Standard name Systematic name Name description Description
BIM1 YER016W Microtubule plus end-tracking protein Microtubule plus end-tracking protein; forms a complex with Kar9p that makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally; homolog of human end binding protein 1 (EB1)
Visualize the interactome of BIM1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 58

CYCLoPs localization & abundance

WT1 WT2 WT3
Endosome 0.243 NaN 0.075
Mito 0.222 0.408 0.113
Nucleolus 0.433 0.510 0.415
Peroxisome 0.081 NaN NaN
SpindlePole 0.546 0.133 0.604
Vac/Vac Memb NaN 0.153 NaN
Nucleus NaN NaN 0.075

GFP localization & abundance

GFP localization GFP abundance
microtubule 3630

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
BIM1 0 2 0 1 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
KAR9 YPL269W Spindle positioning factor physical 16 5 11 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Co-fractionation, Two-hybrid, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-MS
BIK1 YCL029C Microtubule-associated protein physical 13 7 6 Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Co-crystal Structure, Protein-peptide, Reconstituted Complex
BIK1 YCL029C Microtubule-associated protein genetic 12 3 10 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 11 4 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 11 3 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 11 4 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
KIP2 YPL155C Kinesin-related motor protein involved in mitotic spindle positioning genetic 10 4 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 10 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DYN1 YKR054C Cytoplasmic heavy chain dynein genetic 10 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic
JNM1 YMR294W Component of the yeast dynactin complex genetic 10 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 10 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 10 2 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 10 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 9 3 9 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 9 4 8 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 9 3 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 9 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
PAC1 YOR269W Regulator of dynein, involved in intracellular transport genetic 9 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 8 2 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 8 2 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 8 2 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 8 3 7 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 8 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 8 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 8 4 6 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
NIP100 YPL174C Large subunit of the dynactin complex genetic 8 4 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 8 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 8 2 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex physical 8 4 5 Two-hybrid, Two-hybrid, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-MS
SWC5 YBR231C Component of the SWR1 complex genetic 7 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 7 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 7 2 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 7 2 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 7 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 6 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 6 3 6 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Negative Genetic
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 6 2 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 6 2 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 6 3 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 6 2 5 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family physical 6 3 4 Two-hybrid, Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 6 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 5 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 5 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
IRC15 YPL017C Microtubule associated protein genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 5 2 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 5 3 4 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic
DYN3 YMR299C Dynein light intermediate chain (LIC) genetic 5 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 5 2 4 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality
BIM1 YER016W Microtubule plus end-tracking protein physical 5 4 3 Affinity Capture-Western, Two-hybrid, Co-crystal Structure, Co-crystal Structure, Reconstituted Complex
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 5 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
CIN8 YEL061C Bipolar kinesin motor protein genetic 5 2 3 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 4 3 4 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality
HTZ1 YOL012C Histone variant H2AZ genetic 4 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
CIN2 YPL241C GTPase-activating protein (GAP) for Cin4p genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 4 2 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) genetic 4 3 3 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 4 3 3 Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Synthetic Lethality
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 4 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
TUB4 YLR212C Gamma-tubulin genetic 4 3 3 Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Synthetic Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 4 2 3 Positive Genetic, Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement
DYN2 YDR424C Cytoplasmic light chain dynein, microtubule motor protein genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 4 2 3 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 4 2 2 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
SLI15 YBR156C Subunit of the conserved chromosomal passenger complex (CPC) physical 3 3 3 Two-hybrid, Reconstituted Complex, Affinity Capture-MS
