Standard name Systematic name Name description Description
CLB2 YPR119W B-type cyclin involved in cell cycle progression B-type cyclin involved in cell cycle progression; also involved in response to DNA damage; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome; CLB2 has a paralog, CLB1, that arose from the whole genome duplication
Visualize the interactome of CLB2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G2 100

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.682 0.572 0.682
Mito 0.273 NaN 0.101
Nucleus 0.136 0.317 0.236
Vac/Vac Memb NaN 0.083 NaN

GFP localization & abundance

GFP localization GFP abundance
ambiguous, nucleus 339

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
CLB2 1 8 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 28 5 26 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Co-purification, Affinity Capture-Western, Co-purification, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Reconstituted Complex, Reconstituted Complex
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) physical 12 3 11 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 11 3 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 10 3 8 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 10 2 8 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 9 4 4 Dosage Rescue, Dosage Rescue, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 8 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 8 6 6 Dosage Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Negative Genetic, Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 8 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 8 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) physical 7 5 5 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, FRET
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 7 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition physical 6 4 6 Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 6 4 6 Dosage Lethality, Dosage Lethality, Dosage Rescue, Synthetic Lethality, Dosage Growth Defect, Synthetic Lethality
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor physical 6 3 6 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
CIN8 YEL061C Bipolar kinesin motor protein genetic 6 2 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
CLB3 YDL155W B-type cyclin involved in cell cycle progression genetic 6 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 6 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 6 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 5 3 5 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 5 3 5 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 5 3 5 Dosage Lethality, Dosage Rescue, Dosage Lethality, Synthetic Growth Defect, Dosage Rescue
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 5 4 4 Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression, Positive Genetic, Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication physical 5 3 4 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
ASF1 YJL115W Nucleosome assembly factor genetic 5 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 5 2 4 Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 4 3 4 Dosage Lethality, Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Enhancement
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 4 3 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-Western, Two-hybrid
CIK1 YMR198W Kinesin-associated protein genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 4 3 2 Negative Genetic, Negative Genetic, Synthetic Rescue, Phenotypic Suppression
NUM1 YDR150W Protein required for nuclear migration genetic 4 1 2 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
XBP1 YIL101C Transcriptional repressor regulation 3 3 3 chromatin immunoprecipitation-chip evidence, reverse transcription polymerase chain reaction evidence, transcript expression evidence
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 3 3 3 Dosage Lethality, Synthetic Growth Defect, Negative Genetic
PDS1 YDR113C Securin genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Dosage Growth Defect
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 3 3 3 Dosage Rescue, Negative Genetic, Synthetic Growth Defect
RAD51 YER095W Strand exchange protein genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 3 2 3 Dosage Lethality, Dosage Lethality, Phenotypic Enhancement
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) physical 3 2 3 Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 3 2 3 Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 3 2 3 Dosage Lethality, Dosage Lethality, Dosage Growth Defect
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 3 2 3 Dosage Rescue, Dosage Rescue, Dosage Growth Defect
RAD52 YML032C Protein involved in homologous recombination genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 3 2 3 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 3 3 2 Phenotypic Suppression, Dosage Growth Defect, Phenotypic Enhancement
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 3 3 2 Negative Genetic, Phenotypic Enhancement, Dosage Growth Defect
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 3 3 2 Synthetic Growth Defect, Phenotypic Suppression, Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NDD1 YOR372C Transcriptional activator essential for nuclear division physical 3 2 1 PCA, Affinity Capture-Western, Affinity Capture-Western
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 2 2 Dosage Rescue, Dosage Lethality
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 Affinity Capture-MS, Co-purification
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
SRP1 YNL189W Karyopherin alpha homolog physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 2 2 Dosage Lethality, Synthetic Growth Defect
FKH1 YIL131C Forkhead family transcription factor genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
FKH2 YNL068C Forkhead family transcription factor genetic 2 2 2 Dosage Rescue, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MPS1 YDL028C Dual-specificity kinase genetic 2 2 2 Dosage Lethality, Positive Genetic
XBP1 YIL101C Transcriptional repressor genetic 2 2 2 Synthetic Rescue, Dosage Lethality
HTZ1 YOL012C Histone variant H2AZ genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
HSL7 YBR133C Protein arginine N-methyltransferase genetic 2 2 2 Dosage Rescue, Negative Genetic
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 2 2 2 Dosage Lethality, Synthetic Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
CHL1 YPL008W Probable DNA helicase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Negative Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
LDB18 YLL049W Component of the dynactin complex genetic 2 1 2 Positive Genetic, Positive Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 2 2 1 Reconstituted Complex, Two-hybrid
NET1 YJL076W Core subunit of the RENT complex genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 2 2 1 Synthetic Rescue, Dosage Lethality
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 2 2 1 Dosage Rescue, Synthetic Lethality
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 1 Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
HIR2 YOR038C Subunit of HIR nucleosome assembly complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
FKH2 YNL068C Forkhead family transcription factor physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SPA2 YLL021W Component of the polarisome genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
HHT1 YBR010W Histone H3 genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 2 1 1 Negative Genetic, Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 1 Negative Genetic, Negative Genetic
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels genetic 2 1 1 Negative Genetic, Negative Genetic
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 2 1 1 Negative Genetic, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 1 1 Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 1 1 Negative Genetic, Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 2 1 1 Negative Genetic, Negative Genetic
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AFT2 YPL202C Iron-regulated transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TFC7 YOR110W RNA pol III transcription initiation factor complex (TFIIIC) subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RGM1 YMR182C Putative zinc finger DNA binding transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes regulation 1 1 1 DNA to cDNA expression microarray evidence
NDD1 YOR372C Transcriptional activator essential for nuclear division regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MCM1 YMR043W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Negative Genetic
AMN1 YBR158W Modulator of cell separation and mitotic exit genetic 1 1 1 Dosage Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Dosage Lethality
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Negative Genetic
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Dosage Lethality
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis physical 1 1 1 Affinity Capture-Western
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Synthetic Rescue
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Two-hybrid
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Two-hybrid
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA physical 1 1 1 Two-hybrid
NEL1 YHR035W Activator of Sar1p GTPase activity physical 1 1 1 Two-hybrid
MRPL50 YNR022C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Two-hybrid
DBP1 YPL119C ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Affinity Capture-MS
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 1 1 1 Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 1 1 1 Affinity Capture-MS
SSA3 YBL075C ATPase involved in protein folding and the response to stress physical 1 1 1 Affinity Capture-MS
SSA4 YER103W Heat shock protein that is highly induced upon stress physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
SYP1 YCR030C Negative regulator of WASP-Arp23 complex physical 1 1 1 Affinity Capture-MS
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-MS
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 Affinity Capture-MS
YLL054C YLL054C Putative protein of unknown function with similarity to Pip2p physical 1 1 1 Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-Western
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 1 1 1 Affinity Capture-Western
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors physical 1 1 1 Affinity Capture-MS
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Synthetic Growth Defect
KEL1 YHR158C Protein required for proper cell fusion and cell morphology physical 1 1 1 Affinity Capture-MS
CUE5 YOR042W Ubiquitin-binding protein physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response physical 1 1 1 Affinity Capture-Western
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Biochemical Activity
MCM3 YEL032W Protein involved in DNA replication physical 1 1 1 Biochemical Activity
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase physical 1 1 1 Biochemical Activity
KIN82 YCR091W Putative serine/threonine protein kinase physical 1 1 1 Biochemical Activity
SHE2 YKL130C RNA-binding protein that binds specific mRNAs and interacts with She3p physical 1 1 1 Affinity Capture-RNA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
SAE2 YGL175C Endonuclease required for telomere elongation physical 1 1 1 Affinity Capture-Western
WHI3 YNL197C RNA binding protein that modulates mRNA stability physical 1 1 1 Protein-RNA
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Phenotypic Suppression
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein physical 1 1 1 Affinity Capture-MS
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p physical 1 1 1 Affinity Capture-MS
MUK1 YPL070W Guanine nucleotide exchange factor (GEF) physical 1 1 1 Affinity Capture-MS
