Standard name Systematic name Name description Description
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein Nuclear polyadenylated RNA-binding protein; required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; interacts with DBP2; inhibits the helicase activity of Dbp2; functionally redundant with Yra2p, another REF family member
Visualize the interactome of YRA1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.220 NaN 0.125
Nucleolus 0.253 NaN 0.438
Nucleus 0.912 NaN 0.875

GFP localization & abundance

GFP localization GFP abundance
nucleus no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YRA1 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 12 4 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 11 5 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-MS
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export physical 9 3 8 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
HPR1 YDR138W Subunit of THO/TREX complexes physical 6 3 5 Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 6 3 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 6 2 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 6 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family physical 6 3 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
MFT1 YML062C Subunit of the THO complex physical 5 2 5 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 5 3 4 Negative Genetic, Dosage Rescue, Negative Genetic, Synthetic Rescue, Synthetic Rescue
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 5 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 5 3 3 Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Synthetic Rescue, Synthetic Rescue
PCF11 YDR228C mRNA 3' end processing factor physical 5 2 3 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
KAP123 YER110C Karyopherin beta physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GBP2 YCL011C Poly(A+) RNA-binding protein physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Synthetic Rescue
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 3 3 3 Dosage Rescue, Dosage Growth Defect, Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 3 3 3 Synthetic Lethality, Dosage Growth Defect, Negative Genetic
NPL3 YDR432W RNA-binding protein physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid
HPR1 YDR138W Subunit of THO/TREX complexes genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Dosage Growth Defect
THO2 YNL139C Subunit of the THO complex physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope physical 3 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
YHR127W YHR127W Protein of unknown function physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 3 2 Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement
THP2 YHR167W Subunit of the THO and TREX complexes physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 3 1 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
RRP6 YOR001W Nuclear exosome exonuclease component genetic 2 2 2 Synthetic Lethality, Negative Genetic
MFT1 YML062C Subunit of the THO complex genetic 2 2 2 Synthetic Lethality, Dosage Growth Defect
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 2 2 2 Synthetic Lethality, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Synthetic Lethality, Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 2 2 2 Synthetic Rescue, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NOP2 YNL061W rRNA m5C methyltransferase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
THO2 YNL139C Subunit of the THO complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
LSG1 YGL099W Putative GTPase involved in 60S ribosomal subunit biogenesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ORC1 YML065W Largest subunit of the origin recognition complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 2 1 2 Negative Genetic, Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SAW1 YAL027W 5'- and 3'-flap DNA binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TOP2 YNL088W Topoisomerase II physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PAP2 YOL115W Non-canonical poly(A) polymerase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CTK3 YML112W Gamma subunit of C-terminal domain kinase I physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HRB1 YNL004W Poly(A+) RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PDP3 YLR455W Component of the NuA3b histone acetyltransferase complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) physical 2 2 1 Far Western, Reconstituted Complex
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 2 2 1 Reconstituted Complex, Affinity Capture-Western
DIA2 YOR080W Origin-binding F-box protein physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RRP45 YDR280W Exosome non-catalytic core component physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SAC3 YDR159W mRNA export factor physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
THP1 YOL072W Nuclear pore-associated protein genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
CYC8 YBR112C General transcriptional co-repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPN1 YPR133C Protein involved in RNA polymerase II transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NFI1 YOR156C SUMO E3 ligase regulation 1 1 1 qualitative western immunoblotting evidence
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex regulation 1 1 1 qualitative western immunoblotting evidence
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates regulation 1 1 1 qualitative western immunoblotting evidence
SIZ1 YDR409W SUMO E3 ligase regulation 1 1 1 qualitative western immunoblotting evidence
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex regulation 1 1 1 qualitative western immunoblotting evidence
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-Western
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 1 1 1 Affinity Capture-MS
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
SSF1 YHR066W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
POP8 YBL018C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family physical 1 1 1 Affinity Capture-MS
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
PRP46 YPL151C Member of the NineTeen Complex (NTC) physical 1 1 1 Affinity Capture-MS
SMB1 YER029C Core Sm protein Sm B physical 1 1 1 Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NOC2 YOR206W Protein involved in ribosome biogenesis physical 1 1 1 Affinity Capture-MS
