Standard name Systematic name Name description Description
RAD51 YER095W Strand exchange protein Strand exchange protein; forms helical filament with DNA that searches for homology; involved in recombinational repair of DNA DSBs during vegetative growth and meiosis; phosphorylation by Cdc28p in G2/M phase promotes DNA binding, strand invasion, and primer extension; L1 and L2 motifs of DNA binding site I have critical roles in ensuring DNA fidelity during meiotic recombination; RAD51 and RAD4 pathways confer resistance to benzo[a]pyrene dihydrodiol; homolog of Dmc1p and bacterial RecA
Visualize the interactome of RAD51
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
M 154

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.815 0.976 0.996
Mito 0.306 0.063 NaN

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 6960

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAD51 8 2 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD52 YML032C Protein involved in homologous recombination physical 43 5 32 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Co-localization, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 35 7 32 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Positive Genetic, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 31 5 30 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Rescue, Positive Genetic, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Positive Genetic, Positive Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 23 5 22 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Positive Genetic, Positive Genetic, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Positive Genetic, Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange physical 23 3 19 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 19 7 16 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Positive Genetic, Dosage Lethality, Dosage Rescue
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 17 3 12 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Two-hybrid
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 16 3 16 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
POL32 YJR043C Third subunit of DNA polymerase delta genetic 16 4 13 Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 16 3 13 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 14 4 12 Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein physical 13 5 13 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, PCA, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Two-hybrid, Co-fractionation, Two-hybrid, Two-hybrid
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 13 5 11 Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
TSA1 YML028W Thioredoxin peroxidase genetic 11 3 8 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 11 3 8 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 10 5 9 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Positive Genetic, Dosage Rescue
RAD57 YDR004W Protein that stimulates strand exchange genetic 10 4 9 Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Phenotypic Suppression, Positive Genetic, Positive Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 10 3 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 9 4 9 Dosage Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic, Phenotypic Suppression, Dosage Rescue, Synthetic Rescue, Positive Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 9 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Dosage Growth Defect, Negative Genetic, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange physical 8 2 8 Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 8 4 7 Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Negative Genetic
REV1 YOR346W Deoxycytidyl transferase genetic 8 4 7 Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 8 3 7 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect
HED1 YDR014W-A Meiosis-specific protein physical 8 2 5 Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Two-hybrid
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 7 5 7 Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Enhancement, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 7 4 7 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 7 3 7 Synthetic Growth Defect, Phenotypic Enhancement, Positive Genetic, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 7 3 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Positive Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 7 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 6 5 6 Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Positive Genetic
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 6 3 6 Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Synthetic Lethality, Synthetic Rescue, Synthetic Rescue
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 6 3 6 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 6 2 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression, Negative Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 6 4 5 Synthetic Lethality, Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Suppression
RDH54 YBR073W DNA-dependent ATPase genetic 6 4 4 Synthetic Rescue, Dosage Growth Defect, Dosage Rescue, Synthetic Rescue, Phenotypic Suppression, Dosage Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 6 1 4 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 5 4 5 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic, Synthetic Growth Defect
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Phenotypic Enhancement
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 5 3 5 Affinity Capture-MS, Affinity Capture-MS, Co-localization, Reconstituted Complex, Affinity Capture-MS
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 5 3 5 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 5 2 5 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
ASF1 YJL115W Nucleosome assembly factor genetic 5 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 5 3 4 Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Positive Genetic
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 5 3 4 Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Phenotypic Suppression, Phenotypic Enhancement
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 5 3 4 Dosage Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 5 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 5 4 3 Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 5 3 3 Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement
RNH203 YLR154C Ribonuclease H2 subunit genetic 5 4 1 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Phenotypic Suppression
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 4 4 4 Dosage Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 4 3 4 Negative Genetic, Negative Genetic, Synthetic Lethality, Phenotypic Suppression
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) physical 4 2 4 Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Phenotypic Enhancement
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic, Phenotypic Enhancement
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 4 3 3 Negative Genetic, Negative Genetic, Phenotypic Suppression, Synthetic Lethality
CTF4 YPR135W Chromatin-associated protein genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
BRE1 YDL074C E3 ubiquitin ligase genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 4 2 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 3 3 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 3 3 3 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 3 3 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect
SWI6 YLR182W Transcription cofactor genetic 3 3 3 Synthetic Lethality, Positive Genetic, Dosage Rescue
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 3 3 3 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression
TOP1 YOL006C Topoisomerase I genetic 3 3 3 Synthetic Growth Defect, Negative Genetic, Synthetic Rescue
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
RAD24 YER173W Checkpoint protein genetic 3 3 3 Dosage Rescue, Synthetic Lethality, Phenotypic Suppression
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 3 3 3 Synthetic Growth Defect, Synthetic Rescue, Positive Genetic
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 3 3 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression
FKH2 YNL068C Forkhead family transcription factor regulation 3 2 3 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 3 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
LSM7 YNL147W Lsm (Like Sm) protein genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RDH54 YBR073W DNA-dependent ATPase physical 3 2 3 Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
RAD53 YPL153C DNA damage response kinase genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 3 2 3 Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair physical 3 2 3 Reconstituted Complex, Reconstituted Complex, Two-hybrid
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 3 2 3 Synthetic Growth Defect, Positive Genetic, Positive Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 3 2 3 Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 3 3 2 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Enhancement
HSP82 YPL240C Hsp90 chaperone genetic 3 3 2 Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 3 2 2 Two-hybrid, Affinity Capture-Western, Two-hybrid
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
GET1 YGL020C Subunit of the GET complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RRI1 YDL216C Catalytic subunit of the COP9 signalosome (CSN) complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
YJR124C YJR124C Putative protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ARE2 YNR019W Acyl-CoA:sterol acyltransferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APE2 YKL157W Aminopeptidase yscII genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CHS6 YJL099W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
KIP3 YGL216W Kinesin-related antiparallel sliding motor protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 3 3 1 Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
LSM1 YJL124C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 2 2 2 Dosage Growth Defect, Dosage Lethality
PRP4 YPR178W Splicing factor genetic 2 2 2 Negative Genetic, Synthetic Lethality
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange physical 2 2 2 Two-hybrid, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 2 2 2 Two-hybrid, Reconstituted Complex
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
SML1 YML058W Ribonucleotide reductase inhibitor genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
YEF3 YLR249W Translation elongation factor 3 genetic 2 2 2 Positive Genetic, Synthetic Lethality
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 2 2 2 Negative Genetic, Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
YEN1 YER041W Holliday junction resolvase genetic 2 2 2 Phenotypic Suppression, Synthetic Growth Defect
RME1 YGR044C Zinc finger protein involved in control of meiosis genetic 2 2 2 Synthetic Rescue, Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 2 2 2 Synthetic Lethality, Phenotypic Enhancement
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 2 2 2 Positive Genetic, Phenotypic Enhancement
CIK1 YMR198W Kinesin-associated protein genetic 2 2 2 Negative Genetic, Synthetic Lethality
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
RAD17 YOR368W Checkpoint protein genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
PRI1 YIR008C Subunit of DNA primase genetic 2 2 2 Negative Genetic, Phenotypic Enhancement
PSY3 YLR376C Component of Shu complex (aka PCSS complex) physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 2 2 2 Synthetic Lethality, Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 2 1 2 Negative Genetic, Negative Genetic
ARO1 YDR127W Pentafunctional arom protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 1 2 Negative Genetic, Negative Genetic
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
HSL1 YKL101W Nim1p-related protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ILV1 YER086W Threonine deaminase, catalyzes first step in isoleucine biosynthesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPB2 YOR151C RNA polymerase II second largest subunit B150 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
YHB1 YGR234W Nitric oxide oxidoreductase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TOP3 YLR234W DNA Topoisomerase III genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
ZIP1 YDR285W Transverse filament protein of the synaptonemal complex genetic 2 1 2 Phenotypic Enhancement, Phenotypic Enhancement
THP1 YOL072W Nuclear pore-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
SIZ1 YDR409W SUMO E3 ligase genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
SLM4 YBR077C Subunit of the EGO/GSE complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 2 1 2 Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 1 2 Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 2 1 2 Negative Genetic, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 1 2 Positive Genetic, Positive Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
CCC1 YLR220W Vacuolar Fe2+/Mn2+ transporter genetic 2 1 2 Negative Genetic, Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 2 1 2 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
NPL6 YMR091C Component of the RSC chromatin remodeling complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 2 1 Synthetic Growth Defect, Synthetic Lethality
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 2 2 1 Synthetic Growth Defect, Synthetic Rescue
ESC2 YDR363W Sumo-like domain protein genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
EPL1 YFL024C Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
UBP14 YBR058C Ubiquitin-specific protease genetic 2 1 1 Negative Genetic, Negative Genetic
YUH1 YJR099W Ubiquitin C-terminal hydrolase genetic 2 1 1 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 2 1 1 Negative Genetic, Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 1 Negative Genetic, Negative Genetic
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
KAR3 YPR141C Minus-end-directed microtubule motor genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
AVT5 YBL089W Putative transporter genetic 2 1 1 Negative Genetic, Negative Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit regulation 1 1 1 protein kinase assay evidence
SUA7 YPR086W Transcription factor TFIIB regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED6 YHR058C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 DNA to cDNA expression microarray evidence
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Phenotypic Suppression
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Positive Genetic
HSP60 YLR259C Tetradecameric mitochondrial chaperonin physical 1 1 1 Affinity Capture-MS
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B genetic 1 1 1 Synthetic Lethality
KAP123 YER110C Karyopherin beta physical 1 1 1 Affinity Capture-MS
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Synthetic Rescue
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
LTO1 YNL260C Substrate-specific adaptor protein involved in apo-Rli1p maturation genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Synthetic Lethality
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein genetic 1 1 1 Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Growth Defect
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAM7 YMR080C ATP-dependent RNA helicase of the SFI superfamily genetic 1 1 1 Synthetic Rescue
APC2 YLR127C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 Two-hybrid
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 1 1 1 Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Phenotypic Enhancement
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Phenotypic Enhancement
NSA2 YER126C Protein constituent of 66S pre-ribosomal particles genetic 1 1 1 Synthetic Lethality
COX6 YHR051W Subunit VI of cytochrome c oxidase (Complex IV) genetic 1 1 1 Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 1 1 1 Synthetic Lethality
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 1 1 1 Synthetic Rescue
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
GEA2 YEL022W Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) genetic 1 1 1 Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Synthetic Lethality
MAS1 YLR163C Beta subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Synthetic Lethality
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED6 YHR058C Subunit of the RNA polymerase II mediator complex physical 1 1 1 Affinity Capture-MS
MED6 YHR058C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis physical 1 1 1 Affinity Capture-MS
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Suppression
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
HRR25 YPL204W Conserved casein kinase, monopolin subunit physical 1 1 1 Two-hybrid
MRPL8 YJL063C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Synthetic Growth Defect
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Phenotypic Suppression
MSH3 YCR092C Mismatch repair protein genetic 1 1 1 Phenotypic Suppression
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control physical 1 1 1 Affinity Capture-MS
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Phenotypic Suppression
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
IES5 YER092W Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
OST1 YJL002C Alpha subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Synthetic Lethality
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Phenotypic Suppression
PCF11 YDR228C mRNA 3' end processing factor genetic 1 1 1 Synthetic Lethality
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Phenotypic Enhancement
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Negative Genetic
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Phenotypic Suppression
PRP31 YGR091W Splicing factor genetic 1 1 1 Synthetic Lethality
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 1 1 1 Affinity Capture-MS
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Synthetic Lethality
VRP1 YLR337C Verprolin, proline-rich actin-associated protein physical 1 1 1 Affinity Capture-MS
SAP1 YER047C Putative ATPase of the AAA family physical 1 1 1 Two-hybrid
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 1 1 1 Two-hybrid
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Synthetic Lethality
TRI1 YMR233W Non-essential sumoylated protein of unknown function physical 1 1 1 Two-hybrid
RAD59 YDL059C Protein involved DNA double-strand break repair physical 1 1 1 Affinity Capture-Western
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 1 1 1 Affinity Capture-MS
SAW1 YAL027W 5'- and 3'-flap DNA binding protein physical 1 1 1 Reconstituted Complex
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Reconstituted Complex
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) physical 1 1 1 Reconstituted Complex
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 1 1 1 Phenotypic Enhancement
RED1 YLR263W Protein component of the synaptonemal complex axial elements genetic 1 1 1 Synthetic Rescue
SIR3 YLR442C Silencing protein genetic 1 1 1 Synthetic Rescue
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
TAH1 YCR060W Component of conserved R2TP complex (Rvb1-Rvb2-Tah1-Pih1) genetic 1 1 1 Positive Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
YCK3 YER123W Palmitoylated vacuolar membrane-localized casein kinase I isoform genetic 1 1 1 Negative Genetic
TSA2 YDR453C Stress inducible cytoplasmic thioredoxin peroxidase genetic 1 1 1 Synthetic Rescue
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Phenotypic Enhancement
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Growth Defect
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Phenotypic Suppression
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Synthetic Lethality
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Phenotypic Suppression
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Positive Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Positive Genetic
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Positive Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Positive Genetic
UNG1 YML021C Uracil-DNA glycosylase genetic 1 1 1 Phenotypic Suppression
RNH1 YMR234W Ribonuclease H1 genetic 1 1 1 Synthetic Growth Defect
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Synthetic Growth Defect
TFC3 YAL001C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Synthetic Lethality
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Synthetic Lethality
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Synthetic Lethality
RSC6 YCR052W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 1 1 1 Synthetic Lethality
SRB7 YDR308C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Lethality
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Synthetic Lethality
YCG1 YDR325W Subunit of the condensin complex genetic 1 1 1 Synthetic Lethality
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 1 1 1 Synthetic Lethality
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Synthetic Lethality
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Synthetic Lethality
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Synthetic Lethality
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Lethality
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Synthetic Lethality
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Synthetic Lethality
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication genetic 1 1 1 Synthetic Lethality
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 1 1 1 Synthetic Lethality
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Synthetic Lethality
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Synthetic Lethality
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Synthetic Lethality
SEC59 YMR013C Dolichol kinase genetic 1 1 1 Synthetic Lethality
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Synthetic Lethality
TIF11 YMR260C Translation initiation factor eIF1A genetic 1 1 1 Synthetic Lethality
TOP2 YNL088W Topoisomerase II genetic 1 1 1 Synthetic Lethality
SUI1 YNL244C Translation initiation factor eIF1 genetic 1 1 1 Synthetic Lethality
RRS1 YOR294W Essential protein that binds ribosomal protein L11 genetic 1 1 1 Synthetic Lethality
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 1 1 1 Synthetic Lethality
TIM50 YPL063W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Phenotypic Suppression
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Phenotypic Suppression
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Phenotypic Suppression
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Negative Genetic
TRR1 YDR353W Cytoplasmic thioredoxin reductase genetic 1 1 1 Synthetic Rescue
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
REB1 YBR049C RNA polymerase I enhancer binding protein genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
YRA1 YDR381W Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
UTP8 YGR128C Nucleolar protein required for export of tRNAs from the nucleus genetic 1 1 1 Negative Genetic
SMD2 YLR275W Core Sm protein Sm D2 genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SMX3 YPR182W Core Sm protein Sm F genetic 1 1 1 Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 1 1 1 Negative Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Negative Genetic
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
TRP4 YDR354W Anthranilate phosphoribosyl transferase genetic 1 1 1 Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Negative Genetic
RPS27B YHR021C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
YFH7 YFR007W Putative kinase with similarity to the PRK/URK/PANK kinase subfamily genetic 1 1 1 Negative Genetic
XKS1 YGR194C Xylulokinase genetic 1 1 1 Negative Genetic
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
ROF1 YHR177W Putative transcription factor containing a WOPR domain genetic 1 1 1 Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Negative Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
YLL056C YLL056C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
YML020W YML020W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YML054C-A YML054C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
TCB3 YML072C Cortical ER protein involved in ER-plasma membrane tethering genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
YVC1 YOR087W Vacuolar cation channel genetic 1 1 1 Negative Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Negative Genetic
SPO24 YPR036W-A Small (67 amino acids) protein involved in sporulation genetic 1 1 1 Negative Genetic
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
SIW14 YNL032W Inositol phosphatase involved in inositol pyrophosphate metabolism genetic 1 1 1 Positive Genetic
SPE2 YOL052C S-adenosylmethionine decarboxylase genetic 1 1 1 Positive Genetic
SPE1 YKL184W Ornithine decarboxylase genetic 1 1 1 Positive Genetic
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Phenotypic Suppression
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Synthetic Growth Defect
RGI1 YER067W Protein involved in energy metabolism under respiratory conditions genetic 1 1 1 Phenotypic Enhancement
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Phenotypic Enhancement
SPT20 YOL148C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Phenotypic Enhancement
VMA22 YHR060W Protein that is required for vacuolar H+-ATPase (V-ATPase) function genetic 1 1 1 Phenotypic Enhancement
YLR358C YLR358C Protein of unknown function genetic 1 1 1 Phenotypic Enhancement
SHU2 YDR078C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Positive Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 1 1 1 Negative Genetic
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Rescue
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase genetic 1 1 1 Positive Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
MTR3 YGR158C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Synthetic Lethality
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Phenotypic Enhancement
DIA4 YHR011W Probable mitochondrial seryl-tRNA synthetase genetic 1 1 1 Synthetic Lethality
CAR2 YLR438W L-ornithine transaminase (OTAse) genetic 1 1 1 Positive Genetic
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor genetic 1 1 1 Positive Genetic
FIN1 YDR130C Spindle pole body-related intermediate filament protein genetic 1 1 1 Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 1 1 1 Negative Genetic
CSR2 YPR030W Nuclear ubiquitin protein ligase binding protein genetic 1 1 1 Negative Genetic
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Synthetic Lethality
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
AAC3 YBR085W Mitochondrial inner membrane ADP/ATP translocator genetic 1 1 1 Positive Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Negative Genetic
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
KOG1 YHR186C Subunit of TORC1 genetic 1 1 1 Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
ENV7 YPL236C Vacuolar membrane protein kinase genetic 1 1 1 Negative Genetic
CLN1 YMR199W G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Positive Genetic
PGM2 YMR105C Phosphoglucomutase genetic 1 1 1 Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CAT5 YOR125C Protein required for ubiquinone (Coenzyme Q) biosynthesis genetic 1 1 1 Positive Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 1 1 1 Reconstituted Complex
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Lethality
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Synthetic Lethality
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 genetic 1 1 1 Synthetic Lethality
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Phenotypic Enhancement
ISU1 YPL135W Conserved protein of the mitochondrial matrix genetic 1 1 1 Negative Genetic
MEK1 YOR351C Meiosis-specific serine/threonine protein kinase genetic 1 1 1 Synthetic Rescue
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 1 1 1 Synthetic Growth Defect
LIF1 YGL090W Component of the DNA ligase IV complex genetic 1 1 1 Synthetic Growth Defect
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-Western
CPR3 YML078W Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Positive Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Synthetic Growth Defect
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Phenotypic Enhancement
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 1 1 1 Positive Genetic
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 1 1 1 Phenotypic Enhancement
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Positive Genetic
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Lethality
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Phenotypic Suppression
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Synthetic Growth Defect
MRX21 YPR011C Mitochondrial transporter physical 1 1 1 Two-hybrid
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Positive Genetic
CHA4 YLR098C DNA binding transcriptional activator genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CLB1 YGR108W B-type cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
NFI1 YOR156C SUMO E3 ligase genetic 1 1 1 Phenotypic Suppression
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Lethality
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Positive Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 1 1 1 Phenotypic Enhancement
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Phenotypic Enhancement
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Positive Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
HOP2 YGL033W Meiosis-specific protein that localizes to chromosomes genetic 1 1 1 Dosage Rescue
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Growth Defect
MEX67 YPL169C Poly(A)RNA binding protein involved in nuclear mRNA export genetic 1 1 1 Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Phenotypic Enhancement
CST9 YLR394W SUMO E3 ligase physical 1 1 1 Two-hybrid
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
HMT1 YBR034C Nuclear SAM-dependent mono- and asymmetric methyltransferase genetic 1 1 1 Positive Genetic
MET28 YIR017C bZIP transcriptional activator in the Cbf1p-Met4p-Met28p complex genetic 1 1 1 Positive Genetic
HRI1 YLR301W Protein of unknown function that interacts with Sec72p and Hrr25p genetic 1 1 1 Negative Genetic
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-Western
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Phenotypic Enhancement
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Synthetic Lethality
ERV14 YGL054C COPII-coated vesicle protein genetic 1 1 1 Phenotypic Suppression
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Growth Defect
FLO8 YER109C Transcription factor genetic 1 1 1 Negative Genetic
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 1 1 1 Affinity Capture-MS
GTA1 YEL043W Protein of unknown function genetic 1 1 1 Negative Genetic
HMG1 YML075C HMG-CoA reductase physical 1 1 1 Affinity Capture-MS
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Growth Defect
MEI5 YPL121C Meiosis-specific protein involved in meiotic recombination physical 1 1 1 Reconstituted Complex
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
MSS11 YMR164C Transcription factor genetic 1 1 1 Positive Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Positive Genetic
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Synthetic Lethality
PDC2 YDR081C Transcription factor for thiamine-regulated genes genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Positive Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Synthetic Lethality
PSP2 YML017W Asn rich cytoplasmic protein that contains RGG motifs genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
FAS1 YKL182W Beta subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
PML39 YML107C Protein required for nuclear retention of unspliced pre-mRNAs genetic 1 1 1 Negative Genetic
OSM1 YJR051W Fumarate reductase, catalyzes the reduction of fumarate to succinate genetic 1 1 1 Negative Genetic
IRC19 YLL033W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 1 1 1 Affinity Capture-MS
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Positive Genetic
NMT1 YLR195C N-myristoyl transferase genetic 1 1 1 Synthetic Lethality
PUF2 YPR042C PUF family mRNA-binding protein physical 1 1 1 Affinity Capture-RNA
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Phenotypic Suppression
MTM1 YGR257C Mitochondrial protein of the mitochondrial carrier family genetic 1 1 1 Negative Genetic
PKH3 YDR466W Protein kinase with similarity to mammalian PDK1 and yeast Pkh1p/Phk2p genetic 1 1 1 Positive Genetic
HED1 YDR014W-A Meiosis-specific protein genetic 1 1 1 Phenotypic Suppression
MRPL49 YJL096W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Synthetic Growth Defect
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Negative Genetic
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
PCH2 YBR186W Hexameric ring ATPase that remodels chromosome axis protein Hop1p genetic 1 1 1 Phenotypic Suppression
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Phenotypic Enhancement
BUD16 YEL029C Putative pyridoxal kinase genetic 1 1 1 Synthetic Growth Defect
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
GPI1 YGR216C Membrane protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Growth Defect
AIM33 YML087C Protein of unknown function, highly conserved across species genetic 1 1 1 Positive Genetic
POF1 YCL047C Nicotinamide mononucleotide-specific adenylyltransferase (NMNAT) genetic 1 1 1 Negative Genetic
PHO3 YBR092C Constitutively expressed acid phosphatase similar to Pho5p genetic 1 1 1 Positive Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Positive Genetic
HNT3 YOR258W DNA 5' AMP hydrolase involved in DNA repair genetic 1 1 1 Synthetic Rescue
PGA1 YNL158W Essential component of GPI-mannosyltransferase II genetic 1 1 1 Negative Genetic