Standard name Systematic name Name description Description
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease Evolutionarily-conserved 5'-3' exonuclease; component of cytoplasmic processing (P) bodies involved in mRNA decay; enters the nucleus and positively regulates transcription initiation and elongation; involved in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, telomere maintenance, and turnover of tRNA introns; negative regulator of autophagy; activated by the scavenger decapping enzyme Dcs1p; expression regulated by Ash1p in rich conditions
Visualize the interactome of XRN1
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.981 0.968 0.98

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
XRN1 16 1 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 13 5 10 Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Rescue, Phenotypic Enhancement
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 10 3 8 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 8 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SKI3 YPR189W Ski complex component and TPR protein genetic 8 2 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 6 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality
CDC73 YLR418C Component of the Paf1p complex genetic 5 3 5 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Positive Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 5 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POM34 YLR018C Subunit of the transmembrane ring of the nuclear pore complex (NPC) genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
SAC3 YDR159W mRNA export factor genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPS30A YLR287C-A Protein component of the small (40S) ribosomal subunit genetic 5 2 3 Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 4 4 4 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 4 3 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein physical 4 2 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 4 2 4 Affinity Capture-MS, Affinity Capture-RNA, Affinity Capture-MS, Affinity Capture-RNA
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 4 2 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
YGR054W YGR054W Eukaryotic initiation factor eIF2A physical 4 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KIN1 YDR122W S/T protein kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
BFR1 YOR198C Component of mRNP complexes associated with polyribosomes physical 4 3 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-RNA
RPP2B YDR382W Ribosomal protein P2 beta genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p physical 3 3 3 Proximity Label-MS, Co-crystal Structure, Affinity Capture-MS
EDC3 YEL015W Non-essential conserved protein with a role in mRNA decapping physical 3 3 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-Western
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 2 3 Positive Genetic, Positive Genetic, Negative Genetic
CDC33 YOL139C Translation initiation factor eIF4E physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
NPL3 YDR432W RNA-binding protein physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex physical 3 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
LSM2 YBL026W Lsm (Like Sm) protein physical 3 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
LSM4 YER112W Lsm (Like Sm) protein physical 3 2 3 Two-hybrid, Affinity Capture-MS, Affinity Capture-MS
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-RNA
LSM8 YJR022W Lsm (Like Sm) protein physical 3 2 3 Two-hybrid, Two-hybrid, Affinity Capture-MS
BIM1 YER016W Microtubule plus end-tracking protein genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 3 2 3 Synthetic Lethality, Negative Genetic, Synthetic Lethality
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LSM5 YER146W Lsm (Like Sm) protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
LSM6 YDR378C Lsm (Like Sm) protein physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E physical 3 2 2 Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS
NUC1 YJL208C Major mitochondrial nuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BBC1 YJL020C Protein possibly involved in assembly of actin patches genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARF1 YDL192W ADP-ribosylation factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FYV10 YIL097W Subunit of GID complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RMD1 YDL001W Cytoplasmic protein required for sporulation genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP42 YDR192C FG-nucleoporin component of central core of the nuclear pore complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CQD1 YPL109C UbiB family mitochondrial protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HXK1 YFR053C Hexokinase isoenzyme 1 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VID28 YIL017C GID Complex subunit, serves as adaptor for regulatory subunit Vid24p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ETR1 YBR026C 2-enoyl thioester reductase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL37A YLR185W Ribosomal 60S subunit protein L37A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL35B YDL136W Ribosomal 60S subunit protein L35B genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HPT1 YDR399W Dimeric hypoxanthine-guanine phosphoribosyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
LSC2 YGR244C Beta subunit of succinyl-CoA ligase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MSC1 YML128C Protein of unknown function genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
PMP3 YDR276C Small plasma membrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPS28B YLR264W Protein component of the small (40S) ribosomal subunit genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HES1 YOR237W Protein implicated in the regulation of ergosterol biosynthesis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase genetic 2 2 2 Positive Genetic, Negative Genetic
BRX1 YOL077C Nucleolar protein genetic 2 2 2 Positive Genetic, Negative Genetic
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 2 2 2 Affinity Capture-RNA, Affinity Capture-MS
CEG1 YGL130W Guanylyltransferase involved in mRNA 5' capping genetic 2 2 2 Synthetic Lethality, Synthetic Rescue
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 2 2 2 Negative Genetic, Positive Genetic
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase genetic 2 2 2 Phenotypic Suppression, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
RPO26 YPR187W RNA polymerase subunit ABC23 genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 2 2 2 Negative Genetic, Positive Genetic
EDC3 YEL015W Non-essential conserved protein with a role in mRNA decapping genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 2 2 Dosage Lethality, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 2 2 2 Positive Genetic, Negative Genetic
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Negative Genetic, Synthetic Rescue
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit physical 2 2 2 Co-crystal Structure, Affinity Capture-MS
BIK1 YCL029C Microtubule-associated protein genetic 2 2 2 Synthetic Lethality, Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 2 2 2 Positive Genetic, Phenotypic Suppression
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 2 2 2 Positive Genetic, Synthetic Rescue
TFA2 YKR062W TFIIE small subunit genetic 2 2 2 Negative Genetic, Positive Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Synthetic Lethality, Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 2 2 2 Positive Genetic, Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
BRE1 YDL074C E3 ubiquitin ligase genetic 2 1 2 Negative Genetic, Negative Genetic
YGR054W YGR054W Eukaryotic initiation factor eIF2A genetic 2 1 2 Negative Genetic, Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 2 1 2 Negative Genetic, Negative Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 2 1 2 Positive Genetic, Positive Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 2 1 2 Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 2 1 2 Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 1 2 Negative Genetic, Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 2 1 2 Negative Genetic, Negative Genetic
ECM1 YAL059W Pre-ribosomal factor involved in 60S ribosomal protein subunit export genetic 2 1 2 Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
CMD1 YBR109C Calmodulin genetic 2 1 2 Negative Genetic, Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 2 1 2 Negative Genetic, Negative Genetic
NAM8 YHR086W RNA binding protein, component of the U1 snRNP protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 2 1 2 Positive Genetic, Positive Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Negative Genetic, Negative Genetic
PRP28 YDR243C Pre-mRNA splicing factor genetic 2 1 2 Negative Genetic, Negative Genetic
PRP4 YPR178W Splicing factor genetic 2 1 2 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SAM1 YLR180W S-adenosylmethionine synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SMC3 YJL074C Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 2 1 2 Negative Genetic, Negative Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
PUF3 YLL013C Protein of the mitochondrial outer surface physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
CAF20 YOR276W Phosphoprotein of the mRNA cap-binding complex physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 2 1 2 Positive Genetic, Positive Genetic
LIA1 YJR070C Deoxyhypusine hydroxylase genetic 2 1 2 Negative Genetic, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
UBI4 YLL039C Ubiquitin genetic 2 1 2 Negative Genetic, Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 2 1 2 Negative Genetic, Negative Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
NOP13 YNL175C Nucleolar protein found in preribosomal complexes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MSN5 YDR335W Karyopherin genetic 2 1 2 Negative Genetic, Negative Genetic
RPS26B YER131W Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 2 Negative Genetic, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 2 1 2 Negative Genetic, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 1 2 Positive Genetic, Positive Genetic
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PDR17 YNL264C Phosphatidylinositol transfer protein (PITP) genetic 2 1 2 Negative Genetic, Negative Genetic
MFA2 YNL145W Mating pheromone a-factor genetic 2 1 2 Negative Genetic, Negative Genetic
DOM34 YNL001W Protein that facilitates ribosomal subunit dissociation genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
STB5 YHR178W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 2 1 2 Negative Genetic, Negative Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SRP40 YKR092C Nucleolar serine-rich protein genetic 2 1 2 Positive Genetic, Positive Genetic
UBC8 YEL012W Ubiquitin-conjugating enzyme that regulates gluconeogenesis genetic 2 1 2 Negative Genetic, Negative Genetic
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 2 Negative Genetic, Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 2 1 2 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 2 Negative Genetic, Negative Genetic
PHO5 YBR093C Repressible acid phosphatase genetic 2 1 2 Negative Genetic, Negative Genetic
YMR196W YMR196W Putative protein of unknown function physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
MSS116 YDR194C Mitochondrial transcription elongation factor physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity physical 2 2 1 Affinity Capture-Western, Affinity Capture-MS
CDC33 YOL139C Translation initiation factor eIF4E genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 2 1 1 Negative Genetic, Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 2 1 1 Positive Genetic, Positive Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 2 1 1 Negative Genetic, Negative Genetic
ARP1 YHR129C Actin-related protein of the dynactin complex genetic 2 1 1 Negative Genetic, Negative Genetic
ATG16 YMR159C Conserved protein involved in autophagy genetic 2 1 1 Negative Genetic, Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 1 1 Negative Genetic, Negative Genetic
FCY1 YPR062W Cytosine deaminase genetic 2 1 1 Negative Genetic, Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 2 1 1 Negative Genetic, Negative Genetic
PEX3 YDR329C Peroxisomal membrane protein (PMP) genetic 2 1 1 Negative Genetic, Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 2 1 1 Negative Genetic, Negative Genetic
ELO1 YJL196C Elongase I, medium-chain acyl elongase genetic 2 1 1 Negative Genetic, Negative Genetic
SOV1 YMR066W Mitochondrial protein of unknown function genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 2 1 1 Negative Genetic, Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 2 1 1 Negative Genetic, Negative Genetic
SRF1 YDL133W Regulator of phospholipase D (Spo14p) genetic 2 1 1 Negative Genetic, Negative Genetic
THI72 YOR192C Transporter of thiamine or related compound genetic 2 1 1 Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ASH1 YKL185W Component of the Rpd3L histone deacetylase complex regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
TOR1 YJR066W PIK-related protein kinase and rapamycin target regulation 1 1 1 quantitative reverse transcription polymerase chain reaction evidence
RAD53 YPL153C DNA damage response kinase regulation 1 1 1 protein kinase assay evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Positive Genetic
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Positive Genetic
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Synthetic Growth Defect
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 1 1 1 Synthetic Growth Defect
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 1 1 1 Synthetic Growth Defect
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Positive Genetic
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 1 1 1 Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 physical 1 1 1 Affinity Capture-MS
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Synthetic Growth Defect
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Positive Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
NOP16 YER002W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
NOP4 YPL043W Nucleolar protein physical 1 1 1 Affinity Capture-MS
RPF2 YKR081C Essential protein involved in rRNA maturation and ribosomal assembly physical 1 1 1 Affinity Capture-Western
RPL16A YIL133C Ribosomal 60S subunit protein L16A physical 1 1 1 Affinity Capture-MS
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 1 1 1 Negative Genetic
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins physical 1 1 1 Affinity Capture-MS
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins genetic 1 1 1 Positive Genetic
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
KAP123 YER110C Karyopherin beta genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome physical 1 1 1 Co-purification
POP3 YNL282W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
POP8 YBL018C Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Positive Genetic
RMP1 YLR145W Subunit of RNase MRP genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
SPP382 YLR424W Essential protein that forms a dimer with Ntr2p genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
UTP10 YJL109C Nucleolar protein physical 1 1 1 Affinity Capture-MS
MRT4 YKL009W Protein involved in mRNA turnover and ribosome assembly genetic 1 1 1 Positive Genetic
NOP15 YNL110C Constituent of 66S pre-ribosomal particles physical 1 1 1 Affinity Capture-MS
NOP15 YNL110C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Positive Genetic
CIC1 YHR052W Essential protein that interacts with proteasome components physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Positive Genetic
MES1 YGR264C Methionyl-tRNA synthetase genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform genetic 1 1 1 Negative Genetic
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Positive Genetic
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs genetic 1 1 1 Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Phenotypic Suppression
AIR2 YDL175C RNA-binding subunit of the TRAMP nuclear RNA surveillance complex physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Affinity Capture-MS
YAK1 YJL141C Serine-threonine protein kinase physical 1 1 1 Affinity Capture-MS
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Negative Genetic
YCR087C-A YCR087C-A Putative protein of unknown function genetic 1 1 1 Positive Genetic
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Positive Genetic
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 1 1 1 Synthetic Growth Defect
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 1 1 1 Synthetic Growth Defect
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 1 1 1 Positive Genetic
YAL064W YAL064W Protein of unknown function genetic 1 1 1 Positive Genetic
YPT11 YNL304W Rab GTPase genetic 1 1 1 Positive Genetic
YPI1 YFR003C Regulatory subunit of the type I protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
YDL114W YDL114W Putative short-chain dehydrogenase/reductase genetic 1 1 1 Negative Genetic
YER039C-A YER039C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGR240C-A YGR240C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YOR1 YGR281W Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
YHR054C YHR054C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJL193W YJL193W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJR096W YJR096W Xylose and arabinose reductase genetic 1 1 1 Negative Genetic
YRA2 YKL214C Member of the REF (RNA and export factor binding proteins) family genetic 1 1 1 Negative Genetic
YML037C YML037C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR262W YMR262W Protein of unknown function genetic 1 1 1 Negative Genetic
YNL040W YNL040W Protein of unknown function genetic 1 1 1 Negative Genetic
YNR068C YNR068C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPR015C YPR015C Putative zinc finger transcription factor genetic 1 1 1 Negative Genetic
YCK2 YNL154C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus genetic 1 1 1 Positive Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity genetic 1 1 1 Synthetic Growth Defect
PAB1 YER165W Poly(A) binding protein physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A genetic 1 1 1 Negative Genetic
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein genetic 1 1 1 Positive Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Negative Genetic
CSL4 YNL232W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Synthetic Lethality
RPC40 YPR110C RNA polymerase subunit AC40 physical 1 1 1 Affinity Capture-MS
RPC40 YPR110C RNA polymerase subunit AC40 genetic 1 1 1 Negative Genetic
RRP43 YCR035C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP45 YDR280W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
RPC31 YNL151C RNA polymerase III subunit C31 genetic 1 1 1 Negative Genetic
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPC37 YKR025W RNA polymerase III subunit C37 genetic 1 1 1 Negative Genetic
RPC82 YPR190C RNA polymerase III subunit C82 physical 1 1 1 Affinity Capture-MS
RPC82 YPR190C RNA polymerase III subunit C82 genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Synthetic Lethality
RPL3 YOR063W Ribosomal 60S subunit protein L3 genetic 1 1 1 Phenotypic Suppression
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase genetic 1 1 1 Negative Genetic
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Negative Genetic
MUD1 YBR119W U1 snRNP A protein physical 1 1 1 Affinity Capture-MS
PRP39 YML046W U1 snRNP protein involved in splicing genetic 1 1 1 Negative Genetic
SNU56 YDR240C Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Affinity Capture-MS
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 1 1 1 Affinity Capture-MS
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Positive Genetic
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-Western
GCD1 YOR260W Gamma subunit of the translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Positive Genetic
MPE1 YKL059C Subunit of CPF cleavage and polyadenylation factor and E3 Ub-ligase genetic 1 1 1 Positive Genetic
IMD2 YHR216W Inosine monophosphate dehydrogenase genetic 1 1 1 Negative Genetic
IMD3 YLR432W Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SSD1 YDR293C Translational repressor physical 1 1 1 Affinity Capture-Western
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily physical 1 1 1 Affinity Capture-MS
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Positive Genetic
THS1 YIL078W Threonyl-tRNA synthetase genetic 1 1 1 Negative Genetic
ABD1 YBR236C Methyltransferase genetic 1 1 1 Negative Genetic
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 1 1 1 Negative Genetic
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ASC1 YMR116C G-protein beta subunit and guanine dissociation inhibitor for Gpa2p genetic 1 1 1 Positive Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Positive Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Lethality
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
IPI3 YNL182C Component of the Rix1 complex and pre-replicative complexes (pre-RCs) genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Negative Genetic
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Positive Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) physical 1 1 1 Affinity Capture-MS
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Positive Genetic
CYR1 YJL005W Adenylate cyclase genetic 1 1 1 Negative Genetic
DCP1 YOL149W Subunit of the Dcp1p-Dcp2p decapping enzyme complex physical 1 1 1 Affinity Capture-MS
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs physical 1 1 1 Affinity Capture-MS
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Negative Genetic
GCD7 YLR291C Beta subunit of translation initiation factor eIF2B genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease physical 1 1 1 Affinity Capture-MS
GTR2 YGR163W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-MS
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 1 1 1 Synthetic Growth Defect
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Synthetic Growth Defect
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ECM29 YHL030W Scaffold protein genetic 1 1 1 Negative Genetic
KRR1 YCL059C Nucleolar protein required for rRNA synthesis and ribosomal assembly physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Negative Genetic
LAS17 YOR181W Actin assembly factor genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Rescue
LSM4 YER112W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Negative Genetic
KEL1 YHR158C Protein required for proper cell fusion and cell morphology genetic 1 1 1 Negative Genetic
LUC7 YDL087C Essential protein associated with the U1 snRNP complex physical 1 1 1 Affinity Capture-MS
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 1 1 1 Phenotypic Suppression
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Phenotypic Suppression
MAS1 YLR163C Beta subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
MED2 YDL005C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
MRPL10 YNL284C Mitochondrial ribosomal protein of the large subunit physical 1 1 1 Affinity Capture-MS
MRPL20 YKR085C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
MRH4 YGL064C Mitochondrial ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
MTR10 YOR160W Nuclear import receptor genetic 1 1 1 Synthetic Lethality
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Positive Genetic
NMD3 YHR170W Protein involved in nuclear export of the large ribosomal subunit genetic 1 1 1 Synthetic Lethality
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
NUP116 YMR047C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 1 1 1 Synthetic Growth Defect
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Positive Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
LPD1 YFL018C Dihydrolipoamide dehydrogenase genetic 1 1 1 Negative Genetic
IDH2 YOR136W Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Positive Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
GLE2 YER107C RNA export factor associated with the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
CWC22 YGR278W Spliceosome-associated protein that is required for pre-mRNA splicing genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
PTC3 YBL056W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) physical 1 1 1 Affinity Capture-MS
NRD1 YNL251C RNA-binding subunit of Nrd1 complex physical 1 1 1 Affinity Capture-MS
NRP1 YDL167C Putative RNA binding protein of unknown function physical 1 1 1 Affinity Capture-Western
NRP1 YDL167C Putative RNA binding protein of unknown function genetic 1 1 1 Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Growth Defect
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Positive Genetic
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NOC4 YPR144C Nucleolar protein physical 1 1 1 Affinity Capture-MS
RAD16 YBR114W Nucleotide excision repair (NER) protein genetic 1 1 1 Negative Genetic
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Positive Genetic
RAI1 YGL246C Nuclear decapping endonuclease genetic 1 1 1 Dosage Rescue
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Positive Genetic
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Phenotypic Suppression
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Positive Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Synthetic Growth Defect
PPH21 YDL134C Catalytic subunit of protein phosphatase 2A, PP2A genetic 1 1 1 Negative Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Positive Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
PIL1 YGR086C Eisosome core component physical 1 1 1 Affinity Capture-MS
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
KTR3 YBR205W Putative alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Phenotypic Enhancement
RIE1 YGR250C RNA binding protein and negative regulator of START physical 1 1 1 Affinity Capture-Western
RIE1 YGR250C RNA binding protein and negative regulator of START genetic 1 1 1 Positive Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 1 1 1 Positive Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
PRP42 YDR235W U1 snRNP protein involved in splicing genetic 1 1 1 Negative Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Synthetic Lethality
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Synthetic Rescue
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Negative Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase physical 1 1 1 Affinity Capture-MS
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Positive Genetic
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 genetic 1 1 1 Negative Genetic
SEN54 YPL083C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
TFA1 YKL028W TFIIE large subunit genetic 1 1 1 Positive Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway physical 1 1 1 Affinity Capture-MS
SEC3 YER008C Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
FDH1 YOR388C NAD(+)-dependent formate dehydrogenase genetic 1 1 1 Negative Genetic
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Affinity Capture-MS
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 1 1 1 Positive Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-MS
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 1 1 1 Phenotypic Suppression
LTV1 YKL143W Subunit of the EGO/GSE complex genetic 1 1 1 Positive Genetic
ROK1 YGL171W RNA-dependent ATPase genetic 1 1 1 Dosage Rescue
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Negative Genetic
LSP1 YPL004C Eisosome core component physical 1 1 1 Affinity Capture-MS
FET4 YMR319C Low-affinity Fe(II) transporter of the plasma membrane genetic 1 1 1 Synthetic Rescue
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Positive Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Positive Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Positive Genetic
DCS1 YLR270W Non-essential hydrolase involved in mRNA decapping physical 1 1 1 Reconstituted Complex
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Positive Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
CPR6 YLR216C Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Synthetic Growth Defect
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Dosage Growth Defect
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Affinity Capture-MS
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 1 1 1 Negative Genetic
PKH2 YOL100W Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
MDM30 YLR368W F-box component of an SCF ubiquitin protein ligase complex genetic 1 1 1 Negative Genetic
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-RNA
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Positive Genetic
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 1 1 1 Phenotypic Enhancement
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Negative Genetic
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
FUM1 YPL262W Fumarase genetic 1 1 1 Negative Genetic
ELA1 YNL230C Elongin A genetic 1 1 1 Negative Genetic
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Affinity Capture-MS
ERG1 YGR175C Squalene epoxidase physical 1 1 1 Affinity Capture-MS
IMD4 YML056C Inosine monophosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Negative Genetic
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Negative Genetic
APE1 YKL103C Vacuolar aminopeptidase yscI genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Positive Genetic
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 1 1 1 Positive Genetic
GYP5 YPL249C GTPase-activating protein (GAP) for yeast Rab family members genetic 1 1 1 Positive Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
MAK11 YKL021C Protein involved in an early step of 60S ribosomal subunit biogenesis genetic 1 1 1 Phenotypic Suppression
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Positive Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis physical 1 1 1 Affinity Capture-MS
KRI1 YNL308C Essential nucleolar protein required for 40S ribosome biogenesis genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 physical 1 1 1 Affinity Capture-MS
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Positive Genetic
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex genetic 1 1 1 Negative Genetic
HHT1 YBR010W Histone H3 physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 1 1 1 Phenotypic Enhancement
TMA108 YIL137C Ribosome-associated, nascent chain binding factor physical 1 1 1 Affinity Capture-MS
DPB11 YJL090C DNA replication initiation protein genetic 1 1 1 Positive Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Positive Genetic
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 1 1 1 Positive Genetic
ATG4 YNL223W Conserved cysteine protease required for autophagy genetic 1 1 1 Negative Genetic
SKI2 YLR398C Ski complex component and putative RNA helicase physical 1 1 1 Affinity Capture-MS
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase physical 1 1 1 Affinity Capture-MS
AIR1 YIL079C Zinc knuckle protein physical 1 1 1 Affinity Capture-MS
AIR1 YIL079C Zinc knuckle protein genetic 1 1 1 Positive Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
FKH2 YNL068C Forkhead family transcription factor genetic 1 1 1 Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 1 1 1 Negative Genetic
LSM8 YJR022W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
RAD53 YPL153C DNA damage response kinase physical 1 1 1 Biochemical Activity
ASR1 YPR093C Ubiquitin ligase that modifies and regulates RNA Pol II genetic 1 1 1 Negative Genetic
CPR3 YML078W Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 1 1 1 Positive Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
FUS3 YBL016W Mitogen-activated serine/threonine protein kinase involved in mating genetic 1 1 1 Positive Genetic
GBP2 YCL011C Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-Western
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Negative Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 1 1 1 Negative Genetic
IGO1 YNL157W Protein required for initiation of G0 program genetic 1 1 1 Phenotypic Suppression
QCR7 YDR529C Subunit 7 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
GDH2 YDL215C NAD(+)-dependent glutamate dehydrogenase genetic 1 1 1 Negative Genetic
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Positive Genetic
AFG3 YER017C Mitochondrial inner membrane m-AAA protease component genetic 1 1 1 Positive Genetic
KKQ8 YKL168C Putative serine/threonine protein kinase with unknown cellular role genetic 1 1 1 Positive Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Positive Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Negative Genetic
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
SKA1 YKL023W SKI complex-associated protein physical 1 1 1 Affinity Capture-MS
SKA1 YKL023W SKI complex-associated protein genetic 1 1 1 Negative Genetic
PEX29 YDR479C ER-resident protein involved in peroxisomal biogenesis genetic 1 1 1 Phenotypic Enhancement
EBS1 YDR206W Protein involved in translation inhibition and nonsense-mediated decay genetic 1 1 1 Phenotypic Enhancement
ARG81 YML099C Zinc finger transcription factor involved in arginine-responsive genes genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Phenotypic Enhancement
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Positive Genetic
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 1 1 1 Synthetic Growth Defect
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Positive Genetic
RPS26B YER131W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Co-crystal Structure
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Affinity Capture-MS
QCR6 YFR033C Subunit 6 of the ubiquinol cytochrome-c reductase complex genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein physical 1 1 1 Affinity Capture-MS
ISY1 YJR050W Member of the NineTeen Complex (NTC) genetic 1 1 1 Positive Genetic
TOP1 YOL006C Topoisomerase I genetic 1 1 1 Phenotypic Suppression
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Affinity Capture-MS
SEC10 YLR166C Essential 100kDa subunit of the exocyst complex genetic 1 1 1 Negative Genetic
CTL1 YMR180C RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm genetic 1 1 1 Negative Genetic
PPA2 YMR267W Mitochondrial inorganic pyrophosphatase genetic 1 1 1 Positive Genetic
SYO1 YDL063C Transport adaptor or symportin genetic 1 1 1 Negative Genetic
KTI12 YKL110C Protein that plays a role in modification of tRNA wobble nucleosides genetic 1 1 1 Positive Genetic
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
PIR5 YJL160C Putative protein of unknown function genetic 1 1 1 Negative Genetic
CUE2 YKL090W Ubiquitin-binding endonuclease involved in mRNA decay genetic 1 1 1 Phenotypic Suppression
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 genetic 1 1 1 Negative Genetic
ELP6 YMR312W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Positive Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Synthetic Lethality
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
ELP3 YPL086C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Negative Genetic
RPS24B YIL069C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Positive Genetic
BRE5 YNR051C Ubiquitin protease cofactor physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes physical 1 1 1 Affinity Capture-MS
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Enhancement
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
PRP2 YNR011C RNA-dependent DExD/H-box ATPase genetic 1 1 1 Phenotypic Enhancement
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family physical 1 1 1 Affinity Capture-MS
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS8B YER102W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Co-crystal Structure
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit genetic 1 1 1 Negative Genetic
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS22A YJL190C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein physical 1 1 1 Affinity Capture-MS
MIF2 YKL089W Centromeric CDEIII region binding protein genetic 1 1 1 Synthetic Growth Defect
RIF1 YBR275C Protein involved in control of DNA replication genetic 1 1 1 Synthetic Rescue
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Positive Genetic
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Negative Genetic
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 1 1 1 Synthetic Growth Defect
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Negative Genetic
MAD1 YGL086W Coiled-coil protein involved in spindle-assembly checkpoint genetic 1 1 1 Synthetic Lethality
MCM3 YEL032W Protein involved in DNA replication genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Negative Genetic
NRG1 YDR043C Transcriptional repressor genetic 1 1 1 Phenotypic Suppression
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
REC102 YLR329W Protein involved in early stages of meiotic recombination genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel physical 1 1 1 Affinity Capture-MS
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Positive Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
MPS2 YGL075C Essential membrane protein localized at nuclear envelope and SPBs genetic 1 1 1 Synthetic Lethality
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Positive Genetic
TIF4632 YGL049C Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-Western
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Positive Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein physical 1 1 1 Affinity Capture-Western
RSM22 YKL155C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Positive Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Positive Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
PPR1 YLR014C Zinc finger transcription factor genetic 1 1 1 Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Positive Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Negative Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing physical 1 1 1 Affinity Capture-MS
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 1 1 1 Positive Genetic
FCP1 YMR277W Carboxy-terminal domain (CTD) phosphatase genetic 1 1 1 Negative Genetic
RBL2 YOR265W Protein involved in microtubule morphogenesis genetic 1 1 1 Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
BPT1 YLL015W ABC type transmembrane transporter of MRP/CFTR family physical 1 1 1 PCA
MET32 YDR253C Zinc-finger DNA-binding transcription factor genetic 1 1 1 Negative Genetic
MID2 YLR332W O-glycosylated plasma membrane protein genetic 1 1 1 Negative Genetic
OTU1 YFL044C Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p genetic 1 1 1 Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 1 1 1 Positive Genetic
HRI1 YLR301W Protein of unknown function that interacts with Sec72p and Hrr25p genetic 1 1 1 Negative Genetic
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Positive Genetic
OSH3 YHR073W Member of an oxysterol-binding protein family genetic 1 1 1 Synthetic Growth Defect
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways physical 1 1 1 Two-hybrid
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Negative Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 1 1 1 Synthetic Growth Defect
PBP1 YGR178C Component of glucose deprivation induced stress granules physical 1 1 1 Affinity Capture-Western
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Negative Genetic
PFY1 YOR122C Profilin genetic 1 1 1 Negative Genetic
SSO2 YMR183C Plasma membrane t-SNARE genetic 1 1 1 Negative Genetic
RPL25 YOL127W Ribosomal 60S subunit protein L25 physical 1 1 1 Affinity Capture-MS
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
OAF1 YAL051W Oleate-activated transcription factor genetic 1 1 1 Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Positive Genetic
CCH1 YGR217W Voltage-gated high-affinity calcium channel genetic 1 1 1 Positive Genetic
KAR1 YNL188W Protein involved in karyogamy and spindle pole body duplication genetic 1 1 1 Phenotypic Enhancement
CQD1 YPL109C UbiB family mitochondrial protein physical 1 1 1 Affinity Capture-MS
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-MS
HHT2 YNL031C Histone H3 genetic 1 1 1 Phenotypic Enhancement
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
AUR1 YKL004W Phosphatidylinositol:ceramide phosphoinositol transferase genetic 1 1 1 Synthetic Rescue
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-MS
MSL5 YLR116W Component of commitment complex physical 1 1 1 Affinity Capture-MS
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Negative Genetic
PXA1 YPL147W Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa2p physical 1 1 1 PCA
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) physical 1 1 1 Affinity Capture-RNA
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
PRS4 YBL068W 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP genetic 1 1 1 Negative Genetic
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Positive Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Positive Genetic
TUB1 YML085C Alpha-tubulin genetic 1 1 1 Synthetic Growth Defect
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Positive Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 1 1 1 Positive Genetic
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
TFB4 YPR056W Subunit of TFIIH complex genetic 1 1 1 Negative Genetic
RPS14A YCR031C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
RPL21A YBR191W Ribosomal 60S subunit protein L21A genetic 1 1 1 Negative Genetic
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
PRP24 YMR268C Splicing factor that reanneals snRNPs during spliceosome recycling genetic 1 1 1 Negative Genetic
PDS5 YMR076C Cohesion maintenance factor physical 1 1 1 Affinity Capture-MS
PDS5 YMR076C Cohesion maintenance factor genetic 1 1 1 Positive Genetic
PXA2 YKL188C Subunit of heterodimeric peroxisomal ABC transport complex, with Pxa1p physical 1 1 1 PCA
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 1 1 1 Negative Genetic
HBS1 YKR084C GTPase with similarity to translation release factors genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Negative Genetic
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Negative Genetic
CPS1 YJL172W Vacuolar carboxypeptidase S genetic 1 1 1 Negative Genetic
COQ9 YLR201C Protein required for ubiquinone biosynthesis and respiratory growth physical 1 1 1 Affinity Capture-MS
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Growth Defect
DDR2 YOL052C-A Multi-stress response protein genetic 1 1 1 Positive Genetic
AVT6 YER119C Vacuolar aspartate and glutamate exporter genetic 1 1 1 Positive Genetic
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Negative Genetic
TFB3 YDR460W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
TRM8 YDL201W Catalytic subunit of a tRNA methyltransferase complex genetic 1 1 1 Phenotypic Suppression
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Positive Genetic
DIC1 YLR348C Mitochondrial dicarboxylate carrier genetic 1 1 1 Negative Genetic
MRH1 YDR033W Protein that localizes primarily to the plasma membrane genetic 1 1 1 Negative Genetic
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
RPL43B YJR094W-A Ribosomal 60S subunit protein L43B genetic 1 1 1 Negative Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate physical 1 1 1 Affinity Capture-Western
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Phenotypic Suppression
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
BUL2 YML111W Alpha-arrestin, component of the Rsp5p E3-ubiquitin ligase complex physical 1 1 1 Affinity Capture-MS
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Positive Genetic
GID11 YLR149C Substrate receptor of the glucose-induced degradation-deficient (GID) genetic 1 1 1 Negative Genetic
AIM22 YJL046W Lipoate-protein ligase genetic 1 1 1 Negative Genetic
HTD2 YHR067W Mitochondrial 3-hydroxyacyl-thioester dehydratase genetic 1 1 1 Negative Genetic
ISD11 YER048W-A Cysteine desulfurase (Nfs1p) activator genetic 1 1 1 Positive Genetic
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 1 1 1 Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions physical 1 1 1 Affinity Capture-MS
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 1 1 1 Negative Genetic
SAS10 YDL153C Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
IRC8 YJL051W Bud tip localized protein of unknown function genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Positive Genetic
SPC1 YJR010C-A Subunit of the signal peptidase complex (SPC) genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Positive Genetic
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Negative Genetic
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
MEF1 YLR069C Mitochondrial elongation factor involved in translational elongation genetic 1 1 1 Negative Genetic
CAJ1 YER048C Nuclear type II J heat shock protein of the E. coli dnaJ family genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Positive Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Negative Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 1 1 1 Synthetic Rescue
CSH1 YBR161W Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Synthetic Rescue
FRD1 YEL047C Soluble fumarate reductase genetic 1 1 1 Negative Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 1 1 1 Negative Genetic
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-MS
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Positive Genetic
TGL5 YOR081C Bifunctional triacylglycerol lipase and LPA acyltransferase genetic 1 1 1 Negative Genetic
TMA46 YOR091W Protein of unknown function that associates with translating ribosomes physical 1 1 1 Affinity Capture-MS
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
GYP7 YDL234C GTPase-activating protein for yeast Rab family members genetic 1 1 1 Negative Genetic
RPL12A YEL054C Ribosomal 60S subunit protein L12A genetic 1 1 1 Negative Genetic
PTH2 YBL057C One of two mitochondrially-localized peptidyl-tRNA hydrolases genetic 1 1 1 Positive Genetic
BSC2 YDR275W Protein of unknown function involved in multidrug resistance genetic 1 1 1 Negative Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Negative Genetic
PHB2 YGR231C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Positive Genetic
RPS22B YLR367W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Co-crystal Structure
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Negative Genetic
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Negative Genetic
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14B YJL191W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Co-crystal Structure
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 1 1 1 Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 1 1 1 Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 1 1 1 Phenotypic Suppression
RPL33B YOR234C Ribosomal 60S subunit protein L33B genetic 1 1 1 Negative Genetic
ISR1 YPR106W Predicted protein kinase physical 1 1 1 Affinity Capture-MS
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 1 1 1 Negative Genetic
IDI1 YPL117C Isopentenyl diphosphate:dimethylallyl diphosphate isomerase genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Negative Genetic
RPL36A YMR194W Ribosomal 60S subunit protein L36A genetic 1 1 1 Negative Genetic
RPS29B YDL061C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
RPS12 YOR369C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
APJ1 YNL077W Hsp40 chaperone with a role in SUMO-mediated protein degradation physical 1 1 1 Affinity Capture-MS
INP54 YOL065C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 1 1 1 Positive Genetic
PTK2 YJR059W Serine/threonine protein kinase genetic 1 1 1 Positive Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Positive Genetic
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
SUB1 YMR039C Transcriptional regulator genetic 1 1 1 Negative Genetic
NMD4 YLR363C Protein that may be involved in nonsense-mediated mRNA decay genetic 1 1 1 Positive Genetic
SET5 YHR207C Methyltransferase involved in methylation of histone H4 Lys5, -8, -12 genetic 1 1 1 Negative Genetic
VHS3 YOR054C Negative regulatory subunit of protein phosphatase 1 Ppz1p genetic 1 1 1 Negative Genetic
SCD6 YPR129W Repressor of translation initiation physical 1 1 1 Affinity Capture-Western
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Positive Genetic
PKH3 YDR466W Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p genetic 1 1 1 Negative Genetic
UFD1 YGR048W Substrate-recruiting cofactor of the Cdc48p-Npl4p-Ufd1p segregase genetic 1 1 1 Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Positive Genetic
RPS27A YKL156W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
DNF2 YDR093W Aminophospholipid translocase (flippase) genetic 1 1 1 Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 1 1 1 Negative Genetic
SMA1 YPL027W Protein of unknown function involved in prospore membrane assembly genetic 1 1 1 Negative Genetic
JJJ3 YJR097W Iron-binding protein genetic 1 1 1 Negative Genetic
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Negative Genetic
AST2 YER101C Lipid raft associated protein genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Positive Genetic
ENA5 YDR038C Protein with similarity to P-type ATPase sodium pumps genetic 1 1 1 Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 1 1 1 Synthetic Growth Defect
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Positive Genetic
UGA2 YBR006W Succinate semialdehyde dehydrogenase genetic 1 1 1 Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA physical 1 1 1 Affinity Capture-MS
ASP3-4 YLR160C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Negative Genetic
VOA1 YGR106C ER protein that functions in assembly of the V0 sector of V-ATPase genetic 1 1 1 Synthetic Growth Defect
FAA3 YIL009W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Positive Genetic
GPI13 YLL031C ER membrane localized phosphoryltransferase genetic 1 1 1 Negative Genetic
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Positive Genetic
BOL1 YAL044W-A Mitochondrial matrix protein involved in Fe-S cluster biogenesis genetic 1 1 1 Negative Genetic
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
PHS1 YJL097W Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane genetic 1 1 1 Negative Genetic
GPI14 YJR013W Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Synthetic Lethality
AVL9 YLR114C Conserved protein involved in exocytic transport from the Golgi genetic 1 1 1 Positive Genetic
CCW14 YLR390W-A Covalently linked cell wall glycoprotein genetic 1 1 1 Negative Genetic
SAM50 YNL026W Component of the Sorting and Assembly Machinery (SAM) complex physical 1 1 1 Affinity Capture-MS
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Positive Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Positive Genetic
VMA9 YCL005W-A Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex genetic 1 1 1 Negative Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex genetic 1 1 1 Negative Genetic
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 1 1 1 Negative Genetic
CCC2 YDR270W Cu(+2)-transporting P-type ATPase genetic 1 1 1 Negative Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
IGO2 YHR132W-A Protein required for initiation of G0 program genetic 1 1 1 Phenotypic Suppression
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Negative Genetic
LIP2 YLR239C Lipoyl ligase genetic 1 1 1 Negative Genetic
DIT2 YDR402C N-formyltyrosine oxidase genetic 1 1 1 Negative Genetic
CAB2 YIL083C Phosphopantothenoylcysteine synthetase (PPCS) genetic 1 1 1 Negative Genetic
ERG8 YMR220W Phosphomevalonate kinase genetic 1 1 1 Negative Genetic
CQD2 YLR253W Mitochondrial protein involved in lipid homeostasis genetic 1 1 1 Positive Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
NMA111 YNL123W Serine protease and general molecular chaperone genetic 1 1 1 Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 1 1 1 Positive Genetic
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p physical 1 1 1 Affinity Capture-RNA
PMP2 YEL017C-A Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p) genetic 1 1 1 Negative Genetic
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Negative Genetic
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Negative Genetic
PTK1 YKL198C Putative serine/threonine protein kinase physical 1 1 1 Affinity Capture-MS
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Negative Genetic
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
MFM1 YPL060W Mitochondrial inner membrane magnesium transporter genetic 1 1 1 Negative Genetic
SMY2 YBR172C GYF domain protein physical 1 1 1 Affinity Capture-MS
RPS30B YOR182C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
TIS11 YLR136C mRNA-binding protein expressed during iron starvation physical 1 1 1 PCA
SFA1 YDL168W Bifunctional alcohol dehydrogenase and formaldehyde dehydrogenase genetic 1 1 1 Negative Genetic
RPL42B YHR141C Ribosomal 60S subunit protein L42B genetic 1 1 1 Phenotypic Suppression
PGA3 YML125C Putative cytochrome b5 reductase, localized to the plasma membrane genetic 1 1 1 Negative Genetic
RPS28A YOR167C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Co-crystal Structure
SND2 YLR065C Protein involved in SRP-independent targeting of substrates to the ER genetic 1 1 1 Negative Genetic
MET22 YOL064C Bisphosphate-3'-nucleotidase genetic 1 1 1 Negative Genetic
OCT1 YKL134C Mitochondrial intermediate peptidase genetic 1 1 1 Negative Genetic
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Positive Genetic
SRP72 YPL210C Core component of the signal recognition particle (SRP) genetic 1 1 1 Negative Genetic
LST4 YKL176C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Positive Genetic
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Affinity Capture-MS
IDP2 YLR174W Cytosolic NADP-specific isocitrate dehydrogenase genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Negative Genetic
MRX20 YFR045W Putative mitochondrial transport protein genetic 1 1 1 Negative Genetic
MME1 YMR166C Transporter of the mitochondrial inner membrane that exports magnesium genetic 1 1 1 Negative Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 1 1 1 Phenotypic Enhancement
SMP1 YBR182C MADS-box transcription factor involved in osmotic stress response genetic 1 1 1 Negative Genetic
MRX4 YPL168W Protein that associates with mitochondrial ribosome genetic 1 1 1 Negative Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Negative Genetic
SRC1 YML034W Inner nuclear membrane protein genetic 1 1 1 Negative Genetic
HXT13 YEL069C Putative transmembrane polyol transporter genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
RIT1 YMR283C Initiator methionine 2'-O-ribosyl phosphate transferase genetic 1 1 1 Negative Genetic
ADF1 YCL058W-A Transcriptional repressor encoded by the FYV5 antisense strand genetic 1 1 1 Negative Genetic
STL1 YDR536W Glycerol proton symporter of the plasma membrane physical 1 1 1 Affinity Capture-RNA
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 1 1 1 Negative Genetic
TOH1 YJL171C GPI-anchored cell wall protein of unknown function genetic 1 1 1 Positive Genetic
GRX8 YLR364W Glutaredoxin that employs a dithiol mechanism of catalysis genetic 1 1 1 Negative Genetic
VPS70 YJR126C Protein of unknown function involved in vacuolar protein sorting genetic 1 1 1 Negative Genetic
PZF1 YPR186C Transcription factor IIIA (TFIIIA) genetic 1 1 1 Negative Genetic
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Positive Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Negative Genetic
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth genetic 1 1 1 Negative Genetic
TAD3 YLR316C Subunit of tRNA-specific adenosine-34 deaminase genetic 1 1 1 Positive Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
WAR1 YML076C Homodimeric Zn2Cys6 zinc finger transcription factor genetic 1 1 1 Negative Genetic
TRM12 YML005W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Negative Genetic
THI7 YLR237W Plasma membrane transporter responsible for the uptake of thiamine genetic 1 1 1 Negative Genetic
PAU15 YIR041W Protein of unknown function genetic 1 1 1 Negative Genetic
TTI2 YJR136C Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Negative Genetic
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Negative Genetic
TSR4 YOL022C Cytoplasmic assembly chaperone for ribosomal protein Rps2p genetic 1 1 1 Negative Genetic