| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
physical |
15 |
3 |
9 |
Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity |
| HSL7 |
YBR133C |
Protein arginine N-methyltransferase |
physical |
13 |
4 |
6 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-MS, Reconstituted Complex |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
genetic |
9 |
4 |
7 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue |
| CDC5 |
YMR001C |
Polo-like kinase required for mitotic exit |
physical |
9 |
4 |
6 |
Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Co-localization, Biochemical Activity, Two-hybrid, Two-hybrid |
| CDH1 |
YGL003C |
Activator of anaphase-promoting complex/cyclosome (APC/C) |
genetic |
7 |
4 |
7 |
Phenotypic Enhancement, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
physical |
6 |
4 |
6 |
Affinity Capture-MS, Two-hybrid, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Biochemical Activity |
| ELM1 |
YKL048C |
Serine/threonine protein kinase |
genetic |
6 |
3 |
6 |
Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Suppression, Negative Genetic, Phenotypic Suppression |
| FKS1 |
YLR342W |
Catalytic subunit of 1,3-beta-D-glucan synthase |
genetic |
6 |
2 |
4 |
Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BUB3 |
YOR026W |
Kinetochore checkpoint WD40 repeat protein |
genetic |
6 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| FKH1 |
YIL131C |
Forkhead family transcription factor |
regulation |
5 |
3 |
5 |
chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments |
| CDC55 |
YGL190C |
Regulatory subunit B of protein phosphatase 2A (PP2A) |
genetic |
5 |
3 |
5 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Lethality, Synthetic Rescue |
| MIH1 |
YMR036C |
Protein tyrosine phosphatase |
genetic |
5 |
3 |
5 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
genetic |
5 |
3 |
5 |
Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
genetic |
5 |
2 |
5 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue |
| TPM1 |
YNL079C |
Major isoform of tropomyosin |
genetic |
5 |
2 |
5 |
Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
genetic |
5 |
2 |
4 |
Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| MNN10 |
YDR245W |
Subunit of a Golgi mannosyltransferase complex |
genetic |
5 |
2 |
4 |
Positive Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| GAS1 |
YMR307W |
Beta-1,3-glucanosyltransferase required for cell wall assembly |
genetic |
5 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| BNI1 |
YNL271C |
Formin |
genetic |
4 |
3 |
4 |
Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
genetic |
4 |
2 |
4 |
Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Rescue |
| BUB1 |
YGR188C |
Protein kinase involved in the cell cycle checkpoint into anaphase |
genetic |
4 |
2 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue |
| KRE1 |
YNL322C |
Cell wall glycoprotein involved in beta-glucan assembly |
genetic |
4 |
1 |
4 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CDC12 |
YHR107C |
Component of the septin ring that is required for cytokinesis |
genetic |
4 |
3 |
3 |
Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression |
| SEC66 |
YBR171W |
Non-essential subunit of Sec63 complex |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| CSM1 |
YCR086W |
Nucleolar protein that mediates homolog segregation during meiosis I |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| HOC1 |
YJR075W |
Alpha-1,6-mannosyltransferase |
genetic |
4 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic |
| SGS1 |
YMR190C |
RecQ family nucleolar DNA helicase |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| PFY1 |
YOR122C |
Profilin |
genetic |
3 |
3 |
3 |
Synthetic Lethality, Synthetic Growth Defect, Negative Genetic |
| CDC11 |
YJR076C |
Component of the septin ring that is required for cytokinesis |
genetic |
3 |
2 |
3 |
Negative Genetic, Phenotypic Suppression, Negative Genetic |
| GIN4 |
YDR507C |
Protein kinase involved in bud growth and assembly of the septin ring |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression |
| RTS1 |
YOR014W |
B-type regulatory subunit of protein phosphatase 2A (PP2A) |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression |
| HOG1 |
YLR113W |
Mitogen-activated protein kinase involved in osmoregulation |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement |
| ZDS1 |
YMR273C |
Protein with a role in regulating Swe1p-dependent polarized growth |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
| YHC1 |
YLR298C |
Component of the U1 snRNP complex required for pre-mRNA splicing |
genetic |
3 |
2 |
3 |
Positive Genetic, Positive Genetic, Negative Genetic |
| PKC1 |
YBL105C |
Protein serine/threonine kinase |
genetic |
3 |
2 |
3 |
Phenotypic Suppression, Negative Genetic, Negative Genetic |
| ISC1 |
YER019W |
Inositol phosphosphingolipid phospholipase C |
genetic |
3 |
2 |
3 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| ANP1 |
YEL036C |
Subunit of the alpha-1,6 mannosyltransferase complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| WBP1 |
YEL002C |
Beta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| YCS4 |
YLR272C |
Subunit of the condensin complex |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| LRS4 |
YDR439W |
Nucleolar protein that forms a complex with Csm1p |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CCW12 |
YLR110C |
Cell wall mannoprotein |
genetic |
3 |
1 |
3 |
Negative Genetic, Negative Genetic, Negative Genetic |
| CLB2 |
YPR119W |
B-type cyclin involved in cell cycle progression |
genetic |
3 |
3 |
2 |
Phenotypic Suppression, Dosage Growth Defect, Phenotypic Enhancement |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
physical |
3 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western |
| CDC14 |
YFR028C |
Protein phosphatase required for mitotic exit |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression |
| KEL1 |
YHR158C |
Protein required for proper cell fusion and cell morphology |
physical |
3 |
2 |
2 |
Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western |
| NET1 |
YJL076W |
Core subunit of the RENT complex |
genetic |
3 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue |
| BEM2 |
YER155C |
Rho GTPase activating protein (RhoGAP) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| RGA1 |
YOR127W |
GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SMI1 |
YGR229C |
Protein involved in the regulation of cell wall synthesis |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SHE4 |
YOR035C |
Protein containing a UCS (UNC-45/CRO1/SHE4) domain |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| SUT2 |
YPR009W |
Zn2Cys6 family transcription factor |
genetic |
3 |
1 |
2 |
Negative Genetic, Negative Genetic, Negative Genetic |
| HTB1 |
YDR224C |
Histone H2B |
physical |
3 |
2 |
1 |
Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western |
| FKH2 |
YNL068C |
Forkhead family transcription factor |
regulation |
2 |
2 |
2 |
chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments |
| NAP1 |
YKR048C |
Histone chaperone and assembly chaperone for Rps6a/b |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Synthetic Rescue |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
physical |
2 |
2 |
2 |
Biochemical Activity, Affinity Capture-MS |
| CKS1 |
YBR135W |
Cyclin-dependent protein kinase regulatory subunit and adaptor |
physical |
2 |
2 |
2 |
Affinity Capture-MS, Reconstituted Complex |
| DIB1 |
YPR082C |
17-kDa component of the U4/U6aU5 tri-snRNP |
physical |
2 |
2 |
2 |
Biochemical Activity, Two-hybrid |
| HSP82 |
YPL240C |
Hsp90 chaperone |
physical |
2 |
2 |
2 |
Biochemical Activity, Affinity Capture-Western |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| GCN5 |
YGR252W |
Catalytic subunit of ADA and SAGA histone acetyltransferase complexes |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| DMA2 |
YNL116W |
Ubiquitin-protein ligase (E3) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| BFA1 |
YJR053W |
Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Negative Genetic |
| PDS1 |
YDR113C |
Securin |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Enhancement |
| DMA1 |
YHR115C |
Ubiquitin-protein ligase (E3) |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| ZIP1 |
YDR285W |
Transverse filament protein of the synaptonemal complex |
genetic |
2 |
2 |
2 |
Synthetic Rescue, Phenotypic Suppression |
| RAD53 |
YPL153C |
DNA damage response kinase |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Phenotypic Suppression |
| FUS3 |
YBL016W |
Mitogen-activated serine/threonine protein kinase involved in mating |
genetic |
2 |
2 |
2 |
Phenotypic Suppression, Positive Genetic |
| BIM1 |
YER016W |
Microtubule plus end-tracking protein |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Rescue |
| MAD2 |
YJL030W |
Component of the spindle-assembly checkpoint complex |
genetic |
2 |
2 |
2 |
Dosage Rescue, Phenotypic Enhancement |
| CLB1 |
YGR108W |
B-type cyclin involved in cell cycle progression |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Dosage Growth Defect |
| SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
physical |
2 |
2 |
2 |
Biochemical Activity, Affinity Capture-MS |
| RPN4 |
YDL020C |
Transcription factor that stimulates expression of proteasome genes |
genetic |
2 |
2 |
2 |
Negative Genetic, Dosage Growth Defect |
| SLI15 |
YBR156C |
Subunit of the conserved chromosomal passenger complex (CPC) |
genetic |
2 |
2 |
2 |
Negative Genetic, Phenotypic Enhancement |
| SIC1 |
YLR079W |
Cyclin-dependent kinase inhibitor (CKI) |
genetic |
2 |
2 |
2 |
Phenotypic Enhancement, Synthetic Growth Defect |
| ARC18 |
YLR370C |
Subunit of the ARP2/3 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ARC35 |
YNR035C |
Subunit of the ARP2/3 complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| CDC3 |
YLR314C |
Component of the septin ring that is required for cytokinesis |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| LCB1 |
YMR296C |
Component of serine palmitoyltransferase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| YAK1 |
YJL141C |
Serine-threonine protein kinase |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| SWP1 |
YMR149W |
Delta subunit of the oligosaccharyl transferase glycoprotein complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| ZDS2 |
YML109W |
Protein with a role in regulating Swe1p-dependent polarized growth |
genetic |
2 |
1 |
2 |
Phenotypic Suppression, Phenotypic Suppression |
| MCK1 |
YNL307C |
Dual-specificity ser/thr and tyrosine protein kinase |
genetic |
2 |
1 |
2 |
Synthetic Growth Defect, Synthetic Growth Defect |
| CDC34 |
YDR054C |
Ubiquitin-conjugating enzyme (E2) |
physical |
2 |
1 |
2 |
Biochemical Activity, Biochemical Activity |
| OST2 |
YOR103C |
Epsilon subunit of the oligosaccharyltransferase complex |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
physical |
2 |
1 |
2 |
Affinity Capture-RNA, Affinity Capture-RNA |
| ILM1 |
YJR118C |
Protein of unknown function |
genetic |
2 |
1 |
2 |
Negative Genetic, Negative Genetic |
| MIH1 |
YMR036C |
Protein tyrosine phosphatase |
regulation |
2 |
2 |
1 |
co-immunoprecipitation evidence, qualitative western immunoblotting evidence |
| EAF1 |
YDR359C |
Component of the NuA4 histone acetyltransferase complex |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Dosage Lethality |
| PPH22 |
YDL188C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Biochemical Activity |
| PPH21 |
YDL134C |
Catalytic subunit of protein phosphatase 2A, PP2A |
physical |
2 |
2 |
1 |
Reconstituted Complex, Biochemical Activity |
| KIN1 |
YDR122W |
S/T protein kinase |
physical |
2 |
2 |
1 |
Affinity Capture-MS, Affinity Capture-Western |
| SPO12 |
YHR152W |
Nucleolar protein of unknown function |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| IGO1 |
YNL157W |
Protein required for initiation of G0 program |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| PMR1 |
YGL167C |
High affinity Ca2+/Mn2+ P-type ATPase |
genetic |
2 |
2 |
1 |
Phenotypic Suppression, Phenotypic Enhancement |
| IGO2 |
YHR132W-A |
Protein required for initiation of G0 program |
genetic |
2 |
2 |
1 |
Synthetic Rescue, Phenotypic Suppression |
| ACT1 |
YFL039C |
Actin, structural protein in cytoskeleton |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| STT3 |
YGL022W |
Catalytic subunit of the oligosaccharyltransferase complex of the ER l |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| CDC1 |
YDR182W |
Putative mannose-ethanolamine phosphate phosphodiesterase |
genetic |
2 |
1 |
1 |
Negative Genetic, Negative Genetic |
| STE12 |
YHR084W |
Transcription factor that is activated by a MAPK signaling cascade |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RFX1 |
YLR176C |
Major transcriptional repressor of DNA-damage-regulated genes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TEC1 |
YBR083W |
Transcription factor targeting filamentation genes and Ty1 expression |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MED2 |
YDL005C |
Subunit of the RNA polymerase II mediator complex |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| TFC7 |
YOR110W |
RNA pol III transcription initiation factor complex (TFIIIC) subunit |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| CDC28 |
YBR160W |
Cyclin-dependent kinase (CDK) catalytic subunit |
regulation |
1 |
1 |
1 |
quantitative mass spectrometry evidence |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| RPD3 |
YNL330C |
Histone deacetylase, component of both the Rpd3S and Rpd3L complexes |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| SWI6 |
YLR182W |
Transcription cofactor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| MBP1 |
YDL056W |
Transcription factor |
regulation |
1 |
1 |
1 |
chromatin immunoprecipitation-chip evidence |
| HSL1 |
YKL101W |
Nim1p-related protein kinase |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
regulation |
1 |
1 |
1 |
protein kinase assay evidence |
| LEO1 |
YOR123C |