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 Affinity Capture-MS
UTP4 YDR324C Subunit of U3-containing 90S preribosome and SSU processome complexes genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus physical 1 1 1 Affinity Capture-MS
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
RRP7 YCL031C Essential protein involved in rRNA processing and ribosome biogenesis genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
CIC1 YHR052W Essential protein that interacts with proteasome components physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Negative Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Negative Genetic
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 Affinity Capture-MS
MTR4 YJL050W RNA duplex-sensing translocase physical 1 1 1 Affinity Capture-MS
MTR4 YJL050W RNA duplex-sensing translocase genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease physical 1 1 1 Affinity Capture-MS
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase physical 1 1 1 Affinity Capture-MS
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-MS
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Lethality
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP45 YDR280W Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-Western
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex physical 1 1 1 Affinity Capture-MS
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
TEX1 YNL253W Protein involved in mRNA export physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Synthetic Growth Defect
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Negative Genetic
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
CFT2 YLR115W Subunit of the mRNA cleavage and polyadenlylation factor (CPF) physical 1 1 1 Affinity Capture-MS
CFT1 YDR301W RNA-binding subunit of the mRNA cleavage and polyadenylation factor physical 1 1 1 Affinity Capture-MS
PFS2 YNL317W Integral subunit of the pre-mRNA CPF complex physical 1 1 1 Affinity Capture-MS
IMD2 YHR216W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing physical 1 1 1 Affinity Capture-MS
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) physical 1 1 1 Affinity Capture-MS
TSR2 YLR435W Protein with a potential role in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex physical 1 1 1 Affinity Capture-MS
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Affinity Capture-MS
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Affinity Capture-MS
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) physical 1 1 1 Affinity Capture-MS
SDA1 YGR245C Protein required for actin organization and passage through Start physical 1 1 1 Affinity Capture-MS
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) physical 1 1 1 Reconstituted Complex
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome physical 1 1 1 Affinity Capture-MS
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
EMP24 YGL200C Component of the p24 complex physical 1 1 1 Affinity Capture-MS
ERP2 YAL007C Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase physical 1 1 1 Affinity Capture-MS
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex physical 1 1 1 Affinity Capture-MS
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
BDF2 YDL070W Protein involved in transcription initiation physical 1 1 1 Affinity Capture-MS
IRR1 YIL026C Subunit of the cohesin complex physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Synthetic Rescue
UTP6 YDR449C Nucleolar protein physical 1 1 1 Affinity Capture-MS
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Affinity Capture-MS
MRPL28 YDR462W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Affinity Capture-MS
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 1 1 1 Affinity Capture-MS
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase physical 1 1 1 Affinity Capture-MS
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping physical 1 1 1 Affinity Capture-MS
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
PBP2 YBR233W RNA binding protein physical 1 1 1 Affinity Capture-MS
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
PRP28 YDR243C Pre-mRNA splicing factor physical 1 1 1 Affinity Capture-MS
PRP4 YPR178W Splicing factor physical 1 1 1 Affinity Capture-MS
LEA1 YPL213W Component of U2 snRNP complex physical 1 1 1 Affinity Capture-MS
PRP6 YBR055C Splicing factor physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Negative Genetic
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase physical 1 1 1 Affinity Capture-MS
RAD51 YER095W Strand exchange protein genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein physical 1 1 1 Affinity Capture-MS
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ROX3 YBL093C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Synthetic Growth Defect
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Negative Genetic
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members physical 1 1 1 Affinity Capture-MS
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation physical 1 1 1 Affinity Capture-MS
SGN1 YIR001C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-MS
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 Affinity Capture-MS
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
HRK1 YOR267C Protein kinase physical 1 1 1 Affinity Capture-MS
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SPE3 YPR069C Spermidine synthase genetic 1 1 1 Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex physical 1 1 1 Affinity Capture-Western
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex physical 1 1 1 Affinity Capture-Western
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Rescue
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Rescue
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MSH4 YFL003C Protein involved in meiotic recombination genetic 1 1 1 Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Affinity Capture-MS
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) physical 1 1 1 Affinity Capture-MS
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Negative Genetic
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 1 1 1 Affinity Capture-MS
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Reconstituted Complex
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Affinity Capture-MS
