Standard name Systematic name Name description Description
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p Nuclease subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; Mre11p associates with Ser/Thr-rich ORFs in premeiotic phase; nuclease activity required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress
Visualize the interactome of MRE11
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.409 0.458 0.614
Mito 0.267 0.243 NaN
Nucleus 0.280 0.292 0.333
Vac/Vac Memb 0.155 0.146 NaN
Budneck NaN NaN 0.059

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 432

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
MRE11 10 5 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p physical 34 7 29 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Two-hybrid, Co-localization, Co-localization, Affinity Capture-Western, Co-purification, Co-fractionation, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western
XRS2 YDR369C FHA domain-containing component of the Mre11 complex physical 32 6 27 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Co-purification, Affinity Capture-MS, Reconstituted Complex, Two-hybrid, Two-hybrid, Two-hybrid, Affinity Capture-Western, Far Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 27 6 25 Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Rescue, Phenotypic Enhancement, Negative Genetic, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Enhancement, Phenotypic Suppression, Dosage Rescue, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 20 6 18 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
SAE2 YGL175C Endonuclease required for telomere elongation genetic 17 6 15 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Lethality, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 17 5 12 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Dosage Growth Defect, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Suppression, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 16 2 13 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 13 4 10 Synthetic Lethality, Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 12 5 11 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Synthetic Growth Defect
BRE1 YDL074C E3 ubiquitin ligase genetic 10 3 7 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 9 4 7 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Dosage Lethality, Dosage Lethality, Negative Genetic, Synthetic Growth Defect
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 9 3 7 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 8 5 7 Synthetic Lethality, Dosage Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Rescue, Phenotypic Enhancement
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) genetic 8 4 7 Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Dosage Growth Defect, Phenotypic Suppression, Phenotypic Enhancement, Phenotypic Enhancement
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 8 4 6 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 7 5 7 Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality, Positive Genetic, Synthetic Rescue, Synthetic Growth Defect, Phenotypic Suppression
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 7 3 7 Phenotypic Enhancement, Negative Genetic, Synthetic Lethality, Phenotypic Enhancement, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality
RAD51 YER095W Strand exchange protein genetic 7 3 7 Synthetic Growth Defect, Phenotypic Enhancement, Positive Genetic, Positive Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 7 3 6 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 7 2 6 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 7 2 5 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 7 2 5 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 6 4 6 Phenotypic Suppression, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 6 5 5 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Negative Genetic, Dosage Lethality
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CTF4 YPR135W Chromatin-associated protein genetic 6 3 4 Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 6 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 6 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Phenotypic Enhancement, Synthetic Lethality
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 6 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
RNH203 YLR154C Ribonuclease H2 subunit genetic 6 3 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 5 4 5 Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Growth Defect, Synthetic Lethality
RIF1 YBR275C Protein involved in control of DNA replication genetic 5 4 5 Synthetic Growth Defect, Negative Genetic, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p physical 5 3 5 Two-hybrid, Two-hybrid, Reconstituted Complex, Two-hybrid, Affinity Capture-Western
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 5 4 4 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 5 3 4 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex genetic 5 2 4 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 5 4 3 Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Lethality, Synthetic Lethality, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 5 3 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 5 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
IRC5 YFR038W Putative ATPase containing the DEAD/H helicase-related sequence motif genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase physical 5 3 2 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid, Reconstituted Complex
