Standard name Systematic name Name description Description
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation
Visualize the interactome of SSN2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.178 0.200 0.526
Nucleolus 0.079 NaN NaN
Nucleus 0.882 0.805 0.708
Vac/Vac Memb NaN 0.060 NaN
Cytoplasm NaN NaN 0.058

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus low signal

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SSN2 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme physical 7 3 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex
SRB4 YER022W Subunit of the RNA polymerase II mediator complex physical 4 2 4 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SSN3 YPL042C Component of the RNA polymerase II mediator complex physical 4 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 4 3 3 Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex physical 4 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 3 2 3 Synthetic Rescue, Negative Genetic, Synthetic Rescue
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 3 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 3 3 2 Affinity Capture-Western, Two-hybrid, Affinity Capture-RNA
MIG1 YGL035C Transcription factor involved in glucose repression genetic 3 2 2 Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 2 2 2 Two-hybrid, Affinity Capture-MS
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Positive Genetic, Dosage Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SNF1 YDR477W AMP-activated S/T protein kinase genetic 2 2 2 Dosage Rescue, Synthetic Rescue
GET2 YER083C Subunit of the GET complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 1 2 Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Positive Genetic, Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 1 2 Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 2 1 2 Negative Genetic, Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 2 Positive Genetic, Positive Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 2 Positive Genetic, Positive Genetic
PHO85 YPL031C Cyclin-dependent kinase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex physical 2 1 2 Two-hybrid, Two-hybrid
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 2 1 2 Negative Genetic, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 1 2 Negative Genetic, Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 2 1 2 Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 2 1 2 Negative Genetic, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 2 1 2 Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
DST1 YGL043W General transcription elongation factor TFIIS physical 2 2 1 Two-hybrid, Affinity Capture-Western
RNH1 YMR234W Ribonuclease H1 genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex physical 2 2 1 Affinity Capture-Western, Two-hybrid
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MED1 YPR070W Subunit of the RNA polymerase II mediator complex physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
ADA2 YDR448W Transcription coactivator genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 quantitative mass spectrometry evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) regulation 1 1 1 DNA to cDNA expression microarray evidence
AKR2 YOR034C Ankyrin repeat-containing protein regulation 1 1 1 DNA to cDNA expression microarray evidence
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase regulation 1 1 1 DNA to cDNA expression microarray evidence
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase regulation 1 1 1 DNA to cDNA expression microarray evidence
YGP1 YNL160W Cell wall-related secretory glycoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
NET1 YJL076W Core subunit of the RENT complex regulation 1 1 1 DNA to cDNA expression microarray evidence
CIP1 YPL014W Cyclin-dependent kinase inhibitor regulation 1 1 1 DNA to cDNA expression microarray evidence
YOR225W YOR225W Dubious open reading frame regulation 1 1 1 DNA to cDNA expression microarray evidence
GLK1 YCL040W Glucokinase regulation 1 1 1 DNA to cDNA expression microarray evidence
GAD1 YMR250W Glutamate decarboxylase regulation 1 1 1 DNA to cDNA expression microarray evidence
GSY1 YFR015C Glycogen synthase regulation 1 1 1 DNA to cDNA expression microarray evidence
SPI1 YER150W GPI-anchored cell wall protein involved in weak acid resistance regulation 1 1 1 DNA to cDNA expression microarray evidence
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane regulation 1 1 1 DNA to cDNA expression microarray evidence
GCV3 YAL044C H subunit of the mitochondrial glycine decarboxylase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
PTR2 YKR093W Integral membrane peptide transporter regulation 1 1 1 DNA to cDNA expression microarray evidence
TSL1 YML100W Large subunit of trehalose 6-phosphate synthase/phosphatase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
FIT3 YOR383C Mannoprotein that is incorporated into the cell wall regulation 1 1 1 DNA to cDNA expression microarray evidence
ISU2 YOR226C Mitochondrial protein required for iron-sulfur protein synthesis regulation 1 1 1 DNA to cDNA expression microarray evidence
MMF1 YIL051C Mitochondrial protein required for transamination of isoleucine regulation 1 1 1 DNA to cDNA expression microarray evidence
DDR2 YOL052C-A Multi-stress response protein regulation 1 1 1 DNA to cDNA expression microarray evidence
YHB1 YGR234W Nitric oxide oxidoreductase regulation 1 1 1 DNA to cDNA expression microarray evidence
TPO4 YOR273C Polyamine transporter of the major facilitator superfamily regulation 1 1 1 DNA to cDNA expression microarray evidence
GAT2 YMR136W Protein containing GATA family zinc finger motifs regulation 1 1 1 DNA to cDNA expression microarray evidence
YLR297W YLR297W Protein of unknown function regulation 1 1 1 DNA to cDNA expression microarray evidence