RVS161 YCR009C Amphiphysin-like lipid raft protein physical 1 1 1 Affinity Capture-MS
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
ELA1 YNL230C Elongin A physical 1 1 1 Affinity Capture-MS
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
GDB1 YPR184W Glycogen debranching enzyme genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p physical 1 1 1 Affinity Capture-MS
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
AFR1 YDR085C Protein required for pheromone-induced projection (shmoo) formation physical 1 1 1 Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 1 1 1 Affinity Capture-MS
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Lethality
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
NOP13 YNL175C Nucleolar protein found in preribosomal complexes physical 1 1 1 Affinity Capture-MS
SKI2 YLR398C Ski complex component and putative RNA helicase physical 1 1 1 Affinity Capture-MS
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Lethality
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases physical 1 1 1 Affinity Capture-MS
HMG2 YLR450W HMG-CoA reductase physical 1 1 1 Affinity Capture-MS
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
GDT1 YBR187W Calcium and manganese transporter with higher affinity for Ca2+ physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E physical 1 1 1 Affinity Capture-MS
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Negative Genetic
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins physical 1 1 1 Affinity Capture-MS
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p physical 1 1 1 Affinity Capture-MS
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase physical 1 1 1 Affinity Capture-MS
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Affinity Capture-MS
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Negative Genetic
ATG16 YMR159C Conserved protein involved in autophagy genetic 1 1 1 Negative Genetic
CIN4 YMR138W GTP-binding protein involved in beta-tubulin (Tub2p) folding physical 1 1 1 Two-hybrid
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Negative Genetic
CUP2 YGL166W Copper-binding transcription factor physical 1 1 1 Affinity Capture-MS
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Affinity Capture-MS
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
ATG27 YJL178C Type I membrane protein involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein physical 1 1 1 Affinity Capture-MS
PFS1 YHR185C Sporulation protein required for prospore membrane formation physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Negative Genetic
SYO1 YDL063C Transport adaptor or symportin physical 1 1 1 Two-hybrid
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Positive Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
IPL1 YPL209C Aurora kinase of chromosomal passenger complex physical 1 1 1 Affinity Capture-MS
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) physical 1 1 1 Affinity Capture-Western
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Positive Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
HOT1 YMR172W Transcription factor for glycerol biosynthetic genes physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-Western
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Synthetic Lethality
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex physical 1 1 1 Affinity Capture-MS
ARP6 YLR085C Actin-related protein that binds nucleosomes physical 1 1 1 Affinity Capture-MS
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
DAL81 YIR023W Positive regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex physical 1 1 1 Affinity Capture-MS
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
APN1 YKL114C Major apurinic/apyrimidinic endonuclease physical 1 1 1 Affinity Capture-MS
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Synthetic Lethality
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Negative Genetic
MTR2 YKL186C mRNA transport regulator physical 1 1 1 Affinity Capture-MS
PRK1 YIL095W Ser/Thr protein kinase physical 1 1 1 Affinity Capture-MS
RRN3 YKL125W Protein required for transcription of rDNA by RNA polymerase I genetic 1 1 1 Negative Genetic
RTG2 YGL252C Sensor of mitochondrial dysfunction physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Affinity Capture-MS
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
RSM22 YKL155C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
RSM18 YER050C Mitochondrial ribosomal protein of the small subunit physical 1 1 1 Affinity Capture-MS
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) physical 1 1 1 Affinity Capture-Western
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Positive Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Negative Genetic
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
SPC34 YKR037C Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Affinity Capture-MS
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p physical 1 1 1 Affinity Capture-MS
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
ESC1 YMR219W Protein involved in telomeric silencing genetic 1 1 1 Negative Genetic
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase physical 1 1 1 Affinity Capture-MS
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase physical 1 1 1 Affinity Capture-MS
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Negative Genetic
SSA4 YER103W Heat shock protein that is highly induced upon stress physical 1 1 1 Affinity Capture-RNA
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
MSB3 YNL293W Rab GTPase-activating protein physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase physical 1 1 1 Affinity Capture-MS
PRI1 YIR008C Subunit of DNA primase physical 1 1 1 Affinity Capture-MS
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) physical 1 1 1 Affinity Capture-MS
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase physical 1 1 1 Affinity Capture-MS
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
MSL5 YLR116W Component of commitment complex physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
DID2 YKR035W-A Class E protein of the vacuolar protein-sorting (Vps) pathway genetic 1 1 1 Positive Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP physical 1 1 1 Affinity Capture-MS
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
YRO2 YBR054W Protein with a putative role in response to acid stress physical 1 1 1 Affinity Capture-MS
