| CTF18 |
YMR078C |
Subunit of a complex with Ctf8p |
genetic |
11 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF8 |
YHR191C |
Subunit of a complex with Ctf18p |
genetic |
11 |
3 |
9 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CHL4 |
YDR254W |
Outer kinetochore protein required for chromosome stability |
genetic |
11 |
3 |
8 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
11 |
3 |
8 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GIM3 |
YNL153C |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN1 |
YOR349W |
Tubulin folding factor D involved in beta-tubulin (Tub2p) folding |
genetic |
10 |
3 |
8 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
10 |
2 |
8 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| YKE2 |
YLR200W |
Subunit of the heterohexameric Gim/prefoldin protein complex |
genetic |
10 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CIN8 |
YEL061C |
Bipolar kinesin motor protein |
genetic |
9 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Negative Genetic |
| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
9 |
3 |
9 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic |
| MCM22 |
YJR135C |
Outer kinetochore protein and component of the Ctf3 subcomplex |
genetic |
9 |
3 |
7 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DCC1 |
YCL016C |
Subunit of a complex with Ctf8p and Ctf18p |
genetic |
9 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
physical |
9 |
6 |
5 |
Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Reconstituted Complex, Co-purification, Affinity Capture-Western |
| GIM4 |
YEL003W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
8 |
3 |
8 |
Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF3 |
YLR381W |
Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p |
genetic |
8 |
3 |
7 |
Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HCM1 |
YCR065W |
Forkhead transcription factor |
genetic |
8 |
3 |
7 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF19 |
YPL018W |
Outer kinetochore protein, needed for accurate chromosome segregation |
genetic |
8 |
2 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| TUB3 |
YML124C |
Alpha-tubulin |
genetic |
8 |
3 |
6 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SLK19 |
YOR195W |
Kinetochore-associated protein |
genetic |
8 |
3 |
6 |
Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MCM21 |
YDR318W |
Component of the kinetochore sub-complex COMA |
genetic |
8 |
2 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
8 |
2 |
5 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CHL1 |
YPL008W |
Probable DNA helicase |
genetic |
7 |
3 |
7 |
Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| GIM5 |
YML094W |
Subunit of the heterohexameric cochaperone prefoldin complex |
genetic |
7 |
2 |
7 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CTF4 |
YPR135W |
Chromatin-associated protein |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
| PAC10 |
YGR078C |
Part of the heteromeric co-chaperone GimC/prefoldin complex |
genetic |
7 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
7 |
3 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic |
| MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
genetic |
6 |
3 |
5 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
6 |
3 |
5 |
Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
6 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
genetic |
6 |
2 |
4 |
Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| NUP133 |
YKR082W |
Subunit of Nup84p subcomplex of nuclear pore complex (NPC) |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| IRC15 |
YPL017C |
Microtubule associated protein |
genetic |
6 |
2 |
4 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
5 |
2 |
5 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
physical |
5 |
3 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Co-localization |
| IML3 |
YBR107C |
Outer kinetochore protein and component of the Ctf19 complex |
genetic |
5 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
5 |
2 |
4 |
Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
physical |
5 |
1 |
4 |
Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western |
| CDC7 |
YDL017W |
S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) |
genetic |
4 |
2 |
4 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic |
| PAC2 |
YER007W |
Microtubule effector required for tubulin heterodimer formation |
genetic |
4 |
2 |
4 |
Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
4 |
3 |
3 |
Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression |
| AME1 |
YBR211C |
Essential kinetochore protein associated with microtubules and SPBs |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| VPS72 |
YDR485C |
Htz1p-binding component of the SWR1 complex |
genetic |
4 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SAC3 |
YDR159W |
mRNA export factor |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| DAD1 |
YDR016C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
4 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SWR1 |
YDR334W |
Swi2/Snf2-related ATPase |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Negative Genetic, Synthetic Growth Defect |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
3 |
3 |
3 |
Synthetic Growth Defect, Synthetic Lethality, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
