Standard name Systematic name Name description Description
SCH9 YHR205W AGC family protein kinase AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan
Visualize the interactome of SCH9
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 154

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.919 0.927 0.885
Vac/Vac Memb 0.097 0.073 0.122

GFP localization & abundance

GFP localization GFP abundance
cytoplasm 3850

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SCH9 10 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAS2 YNL098C GTP-binding protein genetic 10 4 10 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 9 4 7 Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 8 4 5 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Suppression
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III physical 8 2 5 Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
TOR1 YJR066W PIK-related protein kinase and rapamycin target physical 5 1 5 Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 4 4 2 Dosage Rescue, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
STB3 YDR169C Ribosomal RNA processing element (RRPE)-binding protein genetic 4 4 2 Dosage Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 3 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 3 3 3 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 3 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect
SOD2 YHR008C Mitochondrial manganese superoxide dismutase genetic 3 3 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect
CDC73 YLR418C Component of the Paf1p complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 3 2 3 Dosage Rescue, Dosage Rescue, Negative Genetic
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPL11B YGR085C Ribosomal 60S subunit protein L11B genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
MSN4 YKL062W Stress-responsive transcriptional activator genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes genetic 3 2 3 Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect
GIS1 YDR096W Histone demethylase and transcription factor genetic 3 2 3 Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 3 2 3 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 3 2 Phenotypic Suppression, Synthetic Rescue, Negative Genetic
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex genetic 3 3 2 Phenotypic Enhancement, Synthetic Lethality, Negative Genetic
CYT1 YOR065W Cytochrome c1 genetic 3 3 2 Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect
GPA2 YER020W Nucleotide binding alpha subunit of the heterotrimeric G protein genetic 3 2 2 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
IRA1 YBR140C GTPase-activating protein genetic 3 2 2 Dosage Rescue, Dosage Rescue, Negative Genetic
PKH1 YDR490C Serine/threonine protein kinase physical 3 2 2 Biochemical Activity, Reconstituted Complex, Biochemical Activity
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 2 2 Phenotypic Suppression, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 2 2 2 Negative Genetic, Dosage Lethality
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
GCN3 YKR026C Alpha subunit of translation initiation factor eIF2B genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HDA3 YPR179C Subunit of HDA1 histone deacetylase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MSH2 YOL090W Protein that binds to DNA mismatches genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Dosage Rescue, Synthetic Rescue
PHO85 YPL031C Cyclin-dependent kinase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
DSS1 YMR287C 3'-5' exoribonuclease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CYS3 YAL012W Cystathionine gamma-lyase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
DCK1 YLR422W Dock family protein (Dedicator Of CytoKinesis), homolog of human DOCK1 genetic 2 2 2 Positive Genetic, Synthetic Lethality
RPL9B YNL067W Ribosomal 60S subunit protein L9B genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IES3 YLR052W Subunit of the INO80 chromatin remodeling complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PLC1 YPL268W Phospholipase C genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RTG2 YGL252C Sensor of mitochondrial dysfunction genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
HSF1 YGL073W Trimeric heat shock transcription factor genetic 2 2 2 Synthetic Rescue, Positive Genetic
GPR1 YDL035C Plasma membrane G protein coupled receptor (GPCR) genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 2 2 Co-purification, Affinity Capture-Western
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
TOS7 YOL019W Protein involved in secretion and cell wall organization genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 2 2 2 Phenotypic Suppression, Negative Genetic
YPT7 YML001W Rab family GTPase genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
SUB1 YMR039C Transcriptional regulator genetic 2 2 2 Synthetic Rescue, Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
TIF2 YJL138C Translation initiation factor eIF4A genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SST2 YLR452C GTPase-activating protein for Gpa1p genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RGM1 YMR182C Putative zinc finger DNA binding transcription factor genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
ARO7 YPR060C Chorismate mutase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RPE1 YJL121C D-ribulose-5-phosphate 3-epimerase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PDE2 YOR360C High-affinity cyclic AMP phosphodiesterase genetic 2 2 2 Dosage Rescue, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 2 1 2 Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 1 2 Negative Genetic, Negative Genetic
MSN2 YMR037C Stress-responsive transcriptional activator genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 2 1 2 Negative Genetic, Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
TPK1 YJL164C cAMP-dependent protein kinase catalytic subunit genetic 2 1 2 Dosage Rescue, Dosage Rescue
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 2 1 2 Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 2 1 2 Positive Genetic, Positive Genetic
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Positive Genetic, Positive Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 1 2 Negative Genetic, Negative Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 1 2 Negative Genetic, Negative Genetic
HSF1 YGL073W Trimeric heat shock transcription factor regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 2 1 Positive Genetic, Negative Genetic
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients physical 2 2 1 Affinity Capture-Western, Biochemical Activity
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
BUD32 YGR262C Protein kinase physical 2 2 1 Affinity Capture-Western, Biochemical Activity
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family physical 2 2 1 Reconstituted Complex, Biochemical Activity
HAP4 YKL109W Transcription factor genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
SKO1 YNL167C Basic leucine zipper transcription factor of the ATF/CREB family physical 2 2 1 Affinity Capture-Western, Biochemical Activity
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NCR1 YPL006W Vacuolar membrane protein involved with Npc2p in sterol trafficking genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 2 2 1 Phenotypic Suppression, Phenotypic Enhancement
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 2 1 1 Reconstituted Complex, Reconstituted Complex
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane genetic 2 1 1 Synthetic Rescue, Synthetic Rescue
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VMA16 YHR026W Subunit c'' of the vacuolar ATPase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
STE12 YHR084W Transcription factor that is activated by a MAPK signaling cascade regulation 1 1 1 chromatin immunoprecipitation-chip evidence
NPR1 YNL183C Protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
NPR2 YEL062W Subunit of the Iml1p/SEACIT complex regulation 1 1 1 qualitative western immunoblotting evidence
SNF1 YDR477W AMP-activated S/T protein kinase regulation 1 1 1 qualitative western immunoblotting evidence
TOR1 YJR066W PIK-related protein kinase and rapamycin target regulation 1 1 1 qualitative western immunoblotting evidence
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III regulation 1 1 1 qualitative western immunoblotting evidence
HHT2 YNL031C Histone H3 regulation 1 1 1 qualitative western immunoblotting evidence
HHT1 YBR010W Histone H3 regulation 1 1 1 qualitative western immunoblotting evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Negative Genetic
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Synthetic Growth Defect
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 1 1 1 Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Reconstituted Complex
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Positive Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
DBP9 YLR276C DEAD-box protein required for 27S rRNA processing genetic 1 1 1 Negative Genetic
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly genetic 1 1 1 Negative Genetic
IPI1 YHR085W Component of the Rix1 complex and possibly pre-replicative complexes genetic 1 1 1 Positive Genetic
ADH1 YOL086C Alcohol dehydrogenase genetic 1 1 1 Synthetic Growth Defect
PRP8 YHR165C Component of U4/U6-U5 snRNP complex genetic 1 1 1 Phenotypic Enhancement
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
DBP7 YKR024C Putative ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Synthetic Growth Defect
NAT3 YPR131C Catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Synthetic Growth Defect
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 1 1 1 Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
RRP4 YHR069C Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Synthetic Growth Defect
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Positive Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Synthetic Growth Defect
HPR1 YDR138W Subunit of THO/TREX complexes genetic 1 1 1 Phenotypic Suppression
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Synthetic Growth Defect
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Synthetic Growth Defect
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Synthetic Growth Defect
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Synthetic Growth Defect
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Positive Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Synthetic Growth Defect
BDF1 YLR399C BET family transcriptional regulator genetic 1 1 1 Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
NOG2 YNR053C Putative GTPase genetic 1 1 1 Negative Genetic
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Dosage Rescue