KAR3 YPR141C Minus-end-directed microtubule motor physical 3 3 3 Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
TUB1 YML085C Alpha-tubulin physical 3 2 3 Two-hybrid, Two-hybrid, Reconstituted Complex
TUB3 YML124C Alpha-tubulin genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
ELP2 YGR200C Subunit of Elongator complex genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
RPA14 YDR156W RNA polymerase I subunit A14 genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) physical 3 1 3 Two-hybrid, Two-hybrid, Two-hybrid
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 3 3 2 Synthetic Lethality, Phenotypic Suppression, Positive Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 3 2 2 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
PAN3 YKL025C Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 3 2 2 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 3 2 2 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
ELP3 YPL086C Subunit of Elongator complex genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 3 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
BCH1 YMR237W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 3 2 2 Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement
RAD7 YJR052W Nucleotide excision repair (NER) protein genetic 3 1 2 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TUB1 YML085C Alpha-tubulin genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 2 Synthetic Lethality, Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
CIK1 YMR198W Kinesin-associated protein physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
ELM1 YKL048C Serine/threonine protein kinase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 2 Synthetic Lethality, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
LOS1 YKL205W Nuclear pore protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
PLP1 YDR183W Protein that interacts with CCT (chaperonin containing TCP-1) complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DPH1 YIL103W Protein required for synthesis of diphthamide genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NDL1 YLR254C Homolog of nuclear distribution factor NudE genetic 2 2 2 Synthetic Lethality, Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
INO2 YDR123C Transcription factor genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
BRN1 YBL097W Subunit of the condensin complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 2 2 2 Dosage Rescue, Negative Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
BEM1 YBR200W Protein containing SH3-domains genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 2 1 2 Negative Genetic, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
VAC14 YLR386W Enzyme regulator genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RAD51 YER095W Strand exchange protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 2 Negative Genetic, Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 2 1 2 Negative Genetic, Negative Genetic
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 2 1 2 Negative Genetic, Negative Genetic
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 2 1 2 Negative Genetic, Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 2 1 2 Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Positive Genetic, Positive Genetic
PAN2 YGL094C Catalytic subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex genetic 2 1 2 Negative Genetic, Negative Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 2 1 2 Negative Genetic, Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 2 1 2 Negative Genetic, Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 2 1 2 Positive Genetic, Positive Genetic
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 2 1 2 Negative Genetic, Negative Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 2 1 2 Negative Genetic, Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 2 1 2 Negative Genetic, Negative Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 2 Negative Genetic, Negative Genetic
TIP41 YPR040W Tap42p-interacting protein genetic 2 1 2 Negative Genetic, Negative Genetic
HOS1 YPR068C Class I histone deacetylase (HDAC) family member genetic 2 1 2 Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 2 Negative Genetic, Negative Genetic
AIM4 YBR194W Protein proposed to be associated with the nuclear pore complex genetic 2 1 2 Negative Genetic, Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
KOG1 YHR186C Subunit of TORC1 physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
STH1 YIL126W ATPase component of the RSC chromatin remodeling complex genetic 2 2 1 Dosage Rescue, Synthetic Growth Defect
IKI3 YLR384C Subunit of Elongator complex genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
BNI1 YNL271C Formin genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
ATG26 YLR189C UDP-glucose:sterol glucosyltransferase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
AGX1 YFL030W Alanine:glyoxylate aminotransferase (AGT) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
APE1 YKL103C Vacuolar aminopeptidase yscI genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BUD6 YLR319C Actin- and formin-interacting protein physical 2 1 1 Reconstituted Complex, Reconstituted Complex
BUD6 YLR319C Actin- and formin-interacting protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GOR1 YNL274C Glyoxylate reductase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PUF4 YGL014W Member of the PUF protein family genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
UBP16 YPL072W Deubiquitinating enzyme anchored to the outer mitochondrial membrane genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ERV2 YPR037C Flavin-linked sulfhydryl oxidase localized to the ER lumen genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MIS1 YBR084W Mitochondrial C1-tetrahydrofolate synthase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BZZ1 YHR114W SH3 domain protein implicated in regulating actin polymerization genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RDI1 YDL135C Rho GDP dissociation inhibitor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
NHP6A YPR052C High-mobility group (HMG) protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
