Standard name Systematic name Name description Description
RAD5 YLR032W DNA helicase/Ubiquitin ligase DNA helicase/Ubiquitin ligase; involved in error-free DNA damage tolerance (DDT), replication fork regression during postreplication repair by template switching, and error-prone translesion synthesis; required for UV and MMS-associated unequal sister chromatid exchange (SCE) but not for double-strand break associated unequal SCE; promotes synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p; human homolog HLTF can complement yeast null mutant
Visualize the interactome of RAD5
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 36

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.547 0.402 0.606
Mito 0.060 0.609 0.381
Nucleus 0.242 0.109 0.077
Vac/Vac Memb 0.179 0.315 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 1520

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAD5 12 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD51 YER095W Strand exchange protein genetic 19 7 16 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Positive Genetic, Dosage Lethality, Dosage Rescue
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 18 5 15 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Negative Genetic, Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 14 6 11 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Dosage Lethality, Phenotypic Suppression, Dosage Rescue
POL32 YJR043C Third subunit of DNA polymerase delta genetic 13 4 9 Synthetic Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue, Dosage Lethality
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 13 3 9 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
UBC13 YDR092W E2 ubiquitin-conjugating enzyme physical 12 3 8 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid
REV1 YOR346W Deoxycytidyl transferase physical 12 5 7 Reconstituted Complex, Two-hybrid, Two-hybrid, Co-purification, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 12 3 7 Two-hybrid, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Two-hybrid, Biochemical Activity, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 11 5 10 Synthetic Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 11 5 9 Dosage Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Synthetic Rescue, Dosage Rescue, Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 10 5 10 Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Dosage Lethality, Positive Genetic
RAD17 YOR368W Checkpoint protein genetic 10 4 8 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality
RAD24 YER173W Checkpoint protein genetic 10 3 7 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 9 5 6 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic, Dosage Lethality
SIZ1 YDR409W SUMO E3 ligase genetic 8 3 7 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue
DDC1 YPL194W DNA damage checkpoint protein genetic 8 3 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 7 5 7 Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 7 4 7 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Dosage Rescue
RAD55 YDR076W Protein that stimulates strand exchange genetic 7 4 5 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Positive Genetic, Dosage Lethality
TSA1 YML028W Thioredoxin peroxidase genetic 7 3 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 6 4 6 Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Phenotypic Suppression
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 6 2 6 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 6 5 5 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Dosage Lethality
HSL1 YKL101W Nim1p-related protein kinase genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase physical 6 2 4 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 5 2 5 Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 5 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 5 5 4 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Positive Genetic, Dosage Lethality
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 5 4 4 Dosage Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 5 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Dosage Lethality
RAD57 YDR004W Protein that stimulates strand exchange genetic 5 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Dosage Lethality
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 5 2 4 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 4 3 4 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 4 3 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Dosage Lethality
BRE1 YDL074C E3 ubiquitin ligase genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 4 2 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase physical 4 2 3 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 3 3 3 Negative Genetic, Phenotypic Suppression, Dosage Lethality
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 3 3 3 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect
REV1 YOR346W Deoxycytidyl transferase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 3 2 Negative Genetic, Positive Genetic, Dosage Lethality
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 3 2 Synthetic Growth Defect, Negative Genetic, Positive Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 2 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 3 2 2 Negative Genetic, Negative Genetic, Dosage Lethality
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 3 2 2 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 3 2 2 Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PET20 YPL159C Mitochondrial protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 2 2 2 Negative Genetic, Dosage Lethality
NPL3 YDR432W RNA-binding protein genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Negative Genetic, Dosage Lethality
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 2 2 2 Synthetic Lethality, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Negative Genetic, Dosage Lethality
TOP3 YLR234W DNA Topoisomerase III genetic 2 2 2 Negative Genetic, Dosage Lethality
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 2 2 Synthetic Rescue, Dosage Lethality
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 2 1 2 Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 1 2 Positive Genetic, Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 2 1 2 Negative Genetic, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 1 2 Negative Genetic, Negative Genetic
YML020W YML020W Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 2 1 2 Negative Genetic, Negative Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 2 Negative Genetic, Negative Genetic
ALG9 YNL219C Mannosyltransferase, involved in N-linked glycosylation genetic 2 1 2 Negative Genetic, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 2 2 1 Affinity Capture-Western, Two-hybrid
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking genetic 2 1 1 Negative Genetic, Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SPO12 YHR152W Nucleolar protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
YSR3 YKR053C Dihydrosphingosine 1-phosphate phosphatase genetic 2 1 1 Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 1 Negative Genetic, Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 1 Negative Genetic, Negative Genetic
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Dosage Lethality
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Dosage Lethality
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Dosage Lethality
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Dosage Lethality
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Positive Genetic
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Phenotypic Enhancement
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Dosage Lethality
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Dosage Lethality
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Dosage Lethality
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Dosage Lethality
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Dosage Lethality
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Dosage Lethality
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Dosage Lethality
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 1 1 1 Dosage Lethality
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
IRR1 YIL026C Subunit of the cohesin complex genetic 1 1 1 Dosage Lethality
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
MAS1 YLR163C Beta subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Positive Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Dosage Lethality
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
MSH6 YDR097C Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Synthetic Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Dosage Lethality
ORC1 YML065W Largest subunit of the origin recognition complex physical 1 1 1 Affinity Capture-MS
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Dosage Lethality
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Rescue
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Dosage Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Dosage Lethality
PRP6 YBR055C Splicing factor genetic 1 1 1 Dosage Lethality
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 1 1 1 Dosage Lethality
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Synthetic Growth Defect
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Rescue
PRP38 YGR075C Unique component of the U4/U6.U5 tri-snRNP particle genetic 1 1 1 Dosage Lethality
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Phenotypic Enhancement
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
LSM12 YHR121W Protein of unknown function that may function in RNA processing physical 1 1 1 Affinity Capture-MS
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 1 1 1 Dosage Lethality
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Negative Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Dosage Lethality
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway genetic 1 1 1 Negative Genetic
ATG11 YPR049C Adapter protein for pexophagy and the Cvt targeting pathway genetic 1 1 1 Dosage Lethality
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
GAL7 YBR018C Galactose-1-phosphate uridyl transferase genetic 1 1 1 Dosage Lethality
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Phenotypic Enhancement
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Growth Defect
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Dosage Lethality
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
ELC1 YPL046C Elongin C, conserved among eukaryotes genetic 1 1 1 Synthetic Growth Defect
CPR3 YML078W Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-Western
DEF1 YKL054C RNAPII degradation factor genetic 1 1 1 Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
CKI1 YLR133W Choline kinase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Synthetic Growth Defect
ERG11 YHR007C Lanosterol 14-alpha-demethylase genetic 1 1 1 Dosage Lethality
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
DAL82 YNL314W Positive regulator of allophanate inducible genes genetic 1 1 1 Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Dosage Lethality
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Dosage Lethality
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies genetic 1 1 1 Dosage Lethality
QCR6 YFR033C Subunit 6 of the ubiquinol cytochrome-c reductase complex genetic 1 1 1 Dosage Lethality
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 1 1 1 Positive Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Dosage Lethality
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Dosage Lethality
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Dosage Lethality
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Dosage Lethality
MCM1 YMR043W Transcription factor genetic 1 1 1 Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Dosage Lethality
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Dosage Lethality
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Dosage Lethality
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 1 1 1 Two-hybrid
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
UBI4 YLL039C Ubiquitin physical 1 1 1 Biochemical Activity
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Dosage Lethality
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Phenotypic Suppression
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Positive Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Lethality
SKS1 YPL026C Putative serine/threonine protein kinase genetic 1 1 1 Positive Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Synthetic Growth Defect
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
RRN11 YML043C Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response genetic 1 1 1 Negative Genetic
RGD1 YBR260C GTPase-activating protein (RhoGAP) for Rho3p and Rho4p genetic 1 1 1 Negative Genetic
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
YHL017W YHL017W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YHR050W-A YHR050W-A Protein of unknown function genetic 1 1 1 Negative Genetic
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 1 1 1 Synthetic Growth Defect
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Positive Genetic
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Positive Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Positive Genetic
STB4 YMR019W Putative transcription factor genetic 1 1 1 Negative Genetic
ZIP2 YGL249W Meiosis-specific protein genetic 1 1 1 Positive Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 1 1 1 Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination genetic 1 1 1 Dosage Lethality
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Dosage Lethality
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Dosage Lethality
RSM19 YNR037C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
RTC6 YPL183W-A Protein involved in translation genetic 1 1 1 Dosage Lethality
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Dosage Lethality
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Dosage Lethality
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 1 1 1 Dosage Lethality
SKG3 YLR187W Protein of unknown function genetic 1 1 1 Dosage Lethality
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Dosage Lethality
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Dosage Lethality
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Dosage Lethality
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Dosage Lethality
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Dosage Lethality
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Dosage Lethality
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Dosage Lethality
UBC8 YEL012W Ubiquitin-conjugating enzyme that regulates gluconeogenesis genetic 1 1 1 Dosage Lethality
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Dosage Lethality
YDR514C YDR514C Protein of unknown function that localizes to mitochondria genetic 1 1 1 Dosage Lethality
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Dosage Lethality
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Dosage Lethality
TAG1 YLR173W Vacuolar membrane protein involved in termination of autophagy genetic 1 1 1 Dosage Lethality
YNL058C YNL058C Putative protein of unknown function genetic 1 1 1 Dosage Lethality
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Dosage Lethality
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Dosage Lethality
SEC21 YNL287W Gamma subunit of coatomer genetic 1 1 1 Dosage Lethality
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Dosage Lethality
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Dosage Lethality
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Dosage Lethality
SPC25 YER018C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Dosage Lethality
SPC3 YLR066W Subunit of signal peptidase complex genetic 1 1 1 Dosage Lethality
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Dosage Lethality
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Dosage Lethality
GAL10 YBR019C UDP-glucose-4-epimerase genetic 1 1 1 Dosage Lethality
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Dosage Lethality
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Synthetic Growth Defect
RAD2 YGR258C Single-stranded DNA endonuclease genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Dosage Lethality
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Synthetic Growth Defect
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 PCA
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Positive Genetic
PRP16 YKR086W DEAH-box RNA helicase genetic 1 1 1 Dosage Lethality
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Growth Defect
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Dosage Lethality
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 1 1 1 Negative Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Dosage Lethality
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Dosage Lethality
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Dosage Lethality
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Positive Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
NTH2 YBR001C Putative neutral trehalase, required for thermotolerance genetic 1 1 1 Dosage Lethality
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta physical 1 1 1 Two-hybrid
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Dosage Lethality
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Negative Genetic
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
DDP1 YOR163W Diadenosine and diphosphoinositol polyphosphate phosphatase genetic 1 1 1 Dosage Lethality
GUT2 YIL155C Mitochondrial glycerol-3-phosphate dehydrogenase genetic 1 1 1 Dosage Lethality
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p physical 1 1 1 Two-hybrid
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Dosage Lethality
COA2 YPL189C-A Cytochrome oxidase assembly factor genetic 1 1 1 Dosage Lethality
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Dosage Lethality
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Dosage Lethality
MIX23 YBL107C Mitochondrial intermembrane space protein of unknown function genetic 1 1 1 Dosage Lethality
MRM2 YGL136C Mitochondrial 2' O-ribose methyltransferase genetic 1 1 1 Negative Genetic
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 1 1 1 Dosage Lethality
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
NMA111 YNL123W Serine protease and general molecular chaperone genetic 1 1 1 Positive Genetic
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 1 1 1 Positive Genetic
IDP2 YLR174W Cytosolic NADP-specific isocitrate dehydrogenase genetic 1 1 1 Dosage Lethality
PET117 YER058W Assembly factor that couples heme a synthesis to complex IV assembly genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
PPT2 YPL148C Phosphopantetheine:protein transferase (PPTase) genetic 1 1 1 Negative Genetic
PAU14 YIL176C Protein of unknown function genetic 1 1 1 Negative Genetic