Standard name Systematic name Name description Description
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid Essential, non-ATPase regulatory subunit of the 26S proteasome lid; required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion; protein abundance increases in response to DNA replication stress
Visualize the interactome of RPN6
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Nucleus 0.917 0.854 0.850
Vac/Vac Memb 0.111 0.113 0.099
Nucleolus NaN 0.060 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 16800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RPN6 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 27 4 24 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Reconstituted Complex, Co-purification
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 18 5 18 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Two-hybrid, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, PCA
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 11 4 10 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-Western
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 10 4 9 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, PCA, Affinity Capture-Western, Affinity Capture-Western
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 10 3 9 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 9 4 7 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 9 3 7 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor physical 9 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 8 4 8 Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome physical 5 2 4 Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 5 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 5 2 3 Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic, Positive Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 4 2 4 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 2 2 Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 2 2 Positive Genetic, Positive Genetic, Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 4 2 2 Synthetic Haploinsufficiency, Synthetic Haploinsufficiency, Negative Genetic, Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UBP6 YFR010W Ubiquitin-specific protease physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
ECM29 YHL030W Scaffold protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 2 2 Positive Genetic, Positive Genetic, Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 3 2 2 Positive Genetic, Positive Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 2 2 2 Positive Genetic, Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 2 2 Positive Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Synthetic Lethality, Positive Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Negative Genetic, Synthetic Lethality
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Negative Genetic, Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 2 1 2 Negative Genetic, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 2 1 2 Negative Genetic, Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 2 1 2 Positive Genetic, Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEC53 YFL045C Phosphomannomutase genetic 2 1 2 Negative Genetic, Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 2 1 2 Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 2 Negative Genetic, Negative Genetic
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 2 1 2 Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 2 1 2 Negative Genetic, Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 1 2 Negative Genetic, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 1 2 Negative Genetic, Negative Genetic
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 2 1 2 Negative Genetic, Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 2 1 2 Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 2 Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 1 2 Positive Genetic, Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 1 Positive Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 2 1 Positive Genetic, Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 2 2 1 Positive Genetic, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 2 1 Positive Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 1 Positive Genetic, Positive Genetic
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 2 1 1 Negative Genetic, Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 1 Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 1 1 Negative Genetic, Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 1 1 Negative Genetic, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 1 Negative Genetic, Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 2 1 1 Negative Genetic, Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 2 1 1 Negative Genetic, Negative Genetic
YJU2 YKL095W Essential protein required for pre-mRNA splicing genetic 2 1 1 Negative Genetic, Negative Genetic
TAF9 YMR236W Subunit (17 kDa) of TFIID and SAGA complexes genetic 2 1 1 Negative Genetic, Negative Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 2 1 1 Negative Genetic, Negative Genetic
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 2 1 1 Negative Genetic, Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 1 1 Negative Genetic, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 1 Negative Genetic, Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 1 1 Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 1 Negative Genetic, Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 1 1 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Positive Genetic, Positive Genetic
PRP4 YPR178W Splicing factor genetic 2 1 1 Negative Genetic, Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 1 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 1 Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 2 1 1 Negative Genetic, Negative Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 2 1 1 Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 2 1 1 Negative Genetic, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 2 1 1 Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 1 Negative Genetic, Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 2 1 1 Negative Genetic, Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 1 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 1 1 Negative Genetic, Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 2 1 1 Negative Genetic, Negative Genetic
