Standard name Systematic name Name description Description
RAS2 YNL098C GTP-binding protein GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; activated by increased levels of glycolysis intermediate fructose-1,6-bisphosphate; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication
Visualize the interactome of RAS2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.989 0.991 0.974

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 19800

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAS2 3 1 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 19 6 17 Synthetic Lethality, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Rescue, Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality
SCH9 YHR205W AGC family protein kinase genetic 10 4 10 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor physical 10 4 9 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Biochemical Activity, Two-hybrid, Reconstituted Complex, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 9 3 8 Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue, Dosage Rescue, Phenotypic Suppression
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 8 3 8 Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue, Dosage Rescue, Synthetic Rescue
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 7 4 7 Dosage Rescue, Phenotypic Suppression, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement
CYR1 YJL005W Adenylate cyclase genetic 7 3 6 Dosage Rescue, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Synthetic Rescue, Negative Genetic
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 6 4 6 Dosage Rescue, Dosage Rescue, Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Synthetic Rescue
IRA2 YOL081W GTPase-activating protein genetic 6 3 6 Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 6 2 6 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
LTE1 YAL024C Protein similar to GDP/GTP exchange factors physical 6 4 4 Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS
SYS1 YJL004C Integral membrane protein of the Golgi genetic 6 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TPK2 YPL203W cAMP-dependent protein kinase catalytic subunit genetic 5 2 5 Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue, Dosage Rescue
SHR5 YOL110W Palmitoyltransferase subunit genetic 4 4 4 Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
MSN4 YKL062W Stress-responsive transcriptional activator genetic 4 4 4 Phenotypic Suppression, Synthetic Rescue, Dosage Growth Defect, Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 4 3 4 Dosage Rescue, Synthetic Rescue, Negative Genetic, Negative Genetic
TPK3 YKL166C cAMP-dependent protein kinase catalytic subunit genetic 4 2 4 Dosage Rescue, Phenotypic Suppression, Dosage Rescue, Dosage Rescue
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 2 4 Positive Genetic, Negative Genetic, Positive Genetic, Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 4 2 4 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 4 1 4 Dosage Rescue, Dosage Rescue, Dosage Rescue, Dosage Rescue
MTL1 YGR023W Putative plasma membrane sensor genetic 4 3 3 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression
KIN1 YDR122W S/T protein kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 3 3 Synthetic Growth Defect, Positive Genetic, Phenotypic Suppression
RSR1 YGR152C Ras-type GTPase genetic 3 3 3 Dosage Rescue, Synthetic Lethality, Synthetic Rescue
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 3 3 3 Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression
MSN2 YMR037C Stress-responsive transcriptional activator genetic 3 3 3 Phenotypic Suppression, Synthetic Rescue, Dosage Growth Defect
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
ELM1 YKL048C Serine/threonine protein kinase genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade genetic 3 2 3 Dosage Rescue, Phenotypic Suppression, Phenotypic Suppression
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 3 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 3 2 3 Synthetic Rescue, Negative Genetic, Negative Genetic
MET3 YJR010W ATP sulfurylase genetic 3 2 3 Synthetic Rescue, Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 1 3 Dosage Rescue, Dosage Rescue, Dosage Rescue
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 3 3 2 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
DOC1 YGL240W Processivity factor genetic 3 3 2 Dosage Lethality, Synthetic Lethality, Synthetic Rescue
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 3 2 2 Negative Genetic, Negative Genetic, Phenotypic Suppression
DFG16 YOR030W Probable multiple transmembrane protein genetic 3 2 2 Phenotypic Suppression, Negative Genetic, Negative Genetic
ACH1 YBL015W Protein with CoA transferase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MAE1 YKL029C Mitochondrial malic enzyme genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DOG1 YHR044C 2-deoxyglucose-6-phosphate phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YDR210W YDR210W Predicted tail-anchored plasma membrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RIM9 YMR063W Plasma membrane protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VTC4 YJL012C Vacuolar membrane polyphosphate polymerase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ATG8 YBL078C Ub-like protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway physical 3 3 1 Two-hybrid, Affinity Capture-Western, Affinity Capture-MS
CYR1 YJL005W Adenylate cyclase physical 2 2 2 Affinity Capture-Western, Biochemical Activity
HSP82 YPL240C Hsp90 chaperone genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
IRA2 YOL081W GTPase-activating protein physical 2 2 2 Biochemical Activity, Reconstituted Complex
IRA1 YBR140C GTPase-activating protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
IRA1 YBR140C GTPase-activating protein genetic 2 2 2 Dosage Lethality, Synthetic Rescue
