Standard name Systematic name Name description Description
RAD53 YPL153C DNA damage response kinase DNA damage response kinase; signal transduction pathway component required for DNA damage and replication checkpoints, promoting cell cycle arrest and DNA repair; role in initiation of DNA replication; inhibits gene gating through NPC protein phosphorylation, to promote fork stability; activates downstream kinase Dun1p; senses mtDNA depletion and mitochondrial ROS; relocalizes to cytosol under hypoxia; contains two FHA domains; human homolog CHEK2 implicated in breast cancer complements the null
Visualize the interactome of RAD53
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)
G1(P) 38

CYCLoPs localization & abundance

WT1 WT2 WT3
Mito 0.086 0.082 0.081
Nucleus 0.957 0.879 0.850
Cytoplasm NaN 0.053 0.102

GFP localization & abundance

GFP localization GFP abundance
nucleus 6900

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RAD53 5 0 0 2 1

Enzyme information

Catalyzed reactions in Yeast8

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RAD9 YDR217C DNA damage-dependent checkpoint protein physical 27 7 23 Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Two-hybrid, Affinity Capture-Western, Protein-peptide, Protein-peptide, Two-hybrid, Two-hybrid, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Co-purification, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western
ASF1 YJL115W Nucleosome assembly factor physical 24 4 18 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Co-crystal Structure, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
SML1 YML058W Ribonucleotide reductase inhibitor genetic 20 5 20 Phenotypic Enhancement, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Lethality, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex physical 15 5 11 Affinity Capture-Western, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Two-hybrid, Biochemical Activity, Biochemical Activity, Two-hybrid, Reconstituted Complex, Two-hybrid, Co-crystal Structure, Two-hybrid, Reconstituted Complex, Reconstituted Complex
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member physical 12 2 11 Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Affinity Capture-Western, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
HHT2 YNL031C Histone H3 genetic 11 3 8 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Synthetic Rescue, Dosage Growth Defect, Phenotypic Suppression, Dosage Growth Defect, Dosage Growth Defect, Dosage Growth Defect, Phenotypic Suppression
RAD9 YDR217C DNA damage-dependent checkpoint protein genetic 10 4 9 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect
RAD53 YPL153C DNA damage response kinase physical 10 4 7 Biochemical Activity, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Biochemical Activity, Biochemical Activity, Reconstituted Complex, Co-crystal Structure, Biochemical Activity, Biochemical Activity
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase physical 9 5 6 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Reconstituted Complex, Biochemical Activity, Protein-peptide, Biochemical Activity, Affinity Capture-Western, Biochemical Activity
ASF1 YJL115W Nucleosome assembly factor genetic 8 7 7 Synthetic Rescue, Synthetic Growth Defect, Phenotypic Enhancement, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Phenotypic Suppression
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 7 5 7 Synthetic Lethality, Negative Genetic, Synthetic Rescue, Synthetic Lethality, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
EXO1 YOR033C 5'-3' exonuclease and flap-endonuclease genetic 7 3 7 Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue, Phenotypic Enhancement, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
DUN1 YDL101C Cell-cycle checkpoint S/T protein kinase genetic 7 5 6 Dosage Rescue, Synthetic Lethality, Dosage Growth Defect, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Phenotypic Suppression
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex genetic 7 3 6 Phenotypic Suppression, Dosage Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 7 5 5 Synthetic Lethality, Phenotypic Enhancement, Dosage Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Phenotypic Suppression
RRM3 YHR031C DNA helicase involved in rDNA replication and Ty1 transposition genetic 7 5 5 Phenotypic Suppression, Synthetic Growth Defect, Positive Genetic, Negative Genetic, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
CDC45 YLR103C DNA replication initiation factor physical 7 5 2 Two-hybrid, Protein-peptide, Reconstituted Complex, Affinity Capture-Western, Protein-peptide, Biochemical Activity, Two-hybrid
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 6 5 6 Phenotypic Enhancement, Synthetic Lethality, Negative Genetic, Phenotypic Suppression, Synthetic Growth Defect, Negative Genetic
HHF2 YNL030W Histone H4 genetic 6 3 5 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Dosage Growth Defect, Phenotypic Suppression
PTC2 YER089C Type 2C protein phosphatase (PP2C) physical 6 3 5 Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Two-hybrid, Two-hybrid, Protein-peptide
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 6 2 5 Synthetic Rescue, Synthetic Rescue, Synthetic Growth Defect, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) physical 6 5 3 Biochemical Activity, Two-hybrid, Protein-peptide, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-Western
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 5 5 5 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Synthetic Rescue
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Negative Genetic
SLX4 YLR135W Endonuclease involved in processing DNA genetic 5 1 5 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
PDS1 YDR113C Securin genetic 5 3 4 Phenotypic Enhancement, Synthetic Rescue, Synthetic Growth Defect, Synthetic Growth Defect, Phenotypic Enhancement
CDC5 YMR001C Polo-like kinase required for mitotic exit physical 5 2 4 Affinity Capture-Western, Biochemical Activity, Affinity Capture-Western, Affinity Capture-Western, Biochemical Activity
HHT1 YBR010W Histone H3 genetic 5 3 3 Dosage Growth Defect, Dosage Growth Defect, Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
SGS1 YMR190C RecQ family nucleolar DNA helicase physical 5 3 3 Co-localization, Affinity Capture-Western, Two-hybrid, Two-hybrid, Affinity Capture-Western
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes genetic 5 3 3 Dosage Lethality, Synthetic Rescue, Synthetic Rescue, Synthetic Rescue, Phenotypic Enhancement
RAD24 YER173W Checkpoint protein genetic 4 4 4 Phenotypic Enhancement, Negative Genetic, Synthetic Rescue, Phenotypic Suppression
SAE2 YGL175C Endonuclease required for telomere elongation genetic 4 4 4 Dosage Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Phenotypic Suppression
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 4 3 4 Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Synthetic Growth Defect
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Growth Defect
RAD17 YOR368W Checkpoint protein genetic 4 3 4 Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 4 2 4 Dosage Rescue, Negative Genetic, Dosage Rescue, Negative Genetic
RNR1 YER070W Major isoform of large subunit of ribonucleotide-diphosphate reductase genetic 4 2 4 Dosage Rescue, Dosage Rescue, Dosage Growth Defect, Dosage Rescue
PIF1 YML061C DNA helicase, potent G-quadruplex DNA binder/unwinder genetic 4 4 3 Dosage Growth Defect, Synthetic Growth Defect, Phenotypic Suppression, Synthetic Rescue
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 4 3 3 Synthetic Rescue, Phenotypic Suppression, Synthetic Growth Defect, Synthetic Rescue