PAM16 YJL104W Subunit of the import motor (PAM complex) genetic 2 1 1 Negative Genetic, Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 2 1 1 Negative Genetic, Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 1 Negative Genetic, Negative Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 2 1 1 Negative Genetic, Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Positive Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Positive Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
MAK16 YAL025C Essential nuclear protein genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Negative Genetic
RPL10 YLR075W Ribosomal 60S subunit protein L10 genetic 1 1 1 Negative Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
PEX7 YDR142C Peroxisomal signal receptor for peroxisomal matrix proteins physical 1 1 1 Affinity Capture-MS
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 1 1 1 Positive Genetic
RAX2 YLR084C Protein required for the maintenance of bud site selection genetic 1 1 1 Negative Genetic
POP1 YNL221C Subunit of RNase MRP, nuclear RNase P and telomerase complexes genetic 1 1 1 Positive Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
PWP2 YCR057C Conserved 90S pre-ribosomal component genetic 1 1 1 Positive Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Positive Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b genetic 1 1 1 Positive Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 1 1 1 Affinity Capture-MS
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p physical 1 1 1 Affinity Capture-MS
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 Affinity Capture-MS
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) physical 1 1 1 Affinity Capture-MS
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
VPS45 YGL095C Protein of the Sec1p/Munc-18 family physical 1 1 1 Affinity Capture-MS
TCD2 YKL027W tRNA threonylcarbamoyladenosine dehydratase physical 1 1 1 Affinity Capture-MS
RRI2 YOL117W Subunit of the COP9 signalosome (CSN) complex physical 1 1 1 Affinity Capture-MS
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 1 1 1 Affinity Capture-Western
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 1 1 1 Affinity Capture-RNA
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Negative Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 1 1 1 Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Negative Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Negative Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 1 1 1 Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Positive Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Positive Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
SPT14 YPL175W UDP-glycosyltransferase subunit of the GPI-GnT complex genetic 1 1 1 Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Positive Genetic
RSA4 YCR072C Ribosomal large subunit (60S) assembly factor genetic 1 1 1 Positive Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Positive Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Positive Genetic
TAF10 YDR167W Subunit (145 kDa) of TFIID and SAGA complexes genetic 1 1 1 Positive Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Positive Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Positive Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Positive Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Positive Genetic
RRN9 YMR270C Protein involved in promoting high level transcription of rDNA genetic 1 1 1 Positive Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Positive Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Positive Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Positive Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 1 1 1 Positive Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Positive Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Positive Genetic
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 1 1 1 Positive Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
YHL042W YHL042W Endoplasmic reticulum protein genetic 1 1 1 Positive Genetic
YKL033W-A YKL033W-A Protein of unknown function genetic 1 1 1 Positive Genetic
SDH1 YKL148C Flavoprotein subunit of succinate dehydrogenase genetic 1 1 1 Positive Genetic
VPS501 YKR078W Vacuolar SNX-BAR protein genetic 1 1 1 Positive Genetic
SPO75 YLL005C Meiosis-specific protein of unknown function genetic 1 1 1 Positive Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
TFS1 YLR178C Inhibitor of carboxypeptidase Y (Prc1p), and Ras GAP (Ira2p) genetic 1 1 1 Positive Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
YOR289W YOR289W Putative protein of unknown function genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
YPL225W YPL225W Protein of unknown function genetic 1 1 1 Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Positive Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Positive Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SNC2 YOR327C Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Positive Genetic
SRB6 YBR253W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SAD1 YFR005C Conserved zinc-finger domain protein involved in pre-mRNA splicing genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
RPO31 YOR116C RNA polymerase III largest subunit C160 genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Negative Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
TIF34 YMR146C eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Negative Genetic
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
SPC29 YPL124W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
YCR016W YCR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUT1 YGL162W Zn(II)2Cys6 family transcription factor genetic 1 1 1 Negative Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
TRP3 YKL211C Indole-3-glycerol-phosphate synthase genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Negative Genetic
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Negative Genetic
YAR1 YPL239W Nucleocytoplasmic shuttling assembly chaperone genetic 1 1 1 Negative Genetic
YPR089W YPR089W Protein of unknown function genetic 1 1 1 Negative Genetic
SCS22 YBL091C-A Protein involved in regulation of phospholipid metabolism genetic 1 1 1 Negative Genetic
VID24 YBR105C GID Complex regulatory subunit genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TRP2 YER090W Anthranilate synthase genetic 1 1 1 Negative Genetic
UBP5 YER144C Putative ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SBE22 YHR103W Protein involved in bud growth genetic 1 1 1 Negative Genetic
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Negative Genetic
YJU3 YKL094W Monoglyceride lipase (MGL) that hydrolyzes fatty acid ethyl esters genetic 1 1 1 Negative Genetic
STE3 YKL178C Receptor for a factor pheromone genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
TRK2 YKR050W Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Negative Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
SPE4 YLR146C Spermine synthase genetic 1 1 1 Negative Genetic
YLR287C YLR287C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLR297W YLR297W Protein of unknown function genetic 1 1 1 Negative Genetic
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Negative Genetic
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SCW10 YMR305C Cell wall protein with similarity to glucanases genetic 1 1 1 Negative Genetic
SPO1 YNL012W Meiosis-specific prospore protein genetic 1 1 1 Negative Genetic
YNL146W YNL146W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Negative Genetic
YOR238W YOR238W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism genetic 1 1 1 Negative Genetic
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 1 1 1 Negative Genetic
SPP1 YPL138C Subunit of COMPASS (Set1C) genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
YPL162C YPL162C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YAR066W YAR066W Putative GPI protein genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
YBR196C-A YBR196C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SSH1 YBR283C Subunit of the Ssh1 translocon complex genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YER053C-A YER053C-A Protein of unknown function genetic 1 1 1 Negative Genetic
VHR2 YER064C Non-essential nuclear protein genetic 1 1 1 Negative Genetic
YFR006W YFR006W Putative X-Pro aminopeptidase genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Negative Genetic
RPS23A YGR118W Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Negative Genetic
SLH1 YGR271W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
URM1 YIL008W Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs genetic 1 1 1 Negative Genetic
RPS24B YIL069C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
YJR142W YJR142W 8-oxo-dGTP diphosphatase of the Nudix hydrolase family genetic 1 1 1 Negative Genetic
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SEG2 YKL105C Eisosome component genetic 1 1 1 Negative Genetic
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
TRM2 YKR056W tRNA methyltransferase genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
YLR156W YLR156W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YLR264C-A YLR264C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
TRM9 YML014W tRNA methyltransferase genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
YMR001C-A YMR001C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSF1 YMR030W Protein required for respiratory growth genetic 1 1 1 Negative Genetic
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
SNF12 YNR023W 73 kDa subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Negative Genetic
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SMA1 YPL027W Protein of unknown function involved in prospore membrane assembly genetic 1 1 1 Negative Genetic
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 1 1 1 Positive Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Positive Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 1 1 1 Positive Genetic
YML108W YML108W Protein of unknown function genetic 1 1 1 Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 1 1 1 Negative Genetic
SEY1 YOR165W Dynamin-like GTPase that mediates homotypic ER fusion genetic 1 1 1 Negative Genetic
SER1 YOR184W 3-phosphoserine aminotransferase genetic 1 1 1 Positive Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) genetic 1 1 1 Positive Genetic
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Positive Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 1 1 1 Reconstituted Complex
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 genetic 1 1 1 Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
RIX1 YHR197W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Positive Genetic
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Positive Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Positive Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Positive Genetic
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
HAT2 YEL056W Subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HHF2 YNL030W Histone H4 genetic 1 1 1 Negative Genetic
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 1 1 1 Positive Genetic
ECM29 YHL030W Scaffold protein genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM2 YBL026W Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-MS
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription physical 1 1 1 Affinity Capture-MS
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
ATG26 YLR189C UDP-glucose:sterol glucosyltransferase genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL39 YML009C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Negative Genetic
INO80 YGL150C Nucleosome spacing factor genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 Affinity Capture-MS
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Positive Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
BLM10 YFL007W Proteasome activator genetic 1 1 1 Negative Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Positive Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Positive Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Positive Genetic
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Negative Genetic
REF2 YDR195W RNA-binding protein genetic 1 1 1 Negative Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
FYV8 YGR196C Protein of unknown function genetic 1 1 1 Positive Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Positive Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 1 1 1 Negative Genetic
