Standard name Systematic name Name description Description
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase Cytosolic copper-zinc superoxide dismutase; detoxifies superoxide; stabilizes Yck1p and Yck2p kinases in glucose to repress respiration; phosphorylated by Dun1p, enters nucleus under oxidative stress to promote transcription of stress response genes; human ortholog SOD1 implicated in ALS complements a null allele; abundance increases under DNA replication stress and during exposure to boric acid; localization to mitochondrial intermembrane space is modulated by MICOS complex
Visualize the interactome of SOD1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 1.0 0.938 0.992
Mito NaN 0.062 NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous, cytoplasm, nucleus 519000

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SOD1 4 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8
r_4270 (superoxide:superoxide oxidoreductase)

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 10 4 9 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 8 2 8 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p physical 8 5 7 Reconstituted Complex, Two-hybrid, Two-hybrid, Co-crystal Structure, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 6 2 6 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality
TKL1 YPR074C Transketolase genetic 5 2 3 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 4 1 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
GIS1 YDR096W Histone demethylase and transcription factor genetic 4 3 2 Phenotypic Suppression, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression
RAD51 YER095W Strand exchange protein genetic 3 3 3 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 3 3 3 Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 3 3 2 Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
SCO2 YBR024W Protein anchored to mitochondrial inner membrane genetic 3 2 2 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 3 3 1 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement
BRE1 YDL074C E3 ubiquitin ligase genetic 2 2 2 Negative Genetic, Synthetic Lethality
BDF1 YLR399C BET family transcriptional regulator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
ECM5 YMR176W Subunit of the Snt2C complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 2 2 Negative Genetic, Synthetic Lethality
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SUB1 YMR039C Transcriptional regulator genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 2 2 2 Positive Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD24 YER173W Checkpoint protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 2 2 2 Negative Genetic, Synthetic Lethality
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 2 2 2 Affinity Capture-MS, PCA
MSN2 YMR037C Stress-responsive transcriptional activator genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
PHO80 YOL001W Cyclin genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 2 2 Negative Genetic, Synthetic Lethality
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Negative Genetic, Synthetic Lethality
BYE1 YKL005C Negative regulator of transcription elongation genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
MSN4 YKL062W Stress-responsive transcriptional activator genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
SCH9 YHR205W AGC family protein kinase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 2 2 Negative Genetic, Synthetic Lethality
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 2 2 Negative Genetic, Synthetic Lethality
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
IRA2 YOL081W GTPase-activating protein genetic 2 1 2 Negative Genetic, Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 2 1 2 Negative Genetic, Negative Genetic
SSQ1 YLR369W Mitochondrial hsp70-type molecular chaperone genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Negative Genetic, Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
JAC1 YGL018C Specialized J-protein that functions in Fe-S cluster biogenesis genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
SMF1 YOL122C Divalent metal ion transporter genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MCM2 YBL023C Protein involved in DNA replication genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 DNA to cDNA expression microarray evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 DNA to cDNA expression microarray evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN4 YKL062W Stress-responsive transcriptional activator regulation 1 1 1 RNA-sequencing evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT6 YGR116W Nucleosome remodeling protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
INO2 YDR123C Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HAP1 YLR256W Zinc finger transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
INO4 YOL108C Transcription factor involved in phospholipid synthesis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Negative Genetic
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space physical 1 1 1 Co-purification
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Phenotypic Enhancement
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Lethality
BNI1 YNL271C Formin physical 1 1 1 Reconstituted Complex
BNI1 YNL271C Formin genetic 1 1 1 Positive Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Synthetic Lethality
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Phenotypic Suppression
HHF1 YBR009C Histone H4 genetic 1 1 1 Phenotypic Suppression
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
MBP1 YDL056W Transcription factor genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 PCA
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor physical 1 1 1 Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 1 1 1 Synthetic Growth Defect
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
SAM1 YLR180W S-adenosylmethionine synthetase genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Positive Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors physical 1 1 1 Affinity Capture-MS
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 1 1 1 Synthetic Rescue
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Dosage Rescue
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Synthetic Growth Defect
ACO1 YLR304C Aconitase genetic 1 1 1 Phenotypic Suppression
PHO84 YML123C High-affinity inorganic phosphate (Pi) transporter genetic 1 1 1 Synthetic Lethality
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase genetic 1 1 1 Phenotypic Enhancement
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Synthetic Rescue
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Phenotypic Enhancement
YJU2 YKL095W Essential protein required for pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 1 1 1 Co-crystal Structure
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 1 1 1 PCA
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 1 1 1 PCA
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter genetic 1 1 1 Synthetic Rescue
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
YFH1 YDL120W Mitochondrial matrix iron chaperone physical 1 1 1 Reconstituted Complex
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-RNA
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Phenotypic Suppression
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Phenotypic Suppression
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 1 1 1 Negative Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase genetic 1 1 1 Synthetic Lethality
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase genetic 1 1 1 Synthetic Growth Defect
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Phenotypic Enhancement
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Lethality
STB4 YMR019W Putative transcription factor genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
THI2 YBR240C Transcriptional activator of thiamine biosynthetic genes genetic 1 1 1 Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Lethality
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Positive Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Positive Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
TRX3 YCR083W Mitochondrial thioredoxin genetic 1 1 1 Synthetic Growth Defect
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Synthetic Lethality
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Lethality
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Synthetic Lethality
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Lethality
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 1 1 1 Phenotypic Enhancement
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Synthetic Lethality
SEN15 YMR059W Subunit of the tRNA splicing endonuclease physical 1 1 1 Affinity Capture-MS
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Synthetic Rescue
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Suppression
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Phenotypic Enhancement
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Phenotypic Enhancement
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 1 1 1 Synthetic Growth Defect
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Phenotypic Enhancement
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Synthetic Lethality
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Synthetic Rescue
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Lethality
IME4 YGL192W mRNA N6-adenosine methyltransferase genetic 1 1 1 Positive Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Positive Genetic
HAA1 YPR008W Transcriptional activator involved in adaptation to weak acid stress genetic 1 1 1 Phenotypic Enhancement
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Positive Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Synthetic Lethality
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Phenotypic Enhancement
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Synthetic Lethality
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Phenotypic Suppression
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Synthetic Lethality
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Synthetic Lethality
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
KAR2 YJL034W ATPase involved in protein import into the ER physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CCP1 YKR066C Mitochondrial cytochrome-c peroxidase physical 1 1 1 Affinity Capture-MS
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Growth Defect
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Synthetic Rescue
COQ1 YBR003W Hexaprenyl pyrophosphate synthetase genetic 1 1 1 Synthetic Rescue
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Phenotypic Enhancement
ARK1 YNL020C Ser/Thr protein kinase physical 1 1 1 Biochemical Activity
GSM1 YJL103C Putative zinc cluster protein of unknown function genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
PXA2 YKL188C Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p physical 1 1 1 PCA
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 1 1 1 Synthetic Growth Defect
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Synthetic Growth Defect
DDR48 YMR173W DNA damage-responsive protein genetic 1 1 1 Negative Genetic
IPF1 YDL176W Protein of unknown function involved in actin patch formation physical 1 1 1 Affinity Capture-MS
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Negative Genetic
RDS2 YPL133C Transcription factor involved in regulating gluconeogenesis genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
CLB4 YLR210W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Synthetic Growth Defect
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
ECM22 YLR228C Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
SGO1 YOR073W Component of the spindle checkpoint genetic 1 1 1 Negative Genetic
HEM2 YGL040C Aminolevulinate dehydratase genetic 1 1 1 Synthetic Growth Defect
ALG7 YBR243C UDP-N-acetyl-glucosamine-1-P transferase genetic 1 1 1 Dosage Rescue
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Phenotypic Suppression
RDS1 YCR106W Putative zinc cluster transcription factor genetic 1 1 1 Positive Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
ATX2 YOR079C Golgi membrane protein involved in manganese homeostasis genetic 1 1 1 Dosage Rescue
SMF2 YHR050W Divalent metal ion transporter involved in manganese homeostasis genetic 1 1 1 Phenotypic Enhancement
CUP1-1 YHR053C Metallothionein genetic 1 1 1 Dosage Rescue
MMT1 YMR177W Putative metal transporter involved in mitochondrial iron accumulation genetic 1 1 1 Dosage Rescue