SGT1 YOR057W Cochaperone protein genetic 5 3 2 Synthetic Lethality, Synthetic Lethality, Positive Genetic, Negative Genetic, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 5 4 1 Phenotypic Enhancement, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality
RAD52 YML032C Protein involved in homologous recombination genetic 4 4 4 Phenotypic Suppression, Phenotypic Enhancement, Synthetic Lethality, Positive Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 4 3 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Phenotypic Suppression
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 4 3 4 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Lethality
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 4 3 4 Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 4 2 4 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 4 2 4 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Positive Genetic
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 4 4 3 Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic, Synthetic Lethality
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 4 3 3 Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement, Negative Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 4 3 3 Phenotypic Enhancement, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
SMT3 YDR510W Ubiquitin-like protein of the SUMO family physical 4 3 3 Protein-peptide, Two-hybrid, Two-hybrid, Affinity Capture-Western
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 4 3 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GET1 YGL020C Subunit of the GET complex genetic 4 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Two-hybrid
SAE2 YGL175C Endonuclease required for telomere elongation physical 4 2 3 Far Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
RPN10 YHR200W Proteasome polyubiquitin receptor genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
MSH2 YOL090W Protein that binds to DNA mismatches genetic 4 2 3 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 4 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 4 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PSO2 YMR137C Nuclease required for DNA single- and double-strand break repair genetic 4 2 2 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Suppression
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 3 3 3 Negative Genetic, Synthetic Lethality, Synthetic Growth Defect
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RNH201 YNL072W Ribonuclease H2 catalytic subunit genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Lethality
CIK1 YMR198W Kinesin-associated protein genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
ULP1 YPL020C Protease that specifically cleaves Smt3p protein conjugates genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 3 3 2 Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) physical 3 3 2 Co-localization, Two-hybrid, Protein-peptide
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 3 3 2 Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 3 3 2 Negative Genetic, Synthetic Growth Defect, Synthetic Lethality
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 3 2 2 Synthetic Growth Defect, Negative Genetic, Negative Genetic
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 3 2 2 Negative Genetic, Synthetic Lethality, Synthetic Lethality
MSI1 YBR195C Subunit of chromatin assembly factor I (CAF-1) genetic 3 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 3 2 2 Negative Genetic, Negative Genetic, Synthetic Lethality
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 3 1 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
IRA2 YOL081W GTPase-activating protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SYG1 YIL047C Plasma membrane protein of unknown function genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PSK2 YOL045W PAS-domain containing serine/threonine protein kinase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SHE4 YOR035C Protein containing a UCS (UNC-45/CRO1/SHE4) domain genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FLO11 YIR019C GPI-anchored cell surface glycoprotein (flocculin) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex physical 3 2 1 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
RSC2 YLR357W Component of the RSC chromatin remodeling complex physical 3 2 1 Two-hybrid, Affinity Capture-Western, Affinity Capture-Western
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC14 YFR028C Protein phosphatase required for mitotic exit genetic 2 2 2 Phenotypic Suppression, Synthetic Lethality
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 2 2 Synthetic Lethality, Positive Genetic
CDC36 YDL165W Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 2 2 2 Synthetic Lethality, Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 2 2 2 Synthetic Lethality, Negative Genetic
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase physical 2 2 2 Affinity Capture-Western, Two-hybrid
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation physical 2 2 2 Reconstituted Complex, Affinity Capture-Western
RIF2 YLR453C Protein that binds to the Rap1p C-terminus genetic 2 2 2 Phenotypic Suppression, Phenotypic Enhancement
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 2 2 2 Phenotypic Enhancement, Positive Genetic
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 2 2 2 Negative Genetic, Synthetic Lethality
