Standard name Systematic name Name description Description
HTB1 YDR224C Histone H2B Histone H2B; core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates reassembly after DNA replication, transcriptional activation, meiotic DSB formation and H3 methylation
Visualize the interactome of HTB1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 60

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.743 0.96 0.492
Mito 0.053 NaN 0.115
Nucleus 0.726 0.49 0.811
Cell Periphery NaN 0.23 NaN
Nucleolus NaN NaN 0.098

GFP localization & abundance

GFP localization GFP abundance
nucleus technical problem

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
HTB1 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
HTA1 YDR225W Histone H2A physical 16 4 15 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Co-purification, Co-purification, Co-purification, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-purification, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 11 3 9 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS
HTZ1 YOL012C Histone variant H2AZ physical 9 3 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins physical 9 3 6 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 7 2 7 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
HHF1 YBR009C Histone H4 physical 7 2 6 Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
HTA1 YDR225W Histone H2A genetic 6 3 6 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 6 4 5 Affinity Capture-MS, Affinity Capture-Western, Co-purification, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex
HHT1 YBR010W Histone H3 physical 5 3 5 Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
INO80 YGL150C Nucleosome spacing factor physical 5 2 4 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 4 4 4 Synthetic Growth Defect, Dosage Rescue, Dosage Growth Defect, Phenotypic Enhancement
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 4 3 4 Dosage Rescue, Negative Genetic, Phenotypic Suppression, Phenotypic Suppression
HTA2 YBL003C Histone H2A physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor genetic 4 3 3 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
HHF1 YBR009C Histone H4 genetic 4 3 3 Dosage Growth Defect, Positive Genetic, Positive Genetic, Synthetic Growth Defect
CSE4 YKL049C Centromeric histone H3-like protein physical 4 2 3 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
MCM2 YBL023C Protein involved in DNA replication physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS
HHT2 YNL031C Histone H3 genetic 4 3 2 Phenotypic Enhancement, Positive Genetic, Positive Genetic, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase physical 4 2 2 Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Biochemical Activity
CHZ1 YER030W Histone chaperone for Htz1p/H2A-H2B dimer physical 3 3 3 Affinity Capture-Western, Co-crystal Structure, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 3 1 3 Affinity Capture-RNA, Affinity Capture-RNA, Affinity Capture-RNA
SIR3 YLR442C Silencing protein physical 3 1 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
RKR1 YMR247C RING domain E3 ubiquitin ligase genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
HHF2 YNL030W Histone H4 genetic 3 3 2 Phenotypic Enhancement, Positive Genetic, Synthetic Growth Defect
ORC1 YML065W Largest subunit of the origin recognition complex physical 3 3 2 Affinity Capture-MS, Co-crystal Structure, Reconstituted Complex
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 3 2 Positive Genetic, Synthetic Rescue, Dosage Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 3 2 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
HIF1 YLL022C Non-essential component of the HAT-B histone acetyltransferase complex physical 3 2 2 Reconstituted Complex, Co-crystal Structure, Reconstituted Complex
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex physical 3 2 2 Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex physical 3 2 2 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
PER1 YCR044C Protein of the endoplasmic reticulum genetic 3 2 2 Negative Genetic, Synthetic Rescue, Synthetic Rescue
HHT1 YBR010W Histone H3 genetic 3 2 2 Positive Genetic, Positive Genetic, Synthetic Growth Defect
ARP5 YNL059C Nuclear actin-related protein involved in chromatin remodeling physical 3 2 2 Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS
FEN2 YCR028C Plasma membrane H+-pantothenate symporter genetic 3 2 2 Negative Genetic, Synthetic Rescue, Synthetic Rescue
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex physical 3 3 1 Affinity Capture-Western, Far Western, Reconstituted Complex
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) physical 3 2 1 Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 3 2 1 Positive Genetic, Positive Genetic, Phenotypic Enhancement
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 3 2 1 Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) physical 2 2 2 Biochemical Activity, Reconstituted Complex
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling physical 2 2 2 Affinity Capture-Western, Affinity Capture-Luminescence
HTA2 YBL003C Histone H2A genetic 2 2 2 Negative Genetic, Phenotypic Suppression
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex physical 2 2 2 Affinity Capture-Western, Reconstituted Complex
SIR3 YLR442C Silencing protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 2 2 Dosage Growth Defect, Phenotypic Enhancement
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
NHP6A YPR052C High-mobility group (HMG) protein physical 2 2 2 PCA, Reconstituted Complex
SWR1 YDR334W Swi2/Snf2-related ATPase physical 2 2 2 Reconstituted Complex, Co-crystal Structure
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 2 2 Synthetic Lethality, Dosage Rescue
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase physical 2 2 2 Reconstituted Complex, Co-crystal Structure
HHT2 YNL031C Histone H3 physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
BRE1 YDL074C E3 ubiquitin ligase regulation 2 1 2 qualitative western immunoblotting evidence, qualitative western immunoblotting evidence
HTB2 YBL002W Histone H2B physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPO31 YOR116C RNA polymerase III largest subunit C160 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling physical 2 2 1 Far Western, Two-hybrid
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 2 1 Negative Genetic, Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 1 Phenotypic Suppression, Synthetic Lethality
NHP6B YBR089C-A High-mobility group (HMG) protein physical 2 2 1 PCA, Reconstituted Complex
CTK3 YML112W Gamma subunit of C-terminal domain kinase I physical 2 2 1 Affinity Capture-Western, Reconstituted Complex
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 physical 2 1 1 Reconstituted Complex, Reconstituted Complex
KAP123 YER110C Karyopherin beta physical 2 1 1 Reconstituted Complex, Reconstituted Complex
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 2 1 1 Positive Genetic, Positive Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
ROM1 YGR070W Guanine nucleotide exchange factor (GEF) for Rho1p genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
PKC1 YBL105C Protein serine/threonine kinase genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SSD1 YDR293C Translational repressor genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
MKS1 YNL076W Pleiotropic negative transcriptional regulator genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SKT5 YBL061C Activator of Chs3p (chitin synthase III) during vegetative growth genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
SLZ1 YNL196C Sporulation-specific protein with a leucine zipper motif genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
STE13 YOR219C Dipeptidyl aminopeptidase genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 2 1 1 Positive Genetic, Positive Genetic
CHA1 YCL064C Catabolic L-serine (L-threonine) deaminase genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NHP6A YPR052C High-mobility group (HMG) protein regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
NHP6B YBR089C-A High-mobility group (HMG) protein regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression regulation 1 1 1 quantitative polymerase chain reaction evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription physical 1 1 1 Reconstituted Complex
DSN1 YIR010W Essential component of the outer kinetochore MIND complex physical 1 1 1 Affinity Capture-MS
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
ESF1 YDR365C Nucleolar protein involved in pre-rRNA processing physical 1 1 1 Affinity Capture-MS
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) physical 1 1 1 Affinity Capture-MS
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Growth Defect
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Positive Genetic
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 Reconstituted Complex
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Positive Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Reconstituted Complex
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex physical 1 1 1 Affinity Capture-MS
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
HGH1 YGR187C Chaperone protein for translation factor eEF2 physical 1 1 1 Affinity Capture-MS
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
BDF1 YLR399C BET family transcriptional regulator physical 1 1 1 Affinity Capture-MS
BUD20 YLR074C C2H2-type zinc finger protein required for ribosome assembly physical 1 1 1 Affinity Capture-MS
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Lethality
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex physical 1 1 1 Reconstituted Complex
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
COX4 YGL187C Subunit IV of cytochrome c oxidase physical 1 1 1 Affinity Capture-MS
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Reconstituted Complex
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking physical 1 1 1 Affinity Capture-MS
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Positive Genetic
HIS4 YCL030C Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase genetic 1 1 1 Phenotypic Suppression
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Synthetic Rescue
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Two-hybrid
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Affinity Capture-Western
ABF2 YMR072W Mitochondrial DNA-binding protein physical 1 1 1 Affinity Capture-MS
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes physical 1 1 1 Biochemical Activity
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
ECM30 YLR436C Protein of unknown function physical 1 1 1 Affinity Capture-MS
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor physical 1 1 1 Affinity Capture-MS
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity physical 1 1 1 Reconstituted Complex
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-MS
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 1 1 1 Negative Genetic
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-Western
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
MSH3 YCR092C Mismatch repair protein physical 1 1 1 Affinity Capture-MS
UTP7 YER082C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression physical 1 1 1 Affinity Capture-MS
INO4 YOL108C Transcription factor involved in phospholipid synthesis physical 1 1 1 Affinity Capture-MS
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm physical 1 1 1 Affinity Capture-MS
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) physical 1 1 1 Affinity Capture-MS
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 Affinity Capture-MS
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis physical 1 1 1 Affinity Capture-MS
SPT15 YER148W TATA-binding protein (TBP) physical 1 1 1 Affinity Capture-MS
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
KAP95 YLR347C Karyopherin beta physical 1 1 1 Affinity Capture-Western
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 1 1 1 Biochemical Activity
HTB2 YBL002W Histone H2B genetic 1 1 1 Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Growth Defect
IOC3 YFR013W Subunit of the Isw1a complex physical 1 1 1 Affinity Capture-MS
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling physical 1 1 1 Affinity Capture-MS
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
MOT1 YPL082C Essential protein involved in regulation of transcription physical 1 1 1 Affinity Capture-MS
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 1 1 1 Affinity Capture-MS
RSC3 YDR303C Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RSC2 YLR357W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TBF1 YPL128C Telobox-containing general regulatory factor physical 1 1 1 Affinity Capture-MS
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 1 1 1 Affinity Capture-MS
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 1 1 1 Affinity Capture-MS
PSY4 YBL046W Regulatory subunit of protein phosphatase PP4 physical 1 1 1 Affinity Capture-MS
SRM1 YGL097W Nucleotide exchange factor for Gsp1p physical 1 1 1 Affinity Capture-MS
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Rescue
NUC1 YJL208C Major mitochondrial nuclease physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
VPS75 YNL246W NAP family histone chaperone physical 1 1 1 Reconstituted Complex
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 1 1 1 Affinity Capture-MS
SRC1 YML034W Inner nuclear membrane protein physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-Western
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Reconstituted Complex
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains physical 1 1 1 Affinity Capture-Western
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Dosage Growth Defect
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex physical 1 1 1 Biochemical Activity
IGO1 YNL157W Protein required for initiation of G0 program physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
SPP1 YPL138C Subunit of COMPASS (Set1C) physical 1 1 1 Reconstituted Complex
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK physical 1 1 1 Affinity Capture-Western
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Biochemical Activity
SPB4 YFL002C Putative ATP-dependent RNA helicase physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-MS
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance physical 1 1 1 Affinity Capture-MS
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Affinity Capture-MS
RPB10 YOR210W RNA polymerase subunit ABC10-beta physical 1 1 1 Affinity Capture-MS
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Affinity Capture-MS
RPC10 YHR143W-A RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III physical 1 1 1 Affinity Capture-MS
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPC34 YNR003C RNA polymerase III subunit C34 physical 1 1 1 Affinity Capture-MS
RPB5 YBR154C RNA polymerase subunit ABC27 physical 1 1 1 Affinity Capture-MS
RPC53 YDL150W RNA polymerase III subunit C53 physical 1 1 1 Affinity Capture-MS
RTG2 YGL252C Sensor of mitochondrial dysfunction physical 1 1 1 Affinity Capture-MS
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 1 1 1 Affinity Capture-MS
RPC37 YKR025W RNA polymerase III subunit C37 physical 1 1 1 Affinity Capture-MS
RPC31 YNL151C RNA polymerase III subunit C31 physical 1 1 1 Affinity Capture-MS
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p physical 1 1 1 Affinity Capture-MS
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-MS
RAD16 YBR114W Nucleotide excision repair (NER) protein physical 1 1 1 Affinity Capture-MS
UME6 YDR207C Rpd3L histone deacetylase complex subunit physical 1 1 1 Affinity Capture-MS
XRS2 YDR369C FHA domain-containing component of the Mre11 complex physical 1 1 1 Affinity Capture-MS
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Affinity Capture-MS
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation physical 1 1 1 Affinity Capture-MS
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase physical 1 1 1 Affinity Capture-MS
YJL113W YJL113W Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
MRPL22 YNL177C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 1 1 1 Affinity Capture-MS
PRS5 YOL061W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
POL4 YCR014C DNA polymerase IV physical 1 1 1 Affinity Capture-MS
SGM1 YJR134C Protein of unknown function physical 1 1 1 Affinity Capture-MS
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
PIM1 YBL022C ATP-dependent Lon protease physical 1 1 1 Affinity Capture-MS
NSI1 YDR026C RNA polymerase I termination factor physical 1 1 1 Affinity Capture-MS
PRP8 YHR165C Component of U4/U6-U5 snRNP complex physical 1 1 1 Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 1 1 1 Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Synthetic Lethality
TOA2 YKL058W TFIIA small subunit physical 1 1 1 Affinity Capture-MS
RPC11 YDR045C RNA polymerase III subunit C11 physical 1 1 1 Affinity Capture-MS
RPC17 YJL011C RNA polymerase III subunit C17 physical 1 1 1 Affinity Capture-MS
MRM1 YOR201C Ribose methyltransferase physical 1 1 1 Affinity Capture-MS
SIP5 YMR140W Protein of unknown function physical 1 1 1 Affinity Capture-MS
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth physical 1 1 1 Affinity Capture-MS
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions physical 1 1 1 Affinity Capture-MS
MIP1 YOR330C Mitochondrial DNA polymerase gamma physical 1 1 1 Affinity Capture-MS
RPB8 YOR224C RNA polymerase subunit ABC14.5 physical 1 1 1 Affinity Capture-MS
RRN5 YLR141W Protein involved in transcription of rDNA by RNA polymerase I physical 1 1 1 Affinity Capture-MS
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex physical 1 1 1 Affinity Capture-MS
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
MED1 YPR070W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Reconstituted Complex
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SRB5 YGR104C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Reconstituted Complex
MED7 YOL135C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Reconstituted Complex
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Reconstituted Complex
RMP1 YLR145W Subunit of RNase MRP physical 1 1 1 Affinity Capture-RNA
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Positive Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation genetic 1 1 1 Positive Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Reconstituted Complex
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex physical 1 1 1 Reconstituted Complex
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit physical 1 1 1 Reconstituted Complex
IES6 YEL044W Component of the INO80 chromatin remodeling complex physical 1 1 1 Reconstituted Complex
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Reconstituted Complex
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Reconstituted Complex
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Reconstituted Complex
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation physical 1 1 1 Affinity Capture-MS
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Phenotypic Suppression
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex physical 1 1 1 Affinity Capture-Western
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex physical 1 1 1 Reconstituted Complex
SCM3 YDL139C Nonhistone component of centromeric chromatin physical 1 1 1 Reconstituted Complex
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) physical 1 1 1 Affinity Capture-Western
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Affinity Capture-Western
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
SSC1 YJR045C Hsp70 family ATPase physical 1 1 1 Affinity Capture-MS
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
VID30 YGL227W Central component of GID Complex, involved in FBPase degradation physical 1 1 1 Affinity Capture-MS
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase physical 1 1 1 Affinity Capture-MS
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
MPS3 YJL019W Nuclear envelope protein physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
PDP3 YLR455W Component of the NuA3b histone acetyltransferase complex physical 1 1 1 Affinity Capture-MS
MIF2 YKL089W Centromeric CDEIII region binding protein physical 1 1 1 Affinity Capture-MS
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation physical 1 1 1 Affinity Capture-MS
HTB1 YDR224C Histone H2B physical 1 1 1 Affinity Capture-MS
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall physical 1 1 1 Affinity Capture-MS
MES1 YGR264C Methionyl-tRNA synthetase physical 1 1 1 Affinity Capture-RNA
SWC5 YBR231C Component of the SWR1 complex physical 1 1 1 Reconstituted Complex
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Phenotypic Enhancement
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Phenotypic Enhancement
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Phenotypic Enhancement
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Phenotypic Enhancement
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Phenotypic Enhancement
STO1 YMR125W Large subunit of the nuclear mRNA cap-binding protein complex genetic 1 1 1 Synthetic Rescue
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Positive Genetic
PRM4 YPL156C Pheromone-regulated protein proposed to be involved in mating genetic 1 1 1 Positive Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Positive Genetic
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 1 1 1 Positive Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Positive Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Positive Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Positive Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Positive Genetic
KEX2 YNL238W Kexin, a subtilisin-like protease (proprotein convertase) genetic 1 1 1 Positive Genetic
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Positive Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
MBP1 YDL056W Transcription factor genetic 1 1 1 Positive Genetic
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Positive Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
NRP1 YDL167C Putative RNA binding protein of unknown function genetic 1 1 1 Positive Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Positive Genetic
YBR225W YBR225W Putative protein of unknown function genetic 1 1 1 Positive Genetic
MUP3 YHL036W Low affinity methionine permease genetic 1 1 1 Positive Genetic
VMR1 YHL035C Vacuolar membrane protein genetic 1 1 1 Positive Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Positive Genetic
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
POS5 YPL188W Mitochondrial NADH kinase genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
MRP51 YPL118W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
TIM13 YGR181W Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
PDX1 YGR193C E3-binding protein of the mitochondrial pyruvate dehydrogenase complex genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
MCT1 YOR221C Predicted malonyl-CoA:ACP transferase genetic 1 1 1 Negative Genetic
MNN1 YER001W Alpha-1,3-mannosyltransferase genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Negative Genetic
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
LOA1 YPR139C Lysophosphatidic acid acyltransferase genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
THR1 YHR025W Homoserine kinase genetic 1 1 1 Negative Genetic
VMA16 YHR026W Subunit c'' of the vacuolar ATPase genetic 1 1 1 Negative Genetic
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
UBP1 YDL122W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RRB1 YMR131C Specific assembly chaperone for ribosomal protein Rpl3p genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
MSK1 YNL073W Mitochondrial lysine-tRNA synthetase genetic 1 1 1 Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 1 1 1 Negative Genetic
MDJ2 YNL328C Constituent of the mitochondrial import motor genetic 1 1 1 Negative Genetic
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
KIN1 YDR122W S/T protein kinase genetic 1 1 1 Negative Genetic
LEU3 YLR451W Zinc-knuckle transcription factor, repressor and activator genetic 1 1 1 Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 1 1 1 Negative Genetic
YNL190W YNL190W Hydrophilin essential in desiccation-rehydration process genetic 1 1 1 Negative Genetic
PEX1 YKL197C AAA-peroxin genetic 1 1 1 Negative Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Negative Genetic
NAB6 YML117W Putative RNA-binding protein genetic 1 1 1 Negative Genetic
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Negative Genetic
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Negative Genetic
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
RIM13 YMR154C Calpain-like cysteine protease genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Negative Genetic
MRPL3 YMR024W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Phenotypic Suppression
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Phenotypic Suppression
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Rescue
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Synthetic Lethality
MSL1 YIR009W U2B component of U2 snRNP genetic 1 1 1 Synthetic Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Rescue
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Phenotypic Suppression
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Phenotypic Suppression
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Phenotypic Suppression
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor physical 1 1 1 Affinity Capture-MS
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector physical 1 1 1 Affinity Capture-MS
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Dosage Rescue
GIP2 YER054C Putative regulatory subunit of protein phosphatase Glc7p physical 1 1 1 Affinity Capture-MS
APE1 YKL103C Vacuolar aminopeptidase yscI physical 1 1 1 Affinity Capture-MS
BUD32 YGR262C Protein kinase genetic 1 1 1 Dosage Growth Defect
CTF13 YMR094W Subunit of the CBF3 complex physical 1 1 1 Reconstituted Complex
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Positive Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
CPA1 YOR303W Small subunit of carbamoyl phosphate synthetase genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Dosage Rescue
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Positive Genetic
CKI1 YLR133W Choline kinase physical 1 1 1 Affinity Capture-MS
ATP5 YDR298C Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
ARG3 YJL088W Ornithine carbamoyltransferase genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Dosage Rescue
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I physical 1 1 1 Affinity Capture-MS
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site physical 1 1 1 Affinity Capture-MS
CUB1 YPL260W Conserved fungal gene linked to DNA repair and proteasome function genetic 1 1 1 Positive Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
GIP3 YPL137C Cytoplasmic protein that regulates protein phosphatase 1 Glc7p physical 1 1 1 Affinity Capture-MS
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) physical 1 1 1 Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Synthetic Rescue
BNR1 YIL159W Formin physical 1 1 1 Affinity Capture-MS
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Negative Genetic
HSV2 YGR223C Phosphatidylinositol 3,5-bisphosphate-binding protein genetic 1 1 1 Positive Genetic
COQ3 YOL096C O-methyltransferase physical 1 1 1 Affinity Capture-MS
CAN1 YEL063C Plasma membrane arginine permease genetic 1 1 1 Positive Genetic
ERI1 YPL096C-A Endoplasmic reticulum membrane protein that binds and inhibits Ras2p genetic 1 1 1 Negative Genetic
AEP3 YPL005W Peripheral mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
HIS6 YIL020C Enzyme that catalyzes the fourth step in the histidine pathway genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
AIM23 YJL131C Mitochondrial translation initiation factor 3 (IF3, mIF3) genetic 1 1 1 Positive Genetic
BSC2 YDR275W Protein of unknown function involved in multidrug resistance genetic 1 1 1 Negative Genetic
HIS5 YIL116W Histidinol-phosphate aminotransferase genetic 1 1 1 Negative Genetic
DNF2 YDR093W Aminophospholipid translocase (flippase) physical 1 1 1 Affinity Capture-MS
HIT1 YJR055W Protein involved in C/D snoRNP assembly genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Positive Genetic
COX20 YDR231C Mitochondrial inner membrane protein physical 1 1 1 Affinity Capture-MS
HIS7 YBR248C Imidazole glycerol phosphate synthase genetic 1 1 1 Negative Genetic
GRS2 YPR081C Glycine-tRNA synthetase, not expressed under normal growth conditions physical 1 1 1 Affinity Capture-MS
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Negative Genetic
EXO5 YBR163W Mitochondrial 5'-3' exonuclease and sliding exonuclease physical 1 1 1 Affinity Capture-MS