DIP5 YPL265W Dicarboxylic amino acid permease genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SDH9 YJL045W Minor succinate dehydrogenase isozyme genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
OSM1 YJR051W Fumarate reductase, catalyzes the reduction of fumarate to succinate genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PAH1 YMR165C Mg2+-dependent phosphatidate (PA) phosphatase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PET8 YNL003C S-adenosylmethionine transporter of the mitochondrial inner membrane genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PUF2 YPR042C PUF family mRNA-binding protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RPL42A YNL162W Ribosomal 60S subunit protein L42A genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YGR017W YGR017W Putative protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YIL092W YIL092W Putative protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YOR283W YOR283W Phosphatase with a broad substrate specificity genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SIM1 YIL123W Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BNR1 YIL159W Formin genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PRM6 YML047C Potassium transporter that mediates K+ influx genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
GUD1 YDL238C Guanine deaminase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
KTR1 YOR099W Alpha-1,2-mannosyltransferase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MDL2 YPL270W Mitochondrial inner membrane half-type ABC transporter genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
SIP3 YNL257C Putative sterol transfer protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
POA1 YBR022W Phosphatase that is highly specific for ADP-ribose 1''-phosphate genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RPL41B YDL133C-A Ribosomal 60S subunit protein L41B genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YLR456W YLR456W Protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YPR196W YPR196W Putative maltose-responsive transcription factor genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YER034W YER034W Protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BUD4 YJR092W Anillin-like protein involved in bud-site selection genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YIL165C YIL165C Putative protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YKR015C YKR015C Putative protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
UTR2 YEL040W Chitin transglycosylase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EMI2 YDR516C Hexokinase expressed during growth with low glucose levels genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MRX11 YPL041C Protein that associates with mitochondrial ribosome genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YRF1-6 YNL339C Helicase encoded by the Y' element of subtelomeric regions genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
FUM1 YPL262W Fumarase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
ECM33 YBR078W GPI-anchored protein involved in efficient glucose uptake genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MRX21 YPR011C Mitochondrial transporter genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YBR238C YBR238C Mitochondrial membrane protein genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YAP1801 YHR161C Protein of the AP180 family, involved in clathrin cage assembly genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
BTT1 YDR252W Heterotrimeric nascent polypeptide-associated complex beta3 subunit genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
EDC2 YER035W RNA-binding protein that directly activates mRNA decapping genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
URK1 YNR012W Uridine/cytidine kinase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YGR283C YGR283C Putative methyltransferase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
NGL3 YML118W 3'-5' exonuclease specific for poly-A RNAs genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
YPL264C YPL264C Endoplasmic reticulum protein of unknown function genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
FPR2 YDR519W Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase) genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
DPH6 YLR143W Diphthamide synthetase genetic 2 1 1 Phenotypic Enhancement, Phenotypic Enhancement
MPS3 YJL019W Nuclear envelope protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Positive Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Negative Genetic
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Synthetic Lethality
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
ASA1 YPR085C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 1 1 1 Positive Genetic
ACS1 YAL054C Acetyl-coA synthetase isoform genetic 1 1 1 Negative Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Positive Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
PRE4 YFR050C Beta 7 subunit of the 20S proteasome physical 1 1 1 Two-hybrid
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
TUB3 YML124C Alpha-tubulin physical 1 1 1 Two-hybrid
SPC110 YDR356W Inner plaque spindle pole body (SPB) component physical 1 1 1 Co-purification
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
RRS1 YOR294W Essential protein that binds ribosomal protein L11 physical 1 1 1 Affinity Capture-MS
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 1 1 1 Affinity Capture-MS
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Negative Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A physical 1 1 1 Affinity Capture-MS
RPL12B YDR418W Ribosomal 60S subunit protein L12B physical 1 1 1 Affinity Capture-MS
RPL22A YLR061W Ribosomal 60S subunit protein L22A physical 1 1 1 Affinity Capture-MS
RPL22A YLR061W Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS25B YLR333C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RTS3 YGR161C Putative component of the protein phosphatase type 2A complex physical 1 1 1 Affinity Capture-MS
SHE1 YBL031W Mitotic spindle protein physical 1 1 1 Two-hybrid
SPC34 YKR037C Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 Two-hybrid
SPC34 YKR037C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Synthetic Lethality
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 1 1 1 Two-hybrid
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Two-hybrid
NFI1 YOR156C SUMO E3 ligase physical 1 1 1 Two-hybrid
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease physical 1 1 1 Two-hybrid
NIS1 YNL078W Protein involved in axial bud site selection physical 1 1 1 Two-hybrid
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 1 1 1 Two-hybrid
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Two-hybrid
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation physical 1 1 1 Two-hybrid
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Negative Genetic
NBL1 YHR199C-A Subunit of the conserved chromosomal passenger complex (CPC) physical 1 1 1 Affinity Capture-MS
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Phenotypic Suppression
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 1 1 1 Affinity Capture-MS
LST8 YNL006W Protein required for the transport of Gap1p physical 1 1 1 Affinity Capture-MS
SLT2 YHR030C Serine/threonine MAP kinase physical 1 1 1 PCA
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Lethality
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Synthetic Lethality
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Lethality
IRC3 YDR332W Double-stranded DNA-dependent helicase of the DExH/D-box family genetic 1 1 1 Synthetic Lethality
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Dosage Rescue
DMA1 YHR115C Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
DMA2 YNL116W Ubiquitin-protein ligase (E3) genetic 1 1 1 Synthetic Lethality
BUD14 YAR014C Protein involved in bud-site selection genetic 1 1 1 Synthetic Growth Defect
BUD25 YER014C-A Protein involved in bud-site selection genetic 1 1 1 Synthetic Lethality
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Synthetic Lethality
CDC26 YFR036W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Synthetic Growth Defect
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Synthetic Lethality
CSM4 YPL200W Protein required for accurate chromosome segregation during meiosis genetic 1 1 1 Synthetic Growth Defect
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Synthetic Growth Defect
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
DOC1 YGL240W Processivity factor genetic 1 1 1 Synthetic Lethality
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Synthetic Growth Defect
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Synthetic Lethality
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Lethality
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 1 1 1 Synthetic Growth Defect
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Synthetic Lethality
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 1 1 1 Synthetic Lethality
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Lethality
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Synthetic Lethality
QRI5 YLR204W Mitochondrial inner membrane protein genetic 1 1 1 Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
RPA12 YJR063W RNA polymerase I subunit A12.2 genetic 1 1 1 Synthetic Growth Defect
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Synthetic Growth Defect
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 1 1 1 Synthetic Growth Defect
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Synthetic Growth Defect
SGO1 YOR073W Component of the spindle checkpoint genetic 1 1 1 Synthetic Lethality
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Lethality
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Synthetic Lethality
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Lethality
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 1 1 1 Synthetic Lethality
YBR284W YBR284W Putative metallo-dependent hydrolase superfamily protein genetic 1 1 1 Synthetic Growth Defect
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Synthetic Lethality
CBF2 YGR140W Essential kinetochore protein genetic 1 1 1 Synthetic Lethality
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Synthetic Growth Defect
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Negative Genetic
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Negative Genetic
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Positive Genetic
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Positive Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Positive Genetic
YCS4 YLR272C Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Synthetic Growth Defect
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
TDA8 YAL064C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
YAR029W YAR029W Member of DUP240 gene family but contains no transmembrane domains genetic 1 1 1 Negative Genetic
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
SCT1 YBL011W Glycerol 3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Negative Genetic
ECM15 YBL001C Non-essential protein of unknown function genetic 1 1 1 Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 1 1 1 Negative Genetic
MGR1 YCL044C Subunit of the mitochondrial (mt) i-AAA protease supercomplex genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
PEX19 YDL065C Chaperone and import receptor for newly-synthesized class I PMPs genetic 1 1 1 Negative Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Negative Genetic
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
MRPL1 YDR116C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Positive Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Positive Genetic
YDR248C YDR248C Putative gluconokinase genetic 1 1 1 Negative Genetic
EXG2 YDR261C Exo-1,3-beta-glucanase genetic 1 1 1 Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Positive Genetic
SIP1 YDR422C One of three alternate beta-subunits of the Snf1p kinase complex genetic 1 1 1 Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
RPL22B YFL034C-A Ribosomal 60S subunit protein L22A genetic 1 1 1 Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 1 1 1 Negative Genetic
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Negative Genetic
CBP4 YGR174C Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
FYV4 YHR059W Protein of unknown function genetic 1 1 1 Negative Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
YJL206C YJL206C Putative protein of unknown function genetic 1 1 1 Positive Genetic
TOH1 YJL171C GPI-anchored cell wall protein of unknown function genetic 1 1 1 Negative Genetic
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Negative Genetic
KHA1 YJL094C Putative K+/H+ antiporter genetic 1 1 1 Negative Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Negative Genetic
MRP49 YKL167C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 1 1 1 Negative Genetic
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
SSK1 YLR006C Cytoplasmic phosphorelay intermediate osmosensor and regulator genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
BMT6 YLR063W Methyltransferase required for m3U2843 methylation of the 25S rRNA genetic 1 1 1 Negative Genetic
YLR152C YLR152C Putative protein of unknown function genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Positive Genetic
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly genetic 1 1 1 Negative Genetic
NUP53 YMR153W FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
CPT1 YNL130C Cholinephosphotransferase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
LAT1 YNL071W Dihydrolipoamide acetyltransferase component (E2) of the PDC genetic 1 1 1 Negative Genetic
RCM1 YNL022C rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Positive Genetic
PUB1 YNL016W Poly (A)+ RNA-binding protein genetic 1 1 1 Negative Genetic
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation genetic 1 1 1 Negative Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Positive Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Positive Genetic
TMC1 YOR052C AN1-type zinc finger protein, effector of proteotoxic stress response genetic 1 1 1 Negative Genetic
TGL5 YOR081C Bifunctional triacylglycerol lipase and LPA acyltransferase genetic 1 1 1 Negative Genetic
PEX27 YOR193W Peripheral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Positive Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 1 1 1 Positive Genetic
RPL21B YPL079W Ribosomal 60S subunit protein L21B genetic 1 1 1 Negative Genetic
PMA2 YPL036W Plasma membrane H+-ATPase genetic 1 1 1 Positive Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
YPR096C YPR096C Protein of unknown function genetic 1 1 1 Negative Genetic
SUE1 YPR151C Protein required for degradation of unstable forms of cytochrome c genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
SHS1 YDL225W Component of the septin ring that is required for cytokinesis genetic 1 1 1 Synthetic Growth Defect
MSN5 YDR335W Karyopherin genetic 1 1 1 Synthetic Growth Defect
UBA4 YHR111W E1-like protein that activates Urm1p before urmylation genetic 1 1 1 Synthetic Growth Defect
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Synthetic Growth Defect
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
CHS7 YHR142W Protein of unknown function genetic 1 1 1 Synthetic Lethality
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Synthetic Lethality
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Synthetic Growth Defect
RER2 YBR002C Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1 genetic 1 1 1 Synthetic Growth Defect
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Synthetic Growth Defect
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
IZH2 YOL002C Plasma membrane receptor for plant antifungal osmotin genetic 1 1 1 Synthetic Growth Defect
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Positive Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Positive Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Positive Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 1 1 1 Positive Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Positive Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 1 1 1 Positive Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Positive Genetic
GAA1 YLR088W Subunit of the GPI:protein transamidase complex genetic 1 1 1 Positive Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Positive Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Positive Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Positive Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Positive Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Positive Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Positive Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 1 1 1 Positive Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Positive Genetic
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Negative Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Negative Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
FAD1 YDL045C Flavin adenine dinucleotide (FAD) synthetase genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Negative Genetic
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
BRR6 YGL247W Essential nuclear envelope integral membrane protein genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
SPC97 YHR172W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Negative Genetic
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SPC98 YNL126W Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex genetic 1 1 1 Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
GPN2 YOR262W Putative GTPase with a specific role in RNA pol II and polIII biogenes genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CBR1 YIL043C Cytochrome b reductase and NADH-dependent reductase for Dph3p genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
COX10 YPL172C Heme A:farnesyltransferase genetic 1 1 1 Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Phenotypic Suppression
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Phenotypic Enhancement
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Rescue
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 1 1 1 Positive Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Positive Genetic
ASE1 YOR058C Mitotic spindle midzone-localized microtubule bundling protein physical 1 1 1 Two-hybrid
ALT1 YLR089C Alanine transaminase (glutamic pyruvic transaminase) genetic 1 1 1 Positive Genetic
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Positive Genetic
AVT5 YBL089W Putative transporter genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Synthetic Lethality