RDH54 YBR073W DNA-dependent ATPase genetic 2 2 2 Negative Genetic, Phenotypic Suppression
SLX5 YDL013W Subunit of the Slx5-Slx8 SUMO-targeted Ub ligase (STUbL) complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
SLX8 YER116C Subunit of Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NFS1 YCL017C Cysteine desulfurase involved in iron-sulfur cluster biogenesis genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 2 2 Synthetic Lethality, Negative Genetic
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome genetic 2 2 2 Synthetic Lethality, Positive Genetic
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 2 2 2 Synthetic Lethality, Positive Genetic
ORC1 YML065W Largest subunit of the origin recognition complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SRV2 YNL138W CAP (cyclase-associated protein) genetic 2 2 2 Synthetic Lethality, Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 2 2 2 Synthetic Lethality, Synthetic Growth Defect
FOB1 YDR110W Nucleolar protein that binds the rDNA replication fork barrier site genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 2 2 2 Negative Genetic, Phenotypic Suppression
IRC19 YLL033W Protein of unknown function genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 2 1 2 Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Negative Genetic, Negative Genetic
DST1 YGL043W General transcription elongation factor TFIIS genetic 2 1 2 Negative Genetic, Negative Genetic
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 2 1 2 Negative Genetic, Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 2 1 2 Positive Genetic, Positive Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 2 1 2 Negative Genetic, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
CHS1 YNL192W Chitin synthase I genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway physical 2 1 2 Two-hybrid, Two-hybrid
NFI1 YOR156C SUMO E3 ligase physical 2 1 2 Two-hybrid, Two-hybrid
UBP6 YFR010W Ubiquitin-specific protease genetic 2 1 2 Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 2 1 2 Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 2 1 2 Negative Genetic, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
RFC1 YOR217W Subunit of heteropentameric Replication factor C (RF-C) genetic 2 1 2 Negative Genetic, Negative Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 1 2 Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
TSC11 YER093C Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p) genetic 2 1 2 Negative Genetic, Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 2 1 2 Negative Genetic, Negative Genetic
TOR2 YKL203C PIK-related protein kinase and rapamycin target genetic 2 1 2 Negative Genetic, Negative Genetic
YJR124C YJR124C Putative protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 2 1 2 Negative Genetic, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 2 1 2 Negative Genetic, Negative Genetic
FIR1 YER032W Protein involved in 3' mRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
CHS5 YLR330W Component of the exomer complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HRQ1 YDR291W 3'-5' DNA helicase of the conserved RecQ family genetic 2 1 2 Negative Genetic, Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 2 1 2 Negative Genetic, Negative Genetic
IFM1 YOL023W Mitochondrial translation initiation factor 2 genetic 2 1 2 Negative Genetic, Negative Genetic
SPO13 YHR014W Meiotic regulator genetic 2 2 1 Phenotypic Enhancement, Phenotypic Suppression
SNF2 YOR290C Catalytic subunit of the SWI/SNF chromatin remodeling complex genetic 2 2 1 Synthetic Growth Defect, Phenotypic Enhancement
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 2 1 Phenotypic Suppression, Synthetic Growth Defect
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 2 1 Synthetic Lethality, Synthetic Growth Defect
IRC20 YLR247C E3 ubiquitin ligase and putative helicase genetic 2 2 1 Phenotypic Suppression, Synthetic Rescue
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 2 1 1 Negative Genetic, Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RAD18 YCR066W E3 ubiquitin ligase physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
PAC11 YDR488C Dynein intermediate chain, microtubule motor protein genetic 2 1 1 Negative Genetic, Negative Genetic
RPL16A YIL133C Ribosomal 60S subunit protein L16A genetic 2 1 1 Negative Genetic, Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 2 1 1 Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 1 Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NAT1 YDL040C Subunit of protein N-terminal acetyltransferase NatA genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
NPT1 YOR209C Nicotinate phosphoribosyltransferase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 2 1 1 Negative Genetic, Negative Genetic
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 2 1 1 Negative Genetic, Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 2 1 1 Synthetic Lethality, Synthetic Lethality
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 2 1 1 Negative Genetic, Negative Genetic
ORC2 YBR060C Subunit of the origin recognition complex (ORC) genetic 2 1 1 Negative Genetic, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 2 1 1 Negative Genetic, Negative Genetic
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
HUB1 YNR032C-A Ubiquitin-like protein modifier genetic 2 1 1 Negative Genetic, Negative Genetic