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 2 2 Dosage Lethality, Synthetic Lethality
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Dosage Lethality, Synthetic Lethality
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 2 2 2 Dosage Rescue, Synthetic Rescue
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 2 2 2 Dosage Rescue, Phenotypic Suppression
TPM1 YNL079C Major isoform of tropomyosin genetic 2 2 2 Synthetic Lethality, Phenotypic Suppression
YAK1 YJL141C Serine-threonine protein kinase genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
RCE1 YMR274C Type II CAAX prenyl protease genetic 2 2 2 Phenotypic Suppression, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 2 2 Positive Genetic, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 2 2 Positive Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 2 2 Phenotypic Suppression, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
BUD8 YLR353W Protein involved in bud-site selection genetic 2 2 2 Phenotypic Suppression, Negative Genetic
ERF2 YLR246W Subunit of a palmitoyltransferase physical 2 2 2 Co-localization, Biochemical Activity
PDE1 YGL248W Low-affinity cyclic AMP phosphodiesterase genetic 2 2 2 Dosage Rescue, Synthetic Rescue
COX16 YJL003W Mitochondrial inner membrane protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 2 1 2 Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 1 2 Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
GET1 YGL020C Subunit of the GET complex genetic 2 1 2 Negative Genetic, Negative Genetic
KSP1 YHR082C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
RPI1 YIL119C Transcription factor, allelic differences between S288C and Sigma1278b genetic 2 1 2 Dosage Rescue, Dosage Rescue
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 2 Negative Genetic, Negative Genetic
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SHE9 YDR393W Protein required for normal mitochondrial morphology genetic 2 1 2 Negative Genetic, Negative Genetic
SPO16 YHR153C Meiosis-specific protein involved in synaptonemal complex assembly genetic 2 1 2 Negative Genetic, Negative Genetic
TMA22 YJR014W Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YJR098C YJR098C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 1 2 Negative Genetic, Negative Genetic
VPS28 YPL065W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 2 Negative Genetic, Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 2 1 2 Negative Genetic, Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 2 1 2 Negative Genetic, Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 2 1 2 Positive Genetic, Positive Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 2 1 2 Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 2 2 1 Two-hybrid, Affinity Capture-Western
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 1 Synthetic Lethality, Synthetic Rescue
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 2 1 Dosage Rescue, Synthetic Rescue
YCF1 YDR135C Vacuolar glutathione S-conjugate transporter physical 2 2 1 Affinity Capture-Western, PCA
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
TSA1 YML028W Thioredoxin peroxidase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 2 2 1 Dosage Rescue, Phenotypic Enhancement
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 1 Dosage Rescue, Synthetic Rescue
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 2 2 1 Synthetic Rescue, Synthetic Growth Defect
CBF2 YGR140W Essential kinetochore protein genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
MID2 YLR332W O-glycosylated plasma membrane protein physical 2 2 1 Two-hybrid, Affinity Capture-MS
ERF2 YLR246W Subunit of a palmitoyltransferase genetic 2 2 1 Synthetic Rescue, Synthetic Lethality
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
APL1 YJR005W Beta-adaptin genetic 2 1 1 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter physical 2 1 1 PCA, PCA
RHB1 YCR027C Putative Rheb-related GTPase genetic 2 1 1 Negative Genetic, Negative Genetic
TES1 YJR019C Peroxisomal acyl-CoA thioesterase genetic 2 1 1 Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 2 1 1 Negative Genetic, Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 2 1 1 Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 1 1 Negative Genetic, Negative Genetic
IOC4 YMR044W Member of a complex (Isw1b) with Isw1p and Ioc2p genetic 2 1 1 Positive Genetic, Positive Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 2 1 1 Negative Genetic, Negative Genetic
ERS1 YCR075C Protein involved in cystine transport genetic 2 1 1 Negative Genetic, Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MSN2 YMR037C Stress-responsive transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT7 YBR081C Subunit of the SAGA transcriptional regulatory complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SKN7 YHR206W Nuclear response regulator and transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
AIM25 YJR100C Mitochondria protein of unknown function genetic 1 1 1 Phenotypic Enhancement
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
AXL2 YIL140W Integral plasma membrane protein genetic 1 1 1 Positive Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Dosage Rescue
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
PRP3 YDR473C Splicing factor genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
PTA1 YAL043C Subunit of holo-CPF genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Phenotypic Suppression
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I genetic 1 1 1 Negative Genetic
APL2 YKL135C Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex genetic 1 1 1 Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Rescue
BNI1 YNL271C Formin genetic 1 1 1 Phenotypic Suppression
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Phenotypic Suppression
