Standard name Systematic name Name description Description
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p Subunit of MRX complex with Mre11p and Xrs2p; complex is involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining; forms nuclear foci upon DNA replication stress
Visualize the interactome of RAD50
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.922 0.875 0.714
Mito NaN 0.093 0.571
Vac/Vac Memb NaN 0.071 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 830

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAD50 9 2 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 34 7 29 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Co-localization, Co-localization, Affinity Capture-Western, Co-purification, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 12 2 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex physical 10 4 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 9 3 8 Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 9 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 9 3 8 Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 8 4 8 Positive Genetic, Phenotypic Enhancement, Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Positive Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 8 4 7 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality
POL32 YJR043C Third subunit of DNA polymerase delta genetic 8 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 7 5 7 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 7 5 7 Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality, Positive Genetic, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 7 5 6 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement
TSA1 YML028W Thioredoxin peroxidase genetic 7 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 6 4 6 Dosage Rescue, Dosage Rescue, Negative Genetic, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 6 3 6 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 6 2 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 6 2 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 6 4 4 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 6 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 5 3 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement
SAE2 YGL175C Endonuclease required for telomere elongation genetic 5 4 4 Dosage Lethality, Dosage Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 5 3 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 5 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 4 3 3 Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 4 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 4 2 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 3 3 3 Synthetic Lethality, Negative Genetic, Phenotypic Suppression
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 3 3 3 Phenotypic Enhancement, Negative Genetic, Phenotypic Suppression
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 2 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
UBP6 YFR010W Ubiquitin-specific protease genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 3 2 3 Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression
SPO13 YHR014W Meiotic regulator genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 3 3 2 Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 3 3 2 Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 3 3 2 Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 3 2 2 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
RIF2 YLR453C Protein that binds to the Rap1p C-terminus physical 3 2 2 Reconstituted Complex, Reconstituted Complex, Two-hybrid
TOP1 YOL006C Topoisomerase I genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 3 2 2 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SAE2 YGL175C Endonuclease required for telomere elongation physical 3 1 2 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 3 2 1 Affinity Capture-Western, Affinity Capture-Western, Protein-peptide
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 2 Synthetic Lethality, Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HSL1 YKL101W Nim1p-related protein kinase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 2 Synthetic Lethality, Negative Genetic
HHT1 YBR010W Histone H3 genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 2 2 2 Two-hybrid, FRET
TOP3 YLR234W DNA Topoisomerase III genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 2 2 Negative Genetic, Synthetic Lethality
STN1 YDR082W Telomere end-binding and capping protein genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
MCM10 YIL150C Essential chromatin-associated protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 1 2 Negative Genetic, Negative Genetic
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 genetic 2 1 2 Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 1 2 Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
PTC3 YBL056W Type 2C protein phosphatase (PP2C) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 2 1 2 Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 2 1 2 Negative Genetic, Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 1 2 Negative Genetic, Negative Genetic
SWC7 YLR385C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 2 Negative Genetic, Negative Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
NNF1 YJR112W Essential component of the outer kinetochore MIND complex physical 2 1 2 Two-hybrid, Two-hybrid
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 2 1 2 Negative Genetic, Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 2 1 2 Negative Genetic, Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 2 1 2 Negative Genetic, Negative Genetic
MIL1 YFL034W Predicted lipase genetic 2 1 2 Negative Genetic, Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 2 1 2 Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC40 YDR364C Pre-mRNA splicing factor genetic 1 1 1 Synthetic Growth Defect
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Positive Genetic
ECM2 YBR065C Pre-mRNA splicing factor physical 1 1 1 Affinity Capture-MS
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit physical 1 1 1 Affinity Capture-MS
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Growth Defect
