Standard name Systematic name Name description Description
PAP2 YOL115W Non-canonical poly(A) polymerase Non-canonical poly(A) polymerase; involved in nuclear RNA degradation as a component of TRAMP; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; required for mRNA surveillance and maintenance of genome integrity, serving as a link between RNA and DNA metabolism; overlapping but non-redundant functions with Trf5p; relocalizes to cytosol in response to hypoxia
Visualize the interactome of PAP2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.124 NaN NaN
Nucleus 0.941 0.956 NaN

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
PAP2 48 1 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
AIR2 YDL175C RNA-binding subunit of the TRAMP nuclear RNA surveillance complex physical 19 5 14 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Co-crystal Structure, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
MTR4 YJL050W RNA duplex-sensing translocase physical 19 6 12 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, PCA, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Affinity Capture-MS
TRF5 YNL299W Non-canonical poly(A) polymerase genetic 13 4 10 Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 13 6 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Protein-peptide, Co-crystal Structure, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
AIR1 YIL079C Zinc knuckle protein physical 11 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component genetic 7 4 6 Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
TOP1 YOL006C Topoisomerase I genetic 6 3 6 Phenotypic Enhancement, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 4 4 3 Synthetic Lethality, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 4 3 3 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
AIR2 YDL175C RNA-binding subunit of the TRAMP nuclear RNA surveillance complex genetic 3 2 3 Negative Genetic, Negative Genetic, Dosage Rescue
HTZ1 YOL012C Histone variant H2AZ genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
PRP43 YGL120C RNA helicase in the DEAH-box family physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
HIR1 YBL008W Subunit of the HIR complex genetic 3 3 2 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
TRF5 YNL299W Non-canonical poly(A) polymerase physical 3 2 2 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
TRM8 YDL201W Catalytic subunit of a tRNA methyltransferase complex genetic 3 2 2 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
NPL3 YDR432W RNA-binding protein genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
HPR1 YDR138W Subunit of THO/TREX complexes genetic 2 2 2 Synthetic Lethality, Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Reconstituted Complex
ASF1 YJL115W Nucleosome assembly factor genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 2 2 2 Negative Genetic, Synthetic Lethality
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PAP1 YKR002W Poly(A) polymerase genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
NOP53 YPL146C Nucleolar protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
TRM9 YML014W tRNA methyltransferase genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
AIR1 YIL079C Zinc knuckle protein genetic 2 2 2 Positive Genetic, Dosage Rescue
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 2 2 Synthetic Lethality, Negative Genetic
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MPP6 YNR024W Nuclear exosome-associated RNA binding protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Positive Genetic, Positive Genetic
HSP82 YPL240C Hsp90 chaperone genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 2 1 2 Positive Genetic, Positive Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Positive Genetic, Positive Genetic
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 2 1 2 Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPS18B YML026C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MSL1 YIR009W U2B component of U2 snRNP genetic 2 2 1 Phenotypic Enhancement, Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 2 2 1 Affinity Capture-Western, Two-hybrid
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Positive Genetic
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Enhancement
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
BRX1 YOL077C Nucleolar protein genetic 1 1 1 Negative Genetic
NUC1 YJL208C Major mitochondrial nuclease genetic 1 1 1 Negative Genetic
NOC2 YOR206W Protein involved in ribosome biogenesis physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Negative Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 Affinity Capture-MS
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins physical 1 1 1 Affinity Capture-MS
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Synthetic Lethality
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 Affinity Capture-MS
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 1 1 1 Affinity Capture-MS
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Affinity Capture-MS
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
APL3 YBL037W Alpha-adaptin genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Lethality
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 1 1 1 Affinity Capture-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-Western
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
DPB2 YPR175W Second largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Dosage Rescue
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
BDF2 YDL070W Protein involved in transcription initiation genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 genetic 1 1 1 Synthetic Rescue
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Phenotypic Enhancement
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Synthetic Lethality
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Phenotypic Suppression
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Negative Genetic
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Positive Genetic