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor physical 1 1 1 Affinity Capture-MS
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
YSA1 YBR111C Nudix hydrolase family member with ADP-ribose pyrophosphatase activity genetic 1 1 1 Negative Genetic
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
PAR32 YDL173W Low complexity protein physical 1 1 1 Affinity Capture-MS
YLL054C YLL054C Putative protein of unknown function with similarity to Pip2p physical 1 1 1 Affinity Capture-MS
RPL13A YDL082W Ribosomal 60S subunit protein L13A physical 1 1 1 Affinity Capture-MS
RPL14B YHL001W Ribosomal 60S subunit protein L14B physical 1 1 1 Affinity Capture-MS
SNU13 YEL026W RNA binding protein physical 1 1 1 Affinity Capture-MS
TAO3 YIL129C Component of the RAM signaling network physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Negative Genetic
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PIH1 YHR034C Component of the conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
BUD22 YMR014W Protein required for rRNA maturation and ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-Western
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-MS
JHD2 YJR119C JmjC domain family histone demethylase physical 1 1 1 Affinity Capture-MS
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
TRM8 YDL201W Catalytic subunit of a tRNA methyltransferase complex physical 1 1 1 Affinity Capture-MS
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair physical 1 1 1 Affinity Capture-MS
IFA38 YBR159W Microsomal beta-keto-reductase physical 1 1 1 Affinity Capture-MS
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B genetic 1 1 1 Negative Genetic
PBP4 YDL053C Pbp1p binding protein physical 1 1 1 Affinity Capture-MS
YCR043C YCR043C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SRP14 YDL092W Signal recognition particle (SRP) subunit physical 1 1 1 Affinity Capture-MS
NTH1 YDR001C Neutral trehalase, degrades trehalose physical 1 1 1 Affinity Capture-MS
UME6 YDR207C Rpd3L histone deacetylase complex subunit physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Synthetic Lethality
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein physical 1 1 1 Affinity Capture-MS
SRP40 YKR092C Nucleolar serine-rich protein genetic 1 1 1 Negative Genetic
JIP4 YDR475C Protein of unknown function physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-MS
EDC2 YER035W RNA-binding protein that directly activates mRNA decapping physical 1 1 1 Affinity Capture-MS
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase physical 1 1 1 Affinity Capture-MS
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase physical 1 1 1 Affinity Capture-MS
NPY1 YGL067W NADH diphosphatase (pyrophosphatase) physical 1 1 1 Affinity Capture-MS
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes physical 1 1 1 Affinity Capture-MS
MSC7 YHR039C Protein of unknown function physical 1 1 1 Affinity Capture-MS
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
ORC4 YPR162C Subunit of the origin recognition complex (ORC) physical 1 1 1 Affinity Capture-MS
YIL161W YIL161W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase physical 1 1 1 Affinity Capture-MS
URB2 YJR041C Protein required for normal metabolism of the rRNA primary transcript physical 1 1 1 Affinity Capture-MS
THP3 YPR045C Protein that may have a role in transcription elongation physical 1 1 1 Affinity Capture-MS
YKL075C YKL075C Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YKL075C YKL075C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase physical 1 1 1 Affinity Capture-MS
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p physical 1 1 1 Affinity Capture-MS
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 physical 1 1 1 Affinity Capture-MS
RPS25B YLR333C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
VAC14 YLR386W Enzyme regulator physical 1 1 1 Affinity Capture-MS
PKR1 YMR123W V-ATPase assembly factor physical 1 1 1 Affinity Capture-MS
SFB2 YNL049C Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
MRPL22 YNL177C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Affinity Capture-MS
MSE1 YOL033W Mitochondrial glutamyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
SAS5 YOR213C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) physical 1 1 1 Affinity Capture-MS
FCY1 YPR062W Cytosine deaminase genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Negative Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL43A YPR043W Ribosomal 60S subunit protein L43A genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Positive Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Positive Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
SCD6 YPR129W Repressor of translation initiation physical 1 1 1 Affinity Capture-MS
SCD6 YPR129W Repressor of translation initiation genetic 1 1 1 Negative Genetic
THO1 YER063W Conserved nuclear RNA-binding protein physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
SWT1 YOR166C RNA endoribonuclease involved in perinuclear mRNP quality control physical 1 1 1 Affinity Capture-Western
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
RTC1 YOL138C Subunit of SEACAT, a subcomplex of the SEA complex physical 1 1 1 Affinity Capture-MS
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
RBS1 YDL189W Protein involved in assembly of the RNA Pol III complex physical 1 1 1 Affinity Capture-MS
CEM1 YER061C Mitochondrial beta-keto-acyl synthase genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
MYG1 YER156C Protein involved in mitochondrial function genetic 1 1 1 Negative Genetic
DSC2 YOL073C Multi-transmembrane subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SDH5 YOL071W Protein required for flavinylation of Sdh1p genetic 1 1 1 Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Negative Genetic
NFG1 YLR042C Cell wall protein of unknown function genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
TRF5 YNL299W Non-canonical poly(A) polymerase physical 1 1 1 Affinity Capture-MS
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
ECM8 YBR076W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
URA4 YLR420W Dihydroorotase genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
YKR041W YKR041W Protein of unknown function genetic 1 1 1 Negative Genetic
YPL068C YPL068C Protein of unknown function genetic 1 1 1 Negative Genetic