Component of the Paf1 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CKA2 |
YOR061W |
Alpha' catalytic subunit of casein kinase 2 (CK2) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CKB1 |
YGL019W |
Beta regulatory subunit of casein kinase 2 (CK2) |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| BFR2 |
YDR299W |
Component of the SSU and 90S preribosomes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLC7 |
YER133W |
Type 1 S/T protein phosphatase (PP1) catalytic subunit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| STT4 |
YLR305C |
Phosphatidylinositol-4-kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DRS1 |
YLL008W |
Nucleolar DEAD-box protein required for ribosome assembly and function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ERB1 |
YMR049C |
Constituent of 66S pre-ribosomal particles |
physical |
1 |
1 |
1 |
Biochemical Activity |
| AXL2 |
YIL140W |
Integral plasma membrane protein |
genetic |
1 |
1 |
1 |
Dosage Rescue |
| IMH1 |
YLR309C |
Protein involved in vesicular transport |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PFK27 |
YOL136C |
6-phosphofructo-2-kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| POP4 |
YBR257W |
Subunit of both RNase MRP and nuclear RNase P |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NSE4 |
YDL105W |
Component of the SMC5-SMC6 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC42 |
YLR229C |
Small rho-like GTPase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| FRT2 |
YAL028W |
Tail-anchored ER membrane protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ARC1 |
YGL105W |
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NSR1 |
YGR159C |
Nucleolin, nucleolar protein that binds nuclear localization sequences |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LSM1 |
YJL124C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| LSM6 |
YDR378C |
Lsm (Like Sm) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPB5 |
YBR154C |
RNA polymerase subunit ABC27 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPA190 |
YOR341W |
RNA polymerase I largest subunit A190 |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RPA43 |
YOR340C |
RNA polymerase I subunit A43 |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SUB2 |
YDL084W |
Component of the TREX complex required for nuclear mRNA export |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| RSC6 |
YCR052W |
Component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ILS1 |
YBL076C |
Cytoplasmic isoleucine-tRNA synthetase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| REI1 |
YBR267W |
Cytoplasmic pre-60S factor |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT16 |
YGL207W |
Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RPN6 |
YDL097C |
Essential, non-ATPase regulatory subunit of the 26S proteasome lid |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPG1 |
YBR079C |
eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PRE7 |
YBL041W |
Beta 6 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| CCR4 |
YAL021C |
Component of the CCR4-NOT transcriptional complex |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RNT1 |
YMR239C |
Nuclear dsRNA-specific ribonuclease (RNase III) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ABD1 |
YBR236C |
Methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| APC2 |
YLR127C |
Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| BEM1 |
YBR200W |
Protein containing SH3-domains |
physical |
1 |
1 |
1 |
Two-hybrid |
| BUD14 |
YAR014C |
Protein involved in bud-site selection |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| AIM21 |
YIR003W |
Subunit of a complex that associates with actin filaments |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC24 |
YAL041W |
Guanine nucleotide exchange factor (GEF) for Cdc42p |
physical |
1 |
1 |
1 |
Two-hybrid |
| DBP10 |
YDL031W |
Putative ATP-dependent RNA helicase of the DEAD-box protein family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RIX1 |
YHR197W |
Component of the Rix1 complex and possibly pre-replicative complexes |
genetic |
1 |
1 |
1 |
Positive Genetic |
| AVO1 |
YOL078W |
Component of the membrane-bound TORC2 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CIP1 |
YPL014W |
Cyclin-dependent kinase inhibitor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| COP1 |
YDL145C |
Alpha subunit of COPI vesicle coatomer complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CTK1 |
YKL139W |
Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| EDE1 |
YBL047C |
Scaffold protein involved in the formation of early endocytic sites |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CCT4 |
YDL143W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLO3 |
YER122C |
ADP-ribosylation factor GTPase activating protein (ARF GAP) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| HAT1 |
YPL001W |
Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| BDF2 |
YDL070W |
Protein involved in transcription initiation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| DYN1 |
YKR054C |
Cytoplasmic heavy chain dynein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| DHH1 |
YDL160C |
Cytoplasmic DEAD-box helicase and mRNA decapping activator |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| HIF1 |
YLL022C |
Non-essential component of the HAT-B histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ISW1 |
YBR245C |
ATPase subunit of imitation-switch (ISWI) class chromatin remodelers |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| KIN3 |
YAR018C |
Nonessential serine/threonine protein kinase |
physical |
1 |
1 |
1 |
Two-hybrid |
| DIB1 |
YPR082C |
17-kDa component of the U4/U6aU5 tri-snRNP |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MCD1 |
YDL003W |
Essential alpha-kleisin subunit of the cohesin complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| HSC82 |
YMR186W |
Cytoplasmic chaperone of the Hsp90 family |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| MRPL24 |
YMR193W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HDA2 |
YDR295C |
Subunit of HDA1 histone deacetylase complex |
physical |
1 |
1 |
1 |
Two-hybrid |
| MLC1 |
YGL106W |
Essential light chain for Myo1p |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CMD1 |
YBR109C |
Calmodulin |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| MYO2 |
YOR326W |
Type V myosin motor involved in actin-based transport of cargos |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| HTZ1 |
YOL012C |
Histone variant H2AZ |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| KAP114 |
YGL241W |
Karyopherin, responsible for nuclear import of specific proteins |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| KCC4 |
YCL024W |
Protein kinase of the bud neck involved in the septin checkpoint |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ARP8 |
YOR141C |
Nuclear actin-related protein involved in chromatin remodeling |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NMD3 |
YHR170W |