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
EMG1 YLR186W Methyltransferase for rRNA genetic 1 1 1 Negative Genetic
GCN2 YDR283C Protein kinase physical 1 1 1 Reconstituted Complex
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
GDI1 YER136W GDP dissociation inhibitor genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Negative Genetic
HAP2 YGL237C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Synthetic Growth Defect
HAT1 YPL001W Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex genetic 1 1 1 Positive Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
KGD1 YIL125W Subunit of the mitochondrial alpha-ketoglutarate dehydrogenase complex genetic 1 1 1 Synthetic Growth Defect
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
GAL11 YOL051W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 1 1 1 Synthetic Growth Defect
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
IMG2 YCR071C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRPL24 YMR193W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MRP51 YPL118W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Synthetic Growth Defect
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Negative Genetic
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Negative Genetic
MRPL3 YMR024W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
NUP159 YIL115C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
PDB1 YBR221C E1 beta subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Phenotypic Suppression
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Positive Genetic
PPH22 YDL188C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Synthetic Rescue
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
PRP4 YPR178W Splicing factor genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Synthetic Growth Defect
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Synthetic Growth Defect
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Synthetic Growth Defect
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Negative Genetic
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Synthetic Growth Defect
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase genetic 1 1 1 Synthetic Growth Defect
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Synthetic Growth Defect
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
NUT2 YPR168W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Synthetic Growth Defect
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
ADE3 YGR204W Cytoplasmic trifunctional enzyme genetic 1 1 1 Synthetic Growth Defect
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 1 1 1 Synthetic Growth Defect
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
ABF2 YMR072W Mitochondrial DNA-binding protein genetic 1 1 1 Synthetic Growth Defect
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Positive Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Positive Genetic
SAK1 YER129W Upstream serine/threonine kinase for the SNF1 complex genetic 1 1 1 Negative Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Synthetic Growth Defect
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
MRPL23 YOR150W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
HSE1 YHL002W Subunit of the endosomal Vps27p-Hse1p complex genetic 1 1 1 Synthetic Growth Defect
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Synthetic Growth Defect
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Phenotypic Suppression
DRS2 YAL026C Trans-golgi network aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
RSM7 YJR113C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
DOT6 YER088C Protein involved in rRNA and ribosome biogenesis physical 1 1 1 Biochemical Activity
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Synthetic Growth Defect
AKL1 YBR059C Ser/Thr protein kinase genetic 1 1 1 Positive Genetic
FAR7 YFR008W Protein involved in recovery from pheromone-induced cell cycle arrest genetic 1 1 1 Positive Genetic
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Synthetic Growth Defect
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Negative Genetic
PPQ1 YPL179W Protein phosphatase that regulates the mating response genetic 1 1 1 Negative Genetic
GSP1 YLR293C Ran GTPase genetic 1 1 1 Positive Genetic
FAA4 YMR246W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Positive Genetic
RHO5 YNL180C Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Lethality
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Positive Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Phenotypic Enhancement
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Positive Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
PHO81 YGR233C Cyclin-dependent kinase (CDK) inhibitor genetic 1 1 1 Synthetic Growth Defect
PKH2 YOL100W Serine/threonine protein kinase physical 1 1 1 Reconstituted Complex
PKH2 YOL100W Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
GPD2 YOL059W NAD-dependent glycerol 3-phosphate dehydrogenase genetic 1 1 1 Phenotypic Suppression
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase genetic 1 1 1 Phenotypic Suppression
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Synthetic Growth Defect
RAS1 YOR101W GTPase involved in G-protein signaling in adenylate cyclase activation genetic 1 1 1 Negative Genetic
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Growth Defect
ERG27 YLR100W 3-keto sterol reductase genetic 1 1 1 Positive Genetic
AYR1 YIL124W Bifunctional triacylglycerol lipase and 1-acyl DHAP reductase genetic 1 1 1 Negative Genetic
PSR1 YLL010C Plasma membrane-associated protein phosphatase genetic 1 1 1 Negative Genetic
KRE6 YPR159W Glucosyl hydrolase required for beta-1,6-glucan biosynthesis genetic 1 1 1 Synthetic Growth Defect
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 1 1 1 Synthetic Growth Defect
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 1 1 1 Synthetic Growth Defect
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Synthetic Growth Defect
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Synthetic Growth Defect
BUD32 YGR262C Protein kinase genetic 1 1 1 Synthetic Lethality
BUL1 YMR275C Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex genetic 1 1 1 Synthetic Growth Defect
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 1 1 1 Synthetic Growth Defect
MET6 YER091C Cobalamin-independent methionine synthase genetic 1 1 1 Synthetic Growth Defect
CBP3 YPL215W Mitochondrial protein required for assembly of cytochrome bc1 complex genetic 1 1 1 Synthetic Growth Defect
RAD24 YER173W Checkpoint protein genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-Western
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation genetic 1 1 1 Negative Genetic
GIS4 YML006C CAAX box containing protein of unknown function genetic 1 1 1 Synthetic Growth Defect
CHS1 YNL192W Chitin synthase I genetic 1 1 1 Synthetic Growth Defect
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Biochemical Activity
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Growth Defect
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) genetic 1 1 1 Negative Genetic
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Phenotypic Enhancement
MNN9 YPL050C Subunit of Golgi mannosyltransferase complex genetic 1 1 1 Synthetic Growth Defect
OPY1 YBR129C Protein of unknown function genetic 1 1 1 Negative Genetic
LSC1 YOR142W Alpha subunit of succinyl-CoA ligase genetic 1 1 1 Negative Genetic
HAL5 YJL165C Snf1p-related nutrient-responsive protein kinase genetic 1 1 1 Synthetic Growth Defect
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Synthetic Growth Defect
FAL1 YDR021W Nucleolar protein required for maturation of 18S rRNA genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
CPA1 YOR303W Small subunit of carbamoyl phosphate synthetase genetic 1 1 1 Synthetic Growth Defect
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Synthetic Growth Defect
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Negative Genetic
LEM3 YNL323W Membrane protein of the plasma membrane and ER genetic 1 1 1 Synthetic Growth Defect
GPA1 YHR005C Subunit of G protein involved in pheromone response genetic 1 1 1 Synthetic Growth Defect
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Positive Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Negative Genetic
MDJ1 YFL016C Co-chaperone that stimulates HSP70 protein Ssc1p ATPase activity genetic 1 1 1 Synthetic Growth Defect
ARG1 YOL058W Arginosuccinate synthetase genetic 1 1 1 Synthetic Growth Defect
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
RIM11 YMR139W Protein kinase genetic 1 1 1 Negative Genetic
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase genetic 1 1 1 Synthetic Growth Defect
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Affinity Capture-MS
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
BUD27 YFL023W Unconventional prefoldin protein involved in translation initiation genetic 1 1 1 Synthetic Growth Defect
LAC1 YKL008C Ceramide synthase component genetic 1 1 1 Dosage Growth Defect
ARG3 YJL088W Ornithine carbamoyltransferase genetic 1 1 1 Synthetic Growth Defect
FAR3 YMR052W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GNA1 YFL017C Glucosamine-6-phosphate acetyltransferase genetic 1 1 1 Negative Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Phenotypic Suppression
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Synthetic Growth Defect
INO2 YDR123C Transcription factor genetic 1 1 1 Synthetic Growth Defect
IBA57 YJR122W Protein involved in incorporating iron-sulfur clusters into proteins genetic 1 1 1 Synthetic Growth Defect
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Synthetic Growth Defect
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
MTF1 YMR228W Mitochondrial RNA polymerase specificity factor genetic 1 1 1 Synthetic Growth Defect
ATG36 YJL185C Pex3p interacting protein, required for pexophagy genetic 1 1 1 Synthetic Growth Defect
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Negative Genetic
PEP12 YOR036W Target membrane receptor (t-SNARE) genetic 1 1 1 Synthetic Growth Defect
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Negative Genetic
NOT5 YPR072W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Synthetic Growth Defect
BDP1 YNL039W Essential subunit of RNA polymerase III transcription factor (TFIIIB) physical 1 1 1 Biochemical Activity
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Reconstituted Complex
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Synthetic Growth Defect
RPS11A YDR025W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Synthetic Growth Defect
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes genetic 1 1 1 Synthetic Growth Defect
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Synthetic Growth Defect
COX18 YGR062C Protein required for membrane insertion of C-terminus of Cox2p genetic 1 1 1 Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 1 1 1 Synthetic Growth Defect
