GEnome-wide tool for Multi-scale Modeling
data Extraction and Representation
for Saccharomyces cerevisiae

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.

Standard name	Systematic name	Name description	Type	#Experiments	#Methods	#Publications	Evidence
PTC1	YDL006W	Type 2C protein phosphatase (PP2C)	physical	11	4	7	Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, PCA, Two-hybrid, PCA, PCA, Affinity Capture-Western
BCK1	YJL095W	MAPKKK acting in the protein kinase C signaling pathway	genetic	10	3	8	Positive Genetic, Positive Genetic, Positive Genetic, Dosage Growth Defect, Synthetic Growth Defect, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
SLT2	YHR030C	Serine/threonine MAP kinase	genetic	9	3	8	Positive Genetic, Positive Genetic, Positive Genetic, Dosage Lethality, Synthetic Growth Defect, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
PBS2	YJL128C	MAP kinase kinase of the HOG signaling pathway	physical	9	6	6	Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Two-hybrid, PCA, PCA, Reconstituted Complex, Protein-peptide
SMI1	YGR229C	Protein involved in the regulation of cell wall synthesis	genetic	9	3	6	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
HSL1	YKL101W	Nim1p-related protein kinase	genetic	9	1	6	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
STE20	YHL007C	Cdc42p-activated signal transducing kinase	physical	8	6	5	Two-hybrid, Affinity Capture-Western, Two-hybrid, PCA, Reconstituted Complex, Protein-peptide, Co-crystal Structure, Protein-peptide
BCK1	YJL095W	MAPKKK acting in the protein kinase C signaling pathway	physical	7	5	5	Affinity Capture-MS, PCA, PCA, Reconstituted Complex, Protein-peptide, Protein-peptide, Affinity Capture-Western
BNI1	YNL271C	Formin	genetic	7	3	5	Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
GAS1	YMR307W	Beta-1,3-glucanosyltransferase required for cell wall assembly	genetic	7	2	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GYP1	YOR070C	Cis-golgi GTPase-activating protein (GAP) for yeast Rabs	genetic	7	2	5	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
OST3	YOR085W	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	7	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CLA4	YNL298W	Cdc42p-activated signal transducing kinase	physical	6	5	5	Two-hybrid, Affinity Capture-MS, PCA, Reconstituted Complex, Protein-peptide, Protein-peptide
YPT6	YLR262C	Rab family GTPase	genetic	6	3	5	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARL1	YBR164C	Soluble GTPase with a role in regulation of membrane traffic	genetic	6	2	5	Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUD14	YAR014C	Protein involved in bud-site selection	genetic	6	2	5	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KIN3	YAR018C	Nonessential serine/threonine protein kinase	genetic	6	2	5	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET2	YER083C	Subunit of the GET complex	genetic	6	2	5	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
CKB1	YGL019W	Beta regulatory subunit of casein kinase 2 (CK2)	genetic	6	1	5	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKB2	YOR039W	Beta' regulatory subunit of casein kinase 2 (CK2)	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELM1	YKL048C	Serine/threonine protein kinase	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ZDS1	YMR273C	Protein with a role in regulating Swe1p-dependent polarized growth	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTS1	YOR014W	B-type regulatory subunit of protein phosphatase 2A (PP2A)	genetic	6	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GIN4	YDR507C	Protein kinase involved in bud growth and assembly of the septin ring	genetic	5	2	5	Negative Genetic, Negative Genetic, Dosage Growth Defect, Negative Genetic, Negative Genetic
PTP2	YOR208W	Phosphotyrosine-specific phosphatase	genetic	5	2	5	Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CAP1	YKL007W	Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p)	genetic	5	3	4	Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TLG2	YOL018C	Syntaxin-like t-SNARE	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBP3	YER151C	Ubiquitin-specific protease that cleaves Ub-protein fusions	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUD6	YLR319C	Actin- and formin-interacting protein	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CYK3	YDL117W	SH3-domain protein located in the bud neck and cytokinetic actin ring	genetic	5	2	4	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BEM3	YPL115C	Rho GTPase activating protein (RhoGAP)	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWI4	YER111C	DNA binding component of the SBF complex (Swi4p-Swi6p)	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SKN7	YHR206W	Nuclear response regulator and transcription factor	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SNF1	YDR477W	AMP-activated S/T protein kinase	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IRC21	YMR073C	Protein of unknown function	genetic	5	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ALG8	YOR067C	Glucosyl transferase	genetic	5	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TAP42	YMR028W	Essential protein involved in the TOR signaling pathway	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MMR1	YLR190W	Phosphorylated protein of the mitochondrial outer membrane	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ELP6	YMR312W	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BST1	YFL025C	GPI inositol deacylase of the endoplasmic reticulum (ER)	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MOT3	YMR070W	Transcriptional repressor, activator	genetic	5	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTG2	YGL252C	Sensor of mitochondrial dysfunction	genetic	4	4	4	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Positive Genetic
GIM5	YML094W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	4	2	4	Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality
MSG5	YNL053W	Dual-specificity protein phosphatase	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SNF4	YGL115W	Activating gamma subunit of the AMP-activated Snf1p kinase complex	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RRD1	YIL153W	Peptidyl-prolyl cis/trans-isomerase	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RRD2	YPL152W	Peptidyl-prolyl cis/trans-isomerase	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KIN4	YOR233W	Serine/threonine protein kinase	genetic	4	1	4	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VAM7	YGL212W	Vacuolar SNARE protein	genetic	4	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VPS4	YPR173C	AAA-ATPase involved in multivesicular body (MVB) protein sorting	genetic	4	2	3	Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
GWT1	YJL091C	Protein involved in the inositol acylation of GlcN-PI	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KES1	YPL145C	Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKS1	YBR135W	Cyclin-dependent protein kinase regulatory subunit and adaptor	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MYO2	YOR326W	Type V myosin motor involved in actin-based transport of cargos	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
APM3	YBR288C	Mu3-like subunit of the clathrin associated protein complex (AP-3)	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
EXO70	YJL085W	Subunit of the exocyst complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PKC1	YBL105C	Protein serine/threonine kinase	genetic	4	1	3	Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
VAM6	YDL077C	Guanine nucleotide exchange factor for the GTPase Gtr1p	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TRS65	YGR166W	Component of transport protein particle (TRAPP) complex II	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SYS1	YJL004C	Integral membrane protein of the Golgi	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS51	YKR020W	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SUB1	YMR039C	Transcriptional regulator	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TPM1	YNL079C	Major isoform of tropomyosin	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RGA1	YOR127W	GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP)	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC15	YGL233W	Essential 113 kDa subunit of the exocyst complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OST2	YOR103C	Epsilon subunit of the oligosaccharyltransferase complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HOC1	YJR075W	Alpha-1,6-mannosyltransferase	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARL3	YPL051W	ARF-like small GTPase of the RAS superfamily	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GAB1	YLR459W	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KEX1	YGL203C	Cell death protease essential for hypochlorite-induced apoptosis	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERD1	YDR414C	Predicted membrane protein required for lumenal ER protein retention	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LAS21	YJL062W	Mannose-ethanolamine phosphotransferase	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LST4	YKL176C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	genetic	4	1	3	Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BIM1	YER016W	Microtubule plus end-tracking protein	genetic	4	2	2	Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect
ESA1	YOR244W	Catalytic subunit of the histone acetyltransferase complex (NuA4)	genetic	4	1	2	Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
HOG1	YLR113W	Mitogen-activated protein kinase involved in osmoregulation	genetic	3	3	3	Synthetic Rescue, Dosage Lethality, Positive Genetic
SKM1	YOL113W	Member of the PAK family of serine/threonine protein kinases	physical	3	3	3	Two-hybrid, Affinity Capture-MS, Protein-peptide
MON1	YGL124C	Subunit of a heterodimeric guanine nucleotide exchange factor (GEF)	genetic	3	3	3	Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
CAP2	YIL034C	Beta subunit of the capping protein heterodimer (Cap1p and Cap2p)	genetic	3	3	3	Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
NAP1	YKR048C	Histone chaperone and assembly chaperone for Rps6a/b	physical	3	2	3	Two-hybrid, PCA, PCA
FAB1	YFR019W	1-phosphatidylinositol-3-phosphate 5-kinase	genetic	3	2	3	Synthetic Lethality, Positive Genetic, Synthetic Lethality
CMD1	YBR109C	Calmodulin	genetic	3	2	3	Negative Genetic, Negative Genetic, Positive Genetic
GET1	YGL020C	Subunit of the GET complex	genetic	3	2	3	Negative Genetic, Synthetic Lethality, Negative Genetic
PTC1	YDL006W	Type 2C protein phosphatase (PP2C)	genetic	3	2	3	Positive Genetic, Positive Genetic, Dosage Rescue
PAC10	YGR078C	Part of the heteromeric co-chaperone GimC/prefoldin complex	genetic	3	2	3	Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
PKR1	YMR123W	V-ATPase assembly factor	genetic	3	2	3	Synthetic Growth Defect, Negative Genetic, Negative Genetic
BNI4	YNL233W	Targeting subunit for Glc7p protein phosphatase	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
MKK1	YOR231W	MAPKK involved in the protein kinase C signaling pathway	genetic	3	2	3	Synthetic Rescue, Positive Genetic, Positive Genetic
KRE1	YNL322C	Cell wall glycoprotein involved in beta-glucan assembly	genetic	3	2	3	Negative Genetic, Synthetic Growth Defect, Negative Genetic
APL6	YGR261C	Beta3-like subunit of the yeast AP-3 complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CDC23	YHR166C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
FLC2	YAL053W	Putative calcium channel involved in calcium release under hypotonic	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MEH1	YKR007W	Subunit of the EGO/GSE complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
POL3	YDL102W	Catalytic subunit of DNA polymerase delta	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
SAC7	YDR389W	GTPase activating protein (GAP) for Rho1p	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PIB2	YGL023C	Phosphatidylinositol 3-phosphate binding protein	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
RPL14A	YKL006W	Ribosomal 60S subunit protein L14A	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
VPS17	YOR132W	Subunit of the membrane-associated retromer complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
GTR1	YML121W	Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
COG6	YNL041C	Component of the conserved oligomeric Golgi complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
COG5	YNL051W	Component of the conserved oligomeric Golgi complex	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
BRE5	YNR051C	Ubiquitin protease cofactor	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CBF1	YJR060W	Basic helix-loop-helix (bHLH) protein	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
DFG5	YMR238W	Putative mannosidase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MOG1	YJR074W	Conserved nuclear protein that interacts with GTP-Gsp1p	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
IMP21	YIL154C	Transcriptional activator involved in maintenance of ion homeostasis	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
GUP1	YGL084C	Plasma membrane protein involved in remodeling GPI anchors	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
MNN2	YBR015C	Alpha-1,2-mannosyltransferase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
ERG3	YLR056W	C-5 sterol desaturase	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
CCW12	YLR110C	Cell wall mannoprotein	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
IRS4	YKR019C	EH domain-containing protein	genetic	3	1	3	Negative Genetic, Negative Genetic, Negative Genetic
PFY1	YOR122C	Profilin	genetic	3	2	2	Synthetic Growth Defect, Negative Genetic, Negative Genetic
ALG6	YOR002W	ER-luminal alpha 1,3 glucosyltransferase	genetic	3	2	2	Synthetic Growth Defect, Negative Genetic, Negative Genetic
BEM2	YER155C	Rho GTPase activating protein (RhoGAP)	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
COG8	YML071C	Component of the conserved oligomeric Golgi complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
FAR11	YNL127W	Protein involved in recovery from cell cycle arrest	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
HIR2	YOR038C	Subunit of HIR nucleosome assembly complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
DIA2	YOR080W	Origin-binding F-box protein	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
PMT2	YAL023C	Protein O-mannosyltransferase of the ER membrane	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
YSC83	YHR017W	Non-essential mitochondrial protein of unknown function	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
VPS9	YML097C	Guanine nucleotide exchange factor (GEF) and ubiquitin receptor	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
STT3	YGL022W	Catalytic subunit of the oligosaccharyltransferase complex of the ER l	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
ELP4	YPL101W	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
ATS1	YAL020C	Protein required for modification of wobble nucleosides in tRNA	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
ALG5	YPL227C	UDP-glucose:dolichyl-phosphate glucosyltransferase	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
MNN11	YJL183W	Subunit of a Golgi mannosyltransferase complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
MRC1	YCL061C	S-phase checkpoint protein required for DNA replication	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
GAA1	YLR088W	Subunit of the GPI:protein transamidase complex	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
FPS1	YLL043W	Aquaglyceroporin, plasma membrane channel	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
GPI10	YGL142C	Integral membrane protein involved in GPI anchor synthesis	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
ECM8	YBR076W	Non-essential protein of unknown function	genetic	3	1	2	Negative Genetic, Negative Genetic, Negative Genetic
GIN4	YDR507C	Protein kinase involved in bud growth and assembly of the septin ring	physical	3	2	1	PCA, PCA, Reconstituted Complex
BEM4	YPL161C	Protein involved in establishment of cell polarity and bud emergence	physical	3	2	1	PCA, PCA, Reconstituted Complex
SRN2	YLR119W	Component of the ESCRT-I complex	genetic	3	2	1	Negative Genetic, Positive Genetic, Positive Genetic
NAP1	YKR048C	Histone chaperone and assembly chaperone for Rps6a/b	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
CFT2	YLR115W	Subunit of the mRNA cleavage and polyadenlylation factor (CPF)	genetic	2	2	2	Positive Genetic, Negative Genetic
FPR1	YNL135C	Peptidyl-prolyl cis-trans isomerase (PPIase)	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
HSC82	YMR186W	Cytoplasmic chaperone of the Hsp90 family	genetic	2	2	2	Synthetic Growth Defect, Positive Genetic
MNN10	YDR245W	Subunit of a Golgi mannosyltransferase complex	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
CPR6	YLR216C	Peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
VPS29	YHR012W	Subunit of the membrane-associated retromer complex	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RPL16A	YIL133C	Ribosomal 60S subunit protein L16A	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RPS18B	YML026C	Protein component of the small (40S) ribosomal subunit	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RPS23A	YGR118W	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RTT109	YLL002W	Histone acetyltransferase	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RTG3	YBL103C	bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
SYO1	YDL063C	Transport adaptor or symportin	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
NCS6	YGL211W	Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
RIC1	YLR039C	Protein involved in retrograde transport to the cis-Golgi network	genetic	2	2	2	Synthetic Lethality, Negative Genetic