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ELO1 YJL196C Elongase I, medium-chain acyl elongase genetic 2 1 1 Negative Genetic, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci regulation 1 1 1 chromatin immunoprecipitation-chip evidence
STP1 YDR463W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP6 YDR259C Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CEF1 YMR213W Essential splicing factor genetic 1 1 1 Synthetic Lethality
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
EBP2 YKL172W Required for 25S rRNA maturation and 60S ribosomal subunit assembly genetic 1 1 1 Negative Genetic
GCD6 YDR211W Catalytic epsilon subunit of the translation initiation factor eIF2B genetic 1 1 1 Synthetic Lethality
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
GCD2 YGR083C Delta subunit of the translation initiation factor eIF2B genetic 1 1 1 Synthetic Lethality
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Positive Genetic
AAR2 YBL074C Component of the U5 snRNP complex genetic 1 1 1 Synthetic Lethality
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
ABD1 YBR236C Methyltransferase genetic 1 1 1 Positive Genetic
ADE13 YLR359W Adenylosuccinate lyase genetic 1 1 1 Synthetic Lethality
APC1 YNL172W Largest subunit of the Anaphase-Promoting Complex/Cyclosome physical 1 1 1 Two-hybrid
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Synthetic Lethality
BOI2 YER114C Protein involved in polar growth genetic 1 1 1 Synthetic Growth Defect
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 1 1 1 Positive Genetic
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Synthetic Lethality
AVO1 YOL078W Component of the membrane-bound TORC2 complex genetic 1 1 1 Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Synthetic Lethality
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
CUS1 YMR240C Protein required for assembly of U2 snRNP into the spliceosome genetic 1 1 1 Synthetic Lethality
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Affinity Capture-MS
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
FAP1 YNL023C Protein that binds to Fpr1p physical 1 1 1 Two-hybrid
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
HRT1 YOL133W RING-H2 domain core subunit of multiple ubiquitin ligase complexes genetic 1 1 1 Synthetic Lethality
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 1 1 1 Negative Genetic
CRM1 YGR218W Nuclear export factor, exportin physical 1 1 1 Affinity Capture-MS
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Synthetic Growth Defect
LST8 YNL006W Protein required for the transport of Gap1p genetic 1 1 1 Synthetic Lethality
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 1 1 1 Phenotypic Enhancement
IMG1 YCR046C Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
GEP3 YOR205C Protein required for mitochondrial ribosome small subunit biogenesis genetic 1 1 1 Synthetic Growth Defect
CMD1 YBR109C Calmodulin genetic 1 1 1 Negative Genetic
AFG2 YLR397C ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex genetic 1 1 1 Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Negative Genetic
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Phenotypic Enhancement
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Lethality
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
MED8 YBR193C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Negative Genetic
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family genetic 1 1 1 Synthetic Lethality
CDC25 YLR310C Membrane bound guanine nucleotide exchange factor genetic 1 1 1 Negative Genetic
BOI1 YBL085W Protein involved in polar growth, functionally redundant with Boi2p genetic 1 1 1 Synthetic Growth Defect
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Phenotypic Suppression
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Synthetic Lethality
HTB1 YDR224C Histone H2B genetic 1 1 1 Synthetic Growth Defect
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 1 1 1 Negative Genetic
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 1 1 1 Synthetic Rescue
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 1 1 1 Negative Genetic
CCT5 YJR064W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair physical 1 1 1 Affinity Capture-MS
ILV3 YJR016C Dihydroxyacid dehydratase genetic 1 1 1 Synthetic Lethality
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) genetic 1 1 1 Negative Genetic
FUM1 YPL262W Fumarase genetic 1 1 1 Dosage Rescue
FHL1 YPR104C Regulator of ribosomal protein (RP) transcription genetic 1 1 1 Synthetic Lethality
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export genetic 1 1 1 Synthetic Lethality
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 1 1 1 Synthetic Lethality
CTF13 YMR094W Subunit of the CBF3 complex genetic 1 1 1 Synthetic Lethality
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) physical 1 1 1 Two-hybrid
HHT1 YBR010W Histone H3 genetic 1 1 1 Synthetic Rescue
IRA1 YBR140C GTPase-activating protein genetic 1 1 1 Synthetic Lethality
MSH5 YDL154W Protein of the MutS family physical 1 1 1 Two-hybrid
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 1 1 1 Phenotypic Suppression
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex physical 1 1 1 Two-hybrid
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC2 YLR357W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex physical 1 1 1 Affinity Capture-Western
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RSC4 YKR008W Component of the RSC chromatin remodeling complex physical 1 1 1 Affinity Capture-Western
RSC4 YKR008W Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Lethality
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Synthetic Lethality
YBL044W YBL044W Putative protein of unknown function physical 1 1 1 Affinity Capture-MS
SPA2 YLL021W Component of the polarisome physical 1 1 1 Affinity Capture-MS
YKU80 YMR106C Subunit of telomeric Ku complex (Yku70p-Yku80p) physical 1 1 1 Two-hybrid
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor physical 1 1 1 Affinity Capture-RNA
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Growth Defect
UBC9 YDL064W SUMO-conjugating enzyme involved in the Smt3p conjugation pathway genetic 1 1 1 Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family physical 1 1 1 Two-hybrid
RIF2 YLR453C Protein that binds to the Rap1p C-terminus physical 1 1 1 Reconstituted Complex
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) physical 1 1 1 Two-hybrid
NEJ1 YLR265C DNA end-binding protein required for nonhomologous end joining (NHEJ) genetic 1 1 1 Phenotypic Suppression
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Synthetic Growth Defect
RAD24 YER173W Checkpoint protein genetic 1 1 1 Phenotypic Enhancement
TDP1 YBR223C Tyrosyl-DNA phosphodiesterase I genetic 1 1 1 Phenotypic Enhancement
NUP120 YKL057C Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 1 1 1 Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 1 1 1 Negative Genetic
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
TFA2 YKR062W TFIIE small subunit genetic 1 1 1 Negative Genetic
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Negative Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
TIM13 YGR181W Mitochondrial intermembrane space protein genetic 1 1 1 Positive Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Positive Genetic
PHB1 YGR132C Subunit of the prohibitin complex (Phb1p-Phb2p) genetic 1 1 1 Synthetic Growth Defect
YFH1 YDL120W Mitochondrial matrix iron chaperone genetic 1 1 1 Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Negative Genetic
YND1 YER005W Apyrase with wide substrate specificity genetic 1 1 1 Negative Genetic
UBC6 YER100W Ubiquitin-conjugating enzyme involved in ERAD genetic 1 1 1 Negative Genetic
SLO1 YER180C-A Protein interacting with Arl3p genetic 1 1 1 Negative Genetic
MSC1 YML128C Protein of unknown function genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Negative Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Synthetic Lethality
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Synthetic Growth Defect
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 1 1 1 Synthetic Growth Defect
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Synthetic Growth Defect
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Growth Defect
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Synthetic Growth Defect
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Synthetic Growth Defect
MTQ2 YDR140W S-adenosylmethionine-dependent methyltransferase genetic 1 1 1 Synthetic Growth Defect
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Growth Defect
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RMD9 YGL107C Mitochondrial protein that controls mitochondrial gene expression genetic 1 1 1 Synthetic Growth Defect
VPS15 YBR097W Serine/threonine protein kinase involved in vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
SWI6 YLR182W Transcription cofactor genetic 1 1 1 Synthetic Lethality
SIS2 YKR072C Negative regulatory subunit of protein phosphatase 1 (Ppz1p) genetic 1 1 1 Dosage Growth Defect
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif genetic 1 1 1 Positive Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
MSS11 YMR164C Transcription factor genetic 1 1 1 Negative Genetic
PML1 YLR016C Subunit of the RES complex genetic 1 1 1 Negative Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Negative Genetic
SGF29 YCL010C Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes genetic 1 1 1 Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 1 1 1 Negative Genetic
NUM1 YDR150W Protein required for nuclear migration genetic 1 1 1 Negative Genetic
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
RTT106 YNL206C Histone chaperone genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Negative Genetic
VPS75 YNL246W NAP family histone chaperone genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Synthetic Lethality
PRP45 YAL032C Protein required for pre-mRNA splicing genetic 1 1 1 Synthetic Lethality
MTW1 YAL034W-A Essential component of the MIND kinetochore complex genetic 1 1 1 Synthetic Lethality
STU1 YBL034C Microtubule plus-end-tracking non-motor protein genetic 1 1 1 Synthetic Lethality
RPL32 YBL092W Ribosomal 60S subunit protein L32 genetic 1 1 1 Synthetic Lethality
PKC1 YBL105C Protein serine/threonine kinase genetic 1 1 1 Synthetic Lethality
TSC3 YBR058C-A Protein that stimulates the activity of serine palmitoyltransferase genetic 1 1 1 Synthetic Lethality
TSC10 YBR265W 3-ketosphinganine reductase genetic 1 1 1 Synthetic Lethality
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 1 1 1 Synthetic Lethality
NHP2 YDL208W Protein related to mammalian high mobility group (HMG) proteins genetic 1 1 1 Synthetic Lethality
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Synthetic Lethality
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Synthetic Lethality
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Synthetic Lethality
SRP101 YDR292C Signal recognition particle (SRP) receptor alpha subunit genetic 1 1 1 Synthetic Lethality
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex genetic 1 1 1 Synthetic Lethality
PMI40 YER003C Mannose-6-phosphate isomerase genetic 1 1 1 Synthetic Lethality
SPT15 YER148W TATA-binding protein (TBP) genetic 1 1 1 Synthetic Lethality
SPB4 YFL002C Putative ATP-dependent RNA helicase genetic 1 1 1 Synthetic Lethality
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Synthetic Lethality
YPT1 YFL038C Rab family GTPase genetic 1 1 1 Synthetic Lethality
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Synthetic Lethality
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Synthetic Lethality
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Synthetic Lethality
USE1 YGL098W Essential SNARE protein localized to the ER genetic 1 1 1 Synthetic Lethality
VHT1 YGR065C High-affinity plasma membrane H+-biotin (vitamin H) symporter genetic 1 1 1 Synthetic Lethality
RRP46 YGR095C Exosome non-catalytic core component genetic 1 1 1 Synthetic Lethality
TEL2 YGR099W Subunit of the ASTRA complex, involved in chromatin remodeling genetic 1 1 1 Synthetic Lethality
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 1 1 1 Synthetic Lethality
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Synthetic Lethality
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Synthetic Lethality
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Synthetic Lethality
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Lethality
TIM17 YJL143W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Synthetic Lethality
NPA3 YJR072C Member of the conserved GPN-loop GTPase family genetic 1 1 1 Synthetic Lethality
SPC42 YKL042W Central plaque component of spindle pole body (SPB) genetic 1 1 1 Synthetic Lethality
SFI1 YLL003W Centrin (Cdc31p)-binding protein required for SPB duplication genetic 1 1 1 Synthetic Lethality
NOC3 YLR002C Subunit of a nuclear complex with Noc2p and pre-replicative complexes genetic 1 1 1 Synthetic Lethality
SDO1 YLR022C Guanine nucleotide exchange factor (GEF) for Ria1p genetic 1 1 1 Synthetic Lethality
MSL5 YLR116W Component of commitment complex genetic 1 1 1 Synthetic Lethality
YHC1 YLR298C Component of the U1 snRNP complex required for pre-mRNA splicing genetic 1 1 1 Synthetic Lethality
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Synthetic Lethality
SEC39 YLR440C Component of the Dsl1p tethering complex genetic 1 1 1 Synthetic Lethality
UTP14 YML093W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Synthetic Lethality
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 1 1 1 Synthetic Lethality
TAF7 YMR227C TFIID subunit (67 kDa) genetic 1 1 1 Synthetic Lethality
RRP5 YMR229C RNA binding protein involved in synthesis of 18S and 5.8S rRNAs genetic 1 1 1 Synthetic Lethality
RNT1 YMR239C Nuclear dsRNA-specific ribonuclease (RNase III) genetic 1 1 1 Synthetic Lethality
PSE1 YMR308C Karyopherin/importin that interacts with the nuclear pore complex genetic 1 1 1 Synthetic Lethality
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Synthetic Lethality
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Synthetic Lethality
TRM112 YNR046W Protein involved in methylation of tRNA, rRNA, and translation factors genetic 1 1 1 Synthetic Lethality
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Synthetic Lethality
NUF2 YOL069W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Synthetic Lethality
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase genetic 1 1 1 Synthetic Lethality
TPT1 YOL102C tRNA 2'-phosphotransferase that catalyzes final step in tRNA splicing genetic 1 1 1 Synthetic Lethality
NOB1 YOR056C Protein involved in proteasomal and 40S ribosomal subunit biogenesis genetic 1 1 1 Synthetic Lethality
PNO1 YOR145C Essential nucleolar protein required for pre-18S rRNA processing genetic 1 1 1 Synthetic Lethality
RET1 YOR207C Second-largest subunit of RNA polymerase III genetic 1 1 1 Synthetic Lethality
RPA43 YOR340C RNA polymerase I subunit A43 genetic 1 1 1 Synthetic Lethality
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Synthetic Lethality
PRP46 YPL151C Member of the NineTeen Complex (NTC) genetic 1 1 1 Synthetic Lethality
NSL1 YPL233W Essential component of the MIND kinetochore complex genetic 1 1 1 Synthetic Lethality
YAH1 YPL252C Ferredoxin of the mitochondrial matrix genetic 1 1 1 Synthetic Lethality
SUA7 YPR086W Transcription factor TFIIB genetic 1 1 1 Synthetic Lethality
NOC4 YPR144C Nucleolar protein genetic 1 1 1 Synthetic Lethality
PRP4 YPR178W Splicing factor genetic 1 1 1 Synthetic Lethality
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 1 1 1 Phenotypic Suppression
UAF30 YOR295W Subunit of UAF (upstream activation factor) complex genetic 1 1 1 Synthetic Lethality
NUP170 YBL079W Subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Synthetic Growth Defect
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 1 1 1 Synthetic Growth Defect
RPB2 YOR151C RNA polymerase II second largest subunit B150 genetic 1 1 1 Synthetic Growth Defect
RPB9 YGL070C RNA polymerase II subunit B12.6 genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
NUS1 YDL193W Forms dehydrodolichyl diphosphate synthase complex with RER2 or SRT1 genetic 1 1 1 Positive Genetic
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 1 1 1 Positive Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
URA6 YKL024C Uridylate kinase genetic 1 1 1 Positive Genetic
SEC65 YML105C Subunit of the signal recognition particle (SRP) genetic 1 1 1 Positive Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Positive Genetic
OST2 YOR103C Epsilon subunit of the oligosaccharyltransferase complex genetic 1 1 1 Positive Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Positive Genetic
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Positive Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Negative Genetic
TIP20 YGL145W Peripheral membrane protein required for COPI vesicle fusion to the ER genetic 1 1 1 Negative Genetic
UTP18 YJL069C Small-subunit processome protein involved in pre-18S rRNA maturation genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
TAH11 YJR046W DNA replication licensing factor genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Negative Genetic
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Negative Genetic
UTP5 YDR398W Subunit of U3-containing Small Subunit (SSU) processome complex genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
PRI1 YIR008C Subunit of DNA primase genetic 1 1 1 Negative Genetic
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Negative Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 1 1 1 Negative Genetic
RSC58 YLR033W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ORC4 YPR162C Subunit of the origin recognition complex (ORC) genetic 1 1 1 Negative Genetic
YBP1 YBR216C Protein involved in cellular response to oxidative stress genetic 1 1 1 Negative Genetic
YBR298C-A YBR298C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
MRP10 YDL045W-A Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
NSI1 YDR026C RNA polymerase I termination factor genetic 1 1 1 Negative Genetic
TVP23 YDR084C Integral membrane protein genetic 1 1 1 Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 1 1 1 Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 1 1 1 Negative Genetic
MSC2 YDR205W Endoplasmic reticulum zinc transporter genetic 1 1 1 Negative Genetic
MRPL35 YDR322W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Negative Genetic
RML2 YEL050C Mitochondrial ribosomal protein of the large subunit (L2) genetic 1 1 1 Negative Genetic
SOM1 YEL059C-A Subunit of the mitochondrial inner membrane peptidase (IMP) genetic 1 1 1 Negative Genetic
PAU5 YFL020C Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 1 1 1 Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase genetic 1 1 1 Negative Genetic
NOT3 YIL038C Component of the CCR4-NOT core complex, involved in mRNA decapping genetic 1 1 1 Negative Genetic
PET130 YJL023C Protein of unknown function genetic 1 1 1 Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 1 1 1 Negative Genetic
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Negative Genetic
YKR041W YKR041W Protein of unknown function genetic 1 1 1 Negative Genetic
TUS1 YLR425W Guanine nucleotide exchange factor (GEF) that modulates Rho1p activity genetic 1 1 1 Negative Genetic
SMA2 YML066C Meiosis-specific prospore membrane protein genetic 1 1 1 Negative Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
RPS6A YPL090C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
SCH9 YHR205W AGC family protein kinase genetic 1 1 1 Synthetic Growth Defect
SWS2 YNL081C Putative mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
YNL134C YNL134C NADH-dependent aldehyde reductase genetic 1 1 1 Negative Genetic
SLA2 YNL243W Adaptor protein that links actin to clathrin and endocytosis genetic 1 1 1 Negative Genetic
SOL1 YNR034W Protein with a possible role in tRNA export genetic 1 1 1 Negative Genetic
RSM19 YNR037C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 1 1 1 Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 1 1 1 Negative Genetic
YOR296W YOR296W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPL11A YPR102C Ribosomal 60S subunit protein L11A genetic 1 1 1 Positive Genetic
SSK2 YNR031C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
UBP12 YJL197W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
SSK22 YCR073C MAP kinase kinase kinase of HOG1 mitogen-activated signaling pathway genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 1 1 1 Positive Genetic
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Synthetic Lethality
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 1 1 1 Negative Genetic
ROX1 YPR065W Heme-dependent repressor of hypoxic genes genetic 1 1 1 Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 1 1 1 Negative Genetic
ZIP2 YGL249W Meiosis-specific protein genetic 1 1 1 Negative Genetic
TRS65 YGR166W Component of transport protein particle (TRAPP) complex II genetic 1 1 1 Positive Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
SMC5 YOL034W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 1 1 1 Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 1 1 1 Synthetic Growth Defect
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Dosage Growth Defect
SRN2 YLR119W Component of the ESCRT-I complex genetic 1 1 1 Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
LHS1 YKL073W Molecular chaperone of the endoplasmic reticulum lumen genetic 1 1 1 Negative Genetic
MAS2 YHR024C Alpha subunit of the mitochondrial processing protease (MPP) genetic 1 1 1 Negative Genetic
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Positive Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
CKI1 YLR133W Choline kinase genetic 1 1 1 Negative Genetic
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Synthetic Rescue
DHR2 YKL078W Predominantly nucleolar DEAH-box ATP-dependent RNA helicase genetic 1 1 1 Synthetic Lethality
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Synthetic Lethality
DSL1 YNL258C Peripheral membrane protein needed for Golgi-to-ER retrograde traffic genetic 1 1 1 Negative Genetic
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis genetic 1 1 1 Synthetic Growth Defect
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Phenotypic Suppression
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
BMT2 YBR141C Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 1 1 1 Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Negative Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Positive Genetic
CET1 YPL228W RNA 5'-triphosphatase involved in mRNA 5' capping genetic 1 1 1 Synthetic Lethality
CDC31 YOR257W Calcium-binding component of the spindle pole body (SPB) half-bridge genetic 1 1 1 Synthetic Lethality
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Positive Genetic
CTK2 YJL006C Beta subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Synthetic Lethality
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 1 1 1 Synthetic Lethality
GCD10 YNL062C Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p genetic 1 1 1 Negative Genetic
ECO1 YFR027W Acetyltransferase required for sister chromatid cohesion genetic 1 1 1 Synthetic Lethality
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 1 1 1 Synthetic Lethality
ERV41 YML067C Protein localized to COPII-coated vesicles genetic 1 1 1 Negative Genetic
CST9 YLR394W SUMO E3 ligase physical 1 1 1 Affinity Capture-Western
JNM1 YMR294W Component of the yeast dynactin complex genetic 1 1 1 Synthetic Lethality
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
MOB1 YIL106W Component of the mitotic exit network genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity genetic 1 1 1 Negative Genetic
EMC5 YIL027C Member of conserved ER transmembrane complex genetic 1 1 1 Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 1 1 1 Synthetic Growth Defect
ENT2 YLR206W Epsin-like protein required for endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
ALG5 YPL227C UDP-glucose:dolichyl-phosphate glucosyltransferase genetic 1 1 1 Negative Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Synthetic Growth Defect
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 1 1 1 Synthetic Growth Defect
CRG1 YHR209W S-AdoMet-dependent methyltransferase involved in lipid homeostasis genetic 1 1 1 Synthetic Growth Defect
MDM1 YML104C PtdIns-3-P binding protein that tethers the ER to vacuoles at NVJs genetic 1 1 1 Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 1 1 1 Negative Genetic
BCH2 YKR027W Member of the ChAPs (Chs5p-Arf1p-binding proteins) family genetic 1 1 1 Negative Genetic
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes physical 1 1 1 Affinity Capture-MS
KTR2 YKR061W Mannosyltransferase involved in N-linked protein glycosylation genetic 1 1 1 Synthetic Growth Defect
HYR1 YIR037W Glutathione peroxidase genetic 1 1 1 Negative Genetic
FCF2 YLR051C Nucleolar protein involved in the early steps of 35S rRNA processing physical 1 1 1 Affinity Capture-MS
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Synthetic Lethality
ACP1 YKL192C Mitochondrial matrix acyl carrier protein genetic 1 1 1 Synthetic Lethality
GRX4 YER174C Glutathione-dependent oxidoreductase and glutathione S-transferase genetic 1 1 1 Negative Genetic
CUL3 YGR003W Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
BYE1 YKL005C Negative regulator of transcription elongation genetic 1 1 1 Negative Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
GVP36 YIL041W BAR domain protein that localizes to early and late Golgi vesicles genetic 1 1 1 Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 1 1 1 Synthetic Lethality
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
DGR2 YKL121W Protein of unknown function genetic 1 1 1 Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 1 1 1 Negative Genetic
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Synthetic Lethality
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
LDB18 YLL049W Component of the dynactin complex genetic 1 1 1 Negative Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
ASP3-4 YLR160C Cell-wall L-asparaginase II involved in asparagine catabolism genetic 1 1 1 Negative Genetic
LYP1 YNL268W Lysine permease genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Synthetic Lethality
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Positive Genetic
DAL2 YIR029W Allantoicase genetic 1 1 1 Positive Genetic
ALG2 YGL065C Mannosyltransferase in the N-linked glycosylation pathway genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
BUD16 YEL029C Putative pyridoxal kinase genetic 1 1 1 Synthetic Growth Defect
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Synthetic Lethality
DSC2 YOL073C Multi-transmembrane subunit of the DSC ubiquitin ligase complex genetic 1 1 1 Negative Genetic
GPI15 YNL038W Protein involved in the synthesis of GlcNAc-PI genetic 1 1 1 Synthetic Lethality
CDC1 YDR182W Putative mannose-ethanolamine phosphate phosphodiesterase genetic 1 1 1 Synthetic Lethality
ERG8 YMR220W Phosphomevalonate kinase genetic 1 1 1 Synthetic Lethality
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
AIM10 YER087W Protein with similarity to tRNA synthetases genetic 1 1 1 Synthetic Growth Defect
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Negative Genetic
MAY24 YPR153W Peripheral ER membrane protein genetic 1 1 1 Negative Genetic