ELO3 YLR372W Elongase genetic 1 1 1 Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor genetic 1 1 1 Negative Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
BET1 YIL004C Type II membrane protein required for vesicular transport genetic 1 1 1 Positive Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase physical 1 1 1 Reconstituted Complex
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Growth Defect
MGM1 YOR211C Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p genetic 1 1 1 Synthetic Growth Defect
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 1 1 1 Synthetic Growth Defect
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Synthetic Growth Defect
PET123 YOR158W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
HSF1 YGL073W Trimeric heat shock transcription factor physical 1 1 1 Biochemical Activity
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Negative Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Growth Defect
RRN7 YJL025W Component of the core factor (CF) rDNA transcription factor complex genetic 1 1 1 Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
GPB2 YAL056W Multistep regulator of cAMP-PKA signaling genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Synthetic Growth Defect
ATP10 YLR393W Assembly factor for the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
PFY1 YOR122C Profilin genetic 1 1 1 Positive Genetic
GTT1 YIR038C ER associated glutathione S-transferase genetic 1 1 1 Negative Genetic
GAT1 YFL021W Transcriptional activator of nitrogen catabolite repression genes genetic 1 1 1 Synthetic Growth Defect
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Negative Genetic
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Synthetic Growth Defect
PMT3 YOR321W Protein O-mannosyltransferase genetic 1 1 1 Negative Genetic
ETT1 YOR051C Nuclear protein that inhibits replication of Brome mosaic virus genetic 1 1 1 Synthetic Growth Defect
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Rescue
DBP6 YNR038W Essential protein involved in ribosome biogenesis genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Growth Defect
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
ERG28 YER044C Endoplasmic reticulum membrane protein genetic 1 1 1 Synthetic Growth Defect
MDM31 YHR194W Mitochondrial protein that may have a role in phospholipid metabolism genetic 1 1 1 Synthetic Growth Defect
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Synthetic Growth Defect
RPL7A YGL076C Ribosomal 60S subunit protein L7A genetic 1 1 1 Synthetic Growth Defect
RPL19B YBL027W Ribosomal 60S subunit protein L19B genetic 1 1 1 Negative Genetic
MEU1 YLR017W Methylthioadenosine phosphorylase (MTAP) genetic 1 1 1 Positive Genetic
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Synthetic Rescue
ATP17 YDR377W Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
HCM1 YCR065W Forkhead transcription factor physical 1 1 1 Biochemical Activity
BTS1 YPL069C Geranylgeranyl diphosphate synthase (GGPPS) genetic 1 1 1 Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
HEM14 YER014W Protoporphyrinogen oxidase genetic 1 1 1 Synthetic Growth Defect
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes genetic 1 1 1 Synthetic Growth Defect
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Synthetic Growth Defect
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
GAS5 YOL030W 1,3-beta-glucanosyltransferase genetic 1 1 1 Synthetic Growth Defect
ATP14 YLR295C Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
ATP15 YPL271W Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Synthetic Growth Defect
OCH1 YGL038C Mannosyltransferase of the cis-Golgi apparatus genetic 1 1 1 Synthetic Growth Defect
ALG3 YBL082C Dolichol-P-Man dependent alpha(1-3) mannosyltransferase genetic 1 1 1 Negative Genetic
SAT4 YCR008W Ser/Thr protein kinase involved in salt tolerance, nutrient response genetic 1 1 1 Synthetic Growth Defect
BUD23 YCR047C Ribosome biogenesis factor genetic 1 1 1 Synthetic Growth Defect
FRE3 YOR381W Ferric reductase genetic 1 1 1 Synthetic Growth Defect
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Synthetic Growth Defect
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MRPL17 YNL252C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
JIP4 YDR475C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
MRPS8 YMR158W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Synthetic Growth Defect
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Synthetic Growth Defect
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase physical 1 1 1 Reconstituted Complex
MTG1 YMR097C Putative GTPase peripheral to the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
NKP2 YLR315W Central kinetochore protein and subunit of the Ctf19 complex genetic 1 1 1 Negative Genetic
IMP21 YIL154C Transcriptional activator involved in maintenance of ion homeostasis genetic 1 1 1 Synthetic Growth Defect
MSC7 YHR039C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
HOB2 YPR117W Protein with structural similarity to lipid transport protein Vps13p genetic 1 1 1 Negative Genetic
CYB5 YNL111C Cytochrome b5 genetic 1 1 1 Synthetic Growth Defect
ADH7 YCR105W NADPH-dependent medium chain alcohol dehydrogenase genetic 1 1 1 Synthetic Growth Defect
MEF2 YJL102W Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Synthetic Growth Defect
RPP1A YDL081C Ribosomal stalk protein P1 alpha genetic 1 1 1 Negative Genetic
MBR1 YKL093W Protein involved in mitochondrial functions and stress response genetic 1 1 1 Dosage Rescue
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Synthetic Growth Defect
NAM2 YLR382C Mitochondrial leucyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Synthetic Growth Defect
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Growth Defect
MRPL22 YNL177C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
ISM1 YPL040C Mitochondrial isoleucyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Growth Defect
RIM4 YHL024W Putative RNA-binding protein physical 1 1 1 Reconstituted Complex
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL13B YMR142C Ribosomal 60S subunit protein L13B genetic 1 1 1 Synthetic Growth Defect
RPS16A YMR143W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS14B YJL191W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
GSH1 YJL101C Gamma glutamylcysteine synthetase genetic 1 1 1 Synthetic Growth Defect
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Reconstituted Complex
FYV6 YNL133C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Positive Genetic
FPS1 YLL043W Aquaglyceroporin, plasma membrane channel genetic 1 1 1 Synthetic Growth Defect
LAG1 YHL003C Ceramide synthase component genetic 1 1 1 Dosage Growth Defect
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Synthetic Growth Defect
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Synthetic Growth Defect
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
TOS3 YGL179C Protein kinase physical 1 1 1 Biochemical Activity
SKY1 YMR216C SR protein kinase (SRPK) physical 1 1 1 Reconstituted Complex
UBC8 YEL012W Ubiquitin-conjugating enzyme that regulates gluconeogenesis physical 1 1 1 Reconstituted Complex
WWM1 YFL010C WW domain containing protein of unknown function physical 1 1 1 Reconstituted Complex
YMR196W YMR196W Putative protein of unknown function physical 1 1 1 Reconstituted Complex
TOD6 YBL054W PAC motif binding protein involved in rRNA and ribosome biogenesis physical 1 1 1 Biochemical Activity
STB3 YDR169C Ribosomal RNA processing element (RRPE)-binding protein physical 1 1 1 Biochemical Activity
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 physical 1 1 1 Reconstituted Complex
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth physical 1 1 1 Affinity Capture-Western
ZDS1 YMR273C Protein with a role in regulating Swe1p-dependent polarized growth genetic 1 1 1 Phenotypic Suppression
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Phenotypic Suppression
SCH9 YHR205W AGC family protein kinase physical 1 1 1 Biochemical Activity
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-Western
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Affinity Capture-Western
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone genetic 1 1 1 Phenotypic Suppression
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 1 1 1 Synthetic Rescue
YAK1 YJL141C Serine-threonine protein kinase genetic 1 1 1 Phenotypic Enhancement
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 1 1 1 Positive Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
SKM1 YOL113W Member of the PAK family of serine/threonine protein kinases genetic 1 1 1 Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Synthetic Rescue
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Phenotypic Enhancement
TAT1 YBR069C Amino acid transporter for valine, leucine, isoleucine, and tyrosine genetic 1 1 1 Negative Genetic
WSC3 YOL105C Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway genetic 1 1 1 Negative Genetic
TCB2 YNL087W ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Synthetic Rescue
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Synthetic Rescue
YPC1 YBR183W Alkaline ceramidase genetic 1 1 1 Synthetic Growth Defect
YDC1 YPL087W Alkaline dihydroceramidase, involved in sphingolipid metabolism genetic 1 1 1 Synthetic Growth Defect
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Negative Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Positive Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Negative Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Negative Genetic
VAC17 YCL063W Phosphoprotein involved in vacuole inheritance genetic 1 1 1 Synthetic Rescue
UTP9 YHR196W Nucleolar protein genetic 1 1 1 Phenotypic Enhancement
UTP22 YGR090W Component of the small-subunit processome genetic 1 1 1 Dosage Growth Defect
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Positive Genetic
UTP6 YDR449C Nucleolar protein genetic 1 1 1 Positive Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 1 1 1 Positive Genetic
SMC4 YLR086W Subunit of the condensin complex genetic 1 1 1 Positive Genetic
SEC62 YPL094C Essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Positive Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Positive Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
YHM2 YMR241W Citrate and oxoglutarate carrier protein genetic 1 1 1 Positive Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Positive Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
SPC110 YDR356W Inner plaque spindle pole body (SPB) component genetic 1 1 1 Negative Genetic
SYF1 YDR416W Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Negative Genetic
ZPR1 YGR211W Essential protein with two zinc fingers genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
SSL1 YLR005W Subunit of the core form of RNA polymerase transcription factor TFIIH genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
TAF8 YML114C TFIID subunit (65 kDa) genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Negative Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Negative Genetic
TIP1 YBR067C Major cell wall mannoprotein with possible lipase activity genetic 1 1 1 Negative Genetic
TEF2 YBR118W Translational elongation factor EF-1 alpha genetic 1 1 1 Negative Genetic
YBR197C YBR197C Protein of unknown function genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
YGR035C YGR035C Putative protein of unknown function, potential Cdc28p substrate genetic 1 1 1 Negative Genetic
YGR050C YGR050C Protein of unknown function genetic 1 1 1 Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YJR084W YJR084W Protein that forms a complex with Thp3p genetic 1 1 1 Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Negative Genetic
TIF1 YKR059W Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
UBI4 YLL039C Ubiquitin genetic 1 1 1 Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Negative Genetic
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Negative Genetic
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 1 1 1 Negative Genetic
YNL140C YNL140C Protein of unknown function genetic 1 1 1 Negative Genetic
TKL1 YPR074C Transketolase genetic 1 1 1 Negative Genetic
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase genetic 1 1 1 Synthetic Growth Defect
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Synthetic Growth Defect
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) genetic 1 1 1 Synthetic Growth Defect
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Growth Defect
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain genetic 1 1 1 Synthetic Growth Defect
SCP1 YOR367W Component of yeast cortical actin cytoskeleton genetic 1 1 1 Synthetic Growth Defect
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Synthetic Growth Defect
SCW4 YGR279C Cell wall protein with similarity to glucanases genetic 1 1 1 Synthetic Growth Defect
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Synthetic Growth Defect
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Synthetic Growth Defect
SGN1 YIR001C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SIT4 YDL047W Ceramide-activated, type 2A-related serine-threonine phosphatase genetic 1 1 1 Synthetic Growth Defect
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
SOV1 YMR066W Mitochondrial protein of unknown function genetic 1 1 1 Synthetic Growth Defect
SPO74 YGL170C Component of the meiotic outer plaque of the spindle pole body genetic 1 1 1 Synthetic Growth Defect
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Growth Defect
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Growth Defect
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Synthetic Growth Defect
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
SSQ1 YLR369W Mitochondrial hsp70-type molecular chaperone genetic 1 1 1 Synthetic Growth Defect
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Synthetic Growth Defect
STB5 YHR178W Transcription factor genetic 1 1 1 Synthetic Growth Defect
STM1 YLR150W Protein required for optimal translation under nutrient stress genetic 1 1 1 Synthetic Growth Defect
STP2 YHR006W Transcription factor genetic 1 1 1 Synthetic Growth Defect
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Synthetic Growth Defect
TAT2 YOL020W High affinity tryptophan and tyrosine permease genetic 1 1 1 Synthetic Growth Defect
TDA3 YHR009C Putative oxidoreductase involved in late endosome to Golgi transport genetic 1 1 1 Synthetic Growth Defect
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Synthetic Growth Defect
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Synthetic Growth Defect
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Synthetic Growth Defect
THR1 YHR025W Homoserine kinase genetic 1 1 1 Synthetic Growth Defect
TIF3 YPR163C Translation initiation factor eIF-4B genetic 1 1 1 Synthetic Growth Defect
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Synthetic Growth Defect
TMA23 YMR269W Nucleolar protein implicated in ribosome biogenesis genetic 1 1 1 Synthetic Growth Defect
TOM5 YPR133W-A Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Synthetic Growth Defect
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Synthetic Growth Defect
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Synthetic Growth Defect
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Synthetic Growth Defect
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Synthetic Growth Defect
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 1 1 1 Synthetic Growth Defect
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Synthetic Growth Defect
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Synthetic Growth Defect
VPS28 YPL065W Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Growth Defect
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Synthetic Growth Defect
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Synthetic Growth Defect
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 1 1 1 Synthetic Growth Defect
YPK1 YKL126W S/T protein kinase genetic 1 1 1 Synthetic Growth Defect
VSB1 YGR125W Vacuolar membrane protein required for uptake and storage of arginine genetic 1 1 1 Synthetic Growth Defect
YDR415C YDR415C Putative aminopeptidase genetic 1 1 1 Synthetic Growth Defect
YLR358C YLR358C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YNL184C YNL184C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YOL029C YOL029C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Synthetic Growth Defect
YGR054W YGR054W Eukaryotic initiation factor eIF2A genetic 1 1 1 Synthetic Growth Defect
YOR302W YOR302W CPA1 uORF genetic 1 1 1 Synthetic Growth Defect
SDH4 YDR178W Membrane anchor subunit of succinate dehydrogenase (SDH) genetic 1 1 1 Negative Genetic
YNK1 YKL067W Nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Negative Genetic
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Phenotypic Suppression
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Phenotypic Suppression
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Phenotypic Suppression
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Synthetic Rescue
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Synthetic Growth Defect
MTG2 YHR168W Putative GTPase genetic 1 1 1 Synthetic Growth Defect
QCR8 YJL166W Subunit 8 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Synthetic Growth Defect
PKH3 YDR466W Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p genetic 1 1 1 Positive Genetic
MRPL49 YJL096W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
RQT4 YKR023W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Positive Genetic
ATR1 YML116W Multidrug efflux pump of the major facilitator superfamily genetic 1 1 1 Synthetic Growth Defect
CPD1 YGR247W Cyclic nucleotide phosphodiesterase genetic 1 1 1 Synthetic Growth Defect
HIT1 YJR055W Protein involved in C/D snoRNP assembly genetic 1 1 1 Synthetic Growth Defect
JJJ3 YJR097W Iron-binding protein physical 1 1 1 Reconstituted Complex
PSR2 YLR019W Putative plasma membrane phosphatase genetic 1 1 1 Negative Genetic
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 1 1 1 Synthetic Growth Defect
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor physical 1 1 1 Reconstituted Complex
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
GPM2 YDL021W Nonfunctional homolog of Gpm1p phosphoglycerate mutase genetic 1 1 1 Synthetic Growth Defect
INO1 YJL153C Inositol-3-phosphate synthase genetic 1 1 1 Synthetic Growth Defect
HER2 YMR293C Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex genetic 1 1 1 Synthetic Growth Defect
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 1 1 1 Synthetic Growth Defect
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Synthetic Growth Defect
DAL2 YIR029W Allantoicase genetic 1 1 1 Synthetic Growth Defect
PEX22 YAL055W Putative peroxisomal membrane protein genetic 1 1 1 Negative Genetic
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Phenotypic Enhancement
RMR1 YGL250W Protein required for meiotic recombination and gene conversion genetic 1 1 1 Synthetic Growth Defect
BSC4 YNL269W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PHA2 YNL316C Prephenate dehydratase genetic 1 1 1 Synthetic Growth Defect
POS5 YPL188W Mitochondrial NADH kinase genetic 1 1 1 Synthetic Growth Defect
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Synthetic Growth Defect
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 1 1 1 Synthetic Growth Defect
NCS6 YGL211W Protein required for uridine thiolation of Gln, Lys, and Glu tRNAs genetic 1 1 1 Negative Genetic
HIS1 YER055C ATP phosphoribosyltransferase genetic 1 1 1 Synthetic Growth Defect
RPS6B YBR181C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
MRPL33 YMR286W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Synthetic Growth Defect
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
LMO1 YLL007C Homolog of mammalian ELMO (Engulfment and celL MOtility) genetic 1 1 1 Synthetic Growth Defect
IRC20 YLR247C E3 ubiquitin ligase and putative helicase genetic 1 1 1 Negative Genetic
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
PIC2 YER053C Mitochondrial copper and phosphate carrier genetic 1 1 1 Synthetic Growth Defect
FLX1 YIL134W Mitochondrial flavin adenine dinucleotide transporter genetic 1 1 1 Synthetic Growth Defect
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
ITR2 YOL103W Myo-inositol transporter genetic 1 1 1 Negative Genetic
OSW2 YLR054C Protein of unknown function reputedly involved in spore wall assembly genetic 1 1 1 Synthetic Growth Defect
OAR1 YKL055C Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase genetic 1 1 1 Negative Genetic
MFA1 YDR461W Mating pheromone a-factor genetic 1 1 1 Synthetic Growth Defect
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Growth Defect
ORT1 YOR130C Ornithine transporter of the mitochondrial inner membrane genetic 1 1 1 Synthetic Growth Defect
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Synthetic Growth Defect
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Positive Genetic
ARG2 YJL071W Acetylglutamate synthase (glutamate N-acetyltransferase) genetic 1 1 1 Synthetic Growth Defect
MME1 YMR166C Transporter of the mitochondrial inner membrane that exports magnesium genetic 1 1 1 Negative Genetic
PPM1 YDR435C Carboxyl methyltransferase genetic 1 1 1 Synthetic Growth Defect
REX3 YLR107W RNA exonuclease genetic 1 1 1 Negative Genetic
MSY1 YPL097W Mitochondrial tyrosyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
MSW1 YDR268W Mitochondrial tryptophanyl-tRNA synthetase genetic 1 1 1 Synthetic Growth Defect
ARG7 YMR062C Mitochondrial ornithine acetyltransferase genetic 1 1 1 Synthetic Growth Defect