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Synthetic Rescue
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Positive Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Lethality
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Negative Genetic
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex physical 1 1 1 Affinity Capture-Western
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Dosage Rescue
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
MIR1 YJR077C Mitochondrial phosphate carrier genetic 1 1 1 Negative Genetic
CSN9 YDR179C Subunit of the Cop9 signalosome genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
KTR3 YBR205W Putative alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Positive Genetic
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Lethality
DAL3 YIR032C Ureidoglycolate lyase genetic 1 1 1 Positive Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Growth Defect
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 1 1 1 Positive Genetic
NGL2 YMR285C Protein involved in 5.8S rRNA processing genetic 1 1 1 Positive Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Synthetic Lethality
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Negative Genetic
CNB1 YKL190W Calcineurin B genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Positive Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Negative Genetic
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Synthetic Growth Defect
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Positive Genetic
MCX1 YBR227C Non-proteolytic ATPase of the AAA family genetic 1 1 1 Negative Genetic
ARE1 YCR048W Acyl-CoA:sterol acyltransferase genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Growth Defect
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Enhancement
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 1 1 1 Affinity Capture-MS
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 1 1 1 Affinity Capture-MS
SMC2 YFR031C Subunit of the condensin complex physical 1 1 1 Affinity Capture-MS
RRP43 YCR035C Exosome non-catalytic core component physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Reconstituted Complex
SKI6 YGR195W Exosome non-catalytic core component physical 1 1 1 Affinity Capture-Western
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
PRP42 YDR235W U1 snRNP protein involved in splicing physical 1 1 1 Affinity Capture-Western
PRP16 YKR086W DEAH-box RNA helicase physical 1 1 1 Affinity Capture-Western
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Affinity Capture-MS
PUB1 YNL016W Poly (A)+ RNA-binding protein physical 1 1 1 Affinity Capture-MS
THO2 YNL139C Subunit of the THO complex physical 1 1 1 Affinity Capture-MS
SNU13 YEL026W RNA binding protein physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Dosage Rescue
ZDS2 YML109W Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Dosage Rescue
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Lethality
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Phenotypic Enhancement
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Synthetic Rescue
TRM44 YPL030W tRNA(Ser) Um(44) 2'-O-methyltransferase genetic 1 1 1 Synthetic Rescue
TAN1 YGL232W Putative tRNA acetyltransferase genetic 1 1 1 Synthetic Rescue
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Negative Genetic
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Negative Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Negative Genetic
REX4 YOL080C Putative RNA exonuclease genetic 1 1 1 Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PUS1 YPL212C tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 1 1 1 Positive Genetic
TIF35 YDR429C eIF3g subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Synthetic Growth Defect
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Phenotypic Enhancement
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
UIP3 YAR027W Putative integral membrane protein of unknown function genetic 1 1 1 Negative Genetic
SEA4 YBL104C Subunit of SEACAT, a subcomplex of the SEA complex genetic 1 1 1 Negative Genetic
SEF1 YBL066C Putative transcription factor genetic 1 1 1 Positive Genetic
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 genetic 1 1 1 Positive Genetic
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Negative Genetic
YPK3 YBR028C AGC kinase genetic 1 1 1 Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A genetic 1 1 1 Positive Genetic
ZTA1 YBR046C NADPH-dependent quinone reductase genetic 1 1 1 Negative Genetic
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
YBR220C YBR220C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PBP2 YBR233W RNA binding protein genetic 1 1 1 Negative Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
TAE1 YBR261C AdoMet-dependent proline methyltransferase genetic 1 1 1 Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Negative Genetic
PPS1 YBR276C Protein phosphatase genetic 1 1 1 Negative Genetic
PCA1 YBR295W Cadmium transporting P-type ATPase genetic 1 1 1 Positive Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 1 1 1 Positive Genetic
PEX34 YCL056C Protein that regulates peroxisome populations genetic 1 1 1 Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
YCR007C YCR007C Putative integral membrane protein genetic 1 1 1 Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 1 1 1 Negative Genetic
SYP1 YCR030C Negative regulator of WASP-Arp23 complex genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
YCR043C YCR043C Putative protein of unknown function genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Negative Genetic
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Positive Genetic
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
SOL2 YCR073W-A Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
TRX3 YCR083W Mitochondrial thioredoxin genetic 1 1 1 Negative Genetic
YCR090C YCR090C Putative protein of unknown function genetic 1 1 1 Negative Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
RPL41B YDL133C-A Ribosomal 60S subunit protein L41B genetic 1 1 1 Negative Genetic
SRF1 YDL133W Regulator of phospholipase D (Spo14p) genetic 1 1 1 Negative Genetic
YDL129W YDL129W Protein of unknown function genetic 1 1 1 Negative Genetic
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis genetic 1 1 1 Positive Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
THI3 YDL080C Regulatory protein that binds Pdc2p and Thi2p transcription factors genetic 1 1 1 Positive Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Positive Genetic
PRM7 YDL039C Pheromone-regulated protein genetic 1 1 1 Positive Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
SOK1 YDR006C Protein of unknown function genetic 1 1 1 Negative Genetic
PHM6 YDR281C Protein of unknown function genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 1 1 1 Negative Genetic
PIB1 YDR313C RING-type ubiquitin ligase of the endosomal and vacuolar membranes genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Negative Genetic
SDL1 YIL167W Blocked reading frame otherwise encoding L-serine dehydratase genetic 1 1 1 Negative Genetic
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Positive Genetic
POG1 YIL122W DNA-binding transcriptional activator genetic 1 1 1 Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RCI37 YIL077C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Negative Genetic
VLD1 YIR014W Component of Dsc E3 ligase complex in vacuolar membranes genetic 1 1 1 Negative Genetic
YJL206C YJL206C Putative protein of unknown function genetic 1 1 1 Positive Genetic
PHO90 YJL198W Low-affinity phosphate transporter genetic 1 1 1 Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Positive Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
XPT1 YJR133W Xanthine-guanine phosphoribosyl transferase genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
TRP3 YKL211C Indole-3-glycerol-phosphate synthase genetic 1 1 1 Negative Genetic
SFK1 YKL051W Protein that regulates phospholipid asymmetry at plasma membrane genetic 1 1 1 Negative Genetic
PTM1 YKL039W Protein of unknown function genetic 1 1 1 Positive Genetic
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Negative Genetic
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 1 1 1 Negative Genetic
UTP30 YKR060W Subunit of U3-containing 90S preribosome complex genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Positive Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Positive Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Negative Genetic
YPT7 YML001W Rab family GTPase genetic 1 1 1 Negative Genetic
PLB2 YMR006C Phospholipase B (lysophospholipase) involved in lipid metabolism genetic 1 1 1 Negative Genetic
PEX9 YMR018W Peroxisomal membrane signal receptor for peroxisomal matrix proteins genetic 1 1 1 Negative Genetic
SIP18 YMR175W Phospholipid-binding hydrophilin genetic 1 1 1 Positive Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 1 1 1 Positive Genetic
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase genetic 1 1 1 Negative Genetic
RCE1 YMR274C Type II CAAX prenyl protease genetic 1 1 1 Negative Genetic
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 1 1 1 Positive Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
YPK9 YOR291W Vacuolar protein with a possible role in sequestering heavy metals genetic 1 1 1 Negative Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Positive Genetic
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
PIP2 YOR363C Autoregulatory, oleate-activated transcription factor genetic 1 1 1 Positive Genetic
SET6 YPL165C SET domain protein of unknown function genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Positive Genetic
YPL068C YPL068C Protein of unknown function genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
PUF2 YPR042C PUF family mRNA-binding protein genetic 1 1 1 Negative Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Positive Genetic
YPR096C YPR096C Protein of unknown function genetic 1 1 1 Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
PEX13 YLR191W Peroxisomal importomer complex component genetic 1 1 1 Synthetic Growth Defect
PEX2 YJL210W RING-finger peroxin and E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Synthetic Growth Defect
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Synthetic Growth Defect
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Growth Defect
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Synthetic Lethality
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Synthetic Growth Defect
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Synthetic Growth Defect
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Synthetic Lethality
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Synthetic Lethality
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Lethality
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Synthetic Lethality
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Synthetic Lethality
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Synthetic Lethality
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Synthetic Lethality
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Rescue
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Positive Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Positive Genetic
REX2 YLR059C 3'-5' RNA exonuclease genetic 1 1 1 Negative Genetic
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Negative Genetic
SRP14 YDL092W Signal recognition particle (SRP) subunit genetic 1 1 1 Phenotypic Suppression
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Phenotypic Suppression
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Positive Genetic
GDT1 YBR187W Calcium and manganese transporter with higher affinity for Ca2+ genetic 1 1 1 Positive Genetic
LOS1 YKL205W Nuclear pore protein genetic 1 1 1 Negative Genetic
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
GBP2 YCL011C Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-MS
GBP2 YCL011C Poly(A+) RNA-binding protein genetic 1 1 1 Positive Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Growth Defect
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Lethality