3 |
2 |
3 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| DIA2 |
YOR080W |
Origin-binding F-box protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| ARP6 |
YLR085C |
Actin-related protein that binds nucleosomes |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Growth Defect, Negative Genetic |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Negative Genetic, Negative Genetic |
| TUB2 |
YFL037W |
Beta-tubulin |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic |
| VPS71 |
YML041C |
Nucleosome-binding component of the SWR1 complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| PFD1 |
YJL179W |
Subunit of heterohexameric prefoldin |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| RPN11 |
YFR004W |
Metalloprotease subunit of 19S regulatory particle |
genetic |
3 |
2 |
3 |
Negative Genetic, Synthetic Lethality, Negative Genetic |
| NUF2 |
YOL069W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
2 |
3 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| DAM1 |
YGR113W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SHP1 |
YBL058W |
UBX domain-containing substrate adaptor for Cdc48p |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SCC2 |
YDR180W |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
genetic |
3 |
2 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality |
| NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
physical |
3 |
2 |
2 |
Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex |
| NSL1 |
YPL233W |
Essential component of the MIND kinetochore complex |
genetic |
3 |
2 |
2 |
Synthetic Lethality, Negative Genetic, Negative Genetic |
| HHF1 |
YBR009C |
Histone H4 |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PSF1 |
YDR013W |
Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PEX4 |
YGR133W |
Peroxisomal ubiquitin conjugating enzyme |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| PBS2 |
YJL128C |
MAP kinase kinase of the HOG signaling pathway |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| MSA1 |
YOR066W |
Activator of G1-specific transcription factors MBF and SBF |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| NDC80 |
YIL144W |
Component of the kinetochore-associated Ndc80 complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SPC98 |
YNL126W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SGT1 |
YOR057W |
Cochaperone protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HPF1 |
YOL155C |
Haze-protective mannoprotein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| APQ12 |
YIL040W |
Nuclear envelope/ER integral membrane protein |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence |
| CEF1 |
YMR213W |
Essential splicing factor |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| DSN1 |
YIR010W |
Essential component of the outer kinetochore MIND complex |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| ELP2 |
YGR200C |
Subunit of Elongator complex |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| CEP3 |
YMR168C |
Essential kinetochore protein |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| SWC3 |
YAL011W |
Protein of unknown function |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SSE1 |
YPL106C |
ATPase component of heat shock protein Hsp90 chaperone complex |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| VPS64 |
YDR200C |
Protein required for cytoplasm to vacuole targeting of proteins |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| YBP2 |
YGL060W |
Central kinetochore associated protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| RPC40 |
YPR110C |
RNA polymerase subunit AC40 |
genetic |
2 |
2 |
2 |
Negative Genetic, Synthetic Lethality |
| SMC3 |
YJL074C |
Subunit of the multiprotein cohesin complex |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Negative Genetic |
| MCM10 |
YIL150C |
Essential chromatin-associated protein |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Rescue |
| TUB4 |
YLR212C |
Gamma-tubulin |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Synthetic Growth Defect |
| TOP2 |
YNL088W |
Topoisomerase II |
genetic |
2 |
2 |
2 |
Synthetic Lethality, Negative Genetic |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Negative Genetic |
| SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
2 |
2 |
2 |
Synthetic Growth Defect, Phenotypic Suppression |
| TAF11 |
YML015C |
TFIID subunit (40 kDa) |
genetic |
2 |
2 |
2 |
Negative Genetic, Positive Genetic |
| KAP95 |
YLR347C |
Karyopherin beta |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC45 |
YLR103C |
DNA replication initiation factor |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| INO4 |
YOL108C |
Transcription factor involved in phospholipid synthesis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ATG17 |
YLR423C |
Scaffold protein responsible for phagophore assembly site organization |
physical |
2 |
1 |
2 |
Two-hybrid, Two-hybrid |
| GAL7 |
YBR018C |
Galactose-1-phosphate uridyl transferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC15 |
YAR019C |
Hippo-like kinase of the Mitotic Exit Network |
genetic |
2 |
1 |
2 |
Phenotypic Enhancement, Phenotypic Enhancement |
| DPB11 |
YJL090C |
DNA replication initiation protein |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DUO1 |
YGL061C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| CDC21 |
YOR074C |