PRI1 YIR008C Subunit of DNA primase genetic 4 3 3 Negative Genetic, Synthetic Lethality, Phenotypic Suppression, Negative Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 4 2 3 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression, Synthetic Rescue
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation genetic 4 1 3 Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement, Phenotypic Enhancement
LSM1 YJL124C Lsm (Like Sm) protein genetic 3 3 3 Synthetic Lethality, Negative Genetic, Phenotypic Enhancement
CHK1 YBR274W Serine/threonine kinase and DNA damage checkpoint effector genetic 3 3 3 Phenotypic Enhancement, Positive Genetic, Phenotypic Suppression
TSA1 YML028W Thioredoxin peroxidase genetic 3 3 3 Dosage Rescue, Synthetic Growth Defect, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 3 2 3 Phenotypic Enhancement, Synthetic Rescue, Phenotypic Enhancement
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Positive Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
SWI6 YLR182W Transcription cofactor physical 3 2 3 Biochemical Activity, Biochemical Activity, Affinity Capture-MS
SAC3 YDR159W mRNA export factor genetic 3 2 3 Synthetic Rescue, Negative Genetic, Synthetic Rescue
HPC2 YBR215W Subunit of the HIR complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 3 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SLD3 YGL113W Protein involved in the initiation of DNA replication physical 3 1 3 Biochemical Activity, Biochemical Activity, Biochemical Activity
REV3 YPL167C Catalytic subunit of DNA polymerase zeta genetic 3 1 3 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect
SIR4 YDR227W SIR protein involved in assembly of silent chromatin domains genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
SIR3 YLR442C Silencing protein genetic 3 1 3 Synthetic Rescue, Synthetic Rescue, Synthetic Rescue
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 3 1 3 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality
CDC10 YCR002C Component of the septin ring, required for cytokinesis physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
CDC11 YJR076C Component of the septin ring that is required for cytokinesis physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
SHS1 YDL225W Component of the septin ring that is required for cytokinesis physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
RAD55 YDR076W Protein that stimulates strand exchange physical 3 2 2 Biochemical Activity, Two-hybrid, Biochemical Activity
RTT109 YLL002W Histone acetyltransferase genetic 3 2 2 Phenotypic Suppression, Phenotypic Suppression, Negative Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 3 2 2 Synthetic Lethality, Synthetic Lethality, Negative Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western
IES4 YOR189W Component of the INO80 chromatiin remodeling complex physical 3 3 1 Protein-peptide, Reconstituted Complex, Affinity Capture-Western
FKH1 YIL131C Forkhead family transcription factor regulation 2 2 2 chromatin immunoprecipitation-chip evidence, ChEC-Seq experiments
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
BMH1 YER177W 14-3-3 protein, major isoform genetic 2 2 2 Dosage Rescue, Synthetic Rescue
PUS7 YOR243C Pseudouridine synthase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HPR1 YDR138W Subunit of THO/TREX complexes genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
DNA2 YHR164C ATP-dependent 5'-flap endonuclease and DNA helicase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
BDF2 YDL070W Protein involved in transcription initiation genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 2 2 2 Synthetic Rescue, Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 2 2 2 Dosage Lethality, Synthetic Lethality
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HEL2 YDR266C RING finger ubiquitin ligase (E3) physical 2 2 2 Biochemical Activity, Affinity Capture-Western
IRA2 YOL081W GTPase-activating protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HTB1 YDR224C Histone H2B genetic 2 2 2 Synthetic Rescue, Synthetic Growth Defect
HIR3 YJR140C Subunit of the HIR complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BFA1 YJR053W Subunit of a two-component GTPase-activating protein, Bfa1p-Bub2p genetic 2 2 2 Negative Genetic, Phenotypic Suppression
KAP122 YGL016W Karyopherin beta genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
RAD14 YMR201C Subunit of Nucleotide Excision Repair Factor 1 (NEF1) genetic 2 2 2 Phenotypic Enhancement, Synthetic Growth Defect
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
THP1 YOL072W Nuclear pore-associated protein genetic 2 2 2 Negative Genetic, Synthetic Rescue
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 2 2 Negative Genetic, Synthetic Rescue
RLF2 YPR018W Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1) genetic 2 2 2 Phenotypic Enhancement, Synthetic Rescue
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 2 2 2 Negative Genetic, Synthetic Lethality
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
RTT101 YJL047C Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex genetic 2 2 2 Phenotypic Suppression, Positive Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
YBL081W YBL081W Non-essential protein of unknown function genetic 2 2 2 Synthetic Lethality, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 2 2 2 Synthetic Lethality, Negative Genetic
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 2 2 2 Negative Genetic, Phenotypic Suppression
SWE1 YJL187C Protein kinase that regulates the G2/M transition genetic 2 2 2 Phenotypic Enhancement, Phenotypic Suppression
RPH1 YER169W JmjC domain-containing histone demethylase genetic 2 2 2 Phenotypic Suppression, Synthetic Rescue
LOS1 YKL205W Nuclear pore protein genetic 2 2 2 Synthetic Rescue, Phenotypic Suppression
MMS4 YBR098W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 2 2 2 Synthetic Growth Defect, Phenotypic Suppression
CSM1 YCR086W Nucleolar protein that mediates homolog segregation during meiosis I genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
GDS1 YOR355W Protein involved in histone H4 acetylation at ribosomal protein genes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CSM3 YMR048W Replication fork associated factor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 2 2 Negative Genetic, Synthetic Lethality
RAD5 YLR032W DNA helicase/Ubiquitin ligase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 2 2 2 Synthetic Growth Defect, Dosage Growth Defect
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
PUF4 YGL014W Member of the PUF protein family genetic 2 2 2 Synthetic Lethality, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 2 2 2 Synthetic Lethality, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 2 2 2 Synthetic Rescue, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 2 1 2 Negative Genetic, Negative Genetic
PSY2 YNL201C Subunit of protein phosphatase PP4 complex physical 2 1 2 Two-hybrid, Two-hybrid
KAP95 YLR347C Karyopherin beta physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC12 YHR107C Component of the septin ring that is required for cytokinesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CDC3 YLR314C Component of the septin ring that is required for cytokinesis physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) genetic 2 1 2 Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
LSM7 YNL147W Lsm (Like Sm) protein genetic 2 1 2 Negative Genetic, Negative Genetic
BUD3 YCL014W Guanine nucleotide exchange factor (GEF) for Cdc42p physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PPH3 YDR075W Catalytic subunit of protein phosphatase PP4 complex physical 2 1 2 Biochemical Activity, Biochemical Activity