ARA1 YBR149W NADP+ dependent arabinose dehydrogenase genetic 1 1 1 Positive Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Synthetic Lethality
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Growth Defect
ECM31 YBR176W Ketopantoate hydroxymethyltransferase genetic 1 1 1 Negative Genetic
FIG1 YBR040W Integral membrane protein required for efficient mating genetic 1 1 1 Positive Genetic
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Negative Genetic
JSN1 YJR091C Member of the Puf family of RNA-binding proteins genetic 1 1 1 Positive Genetic
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 1 1 1 Negative Genetic
DLS1 YJL065C Subunit of ISW2/yCHRAC chromatin accessibility complex genetic 1 1 1 Negative Genetic
LDB17 YDL146W Protein involved in the regulation of endocytosis genetic 1 1 1 Negative Genetic
ESL1 YIL151C hEST1A/B (SMG5/6)-like protein genetic 1 1 1 Synthetic Lethality
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Positive Genetic
BLI1 YKL061W Subunit of the BLOC-1 complex involved in endosomal maturation genetic 1 1 1 Negative Genetic
FMP40 YPL222W Mitochondrial AMPylator in the pseudokinase selenoprotein-O family genetic 1 1 1 Negative Genetic
CUB1 YPL260W Conserved fungal gene linked to DNA repair and proteasome function genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Rescue
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
IES6 YEL044W Component of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Growth Defect
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Synthetic Lethality
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Positive Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 1 1 1 Positive Genetic
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Positive Genetic
FBP26 YJL155C Fructose-2,6-bisphosphatase, required for glucose metabolism genetic 1 1 1 Negative Genetic
ATC1 YDR184C Nuclear protein genetic 1 1 1 Positive Genetic
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Negative Genetic
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Rescue
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Lethality
MSL5 YLR116W Component of commitment complex physical 1 1 1 Affinity Capture-Western
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 1 1 1 Dosage Rescue
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Negative Genetic
MMT2 YPL224C Putative metal transporter involved in mitochondrial iron accumulation genetic 1 1 1 Negative Genetic
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase genetic 1 1 1 Positive Genetic
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Negative Genetic
DUS3 YLR401C Dihydrouridine synthase genetic 1 1 1 Synthetic Rescue
HUL4 YJR036C Protein with similarity to hect domain E3 ubiquitin-protein ligases physical 1 1 1 Affinity Capture-MS
EHT1 YBR177C Octanoyl-CoA:ethanol acyltransferase genetic 1 1 1 Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MPP6 YNR024W Nuclear exosome-associated RNA binding protein physical 1 1 1 Affinity Capture-MS
FUN14 YAL008W Integral mitochondrial outer membrane (MOM) protein genetic 1 1 1 Positive Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Positive Genetic
NDE2 YDL085W Mitochondrial external NADH dehydrogenase genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Positive Genetic
INM2 YDR287W Inositol monophosphatase genetic 1 1 1 Negative Genetic
DNF1 YER166W Aminophospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Negative Genetic
AHC2 YCR082W Component of the ADA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 1 1 1 Phenotypic Enhancement
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Negative Genetic
MGR3 YMR115W Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Positive Genetic
MRX9 YDL027C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
MRX3 YBL095W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
OSW1 YOR255W Protein involved in sporulation genetic 1 1 1 Negative Genetic
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Phenotypic Enhancement
ITR1 YDR497C Myo-inositol transporter genetic 1 1 1 Synthetic Growth Defect
FRM2 YCL026C-A Type II nitroreductase, using NADH as reductant genetic 1 1 1 Positive Genetic
CPR4 YCR069W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
ERS1 YCR075C Protein involved in cystine transport genetic 1 1 1 Negative Genetic
HLJ1 YMR161W Co-chaperone for Hsp40p genetic 1 1 1 Negative Genetic
MAK31 YCR020C-A Non-catalytic subunit of N-terminal acetyltransferase of the NatC type genetic 1 1 1 Positive Genetic
ATG15 YCR068W Phospholipase genetic 1 1 1 Negative Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Positive Genetic
KHA1 YJL094C Putative K+/H+ antiporter genetic 1 1 1 Positive Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Positive Genetic
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 1 1 1 Positive Genetic
MXR2 YCL033C Methionine-R-sulfoxide reductase genetic 1 1 1 Positive Genetic
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog genetic 1 1 1 Positive Genetic
GRX6 YDL010W Cis-Golgi localized monothiol glutaredoxin, binds Fe-S cluster genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Synthetic Lethality
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
MAK32 YCR019W Protein necessary for stability of L-A dsRNA-containing particles genetic 1 1 1 Positive Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Positive Genetic
DIA3 YDL024C Protein of unknown function genetic 1 1 1 Negative Genetic
AGP1 YCL025C Broad-specificity, low-affinity amino acid permease genetic 1 1 1 Positive Genetic
GIT1 YCR098C Plasma membrane permease genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Positive Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
NCE101 YJL205C Protein of unknown function genetic 1 1 1 Positive Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Positive Genetic
NPP1 YCR026C Nucleotide pyrophosphatase/phosphodiesterase genetic 1 1 1 Positive Genetic
NCA3 YJL116C Protein involved in mitochondrion organization genetic 1 1 1 Negative Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Positive Genetic