Protein involved in nuclear export of the large ribosomal subunit |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ATG18 |
YFR021W |
Phosphoinositide binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ORC2 |
YBR060C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PCF11 |
YDR228C |
mRNA 3' end processing factor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PFK1 |
YGR240C |
Alpha subunit of heterooctameric phosphofructokinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| POP2 |
YNR052C |
Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| HSP82 |
YPL240C |
Hsp90 chaperone |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| PRE4 |
YFR050C |
Beta 7 subunit of the 20S proteasome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CWC22 |
YGR278W |
Spliceosome-associated protein that is required for pre-mRNA splicing |
genetic |
1 |
1 |
1 |
Negative Genetic |
| LIN1 |
YHR156C |
Non-essential component of U5 snRNP |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NUD1 |
YOR373W |
Mitotic exit network (MEN) scaffold protein |
physical |
1 |
1 |
1 |
PCA |
| NUD1 |
YOR373W |
Mitotic exit network (MEN) scaffold protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BUD21 |
YOR078W |
Component of small ribosomal subunit (SSU) processosome |
physical |
1 |
1 |
1 |
Biochemical Activity |
| GCN20 |
YFR009W |
Positive regulator of the Gcn2p kinase activity |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MED8 |
YBR193C |
Subunit of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| IWR1 |
YDL115C |
RNA polymerase II transport factor, conserved from yeast to humans |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RPC11 |
YDR045C |
RNA polymerase III subunit C11 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CTI6 |
YPL181W |
Component of the Rpd3L histone deacetylase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SCS2 |
YER120W |
Integral ER membrane protein, regulates phospholipid metabolism |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SEC27 |
YGL137W |
Essential beta'-coat protein of the COPI coatomer |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC23 |
YPR181C |
GTPase-activating protein, stimulates the GTPase activity of Sar1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC62 |
YPL094C |
Essential subunit of Sec63 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC63 |
YOR254C |
Essential subunit of Sec63 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| HOS4 |
YIL112W |
Subunit of the Set3 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIN3 |
YOL004W |
Component of both the Rpd3S and Rpd3L histone deacetylase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SIR2 |
YDL042C |
Conserved NAD+ dependent histone deacetylase of the Sirtuin family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SMC1 |
YFL008W |
Subunit of the multiprotein cohesin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GAL83 |
YER027C |
One of three alternate beta-subunits of the Snf1 kinase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SAK1 |
YER129W |
Upstream serine/threonine kinase for the SNF1 complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SPO7 |
YAL009W |
Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFK2 |
YMR205C |
Beta subunit of heterooctameric phosphofructokinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NGG1 |
YDR176W |
Subunit of chromatin modifying histone acetyltransferase complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SSL1 |
YLR005W |
Subunit of the core form of RNA polymerase transcription factor TFIIH |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ROM2 |
YLR371W |
Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PTC1 |
YDL006W |
Type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| SPT8 |
YLR055C |
Subunit of the SAGA transcriptional regulatory complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CCT6 |
YDR188W |
Subunit of the cytosolic chaperonin Cct ring complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC98 |
YNL126W |
Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| DRE2 |
YKR071C |
Component of the cytosolic Fe-S protein assembly (CIA) machinery |
physical |
1 |
1 |
1 |
Biochemical Activity |
| BDH2 |
YAL061W |
Putative medium-chain alcohol dehydrogenase with similarity to BDH1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HEK2 |
YBL032W |
RNA binding protein involved in asymmetric localization of ASH1 mRNA |
physical |
1 |
1 |
1 |
Affinity Capture-RNA |
| GET4 |
YOR164C |
Protein involved in inserting tail-anchored proteins into ER membranes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC13 |
YDL220C |
Single stranded DNA-binding protein found at TG1-3 telomere G-tails |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRZ1 |
YNL027W |
Transcription factor, activates transcription of stress response genes |
physical |
1 |
1 |
1 |
Biochemical Activity |
| HYP2 |
YEL034W |
Translation elongation factor eIF-5A |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PHO85 |
YPL031C |
Cyclin-dependent kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| RIM15 |
YFL033C |
Protein kinase involved in cell proliferation in response to nutrients |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| APP1 |
YNL094W |
Phosphatidate phosphatase, converts phosphatidate to diacylglycerol |
physical |
1 |
1 |
1 |
Two-hybrid |
| SAC6 |
YDR129C |
Fimbrin, actin-bundling protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| PTC5 |
YOR090C |
Mitochondrial type 2C protein phosphatase (PP2C) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| ENV7 |
YPL236C |
Vacuolar membrane protein kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CLN1 |
YMR199W |
G1 cyclin involved in regulation of the cell cycle |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| RAS1 |
YOR101W |
GTPase involved in G-protein signaling in adenylate cyclase activation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PBR1 |
YNL181W |
Putative oxidoreductase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MET30 |
YIL046W |
F-box protein containing five copies of the WD40 motif |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| KNS1 |
YLL019C |
Protein kinase involved in negative regulation of PolIII transcription |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| SKP1 |
YDR328C |
Evolutionarily conserved kinetochore protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SUV3 |
YPL029W |
ATP-dependent RNA helicase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| HSL7 |
YBR133C |
Protein arginine N-methyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| KEL2 |
YGR238C |
Protein that negatively regulates mitotic exit |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| KIN2 |
YLR096W |
S/T protein kinase |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CHS1 |
YNL192W |
Chitin synthase I |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CDC123 |
YLR215C |
Assembly factor for the eIF2 translation initiation factor complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SLT2 |
YHR030C |
Serine/threonine MAP kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| KIN28 |
YDL108W |
Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MSS116 |
YDR194C |
Mitochondrial transcription elongation factor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| CIK1 |
YMR198W |
Kinesin-associated protein |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| MIH1 |
YMR036C |
Protein tyrosine phosphatase |
physical |
1 |
1 |
1 |
Affinity Capture-Western |
| OMS1 |
YDR316W |
Protein integral to the mitochondrial membrane |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SKI2 |
YLR398C |
Ski complex component and putative RNA helicase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| AHC1 |
YOR023C |
Subunit of the Ada histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| UBP15 |
YMR304W |
Ubiquitin-specific protease involved in protein deubiquitination |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| YNG2 |
YHR090C |
Subunit of NuA4, an essential histone acetyltransferase complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YGR153W |
YGR153W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TRZ1 |
YKR079C |
tRNA 3'-end processing endonuclease tRNase Z |
physical |
1 |
1 |
1 |
Biochemical Activity |
| USB1 |
YLR132C |
Putative poly(U)-specific 3'-to-5' RNA exonuclease |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBX5 |
YDR330W |
UBX domain-containing protein that interacts with Cdc48p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YML037C |
YML037C |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YER079W |
YER079W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YER079W |
YER079W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| URN1 |
YPR152C |
Protein of unknown function containing WW and FF domains |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YAT2 |
YER024W |
Carnitine acetyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YME1 |
YPR024W |
Catalytic subunit of i-AAA protease complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TPO1 |
YLL028W |
Polyamine transporter of the major facilitator superfamily |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBC8 |
YEL012W |
Ubiquitin-conjugating enzyme that regulates gluconeogenesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YGR017W |
YGR017W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UBP10 |
YNL186W |
Ubiquitin-specific protease, deubiquitinates Ub-protein moieties |
physical |
1 |
1 |
1 |
Biochemical Activity |
| VID27 |
YNL212W |
Cytoplasmic protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| TAF12 |
YDR145W |
Subunit (61/68 kDa) of TFIID and SAGA complexes |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YPT10 |
YBR264C |
Rab family GTP-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| YLR125W |
YLR125W |
Putative protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| UTP25 |
YIL091C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| WHI3 |
YNL197C |
RNA binding protein that modulates mRNA stability |
physical |
1 |
1 |
1 |
Protein-RNA |
| VPS29 |
YHR012W |
Subunit of the membrane-associated retromer complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| VPS35 |
YJL154C |
Endosomal subunit of membrane-associated retromer complex |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| TRM112 |
YNR046W |
Protein involved in methylation of tRNA, rRNA, and translation factors |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| TRP3 |
YKL211C |
Indole-3-glycerol-phosphate synthase |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| UBA4 |
YHR111W |
E1-like protein that activates Urm1p before urmylation |
physical |
1 |
1 |
1 |
Two-hybrid |
| TYE7 |
YOR344C |
Serine-rich protein that contains a bHLH DNA binding motif |
physical |
1 |
1 |
1 |
Two-hybrid |
| XRN1 |
YGL173C |
Evolutionarily-conserved 5'-3' exonuclease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCK1 |
YHR135C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YCK2 |
YNL154C |
Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| YPD1 |
YDL235C |
Osmotic stress-responsive phosphorelay intermediate sensor protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TOS3 |
YGL179C |
Protein kinase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SWI4 |
YER111C |
DNA binding component of the SBF complex (Swi4p-Swi6p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YPI1 |
YFR003C |
Regulatory subunit of the type I protein phosphatase (PP1) Glc7p |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TEL2 |
YGR099W |
Subunit of the ASTRA complex, involved in chromatin remodeling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YEF1 |
YEL041W |
ATP-NADH kinase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YGR038C-A |
YGR038C-A |
Retrotransposon TYA Gag gene co-transcribed with TYB Pol |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YNL108C |
YNL108C |
Protein phosphatase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| THO1 |
YER063W |
Conserved nuclear RNA-binding protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YKR075C |
YKR075C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| UGP1 |
YKL035W |
UDP-glucose pyrophosphorylase (UGPase) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YMR295C |
YMR295C |
Protein of unknown function that associates with ribosomes |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| YJL070C |
YJL070C |
Putative metallo-dependent hydrolase superfamily protein |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| TIF1 |
YKR059W |
Translation initiation factor eIF4A |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| TOS8 |
YGL096W |
Homeodomain-containing protein and putative transcription factor |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| TSC3 |
YBR058C-A |
Protein that stimulates the activity of serine palmitoyltransferase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YPK1 |
YKL126W |
S/T protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| YPK2 |
YMR104C |
AGC-type S/T protein kinase |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| TGL3 |
YMR313C |
Bifunctional triacylglycerol lipase and LPE acyltransferase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TGL4 |
YKR089C |
Multifunctional lipase/hydrolase/phospholipase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| TIF34 |
YMR146C |
eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TIM50 |
YPL063W |
Essential component of the TIM23 complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| YPL039W |
YPL039W |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Positive Genetic |
| TFC1 |
YBR123C |
Subunit of RNA polymerase III transcription initiation factor complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TFB1 |
YDR311W |
Subunit of TFIIH and nucleotide excision repair factor 3 complexes |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCG1 |
YDR325W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VRG4 |
YGL225W |
Golgi GDP-mannose transporter |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBA1 |
YKL210W |
Ubiquitin activating enzyme (E1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TSR4 |
YOL022C |
Cytoplasmic assembly chaperone for ribosomal protein Rps2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TCP1 |
YDR212W |
Alpha subunit of chaperonin-containing T-complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YCL049C |
YCL049C |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YDR003W-A |
YDR003W-A |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VMA3 |
YEL027W |
Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| UBP11 |
YKR098C |
Ubiquitin-specific protease |
genetic |
1 |
1 |
1 |
Negative Genetic |
| TRM12 |
YML005W |
S-adenosylmethionine-dependent methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| VAN1 |
YML115C |
Component of the mannan polymerase I |
genetic |
1 |
1 |
1 |
Negative Genetic |
| YAF9 |
YNL107W |
Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| NOP53 |
YPL146C |
Nucleolar protein |
physical |
1 |
1 |
1 |
Two-hybrid |
| ASR1 |
YPR093C |
Ubiquitin ligase that modifies and regulates RNA Pol II |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| EAP1 |
YKL204W |
eIF4E-associated protein, competes with eIF4G for binding to eIF4E |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CIA1 |
YDR267C |
Component of cytosolic iron-sulfur protein assembly (CIA) machinery |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RLF2 |
YPR018W |
Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF2 |
YGR092W |
Ser/Thr kinase involved in transcription and stress response |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SKT5 |
YBL061C |
Activator of Chs3p (chitin synthase III) during vegetative growth |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PMI40 |
YER003C |
Mannose-6-phosphate isomerase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO13 |
YHR014W |
Meiotic regulator |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BIR1 |
YJR089W |
Subunit of chromosomal passenger complex (CPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNA5 |
YLR231C |
Kynureninase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| JJJ1 |
YNL227C |
Co-chaperone that stimulates the ATPase activity of Ssa1p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SRV2 |
YNL138W |
CAP (cyclase-associated protein) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC24 |
YMR117C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DCK1 |
YLR422W |
Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PRS1 |
YKL181W |
5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| EBS1 |
YDR206W |
Protein involved in translation inhibition and nonsense-mediated decay |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SMT3 |
YDR510W |
Ubiquitin-like protein of the SUMO family |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| HSP10 |
YOR020C |
Mitochondrial matrix co-chaperonin |
genetic |
1 |
1 |
1 |
Positive Genetic |
| NUP57 |
YGR119C |
FG-nucleoporin component of central core of the nuclear pore complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NDL1 |
YLR254C |
Homolog of nuclear distribution factor NudE |
physical |
1 |
1 |
1 |
Two-hybrid |
| NDL1 |
YLR254C |
Homolog of nuclear distribution factor NudE |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ALY2 |
YJL084C |
Alpha arrestin, Ub-ligase adaptor for Rsp5p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SPC72 |
YAL047C |
Gamma-tubulin small complex (gamma-TuSC) receptor |
physical |
1 |
1 |
1 |
Two-hybrid |
| IPL1 |
YPL209C |
Aurora kinase of chromosomal passenger complex |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MDR1 |
YGR100W |
Cytoplasmic GTPase-activating protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| RPL4A |
YBR031W |
Ribosomal 60S subunit protein L4A |
genetic |
1 |
1 |
1 |
Negative Genetic |
| NNF1 |
YJR112W |
Essential component of the outer kinetochore MIND complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RFT1 |
YBL020W |
Membrane protein required for translocation of Man5GlcNac2-PP-Dol |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC31 |
YOR257W |
Calcium-binding component of the spindle pole body (SPB) half-bridge |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SWC5 |
YBR231C |
Component of the SWR1 complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CBF1 |
YJR060W |
Basic helix-loop-helix (bHLH) protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS1A |
YLR441C |
Ribosomal protein of the small (40S) subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPS8A |
YBL072C |
Protein component of the small (40S) ribosomal subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD9 |
YDR217C |
DNA damage-dependent checkpoint protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| BRN1 |
YBL097W |
Subunit of the condensin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD4 |
YJR092W |
Anillin-like protein involved in bud-site selection |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CLB5 |
YPR120C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CLC1 |
YGR167W |
Clathrin light chain |
physical |
1 |
1 |
1 |
Biochemical Activity |
| COX18 |
YGR062C |
Protein required for membrane insertion of C-terminus of Cox2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| DBF4 |
YDR052C |
Regulatory subunit of Cdc7p-Dbf4p kinase complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DCD1 |
YHR144C |
Deoxycytidine monophosphate (dCMP) deaminase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KAR3 |
YPR141C |
Minus-end-directed microtubule motor |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| KAR9 |
YPL269W |
Spindle positioning factor |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| MAD1 |
YGL086W |
Coiled-coil protein involved in spindle-assembly checkpoint |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| MCM3 |
YEL032W |
Protein involved in DNA replication |
genetic |
1 |
1 |
1 |
Negative Genetic |
| MPS1 |
YDL028C |
Dual-specificity kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIK1 |
YCL029C |
Microtubule-associated protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CBF2 |
YGR140W |
Essential kinetochore protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST3 |
YOR085W |
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PEA2 |
YER149C |
Coiled-coil 12S polarisome subunit |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| REC102 |
YLR329W |
Protein involved in early stages of meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| SEC6 |
YIL068C |
Essential 88kDa subunit of the exocyst complex |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SED5 |
YLR026C |
cis-Golgi t-SNARE syntaxin |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RRD1 |
YIL153W |
Peptidyl-prolyl cis/trans-isomerase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SSN3 |
YPL042C |
Component of the RNA polymerase II mediator complex |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SSS1 |
YDR086C |
Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| STE20 |
YHL007C |
Cdc42p-activated signal transducing kinase |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| STU1 |
YBL034C |
Microtubule plus-end-tracking non-motor protein |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| PEP8 |
YJL053W |
Vacuolar protein component of the retromer |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| CNM67 |
YNL225C |
Component of the spindle pole body outer plaque |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CST9 |
YLR394W |
SUMO E3 ligase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| JNM1 |
YMR294W |
Component of the yeast dynactin complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SPC110 |
YDR356W |
Inner plaque spindle pole body (SPB) component |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| SSN2 |
YDR443C |
Subunit of the RNA polymerase II mediator complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RSM19 |
YNR037C |
Mitochondrial ribosomal protein of the small subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| OST4 |
YDL232W |
Subunit of the oligosaccharyltransferase complex of the ER lumen |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SFK1 |
YKL051W |
Protein that regulates phospholipid asymmetry at plasma membrane |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MPT5 |
YGL178W |
mRNA-binding protein of the PUF family |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CSG2 |
YBR036C |
Endoplasmic reticulum membrane protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SEC2 |
YNL272C |
Guanyl-nucleotide exchange factor for the small G-protein Sec4p |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLN1 |
YIL147C |
Transmembrane histidine phosphotransfer kinase and osmosensor |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CCS1 |
YMR038C |
Copper chaperone for superoxide dismutase Sod1p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BNR1 |
YIL159W |
Formin |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| RAD2 |
YGR258C |
Single-stranded DNA endonuclease |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| FCP1 |
YMR277W |
Carboxy-terminal domain (CTD) phosphatase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BUD6 |
YLR319C |
Actin- and formin-interacting protein |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| DOT1 |
YDR440W |
Nucleosomal histone H3-Lys79 methylase |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| MON1 |
YGL124C |
Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PET309 |
YLR067C |
Specific translational activator for the COX1 mRNA |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| IVY1 |
YDR229W |
Phospholipid-binding protein that interacts with both Ypt7p and Vps33p |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SPA2 |
YLL021W |
Component of the polarisome |
genetic |
1 |
1 |
1 |
Synthetic Lethality |
| SPC25 |
YER018C |
Component of the kinetochore-associated Ndc80 complex |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPC29 |
YPL124W |
Inner plaque spindle pole body (SPB) component |
physical |
1 |
1 |
1 |
Affinity Capture-MS |
| SPC42 |
YKL042W |
Central plaque component of spindle pole body (SPB) |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| STU2 |
YLR045C |
Microtubule polymerase of the XMAP215/Dis1 family |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| CLA4 |
YNL298W |
Cdc42p-activated signal transducing kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MFA2 |
YNL145W |
Mating pheromone a-factor |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CAP2 |
YIL034C |
Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NUP188 |
YML103C |
Subunit of the inner ring of the nuclear pore complex (NPC) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| CIN2 |
YPL241C |
GTPase-activating protein (GAP) for Cin4p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| EAF6 |
YJR082C |
Subunit of the NuA4 acetyltransferase complex |
physical |
1 |
1 |
1 |
Reconstituted Complex |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ORM2 |
YLR350W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| PRP24 |
YMR268C |
Splicing factor that reanneals snRNPs during spliceosome recycling |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SAC7 |
YDR389W |
GTPase activating protein (GAP) for Rho1p |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| COY1 |
YKL179C |
Golgi membrane protein with similarity to mammalian CASP |
physical |
1 |
1 |
1 |
Two-hybrid |
| PAC1 |
YOR269W |
Regulator of dynein, involved in intracellular transport |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PTR3 |
YFR029W |
Component of the SPS plasma membrane amino acid sensor system |
physical |
1 |
1 |
1 |
Biochemical Activity |
| OKP1 |
YGR179C |
Outer kinetochore protein required for accurate chromosome segregation |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPT23 |
YKL020C |
ER membrane protein involved in regulation of OLE1 transcription |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| PLP2 |
YOR281C |
Protein that interacts with the CCT complex to stimulate actin folding |
genetic |
1 |
1 |
1 |
Positive Genetic |
| STH1 |
YIL126W |
ATPase component of the RSC chromatin remodeling complex |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| BCH2 |
YKR027W |
Member of the ChAPs (Chs5p-Arf1p-binding proteins) family |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MIG2 |
YGL209W |
Zinc finger transcriptional repressor |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ESBP6 |
YNL125C |
Protein with similarity to monocarboxylate permeases |
physical |
1 |
1 |
1 |
Biochemical Activity |
| KEX1 |
YGL203C |
Cell death protease essential for hypochlorite-induced apoptosis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RPL40A |
YIL148W |
Ubiquitin-ribosomal 60S subunit protein L40A fusion protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RPL40B |
YKR094C |
Ubiquitin-ribosomal 60S subunit protein L40B fusion protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PAH1 |
YMR165C |
Mg2+-dependent phosphatidate (PA) phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| HRQ1 |
YDR291W |
3'-5' DNA helicase of the conserved RecQ family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KCS1 |
YDR017C |
Inositol hexakisphosphate and inositol heptakisphosphate kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SRP40 |
YKR092C |
Nucleolar serine-rich protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SPO75 |
YLL005C |
Meiosis-specific protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| KXD1 |
YGL079W |
Subunit of the BLOC-1 complex involved in endosomal maturation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| GUK1 |
YDR454C |
Guanylate kinase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SLX8 |
YER116C |
Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex |
physical |
1 |
1 |
1 |
Biochemical Activity |
| DDR48 |
YMR173W |
DNA damage-responsive protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MET12 |
YPL023C |
Protein with MTHFR activity in vitro |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CAB4 |
YGR277C |
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| ORC4 |
YPR162C |
Subunit of the origin recognition complex (ORC) |
genetic |
1 |
1 |
1 |
Negative Genetic |
| AQY3 |
YFL054C |
Putative channel-like protein |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ELF1 |
YKL160W |
Transcription elongation factor with a conserved zinc finger domain |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CBS1 |
YDL069C |
Mitochondrial translational activator of the COB mRNA |
genetic |
1 |
1 |
1 |
Positive Genetic |
| KAE1 |
YKR038C |
Highly conserved ATPase of HSP70/DnaK family |
genetic |
1 |
1 |
1 |
Negative Genetic |
| BIL1 |
YOR304C-A |
Protein that binds Bud6p and has a role in actin cable assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMP41 |
YNL168C |
Putative protein of unknown function |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GLN4 |
YOR168W |
Glutamine tRNA synthetase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRPL32 |
YCR003W |
Mitochondrial ribosomal protein of the large subunit |
genetic |
1 |
1 |
1 |
Negative Genetic |
| PFK26 |
YIL107C |
6-phosphofructo-2-kinase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PTH2 |
YBL057C |
One of two mitochondrially-localized peptidyl-tRNA hydrolases |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RIM4 |
YHL024W |
Putative RNA-binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| OGG1 |
YML060W |
Nuclear and mitochondrial glycosylase/lyase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEH1 |
YGL100W |
Subunit of the Nup84 nuclear pore and SEACAT subcomplexes |
physical |
1 |
1 |
1 |
Biochemical Activity |
| BST1 |
YFL025C |
GPI inositol deacylase of the endoplasmic reticulum (ER) |
genetic |
1 |
1 |
1 |
Positive Genetic |
| ABP140 |
YOR239W |
AdoMet-dependent tRNA methyltransferase and actin binding protein |
physical |
1 |
1 |
1 |
Biochemical Activity |
| FPS1 |
YLL043W |
Aquaglyceroporin, plasma membrane channel |
physical |
1 |
1 |
1 |
Biochemical Activity |
| GPI12 |
YMR281W |
ER membrane protein involved in the second step of GPI anchor assembly |
genetic |
1 |
1 |
1 |
Negative Genetic |
| IRC5 |
YFR038W |
Putative ATPase containing the DEAD/H helicase-related sequence motif |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ORM1 |
YGR038W |
Protein that mediates sphingolipid homeostasis |
genetic |
1 |
1 |
1 |
Synthetic Rescue |
| DGR2 |
YKL121W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| PTP1 |
YDL230W |
Phosphotyrosine-specific protein phosphatase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SCT1 |
YBL011W |
Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RGD3 |
YHR182W |
GTPase activating protein (GAP) for Rho3p, involved in cell polarity g |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MET2 |
YNL277W |
L-homoserine-O-acetyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| NSG1 |
YHR133C |
Protein involved in regulation of sterol biosynthesis |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SUB1 |
YMR039C |
Transcriptional regulator |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SSF2 |
YDR312W |
Protein required for ribosomal large subunit maturation |
physical |
1 |
1 |
1 |
Biochemical Activity |
| CHS7 |
YHR142W |
Protein of unknown function |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RCI37 |
YIL077C |
Protein that associates with the large mitoribosomal subunit |
physical |
1 |
1 |
1 |
Biochemical Activity |
| MRX3 |
YBL095W |
Protein that associates with mitochondrial ribosome |
physical |
1 |
1 |
1 |
Biochemical Activity |
| LOA1 |
YPR139C |
Lysophosphatidic acid acyltransferase |
physical |
1 |
1 |
1 |
Biochemical Activity |
| RTT106 |
YNL206C |
Histone chaperone |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SUN4 |
YNL066W |
Cell wall protein related to glucanases localized in birth scars |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SVF1 |
YDR346C |
Protein with a potential role in cell survival pathways |
physical |
1 |
1 |
1 |
Biochemical Activity |
| SDS23 |
YGL056C |
Protein involved in cell separation during budding |
physical |
1 |
1 |
1 |
Biochemical Activity |
| ALG6 |
YOR002W |
ER-luminal alpha 1,3 glucosyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SCD6 |
YPR129W |
Repressor of translation initiation |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| GPI19 |
YDR437W |
Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CDC50 |
YCR094W |
Endosomal protein that interacts with phospholipid flippase Drs2p |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPO11 |
YHL022C |
Meiosis-specific protein required for meiotic recombination |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| CLB6 |
YGR109C |
B-type cyclin involved in DNA replication during S phase |
genetic |
1 |
1 |
1 |
Phenotypic Enhancement |
| RPH1 |
YER169W |
JmjC domain-containing histone demethylase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| FMC1 |
YIL098C |
Mitochondrial matrix protein |
genetic |
1 |
1 |
1 |
Negative Genetic |
| GPI10 |
YGL142C |
Integral membrane protein involved in GPI anchor synthesis |
genetic |
1 |
1 |
1 |
Negative Genetic |
| CRD1 |
YDL142C |
Cardiolipin synthase |
genetic |
1 |
1 |
1 |
Phenotypic Suppression |
| CMC2 |
YBL059C-A |
Protein involved in respiratory chain complex assembly or maintenance |
genetic |
1 |
1 |
1 |
Positive Genetic |
| DFR1 |
YOR236W |
Dihydrofolate reductase involved in tetrahydrofolate biosynthesis |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PET100 |
YDR079W |
Chaperone that facilitates the assembly of cytochrome c oxidase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SFM1 |
YOR021C |
SPOUT methyltransferase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SEC12 |
YNR026C |
Guanine nucleotide exchange factor (GEF) |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SPR3 |
YGR059W |
Sporulation-specific homolog of the CDC3/10/11/12 family of genes |
physical |
1 |
1 |
1 |
Two-hybrid |
| ICE2 |
YIL090W |
Integral ER membrane protein with type-III transmembrane domains |
genetic |
1 |
1 |
1 |
Synthetic Growth Defect |
| NRK1 |
YNL129W |
Nicotinamide riboside kinase |
genetic |
1 |
1 |
1 |
Negative Genetic |
| RAD61 |
YDR014W |
Subunit of a complex that inhibits sister chromatid cohesion |
genetic |
1 |
1 |
1 |
Positive Genetic |
| MRX4 |
YPL168W |
Protein that associates with mitochondrial ribosome |
genetic |
1 |
1 |
1 |
Positive Genetic |
| PCD1 |
YLR151C |
8-oxo-dGTP diphosphatase |
genetic |
1 |
1 |
1 |
Positive Genetic |
| SOG2 |
YOR353C |
Key component of the RAM signaling network |
genetic |
1 |
1 |
1 |
Negative Genetic |
| SPS22 |
YCL048W |
Protein of unknown function |
genetic |
1 |
1 |
1 |
Dosage Growth Defect |
| SHH4 |
YLR164W |
Putative alternate subunit of succinate dehydrogenase (SDH) |
genetic |
1 |
1 |
1 |
Negative Genetic |