SSK2	YNR031C	MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway	genetic	2	2	2	Dosage Lethality, Positive Genetic
PTC2	YER089C	Type 2C protein phosphatase (PP2C)	genetic	2	2	2	Dosage Rescue, Negative Genetic
PMR1	YGL167C	High affinity Ca2+/Mn2+ P-type ATPase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
OPI3	YJR073C	Methylene-fatty-acyl-phospholipid synthase	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
TOP1	YOL006C	Topoisomerase I	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
TOR1	YJR066W	PIK-related protein kinase and rapamycin target	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
VMA21	YGR105W	Integral membrane protein required for V-ATPase function	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
RIA1	YNL163C	Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
MPS1	YDL028C	Dual-specificity kinase	physical	2	2	2	Two-hybrid, Affinity Capture-MS
CLA4	YNL298W	Cdc42p-activated signal transducing kinase	genetic	2	2	2	Negative Genetic, Dosage Growth Defect
CIN2	YPL241C	GTPase-activating protein (GAP) for Cin4p	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
HCM1	YCR065W	Forkhead transcription factor	genetic	2	2	2	Synthetic Growth Defect, Negative Genetic
CLB4	YLR210W	B-type cyclin involved in cell cycle progression	genetic	2	2	2	Synthetic Lethality, Synthetic Growth Defect
DBP9	YLR276C	DEAD-box protein required for 27S rRNA processing	genetic	2	1	2	Negative Genetic, Negative Genetic
MES1	YGR264C	Methionyl-tRNA synthetase	genetic	2	1	2	Negative Genetic, Negative Genetic
ATP11	YNL315C	Molecular chaperone	genetic	2	1	2	Negative Genetic, Negative Genetic
CDC55	YGL190C	Regulatory subunit B of protein phosphatase 2A (PP2A)	genetic	2	1	2	Negative Genetic, Negative Genetic
HDA1	YNL021W	Catalytic subunit of class II HDA1 histone deacetylase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
ELP2	YGR200C	Subunit of Elongator complex	genetic	2	1	2	Negative Genetic, Negative Genetic
GDI1	YER136W	GDP dissociation inhibitor	genetic	2	1	2	Negative Genetic, Negative Genetic
LST8	YNL006W	Protein required for the transport of Gap1p	genetic	2	1	2	Negative Genetic, Negative Genetic
NAB6	YML117W	Putative RNA-binding protein	genetic	2	1	2	Negative Genetic, Negative Genetic
ACE2	YLR131C	Transcription factor required for septum destruction after cytokinesis	genetic	2	1	2	Negative Genetic, Negative Genetic
APP1	YNL094W	Phosphatidate phosphatase, converts phosphatidate to diacylglycerol	physical	2	1	2	Two-hybrid, Two-hybrid
MRS6	YOR370C	Rab escort protein	genetic	2	1	2	Positive Genetic, Positive Genetic
FAR10	YLR238W	Protein involved in recovery from arrest in response to pheromone	genetic	2	1	2	Negative Genetic, Negative Genetic
BCK2	YER167W	Serine/threonine-rich protein involved in PKC1 signaling pathway	genetic	2	1	2	Negative Genetic, Negative Genetic
HAL5	YJL165C	Snf1p-related nutrient-responsive protein kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
CLN2	YPL256C	G1 cyclin involved in regulation of the cell cycle	genetic	2	1	2	Negative Genetic, Negative Genetic
CYS3	YAL012W	Cystathionine gamma-lyase	genetic	2	1	2	Negative Genetic, Negative Genetic
PBS2	YJL128C	MAP kinase kinase of the HOG signaling pathway	genetic	2	1	2	Positive Genetic, Positive Genetic
RTK1	YDL025C	Putative protein kinase, potentially phosphorylated by Cdc28p	genetic	2	1	2	Positive Genetic, Positive Genetic
PPH21	YDL134C	Catalytic subunit of protein phosphatase 2A, PP2A	genetic	2	1	2	Negative Genetic, Negative Genetic
PPM1	YDR435C	Carboxyl methyltransferase	genetic	2	1	2	Negative Genetic, Negative Genetic
YCK1	YHR135C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	genetic	2	1	2	Negative Genetic, Negative Genetic
PTK2	YJR059W	Serine/threonine protein kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
PRR1	YKL116C	Serine/threonine protein kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
RFA2	YNL312W	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	2	1	2	Negative Genetic, Negative Genetic
PPG1	YNR032W	Serine protein phosphatase involved in formation of FAR complex	genetic	2	1	2	Negative Genetic, Negative Genetic
ORC2	YBR060C	Subunit of the origin recognition complex (ORC)	genetic	2	1	2	Negative Genetic, Negative Genetic
VMA1	YDL185W	Subunit A of the V1 peripheral membrane domain of V-ATPase	genetic	2	1	2	Negative Genetic, Negative Genetic
PER1	YCR044C	Protein of the endoplasmic reticulum	genetic	2	1	2	Negative Genetic, Negative Genetic
PCP1	YGR101W	Mitochondrial serine protease	genetic	2	1	2	Negative Genetic, Negative Genetic
TIP41	YPR040W	Tap42p-interacting protein	genetic	2	1	2	Negative Genetic, Negative Genetic
SEC13	YLR208W	Structural component of 3 complexes	genetic	2	1	2	Negative Genetic, Negative Genetic
URE2	YNL229C	Nitrogen catabolite repression transcriptional regulator	genetic	2	1	2	Negative Genetic, Negative Genetic
PSD1	YNL169C	Phosphatidylserine decarboxylase of the mitochondrial inner membrane	genetic	2	1	2	Negative Genetic, Negative Genetic
YDJ1	YNL064C	Type I HSP40 co-chaperone	genetic	2	1	2	Positive Genetic, Positive Genetic
SCS7	YMR272C	Sphingolipid alpha-hydroxylase	genetic	2	1	2	Positive Genetic, Positive Genetic
SGT2	YOR007C	Glutamine-rich cytoplasmic cochaperone	genetic	2	1	2	Positive Genetic, Positive Genetic
SUR1	YPL057C	Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit	genetic	2	1	2	Positive Genetic, Positive Genetic
SEC16	YPL085W	COPII vesicle coat protein required for ER transport vesicle budding	genetic	2	1	2	Negative Genetic, Negative Genetic
TRS20	YBR254C	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	1	2	Negative Genetic, Negative Genetic
RSP5	YER125W	NEDD4 family E3 ubiquitin ligase	genetic	2	1	2	Negative Genetic, Negative Genetic
SEC53	YFL045C	Phosphomannomutase	genetic	2	1	2	Negative Genetic, Negative Genetic
SEC61	YLR378C	Conserved ER protein translocation channel	genetic	2	1	2	Negative Genetic, Negative Genetic
YUR1	YJL139C	Mannosyltransferase involved in protein N-glycosylation	genetic	2	1	2	Negative Genetic, Negative Genetic
OPI1	YHL020C	Transcriptional regulator of a variety of genes	genetic	2	1	2	Negative Genetic, Negative Genetic
DUO1	YGL061C	Essential subunit of the Dam1 complex (aka DASH complex)	genetic	2	1	2	Negative Genetic, Negative Genetic
GPI16	YHR188C	Subunit of the glycosylphosphatidylinositol transamidase complex	genetic	2	1	2	Negative Genetic, Negative Genetic
ELP3	YPL086C	Subunit of Elongator complex	genetic	2	1	2	Negative Genetic, Negative Genetic
ARP6	YLR085C	Actin-related protein that binds nucleosomes	genetic	2	1	2	Positive Genetic, Positive Genetic
IES2	YNL215W	Protein that associates with the INO80 chromatin remodeling complex	genetic	2	1	2	Positive Genetic, Positive Genetic
CTK2	YJL006C	Beta subunit of C-terminal domain kinase I (CTDK-I)	genetic	2	1	2	Negative Genetic, Negative Genetic
KAR9	YPL269W	Spindle positioning factor	genetic	2	1	2	Synthetic Lethality, Synthetic Lethality
MDM12	YOL009C	Mitochondrial outer membrane protein, ERMES complex subunit	genetic	2	1	2	Negative Genetic, Negative Genetic
MGM1	YOR211C	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p	genetic	2	1	2	Negative Genetic, Negative Genetic
CSG2	YBR036C	Endoplasmic reticulum membrane protein	genetic	2	1	2	Positive Genetic, Positive Genetic
INP53	YOR109W	Polyphosphatidylinositol phosphatase	genetic	2	1	2	Negative Genetic, Negative Genetic
CSF1	YLR087C	Protein with structural similarity to lipid transport protein Vps13p	genetic	2	1	2	Negative Genetic, Negative Genetic
AIM29	YKR074W	Protein of unknown function	genetic	2	1	2	Negative Genetic, Negative Genetic
KIP3	YGL216W	Kinesin-related antiparallel sliding motor protein	genetic	2	1	2	Synthetic Lethality, Synthetic Lethality
ALG14	YBR070C	Component of UDP-GlcNAc transferase	genetic	2	1	2	Negative Genetic, Negative Genetic
CDC8	YJR057W	Nucleoside monophosphate and nucleoside diphosphate kinase	genetic	2	1	2	Negative Genetic, Negative Genetic
GPI15	YNL038W	Protein involved in the synthesis of GlcNAc-PI	genetic	2	1	2	Negative Genetic, Negative Genetic
APS3	YJL024C	Small subunit of the clathrin-associated adaptor complex AP-3	genetic	2	1	2	Negative Genetic, Negative Genetic
DFR1	YOR236W	Dihydrofolate reductase involved in tetrahydrofolate biosynthesis	genetic	2	1	2	Negative Genetic, Negative Genetic
ATX2	YOR079C	Golgi membrane protein involved in manganese homeostasis	genetic	2	1	2	Negative Genetic, Negative Genetic
KRE5	YOR336W	Protein required for beta-1,6 glucan biosynthesis	genetic	2	1	2	Negative Genetic, Negative Genetic
MVB12	YGR206W	ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers	genetic	2	2	1	Negative Genetic, Positive Genetic
ARP4	YJL081C	Nuclear actin-related protein involved in chromatin remodeling	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
EAF1	YDR359C	Component of the NuA4 histone acetyltransferase complex	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
ACT1	YFL039C	Actin, structural protein in cytoskeleton	genetic	2	1	1	Negative Genetic, Negative Genetic
EPL1	YFL024C	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
KCC4	YCL024W	Protein kinase of the bud neck involved in the septin checkpoint	physical	2	1	1	PCA, PCA
FYV8	YGR196C	Protein of unknown function	genetic	2	1	1	Positive Genetic, Positive Genetic
BET5	YML077W	Core component of transport protein particle (TRAPP) complexes I-III	genetic	2	1	1	Negative Genetic, Negative Genetic
HSE1	YHL002W	Subunit of the endosomal Vps27p-Hse1p complex	genetic	2	1	1	Positive Genetic, Positive Genetic
EGD1	YPL037C	Subunit beta1 of the nascent polypeptide-associated complex (NAC)	genetic	2	1	1	Negative Genetic, Negative Genetic
EPT1	YHR123W	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase	genetic	2	1	1	Negative Genetic, Negative Genetic
YNG2	YHR090C	Subunit of NuA4, an essential histone acetyltransferase complex	genetic	2	1	1	Synthetic Growth Defect, Synthetic Growth Defect
SKT5	YBL061C	Activator of Chs3p (chitin synthase III) during vegetative growth	genetic	2	1	1	Negative Genetic, Negative Genetic
YJL068C	YJL068C	Esterase that can function as an S-formylglutathione hydrolase	genetic	2	1	1	Negative Genetic, Negative Genetic
PET20	YPL159C	Mitochondrial protein	genetic	2	1	1	Negative Genetic, Negative Genetic
THP3	YPR045C	Protein that may have a role in transcription elongation	genetic	2	1	1	Negative Genetic, Negative Genetic
POL1	YNL102W	Catalytic subunit of the DNA polymerase I alpha-primase complex	genetic	2	1	1	Negative Genetic, Negative Genetic
SRV2	YNL138W	CAP (cyclase-associated protein)	genetic	2	1	1	Negative Genetic, Negative Genetic
SMP3	YOR149C	Alpha 1,2-mannosyltransferase	genetic	2	1	1	Negative Genetic, Negative Genetic
VPS38	YLR360W	Part of a Vps34p phosphatidylinositol 3-kinase complex	genetic	2	1	1	Positive Genetic, Positive Genetic
PEP8	YJL053W	Vacuolar protein component of the retromer	genetic	2	1	1	Negative Genetic, Negative Genetic
CSM1	YCR086W	Nucleolar protein that mediates homolog segregation during meiosis I	genetic	2	1	1	Negative Genetic, Negative Genetic
MOB2	YFL034C-B	Activator of Cbk1p kinase	genetic	2	1	1	Negative Genetic, Negative Genetic
AIM3	YBR108W	Protein that inhibits barbed-end actin filament elongation	genetic	2	1	1	Positive Genetic, Positive Genetic
MVP1	YMR004W	Protein required for sorting proteins to the vacuole	genetic	2	1	1	Negative Genetic, Negative Genetic
HXK2	YGL253W	Hexokinase isoenzyme 2	genetic	2	1	1	Negative Genetic, Negative Genetic
EAF7	YNL136W	Subunit of the NuA4 histone acetyltransferase complex	genetic	2	1	1	Negative Genetic, Negative Genetic
DPM1	YPR183W	Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane	genetic	2	1	1	Negative Genetic, Negative Genetic
DCC1	YCL016C	Subunit of a complex with Ctf8p and Ctf18p	genetic	2	1	1	Negative Genetic, Negative Genetic
MCY1	YGR012W	Putative cysteine synthase	genetic	2	1	1	Negative Genetic, Negative Genetic
GPI17	YDR434W	Transmembrane protein	genetic	2	1	1	Negative Genetic, Negative Genetic
DEG1	YFL001W	tRNA:pseudouridine synthase	genetic	2	1	1	Negative Genetic, Negative Genetic
DFG16	YOR030W	Probable multiple transmembrane protein	genetic	2	1	1	Negative Genetic, Negative Genetic
ALG2	YGL065C	Mannosyltransferase in the N-linked glycosylation pathway	genetic	2	1	1	Negative Genetic, Negative Genetic
YAP5	YIR018W	Basic leucine zipper (bZIP) iron-sensing transcription factor	regulation	1	1	1	chromatin immunoprecipitation-chip evidence
CHD1	YER164W	Chromatin remodeler that regulates various aspects of transcription	genetic	1	1	1	Positive Genetic
CTF19	YPL018W	Outer kinetochore protein, needed for accurate chromosome segregation	genetic	1	1	1	Positive Genetic
MCM22	YJR135C	Outer kinetochore protein and component of the Ctf3 subcomplex	genetic	1	1	1	Positive Genetic
CKA2	YOR061W	Alpha' catalytic subunit of casein kinase 2 (CK2)	genetic	1	1	1	Negative Genetic
GLC7	YER133W	Type 1 S/T protein phosphatase (PP1) catalytic subunit	genetic	1	1	1	Negative Genetic
HAS1	YMR290C	ATP-dependent RNA helicase	genetic	1	1	1	Negative Genetic
BRE1	YDL074C	E3 ubiquitin ligase	genetic	1	1	1	Negative Genetic
BMH1	YER177W	14-3-3 protein, major isoform	genetic	1	1	1	Negative Genetic
HCA4	YJL033W	DEAD box RNA helicase	genetic	1	1	1	Negative Genetic
MTR4	YJL050W	RNA duplex-sensing translocase	genetic	1	1	1	Negative Genetic
LSM1	YJL124C	Lsm (Like Sm) protein	genetic	1	1	1	Negative Genetic
LRP1	YHR081W	Nuclear exosome-associated nucleic acid binding protein	genetic	1	1	1	Negative Genetic
CBC2	YPL178W	Small subunit of the heterodimeric cap binding complex with Sto1p	genetic	1	1	1	Positive Genetic
GCD11	YER025W	Gamma subunit of the translation initiation factor eIF2	genetic	1	1	1	Negative Genetic
MED4	YOR174W	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Positive Genetic
DST1	YGL043W	General transcription elongation factor TFIIS	genetic	1	1	1	Negative Genetic
GCD2	YGR083C	Delta subunit of the translation initiation factor eIF2B	genetic	1	1	1	Negative Genetic
MPE1	YKL059C	Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase	genetic	1	1	1	Negative Genetic
AAH1	YNL141W	Adenine deaminase (adenine aminohydrolase)	genetic	1	1	1	Negative Genetic
CCR4	YAL021C	Component of the CCR4-NOT transcriptional complex	physical	1	1	1	Affinity Capture-RNA
KAP104	YBR017C	Transportin or cytosolic karyopherin beta 2	genetic	1	1	1	Positive Genetic
NAB2	YGL122C	Nuclear polyadenylated RNA-binding protein	physical	1	1	1	Affinity Capture-RNA
NAM7	YMR080C	ATP-dependent RNA helicase of the SFI superfamily	genetic	1	1	1	Negative Genetic
APL5	YPL195W	Delta adaptin-like subunit of the clathrin associated protein complex	genetic	1	1	1	Negative Genetic
BDF1	YLR399C	BET family transcriptional regulator	genetic	1	1	1	Negative Genetic
BEM1	YBR200W	Protein containing SH3-domains	genetic	1	1	1	Negative Genetic
BOI2	YER114C	Protein involved in polar growth	physical	1	1	1	Protein-peptide
BOI2	YER114C	Protein involved in polar growth	genetic	1	1	1	Negative Genetic
CDC24	YAL041W	Guanine nucleotide exchange factor (GEF) for Cdc42p	genetic	1	1	1	Negative Genetic
CDC11	YJR076C	Component of the septin ring that is required for cytokinesis	genetic	1	1	1	Negative Genetic
CDC55	YGL190C	Regulatory subunit B of protein phosphatase 2A (PP2A)	physical	1	1	1	Two-hybrid
AVO1	YOL078W	Component of the membrane-bound TORC2 complex	genetic	1	1	1	Positive Genetic
DCP2	YNL118C	Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex	genetic	1	1	1	Negative Genetic
ERO1	YML130C	Thiol oxidase required for oxidative protein folding in the ER	genetic	1	1	1	Negative Genetic
EXO84	YBR102C	Exocyst subunit with dual roles in exocytosis and spliceosome assembly	genetic	1	1	1	Negative Genetic
FKS1	YLR342W	Catalytic subunit of 1,3-beta-D-glucan synthase	genetic	1	1	1	Negative Genetic
CCT4	YDL143W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Negative Genetic
GLO3	YER122C	ADP-ribosylation factor GTPase activating protein (ARF GAP)	genetic	1	1	1	Negative Genetic
ACK1	YDL203C	Protein that functions in the cell wall integrity pathway	genetic	1	1	1	Positive Genetic
HSL1	YKL101W	Nim1p-related protein kinase	physical	1	1	1	PCA
CRM1	YGR218W	Nuclear export factor, exportin	physical	1	1	1	Affinity Capture-MS
LCB1	YMR296C	Component of serine palmitoyltransferase	genetic	1	1	1	Positive Genetic
MAK5	YBR142W	Essential nucleolar protein	genetic	1	1	1	Negative Genetic
MAL12	YGR292W	Maltase (alpha-D-glucosidase)	genetic	1	1	1	Positive Genetic
MDM10	YAL010C	Subunit of both the ERMES and the SAM complex	genetic	1	1	1	Negative Genetic
MTR10	YOR160W	Nuclear import receptor	genetic	1	1	1	Negative Genetic
HTZ1	YOL012C	Histone variant H2AZ	genetic	1	1	1	Negative Genetic
KCC4	YCL024W	Protein kinase of the bud neck involved in the septin checkpoint	genetic	1	1	1	Dosage Lethality
IES5	YER092W	Non-essential INO80 chromatin remodeling complex subunit	genetic	1	1	1	Positive Genetic
FAS2	YPL231W	Alpha subunit of fatty acid synthetase	genetic	1	1	1	Negative Genetic
APM1	YPL259C	Mu1-like medium subunit of the AP-1 complex	genetic	1	1	1	Negative Genetic
HSP82	YPL240C	Hsp90 chaperone	genetic	1	1	1	Synthetic Growth Defect
ESF2	YNR054C	Essential nucleolar protein involved in pre-18S rRNA processing	genetic	1	1	1	Negative Genetic
ILV1	YER086W	Threonine deaminase, catalyzes first step in isoleucine biosynthesis	physical	1	1	1	Two-hybrid
DEP1	YAL013W	Component of the Rpd3L histone deacetylase complex	genetic	1	1	1	Negative Genetic
DBP2	YNL112W	ATP-dependent RNA helicase of the DEAD-box protein family	genetic	1	1	1	Positive Genetic
ANP1	YEL036C	Subunit of the alpha-1,6 mannosyltransferase complex	genetic	1	1	1	Negative Genetic
INP52	YNL106C	Polyphosphatidylinositol phosphatase	genetic	1	1	1	Positive Genetic
CCT8	YJL008C	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Negative Genetic
BRR1	YPR057W	snRNP protein component of spliceosomal snRNPs	genetic	1	1	1	Positive Genetic
GCN5	YGR252W	Catalytic subunit of ADA and SAGA histone acetyltransferase complexes	genetic	1	1	1	Negative Genetic
MLP1	YKR095W	Myosin-like protein associated with the nuclear envelope	genetic	1	1	1	Positive Genetic
IST2	YBR086C	Cortical ER protein involved in ER-plasma membrane (PM) tethering	genetic	1	1	1	Negative Genetic
CCT7	YJL111W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Negative Genetic
DRS2	YAL026C	Trans-golgi network aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
BOI1	YBL085W	Protein involved in polar growth, functionally redundant with Boi2p	physical	1	1	1	Protein-peptide
GET4	YOR164C	Protein involved in inserting tail-anchored proteins into ER membranes	genetic	1	1	1	Positive Genetic
CDC13	YDL220C	Single stranded DNA-binding protein found at TG1-3 telomere G-tails	genetic	1	1	1	Negative Genetic
DNM1	YLL001W	Dynamin-related GTPase involved in mitochondrial organization	genetic	1	1	1	Positive Genetic
ADO1	YJR105W	Adenosine kinase	genetic	1	1	1	Negative Genetic
KIN1	YDR122W	S/T protein kinase	physical	1	1	1	PCA
GSF2	YML048W	Endoplasmic reticulum (ER) localized integral membrane protein	genetic	1	1	1	Negative Genetic
KOG1	YHR186C	Subunit of TORC1	genetic	1	1	1	Negative Genetic
DUN1	YDL101C	Cell-cycle checkpoint S/T protein kinase	genetic	1	1	1	Negative Genetic
CLN1	YMR199W	G1 cyclin involved in regulation of the cell cycle	genetic	1	1	1	Negative Genetic
COF1	YLL050C	Cofilin, involved in pH-dependent actin filament depolarization	genetic	1	1	1	Negative Genetic
MDM30	YLR368W	F-box component of an SCF ubiquitin protein ligase complex	genetic	1	1	1	Negative Genetic
AYR1	YIL124W	Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase	genetic	1	1	1	Positive Genetic
CBK1	YNL161W	Serine/threonine protein kinase of the the RAM signaling network	genetic	1	1	1	Synthetic Growth Defect
CDC20	YGL116W	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
CCT3	YJL014W	Subunit of the cytosolic chaperonin Cct ring complex	genetic	1	1	1	Positive Genetic
HSL7	YBR133C	Protein arginine N-methyltransferase	genetic	1	1	1	Negative Genetic
CDC60	YPL160W	Cytosolic leucyl tRNA synthetase	genetic	1	1	1	Negative Genetic
IPA1	YJR141W	Protein implicated in pre-mRNA processing and proteasomal degradation	genetic	1	1	1	Negative Genetic
EST1	YLR233C	TLC1 RNA-associated factor involved in telomere length regulation	genetic	1	1	1	Synthetic Growth Defect
CDC4	YFL009W	F-box protein required for both the G1/S and G2/M phase transitions	genetic	1	1	1	Positive Genetic
ERG6	YML008C	Delta(24)-sterol C-methyltransferase	genetic	1	1	1	Negative Genetic
FRS2	YFL022C	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase	genetic	1	1	1	Positive Genetic
ADD66	YKL206C	Protein involved in 20S proteasome assembly	genetic	1	1	1	Negative Genetic
HYM1	YKL189W	Component of the RAM signaling network	genetic	1	1	1	Synthetic Growth Defect
AIM46	YHR199C	Protein of unknown function	genetic	1	1	1	Positive Genetic
MCX1	YBR227C	Non-proteolytic ATPase of the AAA family	genetic	1	1	1	Positive Genetic
KSP1	YHR082C	Serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
AIP5	YFR016C	Protein that positively regulates actin assembly	genetic	1	1	1	Synthetic Rescue
CTF4	YPR135W	Chromatin-associated protein	genetic	1	1	1	Synthetic Growth Defect
DPB11	YJL090C	DNA replication initiation protein	genetic	1	1	1	Negative Genetic
MRE11	YMR224C	Nuclease subunit of the MRX complex with Rad50p and Xrs2p	genetic	1	1	1	Positive Genetic
BEM4	YPL161C	Protein involved in establishment of cell polarity and bud emergence	genetic	1	1	1	Negative Genetic
KIN28	YDL108W	Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly	genetic	1	1	1	Negative Genetic
HAP3	YBL021C	Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex	genetic	1	1	1	Positive Genetic
FZO1	YBR179C	Mitofusin, protein involved in mitochondrial outer membrane fusion	genetic	1	1	1	Negative Genetic
EAP1	YKL204W	eIF4E-associated protein, competes with eIF4G for binding to eIF4E	genetic	1	1	1	Positive Genetic
CPR3	YML078W	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin)	genetic	1	1	1	Positive Genetic
MIG1	YGL035C	Transcription factor involved in glucose repression	physical	1	1	1	Two-hybrid
DBF2	YGR092W	Ser/Thr kinase involved in transcription and stress response	genetic	1	1	1	Negative Genetic
BUB3	YOR026W	Kinetochore checkpoint WD40 repeat protein	genetic	1	1	1	Positive Genetic
FUS3	YBL016W	Mitogen-activated serine/threonine protein kinase involved in mating	genetic	1	1	1	Positive Genetic
CDH1	YGL003C	Activator of anaphase-promoting complex/cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
ATP7	YKL016C	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase	genetic	1	1	1	Negative Genetic
STE20	YHL007C	Cdc42p-activated signal transducing kinase	genetic	1	1	1	Dosage Lethality
RRP7	YCL031C	Essential protein involved in rRNA processing and ribosome biogenesis	physical	1	1	1	Two-hybrid
SKM1	YOL113W	Member of the PAK family of serine/threonine protein kinases	genetic	1	1	1	Positive Genetic
YAP7	YOL028C	Transcriptional repressor of nitric oxide oxidase	physical	1	1	1	Two-hybrid
ZDS2	YML109W	Protein with a role in regulating Swe1p-dependent polarized growth	physical	1	1	1	Two-hybrid
TPD3	YAL016W	Regulatory subunit A of the heterotrimeric PP2A complex	physical	1	1	1	Two-hybrid
STE7	YDL159W	Signal transducing MAP kinase kinase	physical	1	1	1	PCA
TCO89	YPL180W	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p)	physical	1	1	1	PCA
SPB4	YFL002C	Putative ATP-dependent RNA helicase	physical	1	1	1	Affinity Capture-MS
SSB2	YNL209W	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone	physical	1	1	1	Co-purification
PUF2	YPR042C	PUF family mRNA-binding protein	physical	1	1	1	Affinity Capture-RNA
PTC4	YBR125C	Cytoplasmic type 2C protein phosphatase (PP2C)	genetic	1	1	1	Dosage Rescue
SSD1	YDR293C	Translational repressor	genetic	1	1	1	Synthetic Growth Defect
SEF1	YBL066C	Putative transcription factor	genetic	1	1	1	Synthetic Rescue
PYK2	YOR347C	Pyruvate kinase	genetic	1	1	1	Synthetic Rescue
SEC3	YER008C	Subunit of the exocyst complex	genetic	1	1	1	Synthetic Lethality
SWA2	YDR320C	Auxilin-like protein involved in vesicular transport	genetic	1	1	1	Synthetic Lethality
SCS2	YER120W	Integral ER membrane protein, regulates phospholipid metabolism	genetic	1	1	1	Synthetic Growth Defect
SWD1	YAR003W	Subunit of the COMPASS (Set1C) complex	genetic	1	1	1	Negative Genetic
TPS1	YBR126C	Synthase subunit of trehalose-6-P synthase/phosphatase complex	genetic	1	1	1	Negative Genetic
OPY1	YBR129C	Protein of unknown function	genetic	1	1	1	Negative Genetic
YPD1	YDL235C	Osmotic stress-responsive phosphorelay intermediate sensor protein	genetic	1	1	1	Negative Genetic
TPS2	YDR074W	Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex	genetic	1	1	1	Negative Genetic
PPH3	YDR075W	Catalytic subunit of protein phosphatase PP4 complex	genetic	1	1	1	Negative Genetic
RIM15	YFL033C	Protein kinase involved in cell proliferation in response to nutrients	genetic	1	1	1	Negative Genetic
SAP155	YFR040W	Protein required for function of the Sit4p protein phosphatase	genetic	1	1	1	Negative Genetic
RRM3	YHR031C	DNA helicase involved in rDNA replication and Ty1 transposition	genetic	1	1	1	Negative Genetic
PPZ1	YML016C	Serine/threonine protein phosphatase Z, isoform of Ppz2p	genetic	1	1	1	Positive Genetic
YCK2	YNL154C	Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform	genetic	1	1	1	Negative Genetic
SEM1	YDR363W-A	19S proteasome regulatory particle lid subcomplex component	genetic	1	1	1	Positive Genetic
THR1	YHR025W	Homoserine kinase	genetic	1	1	1	Positive Genetic
SWI6	YLR182W	Transcription cofactor	genetic	1	1	1	Negative Genetic
STB1	YNL309W	Protein with role in regulation of MBF-specific transcription at Start	genetic	1	1	1	Negative Genetic
SKS1	YPL026C	Putative serine/threonine protein kinase	genetic	1	1	1	Negative Genetic
YPL150W	YPL150W	Protein kinase of unknown cellular role	genetic	1	1	1	Negative Genetic
TRA1	YHR099W	Subunit of SAGA and NuA4 histone acetyltransferase complexes	genetic	1	1	1	Synthetic Growth Defect
PDI1	YCL043C	Protein disulfide isomerase	genetic	1	1	1	Synthetic Lethality
VMA9	YCL005W-A	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex	genetic	1	1	1	Negative Genetic
RPS8A	YBL072C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
SLX5	YDL013W	Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex	genetic	1	1	1	Negative Genetic
TEF4	YKL081W	Gamma subunit of translational elongation factor eEF1B	genetic	1	1	1	Negative Genetic
RSC2	YLR357W	Component of the RSC chromatin remodeling complex	genetic	1	1	1	Positive Genetic
VPS3	YDR495C	Component of CORVET membrane tethering complex	genetic	1	1	1	Negative Genetic
THG1	YGR024C	tRNAHis guanylyltransferase	genetic	1	1	1	Negative Genetic
SPC24	YMR117C	Component of the kinetochore-associated Ndc80 complex	genetic	1	1	1	Negative Genetic
VOA1	YGR106C	ER protein that functions in assembly of the V0 sector of V-ATPase	genetic	1	1	1	Synthetic Growth Defect
SDO1	YLR022C	Guanine nucleotide exchange factor (GEF) for Ria1p	genetic	1	1	1	Synthetic Growth Defect
NPL3	YDR432W	RNA-binding protein	genetic	1	1	1	Synthetic Growth Defect
YKU70	YMR284W	Subunit of the telomeric Ku complex (Yku70p-Yku80p)	genetic	1	1	1	Negative Genetic
REB1	YBR049C	RNA polymerase I enhancer binding protein	genetic	1	1	1	Positive Genetic
POP4	YBR257W	Subunit of both RNase MRP and nuclear RNase P	genetic	1	1	1	Positive Genetic
TSC11	YER093C	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p)	genetic	1	1	1	Positive Genetic
YKT6	YKL196C	Vesicle membrane protein (v-SNARE) with acyltransferase activity	genetic	1	1	1	Positive Genetic
TIF34	YMR146C	eIF3i subunit of the eukaryotic translation initiation factor 3 (eIF3)	genetic	1	1	1	Positive Genetic
RDS3	YPR094W	Component of the SF3b subcomplex of the U2 snRNP	genetic	1	1	1	Positive Genetic
RPN12	YFR052W	Subunit of the 19S regulatory particle of the 26S proteasome lid	genetic	1	1	1	Positive Genetic
STP22	YCL008C	Component of the ESCRT-I complex	genetic	1	1	1	Positive Genetic
SWC5	YBR231C	Component of the SWR1 complex	genetic	1	1	1	Positive Genetic
YJR084W	YJR084W	Protein that forms a complex with Thp3p	genetic	1	1	1	Positive Genetic
SOM1	YEL059C-A	Subunit of the mitochondrial inner membrane peptidase (IMP)	genetic	1	1	1	Positive Genetic
YIL014C-A	YIL014C-A	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
YJR056C	YJR056C	Protein of unknown function	genetic	1	1	1	Positive Genetic
SEG2	YKL105C	Eisosome component	genetic	1	1	1	Positive Genetic
PML1	YLR016C	Subunit of the RES complex	genetic	1	1	1	Positive Genetic
TUS1	YLR425W	Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity	genetic	1	1	1	Positive Genetic
TCB3	YML072C	Cortical ER protein involved in ER-plasma membrane tethering	genetic	1	1	1	Positive Genetic
PHO91	YNR013C	Low-affinity vacuolar phosphate transporter	genetic	1	1	1	Positive Genetic
TOM6	YOR045W	Component of the TOM (translocase of outer membrane) complex	genetic	1	1	1	Positive Genetic
UBP16	YPL072W	Deubiquitinating enzyme anchored to the outer mitochondrial membrane	genetic	1	1	1	Positive Genetic
SNT309	YPR101W	Member of the NineTeen Complex (NTC)	genetic	1	1	1	Positive Genetic
RFT1	YBL020W	Membrane protein required for translocation of Man5GlcNac2-PP-Dol	genetic	1	1	1	Negative Genetic
POL12	YBL035C	B subunit of DNA polymerase alpha-primase complex	genetic	1	1	1	Negative Genetic
RER2	YBR002C	Forms the dehydrodolichyl diphosphate synthase (DDS) complex with NUS1	genetic	1	1	1	Negative Genetic
NUS1	YDL193W	Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1	genetic	1	1	1	Negative Genetic
TFB1	YDR311W	Subunit of TFIIH and nucleotide excision repair factor 3 complexes	genetic	1	1	1	Negative Genetic
NCB2	YDR397C	Subunit of a heterodimeric NC2 transcription regulator complex	genetic	1	1	1	Negative Genetic
TLG1	YDR468C	Essential t-SNARE that mediates fusion of vesicles with the late Golgi	genetic	1	1	1	Negative Genetic
WBP1	YEL002C	Beta subunit of the oligosaccharyl transferase glycoprotein complex	genetic	1	1	1	Negative Genetic
PAB1	YER165W	Poly(A) binding protein	genetic	1	1	1	Negative Genetic
SEC4	YFL005W	Rab family GTPase	genetic	1	1	1	Negative Genetic
YPI1	YFR003C	Regulatory subunit of the type I protein phosphatase (PP1) Glc7p	genetic	1	1	1	Negative Genetic
SCL1	YGL011C	Alpha 1 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
RPS2	YGL123W	Protein component of the small (40S) subunit	genetic	1	1	1	Negative Genetic
SUA5	YGL169W	Protein involved in threonylcarbamoyl adenosine biosynthesis	genetic	1	1	1	Negative Genetic
PRP18	YGR006W	Splicing factor and component of snRNP U5	genetic	1	1	1	Negative Genetic
VHT1	YGR065C	High-affinity plasma membrane H+-biotin (vitamin H) symporter	genetic	1	1	1	Negative Genetic
UTP8	YGR128C	Nucleolar protein required for export of tRNAs from the nucleus	genetic	1	1	1	Negative Genetic
YIP1	YGR172C	Integral membrane protein	genetic	1	1	1	Negative Genetic
THS1	YIL078W	Threonyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
TAO3	YIL129C	Component of the RAM signaling network	genetic	1	1	1	Negative Genetic
SSL2	YIL143C	Component of RNA polymerase transcription factor TFIIH holoenzyme	genetic	1	1	1	Negative Genetic
TIM54	YJL054W	Component of the mitochondrial TIM22 complex	genetic	1	1	1	Negative Genetic
RFA3	YJL173C	Subunit of heterotrimeric Replication Protein A (RPA)	genetic	1	1	1	Negative Genetic
PRP21	YJL203W	Subunit of the SF3a splicing factor complex	genetic	1	1	1	Negative Genetic
URA6	YKL024C	Uridylate kinase	genetic	1	1	1	Negative Genetic
SPC42	YKL042W	Central plaque component of spindle pole body (SPB)	genetic	1	1	1	Negative Genetic
PRI2	YKL045W	Subunit of DNA primase	genetic	1	1	1	Negative Genetic
RLP24	YLR009W	Essential protein required for ribosomal large subunit biogenesis	genetic	1	1	1	Negative Genetic
STU2	YLR045C	Microtubule polymerase of the XMAP215/Dis1 family	genetic	1	1	1	Negative Genetic
SEC59	YMR013C	Dolichol kinase	genetic	1	1	1	Negative Genetic
RRB1	YMR131C	Specific assembly chaperone for ribosomal protein Rpl3p	genetic	1	1	1	Negative Genetic
TOP2	YNL088W	Topoisomerase II	genetic	1	1	1	Negative Genetic
PGA1	YNL158W	Essential component of GPI-mannosyltransferase II	genetic	1	1	1	Negative Genetic
PBR1	YNL181W	Putative oxidoreductase	genetic	1	1	1	Negative Genetic
PIK1	YNL267W	Phosphatidylinositol 4-kinase	genetic	1	1	1	Negative Genetic
RPB11	YOL005C	RNA polymerase II subunit B12.5	genetic	1	1	1	Negative Genetic
SMC5	YOL034W	Subunit of the SMC5-SMC6 complex	genetic	1	1	1	Negative Genetic
WRS1	YOL097C	Cytoplasmic tryptophanyl-tRNA synthetase	genetic	1	1	1	Negative Genetic
RPL3	YOR063W	Ribosomal 60S subunit protein L3	genetic	1	1	1	Negative Genetic
SEC63	YOR254C	Essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
SOG2	YOR353C	Key component of the RAM signaling network	genetic	1	1	1	Negative Genetic
TAF3	YPL011C	TFIID subunit (47 kDa)	genetic	1	1	1	Negative Genetic
TAH18	YPR048W	Conserved NAPDH-dependent diflavin reductase	genetic	1	1	1	Negative Genetic
SPN1	YPR133C	Protein involved in RNA polymerase II transcription	genetic	1	1	1	Negative Genetic
SGV1	YPR161C	Cyclin (Bur2p)-dependent protein kinase	genetic	1	1	1	Negative Genetic
ORC4	YPR162C	Subunit of the origin recognition complex (ORC)	genetic	1	1	1	Negative Genetic
SEC23	YPR181C	GTPase-activating protein, stimulates the GTPase activity of Sar1p	genetic	1	1	1	Negative Genetic
SMC4	YLR086W	Subunit of the condensin complex	genetic	1	1	1	Negative Genetic
ORC1	YML065W	Largest subunit of the origin recognition complex	genetic	1	1	1	Negative Genetic
SEC62	YPL094C	Essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
PRE2	YPR103W	Beta 5 subunit of the 20S proteasome	genetic	1	1	1	Negative Genetic
SFA1	YDL168W	Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase	genetic	1	1	1	Negative Genetic
PMT1	YDL095W	Protein O-mannosyltransferase of the ER membrane	genetic	1	1	1	Negative Genetic
OST4	YDL232W	Subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Negative Genetic
UBX2	YML013W	Bridging factor involved in ER-associated protein degradation (ERAD)	genetic	1	1	1	Negative Genetic
SIN3	YOL004W	Component of both the Rpd3S and Rpd3L histone deacetylase complexes	genetic	1	1	1	Negative Genetic
RTC1	YOL138C	Subunit of SEACAT, a subcomplex of the SEA complex	genetic	1	1	1	Negative Genetic
RUP1	YOR138C	Protein that regulates ubiquitination of Rsp5p	genetic	1	1	1	Negative Genetic
SSN2	YDR443C	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
VPS52	YDR484W	Component of the GARP (Golgi-associated retrograde protein) complex	genetic	1	1	1	Negative Genetic
YDR524C-B	YDR524C-B	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YDR524W-C	YDR524W-C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
VAC8	YEL013W	Vacuole-specific Myo2p receptor	genetic	1	1	1	Negative Genetic
PXP1	YEL020C	Peroxisomal matrix protein	genetic	1	1	1	Negative Genetic
TCA17	YEL048C	Component of transport protein particle (TRAPP) complex II	genetic	1	1	1	Negative Genetic
RPH1	YER169W	JmjC domain-containing histone demethylase	genetic	1	1	1	Negative Genetic
RPL1B	YGL135W	Ribosomal 60S subunit protein L1B	genetic	1	1	1	Negative Genetic
SPO74	YGL170C	Component of the meiotic outer plaque of the spindle pole body	genetic	1	1	1	Negative Genetic
RRT14	YIL127C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
SPC1	YJR010C-A	Subunit of the signal peptidase complex (SPC)	genetic	1	1	1	Negative Genetic
ZRT3	YKL175W	Vacuolar membrane zinc transporter	genetic	1	1	1	Negative Genetic
YLL006W-A	YLL006W-A	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
UBI4	YLL039C	Ubiquitin	genetic	1	1	1	Negative Genetic
YLR108C	YLR108C	Protein of unknown function	genetic	1	1	1	Negative Genetic
SPE4	YLR146C	Spermine synthase	genetic	1	1	1	Negative Genetic
RRG9	YNL213C	Protein of unknown function	genetic	1	1	1	Negative Genetic
SIN4	YNL236W	Subunit of the RNA polymerase II mediator complex	genetic	1	1	1	Negative Genetic
RPA49	YNL248C	RNA polymerase I subunit A49	genetic	1	1	1	Negative Genetic
YOL029C	YOL029C	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YOL162W	YOL162W	Putative protein of unknown function	genetic	1	1	1	Negative Genetic
YNG1	YOR064C	Subunit of the NuA3 histone acetyltransferase complex	genetic	1	1	1	Negative Genetic
REV1	YOR346W	Deoxycytidyl transferase	genetic	1	1	1	Negative Genetic
SWI3	YJL176C	Subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Negative Genetic
RAD23	YEL037C	Protein with ubiquitin-like N terminus	genetic	1	1	1	Positive Genetic
OCA1	YNL099C	Putative protein tyrosine phosphatase	genetic	1	1	1	Positive Genetic
SOD1	YJR104C	Cytosolic copper-zinc superoxide dismutase	genetic	1	1	1	Negative Genetic
NHX1	YDR456W	Na+/H+ and K+/H+ exchanger	genetic	1	1	1	Negative Genetic
XRN1	YGL173C	Evolutionarily-conserved 5'-3' exonuclease	genetic	1	1	1	Negative Genetic
SIW14	YNL032W	Inositol phosphatase involved in inositol pyrophosphate metabolism	genetic	1	1	1	Positive Genetic
RXT2	YBR095C	Component of the histone deacetylase Rpd3L complex	genetic	1	1	1	Negative Genetic
OCA2	YNL056W	Protein of unknown function	genetic	1	1	1	Positive Genetic
ROT2	YBR229C	Glucosidase II catalytic subunit	genetic	1	1	1	Negative Genetic
SPE1	YKL184W	Ornithine decarboxylase	genetic	1	1	1	Negative Genetic
VPS75	YNL246W	NAP family histone chaperone	genetic	1	1	1	Negative Genetic
RPC40	YPR110C	RNA polymerase subunit AC40	genetic	1	1	1	Negative Genetic
RPS19B	YNL302C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
YND1	YER005W	Apyrase with wide substrate specificity	genetic	1	1	1	Negative Genetic
SPE2	YOL052C	S-adenosylmethionine decarboxylase	genetic	1	1	1	Negative Genetic
PHO5	YBR093C	Repressible acid phosphatase	genetic	1	1	1	Negative Genetic
TUM1	YOR251C	Rhodanese domain sulfur transferase	genetic	1	1	1	Negative Genetic
RPS19A	YOL121C	Protein component of the small (40S) ribosomal subunit	genetic	1	1	1	Negative Genetic
SIC1	YLR079W	Cyclin-dependent kinase inhibitor (CKI)	genetic	1	1	1	Negative Genetic
SSN8	YNL025C	Cyclin-like component of RNA polymerase II holoenzyme	genetic	1	1	1	Negative Genetic
PTC3	YBL056W	Type 2C protein phosphatase (PP2C)	genetic	1	1	1	Negative Genetic
YPT1	YFL038C	Rab family GTPase	genetic	1	1	1	Negative Genetic
YPK9	YOR291W	Vacuolar protein with a possible role in sequestering heavy metals	genetic	1	1	1	Negative Genetic
UBA4	YHR111W	E1-like protein that activates Urm1p before urmylation	genetic	1	1	1	Negative Genetic
OCA4	YCR095C	Cytoplasmic protein required for replication of Brome mosaic virus	genetic	1	1	1	Positive Genetic
PKH3	YDR466W	Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p	genetic	1	1	1	Positive Genetic
TUB2	YFL037W	Beta-tubulin	genetic	1	1	1	Negative Genetic
SNF5	YBR289W	Subunit of the SWI/SNF chromatin remodeling complex	genetic	1	1	1	Negative Genetic
YMR315W	YMR315W	Protein with NADP(H) oxidoreductase activity	genetic	1	1	1	Negative Genetic
PMA1	YGL008C	Plasma membrane P2-type H+-ATPase	genetic	1	1	1	Negative Genetic
STU1	YBL034C	Microtubule plus-end-tracking non-motor protein	genetic	1	1	1	Positive Genetic
SEC17	YBL050W	Alpha-SNAP cochaperone	genetic	1	1	1	Negative Genetic
TSC3	YBR058C-A	Protein that stimulates the activity of serine palmitoyltransferase	genetic	1	1	1	Positive Genetic
YSY6	YBR162W-A	Protein of unknown function	genetic	1	1	1	Negative Genetic
SEC66	YBR171W	Non-essential subunit of Sec63 complex	genetic	1	1	1	Negative Genetic
RGD1	YBR260C	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p	genetic	1	1	1	Positive Genetic
RPN6	YDL097C	Essential, non-ATPase regulatory subunit of the 26S proteasome lid	genetic	1	1	1	Positive Genetic
NSE4	YDL105W	Component of the SMC5-SMC6 complex	genetic	1	1	1	Positive Genetic
VPS72	YDR485C	Htz1p-binding component of the SWR1 complex	genetic	1	1	1	Positive Genetic
YCK3	YER123W	Palmitoylated vacuolar membrane-localized casein kinase I isoform	genetic	1	1	1	Negative Genetic
SPT2	YER161C	Protein involved in negative regulation of transcription	genetic	1	1	1	Positive Genetic
NUP145	YGL092W	Essential protein with distinct roles in two nuclear pore subcomplexes	genetic	1	1	1	Positive Genetic
VPS73	YGL104C	Mitochondrial protein	genetic	1	1	1	Negative Genetic
ZPR1	YGR211W	Essential protein with two zinc fingers	genetic	1	1	1	Negative Genetic
YTA7	YGR270W	Chromatin-binding ATPase that regulates histone gene expression	genetic	1	1	1	Positive Genetic
SBP1	YHL034C	Protein that binds eIF4G and has a role in repression of translation	genetic	1	1	1	Positive Genetic
RPN1	YHR027C	Non-ATPase base subunit of the 19S RP of the 26S proteasome	genetic	1	1	1	Positive Genetic
RPN10	YHR200W	Proteasome polyubiquitin receptor	genetic	1	1	1	Positive Genetic
PAN1	YIR006C	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p	genetic	1	1	1	Positive Genetic
STS1	YIR011C	Protein required for localizing proteasomes to the nucleus	genetic	1	1	1	Positive Genetic
OST1	YJL002C	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Negative Genetic
RPC17	YJL011C	RNA polymerase III subunit C17	genetic	1	1	1	Negative Genetic
SNX4	YJL036W	Sorting nexin	genetic	1	1	1	Negative Genetic
NUC1	YJL208C	Major mitochondrial nuclease	genetic	1	1	1	Positive Genetic
RAV1	YJR033C	Subunit of RAVE complex (Rav1p, Rav2p, Skp1p)	genetic	1	1	1	Negative Genetic
VPS24	YKL041W	One of four subunits of the ESCRT-III complex	genetic	1	1	1	Negative Genetic
RPT1	YKL145W	ATPase of the 19S regulatory particle of the 26S proteasome	genetic	1	1	1	Positive Genetic
SAC1	YKL212W	Phosphatidylinositol phosphate phosphatase	genetic	1	1	1	Negative Genetic
SIS2	YKR072C	Negative regulatory subunit of protein phosphatase 1 (Ppz1p)	genetic	1	1	1	Negative Genetic
TAG1	YLR173W	Vacuolar membrane protein involved in termination of autophagy	genetic	1	1	1	Negative Genetic
PEX30	YLR324W	ER-resident protein involved in peroxisomal biogenesis	genetic	1	1	1	Positive Genetic
OST6	YML019W	Subunit of the oligosaccharyltransferase complex of the ER lumen	genetic	1	1	1	Negative Genetic
RAD52	YML032C	Protein involved in homologous recombination	genetic	1	1	1	Positive Genetic
SRC1	YML034W	Inner nuclear membrane protein	genetic	1	1	1	Positive Genetic
VPS71	YML041C	Nucleosome-binding component of the SWR1 complex	genetic	1	1	1	Positive Genetic
TAF8	YML114C	TFIID subunit (65 kDa)	genetic	1	1	1	Positive Genetic
VTI1	YMR197C	Protein involved in cis-Golgi membrane traffic	genetic	1	1	1	Positive Genetic
RCE1	YMR274C	Type II CAAX prenyl protease	genetic	1	1	1	Positive Genetic
PHO80	YOL001W	Cyclin	genetic	1	1	1	Positive Genetic
TRM10	YOL093W	tRNA methyltransferase	genetic	1	1	1	Positive Genetic
TIR2	YOR010C	Putative cell wall mannoprotein	genetic	1	1	1	Positive Genetic
VPS5	YOR069W	Nexin-1 homolog	genetic	1	1	1	Negative Genetic
VAM3	YOR106W	Syntaxin-like vacuolar t-SNARE	genetic	1	1	1	Negative Genetic
SLP1	YOR154W	Glycosylated integral ER membrane protein of unknown function	genetic	1	1	1	Negative Genetic
SNU66	YOR308C	Component of the U4/U6.U5 snRNP complex	genetic	1	1	1	Positive Genetic
TYE7	YOR344C	Serine-rich protein that contains a bHLH DNA binding motif	genetic	1	1	1	Positive Genetic
YPL071C	YPL071C	Putative protein of unknown function	genetic	1	1	1	Positive Genetic
RLM1	YPL089C	MADS-box transcription factor	genetic	1	1	1	Positive Genetic
RTC6	YPL183W-A	Protein involved in translation	genetic	1	1	1	Positive Genetic
NEW1	YPL226W	Translation termination and ribosome biogenesis factor	genetic	1	1	1	Positive Genetic
SSO1	YPL232W	Plasma membrane t-SNARE	genetic	1	1	1	Negative Genetic
RPN7	YPR108W	Essential non-ATPase regulatory subunit of the 26S proteasome	genetic	1	1	1	Positive Genetic
RET2	YFR051C	Delta subunit of the coatomer complex (COPI)	genetic	1	1	1	Positive Genetic
SWC4	YGR002C	Component of the Swr1p complex that incorporates Htz1p into chromatin	genetic	1	1	1	Positive Genetic
PRP8	YHR165C	Component of U4/U6-U5 snRNP complex	genetic	1	1	1	Negative Genetic
RRI2	YOL117W	Subunit of the COP9 signalosome (CSN) complex	genetic	1	1	1	Positive Genetic
SGT1	YOR057W	Cochaperone protein	genetic	1	1	1	Negative Genetic
YAR1	YPL239W	Nucleocytoplasmic shuttling assembly chaperone	genetic	1	1	1	Negative Genetic
SGS1	YMR190C	RecQ family nucleolar DNA helicase	genetic	1	1	1	Positive Genetic
CTK3	YML112W	Gamma subunit of C-terminal domain kinase I	genetic	1	1	1	Negative Genetic
CLN3	YAL040C	G1 cyclin involved in cell cycle progression	genetic	1	1	1	Negative Genetic
MCM10	YIL150C	Essential chromatin-associated protein	genetic	1	1	1	Negative Genetic
FAR3	YMR052W	Protein of unknown function	genetic	1	1	1	Negative Genetic
AFT1	YGL071W	Transcription factor involved in iron utilization and homeostasis	physical	1	1	1	Two-hybrid
IPK1	YDR315C	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase	genetic	1	1	1	Negative Genetic
IRE1	YHR079C	Serine-threonine kinase and endoribonuclease	genetic	1	1	1	Positive Genetic
LST7	YGR057C	Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p	genetic	1	1	1	Negative Genetic
GCN4	YEL009C	bZIP transcriptional activator of amino acid biosynthetic genes	genetic	1	1	1	Negative Genetic
CAK1	YFL029C	Cyclin-dependent kinase-activating kinase	genetic	1	1	1	Negative Genetic
NBA1	YOL070C	Protein involved in axial bud site selection	physical	1	1	1	Two-hybrid
KEG1	YFR042W	Integral membrane protein of the ER	genetic	1	1	1	Negative Genetic
MDY2	YOL111C	Protein involved in inserting tail-anchored proteins into ER membranes	genetic	1	1	1	Positive Genetic
COG4	YPR105C	Essential component of the conserved oligomeric Golgi complex	genetic	1	1	1	Negative Genetic
APC5	YOR249C	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C)	genetic	1	1	1	Negative Genetic
COG7	YGL005C	Component of the conserved oligomeric Golgi complex	genetic	1	1	1	Negative Genetic
DOC1	YGL240W	Processivity factor	genetic	1	1	1	Negative Genetic
GRC3	YLL035W	Polynucleotide kinase present on rDNA	genetic	1	1	1	Positive Genetic
CDC21	YOR074C	Thymidylate synthase	genetic	1	1	1	Negative Genetic
JIP5	YPR169W	Protein required for biogenesis of the large ribosomal subunit	genetic	1	1	1	Negative Genetic
IES3	YLR052W	Subunit of the INO80 chromatin remodeling complex	genetic	1	1	1	Negative Genetic
CSE4	YKL049C	Centromeric histone H3-like protein	physical	1	1	1	Affinity Capture-MS
CSE4	YKL049C	Centromeric histone H3-like protein	genetic	1	1	1	Negative Genetic
CTF8	YHR191C	Subunit of a complex with Ctf18p	genetic	1	1	1	Negative Genetic
DBP5	YOR046C	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family	genetic	1	1	1	Synthetic Lethality
FRQ1	YDR373W	N-myristoylated calcium-binding protein	genetic	1	1	1	Negative Genetic
GIM4	YEL003W	Subunit of the heterohexameric cochaperone prefoldin complex	genetic	1	1	1	Negative Genetic
MTH1	YDR277C	Negative regulator of the glucose-sensing signal transduction pathway	physical	1	1	1	Two-hybrid
CCZ1	YBR131W	Subunit of a heterodimeric guanine nucleotide exchange factor (GEF)	genetic	1	1	1	Negative Genetic
KTI11	YBL071W-A	Zn-ribbon protein that co-purifies with Dph1 and Dph2	genetic	1	1	1	Positive Genetic
GOS1	YHL031C	v-SNARE protein involved in Golgi transport	genetic	1	1	1	Negative Genetic
CCS1	YMR038C	Copper chaperone for superoxide dismutase Sod1p	genetic	1	1	1	Synthetic Growth Defect
BNR1	YIL159W	Formin	genetic	1	1	1	Negative Genetic
MCM7	YBR202W	Component of the Mcm2-7 hexameric helicase complex	genetic	1	1	1	Positive Genetic
DOT1	YDR440W	Nucleosomal histone H3-Lys79 methylase	genetic	1	1	1	Positive Genetic
MET31	YPL038W	Zinc-finger DNA-binding transcription factor	physical	1	1	1	Two-hybrid
AZF1	YOR113W	Zinc-finger transcription factor	genetic	1	1	1	Negative Genetic
ATP10	YLR393W	Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase	genetic	1	1	1	Negative Genetic
BSD2	YBR290W	Heavy metal ion homeostasis protein	genetic	1	1	1	Negative Genetic
HAC1	YFL031W	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog)	genetic	1	1	1	Positive Genetic
DID2	YKR035W-A	Class E protein of the vacuolar protein-sorting (Vps) pathway	genetic	1	1	1	Positive Genetic
ENT1	YDL161W	Epsin-like protein involved in endocytosis and actin patch assembly	genetic	1	1	1	Negative Genetic
ERV14	YGL054C	COPII-coated vesicle protein	genetic	1	1	1	Positive Genetic
MON2	YNL297C	Protein with a role in endocytosis and vacuole integrity	genetic	1	1	1	Negative Genetic
INP51	YIL002C	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase	genetic	1	1	1	Negative Genetic
CCC1	YLR220W	Vacuolar Fe2+/Mn2+ transporter	genetic	1	1	1	Negative Genetic
EPO1	YMR124W	Protein involved in septin-ER tethering	genetic	1	1	1	Synthetic Lethality
FMP27	YLR454W	Protein with structural similarity to lipid transport protein Vps13p	genetic	1	1	1	Negative Genetic
CNN1	YFR046C	Kinetochore protein	genetic	1	1	1	Positive Genetic
ATP18	YML081C-A	Subunit of the mitochondrial F1F0 ATP synthase	genetic	1	1	1	Negative Genetic
GEF1	YJR040W	Voltage-gated chloride channel	genetic	1	1	1	Negative Genetic
CUE4	YML101C	Protein of unknown function	genetic	1	1	1	Negative Genetic
ALG1	YBR110W	Mannosyltransferase	genetic	1	1	1	Negative Genetic
GDA1	YEL042W	Guanosine diphosphatase located in the Golgi	genetic	1	1	1	Negative Genetic
FAT1	YBR041W	Very long chain fatty acyl-CoA synthetase and fatty acid transporter	genetic	1	1	1	Positive Genetic
HRQ1	YDR291W	3'-5' DNA helicase of the conserved RecQ family	genetic	1	1	1	Positive Genetic
BPH1	YCR032W	Protein homologous to Chediak-Higashi syndrome and Beige proteins	genetic	1	1	1	Negative Genetic
AHK1	YDL073W	Scaffold protein in the HKR1 sub-branch of the Hog1p-signaling pathway	genetic	1	1	1	Negative Genetic
GCD14	YJL125C	Subunit of tRNA (1-methyladenosine) methyltransferase	genetic	1	1	1	Negative Genetic
AQY3	YFL054C	Putative channel-like protein	genetic	1	1	1	Positive Genetic
AIM26	YKL037W	Protein of unknown function	genetic	1	1	1	Negative Genetic
GIS2	YNL255C	Translational activator for mRNAs with internal ribosome entry sites	physical	1	1	1	Affinity Capture-RNA
MSB1	YOR188W	Protein of unknown function	genetic	1	1	1	Dosage Rescue
GSH1	YJL101C	Gamma glutamylcysteine synthetase	genetic	1	1	1	Negative Genetic
ARO2	YGL148W	Bifunctional chorismate synthase and flavin reductase	genetic	1	1	1	Negative Genetic
AGE2	YIL044C	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector	genetic	1	1	1	Negative Genetic
GPI12	YMR281W	ER membrane protein involved in the second step of GPI anchor assembly	genetic	1	1	1	Negative Genetic
ENT4	YLL038C	Protein of unknown function	genetic	1	1	1	Positive Genetic
EMC4	YGL231C	Member of conserved ER transmembrane complex	genetic	1	1	1	Negative Genetic
GAS3	YMR215W	Putative 1,3-beta-glucanosyltransferase	genetic	1	1	1	Negative Genetic
HUR1	YGL168W	Protein with a role in DNA repair	genetic	1	1	1	Negative Genetic
EOS1	YNL080C	Protein involved in N-glycosylation	genetic	1	1	1	Negative Genetic
MTM1	YGR257C	Mitochondrial protein of the mitochondrial carrier family	genetic	1	1	1	Positive Genetic
CWH43	YCR017C	GPI lipid remodelase	genetic	1	1	1	Negative Genetic
GPI19	YDR437W	Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI	genetic	1	1	1	Negative Genetic
DER1	YBR201W	ER membrane protein that promotes export of misfolded polypeptides	genetic	1	1	1	Negative Genetic
CDC50	YCR094W	Endosomal protein that interacts with phospholipid flippase Drs2p	genetic	1	1	1	Positive Genetic
EST2	YLR318W	Reverse transcriptase subunit of the telomerase holoenzyme	genetic	1	1	1	Negative Genetic
COQ2	YNR041C	Para hydroxybenzoate polyprenyl transferase	genetic	1	1	1	Positive Genetic
CHS2	YBR038W	Chitin synthase II	genetic	1	1	1	Negative Genetic
MET7	YOR241W	Folylpolyglutamate synthetase	genetic	1	1	1	Negative Genetic
GOT1	YMR292W	Homodimeric protein that is packaged into COPII vesicles	genetic	1	1	1	Positive Genetic
ILM1	YJR118C	Protein of unknown function	genetic	1	1	1	Negative Genetic
CEM1	YER061C	Mitochondrial beta-keto-acyl synthase	genetic	1	1	1	Positive Genetic
CGR1	YGL029W	Protein involved in nucleolar integrity and processing of pre-rRNA	genetic	1	1	1	Positive Genetic
DYN3	YMR299C	Dynein light intermediate chain (LIC)	physical	1	1	1	Two-hybrid
CHO2	YGR157W	Phosphatidylethanolamine methyltransferase (PEMT)	genetic	1	1	1	Negative Genetic
GPI13	YLL031C	ER membrane localized phosphoryltransferase	genetic	1	1	1	Negative Genetic
CDS1	YBR029C	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase)	genetic	1	1	1	Positive Genetic
BRR6	YGL247W	Essential nuclear envelope integral membrane protein	genetic	1	1	1	Negative Genetic
GPI14	YJR013W	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I	genetic	1	1	1	Negative Genetic
AIM14	YGL160W	NADPH oxidase localized to the perinuclear ER	genetic	1	1	1	Positive Genetic
IFM1	YOL023W	Mitochondrial translation initiation factor 2	genetic	1	1	1	Positive Genetic
DNF3	YMR162C	Trans-golgi network aminophospholipid translocase (flippase)	genetic	1	1	1	Negative Genetic
MIC12	YBR262C	Component of the MICOS complex	genetic	1	1	1	Positive Genetic
MRM2	YGL136C	Mitochondrial 2' O-ribose methyltransferase	genetic	1	1	1	Positive Genetic
GLD1	YPR109W	Component of Dsc E3 ligase complex in Golgi and endosomes	genetic	1	1	1	Negative Genetic
CRD1	YDL142C	Cardiolipin synthase	genetic	1	1	1	Synthetic Lethality
MSM1	YGR171C	Mitochondrial methionyl-tRNA synthetase (MetRS)	genetic	1	1	1	Negative Genetic
DGK1	YOR311C	Diacylglycerol kinase	genetic	1	1	1	Positive Genetic
EMC2	YJR088C	Member of conserved ER transmembrane complex	genetic	1	1	1	Negative Genetic
AIM33	YML087C	Protein of unknown function, highly conserved across species	genetic	1	1	1	Positive Genetic
AIF1	YNR074C	Mitochondrial cell death effector	genetic	1	1	1	Negative Genetic
ICE2	YIL090W	Integral ER membrane protein with type-III transmembrane domains	genetic	1	1	1	Synthetic Growth Defect
DBR1	YKL149C	RNA lariat debranching enzyme	genetic	1	1	1	Negative Genetic
KCH1	YJR054W	Potassium transporter that mediates K+ influx	genetic	1	1	1	Positive Genetic
GRE1	YPL223C	Hydrophilin essential in desiccation-rehydration process	genetic	1	1	1	Synthetic Rescue