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Synthetic Growth Defect
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex physical 1 1 1 Two-hybrid
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Negative Genetic
MUM2 YBR057C Protein essential for meiotic DNA replication and sporulation genetic 1 1 1 Negative Genetic
MAM33 YIL070C Acidic protein of the mitochondrial matrix physical 1 1 1 Affinity Capture-MS
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Rescue
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit physical 1 1 1 Affinity Capture-MS
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 1 1 1 Affinity Capture-MS
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Lethality
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Lethality
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Synthetic Lethality
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen physical 1 1 1 Affinity Capture-MS
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-RNA
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Synthetic Growth Defect
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
ECM10 YEL030W Heat shock protein of the Hsp70 family physical 1 1 1 Affinity Capture-MS
PDS1 YDR113C Securin genetic 1 1 1 Phenotypic Suppression
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Phenotypic Suppression
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Phenotypic Enhancement
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 1 1 1 Synthetic Rescue
REX2 YLR059C 3'-5' RNA exonuclease physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Affinity Capture-MS
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway physical 1 1 1 Affinity Capture-MS
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
SMC1 YFL008W Subunit of the multiprotein cohesin complex physical 1 1 1 Two-hybrid
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 1 1 1 Affinity Capture-MS
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex physical 1 1 1 Two-hybrid
RPC19 YNL113W RNA polymerase subunit AC19 physical 1 1 1 Two-hybrid
SSO1 YPL232W Plasma membrane t-SNARE physical 1 1 1 Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Protein-peptide
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Lethality
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Synthetic Lethality
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Synthetic Rescue
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 1 1 1 Negative Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Positive Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Positive Genetic
SUA5 YGL169W Protein involved in threonylcarbamoyl adenosine biosynthesis genetic 1 1 1 Phenotypic Enhancement
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Growth Defect
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Synthetic Lethality
SIR3 YLR442C Silencing protein genetic 1 1 1 Synthetic Growth Defect
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Synthetic Growth Defect
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Growth Defect
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Synthetic Growth Defect
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Synthetic Growth Defect
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Dosage Growth Defect
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Synthetic Growth Defect
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
RSC30 YHR056C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RIM2 YBR192W Mitochondrial pyrimidine nucleotide transporter genetic 1 1 1 Dosage Rescue
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Synthetic Growth Defect
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Lethality
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Synthetic Growth Defect
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 1 1 1 Synthetic Growth Defect
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
POL4 YCR014C DNA polymerase IV genetic 1 1 1 Phenotypic Enhancement
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
GRX5 YPL059W Glutathione-dependent oxidoreductase genetic 1 1 1 Synthetic Growth Defect
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Lethality
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Phenotypic Suppression
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Synthetic Lethality
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Positive Genetic
HTL1 YCR020W-B Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge physical 1 1 1 Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
IES6 YEL044W Component of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
ELO3 YLR372W Elongase genetic 1 1 1 Phenotypic Enhancement
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Lethality
NRG2 YBR066C Transcriptional repressor genetic 1 1 1 Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Synthetic Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 genetic 1 1 1 Synthetic Growth Defect
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Growth Defect
MLS1 YNL117W Malate synthase, enzyme of the glyoxylate cycle genetic 1 1 1 Synthetic Lethality
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase physical 1 1 1 Two-hybrid
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Growth Defect
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
AIM26 YKL037W Protein of unknown function genetic 1 1 1 Negative Genetic
IDP1 YDL066W Mitochondrial NADP-specific isocitrate dehydrogenase physical 1 1 1 Affinity Capture-MS
OGG1 YML060W Nuclear and mitochondrial glycosylase/lyase genetic 1 1 1 Phenotypic Enhancement
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Lethality
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Synthetic Growth Defect
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Positive Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 1 1 1 Phenotypic Enhancement
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Growth Defect
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
PGC1 YPL206C Phosphatidylglycerol phospholipase C genetic 1 1 1 Negative Genetic
HNT3 YOR258W DNA 5' AMP hydrolase involved in DNA repair genetic 1 1 1 Synthetic Growth Defect
PAU7 YAR020C Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic