Standard name Systematic name Name description Description
SMT3 YDR510W Ubiquitin-like protein of the SUMO family Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant
Visualize the interactome of SMT3
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.989 0.982 0.976

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 2940

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SMT3 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 11 4 9 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Dosage Rescue, Dosage Growth Defect, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 10 5 7 Two-hybrid, Two-hybrid, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Two-hybrid, Protein-peptide, Reconstituted Complex
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates physical 9 6 7 Co-crystal Structure, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Protein-peptide
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 9 5 7 Two-hybrid, Reconstituted Complex, Co-crystal Structure, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-MS, Biochemical Activity, Reconstituted Complex
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex physical 8 2 8 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Protein-peptide, Two-hybrid
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 8 4 7 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Negative Genetic
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 8 3 5 Biochemical Activity, Protein-peptide, Biochemical Activity, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Protein-peptide, Reconstituted Complex
SIZ1 YDR409W SUMO E3 ligase physical 7 5 6 Two-hybrid, Reconstituted Complex, Two-hybrid, Biochemical Activity, Affinity Capture-MS, Protein-peptide, Reconstituted Complex
ELG1 YOR144C Subunit of an alternative replication factor C complex physical 7 5 5 Affinity Capture-MS, Two-hybrid, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Protein-peptide
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease physical 7 3 5 Two-hybrid, Two-hybrid, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Reconstituted Complex, Biochemical Activity
NSE5 YML023C Component of the SMC5-SMC6 complex physical 5 1 5 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid
CTF4 YPR135W Chromatin-associated protein genetic 5 3 4 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 5 3 4 Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression, Dosage Rescue
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
NIS1 YNL078W Protein involved in axial bud site selection physical 5 2 4 Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex
SLX4 YLR135W Endonuclease involved in processing DNA genetic 5 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 5 4 3 Two-hybrid, Affinity Capture-MS, Two-hybrid, Protein-peptide, Reconstituted Complex
FIR1 YER032W Protein involved in 3' mRNA processing physical 5 4 3 Two-hybrid, Affinity Capture-MS, Two-hybrid, Protein-peptide, Reconstituted Complex
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 4 3 4 Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Synthetic Rescue
NFI1 YOR156C SUMO E3 ligase physical 4 3 4 Two-hybrid, Affinity Capture-MS, Two-hybrid, Protein-peptide
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 4 4 3 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 4 3 3 Protein-peptide, Two-hybrid, Two-hybrid, Affinity Capture-Western
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 4 2 3 Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
SLX1 YBR228W Endonuclease involved in DNA recombination and repair genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 4 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 3 3 3 Affinity Capture-MS, Biochemical Activity, Two-hybrid
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 3 3 3 Affinity Capture-MS, Two-hybrid, PCA
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Dosage Rescue
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex physical 3 3 3 Two-hybrid, Protein-peptide, Reconstituted Complex
ASF1 YJL115W Nucleosome assembly factor genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 3 2 3 Affinity Capture-MS, Two-hybrid, Two-hybrid
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 3 3 2 Affinity Capture-MS, PCA, Affinity Capture-Western
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 3 3 2 Affinity Capture-MS, PCA, Affinity Capture-Western
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SAP1 YER047C Putative ATPase of the AAA family physical 3 2 2 Two-hybrid, Affinity Capture-MS, Two-hybrid
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein physical 3 2 2 Two-hybrid, Affinity Capture-Western, Two-hybrid
RAD52 YML032C Protein involved in homologous recombination genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 2 2 Dosage Rescue, Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SRL2 YLR082C Protein of unknown function genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM11 YDR446W Meiosis-specific protein physical 3 1 2 Two-hybrid, Two-hybrid, Two-hybrid
RAD18 YCR066W E3 ubiquitin ligase physical 3 2 1 Two-hybrid, Two-hybrid, Reconstituted Complex
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
FKH2 YNL068C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CDC73 YLR418C Component of the Paf1p complex genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 2 2 2 Phenotypic Suppression, Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins physical 2 2 2 Affinity Capture-MS, Two-hybrid
AIR2 YDL175C RNA-binding subunit of the TRAMP nuclear RNA surveillance complex genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 2 2 2 Affinity Capture-MS, Two-hybrid
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 2 2 2 Affinity Capture-MS, Biochemical Activity
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 2 2 Negative Genetic, Positive Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 2 2 2 Affinity Capture-MS, Two-hybrid
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination physical 2 2 2 Affinity Capture-Western, Two-hybrid
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A physical 2 2 2 Affinity Capture-MS, PCA
RPC53 YDL150W RNA polymerase III subunit C53 physical 2 2 2 Affinity Capture-MS, PCA
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 2 2 2 Dosage Rescue, Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 2 2 2 Affinity Capture-MS, Two-hybrid
HIR3 YJR140C Subunit of the HIR complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
KAP122 YGL016W Karyopherin beta genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 2 2 2 Affinity Capture-MS, Biochemical Activity
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 2 2 2 Affinity Capture-MS, Two-hybrid
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NMA1 YLR328W Nicotinic acid mononucleotide adenylyltransferase physical 2 2 2 Affinity Capture-MS, Two-hybrid
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 2 2 Affinity Capture-MS, Reconstituted Complex
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 2 2 2 Affinity Capture-MS, PCA
TOP2 YNL088W Topoisomerase II physical 2 2 2 Affinity Capture-MS, Two-hybrid
TRI1 YMR233W Non-essential sumoylated protein of unknown function physical 2 2 2 Affinity Capture-MS, Two-hybrid
TFA2 YKR062W TFIIE small subunit physical 2 2 2 Affinity Capture-MS, PCA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 2 2 2 Affinity Capture-MS, Affinity Capture-RNA
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 2 2 2 Affinity Capture-MS, Two-hybrid
TRP5 YGL026C Tryptophan synthase physical 2 2 2 Affinity Capture-MS, Two-hybrid
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 PCA, Affinity Capture-MS
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
YLR287C YLR287C Putative protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 2 2 2 Phenotypic Suppression, Positive Genetic
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 2 2 2 Affinity Capture-MS, Two-hybrid
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RIF1 YBR275C Protein involved in control of DNA replication genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 2 2 Synthetic Rescue, Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 2 2 2 Affinity Capture-MS, Two-hybrid
ESC1 YMR219W Protein involved in telomeric silencing genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC19 YAL038W Pyruvate kinase physical 2 2 2 Affinity Capture-MS, PCA
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia physical 2 2 2 Affinity Capture-MS, Two-hybrid
BOP3 YNL042W Protein of unknown function physical 2 2 2 Affinity Capture-MS, Two-hybrid
ORM2 YLR350W Protein that mediates sphingolipid homeostasis physical 2 2 2 Affinity Capture-MS, Two-hybrid
EUC1 YMR111C Sequence-specific DNA binding protein physical 2 2 2 Affinity Capture-MS, Two-hybrid
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BIO2 YGR286C Biotin synthase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PIN2 YOR104W Exomer-dependent cargo protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NPR3 YHL023C Subunit of the Iml1p/SEACIT complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RTC2 YBR147W Putative vacuolar membrane transporter for cationic amino acids genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex physical 2 1 2 Biochemical Activity, Biochemical Activity
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 2 1 2 Positive Genetic, Positive Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RED1 YLR263W Protein component of the synaptonemal complex axial elements physical 2 1 2 Two-hybrid, Two-hybrid
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 2 1 2 Negative Genetic, Negative Genetic
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I physical 2 1 2 Two-hybrid, Two-hybrid
SRP1 YNL189W Karyopherin alpha homolog physical 2 1 2 Two-hybrid, Two-hybrid
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 2 1 2 Two-hybrid, Two-hybrid
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 2 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 2 Negative Genetic, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 1 2 Negative Genetic, Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RTT109 YLL002W Histone acetyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
PHD1 YKL043W Transcriptional activator that enhances pseudohyphal growth physical 2 1 2 Two-hybrid, Two-hybrid
LDB16 YCL005W Protein involved in lipid droplet (LD) assembly genetic 2 1 2 Negative Genetic, Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 2 2 1 PCA, Affinity Capture-Western
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family physical 2 2 1 PCA, Affinity Capture-Western
KAP95 YLR347C Karyopherin beta genetic 2 2 1 Positive Genetic, Negative Genetic
RCL1 YOL010W Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis physical 2 2 1 PCA, Affinity Capture-Western
CYS4 YGR155W Cystathionine beta-synthase physical 2 2 1 PCA, Affinity Capture-Western
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 2 2 1 PCA, Affinity Capture-Western
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 2 2 1 PCA, Affinity Capture-Western
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex physical 2 2 1 Two-hybrid, Reconstituted Complex
THR1 YHR025W Homoserine kinase physical 2 2 1 PCA, Affinity Capture-Western
TMA22 YJR014W Protein of unknown function physical 2 2 1 PCA, Affinity Capture-Western
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family physical 2 2 1 Two-hybrid, Reconstituted Complex