MCM2 YBL023C Protein involved in DNA replication genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
CDC9 YDL164C DNA ligase I found in nucleus and mitochondria genetic 2 1 2 Phenotypic Suppression, Phenotypic Suppression
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
HHT1 YBR010W Histone H3 physical 2 1 2 Affinity Capture-Western, Affinity Capture-Western
DPB11 YJL090C DNA replication initiation protein genetic 2 1 2 Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 2 1 2 Synthetic Rescue, Synthetic Rescue
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 2 1 2 Dosage Rescue, Dosage Rescue
SRP1 YNL189W Karyopherin alpha homolog physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TBF1 YPL128C Telobox-containing general regulatory factor physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RCK2 YLR248W Protein kinase involved in response to oxidative and osmotic stress physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
SNU66 YOR308C Component of the U4/U6.U5 snRNP complex genetic 2 1 2 Negative Genetic, Negative Genetic
RFA1 YAR007C Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 1 2 Negative Genetic, Negative Genetic
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 2 1 2 Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 2 1 2 Negative Genetic, Negative Genetic
APN1 YKL114C Major apurinic/apyrimidinic endonuclease genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
BUD4 YJR092W Anillin-like protein involved in bud-site selection physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 2 Negative Genetic, Negative Genetic
CLA4 YNL298W Cdc42p-activated signal transducing kinase physical 2 1 2 Biochemical Activity, Biochemical Activity
ORC6 YHR118C Subunit of the origin recognition complex (ORC) genetic 2 1 2 Synthetic Lethality, Synthetic Lethality
ERG3 YLR056W C-5 sterol desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
CDC45 YLR103C DNA replication initiation factor regulation 2 2 1 protein kinase assay evidence, qualitative western immunoblotting evidence
HSP82 YPL240C Hsp90 chaperone genetic 2 2 1 Phenotypic Suppression, Dosage Rescue
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage physical 2 2 1 Two-hybrid, Affinity Capture-Western
CDC37 YDR168W Essential Hsp90p co-chaperone genetic 2 2 1 Positive Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase physical 2 2 1 Two-hybrid, Biochemical Activity
SAE2 YGL175C Endonuclease required for telomere elongation physical 2 2 1 Affinity Capture-MS, Protein-peptide
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes physical 2 2 1 Biochemical Activity, Affinity Capture-Western
YCR090C YCR090C Putative protein of unknown function genetic 2 2 1 Positive Genetic, Negative Genetic
RPL6B YLR448W Ribosomal 60S subunit protein L6B genetic 2 2 1 Positive Genetic, Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
SPP1 YPL138C Subunit of COMPASS (Set1C) genetic 2 2 1 Synthetic Rescue, Phenotypic Suppression
DOT1 YDR440W Nucleosomal histone H3-Lys79 methylase genetic 2 2 1 Synthetic Growth Defect, Dosage Growth Defect
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 2 2 1 Synthetic Rescue, Phenotypic Enhancement
PMS1 YNL082W ATP-binding protein required for mismatch repair genetic 2 2 1 Positive Genetic, Negative Genetic
ISC1 YER019W Inositol phosphosphingolipid phospholipase C genetic 2 2 1 Dosage Rescue, Phenotypic Suppression
ELG1 YOR144C Subunit of an alternative replication factor C complex physical 2 1 1 Affinity Capture-Western, Affinity Capture-Western
MED2 YDL005C Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MBP1 YDL056W Transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
ARO9 YHR137W Aromatic aminotransferase II regulation 1 1 1 protein kinase assay evidence
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity regulation 1 1 1 protein kinase assay evidence
YAP1 YML007W Basic leucine zipper (bZIP) transcription factor regulation 1 1 1 protein kinase assay evidence
TUB2 YFL037W Beta-tubulin regulation 1 1 1 protein kinase assay evidence
SRV2 YNL138W CAP (cyclase-associated protein) regulation 1 1 1 protein kinase assay evidence
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression regulation 1 1 1 protein kinase assay evidence
MPP10 YJR002W Component of the SSU processome and 90S preribosome regulation 1 1 1 protein kinase assay evidence
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex regulation 1 1 1 protein kinase assay evidence
NET1 YJL076W Core subunit of the RENT complex regulation 1 1 1 protein kinase assay evidence
CRN1 YLR429W Coronin regulation 1 1 1 protein kinase assay evidence
GLE1 YDL207W Cytoplasmic nucleoporin required for polyadenylated mRNA export regulation 1 1 1 protein kinase assay evidence
SET3 YKR029C Defining member of the SET3 histone deacetylase complex regulation 1 1 1 protein kinase assay evidence
ECM32 YER176W DNA dependent ATPase/DNA helicase regulation 1 1 1 protein kinase assay evidence
RPG1 YBR079C eIF3a subunit of the eukaryotic translation initiation factor 3 (eIF3) regulation 1 1 1 protein kinase assay evidence
LAS1 YKR063C Endonuclease involved in pre-rRNA processing at both ends of ITS2 regulation 1 1 1 protein kinase assay evidence
NOP56 YLR197W Essential evolutionarily-conserved nucleolar protein regulation 1 1 1 protein kinase assay evidence
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome regulation 1 1 1 protein kinase assay evidence
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway regulation 1 1 1 protein kinase assay evidence
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease regulation 1 1 1 protein kinase assay evidence
NSP1 YJL041W FG-nucleoporin component of central core of the nuclear pore complex regulation 1 1 1 protein kinase assay evidence
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex regulation 1 1 1 protein kinase assay evidence
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex regulation 1 1 1 protein kinase assay evidence
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 regulation 1 1 1 protein kinase assay evidence
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin regulation 1 1 1 protein kinase assay evidence
SKI7 YOR076C GTP-binding protein that couples the Ski complex and exosome regulation 1 1 1 protein kinase assay evidence
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors regulation 1 1 1 protein kinase assay evidence
HXT2 YMR011W High-affinity glucose transporter of the major facilitator superfamily regulation 1 1 1 protein kinase assay evidence
HST1 YOL068C NAD(+)-dependent histone deacetylase regulation 1 1 1 protein kinase assay evidence
NOP12 YOL041C Nucleolar protein involved in pre-25S rRNA processing regulation 1 1 1 protein kinase assay evidence
RLP7 YNL002C Nucleolar protein similar to large ribosomal subunit L7 proteins regulation 1 1 1 protein kinase assay evidence
NSR1 YGR159C Nucleolin, nucleolar protein that binds nuclear localization sequences regulation 1 1 1 protein kinase assay evidence
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport regulation 1 1 1 protein kinase assay evidence
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p regulation 1 1 1 protein kinase assay evidence
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase regulation 1 1 1 protein kinase assay evidence
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) regulation 1 1 1 protein kinase assay evidence
PGM2 YMR105C Phosphoglucomutase regulation 1 1 1 protein kinase assay evidence
SEC53 YFL045C Phosphomannomutase regulation 1 1 1 protein kinase assay evidence
PAB1 YER165W Poly(A) binding protein regulation 1 1 1 protein kinase assay evidence
ENP1 YBR247C Protein associated with U3 and U14 snoRNAs regulation 1 1 1 protein kinase assay evidence
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit regulation 1 1 1 protein kinase assay evidence
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage regulation 1 1 1 protein kinase assay evidence
SLD3 YGL113W Protein involved in the initiation of DNA replication regulation 1 1 1 protein kinase assay evidence
RBA50 YDR527W Protein involved in transcription regulation 1 1 1 protein kinase assay evidence
YLR257W YLR257W Protein of unknown function regulation 1 1 1 protein kinase assay evidence
PRP45 YAL032C Protein required for pre-mRNA splicing regulation 1 1 1 protein kinase assay evidence
INH1 YDL181W Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase regulation 1 1 1 protein kinase assay evidence
NPL3 YDR432W RNA-binding protein regulation 1 1 1 protein kinase assay evidence
DEF1 YKL054C RNAPII degradation factor regulation 1 1 1 protein kinase assay evidence
ALB1 YJL122W Shuttling pre-60S factor regulation 1 1 1 protein kinase assay evidence
HSP42 YDR171W Small heat shock protein (sHSP) with chaperone activity regulation 1 1 1 protein kinase assay evidence
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity regulation 1 1 1 protein kinase assay evidence
PUS1 YPL212C tRNA:pseudouridine synthase regulation 1 1 1 protein kinase assay evidence
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) regulation 1 1 1 protein kinase assay evidence
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions regulation 1 1 1 protein kinase assay evidence
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member regulation 1 1 1 qualitative western immunoblotting evidence
TEL1 YBL088C Protein kinase primarily involved in telomere length regulation regulation 1 1 1 qualitative western immunoblotting evidence
CDC73 YLR418C Component of the Paf1p complex genetic 1 1 1 Synthetic Lethality
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Negative Genetic
PSF1 YDR013W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
PSF2 YJL072C Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) physical 1 1 1 Affinity Capture-MS
MMS21 YEL019C Highly conserved SUMO E3 ligase subunit of SMC5-SMC6 complex genetic 1 1 1 Phenotypic Suppression
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Lethality
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
NSE5 YML023C Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
BRE1 YDL074C E3 ubiquitin ligase genetic 1 1 1 Synthetic Rescue
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Positive Genetic
FRT2 YAL028W Tail-anchored ER membrane protein of unknown function physical 1 1 1 Biochemical Activity
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases physical 1 1 1 Biochemical Activity
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) physical 1 1 1 Biochemical Activity
ALB1 YJL122W Shuttling pre-60S factor physical 1 1 1 Biochemical Activity
LSM6 YDR378C Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
PRP3 YDR473C Splicing factor genetic 1 1 1 Negative Genetic
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Biochemical Activity
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Lethality
PSY2 YNL201C Subunit of protein phosphatase PP4 complex genetic 1 1 1 Dosage Growth Defect
MFT1 YML062C Subunit of the THO complex genetic 1 1 1 Synthetic Rescue
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Biochemical Activity
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 1 1 1 Negative Genetic
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Lethality
ECM16 YMR128W Essential DEAH-box ATP-dependent RNA helicase specific to U3 snoRNP physical 1 1 1 Affinity Capture-MS
PUS1 YPL212C tRNA:pseudouridine synthase physical 1 1 1 Biochemical Activity
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Synthetic Growth Defect
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-Western
BMH2 YDR099W 14-3-3 protein, minor isoform genetic 1 1 1 Dosage Rescue
BUD14 YAR014C Protein involved in bud-site selection physical 1 1 1 Affinity Capture-MS
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Growth Defect
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Positive Genetic
CDC45 YLR103C DNA replication initiation factor genetic 1 1 1 Negative Genetic
BUD31 YCR063W Component of the SF3b subcomplex of the U2 snRNP genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Synthetic Growth Defect
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 1 1 1 Negative Genetic
CIA2 YHR122W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Synthetic Lethality
DPB3 YBR278W Third-largest subunit of DNA polymerase II (DNA polymerase epsilon) physical 1 1 1 Biochemical Activity
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites physical 1 1 1 Affinity Capture-MS
EAF3 YPR023C Component of the Rpd3S histone deacetylase complex genetic 1 1 1 Synthetic Growth Defect
EXO84 YBR102C Exocyst subunit with dual roles in exocytosis and spliceosome assembly genetic 1 1 1 Negative Genetic
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 1 1 1 Biochemical Activity
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Dosage Growth Defect
HHF1 YBR009C Histone H4 genetic 1 1 1 Synthetic Rescue
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator genetic 1 1 1 Synthetic Growth Defect
HHF2 YNL030W Histone H4 physical 1 1 1 Affinity Capture-Western
HST1 YOL068C NAD(+)-dependent histone deacetylase physical 1 1 1 Biochemical Activity
DPB4 YDR121W Subunit of DNA pol epsilon and of ISW2 chromatin accessibility complex physical 1 1 1 Biochemical Activity
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 1 1 1 Affinity Capture-MS
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers physical 1 1 1 Affinity Capture-RNA
ISW2 YOR304W ATP-dependent DNA translocase involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
END3 YNL084C EH domain-containing protein involved in endocytosis physical 1 1 1 Two-hybrid
LAS17 YOR181W Actin assembly factor physical 1 1 1 Biochemical Activity
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM2 YBL026W Lsm (Like Sm) protein genetic 1 1 1 Negative Genetic
MAL12 YGR292W Maltase (alpha-D-glucosidase) genetic 1 1 1 Negative Genetic
MBP1 YDL056W Transcription factor physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex physical 1 1 1 Affinity Capture-MS
MCM5 YLR274W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Phenotypic Suppression
CMR1 YDL156W Nuclear protein with role in transcription, protein quality control genetic 1 1 1 Synthetic Growth Defect
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring physical 1 1 1 Affinity Capture-MS
GIN4 YDR507C Protein kinase involved in bud growth and assembly of the septin ring genetic 1 1 1 Synthetic Growth Defect
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Lethality
NCL1 YBL024W S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase physical 1 1 1 Biochemical Activity
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Synthetic Growth Defect
NHP10 YDL002C Non-essential INO80 chromatin remodeling complex subunit genetic 1 1 1 Synthetic Growth Defect
NUP60 YAR002W FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Biochemical Activity
ORC1 YML065W Largest subunit of the origin recognition complex genetic 1 1 1 Synthetic Growth Defect
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member physical 1 1 1 Affinity Capture-MS
MGS1 YNL218W Protein with DNA-dependent ATPase and ssDNA annealing activities genetic 1 1 1 Dosage Lethality
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Lethality
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
POP2 YNR052C Subunit of Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation genetic 1 1 1 Synthetic Lethality
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
HTA1 YDR225W Histone H2A genetic 1 1 1 Synthetic Growth Defect
PRP31 YGR091W Splicing factor genetic 1 1 1 Negative Genetic
PRP6 YBR055C Splicing factor genetic 1 1 1 Negative Genetic
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Positive Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 1 1 1 Positive Genetic
PAA1 YDR071C Polyamine acetyltransferase physical 1 1 1 Affinity Capture-MS
PAA1 YDR071C Polyamine acetyltransferase genetic 1 1 1 Synthetic Growth Defect
NRP1 YDL167C Putative RNA binding protein of unknown function genetic 1 1 1 Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon physical 1 1 1 Biochemical Activity
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Synthetic Rescue
BUD21 YOR078W Component of small ribosomal subunit (SSU) processosome genetic 1 1 1 Negative Genetic
HTA2 YBL003C Histone H2A physical 1 1 1 Affinity Capture-MS
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 1 1 1 Synthetic Growth Defect
MKT1 YNL085W Protein similar to nucleases that forms a complex with Pbp1p genetic 1 1 1 Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 1 1 1 Synthetic Growth Defect
FYV8 YGR196C Protein of unknown function physical 1 1 1 Affinity Capture-MS
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Biochemical Activity
NUM1 YDR150W Protein required for nuclear migration physical 1 1 1 Affinity Capture-MS
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 1 1 1 Negative Genetic
OSH2 YDL019C Member of an oxysterol-binding protein family with seven members physical 1 1 1 Biochemical Activity
NUP85 YJR042W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
NET1 YJL076W Core subunit of the RENT complex physical 1 1 1 Affinity Capture-MS
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
PRP11 YDL043C Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 1 1 1 Synthetic Lethality
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Synthetic Rescue
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 1 1 1 Synthetic Growth Defect
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Lethality
RAD1 YPL022W Single-stranded DNA endonuclease (with Rad10p) genetic 1 1 1 Synthetic Lethality
RAD10 YML095C Single-stranded DNA endonuclease (with Rad1p) genetic 1 1 1 Synthetic Growth Defect
PUF3 YLL013C Protein of the mitochondrial outer surface physical 1 1 1 Affinity Capture-RNA
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails physical 1 1 1 Affinity Capture-MS
MDH1 YKL085W Mitochondrial malate dehydrogenase physical 1 1 1 Affinity Capture-MS
PYC2 YBR218C Pyruvate carboxylase isoform genetic 1 1 1 Positive Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Synthetic Rescue
CDC5 YMR001C Polo-like kinase required for mitotic exit genetic 1 1 1 Phenotypic Suppression
DMA2 YNL116W Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-Western
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Phenotypic Suppression
AHP1 YLR109W Thiol-specific peroxiredoxin genetic 1 1 1 Negative Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway physical 1 1 1 Biochemical Activity
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Synthetic Growth Defect
GET1 YGL020C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
GET2 YER083C Subunit of the GET complex genetic 1 1 1 Synthetic Growth Defect
ADK1 YDR226W Adenylate kinase, required for purine metabolism physical 1 1 1 Biochemical Activity
CYC8 YBR112C General transcriptional co-repressor genetic 1 1 1 Dosage Rescue
DDC1 YPL194W DNA damage checkpoint protein physical 1 1 1 Biochemical Activity
DDC1 YPL194W DNA damage checkpoint protein genetic 1 1 1 Synthetic Growth Defect
INM1 YHR046C Inositol monophosphatase genetic 1 1 1 Negative Genetic
DMC1 YER179W Meiosis-specific recombinase required for double-strand break repair genetic 1 1 1 Phenotypic Suppression
DOP1 YDR141C Protein involved in vesicular transport at trans-Golgi network (TGN) genetic 1 1 1 Negative Genetic
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Negative Genetic
DMA1 YHR115C Ubiquitin-protein ligase (E3) physical 1 1 1 Affinity Capture-Western
ELM1 YKL048C Serine/threonine protein kinase genetic 1 1 1 Synthetic Growth Defect
DAS1 YJL149W Putative SCF ubiquitin ligase F-box protein genetic 1 1 1 Negative Genetic
GID8 YMR135C Subunit of GID Complex, binds strongly to central component Vid30p physical 1 1 1 Affinity Capture-MS
PBA1 YLR199C Protein involved in 20S proteasome assembly genetic 1 1 1 Synthetic Rescue
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Synthetic Rescue
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Synthetic Rescue
CAC2 YML102W Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p genetic 1 1 1 Phenotypic Enhancement
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation physical 1 1 1 Biochemical Activity
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Synthetic Growth Defect
IRA1 YBR140C GTPase-activating protein genetic 1 1 1 Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 1 1 1 Synthetic Growth Defect
BCK2 YER167W Serine/threonine-rich protein involved in PKC1 signaling pathway genetic 1 1 1 Positive Genetic
NTG1 YAL015C DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase genetic 1 1 1 Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 1 1 1 Synthetic Lethality
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport physical 1 1 1 Biochemical Activity
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex physical 1 1 1 Biochemical Activity
NUP1 YOR098C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Synthetic Rescue
PTC2 YER089C Type 2C protein phosphatase (PP2C) genetic 1 1 1 Dosage Lethality
YTA7 YGR270W Chromatin-binding ATPase that regulates histone gene expression genetic 1 1 1 Negative Genetic
UTP22 YGR090W Component of the small-subunit processome physical 1 1 1 Affinity Capture-MS
SMC3 YJL074C Subunit of the multiprotein cohesin complex physical 1 1 1 Affinity Capture-MS
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 1 1 1 Dosage Lethality
VHR2 YER064C Non-essential nuclear protein physical 1 1 1 Biochemical Activity
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Biochemical Activity
SLA1 YBL007C Cytoskeletal protein binding protein physical 1 1 1 Biochemical Activity
UBP9 YER098W Ubiquitin-specific protease that cleaves ubiquitin-protein fusions physical 1 1 1 Biochemical Activity
UBP10 YNL186W Ubiquitin-specific protease, deubiquitinates Ub-protein moieties physical 1 1 1 Biochemical Activity
YNL284C-A YNL284C-A Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Biochemical Activity
YGR210C YGR210C Putative protein of unknown function physical 1 1 1 Biochemical Activity
YDR034C-C YDR034C-C Retrotransposon TYA Gag gene co-transcribed with TYB Pol physical 1 1 1 Biochemical Activity
SHE3 YBR130C Protein adaptor between Myo4p and the She2p-mRNA complex physical 1 1 1 Biochemical Activity
SSD1 YDR293C Translational repressor physical 1 1 1 Biochemical Activity
YLR257W YLR257W Protein of unknown function physical 1 1 1 Biochemical Activity
YPL150W YPL150W Protein kinase of unknown cellular role physical 1 1 1 Biochemical Activity
VHS2 YIL135C Regulator of septin dynamics physical 1 1 1 Biochemical Activity
SAS10 YDL153C Subunit of U3-containing Small Subunit (SSU) processome complex physical 1 1 1 Biochemical Activity
RNH70 YGR276C 3'-5' exoribonuclease physical 1 1 1 Biochemical Activity
WHI5 YOR083W Repressor of G1 transcription physical 1 1 1 Affinity Capture-MS
SRC1 YML034W Inner nuclear membrane protein physical 1 1 1 Affinity Capture-MS
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p physical 1 1 1 Affinity Capture-MS
RAD55 YDR076W Protein that stimulates strand exchange genetic 1 1 1 Phenotypic Suppression
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Affinity Capture-Western
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Affinity Capture-Western
SML1 YML058W Ribonucleotide reductase inhibitor physical 1 1 1 Affinity Capture-Western
VID22 YLR373C G-quadruplex (G4) DNA binding protein physical 1 1 1 Affinity Capture-MS
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
YGR130C YGR130C Component of the eisosome with unknown function physical 1 1 1 Affinity Capture-MS
ROG3 YFR022W Alpha-arrestin involved in ubiquitin-dependent endocytosis physical 1 1 1 Two-hybrid
SNU71 YGR013W Component of U1 snRNP required for mRNA splicing via spliceosome physical 1 1 1 Two-hybrid
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II physical 1 1 1 Two-hybrid
YAP7 YOL028C Transcriptional repressor of nitric oxide oxidase physical 1 1 1 Two-hybrid
SMN1 YHR202W Putative AMP hydrolase physical 1 1 1 Two-hybrid
YPK1 YKL126W S/T protein kinase physical 1 1 1 Reconstituted Complex
SLD3 YGL113W Protein involved in the initiation of DNA replication genetic 1 1 1 Negative Genetic
SNT2 YGL131C Subunit of Snt2C complex, RING finger ubiquitin ligase (E3) physical 1 1 1 Affinity Capture-Western
STE20 YHL007C Cdc42p-activated signal transducing kinase physical 1 1 1 Biochemical Activity
UBC5 YDR059C Ubiquitin-conjugating enzyme physical 1 1 1 Affinity Capture-Western
THP1 YOL072W Nuclear pore-associated protein physical 1 1 1 Affinity Capture-MS
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease physical 1 1 1 Biochemical Activity
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Biochemical Activity
SRV2 YNL138W CAP (cyclase-associated protein) physical 1 1 1 Biochemical Activity
SET3 YKR029C Defining member of the SET3 histone deacetylase complex physical 1 1 1 Biochemical Activity
SNU23 YDL098C Component of the U4/U6.U5 snRNP complex physical 1 1 1 Biochemical Activity
SCP160 YJL080C Essential RNA-binding G protein effector of mating response pathway physical 1 1 1 Biochemical Activity
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Dosage Rescue
ZRG8 YER033C Protein of unknown function genetic 1 1 1 Dosage Rescue
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit genetic 1 1 1 Synthetic Lethality
RMI1 YPL024W Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex genetic 1 1 1 Synthetic Lethality
SPT4 YGR063C Spt4p/5p (DSIF) transcription elongation factor complex subunit genetic 1 1 1 Negative Genetic
WTM2 YOR229W Transcriptional modulator genetic 1 1 1 Dosage Rescue
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 1 1 1 Synthetic Rescue
RNR3 YIL066C Minor isoform of large subunit of ribonucleotide-diphosphate reductase genetic 1 1 1 Dosage Rescue
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Dosage Rescue
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 1 1 1 Dosage Rescue
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 1 1 1 Dosage Rescue
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) genetic 1 1 1 Dosage Rescue
SRL3 YKR091W Repressor of transcription at Start genetic 1 1 1 Dosage Rescue
SRL1 YOR247W Mannoprotein that exhibits a tight association with the cell wall genetic 1 1 1 Dosage Rescue
TAF14 YPL129W Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes genetic 1 1 1 Dosage Rescue
SWI1 YPL016W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
THR1 YHR025W Homoserine kinase genetic 1 1 1 Positive Genetic
REG1 YDR028C Regulatory subunit of type 1 protein phosphatase Glc7p genetic 1 1 1 Positive Genetic
RAT1 YOR048C Nuclear 5' to 3' single-stranded RNA exonuclease genetic 1 1 1 Synthetic Growth Defect
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Synthetic Growth Defect
SPT6 YGR116W Nucleosome remodeling protein genetic 1 1 1 Synthetic Growth Defect
RMD8 YFR048W Cytosolic protein required for sporulation genetic 1 1 1 Synthetic Growth Defect
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Growth Defect
YGR122W YGR122W Protein that may be involved in pH regulation genetic 1 1 1 Synthetic Growth Defect
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Synthetic Growth Defect
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 1 1 1 Synthetic Growth Defect
VPS5 YOR069W Nexin-1 homolog genetic 1 1 1 Synthetic Growth Defect
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Synthetic Growth Defect
WHI3 YNL197C RNA binding protein that modulates mRNA stability genetic 1 1 1 Synthetic Growth Defect
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Lethality
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Lethality
VPS34 YLR240W Phosphatidylinositol (PI) 3-kinase that synthesizes PI-3-phosphate genetic 1 1 1 Synthetic Lethality
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Synthetic Growth Defect
YPT6 YLR262C Rab family GTPase genetic 1 1 1 Synthetic Growth Defect
SMC6 YLR383W Subunit of the SMC5-SMC6 complex genetic 1 1 1 Phenotypic Enhancement
SUS1 YBR111W-A Global transcriptional regulator, component of SAGA, TREX-2 complexes genetic 1 1 1 Synthetic Rescue
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Synthetic Rescue
THO2 YNL139C Subunit of the THO complex genetic 1 1 1 Synthetic Rescue
RDH54 YBR073W DNA-dependent ATPase genetic 1 1 1 Phenotypic Suppression
SLD7 YOR060C Protein with a role in chromosomal DNA replication genetic 1 1 1 Synthetic Lethality
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 1 1 1 Synthetic Lethality
RNA15 YGL044C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Synthetic Lethality
TPP1 YMR156C DNA 3'-phosphatase genetic 1 1 1 Synthetic Lethality
REV1 YOR346W Deoxycytidyl transferase genetic 1 1 1 Synthetic Growth Defect
REV7 YIL139C Accessory subunit of DNA polymerase zeta genetic 1 1 1 Synthetic Growth Defect
RNH203 YLR154C Ribonuclease H2 subunit genetic 1 1 1 Synthetic Growth Defect
RTT106 YNL206C Histone chaperone genetic 1 1 1 Synthetic Growth Defect
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Phenotypic Suppression
SPO11 YHL022C Meiosis-specific protein required for meiotic recombination genetic 1 1 1 Phenotypic Suppression
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 1 1 1 Phenotypic Suppression
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Positive Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 1 1 1 Positive Genetic
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Positive Genetic
YJR120W YJR120W Protein of unknown function genetic 1 1 1 Positive Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 1 1 1 Positive Genetic
RPS1A YLR441C Ribosomal protein of the small (40S) subunit genetic 1 1 1 Positive Genetic
RGA1 YOR127W GTPase-activating protein for polarity-regulator Cdc42p (RhoGAP) genetic 1 1 1 Positive Genetic
SHG1 YBR258C Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Positive Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TAF12 YDR145W Subunit (61/68 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TCP1 YDR212W Alpha subunit of chaperonin-containing T-complex genetic 1 1 1 Negative Genetic
SLD5 YDR489W Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p) genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Negative Genetic
TAF6 YGL112C Subunit (60 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
SMD1 YGR074W Core Sm protein Sm D1 genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
SNU114 YKL173W GTPase component of U5 snRNP involved in mRNA splicing via spliceosome genetic 1 1 1 Negative Genetic
TAF11 YML015C TFIID subunit (40 kDa) genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
TAF4 YMR005W TFIID subunit (48 kDa) genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
RFC4 YOL094C Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
SGT1 YOR057W Cochaperone protein genetic 1 1 1 Negative Genetic
TOA1 YOR194C TFIIA large subunit genetic 1 1 1 Negative Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Negative Genetic
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
SSS1 YDR086C Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Negative Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
SEC22 YLR268W R-SNARE protein genetic 1 1 1 Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 1 1 1 Negative Genetic
URA7 YBL039C Major CTP synthase isozyme (see also URA8) genetic 1 1 1 Negative Genetic
SSA3 YBL075C ATPase involved in protein folding and the response to stress genetic 1 1 1 Negative Genetic
RCR1 YBR005W Plasma membrane (PM) ubiquitin ligase-substrate adaptor genetic 1 1 1 Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
RRT2 YBR246W Methylesterase performing penultimate step of diphthamide biosynthesis genetic 1 1 1 Negative Genetic
SPO23 YBR250W Protein of unknown function genetic 1 1 1 Negative Genetic
YDL086W YDL086W Putative carboxymethylenebutenolidase genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
RRT13 YER066W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBP2 YGL060W Central kinetochore associated protein genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 1 1 1 Negative Genetic
YGL235W YGL235W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
TOS2 YGR221C Protein involved in localization of Cdc24p to the site of bud growth genetic 1 1 1 Negative Genetic
RCI37 YIL077C Protein that associates with the large mitoribosomal subunit genetic 1 1 1 Negative Genetic
SYS1 YJL004C Integral membrane protein of the Golgi genetic 1 1 1 Negative Genetic
SNX4 YJL036W Sorting nexin genetic 1 1 1 Negative Genetic
YHC3 YJL059W Protein required for the ATP-dependent transport of arginine genetic 1 1 1 Negative Genetic
TMA22 YJR014W Protein of unknown function genetic 1 1 1 Negative Genetic
RPL14A YKL006W Ribosomal 60S subunit protein L14A genetic 1 1 1 Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 1 1 1 Negative Genetic
TOF2 YKR010C Protein required for rDNA silencing and mitotic rDNA condensation genetic 1 1 1 Negative Genetic
RQT4 YKR023W Subunit of ribosome-associated quality control trigger complex (RQT) genetic 1 1 1 Negative Genetic
VBA5 YKR105C Plasma membrane protein of the Major Facilitator Superfamily (MFS) genetic 1 1 1 Negative Genetic
RPL8B YLL045C Ribosomal 60S subunit protein L8A genetic 1 1 1 Negative Genetic
YLR053C YLR053C Putative protein of unknown function genetic 1 1 1 Negative Genetic
TOP3 YLR234W DNA Topoisomerase III genetic 1 1 1 Negative Genetic
REH1 YLR387C Cytoplasmic 60S subunit biogenesis factor genetic 1 1 1 Negative Genetic
STE23 YLR389C Metalloprotease genetic 1 1 1 Negative Genetic
TDA5 YLR426W Putative protein of unknown function genetic 1 1 1 Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 1 1 1 Negative Genetic
YML108W YML108W Protein of unknown function genetic 1 1 1 Negative Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 1 1 1 Negative Genetic
TDA1 YMR291W Protein kinase of unknown cellular role genetic 1 1 1 Negative Genetic
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Negative Genetic
SMM1 YNR015W Dihydrouridine synthase genetic 1 1 1 Negative Genetic
SFL1 YOR140W Transcriptional repressor and activator genetic 1 1 1 Negative Genetic
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
YBR238C YBR238C Mitochondrial membrane protein genetic 1 1 1 Negative Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Negative Genetic
RPL13A YDL082W Ribosomal 60S subunit protein L13A genetic 1 1 1 Negative Genetic
YGR050C YGR050C Protein of unknown function genetic 1 1 1 Negative Genetic
YGR237C YGR237C Putative protein of unknown function genetic 1 1 1 Negative Genetic
SET2 YJL168C Histone methyltransferase with a role in transcriptional elongation genetic 1 1 1 Negative Genetic
YLR278C YLR278C Zinc-cluster protein genetic 1 1 1 Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 1 1 1 Negative Genetic
SWM2 YNR004W Protein with a role in snRNA and snoRNA cap trimethylation genetic 1 1 1 Negative Genetic
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Synthetic Rescue
TIP41 YPR040W Tap42p-interacting protein genetic 1 1 1 Synthetic Rescue
TAP42 YMR028W Essential protein involved in the TOR signaling pathway genetic 1 1 1 Synthetic Rescue
RIO1 YOR119C Serine kinase involved in cell cycle regulation and rDNA integrity genetic 1 1 1 Positive Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Rescue
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 1 1 1 Synthetic Rescue
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Rescue
SIR1 YKR101W Protein involved in silencing at mating-type loci HML and HMR genetic 1 1 1 Synthetic Rescue
SHU2 YDR078C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Rescue
SHU1 YHL006C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Rescue
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 1 1 1 Synthetic Rescue
SEN1 YLR430W ATP-dependent 5' to 3' RNA/DNA and DNA helicase genetic 1 1 1 Synthetic Growth Defect
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes physical 1 1 1 Affinity Capture-Western
MCM4 YPR019W Essential helicase component of heterohexameric MCM2-7 complexes genetic 1 1 1 Phenotypic Suppression
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p physical 1 1 1 Two-hybrid
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 1 1 1 Negative Genetic
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease physical 1 1 1 Affinity Capture-MS
MUS81 YDR386W Subunit of structure-specific Mms4p-Mus81p endonuclease genetic 1 1 1 Negative Genetic
CLN2 YPL256C G1 cyclin involved in regulation of the cell cycle genetic 1 1 1 Synthetic Rescue
MEC3 YLR288C DNA damage and meiotic pachytene checkpoint protein genetic 1 1 1 Negative Genetic
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Synthetic Growth Defect
EXO70 YJL085W Subunit of the exocyst complex genetic 1 1 1 Negative Genetic
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 1 1 1 Negative Genetic
ADH5 YBR145W Alcohol dehydrogenase isoenzyme V genetic 1 1 1 Negative Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Lethality
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Synthetic Growth Defect
CSM2 YIL132C Subunit of the Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Rescue
DDI1 YER143W Aspartic-type endopeptidase genetic 1 1 1 Negative Genetic
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Phenotypic Enhancement
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Growth Defect
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Negative Genetic
GZF3 YJL110C GATA zinc finger protein genetic 1 1 1 Dosage Rescue
HST3 YOR025W Sirtuin, histone H3 deacetylase genetic 1 1 1 Dosage Rescue
ATG19 YOL082W Receptor protein for the cytoplasm-to-vacuole targeting (Cvt) pathway physical 1 1 1 Affinity Capture-MS
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
ALY2 YJL084C Alpha arrestin, Ub-ligase adaptor for Rsp5p physical 1 1 1 Biochemical Activity
PRP5 YBR237W RNA helicase in the DEAD-box family genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Positive Genetic
AIM3 YBR108W Protein that inhibits barbed-end actin filament elongation physical 1 1 1 Biochemical Activity
AIM18 YHR198C Protein of unknown function genetic 1 1 1 Positive Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CEP3 YMR168C Essential kinetochore protein genetic 1 1 1 Negative Genetic
IPL1 YPL209C Aurora kinase of chromosomal passenger complex genetic 1 1 1 Synthetic Rescue
CDC21 YOR074C Thymidylate synthase genetic 1 1 1 Negative Genetic
CST6 YIL036W Basic leucine zipper (bZIP) transcription factor from ATF/CREB family physical 1 1 1 Affinity Capture-MS
AMD1 YML035C AMP deaminase physical 1 1 1 Biochemical Activity
AMD1 YML035C AMP deaminase genetic 1 1 1 Negative Genetic
CRP1 YHR146W Protein that binds to cruciform DNA structures physical 1 1 1 Affinity Capture-MS
MCM1 YMR043W Transcription factor genetic 1 1 1 Positive Genetic
BRN1 YBL097W Subunit of the condensin complex genetic 1 1 1 Negative Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Negative Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 1 1 1 Synthetic Growth Defect
BNI5 YNL166C Linker protein responsible for recruitment of myosin to the bud neck physical 1 1 1 Affinity Capture-MS
GEA1 YJR031C Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs) physical 1 1 1 Two-hybrid
BIK1 YCL029C Microtubule-associated protein genetic 1 1 1 Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 1 1 1 Synthetic Rescue
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Growth Defect
HSF1 YGL073W Trimeric heat shock transcription factor genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system physical 1 1 1 Affinity Capture-MS
PCL1 YNL289W Cyclin, interacts with cyclin-dependent kinase Pho85p genetic 1 1 1 Dosage Rescue
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Synthetic Growth Defect
ARG82 YDR173C Inositol polyphosphate multikinase (IPMK) genetic 1 1 1 Dosage Rescue
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
ESC1 YMR219W Protein involved in telomeric silencing genetic 1 1 1 Synthetic Rescue
ESC2 YDR363W Sumo-like domain protein genetic 1 1 1 Negative Genetic
HFA1 YMR207C Mitochondrial acetyl-coenzyme A carboxylase genetic 1 1 1 Positive Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 1 1 1 Synthetic Growth Defect
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 1 1 1 Synthetic Growth Defect
HHT2 YNL031C Histone H3 physical 1 1 1 Affinity Capture-Western
APN2 YBL019W Class II abasic (AP) endonuclease involved in repair of DNA damage genetic 1 1 1 Synthetic Lethality
PMT3 YOR321W Protein O-mannosyltransferase genetic 1 1 1 Negative Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ENV11 YGR071C Protein proposed to be involved in vacuolar functions physical 1 1 1 Affinity Capture-MS
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Negative Genetic
EAF6 YJR082C Subunit of the NuA4 acetyltransferase complex genetic 1 1 1 Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Growth Defect
IXR1 YKL032C Transcriptional repressor that regulates hypoxic genes during normoxia genetic 1 1 1 Phenotypic Suppression
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 1 1 1 Synthetic Growth Defect
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
ASF2 YDL197C Anti-silencing protein genetic 1 1 1 Dosage Rescue
IFH1 YLR223C Coactivator, regulates transcription of ribosomal protein (RP) genes physical 1 1 1 Affinity Capture-MS
MMS1 YPR164W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 1 1 1 Synthetic Growth Defect
PSG1 YKL077W Protein that promotes the transport and maturation of Pma1 with Exp1 genetic 1 1 1 Negative Genetic
BAP3 YDR046C Amino acid permease genetic 1 1 1 Negative Genetic
PSY3 YLR376C Component of Shu complex (aka PCSS complex) genetic 1 1 1 Synthetic Rescue
HRD3 YLR207W ER membrane protein that plays a central role in ERAD genetic 1 1 1 Negative Genetic
KCS1 YDR017C Inositol hexakisphosphate and inositol heptakisphosphate kinase genetic 1 1 1 Negative Genetic
RAD34 YDR314C Protein involved in nucleotide excision repair (NER) genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Synthetic Growth Defect
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis genetic 1 1 1 Negative Genetic
BRL1 YHR036W Essential nuclear envelope/ER integral membrane protein genetic 1 1 1 Negative Genetic
ATG32 YIL146C Mitochondrial outer membrane protein required to initiate mitophagy genetic 1 1 1 Negative Genetic
PDR10 YOR328W ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
KIN4 YOR233W Serine/threonine protein kinase genetic 1 1 1 Phenotypic Suppression
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 1 1 1 Negative Genetic
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 1 1 1 Synthetic Rescue
PRC1 YMR297W Vacuolar carboxypeptidase Y (proteinase C, CPY) genetic 1 1 1 Positive Genetic
PAD1 YDR538W Phenylacrylic acid decarboxylase genetic 1 1 1 Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Positive Genetic
PRI2 YKL045W Subunit of DNA primase genetic 1 1 1 Negative Genetic
ACL4 YDR161W Specific assembly chaperone for ribosomal protein Rpl4a/Rpl4b genetic 1 1 1 Negative Genetic
CMK2 YOL016C Calmodulin-dependent protein kinase genetic 1 1 1 Negative Genetic
CMR3 YPR013C Putative zinc finger protein physical 1 1 1 Biochemical Activity
ICS2 YBR157C Protein of unknown function genetic 1 1 1 Negative Genetic
NVJ2 YPR091C Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ) physical 1 1 1 Biochemical Activity
MNR2 YKL064W Vacuolar membrane protein required for magnesium homeostasis physical 1 1 1 Affinity Capture-MS
HST4 YDR191W NAD(+)-dependent protein deacetylase genetic 1 1 1 Dosage Rescue
POT1 YIL160C 3-ketoacyl-CoA thiolase with broad chain length specificity genetic 1 1 1 Negative Genetic
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression physical 1 1 1 Biochemical Activity
NRM1 YNR009W Transcriptional co-repressor of MBF-regulated gene expression genetic 1 1 1 Synthetic Rescue
ARF3 YOR094W Glucose-repressible ADP-ribosylation factor genetic 1 1 1 Negative Genetic
MSA1 YOR066W Activator of G1-specific transcription factors MBF and SBF genetic 1 1 1 Negative Genetic
ILM1 YJR118C Protein of unknown function genetic 1 1 1 Positive Genetic
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Synthetic Growth Defect
ERS1 YCR075C Protein involved in cystine transport genetic 1 1 1 Negative Genetic
ERP6 YGL002W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) physical 1 1 1 Biochemical Activity
CTT1 YGR088W Cytosolic catalase T genetic 1 1 1 Synthetic Growth Defect
MAK31 YCR020C-A Non-catalytic subunit of N-terminal acetyltransferase of the NatC type genetic 1 1 1 Negative Genetic
ATG15 YCR068W Phospholipase genetic 1 1 1 Positive Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase physical 1 1 1 Biochemical Activity
CLB6 YGR109C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Growth Defect
NDD1 YOR372C Transcriptional activator essential for nuclear division physical 1 1 1 Affinity Capture-Western
NDD1 YOR372C Transcriptional activator essential for nuclear division genetic 1 1 1 Synthetic Rescue
APT2 YDR441C Potential adenine phosphoribosyltransferase genetic 1 1 1 Negative Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 1 1 1 Synthetic Growth Defect
PCA1 YBR295W Cadmium transporting P-type ATPase genetic 1 1 1 Negative Genetic
MDM35 YKL053C-A Mitochondrial intermembrane space protein genetic 1 1 1 Negative Genetic
HEL1 YKR017C RING finger ubiquitin ligase (E3) physical 1 1 1 Affinity Capture-Western
LDS2 YOL047C Protein Involved in spore wall assembly genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Synthetic Growth Defect
OPT2 YPR194C Oligopeptide transporter genetic 1 1 1 Negative Genetic
AIM36 YMR157C Protein of unknown function genetic 1 1 1 Negative Genetic
ATP23 YNR020C Putative metalloprotease of the mitochondrial inner membrane genetic 1 1 1 Negative Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 1 1 1 Negative Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Synthetic Rescue
NCA3 YJL116C Protein involved in mitochondrion organization genetic 1 1 1 Negative Genetic