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 1 1 1 Negative Genetic
MPP10 YJR002W Component of the SSU processome and 90S preribosome genetic 1 1 1 Negative Genetic
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Phenotypic Suppression
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Rescue
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Positive Genetic
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
MRP1 YDR347W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Proximity Label-MS
MRPL28 YDR462W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPS28 YDR337W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Phenotypic Suppression
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 PCA
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Positive Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis genetic 1 1 1 Negative Genetic
RAM1 YDL090C Beta subunit of the CAAX farnesyltransferase (FTase) genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
BNA3 YJL060W Kynurenine aminotransferase genetic 1 1 1 Negative Genetic
GPH1 YPR160W Glycogen phosphorylase required for the mobilization of glycogen genetic 1 1 1 Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Negative Genetic
ACO1 YLR304C Aconitase genetic 1 1 1 Positive Genetic
MDH1 YKL085W Mitochondrial malate dehydrogenase genetic 1 1 1 Negative Genetic
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Dosage Rescue
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Positive Genetic
ATG17 YLR423C Scaffold protein responsible for phagophore assembly site organization genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Dosage Rescue
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
PGM2 YMR105C Phosphoglucomutase genetic 1 1 1 Phenotypic Enhancement
CBK1 YNL161W Serine/threonine protein kinase of the the RAM signaling network genetic 1 1 1 Synthetic Growth Defect
ACS2 YLR153C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Negative Genetic
MRS6 YOR370C Rab escort protein genetic 1 1 1 Dosage Rescue
COS111 YBR203W Protein required for antifungal drug ciclopirox olamine resistance genetic 1 1 1 Negative Genetic
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Positive Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Synthetic Growth Defect
HYM1 YKL189W Component of the RAM signaling network genetic 1 1 1 Synthetic Growth Defect
CDC15 YAR019C Hippo-like kinase of the Mitotic Exit Network genetic 1 1 1 Dosage Rescue
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Phenotypic Suppression
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 1 1 1 Synthetic Growth Defect
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 1 1 1 Negative Genetic
TSR1 YDL060W Protein required for processing of 20S pre-rRNA in the cytoplasm physical 1 1 1 Affinity Capture-MS
RAS2 YNL098C GTP-binding protein physical 1 1 1 Reconstituted Complex
STE14 YDR410C Farnesyl cysteine-carboxyl methyltransferase physical 1 1 1 Reconstituted Complex
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 PCA
YPL088W YPL088W Putative aryl alcohol dehydrogenase physical 1 1 1 Two-hybrid
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit physical 1 1 1 Biochemical Activity
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
ROD1 YOR018W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Reconstituted Complex
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Reconstituted Complex
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) physical 1 1 1 Two-hybrid
TIM23 YNR017W Essential component of the TIM23 complex physical 1 1 1 Affinity Capture-MS
SRB4 YER022W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Lethality
SNC1 YAL030W Vesicle membrane receptor protein (v-SNARE) genetic 1 1 1 Dosage Rescue
SPO12 YHR152W Nucleolar protein of unknown function genetic 1 1 1 Dosage Rescue
STE11 YLR362W Signal transducing MEK kinase genetic 1 1 1 Dosage Rescue
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Dosage Rescue
UBI4 YLL039C Ubiquitin genetic 1 1 1 Dosage Rescue
TAO3 YIL129C Component of the RAM signaling network genetic 1 1 1 Synthetic Growth Defect
RGR1 YLR071C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Synthetic Lethality
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Synthetic Rescue
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Synthetic Rescue
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Phenotypic Suppression
RPS0A YGR214W Ribosomal 40S subunit protein S0A genetic 1 1 1 Phenotypic Suppression
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Phenotypic Suppression
SPA2 YLL021W Component of the polarisome genetic 1 1 1 Phenotypic Suppression
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Rescue
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Rescue
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Dosage Rescue
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes genetic 1 1 1 Synthetic Growth Defect
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Synthetic Rescue
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Dosage Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
TRF5 YNL299W Non-canonical poly(A) polymerase genetic 1 1 1 Negative Genetic
SAC3 YDR159W mRNA export factor genetic 1 1 1 Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Positive Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Phenotypic Suppression
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Growth Defect
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Lethality
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 1 1 1 Positive Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Positive Genetic
YMR1 YJR110W Phosphatidylinositol 3-phosphate (PI3P) phosphatase genetic 1 1 1 Positive Genetic
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Positive Genetic
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Positive Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Phenotypic Suppression
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 1 1 1 Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 1 1 1 Negative Genetic
YGR079W YGR079W Protein of unknown function genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SUT2 YPR009W Zn2Cys6 family transcription factor genetic 1 1 1 Dosage Rescue
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Synthetic Growth Defect
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Phenotypic Enhancement
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Positive Genetic
WSC2 YNL283C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Phenotypic Suppression
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Phenotypic Suppression
WSC4 YHL028W Endoplasmic reticulum (ER) membrane protein genetic 1 1 1 Phenotypic Suppression
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Phenotypic Enhancement
SKS1 YPL026C Putative serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
UGP1 YKL035W UDP-glucose pyrophosphorylase (UGPase) genetic 1 1 1 Phenotypic Suppression
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Synthetic Rescue
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export genetic 1 1 1 Positive Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
SSD1 YDR293C Translational repressor genetic 1 1 1 Positive Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Positive Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Positive Genetic
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Positive Genetic
YGL114W YGL114W Putative protein of unknown function genetic 1 1 1 Positive Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
RBG2 YGR173W Protein with a role in translation genetic 1 1 1 Positive Genetic
RSM27 YGR215W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
YOR008C-A YOR008C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Positive Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
URB2 YJR041C Protein required for normal metabolism of the rRNA primary transcript genetic 1 1 1 Negative Genetic
TFA1 YKL028W TFIIE large subunit genetic 1 1 1 Negative Genetic
UTP13 YLR222C Nucleolar protein genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
SOG2 YOR353C Key component of the RAM signaling network genetic 1 1 1 Negative Genetic
YCL001W-B YCL001W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
YHP1 YDR451C Homeobox transcriptional repressor genetic 1 1 1 Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Negative Genetic
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 1 1 1 Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TDH1 YJL052W Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 1 genetic 1 1 1 Negative Genetic
YJL070C YJL070C Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Negative Genetic
SNA3 YJL151C Protein involved in efficient MVB sorting of proteins to the vacuole genetic 1 1 1 Negative Genetic
YJR015W YJR015W Putative protein of unknown function genetic 1 1 1 Negative Genetic
THI7 YLR237W Plasma membrane transporter responsible for the uptake of thiamine genetic 1 1 1 Negative Genetic
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SAM2 YDR502C S-adenosylmethionine synthetase genetic 1 1 1 Negative Genetic
YFL012W YFL012W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RIE1 YGR250C RNA binding protein and negative regulator of START genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Negative Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Negative Genetic
YML053C YML053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SHH3 YMR118C Putative mitochondrial inner membrane protein of unknown function genetic 1 1 1 Negative Genetic
SAM3 YPL274W High-affinity S-adenosylmethionine permease genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Negative Genetic
WHI5 YOR083W Repressor of G1 transcription genetic 1 1 1 Negative Genetic
TIM18 YOR297C Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 1 1 1 Phenotypic Suppression
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 1 1 1 Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Rescue
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Phenotypic Suppression
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Negative Genetic
KIC1 YHR102W Protein kinase of the PAK/Ste20 family, required for cell integrity genetic 1 1 1 Synthetic Growth Defect
PGM1 YKL127W Phosphoglucomutase, minor isoform genetic 1 1 1 Phenotypic Suppression
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Dosage Lethality
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
AHC1 YOR023C Subunit of the Ada histone acetyltransferase complex genetic 1 1 1 Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Positive Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Synthetic Rescue
MIC19 YFR011C Component of the MICOS complex genetic 1 1 1 Negative Genetic
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p genetic 1 1 1 Negative Genetic
ADE6 YGR061C Formylglycinamidine-ribonucleotide (FGAM)-synthetase genetic 1 1 1 Synthetic Rescue
MET16 YPR167C 3'-phosphoadenylsulfate reductase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 1 1 1 Positive Genetic
LAC1 YKL008C Ceramide synthase component genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Positive Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Negative Genetic
MSB2 YGR014W Mucin family member involved in various signaling pathways genetic 1 1 1 Phenotypic Suppression
PEX18 YHR160C Peroxin genetic 1 1 1 Negative Genetic
PEX14 YGL153W Central component of the peroxisomal importomer complex genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Negative Genetic
MDE1 YJR024C 5'-methylthioribulose-1-phosphate dehydratase genetic 1 1 1 Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 1 1 1 Negative Genetic
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
GRC3 YLL035W Polynucleotide kinase present on rDNA genetic 1 1 1 Positive Genetic
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Rescue
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Negative Genetic
BUD5 YCR038C GTP/GDP exchange factor for Rsr1p (Bud1p) genetic 1 1 1 Dosage Rescue
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Positive Genetic
KAR9 YPL269W Spindle positioning factor genetic 1 1 1 Synthetic Growth Defect
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Negative Genetic
PEA2 YER149C Coiled-coil 12S polarisome subunit genetic 1 1 1 Phenotypic Suppression
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Dosage Rescue
ERV46 YAL042W Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
PDR17 YNL264C Phosphatidylinositol transfer protein (PITP) genetic 1 1 1 Synthetic Lethality
EMC1 YCL045C Member of conserved endoplasmic reticulum membrane complex genetic 1 1 1 Negative Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing genetic 1 1 1 Negative Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Phenotypic Suppression
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase physical 1 1 1 Affinity Capture-MS
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Synthetic Growth Defect
PDR5 YOR153W Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 PCA
DPC29 YGR021W Putative mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Rescue
DFG5 YMR238W Putative mannosidase genetic 1 1 1 Phenotypic Suppression
ACF2 YLR144C Intracellular beta-1,3-endoglucanase genetic 1 1 1 Negative Genetic
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes genetic 1 1 1 Dosage Rescue
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Phenotypic Suppression
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Synthetic Rescue
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Positive Genetic
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Rescue
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 1 1 1 Negative Genetic
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
HBT1 YDL223C Shmoo tip protein, substrate of Hub1p ubiquitin-like protein genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
GPB1 YOR371C Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Phenotypic Suppression
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI physical 1 1 1 Affinity Capture-Western
LYS20 YDL182W Homocitrate synthase isozyme and functions in DNA repair genetic 1 1 1 Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Negative Genetic
MBA1 YBR185C Membrane-associated mitochondrial ribosome receptor genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 1 1 1 Negative Genetic
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 1 1 1 Negative Genetic
HIS6 YIL020C Enzyme that catalyzes the fourth step in the histidine pathway genetic 1 1 1 Synthetic Rescue
CGI121 YML036W Component of the EKC/KEOPS complex genetic 1 1 1 Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
MRPL32 YCR003W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
COA3 YJL062W-A Mitochondrial protein required for cytochrome c oxidase assembly genetic 1 1 1 Positive Genetic
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Reconstituted Complex
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Negative Genetic
KIN82 YCR091W Putative serine/threonine protein kinase genetic 1 1 1 Negative Genetic
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase genetic 1 1 1 Phenotypic Suppression
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Positive Genetic
PTP1 YDL230W Phosphotyrosine-specific protein phosphatase genetic 1 1 1 Positive Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
GIS1 YDR096W Histone demethylase and transcription factor genetic 1 1 1 Phenotypic Suppression
AST2 YER101C Lipid raft associated protein genetic 1 1 1 Positive Genetic
NPR1 YNL183C Protein kinase genetic 1 1 1 Synthetic Rescue
INO1 YJL153C Inositol-3-phosphate synthase genetic 1 1 1 Synthetic Rescue
COX23 YHR116W Protein that functions in mitochondrial copper homeostasis genetic 1 1 1 Positive Genetic
MEP2 YNL142W Ammonium permease involved in regulation of pseudohyphal growth genetic 1 1 1 Phenotypic Suppression
PPS1 YBR276C Protein phosphatase genetic 1 1 1 Dosage Rescue
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
MRX12 YJR003C Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
MTC2 YKL098W Protein of unknown function genetic 1 1 1 Negative Genetic
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Phenotypic Suppression
EMA19 YLR050C Integral ER membrane protein involved in protein sorting genetic 1 1 1 Negative Genetic
ALK1 YGL021W Atypical protein kinase genetic 1 1 1 Phenotypic Suppression
ELO1 YJL196C Elongase I, medium-chain acyl elongase genetic 1 1 1 Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Negative Genetic
MIC60 YKR016W Component of the MICOS complex genetic 1 1 1 Negative Genetic
APA2 YDR530C Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase II genetic 1 1 1 Negative Genetic
MPC1 YGL080W Highly conserved subunit of mitochondrial pyruvate carrier (MPC) genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
DSC2 YOL073C Multi-transmembrane subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Positive Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Phenotypic Suppression
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 1 1 1 Dosage Growth Defect
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
ALK2 YBL009W Atypical protein kinase genetic 1 1 1 Phenotypic Suppression
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
CBT1 YKL208W Protein involved in 5' RNA end processing genetic 1 1 1 Positive Genetic
MTQ1 YNL063W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Phenotypic Suppression
CTM1 YHR109W Cytochrome c lysine methyltransferase genetic 1 1 1 Positive Genetic
PCP1 YGR101W Mitochondrial serine protease genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Negative Genetic