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Positive Genetic
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA physical 1 1 1 Affinity Capture-MS
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 1 1 1 Negative Genetic
KTR5 YNL029C Putative mannosyltransferase involved in protein glycosylation genetic 1 1 1 Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 1 1 1 Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity physical 1 1 1 Affinity Capture-MS
FUN19 YAL034C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Negative Genetic
FES1 YBR101C Hsp70 (Ssa1p) nucleotide exchange factor genetic 1 1 1 Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 1 1 1 Affinity Capture-MS
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 1 1 1 Negative Genetic
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
AXL1 YPR122W Haploid specific endoprotease of a-factor mating pheromone genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
RHO1 YPR165W GTP-binding protein of the rho subfamily of Ras-like proteins genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
COS111 YBR203W Protein required for antifungal drug ciclopirox olamine resistance genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Positive Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 1 1 1 Negative Genetic
BUD32 YGR262C Protein kinase physical 1 1 1 Affinity Capture-MS
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 1 1 1 Positive Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation physical 1 1 1 Affinity Capture-MS
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) genetic 1 1 1 Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Positive Genetic
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Negative Genetic
INA1 YLR413W Protein of unknown function genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Negative Genetic
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
CAF4 YKR036C WD40 repeat-containing protein associated with the CCR4-NOT complex genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Positive Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Affinity Capture-MS
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase genetic 1 1 1 Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 1 1 1 Negative Genetic
PTP2 YOR208W Phosphotyrosine-specific phosphatase genetic 1 1 1 Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
MFB1 YDR219C Mitochondria-associated F-box protein genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Negative Genetic
DEF1 YKL054C RNAPII degradation factor physical 1 1 1 Affinity Capture-MS
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
ALD5 YER073W Mitochondrial aldehyde dehydrogenase genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
GDH2 YDL215C NAD(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Positive Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Phenotypic Suppression
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DDI1 YER143W Aspartic-type endopeptidase genetic 1 1 1 Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Negative Genetic
NAS2 YIL007C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 1 1 1 Affinity Capture-Western
FMN1 YDR236C Riboflavin kinase, produces riboflavin monophosphate (FMN) genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
LPP1 YDR503C Lipid phosphate phosphatase genetic 1 1 1 Positive Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 1 1 1 Two-hybrid
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Positive Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
RPL23B YER117W Ribosomal 60S subunit protein L23B genetic 1 1 1 Negative Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 1 1 1 Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 1 1 1 Affinity Capture-RNA
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
EPS1 YIL005W ER protein with chaperone and co-chaperone activity genetic 1 1 1 Negative Genetic
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Positive Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 1 1 1 Negative Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Positive Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 1 1 1 Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 1 1 1 Negative Genetic
PAM18 YLR008C Subunit of the import motor (PAM complex) genetic 1 1 1 Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Negative Genetic
FIG4 YNL325C Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase genetic 1 1 1 Negative Genetic
KTI11 YBL071W-A Zn-ribbon protein that co-purifies with Dph1 and Dph2 genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ERV46 YAL042W Protein localized to COPII-coated vesicles physical 1 1 1 Affinity Capture-MS
GAP1 YKR039W General amino acid permease genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
GNT1 YOR320C N-acetylglucosaminyltransferase genetic 1 1 1 Positive Genetic
GIC2 YDR309C Rho-family GTPase interacting protein and Cdc42p effector genetic 1 1 1 Negative Genetic
HRI1 YLR301W Protein of unknown function that interacts with Sec72p and Hrr25p genetic 1 1 1 Negative Genetic
PEX30 YLR324W ER-resident protein involved in peroxisomal biogenesis genetic 1 1 1 Negative Genetic
PEX27 YOR193W Peripheral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Positive Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Negative Genetic
ERV29 YGR284C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Negative Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Positive Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
HUB1 YNR032C-A Ubiquitin-like protein modifier genetic 1 1 1 Positive Genetic
RDS3 YPR094W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Positive Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 1 1 1 Affinity Capture-MS
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Negative Genetic
MCR1 YKL150W Mitochondrial NADH-cytochrome b5 reductase genetic 1 1 1 Positive Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
RPL14B YHL001W Ribosomal 60S subunit protein L14B genetic 1 1 1 Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Positive Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth genetic 1 1 1 Positive Genetic
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Negative Genetic
