetic, Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 2 1 1 Negative Genetic, Negative Genetic
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 2 1 1 Negative Genetic, Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia regulation 1 1 1 DNA to cDNA expression microarray evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP1 YLR256W Zinc finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SET4 YJL105W Chromatin-associated protein involved in control of stress response regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
DRS1 YLL008W Nucleolar DEAD-box protein required for ribosome assembly and function genetic 1 1 1 Synthetic Growth Defect
CAB3 YKL088W Subunit of PPCDC and CoA-SPC complexes involved in CoA biosynthesis physical 1 1 1 PCA
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Lethality
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Negative Genetic
ARP7 YPR034W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
ARP9 YMR033W Component of both the SWI/SNF and RSC chromatin remodeling complexes genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP genetic 1 1 1 Synthetic Lethality
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Synthetic Lethality
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly genetic 1 1 1 Negative Genetic
AIM21 YIR003W Subunit of a complex that associates with actin filaments genetic 1 1 1 Positive Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Positive Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Negative Genetic
CYS4 YGR155W Cystathionine beta-synthase physical 1 1 1 Affinity Capture-MS
CYS4 YGR155W Cystathionine beta-synthase genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
DIB1 YPR082C 17-kDa component of the U4/U6aU5 tri-snRNP genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
AVT4 YNL101W Vacuolar transporter physical 1 1 1 PCA
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
APP1 YNL094W Phosphatidate phosphatase, converts phosphatidate to diacylglycerol genetic 1 1 1 Negative Genetic
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic genetic 1 1 1 Synthetic Lethality
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Negative Genetic
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Synthetic Growth Defect
ERG1 YGR175C Squalene epoxidase genetic 1 1 1 Phenotypic Enhancement
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III genetic 1 1 1 Positive Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Synthetic Growth Defect
EPT1 YHR123W sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase physical 1 1 1 PCA
DAP1 YPL170W Heme-binding protein physical 1 1 1 Co-fractionation
CYS3 YAL012W Cystathionine gamma-lyase genetic 1 1 1 Negative Genetic
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
SSH1 YBR283C Subunit of the Ssh1 translocon complex physical 1 1 1 PCA
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase physical 1 1 1 PCA
SRP14 YDL092W Signal recognition particle (SRP) subunit physical 1 1 1 PCA
RTN2 YDL204W Reticulon protein physical 1 1 1 PCA
SHR3 YDL212W Endoplasmic reticulum packaging chaperone physical 1 1 1 PCA
SUR2 YDR297W Sphinganine C4-hydroxylase physical 1 1 1 PCA
GPI17 YDR434W Transmembrane protein physical 1 1 1 PCA
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
OLE1 YGL055W Delta(9) fatty acid desaturase physical 1 1 1 PCA
HNM1 YGL077C Plasma membrane transporter for choline, ethanolamine, and carnitine physical 1 1 1 PCA
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Synthetic Rescue
VMA21 YGR105W Integral membrane protein required for V-ATPase function physical 1 1 1 PCA
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
ERV29 YGR284C Protein localized to COPII-coated vesicles physical 1 1 1 PCA
SHU1 YHL006C Component of Shu complex (aka PCSS complex) physical 1 1 1 PCA
MID2 YLR332W O-glycosylated plasma membrane protein physical 1 1 1 PCA
SWP1 YMR149W Delta subunit of the oligosaccharyl transferase glycoprotein complex physical 1 1 1 PCA
NCP1 YHR042W NADP-cytochrome P450 reductase physical 1 1 1 PCA
NCP1 YHR042W NADP-cytochrome P450 reductase genetic 1 1 1 Synthetic Lethality
PIS1 YPR113W Phosphatidylinositol synthase physical 1 1 1 PCA
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) physical 1 1 1 PCA
ERG5 YMR015C C-22 sterol desaturase physical 1 1 1 PCA
PKR1 YMR123W V-ATPase assembly factor physical 1 1 1 PCA
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 PCA
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 1 1 1 PCA
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 PCA
NDI1 YML120C NADH:ubiquinone oxidoreductase physical 1 1 1 PCA
OSH6 YKR003W Oxysterol-binding phosphatidylserine transferase physical 1 1 1 PCA
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) physical 1 1 1 PCA
SOP4 YJL192C ER-membrane protein physical 1 1 1 PCA
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 1 1 1 PCA
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger physical 1 1 1 PCA
SCS7 YMR272C Sphingolipid alpha-hydroxylase physical 1 1 1 PCA
SPC2 YML055W Subunit of signal peptidase complex physical 1 1 1 PCA
SEC62 YPL094C Essential subunit of Sec63 complex physical 1 1 1 PCA
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion physical 1 1 1 PCA
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily physical 1 1 1 PCA
GTT1 YIR038C ER associated glutathione S-transferase physical 1 1 1 PCA
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p physical 1 1 1 PCA
HYR1 YIR037W Glutathione peroxidase physical 1 1 1 PCA
ILM1 YJR118C Protein of unknown function physical 1 1 1 PCA
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein physical 1 1 1 PCA
ERG4 YGL012W C-24(28) sterol reductase physical 1 1 1 PCA
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Synthetic Growth Defect
ERG24 YNL280C C-14 sterol reductase physical 1 1 1 PCA
ERG26 YGL001C C-3 sterol dehydrogenase physical 1 1 1 PCA
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Positive Genetic
ERG3 YLR056W C-5 sterol desaturase physical 1 1 1 PCA
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) physical 1 1 1 PCA
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex physical 1 1 1 PCA
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
MNN4 YKL201C Putative positive regulator of mannosylphosphate transferase Mnn6p physical 1 1 1 PCA
TRK2 YKR050W Component of the Trk1p-Trk2p potassium transport system physical 1 1 1 PCA
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit physical 1 1 1 PCA
YBT1 YLL048C Transporter of the ATP-binding cassette (ABC) family physical 1 1 1 PCA
TOM7 YNL070W Component of the TOM (translocase of outer membrane) complex physical 1 1 1 PCA
SAM3 YPL274W High-affinity S-adenosylmethionine permease physical 1 1 1 PCA
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI physical 1 1 1 PCA
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 1 1 1 Affinity Capture-MS
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Co-localization
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
GIS1 YDR096W Histone demethylase and transcription factor physical 1 1 1 Affinity Capture-MS
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Synthetic Lethality
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Synthetic Lethality
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Synthetic Lethality
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Synthetic Lethality
YPT31 YER031C Rab family GTPase genetic 1 1 1 Synthetic Lethality
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Synthetic Lethality
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Lethality
YHR045W YHR045W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Lethality
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Synthetic Lethality
PDR16 YNL231C Phosphatidylinositol transfer protein (PITP) genetic 1 1 1 Synthetic Lethality
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Synthetic Lethality
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Synthetic Lethality
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
VAC14 YLR386W Enzyme regulator genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Negative Genetic
FUI1 YBL042C High affinity uridine permease, localizes to the plasma membrane genetic 1 1 1 Negative Genetic
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YBR219C YBR219C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUL1 YBR294W High affinity sulfate permease of the SulP anion transporter family genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Positive Genetic
STP1 YDR463W Transcription factor genetic 1 1 1 Negative Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Positive Genetic
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Negative Genetic
GEX2 YKR106W Proton:glutathione antiporter genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Negative Genetic
POM152 YMR129W Glycoprotein subunit of transmembrane ring of nuclear pore complex genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
FAA4 YMR246W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 1 1 1 Negative Genetic
MRP35 YNL122C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
NIS1 YNL078W Protein involved in axial bud site selection genetic 1 1 1 Positive Genetic
FRE4 YNR060W Ferric reductase genetic 1 1 1 Negative Genetic
YOL024W YOL024W Putative protein of unknown function genetic 1 1 1 Negative Genetic
FYV12 YOR183W Protein of unknown function genetic 1 1 1 Negative Genetic
YPL245W YPL245W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RTT10 YPL183C WD40 domain-containing protein involved in endosomal recycling genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Positive Genetic
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
NVJ2 YPR091C Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ) genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Synthetic Growth Defect
LSM4 YER112W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Synthetic Growth Defect
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Synthetic Growth Defect
NOP8 YOL144W Nucleolar protein required for 60S ribosomal subunit biogenesis genetic 1 1 1 Synthetic Growth Defect
NUG1 YER006W GTPase that associates with nuclear 60S pre-ribosomes genetic 1 1 1 Synthetic Growth Defect
PFY1 YOR122C Profilin genetic 1 1 1 Synthetic Growth Defect
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding genetic 1 1 1 Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Synthetic Growth Defect
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Synthetic Growth Defect
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Synthetic Growth Defect
PXR1 YGR280C Essential protein involved in rRNA and snoRNA maturation genetic 1 1 1 Synthetic Growth Defect
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Synthetic Growth Defect
SMD3 YLR147C Core Sm protein Sm D3 genetic 1 1 1 Synthetic Growth Defect
SRP21 YKL122C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Synthetic Growth Defect
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Synthetic Growth Defect
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Synthetic Growth Defect
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
TOM22 YNL131W Component of the TOM (Translocase of Outer Membrane) complex genetic 1 1 1 Synthetic Growth Defect
TRM5 YHR070W tRNA(m(1)G37)methyltransferase genetic 1 1 1 Synthetic Growth Defect
PGA1 YNL158W Essential component of GPI-mannosyltransferase II genetic 1 1 1 Synthetic Growth Defect
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Synthetic Lethality
RPC11 YDR045C RNA polymerase III subunit C11 genetic 1 1 1 Synthetic Lethality
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Synthetic Lethality
RPC53 YDL150W RNA polymerase III subunit C53 genetic 1 1 1 Synthetic Lethality
RRP14 YKL082C Essential protein, constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Lethality
UTP11 YKL099C Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Synthetic Lethality
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Positive Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Positive Genetic
URA5 YML106W Major orotate phosphoribosyltransferase (OPRTase) isozyme genetic 1 1 1 Negative Genetic
LRO1 YNR008W Acyltransferase that converts diacylglycerol to triacylglycerol (TGA) genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Positive Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
MCA1 YOR197W Ca2+-dependent cysteine protease genetic 1 1 1 Synthetic Growth Defect
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Positive Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Positive Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Positive Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Positive Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Positive Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Positive Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
RIB5 YBR256C Riboflavin synthase genetic 1 1 1 Negative Genetic
PWP2 YCR057C Conserved 90S pre-ribosomal component genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
NOP7 YGR103W Component of several different pre-ribosomal particles genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 1 1 1 Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
NOP14 YDL148C Nucleolar protein genetic 1 1 1 Negative Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
NTR2 YKR022C Essential protein that forms a dimer with Ntr1p genetic 1 1 1 Negative Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
SRP54 YPR088C Signal recognition particle (SRP) subunit (homolog of mammalian SRP54) genetic 1 1 1 Negative Genetic
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Negative Genetic
NEO1 YIL048W Phospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Negative Genetic
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Negative Genetic
MSL5 YLR116W Component of commitment complex genetic 1 1 1 Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
HEM4 YOR278W Uroporphyrinogen III synthase genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
RPL33A YPL143W Ribosomal 60S subunit protein L33A genetic 1 1 1 Negative Genetic
PRP46 YPL151C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Negative Genetic
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Negative Genetic
YER084W YER084W Protein of unknown function genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
NDE1 YMR145C Mitochondrial external NADH dehydrogenase genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
TYR1 YBR166C Prephenate dehydrogenase involved in tyrosine biosynthesis genetic 1 1 1 Negative Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Negative Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Negative Genetic
RBS1 YDL189W Protein involved in assembly of the RNA Pol III complex genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
YPQ2 YDR352W Putative vacuolar membrane transporter for cationic amino acids genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Negative Genetic
MIL1 YFL034W Predicted lipase genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
MUP1 YGR055W High affinity methionine permease genetic 1 1 1 Negative Genetic
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Negative Genetic
YJL136W-A YJL136W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
LAA1 YJL207C AP-1 accessory protein genetic 1 1 1 Negative Genetic
YJR056C YJR056C Protein of unknown function genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MTC2 YKL098W Protein of unknown function genetic 1 1 1 Negative Genetic
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Negative Genetic
TVP18 YMR071C Integral membrane protein genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YMR247W-A YMR247W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
PRM15 YMR278W Phosphoribomutase genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
PET494 YNR045W Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Negative Genetic
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
PYK2 YOR347C Pyruvate kinase genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Positive Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Dosage Lethality
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex physical 1 1 1 Affinity Capture-Western
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
ACO2 YJL200C Putative mitochondrial aconitase isozyme genetic 1 1 1 Positive Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
CPT1 YNL130C Cholinephosphotransferase physical 1 1 1 PCA
ALF1 YNL148C Alpha-tubulin folding protein genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis physical 1 1 1 PCA
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
BNR1 YIL159W Formin genetic 1 1 1 Positive Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex physical 1 1 1 PCA
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Dosage Growth Defect
ACF2 YLR144C Intracellular beta-1,3-endoglucanase physical 1 1 1 PCA
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Lethality
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
EPO1 YMR124W Protein involved in septin-ER tethering genetic 1 1 1 Negative Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
DAL5 YJR152W Allantoate permease physical 1 1 1 PCA
ATP15 YPL271W Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
CAB4 YGR277C Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) genetic 1 1 1 Negative Genetic
ALD6 YPL061W Cytosolic aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 genetic 1 1 1 Negative Genetic
EGH1 YIR007W Steryl-beta-glucosidase with broad specificity for aglycones genetic 1 1 1 Negative Genetic
ARO2 YGL148W Bifunctional chorismate synthase and flavin reductase genetic 1 1 1 Negative Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Negative Genetic
ARV1 YLR242C Cortical ER protein physical 1 1 1 PCA
EMC4 YGL231C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
COS4 YFL062W Endosomal protein involved in turnover of plasma membrane proteins physical 1 1 1 PCA
ASI1 YMR119W Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Dosage Growth Defect
ASI2 YNL159C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex physical 1 1 1 Affinity Capture-Western
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) physical 1 1 1 PCA
COS8 YHL048W Endosomal protein involved in turnover of plasma membrane proteins physical 1 1 1 PCA
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
EMC10 YDR056C Putative protein of unknown function genetic 1 1 1 Negative Genetic
DPI8 YJL133C-A Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
COS6 YGR295C Endosomal protein involved in turnover of plasma membrane proteins physical 1 1 1 PCA
DLT1 YMR126C Protein of unknown function genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
CIT3 YPR001W Dual specificity mitochondrial citrate and methylcitrate synthase genetic 1 1 1 Negative Genetic
DML1 YMR211W Essential protein involved in mtDNA inheritance genetic 1 1 1 Negative Genetic