TUB1 YML085C Alpha-tubulin physical 2 2 1 Reconstituted Complex, Two-hybrid
CST9 YLR394W SUMO E3 ligase physical 2 2 1 Two-hybrid, Biochemical Activity
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 2 2 1 PCA, Affinity Capture-Western
PDS5 YMR076C Cohesion maintenance factor genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
CWP2 YKL096W-A Covalently linked cell wall mannoprotein physical 2 2 1 PCA, Affinity Capture-Western
ILM1 YJR118C Protein of unknown function genetic 2 2 1 Positive Genetic, Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 2 1 1 Negative Genetic, Negative Genetic
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 1 1 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 1 1 Negative Genetic, Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 2 1 1 Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 2 1 1 Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 2 1 1 Negative Genetic, Negative Genetic
NUP145 YGL092W Essential protein with distinct roles in two nuclear pore subcomplexes genetic 2 1 1 Negative Genetic, Negative Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 2 1 1 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p genetic 2 1 1 Negative Genetic, Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 2 1 1 Negative Genetic, Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
UTP9 YHR196W Nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 2 1 1 Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 1 Negative Genetic, Negative Genetic
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 2 1 1 Negative Genetic, Negative Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 2 1 1 Positive Genetic, Positive Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET32 YDR253C Zinc-finger DNA-binding transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MET4 YNL103W Leucine-zipper transcriptional activator regulation 1 1 1 chromatin immunoprecipitation-chip evidence
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif regulation 1 1 1 DNA to cDNA expression microarray evidence
XBP1 YIL101C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 DNA to cDNA expression microarray evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NRG1 YDR043C Transcriptional repressor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation physical 1 1 1 PCA
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Synthetic Growth Defect
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 PCA
BFR2 YDR299W Component of the SSU and 90S preribosomes physical 1 1 1 PCA
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 PCA
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing physical 1 1 1 Affinity Capture-MS
NIP7 YPL211W Nucleolar protein required for 60S ribosome subunit biogenesis physical 1 1 1 PCA
RPL32 YBL092W Ribosomal 60S subunit protein L32 physical 1 1 1 Affinity Capture-MS
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Affinity Capture-MS
KAP123 YER110C Karyopherin beta genetic 1 1 1 Negative Genetic
MIA40 YKL195W Import and assembly protein in mitochondrial intermembrane space genetic 1 1 1 Positive Genetic
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
KRE29 YER038C Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NOC2 YOR206W Protein involved in ribosome biogenesis physical 1 1 1 PCA
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes physical 1 1 1 PCA
DIP2 YLR129W Nucleolar protein genetic 1 1 1 Negative Genetic
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 PCA
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
GAR1 YHR089C Protein component of the H/ACA snoRNP pseudouridylase complex physical 1 1 1 PCA
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein physical 1 1 1 PCA
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles physical 1 1 1 PCA
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 PCA
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Negative Genetic
ALB1 YJL122W Shuttling pre-60S factor physical 1 1 1 PCA
HCA4 YJL033W DEAD box RNA helicase physical 1 1 1 PCA
MTR4 YJL050W RNA duplex-sensing translocase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RPS4B YHR203C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
IML1 YJR138W GTPase-activating protein (GAP) subunit of the Iml1p/SEACIT complex genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
RPC19 YNL113W RNA polymerase subunit AC19 genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-MS
RPB7 YDR404C RNA polymerase II subunit B16 physical 1 1 1 PCA
RPL3 YOR063W Ribosomal 60S subunit protein L3 physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 PCA
RSC58 YLR033W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC9 YML127W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase physical 1 1 1 PCA
DST1 YGL043W General transcription elongation factor TFIIS physical 1 1 1 PCA
PWP1 YLR196W Protein with WD-40 repeats involved in rRNA processing genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Negative Genetic
CDC39 YCR093W Subunit of the CCR4-NOT1 core complex genetic 1 1 1 Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
LHP1 YDL051W RNA binding protein required for maturation of tRNA and U6 snRNA physical 1 1 1 Affinity Capture-MS
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
AOS1 YPR180W Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Uba2p genetic 1 1 1 Negative Genetic
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome genetic 1 1 1 Positive Genetic
ASF1 YJL115W Nucleosome assembly factor physical 1 1 1 Affinity Capture-MS
BEM2 YER155C Rho GTPase activating protein (RhoGAP) physical 1 1 1 Affinity Capture-MS
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Positive Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex physical 1 1 1 Two-hybrid
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Positive Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Dosage Growth Defect
CYR1 YJL005W Adenylate cyclase physical 1 1 1 Affinity Capture-MS
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation physical 1 1 1 Reconstituted Complex
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase physical 1 1 1 Affinity Capture-MS
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
HRP1 YOL123W Subunit of cleavage factor I physical 1 1 1 Affinity Capture-MS
HRP1 YOL123W Subunit of cleavage factor I genetic 1 1 1 Negative Genetic
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 1 1 1 Synthetic Growth Defect
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) genetic 1 1 1 Negative Genetic
IOC3 YFR013W Subunit of the Isw1a complex genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-MS
KGD2 YDR148C Dihydrolipoyl transsuccinylase physical 1 1 1 Two-hybrid
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor physical 1 1 1 Affinity Capture-MS
MRD1 YPR112C Essential conserved small ribosomal subunit (40s) synthesis factor genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase physical 1 1 1 Affinity Capture-MS
MRP7 YNL005C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Positive Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Synthetic Rescue
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 1 1 1 Protein-peptide
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
HTZ1 YOL012C Histone variant H2AZ physical 1 1 1 PCA
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
FPR4 YLR449W Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
FAS2 YPL231W Alpha subunit of fatty acid synthetase physical 1 1 1 PCA
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 PCA
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Negative Genetic
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Negative Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
MRPL38 YKL170W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
PAA1 YDR071C Polyamine acetyltransferase physical 1 1 1 Affinity Capture-MS
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Two-hybrid
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
NOC4 YPR144C Nucleolar protein physical 1 1 1 PCA
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 1 1 1 Affinity Capture-MS
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 1 1 1 Affinity Capture-MS
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Protein-peptide
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC3 YNL290W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 PCA
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RPB8 YOR224C RNA polymerase subunit ABC14.5 genetic 1 1 1 Negative Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Positive Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 1 1 1 Negative Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 PCA
IST2 YBR086C Cortical ER protein involved in ER-plasma membrane (PM) tethering physical 1 1 1 Affinity Capture-MS
HEM13 YDR044W Coproporphyrinogen III oxidase genetic 1 1 1 Negative Genetic
DAL3 YIR032C Ureidoglycolate lyase genetic 1 1 1 Synthetic Growth Defect
SEC3 YER008C Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Positive Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex physical 1 1 1 Affinity Capture-MS
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Negative Genetic
RIO2 YNL207W Essential serine kinase involved in the processing of 20S pre-rRNA genetic 1 1 1 Negative Genetic
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
FPR3 YML074C Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes physical 1 1 1 Affinity Capture-MS
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Synthetic Growth Defect
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Affinity Capture-MS
RTK1 YDL025C Putative protein kinase, potentially phosphorylated by Cdc28p physical 1 1 1 Affinity Capture-MS
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
GSP1 YLR293C Ran GTPase genetic 1 1 1 Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Reconstituted Complex
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 1 1 1 Negative Genetic
ARO4 YBR249C 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase physical 1 1 1 Two-hybrid
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) physical 1 1 1 PCA
NOP6 YDL213C rRNA-binding protein required for 40S ribosomal subunit biogenesis genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Two-hybrid
CMK1 YFR014C Calmodulin-dependent protein kinase genetic 1 1 1 Synthetic Growth Defect
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 1 1 1 Negative Genetic
ADK1 YDR226W Adenylate kinase, required for purine metabolism physical 1 1 1 Affinity Capture-MS
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
CYC8 YBR112C General transcriptional co-repressor physical 1 1 1 PCA
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) physical 1 1 1 Affinity Capture-MS
MRS6 YOR370C Rab escort protein genetic 1 1 1 Positive Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Synthetic Growth Defect
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis physical 1 1 1 Affinity Capture-MS
SMC6 YLR383W Subunit of the SMC5-SMC6 complex physical 1 1 1 Affinity Capture-MS
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Negative Genetic
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Negative Genetic
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Synthetic Growth Defect
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
KEL2 YGR238C Protein that negatively regulates mitotic exit genetic 1 1 1 Synthetic Growth Defect
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 PCA
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 1 1 1 Protein-peptide
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair physical 1 1 1 Protein-peptide
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase physical 1 1 1 Affinity Capture-MS
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 1 1 1 Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Positive Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase physical 1 1 1 PCA
PMI40 YER003C Mannose-6-phosphate isomerase physical 1 1 1 Affinity Capture-MS
ADE6 YGR061C Formylglycinamidine-ribonucleotide (FGAM)-synthetase physical 1 1 1 Affinity Capture-MS
NTA1 YJR062C Amidase genetic 1 1 1 Synthetic Growth Defect
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 1 1 1 Phenotypic Suppression
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) physical 1 1 1 Protein-peptide
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Synthetic Growth Defect
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) physical 1 1 1 PCA
BIM1 YER016W Microtubule plus end-tracking protein physical 1 1 1 Two-hybrid
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 1 1 1 Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
TOP1 YOL006C Topoisomerase I physical 1 1 1 Affinity Capture-MS
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-MS
SPA2 YLL021W Component of the polarisome physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
STB3 YDR169C Ribosomal RNA processing element (RRPE)-binding protein physical 1 1 1 Affinity Capture-MS
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Affinity Capture-MS
TUP1 YCR084C General repressor of transcription in complex with Cyc8p physical 1 1 1 Affinity Capture-MS
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes physical 1 1 1 Affinity Capture-MS
SNF1 YDR477W AMP-activated S/T protein kinase physical 1 1 1 Affinity Capture-MS
YBL005W-B YBL005W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
YSH1 YLR277C Endoribonuclease physical 1 1 1 Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 1 1 1 Affinity Capture-MS
TKL1 YPR074C Transketolase physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme physical 1 1 1 Affinity Capture-MS
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p physical 1 1 1 Affinity Capture-MS
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase physical 1 1 1 Affinity Capture-MS
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers physical 1 1 1 Affinity Capture-MS
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis physical 1 1 1 Affinity Capture-MS
YAR010C YAR010C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Affinity Capture-MS
ZEO1 YOL109W Peripheral membrane protein of the plasma membrane physical 1 1 1 Affinity Capture-MS
YCR016W YCR016W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
YBR238C YBR238C Mitochondrial membrane protein physical 1 1 1 Affinity Capture-MS
TUM1 YOR251C Rhodanese domain sulfur transferase physical 1 1 1 Affinity Capture-MS
YLL032C YLL032C Protein of unknown function physical 1 1 1 Affinity Capture-MS
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Dosage Rescue
YCL020W YCL020W Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Two-hybrid
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Negative Genetic
UBX5 YDR330W UBX domain-containing protein that interacts with Cdc48p physical 1 1 1 Two-hybrid
UBX5 YDR330W UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Synthetic Growth Defect
TRP3 YKL211C Indole-3-glycerol-phosphate synthase physical 1 1 1 Two-hybrid
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes physical 1 1 1 Two-hybrid
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Protein-peptide
URN1 YPR152C Protein of unknown function containing WW and FF domains physical 1 1 1 Protein-peptide
SPT5 YML010W Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 PCA
TRM1 YDR120C tRNA methyltransferase physical 1 1 1 PCA
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B physical 1 1 1 PCA
SRP40 YKR092C Nucleolar serine-rich protein physical 1 1 1 PCA
TIF1 YKR059W Translation initiation factor eIF4A physical 1 1 1 PCA
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit physical 1 1 1 PCA
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 PCA
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 1 1 1 PCA
SPT21 YMR179W Protein with a role in transcriptional silencing physical 1 1 1 Affinity Capture-MS
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 1 1 1 Protein-peptide
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p physical 1 1 1 Protein-peptide
UBA2 YDR390C Subunit of heterodimeric nuclear SUMO activating enzyme E1 with Aos1p genetic 1 1 1 Synthetic Rescue
XRS2 YDR369C FHA domain-containing component of the Mre11 complex physical 1 1 1 Protein-peptide
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
YEN1 YER041W Holliday junction resolvase physical 1 1 1 Two-hybrid
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 1 1 1 Positive Genetic
TIR3 YIL011W Cell wall mannoprotein genetic 1 1 1 Negative Genetic
YJR120W YJR120W Protein of unknown function genetic 1 1 1 Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 1 1 1 Negative Genetic
TTI1 YKL033W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Positive Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Synthetic Growth Defect
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Synthetic Growth Defect
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Synthetic Growth Defect
YOX1 YML027W Homeobox transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
YPR172W YPR172W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SOK1 YDR006C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YLR278C YLR278C Zinc-cluster protein genetic 1 1 1 Synthetic Growth Defect
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Synthetic Growth Defect
YOL153C YOL153C Blocked reading frame, contains two in-frame stops in translation genetic 1 1 1 Synthetic Growth Defect
YAR028W YAR028W Putative integral membrane protein genetic 1 1 1 Synthetic Growth Defect
VPS62 YGR141W Vacuolar protein sorting (VPS) protein genetic 1 1 1 Synthetic Growth Defect
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Synthetic Growth Defect
VLD1 YIR014W Component of Dsc E3 ligase complex in vacuolar membranes genetic 1 1 1 Synthetic Growth Defect
YFR018C YFR018C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YPL068C YPL068C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SRP102 YKL154W Signal recognition particle (SRP) receptor beta subunit genetic 1 1 1 Positive Genetic
THI80 YOR143C Thiamine pyrophosphokinase genetic 1 1 1 Positive Genetic
YHB1 YGR234W Nitric oxide oxidoreductase genetic 1 1 1 Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Positive Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
YRB1 YDR002W Ran GTPase binding protein genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 1 1 1 Negative Genetic
UTP7 YER082C Nucleolar protein genetic 1 1 1 Negative Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Negative Genetic
UBA1 YKL210W Ubiquitin activating enzyme (E1) genetic 1 1 1 Negative Genetic
YTM1 YOR272W Ribosomal assembly factor and 66S pre-ribosomal particle constituent genetic 1 1 1 Negative Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
TDA8 YAL064C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
YBL071C-B YBL071C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
SRO77 YBL106C Protein with roles in exocytosis and cation homeostasis genetic 1 1 1 Negative Genetic
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
YCL001W-A YCL001W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YCR023C YCR023C Vacuolar membrane protein of unknown function genetic 1 1 1 Negative Genetic
YCR024C-B YCR024C-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDL211C YDL211C Protein of unknown function genetic 1 1 1 Negative Genetic
YEL077C YEL077C Helicase-like protein encoded within the telomeric Y' element genetic 1 1 1 Negative Genetic
YER076C YER076C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TYW3 YGL050W tRNA methyltransferase required for synthesis of wybutosine genetic 1 1 1 Negative Genetic
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Negative Genetic
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme genetic 1 1 1 Negative Genetic
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
YIL014C-A YIL014C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJL077W-B YJL077W-B Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJL136W-A YJL136W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
TDA9 YML081W Transcription factor that regulates acetate production genetic 1 1 1 Negative Genetic
YMR155W YMR155W Putative protein of unknown function genetic 1 1 1 Negative Genetic
SPG5 YMR191W Protein required for proteasome assembly during quiescence genetic 1 1 1 Negative Genetic
YMR315W-A YMR315W-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNL018C YNL018C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOS7 YOL019W Protein involved in secretion and cell wall organization genetic 1 1 1 Negative Genetic
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Negative Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SPO23 YBR250W Protein of unknown function genetic 1 1 1 Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 1 1 1 Positive Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 1 1 1 Synthetic Growth Defect
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex physical 1 1 1 PCA
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Negative Genetic
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation physical 1 1 1 Protein-peptide
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
IBD2 YNL164C Component of the BUB2-dependent spindle checkpoint pathway genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
GIP3 YPL137C Cytoplasmic protein that regulates protein phosphatase 1 Glc7p genetic 1 1 1 Synthetic Growth Defect
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Synthetic Growth Defect
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family physical 1 1 1 Affinity Capture-MS
RPL9A YGL147C Ribosomal 60S subunit protein L9A physical 1 1 1 PCA
RPL9A YGL147C Ribosomal 60S subunit protein L9A genetic 1 1 1 Negative Genetic
RPS24A YER074W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping physical 1 1 1 Affinity Capture-MS
SMC2 YFR031C Subunit of the condensin complex genetic 1 1 1 Negative Genetic
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family physical 1 1 1 Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
HOS3 YPL116W Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) genetic 1 1 1 Synthetic Growth Defect
HPC2 YBR215W Subunit of the HIR complex physical 1 1 1 Affinity Capture-MS
RPS1A YLR441C Ribosomal protein of the small (40S) subunit genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 PCA
RPS1B YML063W Ribosomal protein of the small (40S) subunit physical 1 1 1 PCA
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL22A YLR061W Ribosomal 60S subunit protein L22A physical 1 1 1 PCA
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-Western
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 1 1 1 Negative Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Negative Genetic
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 1 1 1 Negative Genetic
KAR9 YPL269W Spindle positioning factor physical 1 1 1 Two-hybrid
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Negative Genetic
BIK1 YCL029C Microtubule-associated protein physical 1 1 1 Two-hybrid
CBF2 YGR140W Essential kinetochore protein physical 1 1 1 Two-hybrid
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci physical 1 1 1 Affinity Capture-MS
SKN7 YHR206W Nuclear response regulator and transcription factor physical 1 1 1 Affinity Capture-MS
SMC4 YLR086W Subunit of the condensin complex physical 1 1 1 Affinity Capture-MS
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
MBF1 YOR298C-A Transcriptional coactivator genetic 1 1 1 Synthetic Growth Defect
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
SLN1 YIL147C Transmembrane histidine phosphotransfer kinase and osmosensor genetic 1 1 1 Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 1 1 1 Synthetic Growth Defect
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity physical 1 1 1 Affinity Capture-MS
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Positive Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
NUP100 YKL068W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Growth Defect
ARG80 YMR042W Transcription factor involved in regulating arginine-responsive genes genetic 1 1 1 Negative Genetic
CHS3 YBR023C Chitin synthase III genetic 1 1 1 Synthetic Growth Defect
ESC2 YDR363W Sumo-like domain protein physical 1 1 1 Two-hybrid
BPT1 YLL015W ABC type transmembrane transporter of MRP/CFTR family genetic 1 1 1 Negative Genetic
PET494 YNR045W Mitochondrial translational activator specific for the COX3 mRNA genetic 1 1 1 Positive Genetic
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p genetic 1 1 1 Negative Genetic
PRP22 YER013W DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-MS
FUS1 YCL027W Membrane protein localized to the shmoo tip genetic 1 1 1 Synthetic Growth Defect
HMS1 YOR032C bHLH protein with similarity to myc-family transcription factors physical 1 1 1 Two-hybrid
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p physical 1 1 1 Reconstituted Complex
PBI2 YNL015W Cytosolic inhibitor of vacuolar proteinase B (PRB1) physical 1 1 1 Affinity Capture-MS
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 1 1 1 Synthetic Growth Defect
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Positive Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A physical 1 1 1 PCA
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 physical 1 1 1 Affinity Capture-MS
RPL18B YNL301C Ribosomal 60S subunit protein L18B physical 1 1 1 Affinity Capture-MS
LEU1 YGL009C Isopropylmalate isomerase physical 1 1 1 Affinity Capture-MS
PER33 YLR064W Protein that localizes to the endoplasmic reticulum genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p physical 1 1 1 Affinity Capture-MS
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Negative Genetic
RPL14B YHL001W Ribosomal 60S subunit protein L14B physical 1 1 1 PCA
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A physical 1 1 1 Affinity Capture-MS
RPL19B YBL027W Ribosomal 60S subunit protein L19B physical 1 1 1 Affinity Capture-MS
RPL21A YBR191W Ribosomal 60S subunit protein L21A physical 1 1 1 Affinity Capture-MS
RPL27B YDR471W Ribosomal 60S subunit protein L27B physical 1 1 1 Affinity Capture-MS
RPL29 YFR032C-A Ribosomal 60S subunit protein L29 physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PET127 YOR017W Protein with a role in 5'-end processing of mitochondrial RNAs physical 1 1 1 Affinity Capture-MS
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane physical 1 1 1 Affinity Capture-MS
LYS21 YDL131W Homocitrate synthase isozyme physical 1 1 1 Affinity Capture-MS
MMT2 YPL224C Putative metal transporter involved in mitochondrial iron accumulation physical 1 1 1 Affinity Capture-MS
PGU1 YJR153W Endo-polygalacturonase physical 1 1 1 Affinity Capture-MS
ASN2 YGR124W Asparagine synthetase physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
MHP1 YJL042W Microtubule-associated protein involved in microtubule organization physical 1 1 1 Affinity Capture-MS
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Negative Genetic
SBE22 YHR103W Protein involved in bud growth physical 1 1 1 Affinity Capture-MS
MIT1 YEL007W Transcriptional regulator of pseudohyphal growth physical 1 1 1 Affinity Capture-MS
AIM44 YPL158C Regulator of Cdc42p and Rho1p physical 1 1 1 Affinity Capture-MS
PAC1 YOR269W Regulator of dynein, involved in intracellular transport physical 1 1 1 Two-hybrid
RPL36B YPL249C-A Ribosomal 60S subunit protein L36B physical 1 1 1 PCA
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
MIG3 YER028C Transcriptional regulator genetic 1 1 1 Negative Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Dosage Rescue
RPL40B YKR094C Ubiquitin-ribosomal 60S subunit protein L40B fusion protein physical 1 1 1 PCA
ATP14 YLR295C Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Two-hybrid
HSP12 YFL014W Plasma membrane protein involved in maintaining membrane organization genetic 1 1 1 Negative Genetic
PHO11 YAR071W One of three repressible acid phosphatases genetic 1 1 1 Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 1 1 1 Negative Genetic
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
NSI1 YDR026C RNA polymerase I termination factor genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Positive Genetic
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase genetic 1 1 1 Negative Genetic
MET12 YPL023C Protein with MTHFR activity in vitro genetic 1 1 1 Synthetic Growth Defect
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 1 1 1 Synthetic Growth Defect
IRC3 YDR332W Double-stranded DNA-dependent helicase of the DExH/D-box family genetic 1 1 1 Synthetic Growth Defect
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
RRP15 YPR143W Nucleolar protein physical 1 1 1 PCA
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Negative Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase genetic 1 1 1 Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A physical 1 1 1 PCA
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 1 1 1 Synthetic Growth Defect
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Synthetic Growth Defect
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
SMT1 YJL147C Translational repressor of the mitochondrial ATP6/8 mRNA genetic 1 1 1 Negative Genetic
ATG33 YLR356W Mitochondrial mitophagy-specific protein genetic 1 1 1 Negative Genetic
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Positive Genetic
DIN7 YDR263C Mitochondrial nuclease functioning in DNA repair and replication genetic 1 1 1 Synthetic Growth Defect
RPL42A YNL162W Ribosomal 60S subunit protein L42A physical 1 1 1 PCA
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Synthetic Growth Defect
HEM12 YDR047W Uroporphyrinogen decarboxylase genetic 1 1 1 Negative Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A physical 1 1 1 PCA
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 1 1 1 Synthetic Growth Defect
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 Two-hybrid
RPL24A YGL031C Ribosomal 60S subunit protein L24A physical 1 1 1 PCA
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 PCA
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RPS21A YKR057W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
MIL1 YFL034W Predicted lipase genetic 1 1 1 Negative Genetic
RPP2A YOL039W Ribosomal protein P2 alpha physical 1 1 1 PCA
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase genetic 1 1 1 Negative Genetic
AZR1 YGR224W Plasma membrane transporter of the major facilitator superfamily genetic 1 1 1 Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RPL26B YGR034W Ribosomal 60S subunit protein L26B physical 1 1 1 PCA
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Positive Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Negative Genetic
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Positive Genetic
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis genetic 1 1 1 Negative Genetic
PAU8 YAL068C Protein of unknown function genetic 1 1 1 Negative Genetic
RUD3 YOR216C Golgi matrix protein genetic 1 1 1 Positive Genetic
PYP1 YNL010W Sugar alcohol phosphatase genetic 1 1 1 Negative Genetic
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Negative Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RKI1 YOR095C Ribose-5-phosphate ketol-isomerase genetic 1 1 1 Negative Genetic
OM14 YBR230C Mitochondrial outer membrane receptor for cytosolic ribosomes physical 1 1 1 PCA
ASI1 YMR119W Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
APE4 YHR113W Cytoplasmic aspartyl aminopeptidase with possible vacuole function genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
PNP1 YLR209C Purine nucleoside phosphorylase genetic 1 1 1 Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 1 1 1 Negative Genetic
BSC1 YDL037C Protein of unconfirmed function genetic 1 1 1 Synthetic Growth Defect
RRT14 YIL127C Putative protein of unknown function genetic 1 1 1 Negative Genetic
HNT2 YDR305C Dinucleoside triphosphate hydrolase genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Positive Genetic
MRN1 YPL184C RNA-binding protein that may be involved in translational regulation genetic 1 1 1 Negative Genetic
RMR1 YGL250W Protein required for meiotic recombination and gene conversion physical 1 1 1 Two-hybrid
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Positive Genetic
LCB3 YJL134W Long-chain base-1-phosphate phosphatase genetic 1 1 1 Synthetic Growth Defect
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
NCS2 YNL119W Protein required for uridine thiolation of Lys(UUU) and Glu(UUC) tRNAs genetic 1 1 1 Negative Genetic
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 PCA
RPL12B YDR418W Ribosomal 60S subunit protein L12B physical 1 1 1 PCA
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MIX23 YBL107C Mitochondrial intermembrane space protein of unknown function genetic 1 1 1 Synthetic Growth Defect
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Negative Genetic
IRC20 YLR247C E3 ubiquitin ligase and putative helicase physical 1 1 1 Affinity Capture-MS
MIC10 YCL057C-A Conserved component of the MICOS complex genetic 1 1 1 Negative Genetic
GSH2 YOL049W Glutathione synthetase genetic 1 1 1 Synthetic Growth Defect
ICY1 YMR195W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RPL24B YGR148C Ribosomal 60S subunit protein L24B physical 1 1 1 PCA
NGL1 YOL042W Putative endonuclease genetic 1 1 1 Synthetic Growth Defect
HST2 YPL015C Cytoplasmic NAD(+)-dependent protein deacetylase genetic 1 1 1 Negative Genetic
RPL41B YDL133C-A Ribosomal 60S subunit protein L41B physical 1 1 1 PCA
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
RPS29A YLR388W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
PUT2 YHR037W Delta-1-pyrroline-5-carboxylate dehydrogenase genetic 1 1 1 Synthetic Growth Defect
SEG2 YKL105C Eisosome component genetic 1 1 1 Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit physical 1 1 1 PCA
REX3 YLR107W RNA exonuclease genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Positive Genetic
DML1 YMR211W Essential protein involved in mtDNA inheritance genetic 1 1 1 Negative Genetic
MNC1 YBR056W-A Putative membrane protein upregulated in toxic manganese levels genetic 1 1 1 Negative Genetic
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
PUS2 YGL063W Mitochondrial tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
SFG1 YOR315W Nuclear protein putative transcription factor genetic 1 1 1 Synthetic Growth Defect
MAN2 YNR073C Mannitol dehydrogenase genetic 1 1 1 Negative Genetic