Standard name Systematic name Name description Description
RPN10 YHR200W Proteasome polyubiquitin receptor Proteasome polyubiquitin receptor; non-ATPase subunit of the 19S regulatory particle (RP) of the 26S proteasome that links the RP base to the lid; N-terminus plays a role in the assembly of the regulatory particle (RP); ubiquitin-interacting motif selectively binds to polyubiquitin chains; homolog of the mammalian S5a protein
Visualize the interactome of RPN10
Links to external databases:
  SGD   |   KEGG   |  

Cell cycle phase and timing of transcription peak

Cell cycle phase Time (min)

CYCLoPs localization & abundance

WT1 WT2 WT3
Cytoplasm 0.788 0.722 0.689
Vac/Vac Memb 0.165 0.338 0.464

GFP localization & abundance

GFP localization GFP abundance
cytoplasm, nucleus 17200

GO term count

Metabolism Cell cycle Cell division Signal transduction DNA replication
RPN10 1 0 0 0 0

List of interactors

Use the search utility to find the interactor you are looking for. By clicking the column headers the table will be sorted on that column. Use shift+click to sort on multiple columns. Default sorting is on number of experiments, number of unique methods and the number of publications, and alphabetical on standard name, in that order.
Standard name Systematic name Name description Type #Experiments #Methods #Publications Evidence
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle physical 33 5 26 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Co-purification
UBI4 YLL039C Ubiquitin physical 14 5 14 Far Western, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Co-crystal Structure, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
RAD23 YEL037C Protein with ubiquitin-like N terminus genetic 14 5 14 Synthetic Lethality, Phenotypic Enhancement, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Lethality, Phenotypic Suppression, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic, Synthetic Growth Defect
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome physical 13 5 10 Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Reconstituted Complex, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Co-fractionation
RPN9 YDR427W Non-ATPase regulatory subunit of the 26S proteasome physical 12 6 9 Affinity Capture-MS, Affinity Capture-MS, Two-hybrid, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Reconstituted Complex, Reconstituted Complex, PCA
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component genetic 11 5 9 Phenotypic Enhancement, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Dosage Growth Defect, Synthetic Lethality, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PRE1 YER012W Beta 4 subunit of the 20S proteasome physical 11 4 9 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-Western, Affinity Capture-Western, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome physical 10 4 8 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation
BRE1 YDL074C E3 ubiquitin ligase genetic 10 3 7 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein physical 10 4 6 Reconstituted Complex, Reconstituted Complex, Affinity Capture-Western, Far Western, Two-hybrid, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex, Reconstituted Complex
LGE1 YPL055C Protein involved in histone H2B ubiquitination genetic 9 4 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid physical 9 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-fractionation, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid physical 9 2 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
DCC1 YCL016C Subunit of a complex with Ctf8p and Ctf18p genetic 9 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes genetic 9 2 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RAD23 YEL037C Protein with ubiquitin-like N terminus physical 7 3 7 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Affinity Capture-Western
CLA4 YNL298W Cdc42p-activated signal transducing kinase genetic 7 2 7 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN12 YFR052W Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 7 5 6 Synthetic Lethality, Dosage Rescue, Negative Genetic, Positive Genetic, Positive Genetic, Synthetic Growth Defect, Negative Genetic
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid genetic 7 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Phenotypic Enhancement, Synthetic Growth Defect, Negative Genetic
SMI1 YGR229C Protein involved in the regulation of cell wall synthesis genetic 7 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Lethality, Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome physical 7 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
SDS3 YIL084C Component of the Rpd3L histone deacetylase complex genetic 7 3 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic, Negative Genetic
KAR3 YPR141C Minus-end-directed microtubule motor genetic 7 3 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
UBP6 YFR010W Ubiquitin-specific protease genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic, Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome genetic 7 2 5 Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RAD52 YML032C Protein involved in homologous recombination genetic 7 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
DSK2 YMR276W Nuclear-enriched ubiquitin-like polyubiquitin-binding protein genetic 7 5 4 Phenotypic Enhancement, Synthetic Growth Defect, Synthetic Growth Defect, Synthetic Growth Defect, Dosage Rescue, Synthetic Rescue, Dosage Lethality
SWD1 YAR003W Subunit of the COMPASS (Set1C) complex genetic 6 3 6 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
SWD3 YBR175W Essential subunit of the COMPASS (Set1C) complex genetic 6 3 6 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
SIN3 YOL004W Component of both the Rpd3S and Rpd3L histone deacetylase complexes genetic 6 3 6 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Co-purification, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GIM3 YNL153C Subunit of the heterohexameric cochaperone prefoldin complex genetic 6 2 6 Positive Genetic, Positive Genetic, Positive Genetic, Synthetic Rescue, Positive Genetic, Positive Genetic
NAS6 YGR232W Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 6 2 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes physical 6 1 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome physical 6 1 6 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UFD2 YDL190C Ubiquitin (Ub) chain assembly factor (E4) genetic 6 3 5 Synthetic Growth Defect, Negative Genetic, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RSP5 YER125W NEDD4 family E3 ubiquitin ligase physical 6 2 5 Affinity Capture-MS, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity, Biochemical Activity
SWI4 YER111C DNA binding component of the SBF complex (Swi4p-Swi6p) genetic 6 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome physical 6 3 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-Western, Co-fractionation, Affinity Capture-MS, Affinity Capture-Western
CTF18 YMR078C Subunit of a complex with Ctf8p genetic 6 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
DEP1 YAL013W Component of the Rpd3L histone deacetylase complex genetic 6 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
POL32 YJR043C Third subunit of DNA polymerase delta genetic 6 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome physical 6 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SAP30 YMR263W Component of Rpd3L histone deacetylase complex genetic 5 4 5 Synthetic Lethality, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue
FKH1 YIL131C Forkhead family transcription factor regulation 5 3 5 chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, chromatin immunoprecipitation-chip evidence, chromatin immunoprecipitation- exonuclease evidence, ChEC-Seq experiments
RPN13 YLR421C Subunit of the 19S regulatory particle of the 26S proteasome lid physical 5 2 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Co-purification
RXT2 YBR095C Component of the histone deacetylase Rpd3L complex genetic 5 2 5 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Rescue, Negative Genetic
RPN2 YIL075C Subunit of the 26S proteasome physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid physical 5 1 5 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CTF4 YPR135W Chromatin-associated protein genetic 5 3 4 Synthetic Lethality, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RPN11 YFR004W Metalloprotease subunit of 19S regulatory particle genetic 5 2 4 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
LTE1 YAL024C Protein similar to GDP/GTP exchange factors genetic 5 2 4 Synthetic Lethality, Negative Genetic, Synthetic Lethality, Negative Genetic, Negative Genetic
RPT3 YDR394W ATPase of the 19S regulatory particle of the 26S proteasome genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RTS1 YOR014W B-type regulatory subunit of protein phosphatase 2A (PP2A) genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC66 YBR171W Non-essential subunit of Sec63 complex genetic 5 1 4 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
HHF1 YBR009C Histone H4 genetic 5 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic, Negative Genetic
ULA1 YPL003W Protein that activates Rub1p (NEDD8) before neddylation genetic 5 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PHO23 YNL097C Component of the Rpd3L histone deacetylase complex genetic 4 3 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Rescue
RAD6 YGL058W Ubiquitin-conjugating enzyme (E2) genetic 4 3 4 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Synthetic Growth Defect
SGF11 YPL047W Integral subunit of SAGA histone acetyltransferase complex genetic 4 2 4 Synthetic Lethality, Negative Genetic, Negative Genetic, Negative Genetic
SHP1 YBL058W UBX domain-containing substrate adaptor for Cdc48p genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPD3 YNL330C Histone deacetylase, component of both the Rpd3S and Rpd3L complexes genetic 4 2 4 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Negative Genetic
RPT2 YDL007W ATPase of the 19S regulatory particle of the 26S proteasome physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
UBP6 YFR010W Ubiquitin-specific protease physical 4 1 4 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
GIM5 YML094W Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
GIM4 YEL003W Subunit of the heterohexameric cochaperone prefoldin complex genetic 4 1 4 Positive Genetic, Positive Genetic, Positive Genetic, Positive Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Lethality
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) genetic 4 2 3 Negative Genetic, Negative Genetic, Negative Genetic, Synthetic Growth Defect
ASF1 YJL115W Nucleosome assembly factor genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CDC20 YGL116W Activator of anaphase-promoting complex/cyclosome (APC/C) genetic 4 2 3 Synthetic Lethality, Synthetic Lethality, Negative Genetic, Negative Genetic
MRE11 YMR224C Nuclease subunit of the MRX complex with Rad50p and Xrs2p genetic 4 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
RAD27 YKL113C 5' to 3' exonuclease, 5' flap endonuclease genetic 4 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RPN6 YDL097C Essential, non-ATPase regulatory subunit of the 26S proteasome lid genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT1 YKL145W ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
RPT5 YOR117W ATPase of the 19S regulatory particle of the 26S proteasome genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
SEC28 YIL076W Epsilon-COP subunit of the coatomer genetic 4 1 3 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
GCN4 YEL009C bZIP transcriptional activator of amino acid biosynthetic genes physical 4 2 2 Reconstituted Complex, Affinity Capture-Western, Reconstituted Complex, Reconstituted Complex
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
UBS1 YBR165W Ubiquitin-conjugating enzyme suppressor that regulates Cdc34p genetic 4 1 2 Negative Genetic, Negative Genetic, Negative Genetic, Negative Genetic
PAF1 YBR279W Component of the Paf1p complex involved in transcription elongation genetic 3 3 3 Synthetic Lethality, Negative Genetic, Synthetic Rescue
RTF1 YGL244W Subunit of RNAPII-associated chromatin remodeling Paf1 complex genetic 3 3 3 Synthetic Lethality, Synthetic Rescue, Negative Genetic
IRC25 YLR021W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 3 3 3 Synthetic Growth Defect, Synthetic Lethality, Negative Genetic
RPB4 YJL140W RNA polymerase II subunit B32 genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Rescue
SSB2 YNL209W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 3 2 3 Affinity Capture-MS, Affinity Capture-MS, Co-purification
UBP8 YMR223W Ubiquitin-specific protease component of the SAGA acetylation complex genetic 3 2 3 Synthetic Lethality, Negative Genetic, Negative Genetic
SWI6 YLR182W Transcription cofactor genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
SIC1 YLR079W Cyclin-dependent kinase inhibitor (CKI) genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
RTT109 YLL002W Histone acetyltransferase genetic 3 2 3 Negative Genetic, Negative Genetic, Synthetic Growth Defect
CIK1 YMR198W Kinesin-associated protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Negative Genetic
MMS22 YLR320W Subunit of E3 ubiquitin ligase complex involved in replication repair genetic 3 2 3 Negative Genetic, Synthetic Lethality, Negative Genetic
BIM1 YER016W Microtubule plus end-tracking protein genetic 3 2 3 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
POC4 YPL144W Component of a heterodimeric Poc4p-Irc25p chaperone genetic 3 2 3 Synthetic Growth Defect, Synthetic Growth Defect, Negative Genetic
SEM1 YDR363W-A 19S proteasome regulatory particle lid subcomplex component physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
SRC1 YML034W Inner nuclear membrane protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SKI3 YPR189W Ski complex component and TPR protein genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
VPS24 YKL041W One of four subunits of the ESCRT-III complex genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
SEC61 YLR378C Conserved ER protein translocation channel genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome physical 3 1 3 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
CKS1 YBR135W Cyclin-dependent protein kinase regulatory subunit and adaptor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
DOA1 YKL213C WD-repeat protein involved in ubiquitin-mediated protein degradation genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
HSL1 YKL101W Nim1p-related protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MBP1 YDL056W Transcription factor genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CDC4 YFL009W F-box protein required for both the G1/S and G2/M phase transitions genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
CLB2 YPR119W B-type cyclin involved in cell cycle progression genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
MCK1 YNL307C Dual-specificity ser/thr and tyrosine protein kinase genetic 3 1 3 Negative Genetic, Negative Genetic, Negative Genetic
RPN4 YDL020C Transcription factor that stimulates expression of proteasome genes physical 3 2 2 Affinity Capture-Western, Co-fractionation, Affinity Capture-Western
XRS2 YDR369C FHA domain-containing component of the Mre11 complex genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
CDC3 YLR314C Component of the septin ring that is required for cytokinesis genetic 3 2 2 Negative Genetic, Positive Genetic, Negative Genetic
RAD51 YER095W Strand exchange protein genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RAD54 YGL163C DNA-dependent ATPase that stimulates strand exchange genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RAD55 YDR076W Protein that stimulates strand exchange genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RAD50 YNL250W Subunit of MRX complex with Mre11p and Xrs2p genetic 3 2 2 Negative Genetic, Synthetic Growth Defect, Synthetic Growth Defect
RPN5 YDL147W Subunit of the CSN and 26S proteasome lid complexes genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN7 YPR108W Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPT6 YGL048C ATPase of the 19S regulatory particle of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPN8 YOR261C Essential non-ATPase regulatory subunit of the 26S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SSB1 YDL229W Cytoplasmic ATPase that is a ribosome-associated molecular chaperone physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE1 YER012W Beta 4 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PRE7 YBL041W Beta 6 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
ECM29 YHL030W Scaffold protein physical 3 1 2 Affinity Capture-MS, Affinity Capture-MS, Affinity Capture-MS
PRE4 YFR050C Beta 7 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
NUP133 YKR082W Subunit of Nup84p subcomplex of nuclear pore complex (NPC) genetic 3 1 2 Positive Genetic, Positive Genetic, Positive Genetic
APC5 YOR249C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
PUP2 YGR253C Alpha 5 subunit of the 20S proteasome genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
RPL8A YHL033C Ribosomal 60S subunit protein L8A genetic 3 1 2 Negative Genetic, Negative Genetic, Negative Genetic
SET3 YKR029C Defining member of the SET3 histone deacetylase complex genetic 3 2 1 Synthetic Rescue, Synthetic Rescue, Phenotypic Suppression
PAC2 YER007W Microtubule effector required for tubulin heterodimer formation physical 3 2 1 Reconstituted Complex, Reconstituted Complex, Co-fractionation
CTF19 YPL018W Outer kinetochore protein, needed for accurate chromosome segregation genetic 2 2 2 Synthetic Rescue, Negative Genetic
SEC18 YBR080C AAA ATPase and SNARE disassembly chaperone physical 2 2 2 Affinity Capture-MS, Affinity Capture-Western
RSP5 YER125W NEDD4 family E3 ubiquitin ligase genetic 2 2 2 Positive Genetic, Synthetic Growth Defect
RTT106 YNL206C Histone chaperone genetic 2 2 2 Synthetic Lethality, Negative Genetic
RTT107 YHR154W BRCA1 C-terminal domain protein needed for recovery from DNA damage genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
SPT21 YMR179W Protein with a role in transcriptional silencing genetic 2 2 2 Negative Genetic, Synthetic Lethality
SNF4 YGL115W Activating gamma subunit of the AMP-activated Snf1p kinase complex genetic 2 2 2 Positive Genetic, Synthetic Rescue
SOH1 YGL127C Subunit of the RNA polymerase II mediator complex genetic 2 2 2 Synthetic Growth Defect, Synthetic Rescue
UBC12 YLR306W Enzyme that mediates the conjugation of Rub1p genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UTH1 YKR042W Mitochondrial inner membrane protein genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
UBX2 YML013W Bridging factor involved in ER-associated protein degradation (ERAD) genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
CDC24 YAL041W Guanine nucleotide exchange factor (GEF) for Cdc42p genetic 2 2 2 Negative Genetic, Positive Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase genetic 2 2 2 Synthetic Growth Defect, Synthetic Lethality
HSM3 YBR272C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 2 2 2 Affinity Capture-Western, Affinity Capture-MS
HDA2 YDR295C Subunit of HDA1 histone deacetylase complex genetic 2 2 2 Synthetic Growth Defect, Negative Genetic
BRE2 YLR015W Subunit of COMPASS (Set1C) complex genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
PHO85 YPL031C Cyclin-dependent kinase physical 2 2 2 Affinity Capture-MS, Biochemical Activity
CBF1 YJR060W Basic helix-loop-helix (bHLH) protein genetic 2 2 2 Synthetic Rescue, Positive Genetic
GLN3 YER040W Transcriptional activator in nitrogen catabolite repression system genetic 2 2 2 Synthetic Rescue, Positive Genetic
RPL1B YGL135W Ribosomal 60S subunit protein L1B genetic 2 2 2 Negative Genetic, Synthetic Growth Defect
MON2 YNL297C Protein with a role in endocytosis and vacuole integrity genetic 2 2 2 Synthetic Lethality, Positive Genetic
PFD1 YJL179W Subunit of heterohexameric prefoldin genetic 2 2 2 Positive Genetic, Synthetic Rescue
APQ12 YIL040W Nuclear envelope/ER integral membrane protein genetic 2 2 2 Positive Genetic, Synthetic Rescue
DED81 YHR019C Cytosolic asparaginyl-tRNA synthetase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
CKB1 YGL019W Beta regulatory subunit of casein kinase 2 (CK2) genetic 2 1 2 Positive Genetic, Positive Genetic
RPC25 YKL144C RNA polymerase III subunit C25 genetic 2 1 2 Negative Genetic, Negative Genetic
RPN1 YHR027C Non-ATPase base subunit of the 19S RP of the 26S proteasome genetic 2 1 2 Synthetic Growth Defect, Synthetic Growth Defect
RPT4 YOR259C ATPase of the 19S regulatory particle of the 26S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
SCL1 YGL011C Alpha 1 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SCS2 YER120W Integral ER membrane protein, regulates phospholipid metabolism physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
URA7 YBL039C Major CTP synthase isozyme (see also URA8) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPP0 YLR340W Conserved ribosomal protein P0 of the ribosomal stalk physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS5 YJR123W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS7A YOR096W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS15 YOL040C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS16B YDL083C Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RPS18A YDR450W Protein component of the small (40S) ribosomal subunit physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSA1 YAL005C ATPase involved in protein folding and NLS-directed nuclear transport physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
SSA2 YLL024C HSP70 family ATP-binding protein physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TDH2 YJR009C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 2 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TDH3 YGR192C Glyceraldehyde-3-phosphate dehydrogenase (GAPDH), isozyme 3 physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase genetic 2 1 2 Negative Genetic, Negative Genetic
UMP1 YBR173C Chaperone required for correct maturation of the 20S proteasome genetic 2 1 2 Negative Genetic, Negative Genetic
SSN3 YPL042C Component of the RNA polymerase II mediator complex genetic 2 1 2 Positive Genetic, Positive Genetic
THP1 YOL072W Nuclear pore-associated protein genetic 2 1 2 Positive Genetic, Positive Genetic
YKE2 YLR200W Subunit of the heterohexameric Gim/prefoldin protein complex genetic 2 1 2 Positive Genetic, Positive Genetic
SAC3 YDR159W mRNA export factor genetic 2 1 2 Positive Genetic, Positive Genetic
SLX9 YGR081C Protein required for pre-rRNA processing genetic 2 1 2 Negative Genetic, Negative Genetic
TOP1 YOL006C Topoisomerase I genetic 2 1 2 Positive Genetic, Positive Genetic
SWC5 YBR231C Component of the SWR1 complex genetic 2 1 2 Negative Genetic, Negative Genetic
RPS21B YJL136C Protein component of the small (40S) ribosomal subunit genetic 2 1 2 Negative Genetic, Negative Genetic
SRN2 YLR119W Component of the ESCRT-I complex genetic 2 1 2 Negative Genetic, Negative Genetic
SMC1 YFL008W Subunit of the multiprotein cohesin complex genetic 2 1 2 Negative Genetic, Negative Genetic
VMS1 YDR049W Peptidyl-tRNA hydrolase that releases stalled peptides from ribosomes, genetic 2 1 2 Negative Genetic, Negative Genetic
UBX4 YMR067C UBX domain-containing protein that interacts with Cdc48p genetic 2 1 2 Negative Genetic, Negative Genetic
UBA3 YPR066W Protein that activates Rub1p (NEDD8) before neddylation genetic 2 1 2 Negative Genetic, Negative Genetic
HCR1 YLR192C eIF3j component of translation initiation factor 3 (eIF3) genetic 2 1 2 Negative Genetic, Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE7 YBL041W Beta 6 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE8 YML092C Alpha 2 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
ARC15 YIL062C Subunit of the ARP2/3 complex genetic 2 1 2 Negative Genetic, Negative Genetic
CDC11 YJR076C Component of the septin ring that is required for cytokinesis genetic 2 1 2 Negative Genetic, Negative Genetic
ENO1 YGR254W Enolase I, a phosphopyruvate hydratase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
DHH1 YDL160C Cytoplasmic DEAD-box helicase and mRNA decapping activator physical 2 1 2 Affinity Capture-RNA, Affinity Capture-RNA
GFA1 YKL104C Glutamine-fructose-6-phosphate amidotransferase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
FAB1 YFR019W 1-phosphatidylinositol-3-phosphate 5-kinase genetic 2 1 2 Negative Genetic, Negative Genetic
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PAC10 YGR078C Part of the heteromeric co-chaperone GimC/prefoldin complex genetic 2 1 2 Positive Genetic, Positive Genetic
PGK1 YCR012W 3-phosphoglycerate kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
HSP82 YPL240C Hsp90 chaperone physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRE4 YFR050C Beta 7 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
INO4 YOL108C Transcription factor involved in phospholipid synthesis genetic 2 1 2 Positive Genetic, Positive Genetic
PRE9 YGR135W Alpha 3 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PDC1 YLR044C Major of three pyruvate decarboxylase isozymes physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity genetic 2 1 2 Negative Genetic, Negative Genetic
GPM1 YKL152C Tetrameric phosphoglycerate mutase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PUP3 YER094C Beta 3 subunit of the 20S proteasome physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
NUP84 YDL116W Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC) genetic 2 1 2 Positive Genetic, Positive Genetic
GSP1 YLR293C Ran GTPase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
GET2 YER083C Subunit of the GET complex genetic 2 1 2 Negative Genetic, Negative Genetic
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization genetic 2 1 2 Negative Genetic, Negative Genetic
DPB11 YJL090C DNA replication initiation protein genetic 2 1 2 Positive Genetic, Positive Genetic
MSN5 YDR335W Karyopherin genetic 2 1 2 Negative Genetic, Negative Genetic
ASK1 YKL052C Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 1 2 Negative Genetic, Negative Genetic
CDC27 YBL084C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 2 1 2 Negative Genetic, Negative Genetic
RPL9B YNL067W Ribosomal 60S subunit protein L9B physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
IES2 YNL215W Protein that associates with the INO80 chromatin remodeling complex genetic 2 1 2 Negative Genetic, Negative Genetic
MUD2 YKL074C Protein involved in early pre-mRNA splicing genetic 2 1 2 Positive Genetic, Positive Genetic
CDC19 YAL038W Pyruvate kinase physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
PRP16 YKR086W DEAH-box RNA helicase genetic 2 1 2 Negative Genetic, Negative Genetic
LRS4 YDR439W Nucleolar protein that forms a complex with Csm1p genetic 2 1 2 Positive Genetic, Positive Genetic
MNN11 YJL183W Subunit of a Golgi mannosyltransferase complex genetic 2 1 2 Negative Genetic, Negative Genetic
MIP1 YOR330C Mitochondrial DNA polymerase gamma genetic 2 1 2 Positive Genetic, Positive Genetic
RPL7A YGL076C Ribosomal 60S subunit protein L7A physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
RFA2 YNL312W Subunit of heterotrimeric Replication Protein A (RPA) genetic 2 1 2 Negative Genetic, Negative Genetic
PSA1 YDL055C GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase) physical 2 1 2 Affinity Capture-MS, Affinity Capture-MS
GPI8 YDR331W Catalytic subunit of the ER membrane GPI transamidase complex genetic 2 1 2 Positive Genetic, Positive Genetic
ICE2 YIL090W Integral ER membrane protein with type-III transmembrane domains genetic 2 1 2 Negative Genetic, Negative Genetic
MAK21 YDR060W Constituent of 66S pre-ribosomal particles genetic 2 2 1 Positive Genetic, Negative Genetic
SPT15 YER148W TATA-binding protein (TBP) genetic 2 2 1 Positive Genetic, Negative Genetic
RUB1 YDR139C Ubiquitin-like protein with similarity to mammalian NEDD8 physical 2 2 1 Co-crystal Structure, Reconstituted Complex
HSC82 YMR186W Cytoplasmic chaperone of the Hsp90 family genetic 2 2 1 Synthetic Growth Defect, Dosage Growth Defect
DAM1 YGR113W Essential subunit of the Dam1 complex (aka DASH complex) genetic 2 2 1 Positive Genetic, Negative Genetic
ARP4 YJL081C Nuclear actin-related protein involved in chromatin remodeling genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ESA1 YOR244W Catalytic subunit of the histone acetyltransferase complex (NuA4) genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
RPN2 YIL075C Subunit of the 26S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
RPN3 YER021W Essential non-ATPase regulatory subunit of the 26S proteasome lid genetic 2 1 1 Negative Genetic, Negative Genetic
XRN1 YGL173C Evolutionarily-conserved 5'-3' exonuclease genetic 2 1 1 Negative Genetic, Negative Genetic
YJR096W YJR096W Xylose and arabinose reductase genetic 2 1 1 Negative Genetic, Negative Genetic
TOF1 YNL273W Subunit of a replication-pausing checkpoint complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
STU2 YLR045C Microtubule polymerase of the XMAP215/Dis1 family genetic 2 1 1 Negative Genetic, Negative Genetic
PRE2 YPR103W Beta 5 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE5 YMR314W Alpha 6 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE6 YOL038W Alpha 4 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE3 YJL001W Beta 1 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
PRE8 YML092C Alpha 2 subunit of the 20S proteasome genetic 2 1 1 Negative Genetic, Negative Genetic
CDC10 YCR002C Component of the septin ring, required for cytokinesis genetic 2 1 1 Negative Genetic, Negative Genetic
MDM10 YAL010C Subunit of both the ERMES and the SAM complex genetic 2 1 1 Positive Genetic, Positive Genetic
PTI1 YGR156W Essential component of CPF (cleavage and polyadenylation factor) genetic 2 1 1 Negative Genetic, Negative Genetic
PTC1 YDL006W Type 2C protein phosphatase (PP2C) genetic 2 1 1 Positive Genetic, Positive Genetic
RAD18 YCR066W E3 ubiquitin ligase genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
DIA2 YOR080W Origin-binding F-box protein genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
ELG1 YOR144C Subunit of an alternative replication factor C complex genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CSM3 YMR048W Replication fork associated factor genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CTF8 YHR191C Subunit of a complex with Ctf18p genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
CYK3 YDL117W SH3-domain protein located in the bud neck and cytokinetic actin ring genetic 2 1 1 Negative Genetic, Negative Genetic
RAD57 YDR004W Protein that stimulates strand exchange genetic 2 1 1 Synthetic Growth Defect, Synthetic Growth Defect
MSC1 YML128C Protein of unknown function genetic 2 1 1 Positive Genetic, Positive Genetic
SFP1 YLR403W Regulates transcription of ribosomal protein and biogenesis genes regulation 1 1 1 DNA to cDNA expression microarray evidence
GCR1 YPL075W Transcriptional activator of genes involved in glycolysis regulation 1 1 1 DNA to cDNA expression microarray evidence
ABF1 YKL112W DNA binding protein with possible chromatin-reorganizing activity regulation 1 1 1 chromatin immunoprecipitation-chip evidence
MED4 YOR174W Subunit of the RNA polymerase II mediator complex regulation 1 1 1 chromatin immunoprecipitation-chip evidence
YAP5 YIR018W Basic leucine zipper (bZIP) iron-sensing transcription factor regulation 1 1 1 chromatin immunoprecipitation-chip evidence
UGA3 YDL170W Transcriptional activator for GABA-dependent induction of GABA genes regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CAD1 YDR423C AP-1-like basic leucine zipper (bZIP) transcriptional activator regulation 1 1 1 DNA to cDNA expression microarray evidence
AFT1 YGL071W Transcription factor involved in iron utilization and homeostasis regulation 1 1 1 chromatin immunoprecipitation-chip evidence
CTR9 YOL145C Component of the Paf1p complex involved in transcription elongation genetic 1 1 1 Negative Genetic
AME1 YBR211C Essential kinetochore protein associated with microtubules and SPBs genetic 1 1 1 Positive Genetic
DSN1 YIR010W Essential component of the outer kinetochore MIND complex genetic 1 1 1 Negative Genetic
LEO1 YOR123C Component of the Paf1 complex genetic 1 1 1 Synthetic Rescue
CBF5 YLR175W Pseudouridine synthase catalytic subunit of box H/ACA snoRNPs physical 1 1 1 Affinity Capture-MS
POB3 YML069W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) genetic 1 1 1 Negative Genetic
EAF1 YDR359C Component of the NuA4 histone acetyltransferase complex genetic 1 1 1 Negative Genetic
NOP16 YER002W Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
RPL30 YGL030W Ribosomal 60S subunit protein L30 physical 1 1 1 Affinity Capture-MS
ADH1 YOL086C Alcohol dehydrogenase physical 1 1 1 Affinity Capture-MS
KAP123 YER110C Karyopherin beta physical 1 1 1 Affinity Capture-MS
RIC1 YLR039C Protein involved in retrograde transport to the cis-Golgi network genetic 1 1 1 Positive Genetic
COR1 YBL045C Core subunit of the ubiquinol-cytochrome c reductase complex physical 1 1 1 Affinity Capture-MS
PRP19 YLL036C Splicing factor associated with the spliceosome genetic 1 1 1 Negative Genetic
BRR2 YER172C RNA-dependent ATPase RNA helicase (DEIH box) genetic 1 1 1 Negative Genetic
CDC42 YLR229C Small rho-like GTPase genetic 1 1 1 Negative Genetic
MCM21 YDR318W Component of the kinetochore sub-complex COMA genetic 1 1 1 Synthetic Rescue
KES1 YPL145C Sterol/phosphatidylinositol-4-phosphate (PI(4)P) exchanger physical 1 1 1 Affinity Capture-MS
ARC1 YGL105W Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases genetic 1 1 1 Negative Genetic
GUS1 YGL245W Glutamyl-tRNA synthetase (GluRS) genetic 1 1 1 Negative Genetic
BMH1 YER177W 14-3-3 protein, major isoform physical 1 1 1 Affinity Capture-MS
NOP58 YOR310C Protein involved in producing mature rRNAs and snoRNAs physical 1 1 1 Affinity Capture-MS
FUN12 YAL035W Translation initiation factor eIF5B physical 1 1 1 Affinity Capture-MS
MDM20 YOL076W Non-catalytic subunit of the NatB N-terminal acetyltransferase genetic 1 1 1 Negative Genetic
PAT1 YCR077C Deadenylation-dependent mRNA-decapping factor genetic 1 1 1 Synthetic Growth Defect
NOP1 YDL014W Histone glutamine methyltransferase, modifies H2A at Q105 in nucleolus physical 1 1 1 Affinity Capture-MS
DED1 YOR204W ATP-dependent DEAD-box RNA helicase with strand-annealing activity physical 1 1 1 Affinity Capture-MS
PAB1 YER165W Poly(A) binding protein genetic 1 1 1 Negative Genetic
CDC48 YDL126C AAA ATPase with protein-unfoldase activity physical 1 1 1 Affinity Capture-MS
NPL3 YDR432W RNA-binding protein genetic 1 1 1 Synthetic Growth Defect
RPA34 YJL148W RNA polymerase I subunit A34.5 genetic 1 1 1 Negative Genetic
RET1 YOR207C Second-largest subunit of RNA polymerase III physical 1 1 1 Affinity Capture-MS
RPC34 YNR003C RNA polymerase III subunit C34 genetic 1 1 1 Negative Genetic
RPA190 YOR341W RNA polymerase I largest subunit A190 physical 1 1 1 Affinity Capture-MS
RPA190 YOR341W RNA polymerase I largest subunit A190 genetic 1 1 1 Negative Genetic
RPA49 YNL248C RNA polymerase I subunit A49 genetic 1 1 1 Negative Genetic
RPB7 YDR404C RNA polymerase II subunit B16 genetic 1 1 1 Positive Genetic
RPA135 YPR010C RNA polymerase I second largest subunit A135 physical 1 1 1 Affinity Capture-MS
CBC2 YPL178W Small subunit of the heterodimeric cap binding complex with Sto1p genetic 1 1 1 Synthetic Growth Defect
GCD11 YER025W Gamma subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
MED4 YOR174W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
MED7 YOL135C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Negative Genetic
ILS1 YBL076C Cytoplasmic isoleucine-tRNA synthetase physical 1 1 1 Affinity Capture-MS
ARX1 YDR101C Nuclear export factor for the ribosomal pre-60S subunit physical 1 1 1 Affinity Capture-MS
REI1 YBR267W Cytoplasmic pre-60S factor genetic 1 1 1 Positive Genetic
RPN10 YHR200W Proteasome polyubiquitin receptor physical 1 1 1 Affinity Capture-MS
RPN14 YGL004C Evolutionarily conserved 19S regulatory particle assembly-chaperone physical 1 1 1 Affinity Capture-MS
SPT15 YER148W TATA-binding protein (TBP) physical 1 1 1 Co-fractionation
RPS0B YLR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS1B YML063W Ribosomal protein of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS3 YNL178W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS7B YNL096C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS9A YPL081W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS14B YJL191W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS17A YML024W Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
RPS19A YOL121C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS19B YNL302C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
RPS25A YGR027C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SEC53 YFL045C Phosphomannomutase genetic 1 1 1 Negative Genetic
VMA4 YOR332W Subunit E of the V1 domain of the vacuolar H+-ATPase (V-ATPase) physical 1 1 1 Affinity Capture-MS
SOK1 YDR006C Protein of unknown function physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
SEC27 YGL137W Essential beta'-coat protein of the COPI coatomer genetic 1 1 1 Positive Genetic
TPI1 YDR050C Triose phosphate isomerase, abundant glycolytic enzyme physical 1 1 1 Affinity Capture-MS
SGT2 YOR007C Glutamine-rich cytoplasmic cochaperone physical 1 1 1 Affinity Capture-MS
SER3 YER081W 3-phosphoglycerate dehydrogenase and alpha-ketoglutarate reductase physical 1 1 1 Affinity Capture-MS
SPT16 YGL207W Subunit of the heterodimeric FACT complex (Spt16p-Pob3p) physical 1 1 1 Affinity Capture-MS
SUB2 YDL084W Component of the TREX complex required for nuclear mRNA export physical 1 1 1 Affinity Capture-MS
STI1 YOR027W Evolutionarily-conserved Hsp90 cochaperone physical 1 1 1 Affinity Capture-MS
ZUO1 YGR285C Ribosome-associated chaperone physical 1 1 1 Affinity Capture-MS
TIF3 YPR163C Translation initiation factor eIF-4B physical 1 1 1 Affinity Capture-MS
TKL1 YPR074C Transketolase physical 1 1 1 Affinity Capture-MS
STM1 YLR150W Protein required for optimal translation under nutrient stress physical 1 1 1 Affinity Capture-MS
THR4 YCR053W Threonine synthase physical 1 1 1 Affinity Capture-MS
TAL1 YLR354C Transaldolase, enzyme in the non-oxidative pentose phosphate pathway physical 1 1 1 Affinity Capture-MS
ZPR1 YGR211W Essential protein with two zinc fingers physical 1 1 1 Affinity Capture-MS
TRR1 YDR353W Cytoplasmic thioredoxin reductase physical 1 1 1 Affinity Capture-MS
TPS1 YBR126C Synthase subunit of trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
TRP2 YER090W Anthranilate synthase physical 1 1 1 Affinity Capture-MS
TRP5 YGL026C Tryptophan synthase physical 1 1 1 Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone physical 1 1 1 Affinity Capture-MS
YDJ1 YNL064C Type I HSP40 co-chaperone genetic 1 1 1 Positive Genetic
SEC4 YFL005W Rab family GTPase physical 1 1 1 Affinity Capture-MS
TPS2 YDR074W Phosphatase subunit of the trehalose-6-P synthase/phosphatase complex physical 1 1 1 Affinity Capture-MS
SSE1 YPL106C ATPase component of heat shock protein Hsp90 chaperone complex physical 1 1 1 Affinity Capture-MS
TRX1 YLR043C Cytoplasmic thioredoxin isoenzyme physical 1 1 1 Affinity Capture-MS
SSH1 YBR283C Subunit of the Ssh1 translocon complex physical 1 1 1 Affinity Capture-MS
SEC14 YMR079W Phosphatidylinositol/phosphatidylcholine transfer protein physical 1 1 1 Affinity Capture-MS
SAM1 YLR180W S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
SAM1 YLR180W S-adenosylmethionine synthetase genetic 1 1 1 Synthetic Growth Defect
SEC31 YDL195W Component of the Sec13p-Sec31p complex of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
SAC6 YDR129C Fimbrin, actin-bundling protein physical 1 1 1 Affinity Capture-MS
TRX2 YGR209C Cytoplasmic thioredoxin isoenzyme physical 1 1 1 Affinity Capture-MS
VPS1 YKR001C Dynamin-like GTPase required for vacuolar sorting physical 1 1 1 Affinity Capture-MS
YIP3 YNL044W Protein localized to COPII vesicles physical 1 1 1 Affinity Capture-MS
SSZ1 YHR064C Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) physical 1 1 1 Affinity Capture-MS
UBA1 YKL210W Ubiquitin activating enzyme (E1) physical 1 1 1 Affinity Capture-MS
URA2 YJL130C Bifunctional carbamoylphosphate synthetase/aspartate transcarbamylase physical 1 1 1 Affinity Capture-MS
YMR226C YMR226C NADP(+)-dependent serine dehydrogenase and carbonyl reductase physical 1 1 1 Affinity Capture-MS
YVH1 YIR026C Dual specificity protein phosphatase physical 1 1 1 Affinity Capture-MS
SAM2 YDR502C S-adenosylmethionine synthetase physical 1 1 1 Affinity Capture-MS
SHM2 YLR058C Cytosolic serine hydroxymethyltransferase physical 1 1 1 Affinity Capture-MS
SND3 YBR106W Involved in SRP-independent protein targeting to the ER physical 1 1 1 Affinity Capture-MS
SUP35 YDR172W Translation termination factor eRF3 physical 1 1 1 Affinity Capture-MS
SEC21 YNL287W Gamma subunit of coatomer physical 1 1 1 Affinity Capture-MS
SAH1 YER043C S-adenosyl-L-homocysteine hydrolase physical 1 1 1 Affinity Capture-MS
YCP4 YCR004C Protein of unknown function physical 1 1 1 Affinity Capture-MS
TIF2 YJL138C Translation initiation factor eIF4A physical 1 1 1 Affinity Capture-MS
RPS20 YHL015W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
THR1 YHR025W Homoserine kinase physical 1 1 1 Affinity Capture-MS
VPS74 YDR372C Golgi PI4K effector, PtdIns4P sensor, and retention receptor physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase physical 1 1 1 Affinity Capture-MS
TSA1 YML028W Thioredoxin peroxidase genetic 1 1 1 Synthetic Growth Defect
YPR1 YDR368W NADPH-dependent aldo-keto reductase physical 1 1 1 Affinity Capture-MS
RPS9B YBR189W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
WRS1 YOL097C Cytoplasmic tryptophanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
TEF4 YKL081W Gamma subunit of translational elongation factor eEF1B physical 1 1 1 Affinity Capture-MS
SUI3 YPL237W Beta subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
VMA2 YBR127C Subunit B of V1 peripheral membrane domain of vacuolar H+-ATPase physical 1 1 1 Affinity Capture-MS
SPE3 YPR069C Spermidine synthase physical 1 1 1 Affinity Capture-MS
SEC26 YDR238C Essential beta-coat protein of the COPI coatomer physical 1 1 1 Affinity Capture-MS
TYS1 YGR185C Cytoplasmic tyrosyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
TMA19 YKL056C Protein that associates with ribosomes physical 1 1 1 Affinity Capture-MS
VMA13 YPR036W Subunit H of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
SUI2 YJR007W Alpha subunit of the translation initiation factor eIF2 physical 1 1 1 Affinity Capture-MS
RPS13 YDR064W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
YEF3 YLR249W Translation elongation factor 3 physical 1 1 1 Affinity Capture-MS
VPH1 YOR270C Subunit a of the vacuolar-ATPase V0 domain physical 1 1 1 Affinity Capture-MS
SEC24 YIL109C Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat physical 1 1 1 Affinity Capture-MS
RPS2 YGL123W Protein component of the small (40S) subunit physical 1 1 1 Affinity Capture-MS
RPS17B YDR447C Ribosomal protein 51 (rp51) of the small (40s) subunit physical 1 1 1 Affinity Capture-MS
VMA5 YKL080W Subunit C of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p physical 1 1 1 Affinity Capture-MS
SEC23 YPR181C GTPase-activating protein, stimulates the GTPase activity of Sar1p genetic 1 1 1 Negative Genetic
SES1 YDR023W Cytosolic seryl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
RTN1 YDR233C Reticulon protein physical 1 1 1 Affinity Capture-MS
RPS8A YBL072C Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
TIF4631 YGR162W Translation initiation factor eIF4G and scaffold protein physical 1 1 1 Affinity Capture-MS
TEF2 YBR118W Translational elongation factor EF-1 alpha physical 1 1 1 Affinity Capture-MS
SOD1 YJR104C Cytosolic copper-zinc superoxide dismutase physical 1 1 1 Affinity Capture-MS
RPS10B YMR230W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
THS1 YIL078W Threonyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
SPF1 YEL031W P-type ATPase, ion transporter of the ER membrane physical 1 1 1 Affinity Capture-MS
YDR341C YDR341C Arginyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
VMA1 YDL185W Subunit A of the V1 peripheral membrane domain of V-ATPase physical 1 1 1 Affinity Capture-MS
RPS0A YGR214W Ribosomal 40S subunit protein S0A physical 1 1 1 Affinity Capture-MS
URA8 YJR103W Minor CTP synthase isozyme (see also URA7) physical 1 1 1 Affinity Capture-MS
TRP4 YDR354W Anthranilate phosphoribosyl transferase physical 1 1 1 Affinity Capture-MS
RPS11B YBR048W Protein component of the small (40S) ribosomal subunit physical 1 1 1 Affinity Capture-MS
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination physical 1 1 1 Affinity Capture-MS
SUP45 YBR143C Polypeptide release factor (eRF1) in translation termination genetic 1 1 1 Negative Genetic
YHB1 YGR234W Nitric oxide oxidoreductase physical 1 1 1 Affinity Capture-MS
YHR020W YHR020W Prolyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
VAS1 YGR094W Mitochondrial and cytoplasmic valyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
SLF1 YDR515W RNA binding protein that associates with polysomes physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein physical 1 1 1 Affinity Capture-RNA
SRO9 YCL037C Cytoplasmic RNA-binding protein genetic 1 1 1 Synthetic Rescue
UFO1 YML088W F-box receptor protein physical 1 1 1 Affinity Capture-Western
TOM1 YDR457W E3 ubiquitin ligase of the hect-domain class physical 1 1 1 Biochemical Activity
UBC4 YBR082C Ubiquitin-conjugating enzyme (E2) physical 1 1 1 Reconstituted Complex
RVB2 YPL235W ATP-dependent DNA helicase, also known as reptin physical 1 1 1 Affinity Capture-MS
RVB1 YDR190C ATP-dependent DNA helicase, also known as pontin physical 1 1 1 Affinity Capture-MS
TFC6 YDR362C Subunit of RNA polymerase III transcription initiation factor complex physical 1 1 1 Affinity Capture-MS
SIS1 YNL007C Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p physical 1 1 1 Affinity Capture-MS
RRP6 YOR001W Nuclear exosome exonuclease component physical 1 1 1 Affinity Capture-MS
TEF1 YPR080W Translational elongation factor EF-1 alpha genetic 1 1 1 Dosage Rescue
SPT8 YLR055C Subunit of the SAGA transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
SPT3 YDR392W Subunit of the SAGA and SAGA-like transcriptional regulatory complexes genetic 1 1 1 Synthetic Lethality
SDC1 YDR469W Subunit of the COMPASS (Set1C) complex genetic 1 1 1 Synthetic Lethality
SWD2 YKL018W Subunit of the COMPASS (Set1C) histone H3K4 methyltransferase complex genetic 1 1 1 Negative Genetic
SGO1 YOR073W Component of the spindle checkpoint genetic 1 1 1 Negative Genetic
SGF73 YGL066W Subunit of DUBm module of SAGA and SLIK genetic 1 1 1 Negative Genetic
SWM1 YDR260C Subunit of the anaphase-promoting complex (APC) genetic 1 1 1 Negative Genetic
SKI8 YGL213C Ski complex component and WD-repeat protein genetic 1 1 1 Negative Genetic
VIK1 YPL253C Protein that forms a kinesin-14 heterodimeric motor with Kar3p genetic 1 1 1 Negative Genetic
TCO89 YPL180W Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p) genetic 1 1 1 Negative Genetic
UME6 YDR207C Rpd3L histone deacetylase complex subunit genetic 1 1 1 Positive Genetic
SSN8 YNL025C Cyclin-like component of RNA polymerase II holoenzyme genetic 1 1 1 Positive Genetic
SAM37 YMR060C Component of the Sorting and Assembly Machinery (SAM) complex genetic 1 1 1 Positive Genetic
VPS21 YOR089C Endosomal Rab family GTPase genetic 1 1 1 Positive Genetic
ZRT1 YGL255W High-affinity zinc transporter of the plasma membrane genetic 1 1 1 Positive Genetic
SRP1 YNL189W Karyopherin alpha homolog genetic 1 1 1 Negative Genetic
SHO1 YER118C Transmembrane osmosensor for filamentous growth and HOG pathways genetic 1 1 1 Negative Genetic
YPK3 YBR028C AGC kinase genetic 1 1 1 Positive Genetic
YPD1 YDL235C Osmotic stress-responsive phosphorelay intermediate sensor protein genetic 1 1 1 Positive Genetic
SEC63 YOR254C Essential subunit of Sec63 complex genetic 1 1 1 Negative Genetic
RVS167 YDR388W Calmodulin-binding actin-associated protein genetic 1 1 1 Synthetic Growth Defect
SAC7 YDR389W GTPase activating protein (GAP) for Rho1p genetic 1 1 1 Synthetic Growth Defect
SNF8 YPL002C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
STP22 YCL008C Component of the ESCRT-I complex genetic 1 1 1 Synthetic Growth Defect
VPS20 YMR077C Myristoylated subunit of the ESCRT-III complex genetic 1 1 1 Synthetic Growth Defect
VPS25 YJR102C Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS36 YLR417W Component of the ESCRT-II complex genetic 1 1 1 Synthetic Growth Defect
VPS45 YGL095C Protein of the Sec1p/Munc-18 family genetic 1 1 1 Synthetic Growth Defect
WSS1 YHR134W SUMO-ligase and SUMO-targeted metalloprotease genetic 1 1 1 Synthetic Growth Defect
TMA64 YDR117C Protein of unknown function that associates with ribosomes genetic 1 1 1 Synthetic Growth Defect
SRB2 YHR041C Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Growth Defect
VPS3 YDR495C Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
VPS33 YLR396C ATP-binding protein that is a subunit of the HOPS and CORVET complexes genetic 1 1 1 Synthetic Growth Defect
SBA1 YKL117W Co-chaperone that binds and regulates Hsp90 family chaperones genetic 1 1 1 Synthetic Lethality
THP2 YHR167W Subunit of the THO and TREX complexes genetic 1 1 1 Synthetic Rescue
YAF9 YNL107W Subunit of NuA4 histone H4 acetyltransferase and SWR1 complexes genetic 1 1 1 Synthetic Rescue
SRB8 YCR081W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
SPT10 YJL127C Histone H3 acetylase with a role in transcriptional regulation genetic 1 1 1 Synthetic Rescue
TRK1 YJL129C Component of the Trk1p-Trk2p potassium transport system genetic 1 1 1 Synthetic Rescue
WHI2 YOR043W Negative regulator of TORC1 in response to limiting leucine genetic 1 1 1 Synthetic Rescue
STS1 YIR011C Protein required for localizing proteasomes to the nucleus genetic 1 1 1 Phenotypic Suppression
YME1 YPR024W Catalytic subunit of i-AAA protease complex genetic 1 1 1 Positive Genetic
SHR5 YOL110W Palmitoyltransferase subunit genetic 1 1 1 Phenotypic Suppression
YKU70 YMR284W Subunit of the telomeric Ku complex (Yku70p-Yku80p) genetic 1 1 1 Negative Genetic
SMT3 YDR510W Ubiquitin-like protein of the SUMO family genetic 1 1 1 Synthetic Growth Defect
VPS27 YNR006W Endosomal protein that forms a complex with Hse1p genetic 1 1 1 Negative Genetic
TGL1 YKL140W Steryl ester hydrolase genetic 1 1 1 Negative Genetic
SEC1 YDR164C Sm-like protein involved in docking and fusion of exocytic vesicles genetic 1 1 1 Positive Genetic
TIM54 YJL054W Component of the mitochondrial TIM22 complex genetic 1 1 1 Positive Genetic
SLU7 YDR088C RNA splicing factor genetic 1 1 1 Positive Genetic
SKI6 YGR195W Exosome non-catalytic core component genetic 1 1 1 Positive Genetic
TEM1 YML064C GTPase involved in initiation of Mitotic Exit Network (MEN) genetic 1 1 1 Positive Genetic
SPC24 YMR117C Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Positive Genetic
SEC8 YPR055W Essential 121 kDa subunit of the exocyst complex genetic 1 1 1 Positive Genetic
SGV1 YPR161C Cyclin (Bur2p)-dependent protein kinase genetic 1 1 1 Positive Genetic
SNT309 YPR101W Member of the NineTeen Complex (NTC) genetic 1 1 1 Positive Genetic
RRP42 YDL111C Exosome non-catalytic core component genetic 1 1 1 Negative Genetic
STN1 YDR082W Telomere end-binding and capping protein genetic 1 1 1 Negative Genetic
UBC1 YDR177W Ubiquitin-conjugating enzyme genetic 1 1 1 Negative Genetic
RRP17 YDR412W 5' exoribonuclease required for 5' end processing of pre-60S rRNA genetic 1 1 1 Negative Genetic
SEC20 YDR498C Membrane glycoprotein v-SNARE genetic 1 1 1 Negative Genetic
UFE1 YOR075W t-SNARE protein required for retrograde vesicular traffic genetic 1 1 1 Negative Genetic
SEC16 YPL085W COPII vesicle coat protein required for ER transport vesicle budding genetic 1 1 1 Negative Genetic
TIF6 YPR016C Constituent of 66S pre-ribosomal particles genetic 1 1 1 Negative Genetic
TAF5 YBR198C Subunit (90 kDa) of TFIID and SAGA complexes genetic 1 1 1 Negative Genetic
TFB1 YDR311W Subunit of TFIIH and nucleotide excision repair factor 3 complexes genetic 1 1 1 Negative Genetic
SPC105 YGL093W Subunit of a kinetochore-microtubule binding complex genetic 1 1 1 Negative Genetic
SDS22 YKL193C Regulatory subunit of the type 1 protein phosphatase (PP1) Glc7p genetic 1 1 1 Negative Genetic
SPC3 YLR066W Subunit of signal peptidase complex genetic 1 1 1 Negative Genetic
STT4 YLR305C Phosphatidylinositol-4-kinase genetic 1 1 1 Negative Genetic
TIM23 YNR017W Essential component of the TIM23 complex genetic 1 1 1 Negative Genetic
SEC12 YNR026C Guanine nucleotide exchange factor (GEF) genetic 1 1 1 Negative Genetic
SMP3 YOR149C Alpha 1,2-mannosyltransferase genetic 1 1 1 Negative Genetic
SPN1 YPR133C Protein involved in RNA polymerase II transcription genetic 1 1 1 Negative Genetic
UBP13 YBL067C Ubiquitin-specific protease that cleaves Ub-protein fusions genetic 1 1 1 Negative Genetic
RVS161 YCR009C Amphiphysin-like lipid raft protein genetic 1 1 1 Negative Genetic
TVS1 YCR061W Protein of unknown function genetic 1 1 1 Negative Genetic
RPP1B YDL130W Ribosomal protein P1 beta genetic 1 1 1 Negative Genetic
UGA4 YDL210W GABA (gamma-aminobutyrate) permease genetic 1 1 1 Negative Genetic
YDR061W YDR061W Protein with similarity to ABC transporter family members genetic 1 1 1 Negative Genetic
TFB5 YDR079C-A Component of RNA polymerase II general transcription factor TFIIH genetic 1 1 1 Negative Genetic
SIP2 YGL208W One of three alternate beta subunits of the Snf1 kinase complex genetic 1 1 1 Negative Genetic
YIL055C YIL055C Putative protein of unknown function genetic 1 1 1 Negative Genetic
YKL183C-A YKL183C-A Putative protein of unknown function genetic 1 1 1 Negative Genetic
RSM19 YNR037C Mitochondrial ribosomal protein of the small subunit genetic 1 1 1 Negative Genetic
YOR186W YOR186W Putative protein of unknown function genetic 1 1 1 Negative Genetic
RQC2 YPL009C Component of the Ribosome Quality Control (RQC) complex genetic 1 1 1 Negative Genetic
YPL034W YPL034W Putative protein of unknown function genetic 1 1 1 Negative Genetic
YPL113C YPL113C Glyoxylate reductase genetic 1 1 1 Negative Genetic
TGS1 YPL157W Trimethyl guanosine synthase, conserved nucleolar methyl transferase genetic 1 1 1 Negative Genetic
UFD4 YKL010C Ubiquitin-protein ligase (E3) genetic 1 1 1 Negative Genetic
SRS2 YJL092W DNA helicase and DNA-dependent ATPase genetic 1 1 1 Negative Genetic
SLK19 YOR195W Kinetochore-associated protein genetic 1 1 1 Negative Genetic
TUB4 YLR212C Gamma-tubulin genetic 1 1 1 Synthetic Rescue
SGS1 YMR190C RecQ family nucleolar DNA helicase genetic 1 1 1 Positive Genetic
NIP1 YMR309C eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
ACT1 YFL039C Actin, structural protein in cytoskeleton physical 1 1 1 Affinity Capture-MS
KAP95 YLR347C Karyopherin beta genetic 1 1 1 Negative Genetic
RLI1 YDR091C Essential Fe-S protein physical 1 1 1 Affinity Capture-MS
PRE10 YOR362C Alpha 7 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
ALA1 YOR335C Cytoplasmic and mitochondrial alanyl-tRNA synthetase genetic 1 1 1 Negative Genetic
CCR4 YAL021C Component of the CCR4-NOT transcriptional complex genetic 1 1 1 Synthetic Rescue
KAP104 YBR017C Transportin or cytosolic karyopherin beta 2 physical 1 1 1 Affinity Capture-MS
NAB2 YGL122C Nuclear polyadenylated RNA-binding protein physical 1 1 1 Affinity Capture-RNA
PUF6 YDR496C Pumilio-homology domain protein genetic 1 1 1 Negative Genetic
BMS1 YPL217C GTPase required for ribosomal subunit synthesis and rRNA processing genetic 1 1 1 Positive Genetic
OLA1 YBR025C P-loop ATPase with similarity to human OLA1 and bacterial YchF physical 1 1 1 Affinity Capture-MS
EFT2 YDR385W Elongation factor 2 (EF-2), also encoded by EFT1 physical 1 1 1 Affinity Capture-MS
ADE4 YMR300C Phosphoribosylpyrophosphate amidotransferase (PRPPAT) physical 1 1 1 Affinity Capture-MS
ARC35 YNR035C Subunit of the ARP2/3 complex physical 1 1 1 Affinity Capture-MS
ARC35 YNR035C Subunit of the ARP2/3 complex genetic 1 1 1 Negative Genetic
ARD1 YHR013C Subunit of protein N-terminal acetyltransferase NatA genetic 1 1 1 Synthetic Rescue
ARO1 YDR127W Pentafunctional arom protein physical 1 1 1 Affinity Capture-MS
ARO1 YDR127W Pentafunctional arom protein genetic 1 1 1 Positive Genetic
ARP2 YDL029W Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
ARP3 YJR065C Essential component of the Arp2/3 complex physical 1 1 1 Affinity Capture-MS
ARP3 YJR065C Essential component of the Arp2/3 complex genetic 1 1 1 Negative Genetic
BMH2 YDR099W 14-3-3 protein, minor isoform physical 1 1 1 Affinity Capture-MS
BEM2 YER155C Rho GTPase activating protein (RhoGAP) genetic 1 1 1 Negative Genetic
CCA1 YER168C ATP (CTP):tRNA-specific tRNA nucleotidyltransferase genetic 1 1 1 Negative Genetic
CAF130 YGR134W Subunit of the CCR4-NOT transcriptional regulatory complex genetic 1 1 1 Synthetic Lethality
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit physical 1 1 1 Biochemical Activity
CDC28 YBR160W Cyclin-dependent kinase (CDK) catalytic subunit genetic 1 1 1 Synthetic Growth Defect
CDC12 YHR107C Component of the septin ring that is required for cytokinesis genetic 1 1 1 Negative Genetic
BNI1 YNL271C Formin genetic 1 1 1 Synthetic Growth Defect
CDC55 YGL190C Regulatory subunit B of protein phosphatase 2A (PP2A) genetic 1 1 1 Positive Genetic
HDA1 YNL021W Catalytic subunit of class II HDA1 histone deacetylase complex genetic 1 1 1 Negative Genetic
CHC1 YGL206C Clathrin heavy chain physical 1 1 1 Affinity Capture-MS
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex physical 1 1 1 Affinity Capture-MS
COP1 YDL145C Alpha subunit of COPI vesicle coatomer complex genetic 1 1 1 Positive Genetic
CPR1 YDR155C Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin) physical 1 1 1 Affinity Capture-MS
CYS4 YGR155W Cystathionine beta-synthase physical 1 1 1 Affinity Capture-MS
DCP2 YNL118C Catalytic subunit of Dcp1p-Dcp2p decapping enzyme complex genetic 1 1 1 Negative Genetic
CDC16 YKL022C Subunit of the anaphase-promoting complex/cyclosome (APC/C) genetic 1 1 1 Negative Genetic
ERG13 YML126C 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase physical 1 1 1 Affinity Capture-MS
FIP1 YJR093C Subunit of cleavage polyadenylation factor (CPF) genetic 1 1 1 Negative Genetic
FPR1 YNL135C Peptidyl-prolyl cis-trans isomerase (PPIase) physical 1 1 1 Affinity Capture-MS
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
FRS1 YLR060W Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase genetic 1 1 1 Positive Genetic
FKS1 YLR342W Catalytic subunit of 1,3-beta-D-glucan synthase physical 1 1 1 Affinity Capture-MS
GCN2 YDR283C Protein kinase genetic 1 1 1 Negative Genetic
GCN1 YGL195W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
CCT4 YDL143W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
GLO3 YER122C ADP-ribosylation factor GTPase activating protein (ARF GAP) physical 1 1 1 Affinity Capture-MS
GLY1 YEL046C Threonine aldolase physical 1 1 1 Affinity Capture-MS
HHF1 YBR009C Histone H4 physical 1 1 1 Affinity Capture-MS
IPP1 YBR011C Cytoplasmic inorganic pyrophosphatase (PPase) physical 1 1 1 Affinity Capture-MS
CLU1 YMR012W Subunit of the eukaryotic translation initiation factor 3 (eIF3) physical 1 1 1 Affinity Capture-MS
ARB1 YER036C ATPase of the ATP-binding cassette (ABC) family physical 1 1 1 Affinity Capture-MS
KRS1 YDR037W Lysyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
END3 YNL084C EH domain-containing protein involved in endocytosis genetic 1 1 1 Synthetic Growth Defect
LCB1 YMR296C Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LCB2 YDR062W Component of serine palmitoyltransferase genetic 1 1 1 Negative Genetic
LSM7 YNL147W Lsm (Like Sm) protein genetic 1 1 1 Positive Genetic
ENO2 YHR174W Enolase II, a phosphopyruvate hydratase physical 1 1 1 Affinity Capture-MS
MAK5 YBR142W Essential nucleolar protein genetic 1 1 1 Positive Genetic
MCD1 YDL003W Essential alpha-kleisin subunit of the cohesin complex genetic 1 1 1 Negative Genetic
GLT1 YDL171C NAD(+)-dependent glutamate synthase (GOGAT) physical 1 1 1 Affinity Capture-MS
CSE2 YNR010W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Synthetic Rescue
MED1 YPR070W Subunit of the RNA polymerase II mediator complex genetic 1 1 1 Positive Genetic
COG3 YER157W Essential component of the conserved oligomeric Golgi complex genetic 1 1 1 Positive Genetic
ADA2 YDR448W Transcription coactivator genetic 1 1 1 Synthetic Rescue
FBA1 YKL060C Fructose 1,6-bisphosphate aldolase physical 1 1 1 Affinity Capture-MS
MOT1 YPL082C Essential protein involved in regulation of transcription genetic 1 1 1 Negative Genetic
MRP20 YDR405W Mitochondrial ribosomal protein of the large subunit genetic 1 1 1 Positive Genetic
MEC1 YBR136W Genome integrity checkpoint protein and PI kinase superfamily member genetic 1 1 1 Negative Genetic
MYO2 YOR326W Type V myosin motor involved in actin-based transport of cargos genetic 1 1 1 Positive Genetic
HTZ1 YOL012C Histone variant H2AZ genetic 1 1 1 Synthetic Rescue
ARP8 YOR141C Nuclear actin-related protein involved in chromatin remodeling genetic 1 1 1 Negative Genetic
FAS2 YPL231W Alpha subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
AHA1 YDR214W Co-chaperone that binds Hsp82p and activates its ATPase activity physical 1 1 1 Affinity Capture-MS
HMO1 YDR174W Chromatin associated high mobility group (HMG) family member genetic 1 1 1 Synthetic Growth Defect
DOA4 YDR069C Ubiquitin hydrolase genetic 1 1 1 Negative Genetic
DUR12 YBR208C Urea amidolyase physical 1 1 1 Affinity Capture-MS
PDA1 YER178W E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex physical 1 1 1 Affinity Capture-MS
PEP3 YLR148W Component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
PFK1 YGR240C Alpha subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
POL1 YNL102W Catalytic subunit of the DNA polymerase I alpha-primase complex genetic 1 1 1 Negative Genetic
POL12 YBL035C B subunit of DNA polymerase alpha-primase complex genetic 1 1 1 Negative Genetic
POP7 YBR167C Subunit of RNase MRP, nuclear RNase P and telomerase genetic 1 1 1 Negative Genetic
HSP82 YPL240C Hsp90 chaperone genetic 1 1 1 Synthetic Growth Defect
POL2 YNL262W Catalytic subunit of DNA polymerase (II) epsilon genetic 1 1 1 Negative Genetic
MVD1 YNR043W Mevalonate pyrophosphate decarboxylase physical 1 1 1 Affinity Capture-MS
MIR1 YJR077C Mitochondrial phosphate carrier physical 1 1 1 Affinity Capture-MS
GCN20 YFR009W Positive regulator of the Gcn2p kinase activity physical 1 1 1 Affinity Capture-MS
RAD3 YER171W 5' to 3' DNA helicase physical 1 1 1 Affinity Capture-MS
CPA2 YJR109C Large subunit of carbamoyl phosphate synthetase physical 1 1 1 Affinity Capture-MS
RET2 YFR051C Delta subunit of the coatomer complex (COPI) genetic 1 1 1 Negative Genetic
RFC2 YJR068W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFC5 YBR087W Subunit of heteropentameric Replication factor C (RF-C) genetic 1 1 1 Negative Genetic
RFA3 YJL173C Subunit of heterotrimeric Replication Protein A (RPA) genetic 1 1 1 Negative Genetic
IWR1 YDL115C RNA polymerase II transport factor, conserved from yeast to humans genetic 1 1 1 Positive Genetic
RPB10 YOR210W RNA polymerase subunit ABC10-beta genetic 1 1 1 Negative Genetic
ADE3 YGR204W Cytoplasmic trifunctional enzyme physical 1 1 1 Affinity Capture-MS
DBP2 YNL112W ATP-dependent RNA helicase of the DEAD-box protein family physical 1 1 1 Affinity Capture-MS
PUP3 YER094C Beta 3 subunit of the 20S proteasome genetic 1 1 1 Negative Genetic
CDC6 YJL194W Essential ATP-binding protein required for DNA replication genetic 1 1 1 Negative Genetic
PGI1 YBR196C Glycolytic enzyme phosphoglucose isomerase physical 1 1 1 Affinity Capture-MS
CSE1 YGL238W Nuclear envelope protein that acts as a recycling factor genetic 1 1 1 Negative Genetic
CCT8 YJL008C Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
PFK2 YMR205C Beta subunit of heterooctameric phosphofructokinase physical 1 1 1 Affinity Capture-MS
BUR2 YLR226W Cyclin for the Sgv1p (Bur1p) protein kinase genetic 1 1 1 Synthetic Lethality
ROM2 YLR371W Guanine nucleotide exchange factor (GEF) for Rho1p and Rho2p genetic 1 1 1 Positive Genetic
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CCT6 YDR188W Subunit of the cytosolic chaperonin Cct ring complex genetic 1 1 1 Positive Genetic
CCT7 YJL111W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
CAM1 YPL048W One of two isoforms of the gamma subunit of eEF1B physical 1 1 1 Affinity Capture-MS
NEW1 YPL226W Translation termination and ribosome biogenesis factor physical 1 1 1 Affinity Capture-MS
GLN1 YPR035W Glutamine synthetase (GS) physical 1 1 1 Affinity Capture-MS
BRO1 YPL084W Cytoplasmic class E vacuolar protein sorting (VPS) factor genetic 1 1 1 Negative Genetic
PEP5 YMR231W Histone E3 ligase, component of CORVET membrane tethering complex genetic 1 1 1 Synthetic Growth Defect
DIM1 YPL266W Essential 18S rRNA dimethylase (dimethyladenosine transferase) genetic 1 1 1 Positive Genetic
GET3 YDL100C Guanine nucleotide exchange factor for Gpa1p physical 1 1 1 Affinity Capture-MS
BNA3 YJL060W Kynurenine aminotransferase physical 1 1 1 Affinity Capture-MS
CDC13 YDL220C Single stranded DNA-binding protein found at TG1-3 telomere G-tails genetic 1 1 1 Negative Genetic
EGD2 YHR193C Alpha subunit of the nascent polypeptide-associated complex (NAC) physical 1 1 1 Affinity Capture-MS
ABP1 YCR088W Actin-binding protein of the cortical actin cytoskeleton physical 1 1 1 Affinity Capture-MS
CAR2 YLR438W L-ornithine transaminase (OTAse) physical 1 1 1 Affinity Capture-MS
GND1 YHR183W 6-phosphogluconate dehydrogenase (decarboxylating) physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A physical 1 1 1 Affinity Capture-MS
HYP2 YEL034W Translation elongation factor eIF-5A genetic 1 1 1 Negative Genetic
ADO1 YJR105W Adenosine kinase physical 1 1 1 Affinity Capture-MS
ADO1 YJR105W Adenosine kinase genetic 1 1 1 Positive Genetic
RNR2 YJL026W Ribonucleotide-diphosphate reductase (RNR), small subunit physical 1 1 1 Affinity Capture-MS
GPP1 YIL053W Constitutively expressed DL-glycerol-3-phosphate phosphatase physical 1 1 1 Affinity Capture-MS
ARF1 YDL192W ADP-ribosylation factor physical 1 1 1 Affinity Capture-MS
MGE1 YOR232W Mitochondrial matrix cochaperone genetic 1 1 1 Negative Genetic
AHP1 YLR109W Thiol-specific peroxiredoxin physical 1 1 1 Affinity Capture-MS
GSP2 YOR185C GTP binding protein (mammalian Ranp homolog) physical 1 1 1 Affinity Capture-MS
GSP2 YOR185C GTP binding protein (mammalian Ranp homolog) genetic 1 1 1 Negative Genetic
DPS1 YLL018C Aspartyl-tRNA synthetase, primarily cytoplasmic physical 1 1 1 Affinity Capture-MS
CDC53 YDL132W Cullin physical 1 1 1 Affinity Capture-Western
CDC53 YDL132W Cullin genetic 1 1 1 Negative Genetic
FET3 YMR058W Ferro-O2-oxidoreductase genetic 1 1 1 Synthetic Growth Defect
FAA4 YMR246W Long chain fatty acyl-CoA synthetase physical 1 1 1 Affinity Capture-MS
OYE2 YHR179W Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN) physical 1 1 1 Affinity Capture-MS
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) physical 1 1 1 Affinity Capture-MS
POR1 YNL055C Mitochondrial porin (voltage-dependent anion channel) genetic 1 1 1 Negative Genetic
FDO1 YMR144W Protein involved in directionality of mating type switching genetic 1 1 1 Negative Genetic
PMA1 YGL008C Plasma membrane P2-type H+-ATPase physical 1 1 1 Affinity Capture-MS
PMA1 YGL008C Plasma membrane P2-type H+-ATPase genetic 1 1 1 Negative Genetic
BUD13 YGL174W Subunit of the RES complex genetic 1 1 1 Negative Genetic
AAT2 YLR027C Cytosolic aspartate aminotransferase involved in nitrogen metabolism physical 1 1 1 Affinity Capture-MS
ADK1 YDR226W Adenylate kinase, required for purine metabolism physical 1 1 1 Affinity Capture-MS
COF1 YLL050C Cofilin, involved in pH-dependent actin filament depolarization physical 1 1 1 Affinity Capture-MS
GPD1 YDL022W NAD-dependent glycerol-3-phosphate dehydrogenase physical 1 1 1 Affinity Capture-MS
FAR1 YJL157C CDK inhibitor and nuclear anchor genetic 1 1 1 Negative Genetic
PRS3 YHL011C 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase genetic 1 1 1 Synthetic Rescue
ATG12 YBR217W Ubiquitin-like modifier involved in autophagy and the Cvt pathway physical 1 1 1 Affinity Capture-MS
HSP104 YLL026W Disaggregase physical 1 1 1 Affinity Capture-MS
HEF3 YNL014W Translational elongation factor EF-3 physical 1 1 1 Affinity Capture-MS
PET9 YBL030C Major ADP/ATP carrier of the mitochondrial inner membrane physical 1 1 1 Affinity Capture-MS
MAE1 YKL029C Mitochondrial malic enzyme physical 1 1 1 Affinity Capture-MS
PBR1 YNL181W Putative oxidoreductase genetic 1 1 1 Positive Genetic
APT1 YML022W Adenine phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
ERG10 YPL028W Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase) physical 1 1 1 Affinity Capture-MS
FUM1 YPL262W Fumarase physical 1 1 1 Affinity Capture-MS
MRS6 YOR370C Rab escort protein genetic 1 1 1 Negative Genetic
CCT3 YJL014W Subunit of the cytosolic chaperonin Cct ring complex physical 1 1 1 Affinity Capture-MS
HEM15 YOR176W Ferrochelatase physical 1 1 1 Affinity Capture-MS
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p physical 1 1 1 Affinity Capture-MS
PSH1 YOL054W E3 ubiquitin ligase targeting centromere-binding protein Cse4p genetic 1 1 1 Negative Genetic
GPP2 YER062C DL-glycerol-3-phosphate phosphatase involved in glycerol biosynthesis physical 1 1 1 Affinity Capture-MS
ADH3 YMR083W Mitochondrial alcohol dehydrogenase isozyme III physical 1 1 1 Affinity Capture-MS
CDC60 YPL160W Cytosolic leucyl tRNA synthetase physical 1 1 1 Affinity Capture-MS
CDC60 YPL160W Cytosolic leucyl tRNA synthetase genetic 1 1 1 Negative Genetic
GRS1 YBR121C Cytoplasmic and mitochondrial glycyl-tRNA synthase physical 1 1 1 Affinity Capture-MS
PDC5 YLR134W Minor isoform of pyruvate decarboxylase physical 1 1 1 Affinity Capture-MS
ERG20 YJL167W Farnesyl pyrophosphate synthetase physical 1 1 1 Affinity Capture-MS
POL30 YBR088C Proliferating cell nuclear antigen (PCNA) genetic 1 1 1 Negative Genetic
RNA1 YMR235C GTPase activating protein (GAP) for Gsp1p physical 1 1 1 Affinity Capture-MS
EST1 YLR233C TLC1 RNA-associated factor involved in telomere length regulation genetic 1 1 1 Synthetic Growth Defect
HOM6 YJR139C Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase) physical 1 1 1 Affinity Capture-MS
HUL5 YGL141W Multiubiquitin chain assembly factor (E4) physical 1 1 1 Reconstituted Complex
ERG6 YML008C Delta(24)-sterol C-methyltransferase physical 1 1 1 Affinity Capture-MS
MET6 YER091C Cobalamin-independent methionine synthase physical 1 1 1 Affinity Capture-MS
NTF2 YER009W Nuclear envelope protein genetic 1 1 1 Negative Genetic
FRS2 YFL022C Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase physical 1 1 1 Affinity Capture-MS
DNL4 YOR005C DNA ligase required for nonhomologous end-joining (NHEJ) genetic 1 1 1 Synthetic Rescue
HIR1 YBL008W Subunit of the HIR complex genetic 1 1 1 Negative Genetic
HOG1 YLR113W Mitogen-activated protein kinase involved in osmoregulation physical 1 1 1 Affinity Capture-MS
ADE17 YMR120C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Affinity Capture-MS
HHT1 YBR010W Histone H3 genetic 1 1 1 Negative Genetic
KSS1 YGR040W Mitogen-activated protein kinase (MAPK) physical 1 1 1 Affinity Capture-MS
HOM3 YER052C Aspartate kinase (L-aspartate 4-P-transferase) physical 1 1 1 Affinity Capture-MS
PGM1 YKL127W Phosphoglucomutase, minor isoform physical 1 1 1 Affinity Capture-MS
FPK1 YNR047W Ser/Thr protein kinase genetic 1 1 1 Positive Genetic
ARF2 YDL137W ADP-ribosylation factor physical 1 1 1 Affinity Capture-MS
PCL6 YER059W Pho85p cyclin of the Pho80p subfamily genetic 1 1 1 Negative Genetic
APA1 YCL050C AP4A phosphorylase physical 1 1 1 Affinity Capture-MS
EAP1 YKL204W eIF4E-associated protein, competes with eIF4G for binding to eIF4E genetic 1 1 1 Synthetic Rescue
CPA1 YOR303W Small subunit of carbamoyl phosphate synthetase physical 1 1 1 Affinity Capture-MS
DBF2 YGR092W Ser/Thr kinase involved in transcription and stress response genetic 1 1 1 Negative Genetic
PPZ1 YML016C Serine/threonine protein phosphatase Z, isoform of Ppz2p genetic 1 1 1 Positive Genetic
IST3 YIR005W Component of the U2 snRNP genetic 1 1 1 Synthetic Rescue
ARG1 YOL058W Arginosuccinate synthetase physical 1 1 1 Affinity Capture-MS
GCR2 YNL199C Transcriptional activator of genes involved in glycolysis genetic 1 1 1 Synthetic Growth Defect
ADE6 YGR061C Formylglycinamidine-ribonucleotide (FGAM)-synthetase physical 1 1 1 Affinity Capture-MS
HOM2 YDR158W Aspartic beta semi-aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
BIR1 YJR089W Subunit of chromosomal passenger complex (CPC) genetic 1 1 1 Positive Genetic
FMP48 YGR052W Putative protein of unknown function physical 1 1 1 Reconstituted Complex
ESS1 YJR017C Peptidylprolyl-cis/trans-isomerase (PPIase) genetic 1 1 1 Positive Genetic
MLP2 YIL149C Myosin-like protein associated with the nuclear envelope physical 1 1 1 Affinity Capture-MS
NBP2 YDR162C Protein involved in the HOG (high osmolarity glycerol) pathway genetic 1 1 1 Positive Genetic
CTK3 YML112W Gamma subunit of C-terminal domain kinase I genetic 1 1 1 Synthetic Growth Defect
IME2 YJL106W Serine/threonine protein kinase involved in activation of meiosis genetic 1 1 1 Negative Genetic
DAD1 YDR016C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DAD2 YKR083C Essential subunit of the Dam1 complex (aka DASH complex) genetic 1 1 1 Negative Genetic
DDI1 YER143W Aspartic-type endopeptidase physical 1 1 1 Affinity Capture-Western
CDC43 YGL155W Beta subunit of geranylgeranyltransferase type I genetic 1 1 1 Negative Genetic
ARG3 YJL088W Ornithine carbamoyltransferase physical 1 1 1 Affinity Capture-MS
GDH1 YOR375C NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
BNI4 YNL233W Targeting subunit for Glc7p protein phosphatase genetic 1 1 1 Negative Genetic
HCS1 YKL017C Hexameric DNA polymerase alpha-associated DNA helicase A genetic 1 1 1 Positive Genetic
LST7 YGR057C Subunit of the Lst4p-Lst7p GTPase activating protein complex for Gtr2p genetic 1 1 1 Synthetic Rescue
MOB2 YFL034C-B Activator of Cbk1p kinase genetic 1 1 1 Negative Genetic
MAD2 YJL030W Component of the spindle-assembly checkpoint complex genetic 1 1 1 Negative Genetic
NDC80 YIL144W Component of the kinetochore-associated Ndc80 complex genetic 1 1 1 Negative Genetic
MMR1 YLR190W Phosphorylated protein of the mitochondrial outer membrane genetic 1 1 1 Negative Genetic
RIM101 YHL027W Cys2His2 zinc-finger transcriptional repressor genetic 1 1 1 Negative Genetic
CDC34 YDR054C Ubiquitin-conjugating enzyme (E2) genetic 1 1 1 Synthetic Lethality
BAS1 YKR099W Myb-related transcription factor genetic 1 1 1 Negative Genetic
RNH202 YDR279W Ribonuclease H2 subunit genetic 1 1 1 Negative Genetic
NST1 YNL091W Translational inhibitor and suppressor of proteasome-assembly defects genetic 1 1 1 Negative Genetic
APC11 YDL008W Catalytic core subunit, Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
APC4 YDR118W Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Positive Genetic
APC9 YLR102C Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C) genetic 1 1 1 Negative Genetic
RPL4A YBR031W Ribosomal 60S subunit protein L4A physical 1 1 1 Affinity Capture-MS
DOC1 YGL240W Processivity factor genetic 1 1 1 Negative Genetic
CHL1 YPL008W Probable DNA helicase genetic 1 1 1 Negative Genetic
BRF1 YGR246C TFIIIB B-related factor physical 1 1 1 Affinity Capture-MS
BRE5 YNR051C Ubiquitin protease cofactor genetic 1 1 1 Synthetic Growth Defect
RPL22A YLR061W Ribosomal 60S subunit protein L22A physical 1 1 1 Affinity Capture-MS
CSE4 YKL049C Centromeric histone H3-like protein genetic 1 1 1 Negative Genetic
ATG8 YBL078C Ub-like protein genetic 1 1 1 Phenotypic Enhancement
BUB1 YGR188C Protein kinase involved in the cell cycle checkpoint into anaphase genetic 1 1 1 Synthetic Rescue
MOT2 YER068W Ubiquitin-protein ligase subunit of the CCR4-NOT complex genetic 1 1 1 Synthetic Growth Defect
CLB5 YPR120C B-type cyclin involved in DNA replication during S phase genetic 1 1 1 Synthetic Rescue
DBP5 YOR046C Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family physical 1 1 1 Affinity Capture-MS
ELO3 YLR372W Elongase physical 1 1 1 Affinity Capture-MS
HXK2 YGL253W Hexokinase isoenzyme 2 physical 1 1 1 Affinity Capture-MS
MPS1 YDL028C Dual-specificity kinase genetic 1 1 1 Positive Genetic
PUP1 YOR157C Beta 2 subunit of the 20S proteasome physical 1 1 1 Affinity Capture-Western
PEP7 YDR323C Adaptor protein involved in vesicle-mediated vacuolar protein sorting genetic 1 1 1 Synthetic Lethality
KAR2 YJL034W ATPase involved in protein import into the ER genetic 1 1 1 Positive Genetic
MBF1 YOR298C-A Transcriptional coactivator physical 1 1 1 Affinity Capture-MS
GAP1 YKR039W General amino acid permease physical 1 1 1 Affinity Capture-MS
CSG2 YBR036C Endoplasmic reticulum membrane protein genetic 1 1 1 Positive Genetic
POL3 YDL102W Catalytic subunit of DNA polymerase delta genetic 1 1 1 Negative Genetic
POL31 YJR006W Subunit of DNA polymerase delta (polymerase III) genetic 1 1 1 Positive Genetic
MCM7 YBR202W Component of the Mcm2-7 hexameric helicase complex genetic 1 1 1 Negative Genetic
ESC1 YMR219W Protein involved in telomeric silencing physical 1 1 1 Affinity Capture-MS
CUS2 YNL286W Putative checkpoint factor in transcription genetic 1 1 1 Negative Genetic
NNK1 YKL171W Protein kinase genetic 1 1 1 Negative Genetic
MRI1 YPR118W 5'-methylthioribose-1-phosphate isomerase physical 1 1 1 Affinity Capture-MS
RPL1B YGL135W Ribosomal 60S subunit protein L1B physical 1 1 1 Affinity Capture-MS
ATP1 YBL099W Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase physical 1 1 1 Affinity Capture-MS
PFY1 YOR122C Profilin genetic 1 1 1 Positive Genetic
RPL31A YDL075W Ribosomal 60S subunit protein L31A physical 1 1 1 Affinity Capture-MS
HO YDL227C Site-specific endonuclease physical 1 1 1 Affinity Capture-Western
HOC1 YJR075W Alpha-1,6-mannosyltransferase genetic 1 1 1 Synthetic Growth Defect
PMT1 YDL095W Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
PMT2 YAL023C Protein O-mannosyltransferase of the ER membrane physical 1 1 1 Affinity Capture-MS
NUP188 YML103C Subunit of the inner ring of the nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
ASN1 YPR145W Asparagine synthetase physical 1 1 1 Affinity Capture-MS
RPL11B YGR085C Ribosomal 60S subunit protein L11B physical 1 1 1 Affinity Capture-MS
ARL3 YPL051W ARF-like small GTPase of the RAS superfamily genetic 1 1 1 Negative Genetic
ENT1 YDL161W Epsin-like protein involved in endocytosis and actin patch assembly genetic 1 1 1 Negative Genetic
RNR4 YGR180C Ribonucleotide-diphosphate reductase (RNR) small subunit physical 1 1 1 Affinity Capture-MS
PDR1 YGL013C Transcription factor that regulates the pleiotropic drug response genetic 1 1 1 Phenotypic Enhancement
EAF7 YNL136W Subunit of the NuA4 histone acetyltransferase complex genetic 1 1 1 Synthetic Rescue
EFT1 YOR133W Elongation factor 2 (EF-2), also encoded by EFT2 physical 1 1 1 Affinity Capture-MS
GDH3 YAL062W NADP(+)-dependent glutamate dehydrogenase physical 1 1 1 Affinity Capture-MS
RPL14B YHL001W Ribosomal 60S subunit protein L14B physical 1 1 1 Affinity Capture-MS
RPL15A YLR029C Ribosomal 60S subunit protein L15A genetic 1 1 1 Negative Genetic
RPL27B YDR471W Ribosomal 60S subunit protein L27B physical 1 1 1 Affinity Capture-MS
LYS21 YDL131W Homocitrate synthase isozyme physical 1 1 1 Affinity Capture-MS
ASN2 YGR124W Asparagine synthetase physical 1 1 1 Affinity Capture-MS
AIM44 YPL158C Regulator of Cdc42p and Rho1p genetic 1 1 1 Positive Genetic
ARO8 YGL202W Aromatic aminotransferase I physical 1 1 1 Affinity Capture-MS
HBS1 YKR084C GTPase with similarity to translation release factors genetic 1 1 1 Synthetic Growth Defect
FUR1 YHR128W Uracil phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
RPL16B YNL069C Ribosomal 60S subunit protein L16B physical 1 1 1 Affinity Capture-MS
ARR3 YPR201W Plasma membrane metalloid/H+ antiporter genetic 1 1 1 Negative Genetic
HEM14 YER014W Protoporphyrinogen oxidase genetic 1 1 1 Synthetic Growth Defect
ERG2 YMR202W C-8 sterol isomerase physical 1 1 1 Affinity Capture-MS
RPL40A YIL148W Ubiquitin-ribosomal 60S subunit protein L40A fusion protein genetic 1 1 1 Negative Genetic
MRH1 YDR033W Protein that localizes primarily to the plasma membrane physical 1 1 1 Affinity Capture-MS
MET17 YLR303W O-acetyl homoserine-O-acetyl serine sulfhydrylase physical 1 1 1 Affinity Capture-MS
GLK1 YCL040W Glucokinase physical 1 1 1 Affinity Capture-MS
PUS9 YDL036C Mitochondrial tRNA:pseudouridine synthase physical 1 1 1 Affinity Capture-MS
BPL1 YDL141W Biotin:apoprotein ligase physical 1 1 1 Affinity Capture-MS
NTH1 YDR001C Neutral trehalase, degrades trehalose physical 1 1 1 Affinity Capture-MS
ARG56 YER069W Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase physical 1 1 1 Affinity Capture-MS
ADE16 YLR028C Enzyme of 'de novo' purine biosynthesis physical 1 1 1 Affinity Capture-MS
MET10 YFR030W Subunit alpha of assimilatory sulfite reductase physical 1 1 1 Affinity Capture-MS
RIM8 YGL045W Protein involved in proteolytic activation of Rim101p genetic 1 1 1 Negative Genetic
GUT1 YHL032C Glycerol kinase genetic 1 1 1 Negative Genetic
GRE3 YHR104W Aldose reductase physical 1 1 1 Affinity Capture-MS
HIS6 YIL020C Enzyme that catalyzes the fourth step in the histidine pathway genetic 1 1 1 Synthetic Rescue
ALD6 YPL061W Cytosolic aldehyde dehydrogenase physical 1 1 1 Affinity Capture-MS
OLE1 YGL055W Delta(9) fatty acid desaturase physical 1 1 1 Affinity Capture-MS
RIA1 YNL163C Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis genetic 1 1 1 Negative Genetic
ADE12 YNL220W Adenylosuccinate synthase physical 1 1 1 Affinity Capture-MS
RIM21 YNL294C pH sensor molecule, component of the RIM101 pathway genetic 1 1 1 Negative Genetic
GLN4 YOR168W Glutamine tRNA synthetase physical 1 1 1 Affinity Capture-MS
FAS1 YKL182W Beta subunit of fatty acid synthetase physical 1 1 1 Affinity Capture-MS
PHO13 YDL236W Conserved phosphatase acting as a metabolite repair enzyme genetic 1 1 1 Positive Genetic
MUB1 YMR100W MYND domain-containing protein genetic 1 1 1 Positive Genetic
LAP3 YNL239W Cysteine aminopeptidase with homocysteine-thiolactonase activity physical 1 1 1 Affinity Capture-MS
RPL20A YMR242C Ribosomal 60S subunit protein L20A physical 1 1 1 Affinity Capture-MS
RPL4B YDR012W Ribosomal 60S subunit protein L4B physical 1 1 1 Affinity Capture-MS
RPL17B YJL177W Ribosomal 60S subunit protein L17B physical 1 1 1 Affinity Capture-MS
RPL35A YDL191W Ribosomal 60S subunit protein L35A physical 1 1 1 Affinity Capture-MS
RPL8A YHL033C Ribosomal 60S subunit protein L8A physical 1 1 1 Affinity Capture-MS
RPL33B YOR234C Ribosomal 60S subunit protein L33B physical 1 1 1 Affinity Capture-MS
RPL43A YPR043W Ribosomal 60S subunit protein L43A physical 1 1 1 Affinity Capture-MS
RPL6A YML073C Ribosomal 60S subunit protein L6A physical 1 1 1 Affinity Capture-MS
NUP192 YJL039C Essential subunit of inner ring of nuclear pore complex (NPC) genetic 1 1 1 Negative Genetic
GUA1 YMR217W GMP synthase physical 1 1 1 Affinity Capture-MS
LDB7 YBL006C Component of the RSC chromatin remodeling complex genetic 1 1 1 Synthetic Growth Defect
RPL26A YLR344W Ribosomal 60S subunit protein L26A physical 1 1 1 Affinity Capture-MS
RPL26B YGR034W Ribosomal 60S subunit protein L26B physical 1 1 1 Affinity Capture-MS
ARV1 YLR242C Cortical ER protein genetic 1 1 1 Positive Genetic
PCM1 YEL058W Essential N-acetylglucosamine-phosphate mutase physical 1 1 1 Affinity Capture-MS
PDX3 YBR035C Pyridoxine (pyridoxamine) phosphate oxidase genetic 1 1 1 Negative Genetic
NMT1 YLR195C N-myristoyl transferase physical 1 1 1 Affinity Capture-MS
PGA2 YNL149C Essential protein required for maturation of Gas1p and Pho8p genetic 1 1 1 Positive Genetic
PAN5 YHR063C 2-dehydropantoate 2-reductase physical 1 1 1 Affinity Capture-MS
CYC1 YJR048W Cytochrome c, isoform 1 physical 1 1 1 Affinity Capture-MS
PYP1 YNL010W Sugar alcohol phosphatase physical 1 1 1 Affinity Capture-MS
EOS1 YNL080C Protein involved in N-glycosylation genetic 1 1 1 Positive Genetic
CYT1 YOR065W Cytochrome c1 physical 1 1 1 Affinity Capture-MS
RPL14A YKL006W Ribosomal 60S subunit protein L14A physical 1 1 1 Affinity Capture-MS
ALO1 YML086C D-Arabinono-1,4-lactone oxidase physical 1 1 1 Affinity Capture-MS
PNC1 YGL037C Nicotinamidase that converts nicotinamide to nicotinic acid physical 1 1 1 Affinity Capture-MS
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins physical 1 1 1 Affinity Capture-MS
RHO3 YIL118W Non-essential small GTPase of the Rho/Rac family of Ras-like proteins genetic 1 1 1 Negative Genetic
PDR3 YBL005W Transcriptional activator of the pleiotropic drug resistance network genetic 1 1 1 Phenotypic Enhancement
RPL22B YFL034C-A Ribosomal 60S subunit protein L22A physical 1 1 1 Affinity Capture-MS
RPL31B YLR406C Ribosomal 60S subunit protein L31B physical 1 1 1 Affinity Capture-MS
HXT3 YDR345C Low affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Affinity Capture-MS
HXT1 YHR094C Low-affinity glucose transporter of the major facilitator superfamily physical 1 1 1 Affinity Capture-MS
MDM32 YOR147W Mitochondrial inner membrane protein with similarity to Mdm31p genetic 1 1 1 Negative Genetic
KRE9 YJL174W Glycoprotein involved in cell wall beta-glucan assembly genetic 1 1 1 Positive Genetic
OAC1 YKL120W Mitochondrial inner membrane transporter physical 1 1 1 Affinity Capture-MS
ERG3 YLR056W C-5 sterol desaturase genetic 1 1 1 Synthetic Rescue
KRE1 YNL322C Cell wall glycoprotein involved in beta-glucan assembly genetic 1 1 1 Positive Genetic
CDS1 YBR029C Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase) genetic 1 1 1 Negative Genetic
CDC8 YJR057W Nucleoside monophosphate and nucleoside diphosphate kinase genetic 1 1 1 Negative Genetic
DAK1 YML070W Dihydroxyacetone kinase physical 1 1 1 Affinity Capture-MS
DFG10 YIL049W Probable polyprenol reductase genetic 1 1 1 Negative Genetic
PAI3 YMR174C Cytoplasmic proteinase A (Pep4p) inhibitor genetic 1 1 1 Negative Genetic
QRI1 YDL103C UDP-N-acetylglucosamine pyrophosphorylase genetic 1 1 1 Positive Genetic
MET5 YJR137C Sulfite reductase beta subunit physical 1 1 1 Affinity Capture-MS
HIS1 YER055C ATP phosphoribosyltransferase physical 1 1 1 Affinity Capture-MS
ERG9 YHR190W Farnesyl-diphosphate farnesyl transferase (squalene synthase) physical 1 1 1 Affinity Capture-MS
MYG1 YER156C Protein involved in mitochondrial function physical 1 1 1 Affinity Capture-MS
RPL12B YDR418W Ribosomal 60S subunit protein L12B physical 1 1 1 Affinity Capture-MS
MAM3 YOL060C Protein involved in magnesium homeostasis physical 1 1 1 Affinity Capture-MS
NCE103 YNL036W Carbonic anhydrase genetic 1 1 1 Negative Genetic
NAT4 YMR069W N alpha-acetyl-transferase genetic 1 1 1 Negative Genetic
MRK1 YDL079C Glycogen synthase kinase 3 (GSK-3) homolog genetic 1 1 1 Positive Genetic
GPI10 YGL142C Integral membrane protein involved in GPI anchor synthesis genetic 1 1 1 Positive Genetic
EFM4 YIL064W Lysine methyltransferase genetic 1 1 1 Negative Genetic
NHX1 YDR456W Na+/H+ and K+/H+ exchanger genetic 1 1 1 Synthetic Growth Defect
MMM1 YLL006W ER integral membrane protein, ERMES complex subunit genetic 1 1 1 Positive Genetic
FSH2 YMR222C Putative serine hydrolase that localizes to the cytoplasm genetic 1 1 1 Negative Genetic
GPI11 YDR302W ER membrane protein involved in a late step of GPI anchor assembly genetic 1 1 1 Positive Genetic