Thymidylate synthase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MPS2 |
YGL075C |
Essential membrane protein localized at nuclear envelope and SPBs |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| SPC34 |
YKR037C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| UME6 |
YDR207C |
Rpd3L histone deacetylase complex subunit |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SFI1 |
YLL003W |
Centrin (Cdc31p)-binding protein required for SPB duplication |
genetic |
2 |
1 |
2 |
Synthetic Lethality, Synthetic Lethality |
| PRP22 |
YER013W |
DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SLX5 |
YDL013W |
Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| PPT2 |
YPL148C |
Phosphopantetheine:protein transferase (PPTase) |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CBC2 |
YPL178W |
Small subunit of the heterodimeric cap binding complex with Sto1p |
genetic |
2 |
2 |
1 |
Synthetic Growth Defect, Phenotypic Suppression |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Reconstituted Complex |
| ELG1 |
YOR144C |
Subunit of an alternative replication factor C complex |
genetic |
2 |
2 |
1 |
Negative Genetic, Positive Genetic |
| ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
2 |
2 |
1 |
Dosage Rescue, Phenotypic Suppression |
| ESA1 |
YOR244W |
Catalytic subunit of the histone acetyltransferase complex (NuA4) |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| COG5 |
YNL051W |
Component of the conserved oligomeric Golgi complex |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
2 |
1 |
1 |
Synthetic Lethality, Synthetic Lethality |
| MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| SSB1 |
YDL229W |
Cytoplasmic ATPase that is a ribosome-associated molecular chaperone |
physical |
2 |
1 |
1 |
Affinity Capture-MS, Affinity Capture-MS |
| MPS3 |
YJL019W |
Nuclear envelope protein |
genetic |
2 |
1 |
1 |
Synthetic Growth Defect, Synthetic Growth Defect |
| SPC19 |
YDR201W |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| ROX1 |
YPR065W |
Heme-dependent repressor of hypoxic genes |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| IXR1 |
YKL032C |
Transcriptional repressor that regulates hypoxic genes during normoxia |
regulation |
1 |
1 |
1 |
DNA to cDNA expression microarray evidence |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC40 |
YDR364C |
Pre-mRNA splicing factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CLF1 |
YLR117C |
Member of the NineTeen Complex (NTC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GWT1 |
YJL091C |
Protein involved in the inositol acylation of GlcN-PI |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IKI3 |
YLR384C |
Subunit of Elongator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KAP123 |
YER110C |
Karyopherin beta |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRE1 |
YDL074C |
E3 ubiquitin ligase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BMH1 |
YER177W |
14-3-3 protein, major isoform |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HCA4 |
YJL033W |
DEAD box RNA helicase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LRP1 |
YHR081W |
Nuclear exosome-associated nucleic acid binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DST1 |
YGL043W |
General transcription elongation factor TFIIS |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| GCD2 |
YGR083C |
Delta subunit of the translation initiation factor eIF2B |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| LSG1 |
YGL099W |
Putative GTPase involved in 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APL6 |
YGR261C |
Beta3-like subunit of the yeast AP-3 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BDF1 |
YLR399C |
BET family transcriptional regulator |
physical |
1 |
1 |
1 |
Two-hybrid |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BET3 |
YKR068C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CDC10 |
YCR002C |
Component of the septin ring, required for cytokinesis |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
physical |
1 |
1 |
1 |
Two-hybrid |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CNS1 |
YBR155W |
TPR-containing co-chaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ENP1 |
YBR247C |
Protein associated with U3 and U14 snoRNAs |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
physical |
1 |
1 |
1 |
Two-hybrid |
| HRT1 |
YOL133W |
RING-H2 domain core subunit of multiple ubiquitin ligase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HHF2 |
YNL030W |
Histone H4 |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ARB1 |
YER036C |
ATPase of the ATP-binding cassette (ABC) family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DIB1 |
YPR082C |
17-kDa component of the U4/U6aU5 tri-snRNP |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CSE2 |
YNR010W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HDA3 |
YPR179C |
Subunit of HDA1 histone deacetylase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CMD1 |
YBR109C |
Calmodulin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| INO80 |
YGL150C |
Nucleosome spacing factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| GCN20 |
YFR009W |
Positive regulator of the Gcn2p kinase activity |
physical |
1 |
1 |
1 |
Two-hybrid |
| CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EFB1 |
YAL003W |
Translation elongation factor 1 beta |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DIM1 |
YPL266W |
Essential 18S rRNA dimethylase (dimethyladenosine transferase) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CAB5 |
YDR196C |
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CPR6 |
YLR216C |
Peptidyl-prolyl cis-trans isomerase (cyclophilin) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUB2 |
YMR055C |
Mitotic exit network regulator |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| KOG1 |
YHR186C |
Subunit of TORC1 |
physical |
1 |
1 |
1 |
Two-hybrid |
| GET2 |
YER083C |
Subunit of the GET complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DYN2 |
YDR424C |
Cytoplasmic light chain dynein, microtubule motor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ERG10 |
YPL028W |
Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FUM1 |
YPL262W |
Fumarase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC20 |
YGL116W |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
physical |
1 |
1 |
1 |
Two-hybrid |
| GPN3 |
YLR243W |
Putative GTPase with a role in biogenesis of RNA pol II and polIII |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC4 |
YFL009W |
F-box protein required for both the G1/S and G2/M phase transitions |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CTF13 |
YMR094W |
Subunit of the CBF3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HIR1 |
YBL008W |
Subunit of the HIR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HHT1 |
YBR010W |
Histone H3 |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| IRA1 |
YBR140C |
GTPase-activating protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
1 |
1 |
1 |
Positive Genetic |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ESS1 |
YJR017C |
Peptidylprolyl-cis/trans-isomerase (PPIase) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DAD2 |
YKR083C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ARH1 |
YDR376W |
Oxidoreductase of the mitochondrial inner membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ENT3 |
YJR125C |
Protein containing an N-terminal epsin-like domain |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GZF3 |
YJL110C |
GATA zinc finger protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| ATG39 |
YLR312C |
Transmembrane receptor with a role in nucleophagy |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CSM3 |
YMR048W |
Replication fork associated factor |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| ASK1 |
YKL052C |
Essential subunit of the Dam1 complex (aka DASH complex) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| APC5 |
YOR249C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| APC11 |
YDL008W |
Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC4 |
YDR118W |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| COG6 |
YNL041C |
Component of the conserved oligomeric Golgi complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| AMD1 |
YML035C |
AMP deaminase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CET1 |
YPL228W |
RNA 5'-triphosphatase involved in mRNA 5' capping |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CDC31 |
YOR257W |
Calcium-binding component of the spindle pole body (SPB) half-bridge |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DBP5 |
YOR046C |
Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP53 |
YMR153W |
FG-nucleoporin component of central core of nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
physical |
1 |
1 |
1 |
Two-hybrid |
| SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| MPS1 |
YDL028C |
Dual-specificity kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NUP60 |
YAR002W |
FG-nucleoporin component of central core of the nuclear pore complex |
physical |
1 |
1 |
1 |
Co-localization |
| MLP2 |
YIL149C |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Co-localization |
| MLP1 |
YKR095W |
Myosin-like protein associated with the nuclear envelope |
physical |
1 |
1 |
1 |
Co-localization |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
physical |
1 |
1 |
1 |
Two-hybrid |
| MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
physical |
1 |
1 |
1 |
Co-localization |
| MTW1 |
YAL034W-A |
Essential component of the MIND kinetochore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MUM2 |
YBR057C |
Protein essential for meiotic DNA replication and sporulation |
physical |
1 |
1 |
1 |
Two-hybrid |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| TSC11 |
YER093C |
Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPT6 |
YGL048C |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MPS2 |
YGL075C |
Essential membrane protein localized at nuclear envelope and SPBs |
physical |
1 |
1 |
1 |
Two-hybrid |
| YAP1802 |
YGR241C |
Protein of the AP180 family, involved in clathrin cage assembly |
physical |
1 |
1 |
1 |
Two-hybrid |
| NOT3 |
YIL038C |
Component of the CCR4-NOT core complex, involved in mRNA decapping |
physical |
1 |
1 |
1 |
Two-hybrid |
| MDV1 |
YJL112W |
Peripheral protein of cytosolic face of mitochondrial outer membrane |
physical |
1 |
1 |
1 |
Two-hybrid |
| SMY1 |
YKL079W |
Kinesin-like myosin passenger-protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| YKT6 |
YKL196C |
Vesicle membrane protein (v-SNARE) with acyltransferase activity |
physical |
1 |
1 |
1 |
Two-hybrid |
| STB2 |
YMR053C |
Protein that interacts with Sin3p in a two-hybrid assay |
physical |
1 |
1 |
1 |
Two-hybrid |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
1 |
1 |
1 |
Two-hybrid |
| MPD2 |
YOL088C |
Member of the protein disulfide isomerase (PDI) family |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
physical |
1 |
1 |
1 |
Two-hybrid |
| RPT5 |
YOR117W |
ATPase of the 19S regulatory particle of the 26S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Two-hybrid |
| SPP1 |
YPL138C |
Subunit of COMPASS (Set1C) |
physical |
1 |
1 |
1 |
Two-hybrid |
| NIP100 |
YPL174C |
Large subunit of the dynactin complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| YPL216W |
YPL216W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| MCM16 |
YPR046W |
Component of the Ctf19 complex and the COMA subcomplex |
physical |
1 |
1 |
1 |
Two-hybrid |
| SBP1 |
YHL034C |
Protein that binds eIF4G and has a role in repression of translation |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| SPC105 |
YGL093W |
Subunit of a kinetochore-microtubule binding complex |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| PUF3 |
YLL013C |
Protein of the mitochondrial outer surface |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| RPC82 |
YPR190C |
RNA polymerase III subunit C82 |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| MUS81 |
YDR386W |
Subunit of structure-specific Mms4p-Mus81p endonuclease |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| NUP120 |
YKL057C |
Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MDM20 |
YOL076W |
Non-catalytic subunit of the NatB N-terminal acetyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PHO80 |
YOL001W |
Cyclin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PPA2 |
YMR267W |
Mitochondrial inorganic pyrophosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RML2 |
YEL050C |
Mitochondrial ribosomal protein of the large subunit (L2) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RSM24 |
YDR175C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RSN1 |
YMR266W |
Membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SIT4 |
YDL047W |
Ceramide-activated, type 2A-related serine-threonine phosphatase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SNF4 |
YGL115W |
Activating gamma subunit of the AMP-activated Snf1p kinase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SNF7 |
YLR025W |
One of four subunits of the ESCRT-III complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPT4 |
YGR063C |
Spt4p/5p (DSIF) transcription elongation factor complex subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPT10 |
YJL127C |
Histone H3 acetylase with a role in transcriptional regulation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PAP2 |
YOL115W |
Non-canonical poly(A) polymerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YLR287C |
YLR287C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIM1 |
YCR028C-A |
ssDNA-binding protein essential for mitochondrial genome maintenance |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NPL6 |
YMR091C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| THP1 |
YOL072W |
Nuclear pore-associated protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SOD1 |
YJR104C |
Cytosolic copper-zinc superoxide dismutase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TAF7 |
YMR227C |
TFIID subunit (67 kDa) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SUS1 |
YBR111W-A |
Global transcriptional regulator, component of SAGA, TREX-2 complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SGO1 |
YOR073W |
Component of the spindle checkpoint |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PPG1 |
YNR032W |
Serine protein phosphatase involved in formation of FAR complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NUM1 |
YDR150W |
Protein required for nuclear migration |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| PDR8 |
YLR266C |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSN2 |
YDR443C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT3 |
YDR392W |
Subunit of the SAGA and SAGA-like transcriptional regulatory complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTF1 |
YGL244W |
Subunit of RNAPII-associated chromatin remodeling Paf1 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| VMS1 |
YDR049W |
Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SNT1 |
YCR033W |
Set3C histone deacetylase scaffold |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PHO23 |
YNL097C |
Component of the Rpd3L histone deacetylase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SMC2 |
YFR031C |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| VPH2 |
YKL119C |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RSC3 |
YDR303C |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| TIM12 |
YBR091C |
Essential protein of the inner mitochondrial membrane |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SUP45 |
YBR143C |
Polypeptide release factor (eRF1) in translation termination |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIB7 |
YBR153W |
Diaminohydroxyphoshoribosylaminopyrimidine deaminase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPB5 |
YBR154C |
RNA polymerase subunit ABC27 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TRS20 |
YBR254C |
Core component of transport protein particle (TRAPP) complexes I-III |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RIB5 |
YBR256C |
Riboflavin synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TSC10 |
YBR265W |
3-ketosphinganine reductase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TIM22 |
YDL217C |
Essential core component of mitochondrial TIM22 complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TPI1 |
YDR050C |
Triose phosphate isomerase, abundant glycolytic enzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAF10 |
YDR167W |
Subunit (145 kDa) of TFIID and SAGA complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MSS4 |
YDR208W |
Phosphatidylinositol-4-phosphate 5-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRP42 |
YDR235W |
U1 snRNP protein involved in splicing |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SEC26 |
YDR238C |
Essential beta-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SRP101 |
YDR292C |
Signal recognition particle (SRP) receptor alpha subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PMI40 |
YER003C |
Mannose-6-phosphate isomerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRE1 |
YER012W |
Beta 4 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPN3 |
YER021W |
Essential non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MNP1 |
YGL068W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NBP35 |
YGL091C |
Essential cytoplasmic iron-sulfur cluster binding protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SRM1 |
YGL097W |
Nucleotide exchange factor for Gsp1p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| USE1 |
YGL098W |
Essential SNARE protein localized to the ER |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRP43 |
YGL120C |
RNA helicase in the DEAH-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRP18 |
YGR006W |
Splicing factor and component of snRNP U5 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMD1 |
YGR074W |
Core Sm protein Sm D1 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PRP31 |
YGR091W |
Splicing factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPT6 |
YGR116W |
Nucleosome remodeling protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ZPR1 |
YGR211W |
Essential protein with two zinc fingers |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TIM10 |
YHR005C-A |
Essential protein of the mitochondrial intermembrane space |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RRP4 |
YHR069C |
Exosome non-catalytic core component |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ORC6 |
YHR118C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPB3 |
YIL021W |
RNA polymerase II third largest subunit B44 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NUP159 |
YIL115C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSL2 |
YIL143C |
Component of RNA polymerase transcription factor TFIIH holoenzyme |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAD2 |
YJL035C |
Subunit of tRNA-specific adenosine-34 deaminase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SNU114 |
YKL173W |
GTPase component of U5 snRNP involved in mRNA splicing via spliceosome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MTR2 |
YKL186C |
mRNA transport regulator |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SDS22 |
YKL193C |
Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPS31 |
YLR167W |
Fusion protein cleaved to yield ribosomal protein S31 and ubiquitin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| YCS4 |
YLR272C |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MCM5 |
YLR274W |
Component of the Mcm2-7 hexameric helicase complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| STT4 |
YLR305C |
Phosphatidylinositol-4-kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| UTP21 |
YLR409C |
Subunit of U3-containing 90S preribosome and SSU processome complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ORC1 |
YML065W |
Largest subunit of the origin recognition complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TAF13 |
YML098W |
TFIID subunit (19 kDa) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MCM1 |
YMR043W |
Transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TIF11 |
YMR260C |
Translation initiation factor eIF1A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PSE1 |
YMR308C |
Karyopherin/importin that interacts with the nuclear pore complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NOP2 |
YNL061W |
rRNA m5C methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PGA1 |
YNL158W |
Essential component of GPI-mannosyltransferase II |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPL42A |
YNL162W |
Ribosomal 60S subunit protein L42A |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| POP1 |
YNL221C |
Subunit of RNase MRP, nuclear RNase P and telomerase complexes |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SUI1 |
YNL244C |
Translation initiation factor eIF1 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NOP8 |
YOL144W |
Nucleolar protein required for 60S ribosomal subunit biogenesis |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SLD7 |
YOR060C |
Protein with a role in chromosomal DNA replication |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPB2 |
YOR151C |
RNA polymerase II second largest subunit B150 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| MGE1 |
YOR232W |
Mitochondrial matrix cochaperone |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RRS1 |
YOR294W |
Essential protein that binds ribosomal protein L11 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RPA43 |
YOR340C |
RNA polymerase I subunit A43 |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RVB2 |
YPL235W |
ATP-dependent DNA helicase, also known as reptin |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| TIF6 |
YPR016C |
Constituent of 66S pre-ribosomal particles |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| RRP15 |
YPR143W |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| NUT2 |
YPR168W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SMC5 |
YOL034W |
Subunit of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SMX3 |
YPR182W |
Core Sm protein Sm F |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRPL27 |
YBR282W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| REB1 |
YBR049C |
RNA polymerase I enhancer binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCM3 |
YDL139C |
Nonhistone component of centromeric chromatin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBC1 |
YDR177W |
Ubiquitin-conjugating enzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YRA1 |
YDR381W |
Nuclear polyadenylated RNA-binding protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NTF2 |
YER009W |
Nuclear envelope protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPE1 |
YKL059C |
Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PDS5 |
YMR076C |
Cohesion maintenance factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| POL2 |
YNL262W |
Catalytic subunit of DNA polymerase (II) epsilon |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ULP1 |
YPL020C |
Protease that specifically cleaves Smt3p protein conjugates |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC29 |
YPL124W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MEX67 |
YPL169C |
Poly(A)RNA binding protein involved in nuclear mRNA export |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRP1 |
YDR087C |
Essential evolutionarily conserved nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCC4 |
YER147C |
Subunit of cohesin loading factor (Scc2p-Scc4p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MOB2 |
YFL034C-B |
Activator of Cbk1p kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC97 |
YHR172W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRI1 |
YDL216C |
Catalytic subunit of the COP9 signalosome (CSN) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRP4 |
YDR354W |
Anthranilate phosphoribosyl transferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGR1 |
YCL044C |
Subunit of the mitochondrial (mt) i-AAA protease supercomplex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA21 |
YGR105W |
Integral membrane protein required for V-ATPase function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YGR117C |
YGR117C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NDE1 |
YMR145C |
Mitochondrial external NADH dehydrogenase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PAN6 |
YIL145C |
Pantothenate synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SET1 |
YHR119W |
Histone methyltransferase, subunit of the COMPASS (Set1C) complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PSH1 |
YOL054W |
E3 ubiquitin ligase targeting centromere-binding protein Cse4p |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| UBR2 |
YLR024C |
Cytoplasmic ubiquitin-protein ligase (E3) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SUR7 |
YML052W |
Plasma membrane protein, component of eisosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR072W-B |
YOR072W-B |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RTT107 |
YHR154W |
BRCA1 C-terminal domain protein needed for recovery from DNA damage |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SHO1 |
YER118C |
Transmembrane osmosensor for filamentous growth and HOG pathways |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSA1 |
YML028W |
Thioredoxin peroxidase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PIN4 |
YBL051C |
Protein involved in G2/M phase progression and response to DNA damage |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MXR2 |
YCL033C |
Methionine-R-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| THR4 |
YCR053W |
Threonine synthase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| QRI1 |
YDL103C |
UDP-N-acetylglucosamine pyrophosphorylase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TRS85 |
YDR108W |
Component of transport protein particle (TRAPP) complex III |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SWF1 |
YDR126W |
Palmitoyltransferase that acts on transmembrane proteins |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLY1 |
YDR189W |
Hydrophilic protein involved in ER/Golgi vesicle trafficking |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SUM1 |
YDR310C |
Transcriptional repressor that regulates middle-sporulation genes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| UTP6 |
YDR449C |
Nucleolar protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS24A |
YER074W |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PET122 |
YER153C |
Mitochondrial translational activator specific for the COX3 mRNA |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YOR1 |
YGR281W |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STB5 |
YHR178W |
Transcription factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAV1 |
YJR033C |
Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YKL069W |
YKL069W |
Methionine-R-sulfoxide reductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NSE5 |
YML023C |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RUD3 |
YOR216C |
Golgi matrix protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YPL071C |
YPL071C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MGR2 |
YPL098C |
Subunit of the TIM23 translocase complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAR1 |
YPL239W |
Nucleocytoplasmic shuttling assembly chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED1 |
YPR070W |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTP3 |
YER075C |
Phosphotyrosine-specific protein phosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MAD3 |
YJL013C |
Subunit of spindle-assembly checkpoint complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| VAC17 |
YCL063W |
Phosphoprotein involved in vacuole inheritance |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SLP1 |
YOR154W |
Glycosylated integral ER membrane protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STE6 |
YKL209C |
Plasma membrane ATP-binding cassette (ABC) transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NIS1 |
YNL078W |
Protein involved in axial bud site selection |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SWE1 |
YJL187C |
Protein kinase that regulates the G2/M transition |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| BIK1 |
YCL029C |
Microtubule-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CBF2 |
YGR140W |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| CCZ1 |
YBR131W |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BBP1 |
YPL255W |
Protein required for the spindle pole body (SPB) duplication |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HSF1 |
YGL073W |
Trimeric heat shock transcription factor |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KAR2 |
YJL034W |
ATPase involved in protein import into the ER |
physical |
1 |
1 |
1 |
Two-hybrid |
| FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
physical |
1 |
1 |
1 |
Two-hybrid |
| GTS1 |
YGL181W |
Protein involved in Arf3p regulation and in transcription regulation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| HBS1 |
YKR084C |
GTPase with similarity to translation release factors |
genetic |
1 |
1 |
1 |
Negative Genetic |
| COY1 |
YKL179C |
Golgi membrane protein with similarity to mammalian CASP |
physical |
1 |
1 |
1 |
Two-hybrid |
| ERG2 |
YMR202W |
C-8 sterol isomerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ATP15 |
YPL271W |
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ASE1 |
YOR058C |
Mitotic spindle midzone-localized microtubule bundling protein |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DSE4 |
YNR067C |
Daughter cell-specific secreted protein with similarity to glucanases |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BRL1 |
YHR036W |
Essential nuclear envelope/ER integral membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRC3 |
YDR332W |
Double-stranded DNA-dependent helicase of the DExH/D-box family |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| GCD14 |
YJL125C |
Subunit of tRNA (1-methyladenosine) methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| KAE1 |
YKR038C |
Highly conserved ATPase of HSP70/DnaK family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIP5 |
YOR196C |
Protein involved in biosynthesis of the coenzyme lipoic acid |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IRC25 |
YLR021W |
Component of a heterodimeric Poc4p-Irc25p chaperone |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALT1 |
YLR089C |
Alanine transaminase (glutamic pyruvic transaminase) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI17 |
YDR434W |
Transmembrane protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| CHS6 |
YJL099W |
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BST1 |
YFL025C |
GPI inositol deacylase of the endoplasmic reticulum (ER) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI12 |
YMR281W |
ER membrane protein involved in the second step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| EOS1 |
YNL080C |
Protein involved in N-glycosylation |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| LIP1 |
YMR298W |
Ceramide synthase subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| ERG3 |
YLR056W |
C-5 sterol desaturase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| FRT1 |
YOR324C |
Tail-anchored ER membrane protein of unknown function |
physical |
1 |
1 |
1 |
Two-hybrid |
| ALG2 |
YGL065C |
Mannosyltransferase in the N-linked glycosylation pathway |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AVT5 |
YBL089W |
Putative transporter |
genetic |
1 |
1 |
1 |
Positive Genetic |
| LAM4 |
YHR080C |
Sterol-binding protein that localizes to puncta in the cortical ER |
physical |
1 |
1 |
1 |
Two-hybrid |
| CAB2 |
YIL083C |
Phosphopantothenoylcysteine synthetase (PPCS) |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| AAT1 |
YKL106W |
Mitochondrial aspartate aminotransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KRE5 |
YOR336W |
Protein required for beta-1,6 glucan biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