HOT13 YKL084W Zinc-binding mitochondrial intermembrane space (IMS) protein genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Positive Genetic
EMC6 YLL014W Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
KIP2 YPL155C Kinesin-related motor protein involved in mitotic spindle positioning genetic 1 1 1 Positive Genetic
ROY1 YMR258C GTPase inhibitor with similarity to F-box proteins genetic 1 1 1 Negative Genetic
EXG2 YDR261C Exo-1,3-beta-glucanase genetic 1 1 1 Negative Genetic
FRA1 YLL029W Protein involved in negative regulation of iron regulon transcription genetic 1 1 1 Positive Genetic
MEI5 YPL121C Meiosis-specific protein involved in meiotic recombination genetic 1 1 1 Positive Genetic
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p genetic 1 1 1 Negative Genetic
HEH2 YDR458C Inner nuclear membrane (INM) protein genetic 1 1 1 Negative Genetic
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
PAM17 YKR065C Constituent of the TIM23 complex genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
PEX1 YKL197C AAA-peroxin genetic 1 1 1 Positive Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Positive Genetic
PHO11 YAR071W One of three repressible acid phosphatases genetic 1 1 1 Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 1 1 1 Negative Genetic
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Positive Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Positive Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
COQ11 YLR290C Putative oxidoreductase, subunit of Coenzyme Q biosynthetic complexes genetic 1 1 1 Positive Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Negative Genetic
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase genetic 1 1 1 Negative Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase genetic 1 1 1 Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 1 1 1 Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Negative Genetic
COA4 YLR218C Twin Cx(9)C protein involved in cytochrome c oxidase organization genetic 1 1 1 Positive Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 1 1 1 Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Negative Genetic
CUZ1 YNL155W Protein with a role in the ubiquitin-proteasome pathway genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
MSB1 YOR188W Protein of unknown function genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Positive Genetic
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Positive Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 1 1 1 Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
RPL33B YOR234C Ribosomal 60S subunit protein L33B genetic 1 1 1 Negative Genetic
RPL6A YML073C Ribosomal 60S subunit protein L6A genetic 1 1 1 Negative Genetic
DPH5 YLR172C Methyltransferase required for synthesis of diphthamide genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Negative Genetic
RPL34A YER056C-A Ribosomal 60S subunit protein L34A genetic 1 1 1 Negative Genetic
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
FRE8 YLR047C Protein with sequence similarity to iron/copper reductases genetic 1 1 1 Positive Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Negative Genetic
MLF3 YNL074C Serine-rich protein of unknown function genetic 1 1 1 Negative Genetic
PSP1 YDR505C Asn and gln rich protein of unknown function genetic 1 1 1 Negative Genetic
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Positive Genetic
MRX3 YBL095W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Negative Genetic
QNS1 YHR074W Glutamine-dependent NAD(+) synthetase genetic 1 1 1 Negative Genetic
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 1 1 1 Negative Genetic
CHS2 YBR038W Chitin synthase II genetic 1 1 1 Negative Genetic
AST2 YER101C Lipid raft associated protein genetic 1 1 1 Negative Genetic
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Positive Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NOP10 YHR072W-A Subunit of box H/ACA snoRNP complex genetic 1 1 1 Negative Genetic
PRY2 YKR013W Sterol binding protein involved in the export of acetylated sterols genetic 1 1 1 Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Positive Genetic
ARO10 YDR380W Phenylpyruvate decarboxylase genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Negative Genetic
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Positive Genetic
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 1 1 1 Positive Genetic
FRE5 YOR384W Putative ferric reductase with similarity to Fre2p genetic 1 1 1 Negative Genetic
ATG41 YPL250C Protein of unknown function genetic 1 1 1 Negative Genetic
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Negative Genetic
PIR3 YKL163W O-glycosylated covalently-bound cell wall protein genetic 1 1 1 Negative Genetic
MET5 YJR137C Sulfite reductase beta subunit genetic 1 1 1 Positive Genetic
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Proximity Label-MS
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
IRC18 YJL037W Protein involved in outer spore wall assembly genetic 1 1 1 Negative Genetic
HEL1 YKR017C RING finger ubiquitin ligase (E3) genetic 1 1 1 Negative Genetic
LCL2 YLR104W Putative protein of unknown function genetic 1 1 1 Negative Genetic
CHM7 YJL049W Yeast homolog of human CHMP7, localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
BER1 YLR412W Protein involved in microtubule-related processes genetic 1 1 1 Positive Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
DGK1 YOR311C Diacylglycerol kinase genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 1 1 1 Negative Genetic
NAR1 YNL240C Subunit of the cytosolic iron-sulfur (FeS) protein assembly machinery genetic 1 1 1 Positive Genetic
HTC1 YPL067C Putative protein of unknown function genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 1 1 1 Negative Genetic
HEM4 YOR278W Uroporphyrinogen III synthase genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Positive Genetic
PET20 YPL159C Mitochondrial protein genetic 1 1 1 Negative Genetic
DML1 YMR211W Essential protein involved in mtDNA inheritance genetic 1 1 1 Negative Genetic
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 1 1 1 Negative Genetic
FAT3 YKL187C Protein required for fatty acid uptake genetic 1 1 1 Negative Genetic
MIN3 YMR182W-A Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic