Standard name Systematic name Name description Description
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p; protein abundance increases in response to DNA replication stress
Visualize the interactome of RPN12
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleolus 0.111 0.096 NaN
Nucleus 0.810 0.756 0.70
Vac/Vac Memb NaN 0.185 0.25
Cytoplasm NaN NaN 0.05

GFP localization & abundance

GFP localization GFP abundance
nucleus 9890

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RPN12 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 29 5 23 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Co-purification, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Reconstituted Complex, Co-purification, Reconstituted Complex
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 10 4 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 9 4 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Co-purification, PCA
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 9 3 8 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 9 4 7 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 9 4 7 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPN10 YHR200W Proteasome polyubiquitin receptor physical 9 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 8 2 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 7 5 6 Synthetic Lethality, Dosage Rescue, Negative Genetic, Positive Genetic, Positive Genetic, Synthetic Growth Defect, Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 7 3 6 Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 6 3 6 Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 6 3 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 4 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 4 3 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence
CDC73 YLR418C Component of the Paf1p complex genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 3 2 3 Synthetic Lethality, Dosage Rescue, Dosage Rescue
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 3 2 3 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 3 2 2 Positive Genetic, Positive Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM29 YHL030W Scaffold protein physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RAD51 YER095W Strand exchange protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DDI1 YER143W Aspartic-type endopeptidase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation physical 3 2 1 Co-fractionation, Affinity Capture-Western, Affinity Capture-Western
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 2 2 2 Negative Genetic, Dosage Rescue
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Dosage Lethality, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Synthetic Lethality, Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Negative Genetic, Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 2 1 2 Negative Genetic, Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 2 Negative Genetic, Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 2 1 2 Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
RPN2 YIL075C Subunit of the 26S proteasome genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 2 1 2 Negative Genetic, Negative Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 2 1 2 Negative Genetic, Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 2 1 2 Negative Genetic, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 2 1 2 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 2 1 2 Negative Genetic, Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 2 1 2 Negative Genetic, Negative Genetic
YOX1 YML027W Homeobox transcriptional repressor genetic 2 1 2 Negative Genetic, Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 2 1 2 Negative Genetic, Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 2 1 2 Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 2 Negative Genetic, Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 2 1 2 Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 2 Negative Genetic, Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Positive Genetic, Positive Genetic
MBP1 YDL056W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
FDO1 YMR144W Protein involved in directionality of mating type switching genetic 2 1 2 Negative Genetic, Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 2 1 2 Negative Genetic, Negative Genetic
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 2 Negative Genetic, Negative Genetic
MSN5 YDR335W Karyopherin genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing genetic 2 1 2 Negative Genetic, Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 1 2 Negative Genetic, Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 1 2 Negative Genetic, Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 2 1 2 Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Positive Genetic, Positive Genetic
MAK31 YCR020C-A Non-catalytic subunit of N-terminal acetyltransferase of the NatC type genetic 2 1 2 Negative Genetic, Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 2 1 Negative Genetic, Positive Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 1 Synthetic Growth Defect, Dosage Growth Defect
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 2 1 1 Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 1 Negative Genetic, Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 2 1 1 Negative Genetic, Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 1 Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 1 1 Negative Genetic, Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 2 1 1 Negative Genetic, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 2 1 1 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
TIM50 YPL063W Essential component of the TIM23 complex genetic 2 1 1 Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 1 Negative Genetic, Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 2 1 1 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 1 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 1 1 Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 1 Negative Genetic, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 1 1 Negative Genetic, Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 1 Negative Genetic, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 2 1 1 Negative Genetic, Negative Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 2 1 1 Negative Genetic, Negative Genetic
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 2 1 1 Negative Genetic, Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 1 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 1 Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 2 1 1 Negative Genetic, Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 2 1 1 Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 1 1 Negative Genetic, Negative Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 2 1 1 Negative Genetic, Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 2 1 1 Negative Genetic, Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 2 1 1 Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC40 YDR364C Pre-mRNA splicing factor genetic 1 1 1 Negative Genetic
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Negative Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
POP5 YAL033W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
POL5 YEL055C Protein involved in 60S assembly and pre-40S AFs recycling genetic 1 1 1 Negative Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 1 1 1 Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 1 1 1 Positive Genetic
RPC17 YJL011C RNA polymerase III subunit C17 genetic 1 1 1 Negative Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Co-fractionation
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase physical 1 1 1 Affinity Capture-MS
PRP40 YKL012W U1 snRNP protein involved in splicing genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-MS
XPT1 YJR133W Xanthine-guanine phosphoribosyl transferase physical 1 1 1 Two-hybrid
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
VPS45 YGL095C Protein of the Sec1p/Munc-18 family physical 1 1 1 Affinity Capture-MS
TOR2 YKL203C PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-MS
YTA12 YMR089C Mitochondrial inner membrane m-AAA protease component physical 1 1 1 Affinity Capture-MS
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
STS1 YIR011C Protein required for localizing proteasomes to the nucleus physical 1 1 1 Affinity Capture-Western
UFO1 YML088W F-box receptor protein physical 1 1 1 Affinity Capture-Western
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-Western
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation genetic 1 1 1 Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SHE1 YBL031W Mitotic spindle protein genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Synthetic Lethality
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 1 1 1 Negative Genetic
SND3 YBR106W Involved in SRP-independent protein targeting to the ER genetic 1 1 1 Positive Genetic
TIR2 YOR010C Putative cell wall mannoprotein genetic 1 1 1 Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Positive Genetic
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Positive Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
TRM2 YKR056W tRNA methyltransferase genetic 1 1 1 Positive Genetic
YLR154C-H YLR154C-H Putative protein of unknown function genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Negative Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
SNU13 YEL026W RNA binding protein genetic 1 1 1 Negative Genetic
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Negative Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Negative Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
THI80 YOR143C Thiamine pyrophosphokinase genetic 1 1 1 Negative Genetic
TFC8 YPL007C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
UBS1 YBR165W Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
RPS23B YPR132W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Negative Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 1 1 1 Negative Genetic
YHR213W-B YHR213W-B Pseudogenic fragment with similarity to flocculins genetic 1 1 1 Negative Genetic
VHS2 YIL135C Regulator of septin dynamics genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
SHB17 YKR043C Sedoheptulose bisphosphatase involved in riboneogenesis genetic 1 1 1 Negative Genetic
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Negative Genetic
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YMR001C-A YMR001C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSF1 YMR030W Protein required for respiratory growth genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
SNF12 YNR023W 73 kDa subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
YOL163W YOL163W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR072W-B YOR072W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall genetic 1 1 1 Negative Genetic
SNX3 YOR357C Sorting nexin for late-Golgi enzymes genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Negative Genetic
YPL264C YPL264C Endoplasmic reticulum protein of unknown function genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Synthetic Growth Defect
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Synthetic Growth Defect
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Positive Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Negative Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
KRE33 YNL132W Acetyltransferase required for biogenesis of small ribosomal subunit genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Positive Genetic
ATG3 YNR007C E2-like enzyme genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
MRPL38 YKL170W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Positive Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
NOP14 YDL148C Nucleolar protein physical 1 1 1 Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
RPL23A YBL087C Ribosomal 60S subunit protein L23A genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex physical 1 1 1 Affinity Capture-MS
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Positive Genetic
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Negative Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity physical 1 1 1 Affinity Capture-MS
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis physical 1 1 1 Two-hybrid
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
PYC1 YGL062W Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 1 1 1 Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Growth Defect
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein physical 1 1 1 Affinity Capture-Western
HSL7 YBR133C Protein arginine N-methyltransferase genetic 1 1 1 Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Positive Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Negative Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Negative Genetic
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Negative Genetic
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity physical 1 1 1 Affinity Capture-MS
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Negative Genetic
CCE1 YKL011C Mitochondrial cruciform cutting endonuclease genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Negative Genetic
MFB1 YDR219C Mitochondria-associated F-box protein genetic 1 1 1 Positive Genetic
LSM8 YJR022W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
ISA1 YLL027W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DDI1 YER143W Aspartic-type endopeptidase physical 1 1 1 Affinity Capture-Western
DID4 YKL002W Class E Vps protein of the ESCRT-III complex genetic 1 1 1 Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
NUP157 YER105C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
CSM3 YMR048W Replication fork associated factor physical 1 1 1 Affinity Capture-MS
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
DON1 YDR273W Meiosis-specific component of the spindle pole body physical 1 1 1 Two-hybrid
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Positive Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-Western
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Negative Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 1 1 1 Positive Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Positive Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
MEI4 YER044C-A Meiosis-specific protein involved in forming DSBs genetic 1 1 1 Negative Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 1 1 1 Negative Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Negative Genetic
BAT2 YJR148W Cytosolic branched-chain amino acid (BCAA) aminotransferase genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 1 1 1 Negative Genetic
HUB1 YNR032C-A Ubiquitin-like protein modifier genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs genetic 1 1 1 Positive Genetic
EUC1 YMR111C Sequence-specific DNA binding protein genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Negative Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
EXG2 YDR261C Exo-1,3-beta-glucanase genetic 1 1 1 Positive Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
NDJ1 YOL104C Protein that regulates meiotic SPB cohesion and telomere clustering genetic 1 1 1 Positive Genetic
ESBP6 YNL125C Protein with similarity to monocarboxylate permeases genetic 1 1 1 Negative Genetic
ERG7 YHR072W Lanosterol synthase genetic 1 1 1 Negative Genetic
PHO11 YAR071W One of three repressible acid phosphatases genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 1 1 1 Negative Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
APS1 YLR170C Small subunit of the clathrin-associated adaptor complex AP-1 genetic 1 1 1 Positive Genetic
NCW2 YLR194C GPI-anchored protein involved in cell wall remodeling genetic 1 1 1 Negative Genetic
ACL4 YDR161W Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b genetic 1 1 1 Negative Genetic
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ISR1 YPR106W Predicted protein kinase genetic 1 1 1 Negative Genetic
PMT6 YGR199W Protein O-mannosyltransferase genetic 1 1 1 Positive Genetic
AAD4 YDL243C Putative aryl-alcohol dehydrogenase genetic 1 1 1 Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 1 1 1 Negative Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Positive Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
HXT4 YHR092C High-affinity glucose transporter genetic 1 1 1 Negative Genetic
PHO8 YDR481C Repressible vacuolar alkaline phosphatase genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
RBS1 YDL189W Protein involved in assembly of the RNA Pol III complex genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Positive Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
MTO1 YGL236C Mitochondrial protein genetic 1 1 1 Positive Genetic
MTC3 YGL226W Protein of unknown function genetic 1 1 1 Negative Genetic
GLD1 YPR109W Component of Dsc E3 ligase complex in Golgi and endosomes genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
MSS2 YDL107W Peripherally bound inner membrane protein of the mitochondrial matrix genetic 1 1 1 Positive Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
PIC2 YER053C Mitochondrial copper and phosphate carrier genetic 1 1 1 Negative Genetic
BCD1 YHR040W Essential protein required for the accumulation of box C/D snoRNA genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Positive Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic