Standard name Systematic name Name description Description
YPT6 YLR262C Rab family GTPase Rab family GTPase; required for endosome-to-Golgi, intra-Golgi retrograde, and retrograde Golgi-to-ER transport; temporarily at the Golgi, dissociating into the cytosol on arrival of the late Golgi GTPase Ypt32p; Golgi-localized form is GTP bound, while cytosolic form is GDP-bound; required for delivery of Atg9p to the phagophore assembly site during autophagy under heat stress, with Ypt6p for starvation induced autophagy and for the CVT pathway; homolog of mammalian Rab6
Visualize the interactome of YPT6
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.956 0.975 0.963
Mito NaN NaN 0.063

GFP localization & abundance

GFP localization GFP abundance
ambiguous 7720

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
YPT6 3 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
SWR1 YDR334W Swi2/Snf2-related ATPase genetic 11 3 10 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ARL1 YBR164C Soluble GTPase with a role in regulation of membrane traffic genetic 11 3 9 Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Dosage Rescue, Negative Genetic, Negative Genetic, Dosage Rescue
SYS1 YJL004C Integral membrane protein of the Golgi genetic 11 5 8 Synthetic Lethality, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Dosage Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GYP1 YOR070C Cis-golgi GTPase-activating protein (GAP) for yeast Rabs genetic 11 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 10 3 7 Synthetic Lethality, Synthetic Lethality, Dosage Rescue, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 9 3 8 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
VPS71 YML041C Nucleosome-binding component of the SWR1 complex genetic 9 2 8 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
LSM1 YJL124C Lsm (Like Sm) protein genetic 9 1 8 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
GET1 YGL020C Subunit of the GET complex genetic 9 3 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
VPS35 YJL154C Endosomal subunit of membrane-associated retromer complex genetic 9 3 7 Synthetic Lethality, Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 8 2 7 Dosage Rescue, Dosage Rescue, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 8 2 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS29 YHR012W Subunit of the membrane-associated retromer complex genetic 8 3 6 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TLG2 YOL018C Syntaxin-like t-SNARE genetic 8 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS17 YOR132W Subunit of the membrane-associated retromer complex genetic 8 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS30 YPL120W Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II genetic 8 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IMH1 YLR309C Protein involved in vesicular transport genetic 7 4 6 Synthetic Lethality, Dosage Rescue, Synthetic Growth Defect, Dosage Rescue, Dosage Rescue, Phenotypic Enhancement, Dosage Rescue
GDI1 YER136W GDP dissociation inhibitor physical 7 3 6 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, PCA, Two-hybrid, Affinity Capture-MS
RUD3 YOR216C Golgi matrix protein genetic 7 3 6 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 7 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
TRS85 YDR108W Component of transport protein particle (TRAPP) complex III genetic 7 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BRE5 YNR051C Ubiquitin protease cofactor genetic 7 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBP3 YER151C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BST1 YFL025C GPI inositol deacylase of the endoplasmic reticulum (ER) genetic 7 2 6 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
OPI3 YJR073C Methylene-fatty-acyl-phospholipid synthase genetic 7 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
PKR1 YMR123W V-ATPase assembly factor genetic 7 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG8 YML071C Component of the conserved oligomeric Golgi complex genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG5 YNL051W Component of the conserved oligomeric Golgi complex genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ERV14 YGL054C COPII-coated vesicle protein genetic 7 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKB2 YOR039W Beta' regulatory subunit of casein kinase 2 (CK2) genetic 7 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS8 YAL002W Membrane-binding component of the CORVET complex genetic 6 3 6 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
VPS72 YDR485C Htz1p-binding component of the SWR1 complex genetic 6 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 6 2 6 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 6 1 6 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
BUD13 YGL174W Subunit of the RES complex genetic 6 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 6 1 6 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SLY1 YDR189W Hydrophilic protein involved in ER/Golgi vesicle trafficking genetic 6 4 5 Dosage Rescue, Synthetic Rescue, Synthetic Lethality, Synthetic Rescue, Negative Genetic, Negative Genetic
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 6 3 5 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWC3 YAL011W Protein of unknown function genetic 6 3 5 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
COG6 YNL041C Component of the conserved oligomeric Golgi complex genetic 6 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RER1 YCL001W Protein involved in retention of membrane proteins genetic 6 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CSF1 YLR087C Protein with structural similarity to lipid transport protein Vps13p genetic 6 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CHO2 YGR157W Phosphatidylethanolamine methyltransferase (PEMT) genetic 6 2 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PSD1 YNL169C Phosphatidylserine decarboxylase of the mitochondrial inner membrane genetic 6 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 6 1 5 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
LSM6 YDR378C Lsm (Like Sm) protein genetic 6 1 5 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 6 1 5 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 6 1 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ARP6 YLR085C Actin-related protein that binds nucleosomes genetic 6 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
GCS1 YDL226C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 6 3 4 Positive Genetic, Positive Genetic, Synthetic Rescue, Phenotypic Suppression, Positive Genetic, Positive Genetic
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
EGD1 YPL037C Subunit beta1 of the nascent polypeptide-associated complex (NAC) genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MVP1 YMR004W Protein required for sorting proteins to the vacuole genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
COG7 YGL005C Component of the conserved oligomeric Golgi complex genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
ENT5 YDR153C Protein containing an N-terminal epsin-like domain genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
MRL1 YPR079W Membrane protein genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
UPF3 YGR072W Component of the nonsense-mediated mRNA decay (NMD) pathway genetic 6 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic
YPT1 YFL038C Rab family GTPase genetic 6 4 3 Dosage Rescue, Dosage Growth Defect, Negative Genetic, Negative Genetic, Dosage Rescue, Phenotypic Suppression
VPS13 YLL040C Lipid transport protein involved in prospore membrane morphogenesis genetic 6 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SNX4 YJL036W Sorting nexin genetic 5 4 5 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Phenotypic Suppression
BRE1 YDL074C E3 ubiquitin ligase genetic 5 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
FUN30 YAL019W Snf2p family member with ATP-dependent chromatin remodeling activity genetic 5 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CNB1 YKL190W Calcineurin B genetic 5 2 5 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
STV1 YMR054W Subunit a of the vacuolar-ATPase V0 domain genetic 5 2 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 5 1 5 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
APL6 YGR261C Beta3-like subunit of the yeast AP-3 complex genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PEP8 YJL053W Vacuolar protein component of the retromer genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
INP53 YOR109W Polyphosphatidylinositol phosphatase genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
USO1 YDL058W Essential protein involved in vesicle-mediated ER to Golgi transport genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SFT2 YBL102W Tetra-spanning membrane protein found mostly in the late Golgi genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
IRS4 YKR019C EH domain-containing protein genetic 5 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 5 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 5 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
PBS2 YJL128C MAP kinase kinase of the HOG signaling pathway genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting genetic 5 3 3 Negative Genetic, Synthetic Lethality, Synthetic Lethality, Phenotypic Suppression, Phenotypic Suppression
RAV2 YDR202C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 5 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWF1 YDR126W Palmitoyltransferase that acts on transmembrane proteins genetic 5 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
VAM10 YOR068C Protein involved in vacuole morphogenesis genetic 5 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HXK2 YGL253W Hexokinase isoenzyme 2 genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
CDC73 YLR418C Component of the Paf1p complex genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
VPS21 YOR089C Endosomal Rab family GTPase genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Positive Genetic
GOS1 YHL031C v-SNARE protein involved in Golgi transport genetic 4 3 4 Synthetic Lethality, Dosage Rescue, Negative Genetic, Negative Genetic
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 4 3 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
TLG1 YDR468C Essential t-SNARE that mediates fusion of vesicles with the late Golgi genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
GET2 YER083C Subunit of the GET complex genetic 4 2 4 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
GMH1 YKR030W Golgi membrane protein of unknown function genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
MTC1 YJL123C Protein of unknown function that may interact with ribosomes genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SKY1 YMR216C SR protein kinase (SRPK) genetic 4 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SUM1 YDR310C Transcriptional repressor that regulates middle-sporulation genes genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
ERG3 YLR056W C-5 sterol desaturase genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
RRP6 YOR001W Nuclear exosome exonuclease component genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
AKL1 YBR059C Ser/Thr protein kinase genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
DPL1 YDR294C Dihydrosphingosine phosphate lyase genetic 4 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SSD1 YDR293C Translational repressor genetic 4 3 3 Synthetic Lethality, Negative Genetic, Dosage Rescue, Negative Genetic
MAK3 YPR051W Catalytic subunit of the NatC type N-terminal acetyltransferase (NAT) genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
SPO7 YAL009W Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 4 3 3 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic
RAV1 YJR033C Subunit of RAVE complex (Rav1p, Rav2p, Skp1p) genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GAS1 YMR307W Beta-1,3-glucanosyltransferase required for cell wall assembly genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 4 3 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 4 3 3 Synthetic Rescue, Synthetic Growth Defect, Negative Genetic, Negative Genetic
CEX1 YOR112W Component of nuclear aminoacylation-dependent tRNA export pathway genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
APM3 YBR288C Mu3-like subunit of the clathrin associated protein complex (AP-3) genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
VAM7 YGL212W Vacuolar SNARE protein genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
YIP1 YGR172C Integral membrane protein genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
SGM1 YJR134C Protein of unknown function physical 4 2 3 Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western
CPR7 YJR032W Peptidyl-prolyl cis-trans isomerase (cyclophilin) genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
GGA1 YDR358W Golgi-localized protein with homology to gamma-adaptin genetic 4 2 3 Phenotypic Suppression, Negative Genetic, Negative Genetic, Negative Genetic
YKT6 YKL196C Vesicle membrane protein (v-SNARE) with acyltransferase activity genetic 4 2 3 Dosage Rescue, Negative Genetic, Negative Genetic, Negative Genetic
GEF1 YJR040W Voltage-gated chloride channel genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
OXR1 YPL196W Protein involved in regulation of vacuolar V-ATPase genetic 4 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
KIN2 YLR096W S/T protein kinase genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
FAR3 YMR052W Protein of unknown function genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS68 YOL129W Vacuolar membrane protein of unknown function genetic 4 1 3 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
VPS52 YDR484W Component of the GARP (Golgi-associated retrograde protein) complex physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex physical 4 3 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 4 2 2 Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Synthetic Lethality
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SCS7 YMR272C Sphingolipid alpha-hydroxylase genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
VPS9 YML097C Guanine nucleotide exchange factor (GEF) and ubiquitin receptor genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
BUD14 YAR014C Protein involved in bud-site selection genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
DCR2 YLR361C Protein phosphatase genetic 3 3 3 Synthetic Lethality, Synthetic Growth Defect, Negative Genetic
APL5 YPL195W Delta adaptin-like subunit of the clathrin associated protein complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
BNI1 YNL271C Formin genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 2 3 Positive Genetic, Positive Genetic, Negative Genetic
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 3 2 3 Synthetic Lethality, Synthetic Growth Defect, Synthetic Growth Defect
RPL2A YFR031C-A Ribosomal 60S subunit protein L2A genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
MNN10 YDR245W Subunit of a Golgi mannosyltransferase complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
NEM1 YHR004C Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) genetic 3 2 3 Dosage Rescue, Positive Genetic, Positive Genetic
GYP6 YJL044C GTPase-activating protein (GAP) for yeast Rab family member Ypt6p physical 3 2 3 Two-hybrid, Biochemical Activity, Two-hybrid
MRS6 YOR370C Rab escort protein physical 3 2 3 PCA, Two-hybrid, PCA
DSS4 YPR017C Guanine nucleotide dissociation stimulator for Sec4p genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
PPG1 YNR032W Serine protein phosphatase involved in formation of FAR complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
VAM3 YOR106W Syntaxin-like vacuolar t-SNARE genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
SED5 YLR026C cis-Golgi t-SNARE syntaxin genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
GTA1 YEL043W Protein of unknown function genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
YPT7 YML001W Rab family GTPase genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
SWA2 YDR320C Auxilin-like protein involved in vesicular transport genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
GUP1 YGL084C Plasma membrane protein involved in remodeling GPI anchors genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
CDC50 YCR094W Endosomal protein that interacts with phospholipid flippase Drs2p genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
TVP15 YDR100W Integral membrane protein genetic 3 2 3 Synthetic Growth Defect, Negative Genetic, Negative Genetic
RCE1 YMR274C Type II CAAX prenyl protease genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAP190 YKR028W Protein that forms a complex with the Sit4p protein phosphatase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
LRP1 YHR081W Nuclear exosome-associated nucleic acid binding protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CAF40 YNL288W Component of the CCR4-NOT transcriptional complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
RXT3 YDL076C Component of the Rpd3L histone deacetylase complex genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
GAL83 YER027C One of three alternate beta-subunits of the Snf1 kinase complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SNF1 YDR477W AMP-activated S/T protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
BCY1 YIL033C Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HIR3 YJR140C Subunit of the HIR complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HIR2 YOR038C Subunit of HIR nucleosome assembly complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IST3 YIR005W Component of the U2 snRNP genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DUO1 YGL061C Essential subunit of the Dam1 complex (aka DASH complex) genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
IPK1 YDR315C Inositol 1,3,4,5,6-pentakisphosphate 2-kinase genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
URE2 YNL229C Nitrogen catabolite repression transcriptional regulator genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SAC3 YDR159W mRNA export factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
OST3 YOR085W Gamma subunit of the oligosaccharyltransferase complex of the ER lumen genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
NNF2 YGR089W Protein that exhibits physical and genetic interactions with Rpb8p genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UME1 YPL139C Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 3 1 3 Positive Genetic, Positive Genetic, Positive Genetic
SUB1 YMR039C Transcriptional regulator genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS64 YDR200C Protein required for cytoplasm to vacuole targeting of proteins genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
UBC13 YDR092W E2 ubiquitin-conjugating enzyme genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network physical 3 2 2 Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton genetic 3 2 2 Negative Genetic, Positive Genetic, Negative Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 3 2 2 Negative Genetic, Dosage Lethality, Dosage Lethality
RET3 YPL010W Zeta subunit of the coatomer complex (COPI) genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 3 2 2 Synthetic Lethality, Negative Genetic, Negative Genetic
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex physical 3 2 2 Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
OCA4 YCR095C Cytoplasmic protein required for replication of Brome mosaic virus genetic 3 2 2 Positive Genetic, Negative Genetic, Positive Genetic
ILM1 YJR118C Protein of unknown function genetic 3 2 2 Positive Genetic, Negative Genetic, Negative Genetic
LCB1 YMR296C Component of serine palmitoyltransferase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
INP52 YNL106C Polyphosphatidylinositol phosphatase genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
SEC17 YBL050W Alpha-SNAP cochaperone genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
BET5 YML077W Core component of transport protein particle (TRAPP) complexes I-III genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
TRS20 YBR254C Core component of transport protein particle (TRAPP) complexes I-III genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
FAR11 YNL127W Protein involved in recovery from cell cycle arrest genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
CMP2 YML057W Calcineurin A genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
MET6 YER091C Cobalamin-independent methionine synthase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBC7 YMR022W Ubiquitin conjugating enzyme genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
INO2 YDR123C Transcription factor genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NMD2 YHR077C Protein involved in the nonsense-mediated mRNA decay (NMD) pathway genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
VTI1 YMR197C Protein involved in cis-Golgi membrane traffic genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ERG5 YMR015C C-22 sterol desaturase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ORM2 YLR350W Protein that mediates sphingolipid homeostasis genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SAC1 YKL212W Phosphatidylinositol phosphate phosphatase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RNH70 YGR276C 3'-5' exoribonuclease genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
GPI19 YDR437W Subunit of GPI-GlcNAc transferase involved in synthesis of GlcNAc-PI genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
APS3 YJL024C Small subunit of the clathrin-associated adaptor complex AP-3 genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
MOD5 YOR274W Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ENV9 YOR246C Conserved oxidoreductase involved in lipid droplet morphology genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 2 2 2 Positive Genetic, Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 2 2 2 Positive Genetic, Negative Genetic
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 2 2 2 Negative Genetic, Positive Genetic
SUP35 YDR172W Translation termination factor eRF3 genetic 2 2 2 Positive Genetic, Negative Genetic
RTT10 YPL183C WD40 domain-containing protein involved in endosomal recycling genetic 2 2 2 Positive Genetic, Negative Genetic
CTK1 YKL139W Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I) genetic 2 2 2 Negative Genetic, Positive Genetic
ESC8 YOL017W Protein involved in telomeric and mating-type locus silencing genetic 2 2 2 Synthetic Lethality, Negative Genetic
MAK10 YEL053C Non-catalytic subunit of the NatC N-terminal acetyltransferase genetic 2 2 2 Synthetic Lethality, Negative Genetic
PRP4 YPR178W Splicing factor genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
NRD1 YNL251C RNA-binding subunit of Nrd1 complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
OPI1 YHL020C Transcriptional regulator of a variety of genes genetic 2 2 2 Synthetic Lethality, Negative Genetic
SEC21 YNL287W Gamma subunit of coatomer genetic 2 2 2 Synthetic Lethality, Negative Genetic
NGG1 YDR176W Subunit of chromatin modifying histone acetyltransferase complexes genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MGA2 YIR033W ER membrane protein involved in regulation of OLE1 transcription genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 2 Synthetic Lethality, Negative Genetic
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 2 2 2 Synthetic Rescue, Positive Genetic
HEL2 YDR266C RING finger ubiquitin ligase (E3) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone genetic 2 2 2 Synthetic Lethality, Negative Genetic
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
HHO1 YPL127C Histone H1, linker histone with roles in meiosis and sporulation genetic 2 2 2 Negative Genetic, Synthetic Rescue
KIN28 YDL108W Ser/Thr protein kinase and subunit of TFIIK, a TFIIH subassembly genetic 2 2 2 Positive Genetic, Negative Genetic
ATG20 YDL113C Sorting nexin family member genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
PAP2 YOL115W Non-canonical poly(A) polymerase genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
NUP2 YLR335W Nucleoporin involved in nucleocytoplasmic transport genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B genetic 2 2 2 Synthetic Lethality, Negative Genetic
BUB3 YOR026W Kinetochore checkpoint WD40 repeat protein genetic 2 2 2 Positive Genetic, Negative Genetic
COG4 YPR105C Essential component of the conserved oligomeric Golgi complex genetic 2 2 2 Negative Genetic, Phenotypic Suppression
MDR1 YGR100W Cytoplasmic GTPase-activating protein physical 2 2 2 Affinity Capture-Western, Biochemical Activity
FRQ1 YDR373W N-myristoylated calcium-binding protein genetic 2 2 2 Positive Genetic, Negative Genetic
SRO7 YPR032W Effector of Rab GTPase Sec4p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
CIN1 YOR349W Tubulin folding factor D involved in beta-tubulin (Tub2p) folding genetic 2 2 2 Positive Genetic, Negative Genetic
INP51 YIL002C Phosphatidylinositol 4,5-bisphosphate 5-phosphatase genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
NTO1 YPR031W Subunit of the NuA3 histone acetyltransferase complex genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ANY1 YMR010W Protein involved in phospholipid flippase function genetic 2 2 2 Synthetic Lethality, Negative Genetic
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein genetic 2 2 2 Synthetic Growth Defect, Positive Genetic
SYH1 YPL105C Protein of unknown function that influences nuclear pore distribution genetic 2 2 2 Dosage Rescue, Negative Genetic
VPS5 YOR069W Nexin-1 homolog genetic 2 2 2 Synthetic Lethality, Negative Genetic
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor genetic 2 2 2 Synthetic Lethality, Negative Genetic
DAT1 YML113W DNA binding protein that recognizes oligo(dA).oligo(dT) tracts genetic 2 2 2 Positive Genetic, Negative Genetic
KHA1 YJL094C Putative K+/H+ antiporter genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
ULS1 YOR191W Swi2/Snf2-related translocase, SUMO-Targeted Ubiquitin Ligase (STUbL) genetic 2 2 2 Phenotypic Enhancement, Negative Genetic
REB1 YBR049C RNA polymerase I enhancer binding protein regulation 2 1 2 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation-chip evidence
CHD1 YER164W Chromatin remodeler that regulates various aspects of transcription genetic 2 1 2 Negative Genetic, Negative Genetic
RPB3 YIL021W RNA polymerase II third largest subunit B44 genetic 2 1 2 Negative Genetic, Negative Genetic
CKA2 YOR061W Alpha' catalytic subunit of casein kinase 2 (CK2) genetic 2 1 2 Positive Genetic, Positive Genetic
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin genetic 2 1 2 Negative Genetic, Negative Genetic
EAF5 YEL018W Non-essential subunit of the NuA4 acetyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
SAP155 YFR040W Protein required for function of the Sit4p protein phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
THP2 YHR167W Subunit of the THO and TREX complexes genetic 2 1 2 Positive Genetic, Positive Genetic
SIN4 YNL236W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
MUD1 YBR119W U1 snRNP A protein genetic 2 1 2 Negative Genetic, Negative Genetic
VIP1 YLR410W Bifunctional inositol pyrophosphate kinase and phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
BET3 YKR068C Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 2 Negative Genetic, Negative Genetic
HST1 YOL068C NAD(+)-dependent histone deacetylase genetic 2 1 2 Negative Genetic, Negative Genetic
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 2 1 2 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 2 Negative Genetic, Negative Genetic
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes genetic 2 1 2 Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
RCO1 YMR075W Essential component of the Rpd3S histone deacetylase complex genetic 2 1 2 Negative Genetic, Negative Genetic
CTI6 YPL181W Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 2 1 2 Positive Genetic, Positive Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 2 1 2 Positive Genetic, Positive Genetic
GCN5 YGR252W Catalytic subunit of ADA and SAGA histone acetyltransferase complexes genetic 2 1 2 Negative Genetic, Negative Genetic
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 2 1 2 Positive Genetic, Positive Genetic
RRD2 YPL152W Peptidyl-prolyl cis/trans-isomerase genetic 2 1 2 Positive Genetic, Positive Genetic
BCK1 YJL095W MAPKKK acting in the protein kinase C signaling pathway genetic 2 1 2 Positive Genetic, Positive Genetic
SNT1 YCR033W Set3C histone deacetylase scaffold genetic 2 1 2 Negative Genetic, Negative Genetic
GSF2 YML048W Endoplasmic reticulum (ER) localized integral membrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 2 1 2 Positive Genetic, Positive Genetic
RGP1 YDR137W Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
KNS1 YLL019C Protein kinase involved in negative regulation of PolIII transcription genetic 2 1 2 Negative Genetic, Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 2 1 2 Negative Genetic, Negative Genetic
OCA1 YNL099C Putative protein tyrosine phosphatase genetic 2 1 2 Positive Genetic, Positive Genetic
ERG6 YML008C Delta(24)-sterol C-methyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
HIR1 YBL008W Subunit of the HIR complex genetic 2 1 2 Negative Genetic, Negative Genetic
OPY1 YBR129C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
CIK1 YMR198W Kinesin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
HAP3 YBL021C Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 2 1 2 Negative Genetic, Negative Genetic
PTC6 YCR079W Mitochondrial type 2C protein phosphatase (PP2C) genetic 2 1 2 Positive Genetic, Positive Genetic
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 2 1 2 Positive Genetic, Positive Genetic
YPT52 YKR014C Endosomal Rab family GTPase genetic 2 1 2 Positive Genetic, Positive Genetic
PKH1 YDR490C Serine/threonine protein kinase genetic 2 1 2 Negative Genetic, Negative Genetic
MCM10 YIL150C Essential chromatin-associated protein genetic 2 1 2 Negative Genetic, Negative Genetic
CLG1 YGL215W Cyclin-like protein that interacts with Pho85p genetic 2 1 2 Negative Genetic, Negative Genetic
BAS1 YKR099W Myb-related transcription factor genetic 2 1 2 Positive Genetic, Positive Genetic
ASK10 YGR097W Regulator of the Fps1p glycerol channel genetic 2 1 2 Negative Genetic, Negative Genetic
MDY2 YOL111C Protein involved in inserting tail-anchored proteins into ER membranes genetic 2 1 2 Negative Genetic, Negative Genetic
BOS1 YLR078C v-SNARE (vesicle specific SNAP receptor) genetic 2 1 2 Negative Genetic, Negative Genetic
ELP4 YPL101W Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex genetic 2 1 2 Positive Genetic, Positive Genetic
HPC2 YBR215W Subunit of the HIR complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Positive Genetic, Positive Genetic
ATG8 YBL078C Ub-like protein genetic 2 1 2 Negative Genetic, Negative Genetic
DBF4 YDR052C Regulatory subunit of Cdc7p-Dbf4p kinase complex genetic 2 1 2 Negative Genetic, Negative Genetic
MDM12 YOL009C Mitochondrial outer membrane protein, ERMES complex subunit genetic 2 1 2 Negative Genetic, Negative Genetic
RAP1 YNL216W Essential DNA-binding transcription regulator that binds many loci genetic 2 1 2 Negative Genetic, Negative Genetic
HRB1 YNL004W Poly(A+) RNA-binding protein genetic 2 1 2 Positive Genetic, Positive Genetic
YIP3 YNL044W Protein localized to COPII vesicles genetic 2 1 2 Negative Genetic, Negative Genetic
HAP4 YKL109W Transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
PDR17 YNL264C Phosphatidylinositol transfer protein (PITP) genetic 2 1 2 Negative Genetic, Negative Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 2 1 2 Negative Genetic, Negative Genetic
PBP1 YGR178C Component of glucose deprivation induced stress granules genetic 2 1 2 Positive Genetic, Positive Genetic
MSB3 YNL293W Rab GTPase-activating protein physical 2 1 2 Biochemical Activity, Biochemical Activity
CQD1 YPL109C UbiB family mitochondrial protein genetic 2 1 2 Positive Genetic, Positive Genetic
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class genetic 2 1 2 Negative Genetic, Negative Genetic
VPS38 YLR360W Part of a Vps34p phosphatidylinositol 3-kinase complex genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
ENV11 YGR071C Protein proposed to be involved in vacuolar functions genetic 2 1 2 Negative Genetic, Negative Genetic
TFB2 YPL122C Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 2 1 2 Negative Genetic, Negative Genetic
TEC1 YBR083W Transcription factor targeting filamentation genes and Ty1 expression genetic 2 1 2 Positive Genetic, Positive Genetic
MRC1 YCL061C S-phase checkpoint protein required for DNA replication genetic 2 1 2 Positive Genetic, Positive Genetic
TPM1 YNL079C Major isoform of tropomyosin genetic 2 1 2 Negative Genetic, Negative Genetic
BUG1 YDL099W Cis-golgi localized protein involved in ER to Golgi transport genetic 2 1 2 Negative Genetic, Negative Genetic
HCM1 YCR065W Forkhead transcription factor genetic 2 1 2 Negative Genetic, Negative Genetic
ALG1 YBR110W Mannosyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
VMA3 YEL027W Proteolipid subunit c of the V0 domain of vacuolar H(+)-ATPase genetic 2 1 2 Negative Genetic, Negative Genetic
FAT1 YBR041W Very long chain fatty acyl-CoA synthetase and fatty acid transporter genetic 2 1 2 Positive Genetic, Positive Genetic
EDC2 YER035W RNA-binding protein that directly activates mRNA decapping genetic 2 1 2 Negative Genetic, Negative Genetic
MUK1 YPL070W Guanine nucleotide exchange factor (GEF) genetic 2 1 2 Positive Genetic, Positive Genetic
OLE1 YGL055W Delta(9) fatty acid desaturase genetic 2 1 2 Negative Genetic, Negative Genetic
TBF1 YPL128C Telobox-containing general regulatory factor genetic 2 1 2 Negative Genetic, Negative Genetic
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 2 1 2 Positive Genetic, Positive Genetic
TRS31 YDR472W Core component of transport protein particle (TRAPP) complexes I-III genetic 2 1 2 Negative Genetic, Negative Genetic
MUB1 YMR100W MYND domain-containing protein genetic 2 1 2 Positive Genetic, Positive Genetic
LDB19 YOR322C Alpha-arrestin, Ub-ligase adaptor for Rsp5p genetic 2 1 2 Negative Genetic, Negative Genetic
GPI17 YDR434W Transmembrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
RTT106 YNL206C Histone chaperone genetic 2 1 2 Negative Genetic, Negative Genetic
THR1 YHR025W Homoserine kinase genetic 2 1 2 Negative Genetic, Negative Genetic
MDM34 YGL219C Mitochondrial component of the ERMES complex genetic 2 1 2 Negative Genetic, Negative Genetic
SOK2 YMR016C Nuclear protein that negatively regulates pseudohyphal differentiation genetic 2 1 2 Negative Genetic, Negative Genetic
GOT1 YMR292W Homodimeric protein that is packaged into COPII vesicles genetic 2 1 2 Negative Genetic, Negative Genetic
CCW12 YLR110C Cell wall mannoprotein genetic 2 1 2 Negative Genetic, Negative Genetic
YKL069W YKL069W Methionine-R-sulfoxide reductase genetic 2 1 2 Negative Genetic, Negative Genetic
EDC1 YGL222C RNA-binding protein that activates mRNA decapping directly genetic 2 1 2 Negative Genetic, Negative Genetic
ATG22 YCL038C Vacuolar integral membrane protein required for efflux of amino acids genetic 2 1 2 Negative Genetic, Negative Genetic
YET1 YKL065C Endoplasmic reticulum transmembrane protein genetic 2 1 2 Negative Genetic, Negative Genetic
SUR2 YDR297W Sphinganine C4-hydroxylase genetic 2 1 2 Positive Genetic, Positive Genetic
LAS21 YJL062W Mannose-ethanolamine phosphotransferase genetic 2 1 2 Negative Genetic, Negative Genetic
CNE1 YAL058W Calnexin genetic 2 1 2 Negative Genetic, Negative Genetic
ECT1 YGR007W Ethanolamine-phosphate cytidylyltransferase genetic 2 1 2 Negative Genetic, Negative Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 1 2 Positive Genetic, Positive Genetic
DBR1 YKL149C RNA lariat debranching enzyme genetic 2 1 2 Negative Genetic, Negative Genetic
KRE5 YOR336W Protein required for beta-1,6 glucan biosynthesis genetic 2 1 2 Negative Genetic, Negative Genetic
VPS70 YJR126C Protein of unknown function involved in vacuolar protein sorting genetic 2 1 2 Negative Genetic, Negative Genetic
SEC59 YMR013C Dolichol kinase genetic 2 1 2 Negative Genetic, Negative Genetic
YKR075C YKR075C Protein of unknown function genetic 2 1 2 Negative Genetic, Negative Genetic
SEC7 YDR170C Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors genetic 2 2 1 Negative Genetic, Positive Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 2 1 Negative Genetic, Positive Genetic
YIP3 YNL044W Protein localized to COPII vesicles physical 2 2 1 Affinity Capture-Western, Two-hybrid
MVB12 YGR206W ESCRT-I subunit required to stabilize ESCRT-I core complex oligomers genetic 2 2 1 Negative Genetic, Positive Genetic
OCA6 YDR067C Cytoplasmic protein required for replication of Brome mosaic virus genetic 2 2 1 Negative Genetic, Positive Genetic
SWC4 YGR002C Component of the Swr1p complex that incorporates Htz1p into chromatin genetic 2 1 1 Negative Genetic, Negative Genetic
SAP185 YJL098W Protein that forms a complex with the Sit4p protein phosphatase genetic 2 1 1 Negative Genetic, Negative Genetic
MLH1 YMR167W Protein required for mismatch repair in mitosis and meiosis genetic 2 1 1 Positive Genetic, Positive Genetic
CMD1 YBR109C Calmodulin genetic 2 1 1 Negative Genetic, Negative Genetic
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 2 1 1 Negative Genetic, Negative Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 2 1 1 Negative Genetic, Negative Genetic
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer genetic 2 1 1 Negative Genetic, Negative Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 2 1 1 Negative Genetic, Negative Genetic
SLA1 YBL007C Cytoskeletal protein binding protein genetic 2 1 1 Positive Genetic, Positive Genetic
PRP18 YGR006W Splicing factor and component of snRNP U5 genetic 2 1 1 Negative Genetic, Negative Genetic
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 1 Positive Genetic, Positive Genetic
GET4 YOR164C Protein involved in inserting tail-anchored proteins into ER membranes genetic 2 1 1 Negative Genetic, Negative Genetic
IRA2 YOL081W GTPase-activating protein genetic 2 1 1 Negative Genetic, Negative Genetic
IDH1 YNL037C Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase genetic 2 1 1 Positive Genetic, Positive Genetic
ARE2 YNR019W Acyl-CoA:sterol acyltransferase genetic 2 1 1 Negative Genetic, Negative Genetic
PTP3 YER075C Phosphotyrosine-specific protein phosphatase genetic 2 1 1 Negative Genetic, Negative Genetic
CKI1 YLR133W Choline kinase genetic 2 1 1 Negative Genetic, Negative Genetic
ASM4 YDL088C FG-nucleoporin component of central core of nuclear pore complex (NPC) genetic 2 1 1 Negative Genetic, Negative Genetic
QCR6 YFR033C Subunit 6 of the ubiquinol cytochrome-c reductase complex genetic 2 1 1 Negative Genetic, Negative Genetic
ELO3 YLR372W Elongase genetic 2 1 1 Positive Genetic, Positive Genetic
HRD1 YOL013C Ubiquitin-protein ligase involved in ER-associated degradation (ERAD) genetic 2 1 1 Positive Genetic, Positive Genetic
DPM1 YPR183W Dolichol phosphate mannose (Dol-P-Man) synthase of ER membrane genetic 2 1 1 Negative Genetic, Negative Genetic
GPI2 YPL076W Protein involved in the synthesis of GlcNAc-PI genetic 2 1 1 Negative Genetic, Negative Genetic
MSS1 YMR023C Mitochondrial protein genetic 2 1 1 Negative Genetic, Negative Genetic
HFD1 YMR110C Dehydrogenase involved in ubiquinone and sphingolipid metabolism genetic 2 1 1 Negative Genetic, Negative Genetic
GEP5 YLR091W Protein of unknown function genetic 2 1 1 Positive Genetic, Positive Genetic
SND1 YDR186C Protein involved in SRP-independent targeting of substrates to the ER genetic 2 1 1 Negative Genetic, Negative Genetic
ATG21 YPL100W Phosphoinositide binding protein genetic 2 1 1 Positive Genetic, Positive Genetic
PIK1 YNL267W Phosphatidylinositol 4-kinase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
SYG1 YIL047C Plasma membrane protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 1 Negative Genetic, Negative Genetic
SYT1 YPR095C Guanine nucleotide exchange factor (GEF) for Arf proteins genetic 2 1 1 Positive Genetic, Positive Genetic
SRF1 YDL133W Regulator of phospholipase D (Spo14p) genetic 2 1 1 Negative Genetic, Negative Genetic
UPS1 YLR193C Phosphatidic acid transfer protein genetic 2 1 1 Positive Genetic, Positive Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 2 1 1 Negative Genetic, Negative Genetic
YIR016W YIR016W Putative protein of unknown function genetic 2 1 1 Negative Genetic, Negative Genetic
RFX1 YLR176C Major transcriptional repressor of DNA-damage-regulated genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation regulation 1 1 1 DNA to cDNA expression microarray evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
CLF1 YLR117C Member of the NineTeen Complex (NTC) genetic 1 1 1 Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
RPO21 YDL140C RNA polymerase II largest subunit B220 genetic 1 1 1 Negative Genetic
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
CKA1 YIL035C Alpha catalytic subunit of casein kinase 2 (CK2) genetic 1 1 1 Negative Genetic
TFG1 YGR186W TFIIF (Transcription Factor II) largest subunit genetic 1 1 1 Negative Genetic
GLC7 YER133W Type 1 S/T protein phosphatase (PP1) catalytic subunit genetic 1 1 1 Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
NOP2 YNL061W rRNA m5C methyltransferase genetic 1 1 1 Negative Genetic
PFK27 YOL136C 6-phosphofructo-2-kinase genetic 1 1 1 Negative Genetic
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
POP4 YBR257W Subunit of both RNase MRP and nuclear RNase P genetic 1 1 1 Negative Genetic
RMP1 YLR145W Subunit of RNase MRP genetic 1 1 1 Negative Genetic
PRP43 YGL120C RNA helicase in the DEAH-box family genetic 1 1 1 Negative Genetic
PRP8 YHR165C Component of U4/U6-U5 snRNP complex genetic 1 1 1 Negative Genetic
NSE4 YDL105W Component of the SMC5-SMC6 complex genetic 1 1 1 Negative Genetic
HAP5 YOR358W Subunit of the Hap2p/3p/4p/5p CCAAT-binding complex genetic 1 1 1 Negative Genetic
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger genetic 1 1 1 Negative Genetic
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Negative Genetic
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Positive Genetic
PUS7 YOR243C Pseudouridine synthase genetic 1 1 1 Negative Genetic
LSM3 YLR438C-A Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RRP9 YPR137W Protein involved in pre-rRNA processing genetic 1 1 1 Positive Genetic
DIS3 YOL021C Exosome core complex catalytic subunit genetic 1 1 1 Positive Genetic
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III genetic 1 1 1 Synthetic Lethality
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Negative Genetic
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
RSC8 YFR037C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
NUT1 YGL151W Component of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 1 1 1 Positive Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 1 1 1 Positive Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 1 1 1 Negative Genetic
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Negative Genetic
PTA1 YAL043C Subunit of holo-CPF genetic 1 1 1 Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
BCP1 YDR361C Essential nuclear chaperone for ribosomal protein Rpl23p genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein genetic 1 1 1 Negative Genetic
PEP1 YBL017C Type I transmembrane sorting receptor for multiple vacuolar hydrolases genetic 1 1 1 Negative Genetic
ACC1 YNR016C Acetyl-CoA carboxylase, biotin containing enzyme genetic 1 1 1 Positive Genetic
ATG14 YBR128C Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I genetic 1 1 1 Negative Genetic
ARC18 YLR370C Subunit of the ARP2/3 complex genetic 1 1 1 Positive Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Positive Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ASF1 YJL115W Nucleosome assembly factor genetic 1 1 1 Negative Genetic
BEM1 YBR200W Protein containing SH3-domains genetic 1 1 1 Negative Genetic
BET2 YPR176C Beta subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
CAP1 YKL007W Alpha subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Positive Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Positive Genetic
CCL1 YPR025C Cyclin partner of the cyclin-dependent kinase (CDK) Kin28p genetic 1 1 1 Negative Genetic
ERG26 YGL001C C-3 sterol dehydrogenase genetic 1 1 1 Negative Genetic
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 1 1 1 Negative Genetic
CLP1 YOR250C Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Negative Genetic
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 1 1 1 Negative Genetic
CYS4 YGR155W Cystathionine beta-synthase genetic 1 1 1 Negative Genetic
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
CDC23 YHR166C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
EDE1 YBL047C Scaffold protein involved in the formation of early endocytic sites genetic 1 1 1 Positive Genetic
ELP2 YGR200C Subunit of Elongator complex genetic 1 1 1 Negative Genetic
EMP24 YGL200C Component of the p24 complex genetic 1 1 1 Negative Genetic
ERP1 YAR002C-A Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity genetic 1 1 1 Negative Genetic
GGA2 YHR108W Protein that regulates Arf1p, Arf2p to facilitate Golgi trafficking genetic 1 1 1 Phenotypic Suppression
ERV25 YML012W Member of the p24 family involved in ER to Golgi transport genetic 1 1 1 Negative Genetic
ESP1 YGR098C Separase/separin, a caspase-like cysteine protease genetic 1 1 1 Synthetic Growth Defect
HHF1 YBR009C Histone H4 genetic 1 1 1 Negative Genetic
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 1 1 1 Affinity Capture-RNA
ISW1 YBR245C ATPase subunit of imitation-switch (ISWI) class chromatin remodelers genetic 1 1 1 Negative Genetic
KGD2 YDR148C Dihydrolipoyl transsuccinylase genetic 1 1 1 Negative Genetic
KIN3 YAR018C Nonessential serine/threonine protein kinase genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Positive Genetic
LSM4 YER112W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
MED11 YMR112C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 1 1 1 Affinity Capture-MS
MSH2 YOL090W Protein that binds to DNA mismatches genetic 1 1 1 Positive Genetic
MPH1 YIR002C 3'-5' DNA helicase involved in error-free bypass of DNA lesions genetic 1 1 1 Negative Genetic
ITC1 YGL133W Subunit of ATP-dependent Isw2p-Itc1p chromatin remodeling complex genetic 1 1 1 Negative Genetic
IES1 YFL013C Subunit of the INO80 chromatin remodeling complex genetic 1 1 1 Negative Genetic
ATG18 YFR021W Phosphoinositide binding protein genetic 1 1 1 Positive Genetic
NIC96 YFR002W Linker nucleoporin component of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
APM1 YPL259C Mu1-like medium subunit of the AP-1 complex genetic 1 1 1 Positive Genetic
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex genetic 1 1 1 Positive Genetic
DIG1 YPL049C MAP kinase-responsive inhibitor of the Ste12p transcription factor genetic 1 1 1 Negative Genetic
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Dosage Rescue
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Positive Genetic
HSP82 YPL240C Hsp90 chaperone physical 1 1 1 Affinity Capture-MS
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
LEA1 YPL213W Component of U2 snRNP complex genetic 1 1 1 Negative Genetic
PTC4 YBR125C Cytoplasmic type 2C protein phosphatase (PP2C) genetic 1 1 1 Negative Genetic
MET18 YIL128W Component of cytosolic iron-sulfur protein assembly (CIA) machinery genetic 1 1 1 Positive Genetic
RAD3 YER171W 5' to 3' DNA helicase genetic 1 1 1 Negative Genetic
RNA14 YMR061W Component of the cleavage and polyadenylation factor I (CF I) genetic 1 1 1 Positive Genetic
PGD1 YGL025C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPB11 YOL005C RNA polymerase II subunit B12.5 genetic 1 1 1 Negative Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
MAF1 YDR005C Highly conserved negative regulator of RNA polymerase III genetic 1 1 1 Phenotypic Suppression
RPC53 YDL150W RNA polymerase III subunit C53 genetic 1 1 1 Negative Genetic
CSI1 YMR025W Subunit of the Cop9 signalosome genetic 1 1 1 Positive Genetic
VPS51 YKR020W Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Synthetic Lethality
SAM1 YLR180W S-adenosylmethionine synthetase genetic 1 1 1 Negative Genetic
HOS2 YGL194C Histone deacetylase and subunit of Set3 and Rpd3L complexes genetic 1 1 1 Negative Genetic
SIF2 YBR103W WD40 repeat-containing subunit of Set3C histone deacetylase complex genetic 1 1 1 Negative Genetic
HOS4 YIL112W Subunit of the Set3 complex genetic 1 1 1 Positive Genetic
SIR2 YDL042C Conserved NAD+ dependent histone deacetylase of the Sirtuin family genetic 1 1 1 Synthetic Growth Defect
CCT2 YIL142W Subunit beta of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Negative Genetic
ECM25 YJL201W Endocytic site protein required for stress-induced cell elongation genetic 1 1 1 Negative Genetic
SLC1 YDL052C 1-acyl-sn-glycerol-3-phosphate acyltransferase genetic 1 1 1 Negative Genetic
PRP9 YDL030W Subunit of the SF3a splicing factor complex genetic 1 1 1 Negative Genetic
SME1 YOR159C Core Sm protein Sm E genetic 1 1 1 Negative Genetic
BRR1 YPR057W snRNP protein component of spliceosomal snRNPs genetic 1 1 1 Negative Genetic
SNF12 YNR023W 73 kDa subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Negative Genetic
SNF5 YBR289W Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase genetic 1 1 1 Negative Genetic
HFI1 YPL254W Adaptor protein required for structural integrity of the SAGA complex genetic 1 1 1 Negative Genetic
MLP1 YKR095W Myosin-like protein associated with the nuclear envelope genetic 1 1 1 Positive Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Negative Genetic
STT3 YGL022W Catalytic subunit of the oligosaccharyltransferase complex of the ER l genetic 1 1 1 Negative Genetic
TAF1 YGR274C TFIID subunit, involved in RNA pol II transcription initiation genetic 1 1 1 Negative Genetic
TAF13 YML098W TFIID subunit (19 kDa) genetic 1 1 1 Negative Genetic
SBP1 YHL034C Protein that binds eIF4G and has a role in repression of translation genetic 1 1 1 Negative Genetic
NEW1 YPL226W Translation termination and ribosome biogenesis factor genetic 1 1 1 Negative Genetic
MCM2 YBL023C Protein involved in DNA replication genetic 1 1 1 Negative Genetic
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 1 1 1 Positive Genetic
ACE2 YLR131C Transcription factor required for septum destruction after cytokinesis genetic 1 1 1 Negative Genetic
VMA10 YHR039C-A Subunit G of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
VMA7 YGR020C Subunit F of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
VAM6 YDL077C Guanine nucleotide exchange factor for the GTPase Gtr1p physical 1 1 1 Two-hybrid
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes physical 1 1 1 Two-hybrid
VPS53 YJL029C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
VRP1 YLR337C Verprolin, proline-rich actin-associated protein genetic 1 1 1 Positive Genetic
FLC2 YAL053W Putative calcium channel involved in calcium release under hypotonic genetic 1 1 1 Negative Genetic
SET1 YHR119W Histone methyltransferase, subunit of the COMPASS (Set1C) complex genetic 1 1 1 Negative Genetic
SPP1 YPL138C Subunit of COMPASS (Set1C) genetic 1 1 1 Negative Genetic
PIN4 YBL051C Protein involved in G2/M phase progression and response to DNA damage genetic 1 1 1 Positive Genetic
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 1 1 1 Affinity Capture-MS
SSU72 YNL222W Phosphatase and transcription/RNA-processing factor genetic 1 1 1 Negative Genetic
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton genetic 1 1 1 Positive Genetic
CRZ1 YNL027W Transcription factor, activates transcription of stress response genes genetic 1 1 1 Positive Genetic
ACO1 YLR304C Aconitase physical 1 1 1 Affinity Capture-MS
FAR8 YMR029C Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
ADR1 YDR216W Carbon source-responsive zinc-finger transcription factor genetic 1 1 1 Negative Genetic
MMS2 YGL087C Ubiquitin-conjugating enzyme variant genetic 1 1 1 Negative Genetic
PHO85 YPL031C Cyclin-dependent kinase physical 1 1 1 Biochemical Activity
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Negative Genetic
RIM15 YFL033C Protein kinase involved in cell proliferation in response to nutrients genetic 1 1 1 Synthetic Lethality
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 1 1 1 Two-hybrid
NMD5 YJR132W Karyopherin genetic 1 1 1 Positive Genetic
BUB2 YMR055C Mitotic exit network regulator genetic 1 1 1 Negative Genetic
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase genetic 1 1 1 Positive Genetic
YCK1 YHR135C Palmitoylated plasma membrane-bound casein kinase I (CK1) isoform genetic 1 1 1 Negative Genetic
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Positive Genetic
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 genetic 1 1 1 Positive Genetic
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex genetic 1 1 1 Negative Genetic
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Negative Genetic
PCT1 YGR202C Cholinephosphate cytidylyltransferase genetic 1 1 1 Negative Genetic
CBK1 YNL161W Serine/threonine protein kinase of the the RAM signaling network genetic 1 1 1 Synthetic Lethality
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
GAC1 YOR178C Regulatory subunit for Glc7p type-1 protein phosphatase (PP1) genetic 1 1 1 Negative Genetic
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone genetic 1 1 1 Negative Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes genetic 1 1 1 Negative Genetic
FAR10 YLR238W Protein involved in recovery from arrest in response to pheromone genetic 1 1 1 Negative Genetic
SPO12 YHR152W Nucleolar protein of unknown function genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 1 1 1 Affinity Capture-MS
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Positive Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 1 1 1 Synthetic Lethality
RSN1 YMR266W Membrane protein of unknown function genetic 1 1 1 Synthetic Lethality
ADD66 YKL206C Protein involved in 20S proteasome assembly genetic 1 1 1 Positive Genetic
CIN8 YEL061C Bipolar kinesin motor protein genetic 1 1 1 Negative Genetic
DIA2 YOR080W Origin-binding F-box protein genetic 1 1 1 Synthetic Growth Defect
CTF4 YPR135W Chromatin-associated protein genetic 1 1 1 Negative Genetic
RAS2 YNL098C GTP-binding protein genetic 1 1 1 Positive Genetic
BUD7 YOR299W Member of the ChAPs family (Chs5p-Arf1p-binding proteins) genetic 1 1 1 Negative Genetic
SLT2 YHR030C Serine/threonine MAP kinase genetic 1 1 1 Positive Genetic
BEM4 YPL161C Protein involved in establishment of cell polarity and bud emergence genetic 1 1 1 Synthetic Lethality
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) genetic 1 1 1 Positive Genetic
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Positive Genetic
SWI5 YDR146C Transcription factor that recruits Mediator and Swi/Snf complexes genetic 1 1 1 Negative Genetic
NOP53 YPL146C Nucleolar protein genetic 1 1 1 Negative Genetic
RTT103 YDR289C Protein involved in transcription termination by RNA polymerase II genetic 1 1 1 Negative Genetic
ELC1 YPL046C Elongin C, conserved among eukaryotes genetic 1 1 1 Positive Genetic
VAN1 YML115C Component of the mannan polymerase I genetic 1 1 1 Negative Genetic
SPT2 YER161C Protein involved in negative regulation of transcription genetic 1 1 1 Positive Genetic
VPS21 YOR089C Endosomal Rab family GTPase physical 1 1 1 Two-hybrid
NDE1 YMR145C Mitochondrial external NADH dehydrogenase genetic 1 1 1 Positive Genetic
RAD53 YPL153C DNA damage response kinase genetic 1 1 1 Synthetic Growth Defect
SAN1 YDR143C Ubiquitin-protein ligase genetic 1 1 1 Negative Genetic
CTR1 YPR124W High-affinity copper transporter of plasma membrane genetic 1 1 1 Negative Genetic
SSL2 YIL143C Component of RNA polymerase transcription factor TFIIH holoenzyme genetic 1 1 1 Negative Genetic
MSG5 YNL053W Dual-specificity protein phosphatase genetic 1 1 1 Positive Genetic
FCF1 YDR339C PINc domain endonuclease genetic 1 1 1 Positive Genetic
RAD26 YJR035W Protein involved in transcription-coupled nucleotide excision repair genetic 1 1 1 Positive Genetic
ATG5 YPL149W Conserved protein involved in autophagy and the Cvt pathway genetic 1 1 1 Phenotypic Suppression
CDH1 YGL003C Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Positive Genetic
PHO86 YJL117W Endoplasmic reticulum (ER) resident protein genetic 1 1 1 Negative Genetic
VMA8 YEL051W Subunit D of the V1 peripheral membrane domain of V-ATPase genetic 1 1 1 Synthetic Lethality
MGT1 YDL200C DNA repair methyltransferase (6-O-methylguanine-DNA methylase) genetic 1 1 1 Negative Genetic
CDC7 YDL017W S/T kinase and catalytic subunit of DDK (Dbf4-dependent kinase) genetic 1 1 1 Positive Genetic
YPT52 YKR014C Endosomal Rab family GTPase physical 1 1 1 Two-hybrid
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
APL4 YPR029C Gamma-adaptin genetic 1 1 1 Positive Genetic
ASI3 YNL008C Subunit of the inner nuclear membrane Asi ubiquitin ligase complex genetic 1 1 1 Negative Genetic
ATP7 YKL016C Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
TVP23 YDR084C Integral membrane protein genetic 1 1 1 Synthetic Growth Defect
YIP4 YGL198W Protein that interacts with Rab GTPases physical 1 1 1 Reconstituted Complex
CLN3 YAL040C G1 cyclin involved in cell cycle progression genetic 1 1 1 Positive Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 1 1 1 Synthetic Growth Defect
ENT3 YJR125C Protein containing an N-terminal epsin-like domain genetic 1 1 1 Negative Genetic
CUP2 YGL166W Copper-binding transcription factor genetic 1 1 1 Negative Genetic
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Positive Genetic
GTR1 YML121W Subunit of a TORC1-stimulating GTPase and the EGO/GSE complex genetic 1 1 1 Positive Genetic
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MAD3 YJL013C Subunit of spindle-assembly checkpoint complex genetic 1 1 1 Negative Genetic
MSN5 YDR335W Karyopherin genetic 1 1 1 Negative Genetic
COG2 YGR120C Essential component of the conserved oligomeric Golgi complex physical 1 1 1 Reconstituted Complex
HSP10 YOR020C Mitochondrial matrix co-chaperonin genetic 1 1 1 Negative Genetic
NUP57 YGR119C FG-nucleoporin component of central core of the nuclear pore complex genetic 1 1 1 Negative Genetic
MND2 YIR025W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RAD4 YER162C Damaged-DNA binding subunit of Nuclear Excision Repair Factor 2 genetic 1 1 1 Synthetic Lethality
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Positive Genetic
IME1 YJR094C Master regulator of meiosis that is active only during meiotic events genetic 1 1 1 Positive Genetic
GNP1 YDR508C Broad specificity amino acid permease genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Phenotypic Enhancement
PET191 YJR034W Protein required for assembly of cytochrome c oxidase genetic 1 1 1 Positive Genetic
SRL2 YLR082C Protein of unknown function genetic 1 1 1 Positive Genetic
STD1 YOR047C Protein involved in control of glucose-regulated gene expression genetic 1 1 1 Negative Genetic
STB2 YMR053C Protein that interacts with Sin3p in a two-hybrid assay genetic 1 1 1 Negative Genetic
VMA22 YHR060W Protein that is required for vacuolar H+-ATPase (V-ATPase) function genetic 1 1 1 Synthetic Lethality
BMT2 YBR141C Nucleolar S-adenosylmethionine-dependent rRNA methyltransferase genetic 1 1 1 Negative Genetic
SLM1 YIL105C Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p genetic 1 1 1 Positive Genetic
KEG1 YFR042W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
UGA4 YDL210W GABA (gamma-aminobutyrate) permease genetic 1 1 1 Negative Genetic
AKR2 YOR034C Ankyrin repeat-containing protein genetic 1 1 1 Negative Genetic
YIP5 YGL161C Protein that interacts with Rab GTPases genetic 1 1 1 Negative Genetic
YIF1 YNL263C Integral membrane protein physical 1 1 1 Reconstituted Complex
GPI16 YHR188C Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
OCA2 YNL056W Protein of unknown function genetic 1 1 1 Positive Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
CWC15 YDR163W Non-essential protein involved in pre-mRNA splicing genetic 1 1 1 Positive Genetic
COG1 YGL223C Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Synthetic Lethality
COG6 YNL041C Component of the conserved oligomeric Golgi complex physical 1 1 1 Two-hybrid
RPS4A YJR145C Protein component of the small (40S) ribosomal subunit genetic 1 1 1 Negative Genetic
RSC1 YGR056W Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RTG1 YOL067C Transcription factor (bHLH) involved in interorganelle communication genetic 1 1 1 Negative Genetic
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Positive Genetic
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 1 1 1 Phenotypic Suppression
IES4 YOR189W Component of the INO80 chromatiin remodeling complex genetic 1 1 1 Negative Genetic
SAS3 YBL052C Histone acetyltransferase catalytic subunit of NuA3 complex genetic 1 1 1 Negative Genetic
SWI3 YJL176C Subunit of the SWI/SNF chromatin remodeling complex genetic 1 1 1 Positive Genetic
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 1 1 1 Synthetic Lethality
PHO4 YFR034C Basic helix-loop-helix (bHLH) transcription factor of the myc-family genetic 1 1 1 Negative Genetic
RTG3 YBL103C bHLH/Zip transcription factor for retrograde (RTG) and TOR pathways genetic 1 1 1 Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 1 1 1 Positive Genetic
BUR6 YER159C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
CLC1 YGR167W Clathrin light chain genetic 1 1 1 Negative Genetic
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family genetic 1 1 1 Positive Genetic
ELO2 YCR034W Fatty acid elongase, involved in sphingolipid biosynthesis genetic 1 1 1 Positive Genetic
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Positive Genetic
MYO5 YMR109W One of two type I myosin motors genetic 1 1 1 Positive Genetic
NIS1 YNL078W Protein involved in axial bud site selection genetic 1 1 1 Negative Genetic
PAN1 YIR006C Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p genetic 1 1 1 Positive Genetic
PHO80 YOL001W Cyclin genetic 1 1 1 Negative Genetic
RPA14 YDR156W RNA polymerase I subunit A14 genetic 1 1 1 Positive Genetic
SAS4 YDR181C Subunit of the SAS complex (Sas2p, Sas4p, Sas5p) genetic 1 1 1 Positive Genetic
SBH1 YER087C-B Beta subunit of Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p) genetic 1 1 1 Synthetic Growth Defect
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Synthetic Lethality
RRD1 YIL153W Peptidyl-prolyl cis/trans-isomerase genetic 1 1 1 Positive Genetic
SKN7 YHR206W Nuclear response regulator and transcription factor genetic 1 1 1 Negative Genetic
RCY1 YJL204C F-box protein involved in recycling endocytosed proteins genetic 1 1 1 Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
STE20 YHL007C Cdc42p-activated signal transducing kinase genetic 1 1 1 Positive Genetic
STE6 YKL209C Plasma membrane ATP-binding cassette (ABC) transporter genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Growth Defect
VPS41 YDR080W Subunit of the HOPS endocytic tethering complex genetic 1 1 1 Synthetic Lethality
TRA1 YHR099W Subunit of SAGA and NuA4 histone acetyltransferase complexes genetic 1 1 1 Synthetic Growth Defect
YIP1 YGR172C Integral membrane protein physical 1 1 1 Two-hybrid
CCZ1 YBR131W Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
PHO2 YDL106C Homeobox transcription factor genetic 1 1 1 Positive Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
SSN2 YDR443C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
OST4 YDL232W Subunit of the oligosaccharyltransferase complex of the ER lumen genetic 1 1 1 Negative Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 1 1 1 Positive Genetic
GAP1 YKR039W General amino acid permease genetic 1 1 1 Phenotypic Enhancement
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat genetic 1 1 1 Negative Genetic
MPT5 YGL178W mRNA-binding protein of the PUF family physical 1 1 1 Affinity Capture-RNA
YOP1 YPR028W Reticulon-interacting protein physical 1 1 1 Affinity Capture-Western
VPS54 YDR027C Component of the GARP (Golgi-associated retrograde protein) complex genetic 1 1 1 Negative Genetic
SRM1 YGL097W Nucleotide exchange factor for Gsp1p genetic 1 1 1 Negative Genetic
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Negative Genetic
SEC2 YNL272C Guanyl-nucleotide exchange factor for the small G-protein Sec4p genetic 1 1 1 Negative Genetic
CCS1 YMR038C Copper chaperone for superoxide dismutase Sod1p genetic 1 1 1 Positive Genetic
PCL5 YHR071W Cyclin genetic 1 1 1 Positive Genetic
STE50 YCL032W Adaptor protein for various signaling pathways genetic 1 1 1 Positive Genetic
VPS4 YPR173C AAA-ATPase involved in multivesicular body (MVB) protein sorting genetic 1 1 1 Negative Genetic
BUD6 YLR319C Actin- and formin-interacting protein genetic 1 1 1 Synthetic Growth Defect
ERG25 YGR060W C-4 methyl sterol oxidase genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing genetic 1 1 1 Negative Genetic
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator genetic 1 1 1 Negative Genetic
MAC1 YMR021C Copper-sensing transcription factor genetic 1 1 1 Positive Genetic
MON1 YGL124C Subunit of a heterodimeric guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
IVY1 YDR229W Phospholipid-binding protein that interacts with both Ypt7p and Vps33p genetic 1 1 1 Phenotypic Suppression
SEN2 YLR105C Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways genetic 1 1 1 Negative Genetic
AZF1 YOR113W Zinc-finger transcription factor genetic 1 1 1 Negative Genetic
MSB4 YOL112W GTPase-activating protein of the Ras superfamily physical 1 1 1 Biochemical Activity
PFY1 YOR122C Profilin genetic 1 1 1 Synthetic Growth Defect
TOR1 YJR066W PIK-related protein kinase and rapamycin target genetic 1 1 1 Synthetic Lethality
SUR1 YPL057C Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit genetic 1 1 1 Synthetic Growth Defect
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 1 1 1 Negative Genetic
MSL5 YLR116W Component of commitment complex genetic 1 1 1 Negative Genetic
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane genetic 1 1 1 Negative Genetic
CAP2 YIL034C Beta subunit of the capping protein heterodimer (Cap1p and Cap2p) genetic 1 1 1 Positive Genetic
NVJ1 YHR195W Nuclear envelope protein genetic 1 1 1 Negative Genetic
HAC1 YFL031W Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) genetic 1 1 1 Synthetic Growth Defect
RIM20 YOR275C Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Positive Genetic
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
EIS1 YMR031C Component of the eisosome required for proper eisosome assembly genetic 1 1 1 Positive Genetic
MID1 YNL291C Stretch-activated Ca2+-permeable cation channel genetic 1 1 1 Synthetic Growth Defect
BET4 YJL031C Alpha subunit of Type II geranylgeranyltransferase genetic 1 1 1 Negative Genetic
VMA11 YPL234C Vacuolar ATPase V0 domain subunit c' genetic 1 1 1 Synthetic Lethality
STB5 YHR178W Transcription factor genetic 1 1 1 Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 1 1 1 Synthetic Growth Defect
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 1 1 1 Co-purification
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
RPL28 YGL103W Ribosomal 60S subunit protein L28 genetic 1 1 1 Negative Genetic
MOG1 YJR074W Conserved nuclear protein that interacts with GTP-Gsp1p genetic 1 1 1 Positive Genetic
GAB1 YLR459W Subunit of the glycosylphosphatidylinositol transamidase complex genetic 1 1 1 Negative Genetic
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Negative Genetic
COY1 YKL179C Golgi membrane protein with similarity to mammalian CASP genetic 1 1 1 Positive Genetic
RPL16B YNL069C Ribosomal 60S subunit protein L16B genetic 1 1 1 Synthetic Lethality
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor genetic 1 1 1 Negative Genetic
ATP18 YML081C-A Subunit of the mitochondrial F1F0 ATP synthase genetic 1 1 1 Negative Genetic
EMP70 YLR083C Protein with a role in cellular adhesion and filamentous growth genetic 1 1 1 Synthetic Lethality
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Dosage Lethality
GTB1 YDR221W Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p genetic 1 1 1 Negative Genetic
TIM21 YGR033C Nonessential component of the TIM23 complex genetic 1 1 1 Negative Genetic
ERG2 YMR202W C-8 sterol isomerase genetic 1 1 1 Positive Genetic
VMA21 YGR105W Integral membrane protein required for V-ATPase function genetic 1 1 1 Synthetic Lethality
CFD1 YIL003W Highly conserved iron-sulfur cluster binding protein genetic 1 1 1 Negative Genetic
WBP1 YEL002C Beta subunit of the oligosaccharyl transferase glycoprotein complex genetic 1 1 1 Negative Genetic
SEC11 YIR022W 18kDa catalytic subunit of the Signal Peptidase Complex (SPC) genetic 1 1 1 Negative Genetic
RIM1 YCR028C-A ssDNA-binding protein essential for mitochondrial genome maintenance genetic 1 1 1 Positive Genetic
NGR1 YBR212W RNA binding protein that negatively regulates growth rate genetic 1 1 1 Positive Genetic
BPL1 YDL141W Biotin:apoprotein ligase genetic 1 1 1 Negative Genetic
MSS4 YDR208W Phosphatidylinositol-4-phosphate 5-kinase genetic 1 1 1 Positive Genetic
PIP2 YOR363C Autoregulatory, oleate-activated transcription factor genetic 1 1 1 Negative Genetic
TRS23 YDR246W Core component of transport protein particle (TRAPP) complexes I-III genetic 1 1 1 Negative Genetic
RAD30 YDR419W DNA polymerase eta genetic 1 1 1 Positive Genetic
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
UBC8 YEL012W Ubiquitin-conjugating enzyme that regulates gluconeogenesis genetic 1 1 1 Negative Genetic
GUK1 YDR454C Guanylate kinase genetic 1 1 1 Negative Genetic
UBP2 YOR124C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
PMR1 YGL167C High affinity Ca2+/Mn2+ P-type ATPase genetic 1 1 1 Positive Genetic
ACB1 YGR037C Acyl-CoA-binding protein genetic 1 1 1 Positive Genetic
TFG2 YGR005C TFIIF (Transcription Factor II) middle subunit genetic 1 1 1 Negative Genetic
PSD2 YGR170W Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes genetic 1 1 1 Negative Genetic
NOP19 YGR251W Ribosome biogenesis factor genetic 1 1 1 Negative Genetic
YNG2 YHR090C Subunit of NuA4, an essential histone acetyltransferase complex genetic 1 1 1 Negative Genetic
GCD14 YJL125C Subunit of tRNA (1-methyladenosine) methyltransferase genetic 1 1 1 Negative Genetic
MUK1 YPL070W Guanine nucleotide exchange factor (GEF) physical 1 1 1 Two-hybrid
CTP1 YBR291C Mitochondrial inner membrane citrate transporter genetic 1 1 1 Positive Genetic
THP3 YPR045C Protein that may have a role in transcription elongation genetic 1 1 1 Positive Genetic
ELF1 YKL160W Transcription elongation factor with a conserved zinc finger domain genetic 1 1 1 Positive Genetic
RTT109 YLL002W Histone acetyltransferase genetic 1 1 1 Synthetic Growth Defect
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
ZUO1 YGR285C Ribosome-associated chaperone physical 1 1 1 Affinity Capture-MS
YRM1 YOR172W Zinc finger transcription factor involved in multidrug resistance genetic 1 1 1 Positive Genetic
YTH1 YPR107C Essential RNA-binding component of cleavage and polyadenylation factor genetic 1 1 1 Positive Genetic
YSA1 YBR111C Nudix hydrolase family member with ADP-ribose pyrophosphatase activity genetic 1 1 1 Negative Genetic
YUR1 YJL139C Mannosyltransferase involved in protein N-glycosylation genetic 1 1 1 Negative Genetic
ZWF1 YNL241C Glucose-6-phosphate dehydrogenase (G6PD) genetic 1 1 1 Positive Genetic
USA1 YML029W Scaffold subunit of the Hrd1p ubiquitin ligase genetic 1 1 1 Positive Genetic
NAM2 YLR382C Mitochondrial leucyl-tRNA synthetase genetic 1 1 1 Positive Genetic
COQ6 YGR255C Flavin-dependent monooxygenase involved in ubiquinone biosynthesis genetic 1 1 1 Negative Genetic
TPS3 YMR261C Regulatory subunit of trehalose-6-phosphate synthase/phosphatase genetic 1 1 1 Positive Genetic
DSF1 YEL070W Mannitol dehydrogenase genetic 1 1 1 Negative Genetic
ROT1 YMR200W Molecular chaperone involved in protein folding in ER genetic 1 1 1 Negative Genetic
UBP14 YBR058C Ubiquitin-specific protease genetic 1 1 1 Negative Genetic
GIS2 YNL255C Translational activator for mRNAs with internal ribosome entry sites physical 1 1 1 Affinity Capture-RNA
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone genetic 1 1 1 Negative Genetic
CUP9 YPL177C Homeodomain-containing transcriptional repressor genetic 1 1 1 Negative Genetic
JID1 YPR061C Probable Hsp40p co-chaperone genetic 1 1 1 Negative Genetic
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme genetic 1 1 1 Negative Genetic
TIR4 YOR009W Cell wall mannoprotein genetic 1 1 1 Negative Genetic
TUB2 YFL037W Beta-tubulin genetic 1 1 1 Synthetic Lethality
PTM1 YKL039W Protein of unknown function genetic 1 1 1 Negative Genetic
SEH1 YGL100W Subunit of the Nup84 nuclear pore and SEACAT subcomplexes genetic 1 1 1 Positive Genetic
RPL35A YDL191W Ribosomal 60S subunit protein L35A genetic 1 1 1 Synthetic Growth Defect
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Positive Genetic
SLM3 YDL033C tRNA-specific 2-thiouridylase genetic 1 1 1 Positive Genetic
OCA5 YHL029C Cytoplasmic protein required for replication of Brome mosaic virus genetic 1 1 1 Positive Genetic
TSC13 YDL015C Enoyl reductase genetic 1 1 1 Positive Genetic
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 1 1 1 Negative Genetic
RPL34B YIL052C Ribosomal 60S subunit protein L34B genetic 1 1 1 Negative Genetic
CAB1 YDR531W Pantothenate kinase, ATP:D-pantothenate 4'-phosphotransferase genetic 1 1 1 Positive Genetic
DEG1 YFL001W tRNA:pseudouridine synthase genetic 1 1 1 Negative Genetic
AGE2 YIL044C ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector genetic 1 1 1 Positive Genetic
AST1 YBL069W Lipid raft associated protein genetic 1 1 1 Negative Genetic
MSN4 YKL062W Stress-responsive transcriptional activator genetic 1 1 1 Negative Genetic
ENT4 YLL038C Protein of unknown function genetic 1 1 1 Synthetic Lethality
PIB2 YGL023C Phosphatidylinositol 3-phosphate binding protein genetic 1 1 1 Negative Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 1 1 1 Negative Genetic
HUR1 YGL168W Protein with a role in DNA repair genetic 1 1 1 Positive Genetic
ERG24 YNL280C C-14 sterol reductase genetic 1 1 1 Positive Genetic
TYE7 YOR344C Serine-rich protein that contains a bHLH DNA binding motif genetic 1 1 1 Negative Genetic
DOT5 YIL010W Nuclear thiol peroxidase genetic 1 1 1 Negative Genetic
SLM5 YCR024C Mitochondrial asparaginyl-tRNA synthetase genetic 1 1 1 Negative Genetic
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
DER1 YBR201W ER membrane protein that promotes export of misfolded polypeptides genetic 1 1 1 Positive Genetic
SVP26 YHR181W ER exit adaptor for Golgi mannosyltransferases genetic 1 1 1 Negative Genetic
GSC2 YGR032W Catalytic subunit of 1,3-beta-glucan synthase genetic 1 1 1 Negative Genetic
ALO1 YML086C D-Arabinono-1,4-lactone oxidase genetic 1 1 1 Negative Genetic
SSM4 YIL030C Membrane-embedded ubiquitin-protein ligase and retrotranslocase physical 1 1 1 Protein-peptide
EST2 YLR318W Reverse transcriptase subunit of the telomerase holoenzyme genetic 1 1 1 Synthetic Lethality
TED1 YIL039W GPI-glycan remodelase genetic 1 1 1 Synthetic Growth Defect
EAR1 YMR171C Specificity factor required for Rsp5p-dependent ubiquitination genetic 1 1 1 Negative Genetic
NPR1 YNL183C Protein kinase genetic 1 1 1 Negative Genetic
NCB2 YDR397C Subunit of a heterodimeric NC2 transcription regulator complex genetic 1 1 1 Negative Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Negative Genetic
SUR7 YML052W Plasma membrane protein, component of eisosomes genetic 1 1 1 Negative Genetic
SLG1 YOR008C Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway genetic 1 1 1 Positive Genetic
SDD4 YPR022C Putative transcription factor, as suggested by computational analysis genetic 1 1 1 Negative Genetic
ERG4 YGL012W C-24(28) sterol reductase genetic 1 1 1 Negative Genetic
AIM34 YMR003W Protein of unknown function genetic 1 1 1 Negative Genetic
ALG14 YBR070C Component of UDP-GlcNAc transferase genetic 1 1 1 Negative Genetic
SHR3 YDL212W Endoplasmic reticulum packaging chaperone genetic 1 1 1 Negative Genetic
ALG7 YBR243C UDP-N-acetyl-glucosamine-1-P transferase genetic 1 1 1 Negative Genetic
TMH11 YJR085C Mitochondrial protein of unknown function genetic 1 1 1 Negative Genetic
PIN2 YOR104W Exomer-dependent cargo protein genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Negative Genetic
TCD1 YHR003C tRNA threonylcarbamoyladenosine dehydratase genetic 1 1 1 Negative Genetic
SQT1 YIR012W Specific assembly chaperone for ribosomal protein Rpl10p genetic 1 1 1 Positive Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Negative Genetic
MAK31 YCR020C-A Non-catalytic subunit of N-terminal acetyltransferase of the NatC type genetic 1 1 1 Synthetic Lethality
PFA4 YOL003C Palmitoyltransferase with autoacylation activity genetic 1 1 1 Negative Genetic
CCW14 YLR390W-A Covalently linked cell wall glycoprotein genetic 1 1 1 Positive Genetic
GPI18 YBR004C Functional ortholog of human PIG-V genetic 1 1 1 Negative Genetic
STE24 YJR117W Highly conserved zinc metalloprotease genetic 1 1 1 Negative Genetic
VTS1 YOR359W Flap-structured DNA-binding and RNA-binding protein genetic 1 1 1 Negative Genetic
SED4 YCR067C Integral ER membrane protein that stimulates Sar1p GTPase activity genetic 1 1 1 Negative Genetic
MET13 YGL125W Major isozyme of methylenetetrahydrofolate reductase genetic 1 1 1 Negative Genetic
RPH1 YER169W JmjC domain-containing histone demethylase genetic 1 1 1 Positive Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Negative Genetic
JAC1 YGL018C Specialized J-protein that functions in Fe-S cluster biogenesis genetic 1 1 1 Negative Genetic
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) genetic 1 1 1 Negative Genetic
ERD1 YDR414C Predicted membrane protein required for lumenal ER protein retention genetic 1 1 1 Positive Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
FMC1 YIL098C Mitochondrial matrix protein genetic 1 1 1 Positive Genetic
MCP1 YOR228C Mitochondrial protein of unknown function involved in lipid homeostas genetic 1 1 1 Negative Genetic
CRD1 YDL142C Cardiolipin synthase genetic 1 1 1 Positive Genetic
MAL33 YBR297W MAL-activator protein genetic 1 1 1 Positive Genetic
AIM20 YIL158W Protein of unknown function genetic 1 1 1 Negative Genetic
COX16 YJL003W Mitochondrial inner membrane protein genetic 1 1 1 Negative Genetic
ALE1 YOR175C Broad-specificity lysophospholipid acyltransferase genetic 1 1 1 Positive Genetic
FMP30 YPL103C Protein with a role in maintaining mitochondrial morphology genetic 1 1 1 Negative Genetic
DFR1 YOR236W Dihydrofolate reductase involved in tetrahydrofolate biosynthesis genetic 1 1 1 Negative Genetic
ALG11 YNL048W Alpha-1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
PMP3 YDR276C Small plasma membrane protein genetic 1 1 1 Positive Genetic
TMN2 YDR107C Protein with a role in cellular adhesion and filamentous growth genetic 1 1 1 Synthetic Lethality
VAC7 YNL054W Integral vacuolar membrane protein genetic 1 1 1 Positive Genetic
SPT14 YPL175W UDP-glycosyltransferase subunit of the GPI-GnT complex genetic 1 1 1 Negative Genetic
PER1 YCR044C Protein of the endoplasmic reticulum genetic 1 1 1 Synthetic Growth Defect
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Negative Genetic
PKP1 YIL042C Mitochondrial protein kinase genetic 1 1 1 Negative Genetic
TAX4 YJL083W EH domain-containing protein genetic 1 1 1 Phenotypic Suppression
MGR2 YPL098C Subunit of the TIM23 translocase complex genetic 1 1 1 Positive Genetic
YPT10 YBR264C Rab family GTP-binding protein physical 1 1 1 Two-hybrid
SCS3 YGL126W Protein required for normal ER membrane biosynthesis in response to ER genetic 1 1 1 Negative Genetic
YET3 YDL072C Protein of unknown function genetic 1 1 1 Negative Genetic
YPT31 YER031C Rab family GTPase genetic 1 1 1 Positive Genetic
VID22 YLR373C G-quadruplex (G4) DNA binding protein genetic 1 1 1 Negative Genetic
EMP65 YER140W Integral membrane protein of the ER genetic 1 1 1 Negative Genetic
ECM14 YHR132C Conserved fungal protein with similarity to zinc carboxypeptidases genetic 1 1 1 Negative Genetic
SPP41 YDR464W Protein of unknown function genetic 1 1 1 Negative Genetic
UBR2 YLR024C Cytoplasmic ubiquitin-protein ligase (E3) genetic 1 1 1 Positive Genetic
IRC21 YMR073C Protein of unknown function genetic 1 1 1 Positive Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
SEN34 YAR008W Subunit of the tRNA splicing endonuclease genetic 1 1 1 Negative Genetic
RBH1 YJL181W Putative protein of unknown function genetic 1 1 1 Positive Genetic
MTC4 YBR255W Protein of unknown function genetic 1 1 1 Positive Genetic
THR4 YCR053W Threonine synthase genetic 1 1 1 Positive Genetic
UPC2 YDR213W Sterol regulatory element binding protein genetic 1 1 1 Negative Genetic
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane genetic 1 1 1 Negative Genetic
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes genetic 1 1 1 Negative Genetic
SSP2 YOR242C Sporulation specific protein that localizes to the spore wall genetic 1 1 1 Negative Genetic
SPO24 YPR036W-A Small (67 amino acids) protein involved in sporulation genetic 1 1 1 Negative Genetic
YPR084W YPR084W Putative protein of unknown function genetic 1 1 1 Synthetic Lethality
SYC1 YOR179C Subunit of the APT subcomplex of cleavage and polyadenylation factor genetic 1 1 1 Negative Genetic
VPH2 YKL119C Integral membrane protein required for V-ATPase function genetic 1 1 1 Negative Genetic
YBL036C YBL036C Putative non-specific single-domain racemase genetic 1 1 1 Negative Genetic
MTC6 YHR151C Protein of unknown function genetic 1 1 1 Positive Genetic
YPL113C YPL113C Glyoxylate reductase genetic 1 1 1 Positive Genetic
PAU2 YEL049W Member of the seripauperin multigene family genetic 1 1 1 Negative Genetic
ECM23 YPL021W Non-essential protein of unconfirmed function genetic 1 1 1 Negative Genetic
TUF1 YOR187W Mitochondrial translation elongation factor Tu (EF-Tu) genetic 1 1 1 Positive Genetic
TRL1 YJL087C tRNA ligase genetic 1 1 1 Positive Genetic
TEP1 YNL128W PTEN homolog with no demonstrated inositol lipid phosphatase activity genetic 1 1 1 Negative Genetic
MNL2 YLR057W Putative mannosidase involved in ER-associated protein degradation genetic 1 1 1 Negative Genetic
YDL180W YDL180W Putative protein of unknown function genetic 1 1 1 Negative Genetic
TMN3 YER113C Protein with a role in cellular adhesion and filamentous growth genetic 1 1 1 Negative Genetic
YPT32 YGL210W Rab family GTPase involved in the exocytic pathway genetic 1 1 1 Positive Genetic
YML119W YML119W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YBR287W YBR287W Protein of unknown function genetic 1 1 1 Negative Genetic
YHR078W YHR078W High osmolarity-regulated gene of unknown function genetic 1 1 1 Negative Genetic
YKL063C YKL063C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR160W YMR160W Protein of unknown function genetic 1 1 1 Positive Genetic
YPK9 YOR291W Vacuolar protein with a possible role in sequestering heavy metals genetic 1 1 1 Negative Genetic
YPR114W YPR114W Protein distantly similar to ceramide synthases, Lag1p and Lac1p genetic 1 1 1 Positive Genetic
YER079W YER079W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YER085C YER085C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YJR011C YJR011C Putative protein of unknown function genetic 1 1 1 Positive Genetic
YOR008C-A YOR008C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YDR524W-C YDR524W-C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGL188C-A YGL188C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
YGR018C YGR018C Protein of unknown function genetic 1 1 1 Negative Genetic
YNR021W YNR021W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YMR196W YMR196W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YNR068C YNR068C Putative protein of unknown function genetic 1 1 1 Negative Genetic