GCV2 YMR189W P subunit of the mitochondrial glycine decarboxylase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
TIR2 YOR010C Putative cell wall mannoprotein regulation 1 1 1 DNA to cDNA expression microarray evidence
GCV1 YDR019C T subunit of the mitochondrial glycine decarboxylase complex regulation 1 1 1 DNA to cDNA expression microarray evidence
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex regulation 1 1 1 qualitative western immunoblotting evidence
GRR1 YJR090C F-box protein component of an SCF ubiquitin-ligase complex regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
NPL6 YMR091C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MUD1 YBR119W U1 snRNP A protein genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Positive Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 1 1 1 Two-hybrid
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-RNA
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Two-hybrid
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Negative Genetic
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Positive Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation physical 1 1 1 Two-hybrid
HTA1 YDR225W Histone H2A genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex genetic 1 1 1 Negative Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Lethality
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Biochemical Activity
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Positive Genetic
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Rescue
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Positive Genetic
PSK1 YAL017W PAS domain-containing serine/threonine protein kinase physical 1 1 1 Two-hybrid
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Phenotypic Suppression
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Growth Defect
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Positive Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
RNQ1 YCL028W [PIN(+)] prion physical 1 1 1 Affinity Capture-Western
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Positive Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Positive Genetic
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Synthetic Rescue
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Dosage Rescue
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RCK1 YGL158W Protein kinase involved in oxidative stress response physical 1 1 1 Affinity Capture-MS
MEH1 YKR007W Subunit of the EGO/GSE complex genetic 1 1 1 Negative Genetic
SOF1 YLL011W Protein required for biogenesis of 40S (small) ribosomal subunit genetic 1 1 1 Negative Genetic
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Positive Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Synthetic Lethality
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Negative Genetic
IRE1 YHR079C Serine-threonine kinase and endoribonuclease genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
SPO1 YNL012W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Negative Genetic
CTL1 YMR180C RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm genetic 1 1 1 Negative Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Positive Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator physical 1 1 1 Affinity Capture-Western
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Phenotypic Suppression
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
RGT1 YKL038W Glucose-responsive transcription factor genetic 1 1 1 Negative Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Synthetic Rescue
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Positive Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Positive Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 1 1 1 Biochemical Activity
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Phenotypic Suppression
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Suppression
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Negative Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
YPL150W YPL150W Protein kinase of unknown cellular role genetic 1 1 1 Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Positive Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Positive Genetic
STP2 YHR006W Transcription factor genetic 1 1 1 Positive Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
THI2 YBR240C Transcriptional activator of thiamine biosynthetic genes genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
YOR131C YOR131C Putative haloacid dehalogenase-like hydrolase genetic 1 1 1 Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
TFC8 YPL007C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
TRI1 YMR233W Non-essential sumoylated protein of unknown function genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
HAP1 YLR256W Zinc finger transcription factor genetic 1 1 1 Synthetic Rescue
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
CAF16 YFL028C Part of evolutionarily-conserved CCR4-NOT regulatory complex physical 1 1 1 Two-hybrid
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Rescue
DAL5 YJR152W Allantoate permease genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase physical 1 1 1 Affinity Capture-MS
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
POM33 YLL023C Transmembrane nucleoporin genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Positive Genetic
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Positive Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
AFT2 YPL202C Iron-regulated transcriptional activator genetic 1 1 1 Negative Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 1 1 1 Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Negative Genetic
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Synthetic Lethality
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Positive Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic