Standard name Systematic name Name description Description
SRS2 YJL092W DNA helicase and DNA-dependent ATPase DNA helicase and DNA-dependent ATPase; role in DNA repair and checkpoint recovery, in the proper timing of commitment to meiotic recombination and the Meiosis I to II transition; blocks trinucleotide repeat expansion; affects genome stability; disassembles Rad51p nucleoprotein filaments during meiotic recombination; stimulates Mus81p-Mms4p endonuclease activity independent of catalytic activity; ATPase and ssDNA translocating motor activities inhibited by Dmc1p; functional homolog of human RTEL1
Visualize the interactome of SRS2
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
S 66

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.052 0.081 0.100
Nucleus 0.905 0.667 0.584
Vac/Vac Memb 0.076 0.111 NaN
Mito NaN 0.303 0.550

GFP localization & abundance

GFP localization GFP abundance
no data no data

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
SRS2 6 0 0 0 0

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 44 6 38 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Lethality, Dosage Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 35 7 32 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Positive Genetic, Phenotypic Suppression
RAD18 YCR066W E3 ubiquitin ligase genetic 25 3 25 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Rescue
RAD52 YML032C Protein involved in homologous recombination genetic 24 7 22 Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Dosage Lethality, Dosage Lethality, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Negative Genetic, Synthetic Rescue
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 21 6 19 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Dosage Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange genetic 20 7 16 Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Dosage Lethality, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic, Negative Genetic, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 20 6 14 Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 19 4 17 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 19 5 14 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 18 5 15 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Synthetic Rescue, Positive Genetic, Negative Genetic, Synthetic Rescue
RAD51 YER095W Strand exchange protein physical 17 3 12 Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Two-hybrid, Reconstituted Complex, Two-hybrid
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 16 5 12 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality
CSM3 YMR048W Replication fork associated factor genetic 16 4 12 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 15 4 13 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 14 4 10 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 13 4 11 Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement
POL32 YJR043C Third subunit of DNA polymerase delta genetic 13 4 11 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 13 4 10 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 13 4 9 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 12 3 11 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
ESC2 YDR363W Sumo-like domain protein genetic 12 4 10 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 12 4 9 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
RAD57 YDR004W Protein that stimulates strand exchange genetic 11 4 10 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Lethality, Positive Genetic, Phenotypic Suppression, Positive Genetic, Synthetic Rescue
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 11 4 8 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Negative Genetic, Negative Genetic
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 10 4 9 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Phenotypic Suppression, Negative Genetic, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 10 3 9 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) physical 10 4 8 Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
CHL1 YPL008W Probable DNA helicase genetic 10 2 8 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 10 5 7 Two-hybrid, Two-hybrid, Affinity Capture-MS, Two-hybrid, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Two-hybrid, Protein-peptide, Reconstituted Complex
TOP3 YLR234W DNA Topoisomerase III genetic 9 4 8 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Negative Genetic, Synthetic Lethality
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 9 4 7 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Synthetic Growth Defect
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 9 4 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Synthetic Lethality
RTT109 YLL002W Histone acetyltransferase genetic 9 4 7 Negative Genetic, Negative Genetic, Negative Genetic, Dosage Lethality, Dosage Lethality, Dosage Rescue, Negative Genetic, Negative Genetic, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 9 4 6 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 8 3 8 Negative Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 8 4 7 Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 8 4 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic, Negative Genetic
RAD59 YDL059C Protein involved DNA double-strand break repair genetic 7 5 7 Phenotypic Enhancement, Phenotypic Suppression, Dosage Lethality, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 7 4 7 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic, Synthetic Growth Defect
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 7 4 6 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression, Phenotypic Suppression, Negative Genetic, Synthetic Lethality
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 7 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 7 3 6 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Dosage Lethality, Dosage Lethality, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 6 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
TSA1 YML028W Thioredoxin peroxidase genetic 6 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RAD61 YDR014W Subunit of a complex that inhibits sister chromatid cohesion genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 5 4 5 Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 5 3 4 Negative Genetic, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality, Synthetic Growth Defect
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 5 3 4 Positive Genetic, Positive Genetic, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
NFI1 YOR156C SUMO E3 ligase genetic 5 4 3 Dosage Lethality, Dosage Lethality, Synthetic Growth Defect, Dosage Rescue, Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 5 3 3 Negative Genetic, Negative Genetic, Dosage Lethality, Dosage Lethality, Positive Genetic
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 5 3 3 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 5 3 2 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 4 3 4 Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 4 2 4 Synthetic Rescue, Positive Genetic, Synthetic Rescue, Positive Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 4 3 3 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
RAD52 YML032C Protein involved in homologous recombination physical 4 2 3 Two-hybrid, Reconstituted Complex, Two-hybrid, Two-hybrid
MHF1 YOL086W-A Component of the heterotetrameric MHF histone-fold complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RNH202 YDR279W Ribonuclease H2 subunit genetic 4 4 2 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 4 3 2 Two-hybrid, Biochemical Activity, Reconstituted Complex, Two-hybrid
DDC1 YPL194W DNA damage checkpoint protein genetic 3 3 3 Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 3 3 3 Dosage Lethality, Synthetic Growth Defect, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
ORC3 YLL004W Subunit of the origin recognition complex (ORC) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HSP26 YBR072W Small heat shock protein (sHSP) with chaperone activity genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 3 3 2 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
NFI1 YOR156C SUMO E3 ligase physical 3 3 2 Two-hybrid, Biochemical Activity, Reconstituted Complex
SIZ1 YDR409W SUMO E3 ligase physical 3 3 2 Two-hybrid, Biochemical Activity, Reconstituted Complex
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 3 3 2 Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
TOP1 YOL006C Topoisomerase I genetic 3 3 2 Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 3 2 2 Synthetic Lethality, Dosage Lethality, Dosage Lethality
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 3 2 2 Negative Genetic, Dosage Lethality, Dosage Lethality
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 3 2 2 Synthetic Growth Defect, Dosage Lethality, Dosage Lethality
RDH54 YBR073W DNA-dependent ATPase genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Rescue
MHF2 YDL160C-A Component of the heterotetrameric MHF histone-fold complex genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 3 2 1 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
ESC2 YDR363W Sumo-like domain protein physical 3 2 1 Reconstituted Complex, Reconstituted Complex, Two-hybrid
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 2 2 Dosage Lethality, Negative Genetic
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Enhancement
NSE3 YDR288W Component of the SMC5-SMC6 complex genetic 2 2 2 Dosage Rescue, Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 2 2 2 Synthetic Growth Defect, Dosage Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
MCM2 YBL023C Protein involved in DNA replication genetic 2 2 2 Synthetic Rescue, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex physical 2 2 2 Two-hybrid, Reconstituted Complex
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 2 2 Dosage Lethality, Synthetic Growth Defect
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 2 2 2 Synthetic Rescue, Positive Genetic
RAD17 YOR368W Checkpoint protein genetic 2 2 2 Synthetic Rescue, Phenotypic Enhancement
CNM67 YNL225C Component of the spindle pole body outer plaque genetic 2 2 2 Synthetic Growth Defect, Dosage Rescue
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 2 2 2 Dosage Lethality, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Growth Defect, Dosage Lethality
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 2 2 2 Synthetic Growth Defect, Dosage Lethality
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 2 2 Synthetic Lethality, Dosage Lethality
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 1 2 Negative Genetic, Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 2 1 2 Negative Genetic, Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 2 1 2 Negative Genetic, Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 2 1 2 Negative Genetic, Negative Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 2 1 2 Negative Genetic, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
RAD55 YDR076W Protein that stimulates strand exchange physical 2 1 2 Reconstituted Complex, Reconstituted Complex
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase physical 2 1 2 Two-hybrid, Two-hybrid
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes physical 2 1 2 Two-hybrid, Two-hybrid
SCC2 YDR180W Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 2 Negative Genetic, Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
POL32 YJR043C Third subunit of DNA polymerase delta physical 2 1 2 Two-hybrid, Two-hybrid
PDS5 YMR076C Cohesion maintenance factor genetic 2 1 2 Negative Genetic, Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
STN1 YDR082W Telomere end-binding and capping protein genetic 2 1 2 Negative Genetic, Negative Genetic
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 2 1 2 Negative Genetic, Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SCC4 YER147C Subunit of cohesin loading factor (Scc2p-Scc4p) genetic 2 1 2 Negative Genetic, Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Negative Genetic, Negative Genetic
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 2 1 2 Negative Genetic, Negative Genetic
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 2 2 1 Affinity Capture-MS, Affinity Capture-Western
RAD59 YDL059C Protein involved DNA double-strand break repair physical 2 2 1 Two-hybrid, Reconstituted Complex
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 2 2 1 Reconstituted Complex, Two-hybrid
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) physical 2 2 1 Affinity Capture-Western, Two-hybrid
YEN1 YER041W Holliday junction resolvase genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) physical 2 2 1 Affinity Capture-Western, Two-hybrid
MTE1 YGR042W Protein of unknown function genetic 2 2 1 Synthetic Growth Defect, Phenotypic Suppression
CDC40 YDR364C Pre-mRNA splicing factor genetic 2 1 1 Dosage Lethality, Dosage Lethality
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 2 1 1 Dosage Lethality, Dosage Lethality
CTF3 YLR381W Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p genetic 2 1 1 Dosage Lethality, Dosage Lethality
MCM22 YJR135C Outer kinetochore protein and component of the Ctf3 subcomplex genetic 2 1 1 Dosage Lethality, Dosage Lethality
NKP1 YDR383C Central kinetochore protein and subunit of the Ctf19 complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RRP8 YDR083W Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 2 1 1 Dosage Lethality, Dosage Lethality
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit genetic 2 1 1 Dosage Lethality, Dosage Lethality
HHF1 YBR009C Histone H4 genetic 2 1 1 Dosage Lethality, Dosage Lethality
IML3 YBR107C Outer kinetochore protein and component of the Ctf19 complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 2 1 1 Dosage Lethality, Dosage Lethality
DOA4 YDR069C Ubiquitin hydrolase genetic 2 1 1 Dosage Lethality, Dosage Lethality
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 1 Dosage Lethality, Dosage Lethality
MSH4 YFL003C Protein involved in meiotic recombination genetic 2 1 1 Dosage Lethality, Dosage Lethality
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 2 1 1 Dosage Lethality, Dosage Lethality
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 2 1 1 Dosage Lethality, Dosage Lethality
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
SKI2 YLR398C Ski complex component and putative RNA helicase genetic 2 1 1 Dosage Lethality, Dosage Lethality
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 2 1 1 Dosage Lethality, Dosage Lethality
MCM16 YPR046W Component of the Ctf19 complex and the COMA subcomplex genetic 2 1 1 Dosage Lethality, Dosage Lethality
MSN5 YDR335W Karyopherin genetic 2 1 1 Dosage Lethality, Dosage Lethality
IES6 YEL044W Component of the INO80 chromatin remodeling complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
SNF6 YHL025W Subunit of the SWI/SNF chromatin remodeling complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 2 1 1 Dosage Lethality, Dosage Lethality
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 2 1 1 Dosage Lethality, Dosage Lethality
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
CNN1 YFR046C Kinetochore protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 2 1 1 Affinity Capture-MS, Affinity Capture-MS
TMS1 YDR105C Vacuolar membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 2 1 1 Negative Genetic, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 2 1 1 Dosage Lethality, Dosage Lethality
VMA6 YLR447C Subunit d of the V0 integral membrane domain of V-ATPase genetic 2 1 1 Dosage Lethality, Dosage Lethality
STP22 YCL008C Component of the ESCRT-I complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
VPS25 YJR102C Component of the ESCRT-II complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 2 1 1 Dosage Lethality, Dosage Lethality
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 2 1 1 Dosage Lethality, Dosage Lethality
TDA1 YMR291W Protein kinase of unknown cellular role genetic 2 1 1 Dosage Lethality, Dosage Lethality
TDA2 YER071C Subunit of a complex that associates with actin filaments genetic 2 1 1 Dosage Lethality, Dosage Lethality
TDA4 YJR116W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 2 1 1 Dosage Lethality, Dosage Lethality
TDA6 YPR157W Putative protein of unknown function genetic 2 1 1 Dosage Lethality, Dosage Lethality
TDA11 YHR159W Putative protein of unknown function genetic 2 1 1 Dosage Lethality, Dosage Lethality
TNA1 YGR260W High affinity nicotinic acid plasma membrane permease genetic 2 1 1 Dosage Lethality, Dosage Lethality
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 2 1 1 Dosage Lethality, Dosage Lethality
CGI121 YML036W Component of the EKC/KEOPS complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 2 1 1 Dosage Lethality, Dosage Lethality
NTG2 YOL043C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 2 1 1 Dosage Lethality, Dosage Lethality
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 2 1 1 Dosage Lethality, Dosage Lethality
SRC1 YML034W Inner nuclear membrane protein genetic 2 1 1 Dosage Lethality, Dosage Lethality
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 1 1 Positive Genetic, Positive Genetic
FKH1 YIL131C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
FKH2 YNL068C Forkhead family transcription factor regulation 1 1 1 ChEC-Seq experiments
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UME6 YDR207C Rpd3L histone deacetylase complex subunit regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SWI6 YLR182W Transcription cofactor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 1 1 1 Dosage Rescue
CHL4 YDR254W Outer kinetochore protein required for chromosome stability genetic 1 1 1 Dosage Lethality
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 1 1 1 Dosage Lethality
NSE1 YLR007W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
IKI3 YLR384C Subunit of Elongator complex physical 1 1 1 Two-hybrid
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
HAS1 YMR290C ATP-dependent RNA helicase genetic 1 1 1 Dosage Rescue
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Two-hybrid
GON7 YJL184W Component of the EKC/KEOPS protein complex genetic 1 1 1 Synthetic Lethality
IMH1 YLR309C Protein involved in vesicular transport genetic 1 1 1 Dosage Lethality
SAP1 YER047C Putative ATPase of the AAA family physical 1 1 1 Two-hybrid
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function physical 1 1 1 Two-hybrid
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 Affinity Capture-MS
DBP3 YGL078C RNA-Dependent ATPase, member of DExD/H-box family genetic 1 1 1 Dosage Lethality
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences genetic 1 1 1 Dosage Lethality
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs physical 1 1 1 Affinity Capture-MS
LSM1 YJL124C Lsm (Like Sm) protein genetic 1 1 1 Dosage Lethality
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Dosage Rescue
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP6 YOR001W Nuclear exosome exonuclease component genetic 1 1 1 Dosage Lethality
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Dosage Lethality
RPB5 YBR154C RNA polymerase subunit ABC27 genetic 1 1 1 Negative Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 1 1 1 Dosage Rescue
RRB1 YMR131C Specific assembly chaperone for ribosomal protein Rpl3p physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex physical 1 1 1 Two-hybrid
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Lethality
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing genetic 1 1 1 Dosage Lethality
NAP1 YKR048C Histone chaperone and assembly chaperone for Rps6a/b physical 1 1 1 Two-hybrid
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 1 1 1 Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-MS
AAH1 YNL141W Adenine deaminase (adenine aminohydrolase) genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Dosage Lethality
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Growth Defect
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Positive Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 1 1 1 Phenotypic Suppression
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
ATP11 YNL315C Molecular chaperone genetic 1 1 1 Negative Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Synthetic Lethality
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Dosage Lethality
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 1 1 1 Dosage Lethality
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
CYS4 YGR155W Cystathionine beta-synthase genetic 1 1 1 Dosage Lethality
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 1 1 1 Synthetic Growth Defect
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Dosage Lethality
ERP2 YAL007C Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Dosage Lethality
HHF2 YNL030W Histone H4 genetic 1 1 1 Dosage Lethality
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Phenotypic Suppression
IOC3 YFR013W Subunit of the Isw1a complex physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ECM29 YHL030W Scaffold protein physical 1 1 1 Two-hybrid
KIN3 YAR018C Nonessential serine/threonine protein kinase physical 1 1 1 Two-hybrid
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Positive Genetic
CRM1 YGR218W Nuclear export factor, exportin genetic 1 1 1 Dosage Rescue
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Dosage Lethality
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 1 1 1 Dosage Lethality
HRR25 YPL204W Conserved casein kinase, monopolin subunit genetic 1 1 1 Negative Genetic
MRPL28 YDR462W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
MRPL7 YDR237W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
MRPS5 YBR251W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions physical 1 1 1 Two-hybrid
MTR10 YOR160W Nuclear import receptor physical 1 1 1 Two-hybrid
KAP114 YGL241W Karyopherin, responsible for nuclear import of specific proteins physical 1 1 1 Two-hybrid
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
MRPL15 YLR312W-A Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Growth Defect
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Synthetic Rescue
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 1 1 1 Two-hybrid
MRPL38 YKL170W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Dosage Rescue
NAB3 YPL190C RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p) genetic 1 1 1 Positive Genetic
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Dosage Lethality
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Synthetic Growth Defect
GPT2 YKR067W Glycerol-3-phosphate/dihydroxyacetone phosphate sn-1 acyltransferase physical 1 1 1 Affinity Capture-MS
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) physical 1 1 1 Affinity Capture-MS
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 1 1 1 Dosage Rescue
AMS1 YGL156W Vacuolar alpha mannosidase physical 1 1 1 Affinity Capture-MS
MLH2 YLR035C Protein involved in mismatch repair and meiotic recombination physical 1 1 1 Two-hybrid
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Synthetic Lethality
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Positive Genetic
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) physical 1 1 1 Two-hybrid
RPP2B YDR382W Ribosomal protein P2 beta genetic 1 1 1 Dosage Lethality
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 1 1 1 Dosage Lethality
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 1 1 1 Dosage Lethality
MSL1 YIR009W U2B component of U2 snRNP physical 1 1 1 Two-hybrid
MSL1 YIR009W U2B component of U2 snRNP genetic 1 1 1 Dosage Lethality
SNF12 YNR023W 73 kDa subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Dosage Lethality
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Positive Genetic
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase physical 1 1 1 Two-hybrid
MRPL23 YOR150W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
CRN1 YLR429W Coronin physical 1 1 1 Affinity Capture-MS
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Dosage Lethality
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Lethality
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 1 1 1 Synthetic Growth Defect
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA physical 1 1 1 Affinity Capture-RNA
HEK2 YBL032W RNA binding protein involved in asymmetric localization of ASH1 mRNA genetic 1 1 1 Dosage Lethality
LTV1 YKL143W Subunit of the EGO/GSE complex genetic 1 1 1 Dosage Lethality
SKI3 YPR189W Ski complex component and TPR protein genetic 1 1 1 Dosage Lethality
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 1 1 1 Positive Genetic
ACO1 YLR304C Aconitase genetic 1 1 1 Dosage Lethality
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone physical 1 1 1 Two-hybrid
PYC2 YBR218C Pyruvate carboxylase isoform physical 1 1 1 Affinity Capture-MS
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) genetic 1 1 1 Synthetic Lethality
ISA2 YPR067W Protein required for maturation of mitochondrial [4Fe-4S] proteins genetic 1 1 1 Dosage Lethality
NMD5 YJR132W Karyopherin physical 1 1 1 Two-hybrid
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange physical 1 1 1 Reconstituted Complex
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Affinity Capture-MS
SAC6 YDR129C Fimbrin, actin-bundling protein genetic 1 1 1 Dosage Lethality
HTB1 YDR224C Histone H2B genetic 1 1 1 Dosage Rescue
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Dosage Lethality
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Dosage Lethality
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Synthetic Growth Defect
KOG1 YHR186C Subunit of TORC1 physical 1 1 1 Affinity Capture-MS
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
SEC53 YFL045C Phosphomannomutase physical 1 1 1 Affinity Capture-MS
QCR2 YPR191W Subunit 2 of ubiquinol cytochrome-c reductase (Complex III) genetic 1 1 1 Dosage Lethality
FAR1 YJL157C CDK inhibitor and nuclear anchor physical 1 1 1 Two-hybrid
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Dosage Lethality
MTC5 YDR128W Subunit of SEACAT, a subcomplex of the SEA complex physical 1 1 1 Two-hybrid
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription physical 1 1 1 Two-hybrid
PDS1 YDR113C Securin genetic 1 1 1 Negative Genetic
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Dosage Lethality
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p genetic 1 1 1 Dosage Rescue
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 1 1 1 Synthetic Growth Defect
BUD32 YGR262C Protein kinase genetic 1 1 1 Dosage Lethality
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Positive Genetic
RAD24 YER173W Checkpoint protein genetic 1 1 1 Synthetic Rescue
KSP1 YHR082C Serine/threonine protein kinase physical 1 1 1 Two-hybrid
FAA1 YOR317W Long chain fatty acyl-CoA synthetase genetic 1 1 1 Dosage Lethality
MAG1 YER142C 3-methyl-adenine DNA glycosylase genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) physical 1 1 1 Two-hybrid
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Dosage Rescue
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 1 1 1 Negative Genetic
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Dosage Rescue
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion physical 1 1 1 Two-hybrid
FZO1 YBR179C Mitofusin, protein involved in mitochondrial outer membrane fusion genetic 1 1 1 Dosage Lethality
HMG2 YLR450W HMG-CoA reductase genetic 1 1 1 Dosage Lethality
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Dosage Lethality
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 1 1 1 Synthetic Growth Defect
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) physical 1 1 1 Two-hybrid
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Phenotypic Suppression
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Synthetic Rescue
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
CIN5 YOR028C Basic leucine zipper (bZIP) transcription factor of the yAP-1 family genetic 1 1 1 Dosage Lethality
PEX15 YOL044W Tail-anchored type II integral peroxisomal membrane protein genetic 1 1 1 Dosage Lethality
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Positive Genetic
JJJ1 YNL227C Co-chaperone that stimulates the ATPase activity of Ssa1p genetic 1 1 1 Dosage Lethality
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Lethality
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Growth Defect
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Dosage Lethality
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Dosage Lethality
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 1 1 1 Synthetic Growth Defect
MCM10 YIL150C Essential chromatin-associated protein genetic 1 1 1 Synthetic Lethality
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
SHU2 YDR078C Component of Shu complex (aka PCSS complex) physical 1 1 1 Two-hybrid
SHU2 YDR078C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Negative Genetic
IME4 YGL192W mRNA N6-adenosine methyltransferase physical 1 1 1 Two-hybrid
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
IKS1 YJL057C Protein kinase of unknown cellular role physical 1 1 1 Two-hybrid
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 1 1 1 Positive Genetic
PBY1 YBR094W Putative tubulin tyrosine ligase associated with P-bodies genetic 1 1 1 Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation physical 1 1 1 Two-hybrid
SAE2 YGL175C Endonuclease required for telomere elongation genetic 1 1 1 Phenotypic Enhancement
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Dosage Rescue
CAK1 YFL029C Cyclin-dependent kinase-activating kinase genetic 1 1 1 Positive Genetic
ACF4 YJR083C Protein of unknown function genetic 1 1 1 Negative Genetic
SPC19 YDR201W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Dosage Lethality
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p physical 1 1 1 Affinity Capture-MS
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
SMC5 YOL034W Subunit of the SMC5-SMC6 complex physical 1 1 1 Two-hybrid
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex physical 1 1 1 Affinity Capture-MS
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Dosage Lethality
DOC1 YGL240W Processivity factor genetic 1 1 1 Dosage Lethality
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family genetic 1 1 1 Dosage Rescue
RPS24A YER074W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Positive Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex physical 1 1 1 Two-hybrid
NHP6A YPR052C High-mobility group (HMG) protein genetic 1 1 1 Dosage Rescue
SMC2 YFR031C Subunit of the condensin complex physical 1 1 1 Two-hybrid
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Dosage Lethality
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
RPL20B YOR312C Ribosomal 60S subunit protein L20B genetic 1 1 1 Dosage Lethality
RPS1B YML063W Ribosomal protein of the small (40S) subunit genetic 1 1 1 Dosage Lethality
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Growth Defect
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease physical 1 1 1 Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 1 1 1 Phenotypic Suppression
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Dosage Rescue
IOC2 YLR095C Subunit of the Isw1b complex physical 1 1 1 Affinity Capture-MS
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Dosage Lethality
NIS1 YNL078W Protein involved in axial bud site selection physical 1 1 1 Two-hybrid
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Phenotypic Enhancement
RAD5 YLR032W DNA helicase/Ubiquitin ligase physical 1 1 1 Two-hybrid
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome genetic 1 1 1 Dosage Lethality
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Dosage Lethality
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Dosage Lethality
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Dosage Lethality
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Dosage Lethality
MRPS9 YBR146W Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
RSM22 YKL155C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Dosage Rescue
SML1 YML058W Ribonucleotide reductase inhibitor genetic 1 1 1 Synthetic Rescue
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Synthetic Lethality
RAD2 YGR258C Single-stranded DNA endonuclease physical 1 1 1 Two-hybrid
CAT8 YMR280C Zinc cluster transcriptional activator physical 1 1 1 Affinity Capture-MS
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Two-hybrid
JEM1 YJL073W DnaJ-like chaperone required for nuclear membrane fusion during mating physical 1 1 1 Affinity Capture-MS
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 1 1 1 Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing physical 1 1 1 Two-hybrid
ORC5 YNL261W Subunit of the origin recognition complex (ORC) genetic 1 1 1 Synthetic Lethality
SNM1 YDR478W Ribonuclease MRP complex subunit genetic 1 1 1 Negative Genetic
DFG5 YMR238W Putative mannosidase genetic 1 1 1 Dosage Lethality
MSB3 YNL293W Rab GTPase-activating protein genetic 1 1 1 Dosage Lethality
NIP100 YPL174C Large subunit of the dynactin complex genetic 1 1 1 Synthetic Growth Defect
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
CCH1 YGR217W Voltage-gated high-affinity calcium channel genetic 1 1 1 Dosage Lethality
BSD2 YBR290W Heavy metal ion homeostasis protein genetic 1 1 1 Dosage Lethality
MFA2 YNL145W Mating pheromone a-factor genetic 1 1 1 Negative Genetic
KAP120 YPL125W Karyopherin responsible for the nuclear import of Rpf1p genetic 1 1 1 Dosage Lethality
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Dosage Lethality
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Growth Defect
PDR12 YPL058C Plasma membrane ATP-binding cassette (ABC) transporter physical 1 1 1 Affinity Capture-MS
GDH3 YAL062W NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Dosage Lethality
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Dosage Lethality
OKP1 YGR179C Outer kinetochore protein required for accurate chromosome segregation genetic 1 1 1 Positive Genetic
PLP2 YOR281C Protein that interacts with the CCT complex to stimulate actin folding physical 1 1 1 Two-hybrid
HCM1 YCR065W Forkhead transcription factor genetic 1 1 1 Positive Genetic
CBS2 YDR197W Mitochondrial translational activator of the COB mRNA genetic 1 1 1 Negative Genetic
HSP31 YDR533C Methylglyoxalase that converts methylglyoxal to D-lactate genetic 1 1 1 Dosage Lethality
BUD22 YMR014W Protein required for rRNA maturation and ribosomal subunit biogenesis genetic 1 1 1 Dosage Lethality
ASG7 YJL170C Protein that regulates signaling from G protein beta subunit Ste4p physical 1 1 1 Two-hybrid
BNS1 YGR230W Protein of unknown function physical 1 1 1 Two-hybrid
COX15 YER141W Heme a synthase physical 1 1 1 Two-hybrid
DUS3 YLR401C Dihydrouridine synthase physical 1 1 1 Two-hybrid
EGT2 YNL327W Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase physical 1 1 1 Two-hybrid
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family physical 1 1 1 Two-hybrid
HEM14 YER014W Protoporphyrinogen oxidase physical 1 1 1 Two-hybrid
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes physical 1 1 1 Two-hybrid
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation physical 1 1 1 Two-hybrid
MEI5 YPL121C Meiosis-specific protein involved in meiotic recombination physical 1 1 1 Two-hybrid
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair physical 1 1 1 Two-hybrid
NDJ1 YOL104C Protein that regulates meiotic SPB cohesion and telomere clustering physical 1 1 1 Two-hybrid
ORC6 YHR118C Subunit of the origin recognition complex (ORC) physical 1 1 1 Two-hybrid
PDR11 YIL013C ATP-binding cassette (ABC) transporter physical 1 1 1 Two-hybrid
SIA1 YOR137C Protein of unassigned function physical 1 1 1 Two-hybrid
SSU1 YPL092W Plasma membrane sulfite pump involved in sulfite metabolism physical 1 1 1 Two-hybrid
SWA2 YDR320C Auxilin-like protein involved in vesicular transport physical 1 1 1 Two-hybrid
TOA1 YOR194C TFIIA large subunit physical 1 1 1 Two-hybrid
TOP2 YNL088W Topoisomerase II physical 1 1 1 Two-hybrid
UBP1 YDL122W Ubiquitin-specific protease physical 1 1 1 Two-hybrid
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Two-hybrid
UBR1 YGR184C E3 ubiquitin ligase (N-recognin) physical 1 1 1 Two-hybrid
UBX3 YDL091C Clathrin-coated vesicle component, regulator of endocytosis physical 1 1 1 Two-hybrid
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins physical 1 1 1 Two-hybrid
ULP2 YIL031W Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins genetic 1 1 1 Phenotypic Suppression
YGK1 YGL101W 5'-deoxynucleotidase physical 1 1 1 Two-hybrid
YIL161W YIL161W Putative protein of unknown function physical 1 1 1 Two-hybrid
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Synthetic Lethality
YGR054W YGR054W Eukaryotic initiation factor eIF2A physical 1 1 1 Affinity Capture-MS
TYC1 YBR296C-A Inhibitor of the Anaphase-Promoting Complex/Cyclosome (APC/C) physical 1 1 1 PCA
TAR1 YLR154W-C Protein potentially involved in regulation of respiratory metabolism physical 1 1 1 Two-hybrid
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 1 1 1 Affinity Capture-MS
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit physical 1 1 1 Affinity Capture-MS
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit physical 1 1 1 Affinity Capture-MS
TFC1 YBR123C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
WHI4 YDL224C Putative RNA binding protein physical 1 1 1 Affinity Capture-MS
YDR316W-B YDR316W-B Retrotransposon TYA Gag and TYB Pol genes physical 1 1 1 Affinity Capture-MS
YGR126W YGR126W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Positive Genetic
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Positive Genetic
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Phenotypic Enhancement
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Phenotypic Enhancement
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Synthetic Growth Defect
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Synthetic Growth Defect
SSQ1 YLR369W Mitochondrial hsp70-type molecular chaperone genetic 1 1 1 Dosage Lethality
TOM5 YPR133W-A Component of the TOM (translocase of outer membrane) complex genetic 1 1 1 Dosage Lethality
TSR2 YLR435W Protein with a potential role in pre-rRNA processing genetic 1 1 1 Dosage Lethality
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Dosage Lethality
SSF1 YHR066W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Dosage Lethality
STB5 YHR178W Transcription factor genetic 1 1 1 Dosage Lethality
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Dosage Lethality
TRM10 YOL093W tRNA methyltransferase genetic 1 1 1 Dosage Lethality
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Dosage Lethality
TIF3 YPR163C Translation initiation factor eIF-4B genetic 1 1 1 Dosage Lethality
VMA16 YHR026W Subunit c'' of the vacuolar ATPase genetic 1 1 1 Dosage Lethality
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Dosage Lethality
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Dosage Lethality
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 1 1 1 Dosage Lethality
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Dosage Lethality
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Dosage Lethality
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Dosage Lethality
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Dosage Lethality
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Dosage Lethality
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 1 1 1 Dosage Lethality
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Dosage Lethality
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Dosage Lethality
VPS28 YPL065W Component of the ESCRT-I complex genetic 1 1 1 Dosage Lethality
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 1 1 1 Dosage Lethality
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 1 1 1 Dosage Lethality
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Dosage Lethality
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 1 1 1 Dosage Lethality
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Dosage Lethality
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Dosage Lethality
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Dosage Lethality
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Dosage Lethality
VPS60 YDR486C Protein involved in late endosome to vacuole transport genetic 1 1 1 Dosage Lethality
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 1 1 1 Dosage Lethality
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 1 1 1 Dosage Lethality
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Dosage Lethality
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Dosage Lethality
THI20 YOL055C Trifunctional enzyme of thiamine biosynthesis, degradation and salvage genetic 1 1 1 Dosage Lethality
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Dosage Lethality
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Dosage Lethality
YVH1 YIR026C Dual specificity protein phosphatase genetic 1 1 1 Dosage Lethality
YCR051W YCR051W Putative protein of unknown function genetic 1 1 1 Dosage Lethality
YGL242C YGL242C Protein of unknown function genetic 1 1 1 Dosage Lethality
YNR068C YNR068C Putative protein of unknown function genetic 1 1 1 Dosage Lethality
UBC11 YOR339C Ubiquitin-conjugating enzyme genetic 1 1 1 Dosage Rescue
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Dosage Rescue
TAF3 YPL011C TFIID subunit (47 kDa) genetic 1 1 1 Dosage Rescue
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Dosage Rescue
UBP7 YIL156W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions genetic 1 1 1 Dosage Rescue
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Positive Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 1 1 1 Negative Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 1 1 1 Positive Genetic
UTP15 YMR093W Nucleolar protein genetic 1 1 1 Positive Genetic
CST26 YBR042C Acyltransferase physical 1 1 1 Two-hybrid
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p physical 1 1 1 Two-hybrid
HEH2 YDR458C Inner nuclear membrane (INM) protein physical 1 1 1 Two-hybrid
SMN1 YHR202W Putative AMP hydrolase physical 1 1 1 Two-hybrid
JHD2 YJR119C JmjC domain family histone demethylase physical 1 1 1 Two-hybrid
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 physical 1 1 1 Two-hybrid
GAT2 YMR136W Protein containing GATA family zinc finger motifs physical 1 1 1 Two-hybrid
AIM45 YPR004C Putative ortholog of mammalian ETF-alpha genetic 1 1 1 Dosage Lethality
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Negative Genetic
KEX1 YGL203C Cell death protease essential for hypochlorite-induced apoptosis genetic 1 1 1 Dosage Lethality
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Positive Genetic
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Dosage Lethality
ATP14 YLR295C Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Lethality
ATP15 YPL271W Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase genetic 1 1 1 Dosage Lethality
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
MRPL11 YDL202W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 1 1 1 Negative Genetic
PUF4 YGL014W Member of the PUF protein family physical 1 1 1 Affinity Capture-RNA
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Affinity Capture-MS
LCB5 YLR260W Minor sphingoid long-chain base kinase genetic 1 1 1 Dosage Lethality
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Synthetic Growth Defect
NDT80 YHR124W Meiosis-specific transcription factor genetic 1 1 1 Phenotypic Suppression
RSM24 YDR175C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Dosage Lethality
RTC3 YHR087W Protein of unknown function involved in RNA metabolism genetic 1 1 1 Dosage Lethality
FTR1 YER145C High affinity iron permease genetic 1 1 1 Dosage Lethality
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Dosage Lethality
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Dosage Rescue
SLX4 YLR135W Endonuclease involved in processing DNA genetic 1 1 1 Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 1 1 1 Negative Genetic
MRPL22 YNL177C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites genetic 1 1 1 Dosage Rescue
ISM1 YPL040C Mitochondrial isoleucyl-tRNA synthetase genetic 1 1 1 Dosage Lethality
KRE28 YDR532C Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Dosage Lethality
RMA1 YKL132C Putative dihydrofolate synthetase genetic 1 1 1 Negative Genetic
RRG1 YDR065W Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
GEP5 YLR091W Protein of unknown function genetic 1 1 1 Dosage Lethality
RPL24A YGL031C Ribosomal 60S subunit protein L24A genetic 1 1 1 Dosage Lethality
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 1 1 1 Phenotypic Enhancement
RPS10A YOR293W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
MRPL27 YBR282W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
RPL19A YBR084C-A Ribosomal 60S subunit protein L19A genetic 1 1 1 Dosage Lethality
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
GGC1 YDL198C Mitochondrial GTP/GDP transporter genetic 1 1 1 Dosage Lethality
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Dosage Lethality
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Lethality
RTT106 YNL206C Histone chaperone genetic 1 1 1 Dosage Rescue
RKM4 YDR257C Ribosomal lysine methyltransferase genetic 1 1 1 Dosage Rescue
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Dosage Lethality
PCK1 YKR097W Phosphoenolpyruvate carboxykinase physical 1 1 1 Affinity Capture-MS
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity physical 1 1 1 Affinity Capture-MS
RAD57 YDR004W Protein that stimulates strand exchange physical 1 1 1 Reconstituted Complex
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 1 1 1 Dosage Lethality
SPO14 YKR031C Phospholipase D physical 1 1 1 Affinity Capture-MS
CPD1 YGR247W Cyclic nucleotide phosphodiesterase genetic 1 1 1 Dosage Rescue
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Phenotypic Suppression
RSA1 YPL193W Protein involved in the assembly of 60S ribosomal subunits genetic 1 1 1 Dosage Lethality
MET7 YOR241W Folylpolyglutamate synthetase genetic 1 1 1 Dosage Lethality
RPL31B YLR406C Ribosomal 60S subunit protein L31B genetic 1 1 1 Dosage Lethality
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 1 1 1 Dosage Lethality
BAP2 YBR068C High-affinity leucine permease genetic 1 1 1 Dosage Rescue
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 1 1 1 Negative Genetic
PPS1 YBR276C Protein phosphatase genetic 1 1 1 Dosage Rescue
DUS4 YLR405W Dihydrouridine synthase genetic 1 1 1 Dosage Lethality
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Dosage Lethality
GRE2 YOL151W 3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase genetic 1 1 1 Dosage Lethality
MRX14 YDR115W Putative mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
FMP33 YJL161W Putative protein of unknown function genetic 1 1 1 Dosage Lethality
MRPL37 YBR268W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Dosage Lethality
MSM1 YGR171C Mitochondrial methionyl-tRNA synthetase (MetRS) genetic 1 1 1 Dosage Lethality
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Dosage Lethality
PMP1 YCR024C-A Regulatory subunit for the plasma membrane H(+)-ATPase Pma1p genetic 1 1 1 Dosage Lethality
EMC2 YJR088C Member of conserved ER transmembrane complex genetic 1 1 1 Dosage Lethality
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Growth Defect
RRG9 YNL213C Protein of unknown function genetic 1 1 1 Synthetic Growth Defect
RTT105 YER104W Chaperone for Replication Protein A complex (RPA) genetic 1 1 1 Positive Genetic
QCR10 YHR001W-A Subunit of the ubiqunol-cytochrome c oxidoreductase complex genetic 1 1 1 Dosage Lethality
SFC1 YJR095W Mitochondrial succinate-fumarate transporter physical 1 1 1 Affinity Capture-MS
SLS1 YLR139C Mitochondrial membrane protein genetic 1 1 1 Dosage Lethality
OMA1 YKR087C Metalloendopeptidase of the mitochondrial inner membrane genetic 1 1 1 Dosage Lethality
RRF1 YHR038W Mitochondrial ribosome recycling factor genetic 1 1 1 Dosage Lethality
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Synthetic Growth Defect
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Dosage Rescue
RNP1 YLL046C Ribonucleoprotein that contains two RNA recognition motifs (RRM) genetic 1 1 1 Dosage Lethality
RRT8 YOL048C Protein involved in spore wall assembly genetic 1 1 1 Dosage Lethality
PTH4 YOL114C Protein similar to the human peptidyl-tRNA hydrolase gene ICT1 genetic 1 1 1 Dosage Rescue