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Affinity Capture-MS
NUP82 YJL061W Linker nucleoporin component of the nuclear pore complex (NPC) physical 1 1 1 Affinity Capture-MS
EPO1 YMR124W Protein involved in septin-ER tethering physical 1 1 1 Affinity Capture-MS
HOF1 YMR032W F-BAR protein that regulates actin cytoskeleton organization physical 1 1 1 Two-hybrid
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Phenotypic Suppression
STE5 YDR103W Pheromone-responsive MAPK scaffold protein physical 1 1 1 Affinity Capture-Western
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 1 1 1 Affinity Capture-Western
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Rescue
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion physical 1 1 1 Biochemical Activity
INN1 YNL152W Essential protein that associates with contractile actomyosin ring physical 1 1 1 Affinity Capture-Western
IPL1 YPL209C Aurora kinase of chromosomal passenger complex physical 1 1 1 Biochemical Activity
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 1 1 1 Affinity Capture-Western
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 1 1 1 Biochemical Activity
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Phenotypic Enhancement
FIN1 YDR130C Spindle pole body-related intermediate filament protein physical 1 1 1 Biochemical Activity
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) physical 1 1 1 Biochemical Activity
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 Biochemical Activity
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Biochemical Activity
LRE1 YCL051W Protein involved in control of cell wall structure and stress response physical 1 1 1 Affinity Capture-Western
DOC1 YGL240W Processivity factor physical 1 1 1 Protein-peptide
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 1 1 1 Affinity Capture-Western
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Dosage Lethality
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Synthetic Rescue
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Phenotypic Enhancement
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Phenotypic Enhancement
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Dosage Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Dosage Lethality
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 1 1 1 Synthetic Rescue
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Positive Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Positive Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Positive Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Positive Genetic
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Positive Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Dosage Rescue
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
TUB3 YML124C Alpha-tubulin genetic 1 1 1 Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
PLC1 YPL268W Phospholipase C genetic 1 1 1 Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Positive Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
CQD2 YLR253W Mitochondrial protein involved in lipid homeostasis genetic 1 1 1 Positive Genetic
PCL8 YPL219W Cyclin genetic 1 1 1 Positive Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Phenotypic Suppression
CLB4 YLR210W B-type cyclin involved in cell cycle progression genetic 1 1 1 Synthetic Lethality
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Synthetic Growth Defect
KIP1 YBL063W Kinesin-related motor protein genetic 1 1 1 Synthetic Lethality
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Synthetic Lethality
MSN5 YDR335W Karyopherin genetic 1 1 1 Dosage Growth Defect
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Synthetic Growth Defect
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Rescue
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Rescue
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Synthetic Growth Defect
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Synthetic Rescue
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Dosage Growth Defect
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Positive Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Positive Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
MCM6 YGL201C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Negative Genetic
GPN3 YLR243W Putative GTPase with a role in biogenesis of RNA pol II and polIII genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
MRX10 YDR282C Mitochondrial inner membrane protein of unknown function genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Dosage Lethality
SIP4 YJL089W C6 zinc cluster transcriptional activator genetic 1 1 1 Dosage Lethality
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Dosage Lethality
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Dosage Lethality
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Dosage Lethality
TOG1 YER184C Transcriptional activator of oleate genes genetic 1 1 1 Dosage Lethality
NRG2 YBR066C Transcriptional repressor genetic 1 1 1 Dosage Lethality
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Negative Genetic
YMR230W-A YMR230W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Positive Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Positive Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Phenotypic Enhancement
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Positive Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Synthetic Growth Defect
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 1 1 1 Positive Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Biochemical Activity
CLB1 YGR108W B-type cyclin involved in cell cycle progression physical 1 1 1 Affinity Capture-MS
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Negative Genetic
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator genetic 1 1 1 Dosage Lethality
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
ADK2 YER170W Mitochondrial adenylate kinase genetic 1 1 1 Positive Genetic