Standard name Systematic name Name description Description
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component 19S proteasome regulatory particle lid subcomplex component; role in Ub-dependent proteolysis and proteasome stability; involved in TREX-2 mediated mRNA export, and in the prevention of transcription-associated genome instability; ubiquitinated by Nedd4-like E3-ligase, Rsp5p; human ortholog DSS1, a BRCA1 binding protein implicated in cancer, complements the yeast null; drives trinucleotide repeat expansion; protein abundance increases in response to DNA replication stress
Visualize the interactome of SEM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.910 0.881 0.842
Vac/Vac Memb 0.069 0.083 0.094
Nucleolus NaN NaN 0.081

GFP localization & abundance

GFP localization GFP abundance
nucleus 5590

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SEM1 5 1 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 12 3 10 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 11 5 9 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 9 1 7 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 8 2 8 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 8 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 8 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 7 2 7 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
THP1 YOL072W Nuclear pore-associated protein physical 7 3 5 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Affinity Capture-MS
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 6 2 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 6 4 5 Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
YPT6 YLR262C Rab family GTPase genetic 5 1 5 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
SAC3 YDR159W mRNA export factor physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Co-crystal Structure, Co-purification
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 5 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 5 2 4 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 5 2 4 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p physical 4 3 4 Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
RPN2 YIL075C Subunit of the 26S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 2 4 Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 4 3 3 Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Synthetic Growth Defect
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 2 3 Positive Genetic, Positive Genetic, Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 3 2 3 Positive Genetic, Positive Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 3 2 2 Positive Genetic, Synthetic Rescue, Synthetic Rescue
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBP1 YDL122W Ubiquitin-specific protease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CDC73 YLR418C Component of the Paf1p complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 2 2 2 Synthetic Lethality, Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 2 Negative Genetic, Positive Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 2 2 Positive Genetic, Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 2 2 2 Positive Genetic, Negative Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 2 2 2 Positive Genetic, Synthetic Rescue
THP3 YPR045C Protein that may have a role in transcription elongation physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 2 2 2 Negative Genetic, Positive Genetic
TUB4 YLR212C Gamma-tubulin genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 2 2 2 Negative Genetic, Dosage Growth Defect
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 1 2 Negative Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 2 Positive Genetic, Positive Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 2 1 2 Positive Genetic, Positive Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 2 1 2 Negative Genetic, Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 2 1 2 Negative Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 1 2 Negative Genetic, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
HHF1 YBR009C Histone H4 genetic 2 1 2 Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 2 Positive Genetic, Positive Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
HTA1 YDR225W Histone H2A genetic 2 1 2 Negative Genetic, Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PIL1 YGR086C Eisosome core component genetic 2 1 2 Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 2 1 2 Positive Genetic, Positive Genetic
AHP1 YLR109W Thiol-specific peroxiredoxin genetic 2 1 2 Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 2 1 2 Negative Genetic, Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 2 1 2 Positive Genetic, Positive Genetic
MSN5 YDR335W Karyopherin genetic 2 1 2 Negative Genetic, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 2 1 2 Negative Genetic, Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Positive Genetic, Positive Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Positive Genetic, Positive Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 2 1 2 Negative Genetic, Negative Genetic
SCO1 YBR037C Copper-binding protein of mitochondrial inner membrane genetic 2 1 2 Negative Genetic, Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 2 1 2 Positive Genetic, Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins genetic 2 1 2 Negative Genetic, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 2 1 2 Positive Genetic, Positive Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 2 1 2 Negative Genetic, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 2 1 2 Negative Genetic, Negative Genetic
YNL040W YNL040W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 2 1 2 Negative Genetic, Negative Genetic
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 2 1 2 Positive Genetic, Positive Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 1 2 Negative Genetic, Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 2 1 2 Positive Genetic, Positive Genetic
REG2 YBR050C Regulatory subunit of the Glc7p type-1 protein phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
SEC3 YER008C Subunit of the exocyst complex genetic 2 2 1 Dosage Rescue, Synthetic Rescue
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 2 2 1 Dosage Rescue, Synthetic Rescue
SEC15 YGL233W Essential 113 kDa subunit of the exocyst complex genetic 2 2 1 Dosage Rescue, Synthetic Rescue
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 2 2 1 Dosage Rescue, Synthetic Rescue
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 2 1 1 Positive Genetic, Positive Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 2 1 1 PCA, PCA
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 1 Negative Genetic, Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 2 1 1 Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 2 1 1 Negative Genetic, Negative Genetic
CDC53 YDL132W Cullin genetic 2 1 1 Negative Genetic, Negative Genetic
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 2 1 1 Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 1 Negative Genetic, Negative Genetic
PFS1 YHR185C Sporulation protein required for prospore membrane formation genetic 2 1 1 Negative Genetic, Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 2 1 1 Negative Genetic, Negative Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 2 1 1 Positive Genetic, Positive Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 2 1 1 Negative Genetic, Negative Genetic
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 2 1 1 Negative Genetic, Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 2 1 1 Negative Genetic, Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Lethality
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Positive Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
NOG1 YPL093W Putative GTPase genetic 1 1 1 Positive Genetic
RRP1 YDR087C Essential evolutionarily conserved nucleolar protein genetic 1 1 1 Positive Genetic
NOP9 YJL010C Essential subunit of U3-containing 90S preribosome genetic 1 1 1 Negative Genetic
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Positive Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Positive Genetic
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Positive Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Positive Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Positive Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Synthetic Lethality
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Dosage Rescue
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Positive Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Positive Genetic
HGH1 YGR187C Chaperone protein for translation factor eEF2 genetic 1 1 1 Positive Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Positive Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Positive Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase genetic 1 1 1 Negative Genetic
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 1 1 1 Affinity Capture-Western
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor genetic 1 1 1 Positive Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM4 YER112W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ADA2 YDR448W Transcription coactivator physical 1 1 1 Affinity Capture-Western
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRM1 YOR201C Ribose methyltransferase genetic 1 1 1 Positive Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Rescue
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 1 1 1 Phenotypic Enhancement
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
MGM101 YJR144W Protein with a role in mitochondrial DNA recombinational repair genetic 1 1 1 Positive Genetic
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Negative Genetic
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor physical 1 1 1 Affinity Capture-MS
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Positive Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex physical 1 1 1 Affinity Capture-MS
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase genetic 1 1 1 Positive Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 1 1 1 Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Positive Genetic
RAD51 YER095W Strand exchange protein genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Lethality
MTR3 YGR158C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Positive Genetic
REA1 YLR106C Huge dynein-related AAA-type ATPase (midasin) genetic 1 1 1 Negative Genetic
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase genetic 1 1 1 Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
ANP1 YEL036C Subunit of the alpha-1,6 mannosyltransferase complex genetic 1 1 1 Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex physical 1 1 1 Affinity Capture-MS
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Positive Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B genetic 1 1 1 Negative Genetic
EFB1 YAL003W Translation elongation factor 1 beta genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
FUN19 YAL034C Non-essential protein of unknown function genetic 1 1 1 Positive Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Phenotypic Enhancement
RIO2 YNL207W Essential serine kinase involved in the processing of 20S pre-rRNA genetic 1 1 1 Positive Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
FKH1 YIL131C Forkhead family transcription factor genetic 1 1 1 Positive Genetic
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) genetic 1 1 1 Positive Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Positive Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-MS
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
MET30 YIL046W F-box protein containing five copies of the WD40 motif genetic 1 1 1 Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Phenotypic Suppression
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
IPA1 YJR141W Protein implicated in pre-mRNA processing and proteasomal degradation genetic 1 1 1 Negative Genetic
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 1 1 1 Negative Genetic
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
PPE1 YHR075C Protein with carboxyl methyl esterase activity genetic 1 1 1 Positive Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Synthetic Growth Defect
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 PCA
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Positive Genetic
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
AIR1 YIL079C Zinc knuckle protein genetic 1 1 1 Synthetic Lethality
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Negative Genetic
MIG1 YGL035C Transcription factor involved in glucose repression genetic 1 1 1 Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Synthetic Lethality
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
POL4 YCR014C DNA polymerase IV physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
SBH2 YER019C-A Ssh1p-Sss1p-Sbh2p complex component genetic 1 1 1 Synthetic Growth Defect
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Synthetic Rescue
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
RLP24 YLR009W Essential protein required for ribosomal large subunit biogenesis genetic 1 1 1 Positive Genetic
RFT1 YBL020W Membrane protein required for translocation of Man5GlcNac2-PP-Dol genetic 1 1 1 Positive Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-MS
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 1 1 1 Negative Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
MTR2 YKL186C mRNA transport regulator genetic 1 1 1 Synthetic Lethality
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Synthetic Growth Defect
SEC61 YLR378C Conserved ER protein translocation channel genetic 1 1 1 Negative Genetic
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Positive Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Positive Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Positive Genetic
BNR1 YIL159W Formin genetic 1 1 1 Positive Genetic
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Positive Genetic
DAL80 YKR034W Negative regulator of genes in multiple nitrogen degradation pathways genetic 1 1 1 Negative Genetic
HCH1 YNL281W Heat shock protein regulator genetic 1 1 1 Negative Genetic
HKR1 YDR420W Mucin family member that functions as an osmosensor in the HOG pathway genetic 1 1 1 Negative Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Synthetic Growth Defect
CHS5 YLR330W Component of the exomer complex genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Positive Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 1 1 1 Affinity Capture-Western
FLO8 YER109C Transcription factor genetic 1 1 1 Positive Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Negative Genetic
EUC1 YMR111C Sequence-specific DNA binding protein genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
ROY1 YMR258C GTPase inhibitor with similarity to F-box proteins genetic 1 1 1 Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
COQ10 YOL008W Coenzyme Q (ubiquinone) binding protein genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III physical 1 1 1 Affinity Capture-MS
UBP6 YFR010W Ubiquitin-specific protease physical 1 1 1 Affinity Capture-MS
TCB2 YNL087W ER protein involved in ER-plasma membrane tethering physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SQT1 YIR012W Specific assembly chaperone for ribosomal protein Rpl10p physical 1 1 1 Affinity Capture-MS
SLM2 YNL047C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Affinity Capture-Western
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Synthetic Lethality
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
SUV3 YPL029W ATP-dependent RNA helicase genetic 1 1 1 Dosage Rescue
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Negative Genetic
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Positive Genetic
SXM1 YDR395W Nuclear transport factor (karyopherin) genetic 1 1 1 Negative Genetic
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Positive Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Positive Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Positive Genetic
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Positive Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Negative Genetic
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation genetic 1 1 1 Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Synthetic Lethality
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Synthetic Lethality
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Positive Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 1 1 1 Negative Genetic
SPT23 YKL020C ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Positive Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
VAC8 YEL013W Vacuole-specific Myo2p receptor genetic 1 1 1 Negative Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Positive Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Positive Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Positive Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Positive Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Positive Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Positive Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
TRM11 YOL124C Catalytic subunit of adoMet-dependent tRNA methyltransferase complex genetic 1 1 1 Negative Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport genetic 1 1 1 Synthetic Growth Defect
SSA2 YLL024C HSP70 family ATP-binding protein genetic 1 1 1 Synthetic Growth Defect
YEL1 YBL060W Guanine nucleotide exchange factor specific for Arf3p genetic 1 1 1 Negative Genetic
TMH18 YPR098C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
DDR48 YMR173W DNA damage-responsive protein physical 1 1 1 Affinity Capture-MS
BNA1 YJR025C 3-hydroxyanthranilic acid dioxygenase genetic 1 1 1 Negative Genetic
HOB2 YPR117W Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
MMF1 YIL051C Mitochondrial protein required for transamination of isoleucine genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Positive Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
NPT1 YOR209C Nicotinate phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Positive Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Negative Genetic
GPI12 YMR281W ER membrane protein involved in the second step of GPI anchor assembly genetic 1 1 1 Negative Genetic
LAG1 YHL003C Ceramide synthase component genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Positive Genetic
SCD6 YPR129W Repressor of translation initiation genetic 1 1 1 Positive Genetic
OM14 YBR230C Mitochondrial outer membrane receptor for cytosolic ribosomes genetic 1 1 1 Negative Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 1 1 1 Negative Genetic
MAL13 YGR288W MAL-activator protein genetic 1 1 1 Negative Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
MET13 YGL125W Major isozyme of methylenetetrahydrofolate reductase genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Synthetic Lethality
SEC72 YLR292C Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
PIG2 YIL045W Putative type-1 protein phosphatase targeting subunit genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Positive Genetic